locus-tag	class	description
BFL29_RS00025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BFL29_RS00030	COG4172	Belongs to the ABC transporter superfamily
BFL29_RS00035	COG4239	(ABC) transporter, permease
BFL29_RS00040	COG4174	ABC transporter (Permease)
BFL29_RS00050	COG4166	transmembrane transport
BFL29_RS00070	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BFL29_RS00085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BFL29_RS00090	COG1960	acyl-CoA dehydrogenase activity
BFL29_RS00095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BFL29_RS00130	COG0539	negative regulation of cytoplasmic translation
BFL29_RS00140	COG0583	DNA-binding transcription factor activity
BFL29_RS00145	COG2951	lytic endotransglycosylase activity
BFL29_RS00160	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BFL29_RS00175	COG2816	NAD+ diphosphatase activity
BFL29_RS00180	COG0077	Prephenate dehydratase
BFL29_RS00180	COG1605	Chorismate mutase
BFL29_RS00190	COG3474	cytochrome
BFL29_RS00200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BFL29_RS00205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BFL29_RS00210	COG1845	cytochrome c oxidase, subunit III
BFL29_RS00215	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BFL29_RS00235	COG1376	ErfK ybiS ycfS ynhG family protein
BFL29_RS00260	COG0346	lactoylglutathione lyase activity
BFL29_RS00265	COG0489	protein tyrosine kinase activity
BFL29_RS00270	COG0033	Phosphoglucomutase
BFL29_RS00280	COG1073	alpha beta
BFL29_RS00285	COG1072	(Pantothenic acid kinase))
BFL29_RS00315	COG1272	protein, Hemolysin III
BFL29_RS00380	COG3339	Conserved Protein
BFL29_RS00395	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BFL29_RS00405	COG4181	ATPase activity
BFL29_RS00415	COG0670	Belongs to the BI1 family
BFL29_RS00435	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BFL29_RS00445	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BFL29_RS00450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BFL29_RS00460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BFL29_RS00500	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BFL29_RS00510	COG4208	sulfate ABC transporter
BFL29_RS00515	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BFL29_RS00520	COG3459	Glycosyltransferase 36 associated
BFL29_RS00530	COG0384	phenazine biosynthesis protein PhzF
BFL29_RS00535	COG2226	methyltransferase
BFL29_RS00545	COG1028	Short-chain dehydrogenase reductase Sdr
BFL29_RS00550	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BFL29_RS00565	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BFL29_RS00570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BFL29_RS00575	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BFL29_RS00575	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BFL29_RS00590	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
BFL29_RS00600	COG2153	protein acetylation
BFL29_RS00615	COG1643	Atp-dependent helicase
BFL29_RS00620	COG1643	Atp-dependent helicase
BFL29_RS00630	COG3293	Transposase
BFL29_RS00640	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BFL29_RS00650	COG1388	LysM domain
BFL29_RS00650	COG1376	ErfK ybiS ycfS ynhG family protein
BFL29_RS00655	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BFL29_RS00665	COG0180	Tryptophanyl-tRNA synthetase
BFL29_RS00670	COG0728	peptidoglycan biosynthetic process
BFL29_RS00680	COG0281	malic enzyme
BFL29_RS00680	COG0280	phosphate acetyltransferase
BFL29_RS00700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BFL29_RS00705	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
BFL29_RS00705	COG0116	Belongs to the methyltransferase superfamily
BFL29_RS00720	COG0616	signal peptide processing
BFL29_RS00730	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BFL29_RS00735	COG1137	ATPase activity
BFL29_RS00740	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BFL29_RS00745	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BFL29_RS00750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL29_RS00760	COG0071	Belongs to the small heat shock protein (HSP20) family
BFL29_RS00780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFL29_RS00810	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BFL29_RS00815	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BFL29_RS00820	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BFL29_RS00830	COG1648	precorrin-2 dehydrogenase activity
BFL29_RS00830	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BFL29_RS00840	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BFL29_RS00845	COG0175	sulfate reduction
BFL29_RS00860	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BFL29_RS00880	COG2197	response regulator
BFL29_RS00885	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BFL29_RS00900	COG1218	3'(2'),5'-bisphosphate nucleotidase
BFL29_RS00915	COG2197	response regulator
BFL29_RS00940	COG1012	belongs to the aldehyde dehydrogenase family
BFL29_RS00970	COG1012	belongs to the aldehyde dehydrogenase family
BFL29_RS00975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BFL29_RS00980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BFL29_RS00985	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BFL29_RS01010	COG0351	phosphomethylpyrimidine kinase
BFL29_RS01015	COG5001	Diguanylate cyclase
BFL29_RS01030	COG1174	glycine betaine transport
BFL29_RS01035	COG1125	glycine betaine transport
BFL29_RS01040	COG1174	glycine betaine transport
BFL29_RS01045	COG1732	Glycine betaine
BFL29_RS01055	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BFL29_RS01070	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BFL29_RS01070	COG0446	pyridine nucleotide-disulphide oxidoreductase
BFL29_RS01085	COG1414	Transcriptional regulator
BFL29_RS01095	COG1175	transmembrane transport
BFL29_RS01100	COG0395	ABC-type sugar transport system, permease component
BFL29_RS01105	COG3842	ATPase activity
BFL29_RS01110	COG4948	Mandelate Racemase Muconate Lactonizing
