locus-tag	class	description
C1A46_RS00025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1A46_RS00030	COG4172	Belongs to the ABC transporter superfamily
C1A46_RS00035	COG4239	(ABC) transporter, permease
C1A46_RS00040	COG4174	ABC transporter (Permease)
C1A46_RS00050	COG4166	transmembrane transport
C1A46_RS00080	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
C1A46_RS00095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1A46_RS00100	COG1960	acyl-CoA dehydrogenase activity
C1A46_RS00145	COG0539	negative regulation of cytoplasmic translation
C1A46_RS00150	COG2855	membrane
C1A46_RS00155	COG0583	DNA-binding transcription factor activity
C1A46_RS00165	COG2951	lytic endotransglycosylase activity
C1A46_RS00180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C1A46_RS00195	COG2816	NAD+ diphosphatase activity
C1A46_RS00200	COG1605	Chorismate mutase
C1A46_RS00200	COG0077	Prephenate dehydratase
C1A46_RS00210	COG3474	cytochrome
C1A46_RS00220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C1A46_RS00230	COG1845	cytochrome c oxidase, subunit III
C1A46_RS00235	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C1A46_RS00260	COG1376	ErfK ybiS ycfS ynhG family protein
C1A46_RS00290	COG0346	lactoylglutathione lyase activity
C1A46_RS00295	COG0489	protein tyrosine kinase activity
C1A46_RS00300	COG0033	Phosphoglucomutase
C1A46_RS00315	COG1073	alpha beta
C1A46_RS00350	COG1272	protein, Hemolysin III
C1A46_RS00415	COG3339	Conserved Protein
C1A46_RS00430	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
C1A46_RS00445	COG4181	ATPase activity
C1A46_RS00455	COG0670	Belongs to the BI1 family
C1A46_RS00480	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
C1A46_RS00495	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1A46_RS00500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
C1A46_RS00510	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1A46_RS00555	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
C1A46_RS00565	COG4208	sulfate ABC transporter
C1A46_RS00570	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
C1A46_RS00575	COG3459	Glycosyltransferase 36 associated
C1A46_RS00585	COG0384	phenazine biosynthesis protein PhzF
C1A46_RS00590	COG2226	methyltransferase
C1A46_RS00600	COG1028	Short-chain dehydrogenase reductase Sdr
C1A46_RS00605	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1A46_RS00620	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1A46_RS00625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
C1A46_RS00635	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1A46_RS00635	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C1A46_RS00650	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
C1A46_RS00660	COG2153	protein acetylation
C1A46_RS00675	COG1643	Atp-dependent helicase
C1A46_RS00680	COG1643	Atp-dependent helicase
C1A46_RS00705	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
C1A46_RS00715	COG1388	LysM domain
C1A46_RS00715	COG1376	ErfK ybiS ycfS ynhG family protein
C1A46_RS00720	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
C1A46_RS00730	COG0180	Tryptophanyl-tRNA synthetase
C1A46_RS00735	COG0728	peptidoglycan biosynthetic process
C1A46_RS00745	COG0281	malic enzyme
C1A46_RS00745	COG0280	phosphate acetyltransferase
C1A46_RS00770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1A46_RS00775	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C1A46_RS00775	COG0116	Belongs to the methyltransferase superfamily
C1A46_RS00790	COG0616	signal peptide processing
C1A46_RS00800	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
C1A46_RS00805	COG1137	ATPase activity
C1A46_RS00810	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
C1A46_RS00820	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
C1A46_RS00825	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1A46_RS00835	COG0071	Belongs to the small heat shock protein (HSP20) family
C1A46_RS00865	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1A46_RS00870	COG2860	membrane
C1A46_RS00875	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C1A46_RS00900	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
C1A46_RS00905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1A46_RS00910	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C1A46_RS00920	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C1A46_RS00920	COG1648	precorrin-2 dehydrogenase activity
C1A46_RS00930	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
C1A46_RS00935	COG0175	sulfate reduction
C1A46_RS00950	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1A46_RS00975	COG2197	response regulator
C1A46_RS00980	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1A46_RS01000	COG1218	3'(2'),5'-bisphosphate nucleotidase
C1A46_RS01015	COG2197	response regulator
C1A46_RS01070	COG1012	belongs to the aldehyde dehydrogenase family
C1A46_RS01075	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1A46_RS01080	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
C1A46_RS01085	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
C1A46_RS01110	COG0351	phosphomethylpyrimidine kinase
C1A46_RS01115	COG5001	Diguanylate cyclase
C1A46_RS01130	COG1174	glycine betaine transport
C1A46_RS01135	COG1125	glycine betaine transport
C1A46_RS01140	COG1174	glycine betaine transport
C1A46_RS01145	COG1732	Glycine betaine
C1A46_RS01155	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
C1A46_RS01170	COG0446	pyridine nucleotide-disulphide oxidoreductase
C1A46_RS01170	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1A46_RS01205	COG1175	transmembrane transport
C1A46_RS01210	COG0395	ABC-type sugar transport system, permease component
C1A46_RS01215	COG3842	ATPase activity
C1A46_RS01220	COG4948	Mandelate Racemase Muconate Lactonizing
C1A46_RS01225	COG3254	rhamnose metabolic process
C1A46_RS01235	COG1028	Short-chain dehydrogenase reductase Sdr
C1A46_RS01245	COG4948	Mandelate Racemase Muconate Lactonizing
C1A46_RS01270	COG0582	viral genome integration into host DNA
C1A46_RS01445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
C1A46_RS01485	COG3617	BRO family, N-terminal domain
C1A46_RS01495	COG3617	BRO family, N-terminal domain
C1A46_RS01505	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1A46_RS01590	COG4191	Histidine kinase
C1A46_RS01600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1A46_RS01605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1A46_RS01620	COG1309	transcriptional regulator
C1A46_RS01635	COG0493	'glutamate synthase
C1A46_RS01665	COG0318	PFAM AMP-dependent synthetase and ligase
C1A46_RS01700	COG2326	polyphosphate kinase activity
C1A46_RS01705	COG5002	protein histidine kinase activity
C1A46_RS01720	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C1A46_RS01730	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
C1A46_RS01745	COG0717	Belongs to the dCTP deaminase family
C1A46_RS01765	COG0534	Mate efflux family protein
C1A46_RS01795	COG0784	Response regulator, receiver
C1A46_RS01795	COG2205	protein histidine kinase activity
C1A46_RS01805	COG0156	8-amino-7-oxononanoate synthase activity
C1A46_RS01830	COG0583	DNA-binding transcription factor activity
C1A46_RS01835	COG1380	Effector of murein hydrolase LrgA
C1A46_RS01840	COG1346	cytolysis
C1A46_RS01880	COG0019	diaminopimelate decarboxylase activity
C1A46_RS01930	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
C1A46_RS01935	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
C1A46_RS01940	COG3257	ureidoglycine aminohydrolase activity
C1A46_RS01945	COG3648	Uricase
C1A46_RS01945	COG3195	allantoin biosynthetic process
C1A46_RS01955	COG2080	2 iron, 2 sulfur cluster binding
C1A46_RS01970	COG0583	DNA-binding transcription factor activity
C1A46_RS01980	COG0402	S-adenosylhomocysteine deaminase activity
C1A46_RS02040	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
C1A46_RS02040	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C1A46_RS02050	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1A46_RS02050	COG2169	Transcriptional regulator
C1A46_RS02055	COG1393	Belongs to the ArsC family
C1A46_RS02065	COG0477	Major facilitator Superfamily
C1A46_RS02070	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
C1A46_RS02095	COG3773	Cell wall hydrolase
C1A46_RS02195	COG0142	geranyltranstransferase activity
C1A46_RS02210	COG0751	glycine-tRNA ligase activity
C1A46_RS02215	COG0009	L-threonylcarbamoyladenylate synthase
C1A46_RS02250	COG1960	acyl-CoA dehydrogenase activity
C1A46_RS02265	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
C1A46_RS02280	COG0484	heat shock protein binding
C1A46_RS02285	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1A46_RS02300	COG1278	Cold shock
C1A46_RS02325	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1A46_RS02325	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C1A46_RS02330	COG0123	including yeast histone deacetylase and acetoin utilization protein
C1A46_RS02335	COG1722	exodeoxyribonuclease VII activity
C1A46_RS02355	COG1741	Belongs to the pirin family
C1A46_RS02365	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
C1A46_RS02390	COG5265	(ABC) transporter
C1A46_RS02400	COG1183	phosphatidylcholine synthase activity
C1A46_RS02405	COG1028	Short-chain dehydrogenase reductase Sdr
C1A46_RS02410	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
C1A46_RS02430	COG0305	Participates in initiation and elongation during chromosome replication
C1A46_RS02435	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
C1A46_RS02465	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C1A46_RS02490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1A46_RS02500	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
C1A46_RS02510	COG1561	YicC-like family, N-terminal region
C1A46_RS02515	COG0194	GDP metabolic process
C1A46_RS02520	COG0312	modulator of DNA gyrase
C1A46_RS02530	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C1A46_RS02535	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C1A46_RS02585	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C1A46_RS02585	COG0678	peroxiredoxin activity
C1A46_RS02605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
C1A46_RS02610	COG0612	Peptidase, M16
C1A46_RS02630	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C1A46_RS02640	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1A46_RS02660	COG1194	a g-specific adenine glycosylase
C1A46_RS02680	COG1196	nuclear chromosome segregation
C1A46_RS02695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C1A46_RS02695	COG0574	Belongs to the PEP-utilizing enzyme family
C1A46_RS02720	COG1268	BioY protein
C1A46_RS02730	COG2351	hydroxyisourate hydrolase activity
C1A46_RS02745	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
C1A46_RS02805	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
C1A46_RS02840	COG2801	Transposase and inactivated derivatives
C1A46_RS02870	COG0662	Cupin 2, conserved barrel domain protein
C1A46_RS02870	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
C1A46_RS02875	COG2942	2-epimerase
C1A46_RS02880	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
C1A46_RS02880	COG0438	transferase activity, transferring glycosyl groups
C1A46_RS02895	COG1129	ABC transporter
C1A46_RS02900	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1A46_RS02905	COG1879	ABC-type sugar transport system periplasmic component
C1A46_RS02915	COG0673	inositol 2-dehydrogenase activity
C1A46_RS02925	COG1070	Carbohydrate kinase
C1A46_RS02970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1A46_RS02980	COG2336	PFAM SpoVT AbrB
C1A46_RS02990	COG2186	Transcriptional regulator
C1A46_RS03005	COG0433	COG0433 Predicted ATPase
C1A46_RS03010	COG1376	ErfK ybiS ycfS ynhG family protein
C1A46_RS03025	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C1A46_RS03045	COG4957	zinc ion binding
C1A46_RS03055	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
C1A46_RS03065	COG0154	amidase activity
C1A46_RS03070	COG2166	iron-sulfur cluster assembly
C1A46_RS03080	COG2205	protein histidine kinase activity
C1A46_RS03110	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1A46_RS03125	COG4695	Portal protein
C1A46_RS03225	COG4235	cytochrome complex assembly
C1A46_RS03235	COG1138	Cytochrome C-type biogenesis protein
C1A46_RS03240	COG3088	subunit of a heme lyase
C1A46_RS03260	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
C1A46_RS03270	COG2205	protein histidine kinase activity
C1A46_RS03270	COG2202	Pas domain
C1A46_RS03275	COG0308	aminopeptidase N
C1A46_RS03290	COG1573	uracil-dna glycosylase
C1A46_RS03305	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
C1A46_RS03310	COG0625	glutathione transferase activity
C1A46_RS03345	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
C1A46_RS03350	COG4974	Belongs to the 'phage' integrase family
C1A46_RS03380	COG3743	rRNA binding
C1A46_RS03380	COG0261	This protein binds to 23S rRNA in the presence of protein L20
C1A46_RS03385	COG0741	lytic transglycosylase activity
C1A46_RS03425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
C1A46_RS03430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1A46_RS03435	COG2223	nitrite transmembrane transporter activity
C1A46_RS03440	COG2207	Transcriptional regulator
C1A46_RS03455	COG0681	Belongs to the peptidase S26 family
C1A46_RS03480	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
C1A46_RS03490	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1A46_RS03510	COG0494	nUDIX hydrolase
C1A46_RS03550	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
C1A46_RS03560	COG0739	heme binding
C1A46_RS03570	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
C1A46_RS03575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1A46_RS03580	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
C1A46_RS03615	COG0488	(ABC) transporter
C1A46_RS03635	COG0314	molybdopterin synthase activity
C1A46_RS03640	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
C1A46_RS03645	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
C1A46_RS03680	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
C1A46_RS03690	COG0243	molybdopterin cofactor binding
C1A46_RS03705	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
C1A46_RS03720	COG0628	permease
C1A46_RS03740	COG1028	Short-chain dehydrogenase reductase Sdr
C1A46_RS03745	COG1620	l-lactate permease
C1A46_RS03865	COG0626	cystathionine gamma-synthase activity
C1A46_RS03900	COG1126	abc transporter atp-binding protein
C1A46_RS03915	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
C1A46_RS03925	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
C1A46_RS03945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1A46_RS03960	COG0113	porphobilinogen synthase activity
C1A46_RS03980	COG2989	Protein conserved in bacteria
C1A46_RS03995	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1A46_RS03995	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C1A46_RS04015	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
C1A46_RS04020	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1A46_RS04110	COG0010	Belongs to the arginase family
C1A46_RS04185	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C1A46_RS04205	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C1A46_RS04210	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C1A46_RS04250	COG1007	ATP synthesis coupled electron transport
C1A46_RS04265	COG0346	lactoylglutathione lyase activity
C1A46_RS04320	COG0483	inositol monophosphate 1-phosphatase activity
C1A46_RS04325	COG2814	Major facilitator Superfamily
C1A46_RS04365	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
C1A46_RS04395	COG2514	catechol 2,3-dioxygenase activity
C1A46_RS04400	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C1A46_RS04420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1A46_RS04425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C1A46_RS04430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
C1A46_RS04450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1A46_RS04455	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
C1A46_RS04460	COG3454	Phosphonate metabolism
C1A46_RS04465	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
C1A46_RS04470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1A46_RS04475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
C1A46_RS04500	COG1522	sequence-specific DNA binding
C1A46_RS04505	COG1573	uracil-dna glycosylase
C1A46_RS04535	COG0316	Belongs to the HesB IscA family
C1A46_RS04555	COG1472	Belongs to the glycosyl hydrolase 3 family
C1A46_RS04560	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
C1A46_RS04565	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
C1A46_RS04575	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
C1A46_RS04580	COG0805	protein transport
C1A46_RS04595	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1A46_RS04615	COG1862	Preprotein translocase
C1A46_RS04685	COG4765	Protein conserved in bacteria
C1A46_RS04695	COG0439	Biotin carboxylase
C1A46_RS04700	COG0511	ligase activity, forming carbon-carbon bonds
C1A46_RS04715	COG0501	Belongs to the peptidase M48B family
C1A46_RS04725	COG0436	Aminotransferase
C1A46_RS04730	COG1530	ribonuclease E activity
C1A46_RS04740	COG0860	N-Acetylmuramoyl-L-alanine amidase
C1A46_RS04745	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
C1A46_RS04770	COG2833	Protein of unknown function (DUF455)
C1A46_RS04775	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
C1A46_RS04800	COG2945	thiolester hydrolase activity
C1A46_RS04810	COG0719	Fe-S assembly protein
C1A46_RS04815	COG0396	ATPase activity
C1A46_RS04820	COG0719	Fe-S assembly protein
C1A46_RS04825	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
C1A46_RS04830	COG2151	metal-sulfur cluster biosynthetic enzyme
C1A46_RS04845	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
C1A46_RS04850	COG0513	Belongs to the DEAD box helicase family
C1A46_RS04855	COG0316	Belongs to the HesB IscA family
C1A46_RS04875	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
C1A46_RS04945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1A46_RS05105	COG1393	Belongs to the ArsC family
C1A46_RS05135	COG0084	hydrolase, TatD family'
C1A46_RS05170	COG0174	glutamine synthetase
C1A46_RS05175	COG0347	Belongs to the P(II) protein family
C1A46_RS05180	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
C1A46_RS05180	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
C1A46_RS05190	COG0546	phosphoglycolate phosphatase activity
C1A46_RS05195	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
C1A46_RS05210	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
C1A46_RS05215	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
C1A46_RS05235	COG0281	malic enzyme
C1A46_RS05235	COG0280	phosphate acetyltransferase
C1A46_RS05245	COG4948	Mandelate Racemase Muconate Lactonizing
C1A46_RS05250	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
C1A46_RS05260	COG1127	ABC transporter
C1A46_RS05290	COG0633	Ferredoxin
C1A46_RS05295	COG0492	ferredoxin-NADP+ reductase activity
C1A46_RS05310	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
C1A46_RS05320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
C1A46_RS05335	COG3106	COG3106 Predicted ATPase
C1A46_RS05360	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
C1A46_RS05370	COG0668	transmembrane transport
C1A46_RS05375	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C1A46_RS05415	COG1546	Belongs to the CinA family
C1A46_RS05415	COG1058	Belongs to the CinA family
C1A46_RS05435	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
C1A46_RS05440	COG0513	Belongs to the DEAD box helicase family
C1A46_RS05445	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C1A46_RS05450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C1A46_RS05455	COG2897	thiosulfate sulfurtransferase activity
C1A46_RS05465	COG0427	acetyl-CoA hydrolase
C1A46_RS05490	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
C1A46_RS05505	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
C1A46_RS05515	COG3956	TIGRFAM MazG family protein
C1A46_RS05520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
C1A46_RS05540	COG1686	Belongs to the peptidase S11 family
C1A46_RS05565	COG1752	Esterase of the alpha-beta hydrolase superfamily
C1A46_RS05620	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
C1A46_RS05635	COG3617	BRO family, N-terminal domain
C1A46_RS05650	COG1960	acyl-CoA dehydrogenase activity
C1A46_RS05655	COG0583	DNA-binding transcription factor activity
C1A46_RS05660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1A46_RS05665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
C1A46_RS05670	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1A46_RS05705	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C1A46_RS05710	COG2095	MarC family integral membrane protein
C1A46_RS05720	COG2188	Transcriptional regulator
C1A46_RS05770	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
C1A46_RS05790	COG0569	domain protein
C1A46_RS05795	COG2204	response regulator
C1A46_RS05800	COG5000	phosphorelay sensor kinase activity
C1A46_RS05805	COG2204	response regulator
C1A46_RS05810	COG3852	Histidine kinase
C1A46_RS05825	COG1546	Belongs to the CinA family
C1A46_RS05825	COG1058	Belongs to the CinA family
C1A46_RS05835	COG2867	negative regulation of translational initiation
C1A46_RS05850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C1A46_RS05855	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1A46_RS05860	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1A46_RS05860	COG0022	dehydrogenase e1 component
C1A46_RS05865	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C1A46_RS05870	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C1A46_RS05915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1A46_RS05935	COG0303	'Molybdopterin
C1A46_RS05955	COG0372	Belongs to the citrate synthase family
C1A46_RS05960	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
C1A46_RS05985	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1A46_RS06040	COG0584	glycerophosphoryl diester phosphodiesterase
C1A46_RS06050	COG0537	adenosine 5'-monophosphoramidase activity
C1A46_RS06070	COG1686	Belongs to the peptidase S11 family
C1A46_RS06085	COG1760	l-serine dehydratase
C1A46_RS06140	COG3800	Transcriptional regulator
C1A46_RS06140	COG1396	sequence-specific DNA binding
C1A46_RS06145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
C1A46_RS06150	COG4770	biotin carboxylase activity
C1A46_RS06155	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1A46_RS06155	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
C1A46_RS06170	COG2358	TRAP transporter, solute receptor (TAXI family
C1A46_RS06180	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
C1A46_RS06185	COG0693	protein deglycase activity
C1A46_RS06195	COG0538	isocitrate dehydrogenase activity
C1A46_RS06200	COG1785	Belongs to the alkaline phosphatase family
C1A46_RS06215	COG2885	chlorophyll binding
C1A46_RS06225	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
C1A46_RS06230	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C1A46_RS06280	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C1A46_RS06345	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
C1A46_RS06435	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C1A46_RS06465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
C1A46_RS06470	COG0516	GMP reductase activity
C1A46_RS06470	COG0517	IMP dehydrogenase activity
C1A46_RS06520	COG0346	lactoylglutathione lyase activity
C1A46_RS06540	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1A46_RS06545	COG1494	fructose-1,6-bisphosphatase
C1A46_RS06555	COG0436	Aminotransferase
C1A46_RS06590	COG0024	Methionine aminopeptidase
C1A46_RS06765	COG0583	DNA-binding transcription factor activity
C1A46_RS06790	COG3264	Mechanosensitive ion channel
C1A46_RS06790	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
C1A46_RS06805	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1A46_RS06805	COG4651	solute:proton antiporter activity
C1A46_RS06825	COG4208	sulfate ABC transporter
C1A46_RS06830	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
C1A46_RS06835	COG4150	thiosulfate binding
C1A46_RS06845	COG1253	flavin adenine dinucleotide binding
C1A46_RS06850	COG0586	Pfam SNARE associated Golgi protein
C1A46_RS06870	COG4154	Belongs to the RbsD FucU family
C1A46_RS06875	COG1028	Short-chain dehydrogenase reductase Sdr
C1A46_RS06900	COG1120	ATPase activity
C1A46_RS06905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1A46_RS06920	COG0842	Transport permease protein
C1A46_RS06930	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1A46_RS06945	COG1649	PFAM Uncharacterised BCR, COG1649
C1A46_RS06985	COG4413	Urea transporter
C1A46_RS06995	COG0310	cobalt ion transport
C1A46_RS07035	COG0384	phenazine biosynthesis protein PhzF
C1A46_RS07060	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1A46_RS07095	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C1A46_RS07100	COG0440	acetolactate synthase activity
C1A46_RS07105	COG0028	Belongs to the TPP enzyme family
C1A46_RS07120	COG0560	Phosphoserine phosphatase
C1A46_RS07125	COG2081	HI0933 family
C1A46_RS07140	COG0330	HflC and HflK could
C1A46_RS07205	COG0277	FAD linked oxidase domain protein
C1A46_RS07220	COG0210	DNA helicase
C1A46_RS07235	COG1999	signal sequence binding
C1A46_RS07245	COG0006	proline dipeptidase activity
C1A46_RS07265	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C1A46_RS07280	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C1A46_RS07285	COG0849	cell division
C1A46_RS07290	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
C1A46_RS07295	COG1181	Belongs to the D-alanine--D-alanine ligase family
C1A46_RS07360	COG1914	H( )-stimulated, divalent metal cation uptake system
C1A46_RS07375	COG3023	N-Acetylmuramoyl-L-alanine amidase
C1A46_RS07380	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
C1A46_RS07410	COG0640	Transcriptional regulator
C1A46_RS07420	COG0477	Major facilitator Superfamily
C1A46_RS07445	COG2267	carboxylic ester hydrolase activity
C1A46_RS07470	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C1A46_RS07475	COG2824	Alkylphosphonate utilization operon protein PhnA
C1A46_RS07480	COG1335	isochorismatase
C1A46_RS07505	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
C1A46_RS07545	COG2968	Membrane
C1A46_RS07565	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1A46_RS07575	COG0358	DNA primase activity
C1A46_RS07595	COG2321	neutral zinc metallopeptidase
C1A46_RS07610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C1A46_RS07620	COG1136	(ABC) transporter
C1A46_RS07630	COG1278	Cold shock
C1A46_RS07635	COG0625	glutathione transferase activity
C1A46_RS07640	COG0436	Aminotransferase
C1A46_RS07655	COG0583	DNA-binding transcription factor activity
C1A46_RS07660	COG0492	ferredoxin-NADP+ reductase activity
C1A46_RS07665	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
C1A46_RS07670	COG1522	sequence-specific DNA binding
C1A46_RS07720	COG0556	nucleotide-excision repair
C1A46_RS07725	COG0739	heme binding
C1A46_RS07725	COG1196	nuclear chromosome segregation
C1A46_RS07725	COG0741	lytic transglycosylase activity
C1A46_RS07730	COG1278	Cold shock
C1A46_RS07740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
C1A46_RS07760	COG1846	Transcriptional regulator
C1A46_RS07765	COG0745	RESPONSE REGULATOR receiver
C1A46_RS07770	COG2205	protein histidine kinase activity
C1A46_RS07780	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C1A46_RS07815	COG1496	oxidoreductase activity
C1A46_RS07835	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C1A46_RS07860	COG0012	GTP binding
C1A46_RS07865	COG2030	dehydratase
C1A46_RS07880	COG2857	Cytochrome c1
C1A46_RS07880	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
C1A46_RS07895	COG1132	(ABC) transporter
C1A46_RS07900	COG1132	(ABC) transporter
C1A46_RS07905	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
C1A46_RS07925	COG3153	acetyltransferase
C1A46_RS07940	COG0617	tRNA 3'-terminal CCA addition
C1A46_RS07955	COG0714	Associated with various cellular activities
C1A46_RS07980	COG0435	Glutathione S-transferase
C1A46_RS07985	COG3047	cAMP biosynthetic process
C1A46_RS07990	COG1051	belongs to the nudix hydrolase family
C1A46_RS08005	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
C1A46_RS08010	COG0512	Glutamine amidotransferase of anthranilate synthase
C1A46_RS08010	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
C1A46_RS08020	COG1522	sequence-specific DNA binding
C1A46_RS08050	COG4176	ABC-type proline glycine betaine transport system permease component
C1A46_RS08055	COG4175	Glycine betaine
C1A46_RS08060	COG4608	Belongs to the ABC transporter superfamily
C1A46_RS08065	COG0444	Belongs to the ABC transporter superfamily
C1A46_RS08070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1A46_RS08075	COG0601	transmembrane transport
C1A46_RS08210	COG1177	transmembrane transport
C1A46_RS08220	COG3842	ATPase activity
C1A46_RS08240	COG2224	Isocitrate lyase
C1A46_RS08255	COG1028	Short-chain dehydrogenase reductase Sdr
C1A46_RS08260	COG1028	Short-chain dehydrogenase reductase Sdr
C1A46_RS08280	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C1A46_RS08300	COG2376	Dihydroxyacetone kinase
C1A46_RS08305	COG2390	Transcriptional regulator
C1A46_RS08310	COG1461	Dihydroxyacetone kinase
C1A46_RS08315	COG2376	Dihydroxyacetone kinase
C1A46_RS08320	COG1028	Short-chain dehydrogenase reductase Sdr
C1A46_RS08325	COG1879	ABC-type sugar transport system periplasmic component
C1A46_RS08330	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1A46_RS08335	COG1129	ABC transporter
C1A46_RS08390	COG1012	belongs to the aldehyde dehydrogenase family
C1A46_RS08415	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C1A46_RS08430	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1A46_RS08435	COG0564	pseudouridine synthase activity
C1A46_RS08470	COG0784	Response regulator, receiver
C1A46_RS08485	COG3920	Histidine kinase
C1A46_RS08515	COG0848	biopolymer transport protein
C1A46_RS08535	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1A46_RS08545	COG1522	sequence-specific DNA binding
C1A46_RS08565	COG0477	Major facilitator Superfamily
C1A46_RS08585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1A46_RS08595	COG0385	Bile acid
C1A46_RS08610	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C1A46_RS08625	COG2885	chlorophyll binding
C1A46_RS08645	COG0848	biopolymer transport protein
C1A46_RS08655	COG0824	Thioesterase
C1A46_RS08700	COG0483	inositol monophosphate 1-phosphatase activity
C1A46_RS08715	COG1132	(ABC) transporter
C1A46_RS08745	COG1253	flavin adenine dinucleotide binding
C1A46_RS08750	COG1692	metallophosphoesterase
C1A46_RS08800	COG1028	Short-chain dehydrogenase reductase Sdr
C1A46_RS08825	COG0604	alcohol dehydrogenase
C1A46_RS08825	COG1028	Short-chain dehydrogenase reductase Sdr
C1A46_RS08825	COG3321	synthase
C1A46_RS08860	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
C1A46_RS08865	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
C1A46_RS08875	COG0457	Tetratricopeptide repeat
C1A46_RS08880	COG0469	pyruvate kinase activity
C1A46_RS08895	COG3750	Belongs to the UPF0335 family
C1A46_RS08900	COG0488	(ABC) transporter
C1A46_RS08940	COG2258	MOSC domain
C1A46_RS08945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C1A46_RS08960	COG1329	Transcriptional regulator
C1A46_RS08965	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
C1A46_RS08990	COG0183	Belongs to the thiolase family
C1A46_RS09010	COG0142	geranyltranstransferase activity
C1A46_RS09020	COG1028	Short-chain dehydrogenase reductase Sdr
C1A46_RS09025	COG0738	Major facilitator superfamily
C1A46_RS09030	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
C1A46_RS09145	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C1A46_RS09155	COG5425	PFAM Usg family protein
C1A46_RS09175	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1A46_RS09175	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1A46_RS09210	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
C1A46_RS09215	COG1704	LemA family
C1A46_RS09225	COG0287	Prephenate dehydrogenase
C1A46_RS09225	COG1605	Chorismate mutase
C1A46_RS09230	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C1A46_RS09265	COG0583	DNA-binding transcription factor activity
C1A46_RS09290	COG0793	Belongs to the peptidase S41A family
C1A46_RS09310	COG0799	negative regulation of ribosome biogenesis
C1A46_RS09375	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
C1A46_RS09440	COG0739	heme binding
C1A46_RS09470	COG2890	protein-(glutamine-N5) methyltransferase activity
C1A46_RS09485	COG0527	aspartate kinase activity
C1A46_RS09515	COG1040	competence protein
C1A46_RS09575	COG2264	protein methyltransferase activity
C1A46_RS09580	COG0697	spore germination
C1A46_RS09585	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
C1A46_RS09595	COG0004	ammonium transporteR
C1A46_RS09600	COG1946	Acyl-CoA thioesterase
C1A46_RS09605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1A46_RS09720	COG1280	lysine exporter protein (LysE YggA)
C1A46_RS09730	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1A46_RS09740	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
C1A46_RS09760	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
C1A46_RS09780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C1A46_RS09785	COG0552	protein localization to endoplasmic reticulum
C1A46_RS09815	COG0494	nUDIX hydrolase
C1A46_RS09830	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1A46_RS09880	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1A46_RS09885	COG0765	amino acid transport
C1A46_RS09890	COG0765	amino acid transport
C1A46_RS09910	COG1126	abc transporter atp-binding protein
C1A46_RS09920	COG1802	Transcriptional regulator
C1A46_RS09950	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1A46_RS09960	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
C1A46_RS09965	COG2086	electron transfer activity
C1A46_RS09975	COG0720	synthase
C1A46_RS09980	COG0602	queuosine metabolic process
C1A46_RS09995	COG0300	oxidoreductase activity
C1A46_RS10010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
C1A46_RS10045	COG2226	methyltransferase
C1A46_RS10055	COG0287	Prephenate dehydrogenase
C1A46_RS10085	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C1A46_RS10105	COG2884	Cell division ATP-binding protein ftsE
C1A46_RS10125	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
C1A46_RS10180	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
C1A46_RS10195	COG0789	Transcriptional regulator
C1A46_RS10245	COG4536	flavin adenine dinucleotide binding
C1A46_RS10285	COG0523	cobalamin synthesis protein
C1A46_RS10290	COG1686	Belongs to the peptidase S11 family
C1A46_RS10295	COG1473	amidohydrolase
C1A46_RS10305	COG1028	Short-chain dehydrogenase reductase Sdr
C1A46_RS10325	COG1028	Short-chain dehydrogenase reductase Sdr
C1A46_RS10335	COG1012	belongs to the aldehyde dehydrogenase family
C1A46_RS10340	COG1024	Enoyl-CoA hydratase
C1A46_RS10355	COG1609	Transcriptional regulator
C1A46_RS10365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
C1A46_RS10385	COG4120	Belongs to the binding-protein-dependent transport system permease family
C1A46_RS10390	COG0410	ABC transporter
C1A46_RS10425	COG1331	Highly conserved protein containing a thioredoxin domain
C1A46_RS10430	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C1A46_RS10435	COG1981	membrane
C1A46_RS10485	COG4395	Tim44
C1A46_RS10495	COG2840	Smr protein MutS2
C1A46_RS10500	COG1396	sequence-specific DNA binding
C1A46_RS10570	COG0745	RESPONSE REGULATOR receiver
C1A46_RS10575	COG2205	protein histidine kinase activity
C1A46_RS10590	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C1A46_RS10590	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1A46_RS10595	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C1A46_RS10615	COG2205	protein histidine kinase activity
C1A46_RS10620	COG3178	'Phosphotransferase
C1A46_RS10625	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
C1A46_RS10630	COG2887	Belongs to the helicase family. UvrD subfamily
C1A46_RS10635	COG1074	ATP-dependent DNA helicase activity
C1A46_RS10645	COG0285	dihydrofolate synthase activity
C1A46_RS10675	COG1434	Gram-negative-bacterium-type cell wall biogenesis
C1A46_RS10700	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
C1A46_RS10770	COG3386	PFAM SMP-30 Gluconolaconase
C1A46_RS10790	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
C1A46_RS10800	COG2832	Protein of unknown function (DUF454)
C1A46_RS10805	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
C1A46_RS10810	COG0573	inorganic phosphate transmembrane transporter activity
C1A46_RS10820	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
C1A46_RS10825	COG0704	Plays a role in the regulation of phosphate uptake
C1A46_RS10830	COG0745	RESPONSE REGULATOR receiver
C1A46_RS10835	COG3773	Cell wall hydrolase
C1A46_RS10845	COG2309	aminopeptidase activity
C1A46_RS10850	COG0783	Belongs to the Dps family
C1A46_RS10860	COG0456	acetyltransferase
C1A46_RS10890	COG0815	Transfers the fatty acyl group on membrane lipoproteins
C1A46_RS10895	COG1396	sequence-specific DNA binding
C1A46_RS10900	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
C1A46_RS10915	COG0195	Participates in both transcription termination and antitermination
C1A46_RS10915	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
C1A46_RS10955	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C1A46_RS10995	COG0791	NLP P60 protein
C1A46_RS11005	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
C1A46_RS11020	COG1024	Enoyl-CoA hydratase
C1A46_RS11035	COG1414	Transcriptional regulator
C1A46_RS11045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1A46_RS11050	COG1957	nucleoside hydrolase
C1A46_RS11065	COG3845	ABC transporter
C1A46_RS11070	COG1744	ABC transporter substrate-binding protein PnrA-like
C1A46_RS11085	COG1028	Short-chain dehydrogenase reductase Sdr
C1A46_RS11090	COG3433	isochorismatase activity
C1A46_RS11090	COG1535	isochorismatase
C1A46_RS11095	COG1021	2,3-dihydroxybenzoate-AMP ligase
C1A46_RS11100	COG1169	isochorismate synthase
C1A46_RS11105	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1A46_RS11105	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
C1A46_RS11110	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C1A46_RS11130	COG4944	Protein of unknown function (DUF1109)
C1A46_RS11135	COG2186	Transcriptional regulator
C1A46_RS11170	COG1028	Short-chain dehydrogenase reductase Sdr
C1A46_RS11175	COG1028	Short-chain dehydrogenase reductase Sdr
C1A46_RS11180	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
C1A46_RS11185	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1A46_RS11190	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1A46_RS11225	COG4191	Histidine kinase
C1A46_RS11230	COG4566	intracellular signal transduction
C1A46_RS11280	COG0071	Belongs to the small heat shock protein (HSP20) family
C1A46_RS11295	COG0070	glutamate synthase
C1A46_RS11295	COG0069	glutamate synthase activity
C1A46_RS11295	COG0067	glutamate synthase
C1A46_RS11305	COG1113	amino acid transport
C1A46_RS11380	COG2951	lytic endotransglycosylase activity
C1A46_RS11385	COG1210	Utp--glucose-1-phosphate uridylyltransferase
C1A46_RS11405	COG0330	HflC and HflK could
C1A46_RS11420	COG5310	Homospermidine synthase
C1A46_RS11440	COG2204	response regulator
C1A46_RS11450	COG3108	Peptidase M15
C1A46_RS11455	COG0800	Aldolase
C1A46_RS11475	COG0725	ABC transporter, periplasmic molybdate-binding protein
C1A46_RS11480	COG4149	molybdate abc transporter
C1A46_RS11505	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
C1A46_RS11515	COG0583	DNA-binding transcription factor activity
C1A46_RS11520	COG0154	amidase activity
C1A46_RS11530	COG3206	protein involved in exopolysaccharide biosynthesis
C1A46_RS11530	COG0489	protein tyrosine kinase activity
C1A46_RS11565	COG0673	inositol 2-dehydrogenase activity
C1A46_RS11575	COG3842	ATPase activity
C1A46_RS11605	COG1309	transcriptional regulator
C1A46_RS11620	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1A46_RS11630	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C1A46_RS11650	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
C1A46_RS11660	COG4786	Flagellar basal body rod
C1A46_RS11665	COG1157	protein secretion by the type III secretion system
C1A46_RS11675	COG0671	phosphoesterase, PA-phosphatase related
C1A46_RS11690	COG0463	Glycosyl transferase, family 2
C1A46_RS11700	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
C1A46_RS11715	COG2963	transposase activity
C1A46_RS11720	COG2271	Major facilitator Superfamily
C1A46_RS11725	COG0235	Class ii aldolase
C1A46_RS11730	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
C1A46_RS11735	COG1349	DNA-binding transcription factor activity
C1A46_RS11740	COG3622	Belongs to the hyi family
C1A46_RS11745	COG3395	kinase activity
C1A46_RS11755	COG1815	bacterial-type flagellum-dependent cell motility
C1A46_RS11760	COG1558	bacterial-type flagellum-dependent cell motility
C1A46_RS11770	COG4786	Flagellar basal body rod
C1A46_RS11775	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C1A46_RS11805	COG1338	Plays a role in the flagellum-specific transport system
C1A46_RS11825	COG0583	DNA-binding transcription factor activity
C1A46_RS11835	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
C1A46_RS11850	COG3038	cytochrome b561
C1A46_RS11880	COG2186	Transcriptional regulator
C1A46_RS11885	COG0583	DNA-binding transcription factor activity
C1A46_RS11890	COG0277	FAD linked oxidase domain protein
C1A46_RS11900	COG0247	lactate metabolic process
C1A46_RS11905	COG0656	L-ascorbic acid biosynthetic process
C1A46_RS11920	COG2818	Glycosylase
C1A46_RS11955	COG2259	Doxx family
C1A46_RS11995	COG0196	riboflavin kinase activity
C1A46_RS12015	COG0590	tRNA wobble adenosine to inosine editing
C1A46_RS12025	COG0742	ribosomal rna small subunit methyltransferase
C1A46_RS12030	COG0612	Peptidase, M16
C1A46_RS12050	COG0475	glutathione-regulated potassium exporter activity
C1A46_RS12050	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
C1A46_RS12055	COG0312	modulator of DNA gyrase
C1A46_RS12075	COG1519	Transferase
C1A46_RS12100	COG2814	Major facilitator Superfamily
C1A46_RS12105	COG1960	acyl-CoA dehydrogenase activity
C1A46_RS12125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1A46_RS12175	COG1477	protein flavinylation
C1A46_RS12225	COG1129	ABC transporter
C1A46_RS12235	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1A46_RS12240	COG0251	oxidation-reduction process
C1A46_RS12250	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
C1A46_RS12255	COG0400	carboxylic ester hydrolase activity
C1A46_RS12265	COG0523	cobalamin synthesis protein
C1A46_RS12285	COG1609	Transcriptional regulator
C1A46_RS12290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
C1A46_RS12295	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
C1A46_RS12300	COG1028	Short-chain dehydrogenase reductase Sdr
C1A46_RS12390	COG2011	ABC-type metal ion transport system permease component
C1A46_RS12450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
C1A46_RS12455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1A46_RS12465	COG0028	Belongs to the TPP enzyme family
C1A46_RS12470	COG2186	Transcriptional regulator
C1A46_RS12475	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1A46_RS12490	COG0129	dihydroxy-acid dehydratase activity
C1A46_RS12495	COG3734	2-keto-3-deoxy-galactonokinase
C1A46_RS12500	COG0800	Aldolase
C1A46_RS12510	COG1129	ABC transporter
C1A46_RS12515	COG4214	carbohydrate transport
C1A46_RS12550	COG0402	S-adenosylhomocysteine deaminase activity
C1A46_RS12560	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1A46_RS12580	COG1522	sequence-specific DNA binding
C1A46_RS12595	COG0243	molybdopterin cofactor binding
C1A46_RS12615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
C1A46_RS12625	COG2188	Transcriptional regulator
C1A46_RS12635	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
C1A46_RS12655	COG1012	belongs to the aldehyde dehydrogenase family
C1A46_RS12660	COG5383	Protein conserved in bacteria
C1A46_RS12675	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1A46_RS12685	COG0640	Transcriptional regulator
C1A46_RS12690	COG1902	pentaerythritol trinitrate reductase activity
C1A46_RS12700	COG0010	Belongs to the arginase family
C1A46_RS12755	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
C1A46_RS12755	COG2169	Transcriptional regulator
C1A46_RS12765	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C1A46_RS12770	COG1846	Transcriptional regulator
C1A46_RS12775	COG1764	response to oxidative stress
C1A46_RS12810	COG0339	signal peptide processing
C1A46_RS12820	COG2239	Acts as a magnesium transporter
C1A46_RS12825	COG1217	gtp-binding protein TYPA
C1A46_RS12860	COG1349	DNA-binding transcription factor activity
C1A46_RS12895	COG1129	ABC transporter
C1A46_RS12900	COG1172	Belongs to the binding-protein-dependent transport system permease family
C1A46_RS12915	COG1349	DNA-binding transcription factor activity
C1A46_RS12925	COG0277	FAD linked oxidase domain protein
C1A46_RS12935	COG1088	dTDP-glucose 4,6-dehydratase activity
C1A46_RS12975	COG3586	endonuclease activity
C1A46_RS12985	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
C1A46_RS13060	COG1201	RNA secondary structure unwinding
C1A46_RS13075	COG0730	response to heat
C1A46_RS13085	COG0789	Transcriptional regulator
C1A46_RS13090	COG1993	acr, cog1993
C1A46_RS13125	COG1802	Transcriptional regulator
C1A46_RS13130	COG1904	glucuronate isomerase
C1A46_RS13140	COG0246	Mannitol dehydrogenase
C1A46_RS13150	COG3842	ATPase activity
C1A46_RS13155	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1A46_RS13160	COG4208	sulfate ABC transporter
C1A46_RS13165	COG2721	sulfolactate sulfo-lyase activity
C1A46_RS13180	COG0601	transmembrane transport
C1A46_RS13185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1A46_RS13230	COG1960	acyl-CoA dehydrogenase activity
C1A46_RS13235	COG0183	Belongs to the thiolase family
C1A46_RS13240	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1A46_RS13240	COG1024	Enoyl-CoA hydratase
C1A46_RS13265	COG0288	reversible hydration of carbon dioxide
C1A46_RS13275	COG0747	negative chemotaxis
C1A46_RS13285	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1A46_RS13290	COG0444	Belongs to the ABC transporter superfamily
C1A46_RS13295	COG4172	Belongs to the ABC transporter superfamily
C1A46_RS13310	COG0129	dihydroxy-acid dehydratase activity
C1A46_RS13315	COG0363	glucosamine-6-phosphate deaminase activity
C1A46_RS13320	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C1A46_RS13365	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1A46_RS13375	COG0174	glutamine synthetase
C1A46_RS13390	COG0583	DNA-binding transcription factor activity
C1A46_RS13410	COG1846	Transcriptional regulator
C1A46_RS13440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1A46_RS13445	COG1120	ATPase activity
C1A46_RS13460	COG0251	oxidation-reduction process
C1A46_RS13465	COG0395	ABC-type sugar transport system, permease component
C1A46_RS13490	COG1737	Transcriptional regulator
C1A46_RS13515	COG4176	ABC-type proline glycine betaine transport system permease component
C1A46_RS13570	COG0404	The glycine cleavage system catalyzes the degradation of glycine
C1A46_RS13575	COG0509	glycine decarboxylation via glycine cleavage system
C1A46_RS13595	COG1522	sequence-specific DNA binding
C1A46_RS13605	COG1840	ABC-type Fe3 transport system, periplasmic component
C1A46_RS13625	COG3718	enzyme involved in inositol metabolism
C1A46_RS13635	COG3962	Belongs to the TPP enzyme family
C1A46_RS13640	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
C1A46_RS13650	COG0673	inositol 2-dehydrogenase activity
C1A46_RS13665	COG0450	alkyl hydroperoxide reductase
C1A46_RS13675	COG0477	Major facilitator Superfamily
C1A46_RS13690	COG2132	Multicopper oxidase
C1A46_RS13715	COG1840	ABC-type Fe3 transport system, periplasmic component
C1A46_RS13750	COG1175	transmembrane transport
C1A46_RS13760	COG3842	ATPase activity
C1A46_RS13770	COG0477	Major facilitator Superfamily
C1A46_RS13785	COG0248	Ppx GppA phosphatase
C1A46_RS13790	COG1126	abc transporter atp-binding protein
C1A46_RS13795	COG0765	amino acid transport
C1A46_RS13800	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1A46_RS13815	COG4604	ABC transporter, ATP-binding protein
C1A46_RS13820	COG4605	iron ion homeostasis
C1A46_RS13825	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
C1A46_RS13830	COG4607	ABC-type enterochelin transport system periplasmic component
C1A46_RS13885	COG2252	PERMEase
C1A46_RS13895	COG3273	potassium ion transport
C1A46_RS13895	COG0471	metal ion transport
C1A46_RS13960	COG3485	protocatechuate 3,4-dioxygenase
C1A46_RS13965	COG3485	protocatechuate 3,4-dioxygenase
C1A46_RS13970	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
C1A46_RS13975	COG2267	carboxylic ester hydrolase activity
C1A46_RS13980	COG0583	DNA-binding transcription factor activity
C1A46_RS13995	COG1414	Transcriptional regulator
C1A46_RS14005	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
C1A46_RS14035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
C1A46_RS14040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
C1A46_RS14060	COG2176	DNA-directed DNA polymerase activity
C1A46_RS14100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
C1A46_RS14105	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
C1A46_RS14145	COG0557	exoribonuclease II activity
C1A46_RS14150	COG1754	DNA topoisomerase type I activity
C1A46_RS14150	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C1A46_RS14155	COG0758	DNA mediated transformation
C1A46_RS14165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
C1A46_RS14175	COG1960	acyl-CoA dehydrogenase activity
C1A46_RS14210	COG0187	DNA topoisomerase II activity
C1A46_RS14215	COG0697	spore germination
C1A46_RS14255	COG0785	Cytochrome C biogenesis protein
C1A46_RS14275	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
C1A46_RS14280	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C1A46_RS14285	COG0346	lactoylglutathione lyase activity
C1A46_RS14310	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
C1A46_RS14315	COG1183	phosphatidylcholine synthase activity
C1A46_RS14330	COG3845	ABC transporter
C1A46_RS14335	COG4603	Belongs to the binding-protein-dependent transport system permease family
C1A46_RS14370	COG1959	2 iron, 2 sulfur cluster binding
C1A46_RS14375	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
C1A46_RS14400	COG2963	transposase activity
C1A46_RS14405	COG3436	PFAM IS66 Orf2 family protein
C1A46_RS14410	COG2433	Pfam Transposase IS66
C1A46_RS14450	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
C1A46_RS14490	COG0601	transmembrane transport
C1A46_RS14495	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1A46_RS14500	COG4172	Belongs to the ABC transporter superfamily
C1A46_RS14505	COG3145	DNA-N1-methyladenine dioxygenase activity
C1A46_RS14520	COG0477	Major facilitator Superfamily
C1A46_RS14560	COG0022	dehydrogenase e1 component
C1A46_RS14580	COG0673	inositol 2-dehydrogenase activity
C1A46_RS14585	COG0395	ABC-type sugar transport system, permease component
C1A46_RS14590	COG1175	transmembrane transport
C1A46_RS14605	COG2971	BadF BadG BcrA BcrD
C1A46_RS14610	COG2188	Transcriptional regulator
C1A46_RS14620	COG1294	oxidase, subunit
C1A46_RS14625	COG1271	oxidase subunit
C1A46_RS14630	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
C1A46_RS14635	COG4988	ABC transporter
C1A46_RS14655	COG2212	antiporter activity
C1A46_RS14660	COG1863	multisubunit Na H antiporter MnhE subunit
C1A46_RS14665	COG0651	ATP synthesis coupled electron transport
C1A46_RS14670	COG1006	Multisubunit Na H antiporter MnhC subunit
C1A46_RS14675	COG2111	Na H antiporter
C1A46_RS14675	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C1A46_RS14690	COG0521	Mo-molybdopterin cofactor biosynthetic process
C1A46_RS14705	COG0156	8-amino-7-oxononanoate synthase activity
C1A46_RS14715	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C1A46_RS14720	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
C1A46_RS14740	COG1115	amino acid carrier protein
C1A46_RS14755	COG1252	NADH dehydrogenase
C1A46_RS14785	COG2205	protein histidine kinase activity
C1A46_RS14820	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1A46_RS14830	COG0842	Transport permease protein
C1A46_RS14875	COG0640	Transcriptional regulator
C1A46_RS14880	COG2354	Protein conserved in bacteria
C1A46_RS14885	COG0242	peptide deformylase activity
C1A46_RS14890	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
C1A46_RS14905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
C1A46_RS14910	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
C1A46_RS14920	COG0183	Belongs to the thiolase family
C1A46_RS14925	COG1960	acyl-CoA dehydrogenase activity
C1A46_RS14930	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
C1A46_RS14935	COG0583	DNA-binding transcription factor activity
C1A46_RS14955	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
C1A46_RS14975	COG2197	response regulator
C1A46_RS14995	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
C1A46_RS14995	COG1940	carbohydrate kinase activity
C1A46_RS15000	COG2186	Transcriptional regulator
C1A46_RS15025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1A46_RS15070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
C1A46_RS15075	COG1028	Short-chain dehydrogenase reductase Sdr
C1A46_RS15100	COG3321	synthase
C1A46_RS15100	COG1028	Short-chain dehydrogenase reductase Sdr
C1A46_RS15100	COG0604	alcohol dehydrogenase
C1A46_RS15105	COG1802	Transcriptional regulator
C1A46_RS15110	COG2124	cytochrome p450
C1A46_RS15115	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C1A46_RS15120	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
C1A46_RS15170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
C1A46_RS15170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
C1A46_RS15180	COG0753	catalase activity
C1A46_RS15185	COG0583	DNA-binding transcription factor activity
C1A46_RS15190	COG3258	Cytochrome c
C1A46_RS15210	COG3191	aminopeptidase activity
C1A46_RS15215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
C1A46_RS15235	COG4943	cyclic-guanylate-specific phosphodiesterase activity
C1A46_RS15255	COG0531	amino acid
C1A46_RS15305	COG1177	transmembrane transport
C1A46_RS15310	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1A46_RS15315	COG3842	ATPase activity
C1A46_RS15340	COG2894	cell division
C1A46_RS15370	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
C1A46_RS15390	COG0673	inositol 2-dehydrogenase activity
C1A46_RS15415	COG1653	transport
C1A46_RS15420	COG1609	Transcriptional regulator
C1A46_RS15430	COG2223	nitrite transmembrane transporter activity
C1A46_RS15435	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
C1A46_RS15440	COG1140	nitrate reductase beta subunit
C1A46_RS15445	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
C1A46_RS15450	COG2181	nitrate reductase activity
C1A46_RS15455	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C1A46_RS15480	COG0826	peptidase U32
C1A46_RS15500	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
C1A46_RS15525	COG1477	protein flavinylation
C1A46_RS15565	COG4178	(ABC) transporter
C1A46_RS15575	COG5654	RES domain protein
C1A46_RS15580	COG1069	ribulokinase activity
C1A46_RS15595	COG4214	carbohydrate transport
C1A46_RS15655	COG2151	metal-sulfur cluster biosynthetic enzyme
C1A46_RS15680	COG0714	Associated with various cellular activities
C1A46_RS15685	COG3256	nitric oxide reductase
C1A46_RS15700	COG1845	cytochrome c oxidase, subunit III
C1A46_RS15715	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
C1A46_RS15720	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
C1A46_RS15750	COG0579	oxidoreductase
C1A46_RS15755	COG2176	DNA-directed DNA polymerase activity
C1A46_RS15760	COG0154	amidase activity
C1A46_RS15765	COG0154	amidase activity
C1A46_RS15770	COG0154	amidase activity
C1A46_RS15775	COG4608	Belongs to the ABC transporter superfamily
C1A46_RS15780	COG0444	Belongs to the ABC transporter superfamily
C1A46_RS15785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1A46_RS15795	COG0747	negative chemotaxis
C1A46_RS15805	COG1012	belongs to the aldehyde dehydrogenase family
C1A46_RS15810	COG1802	Transcriptional regulator
C1A46_RS15815	COG2814	Major facilitator Superfamily
C1A46_RS15860	COG0218	Necessary for normal cell division and for the maintenance of normal septation
C1A46_RS15910	COG0242	peptide deformylase activity
C1A46_RS15925	COG2827	Endonuclease containing a URI domain
C1A46_RS15960	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
C1A46_RS15985	COG1132	(ABC) transporter
C1A46_RS16015	COG0778	Nitroreductase
C1A46_RS16040	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
C1A46_RS16055	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
C1A46_RS16060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
C1A46_RS16065	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
C1A46_RS16120	COG1804	L-carnitine dehydratase bile acid-inducible protein F
C1A46_RS16125	COG4608	Belongs to the ABC transporter superfamily
C1A46_RS16130	COG0444	Belongs to the ABC transporter superfamily
C1A46_RS16135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1A46_RS16135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
C1A46_RS16140	COG0601	transmembrane transport
C1A46_RS16160	COG0022	dehydrogenase e1 component
C1A46_RS16160	COG0508	dehydrogenase complex catalyzes the overall conversion of
C1A46_RS16170	COG1250	3-hydroxyacyl-CoA dehydrogenase
C1A46_RS16180	COG1960	acyl-CoA dehydrogenase activity
C1A46_RS16225	COG0747	negative chemotaxis
C1A46_RS16230	COG0601	transmembrane transport
C1A46_RS16240	COG0444	Belongs to the ABC transporter superfamily
C1A46_RS16245	COG4608	Belongs to the ABC transporter superfamily
C1A46_RS16250	COG3386	PFAM SMP-30 Gluconolaconase
C1A46_RS16255	COG0154	amidase activity
C1A46_RS16270	COG1176	ABC-type spermidine putrescine transport system, permease component I
C1A46_RS16290	COG0235	Class ii aldolase
C1A46_RS16300	COG3395	kinase activity
C1A46_RS16310	COG2337	Toxic component of a toxin-antitoxin (TA) module
C1A46_RS16320	COG0277	FAD linked oxidase domain protein
C1A46_RS16370	COG2971	BadF BadG BcrA BcrD
C1A46_RS16375	COG1959	2 iron, 2 sulfur cluster binding
C1A46_RS16380	COG0523	cobalamin synthesis protein
C1A46_RS16395	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C1A46_RS16400	COG0735	belongs to the Fur family
C1A46_RS16435	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1A46_RS16440	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1A46_RS16445	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C1A46_RS16460	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C1A46_RS16510	COG1360	Flagellar Motor Protein
C1A46_RS16525	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
C1A46_RS16540	COG4213	ABC transporter substrate-binding protein
C1A46_RS16550	COG4214	carbohydrate transport
C1A46_RS16570	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
C1A46_RS16580	COG3971	2-oxopent-4-enoate hydratase activity
C1A46_RS16585	COG0179	Fumarylacetoacetate (FAA) hydrolase
C1A46_RS16605	COG1846	Transcriptional regulator
C1A46_RS16610	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
C1A46_RS16630	COG5441	Belongs to the UPF0261 family
C1A46_RS16640	COG0531	amino acid
C1A46_RS16645	COG1012	belongs to the aldehyde dehydrogenase family
C1A46_RS16650	COG1228	amidohydrolase
C1A46_RS16665	COG1129	ABC transporter
C1A46_RS16685	COG2188	Transcriptional regulator
C1A46_RS16690	COG1653	transport
C1A46_RS16700	COG1175	transmembrane transport
C1A46_RS16705	COG3842	ATPase activity
C1A46_RS16785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C1A46_RS16795	COG1192	Involved in chromosome partitioning