BFL29_RS01115	COG3254	rhamnose metabolic process
BFL29_RS01130	COG1028	Short-chain dehydrogenase reductase Sdr
BFL29_RS01140	COG4948	Mandelate Racemase Muconate Lactonizing
BFL29_RS01165	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BFL29_RS01180	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BFL29_RS01220	COG3617	BRO family, N-terminal domain
BFL29_RS01225	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BFL29_RS01295	COG4191	Histidine kinase
BFL29_RS01300	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BFL29_RS01305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BFL29_RS01320	COG1309	transcriptional regulator
BFL29_RS01325	COG0494	nUDIX hydrolase
BFL29_RS01335	COG0493	'glutamate synthase
BFL29_RS01365	COG0318	PFAM AMP-dependent synthetase and ligase
BFL29_RS01400	COG2326	polyphosphate kinase activity
BFL29_RS01405	COG5002	protein histidine kinase activity
BFL29_RS01415	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BFL29_RS01425	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BFL29_RS01440	COG0717	Belongs to the dCTP deaminase family
BFL29_RS01460	COG0534	Mate efflux family protein
BFL29_RS01490	COG2198	Histidine kinase
BFL29_RS01490	COG0784	Response regulator, receiver
BFL29_RS01490	COG2205	protein histidine kinase activity
BFL29_RS01500	COG0156	8-amino-7-oxononanoate synthase activity
BFL29_RS01525	COG0583	DNA-binding transcription factor activity
BFL29_RS01530	COG1380	Effector of murein hydrolase LrgA
BFL29_RS01535	COG1346	cytolysis
BFL29_RS01560	COG0019	diaminopimelate decarboxylase activity
BFL29_RS01600	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BFL29_RS01605	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BFL29_RS01610	COG3257	ureidoglycine aminohydrolase activity
BFL29_RS01615	COG3195	allantoin biosynthetic process
BFL29_RS01615	COG3648	Uricase
BFL29_RS01625	COG2080	2 iron, 2 sulfur cluster binding
BFL29_RS01630	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BFL29_RS01640	COG0583	DNA-binding transcription factor activity
BFL29_RS01650	COG0402	S-adenosylhomocysteine deaminase activity
BFL29_RS01705	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BFL29_RS01705	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BFL29_RS01710	COG1012	belongs to the aldehyde dehydrogenase family
BFL29_RS01715	COG2169	Transcriptional regulator
BFL29_RS01715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BFL29_RS01720	COG1393	Belongs to the ArsC family
BFL29_RS01730	COG0477	Major facilitator Superfamily
BFL29_RS01740	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
BFL29_RS01760	COG0443	Heat shock 70 kDa protein
BFL29_RS01765	COG3773	Cell wall hydrolase
BFL29_RS01850	COG0142	geranyltranstransferase activity
BFL29_RS01865	COG0751	glycine-tRNA ligase activity
BFL29_RS01870	COG0009	L-threonylcarbamoyladenylate synthase
BFL29_RS01900	COG1960	acyl-CoA dehydrogenase activity
BFL29_RS01915	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BFL29_RS01930	COG0484	heat shock protein binding
BFL29_RS01935	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BFL29_RS01945	COG1278	Cold shock
BFL29_RS01975	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BFL29_RS01975	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BFL29_RS01980	COG0123	including yeast histone deacetylase and acetoin utilization protein
BFL29_RS01985	COG1722	exodeoxyribonuclease VII activity
BFL29_RS02005	COG1741	Belongs to the pirin family
BFL29_RS02015	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BFL29_RS02040	COG5265	(ABC) transporter
BFL29_RS02050	COG1183	phosphatidylcholine synthase activity
BFL29_RS02055	COG1028	Short-chain dehydrogenase reductase Sdr
BFL29_RS02060	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BFL29_RS02075	COG0305	Participates in initiation and elongation during chromosome replication
BFL29_RS02105	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BFL29_RS02120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BFL29_RS02125	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BFL29_RS02130	COG1561	YicC-like family, N-terminal region
BFL29_RS02135	COG0194	GDP metabolic process
BFL29_RS02140	COG0312	modulator of DNA gyrase
BFL29_RS02150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BFL29_RS02155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BFL29_RS02205	COG0678	peroxiredoxin activity
BFL29_RS02205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BFL29_RS02225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BFL29_RS02230	COG0612	Peptidase, M16
BFL29_RS02245	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BFL29_RS02255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BFL29_RS02275	COG1194	a g-specific adenine glycosylase
BFL29_RS02290	COG1196	nuclear chromosome segregation
BFL29_RS02305	COG0574	Belongs to the PEP-utilizing enzyme family
BFL29_RS02305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BFL29_RS02325	COG1268	BioY protein
BFL29_RS02350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BFL29_RS02380	COG2801	Transposase and inactivated derivatives
BFL29_RS02410	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BFL29_RS02415	COG3293	Transposase
BFL29_RS02430	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BFL29_RS02430	COG0662	Cupin 2, conserved barrel domain protein
BFL29_RS02435	COG2942	2-epimerase
BFL29_RS02440	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BFL29_RS02440	COG0438	transferase activity, transferring glycosyl groups
BFL29_RS02445	COG1129	ABC transporter
BFL29_RS02450	COG1172	Belongs to the binding-protein-dependent transport system permease family
BFL29_RS02455	COG1879	ABC-type sugar transport system periplasmic component
BFL29_RS02465	COG0673	inositol 2-dehydrogenase activity
BFL29_RS02475	COG1070	Carbohydrate kinase
BFL29_RS02510	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BFL29_RS02520	COG2336	PFAM SpoVT AbrB
BFL29_RS02530	COG2186	Transcriptional regulator
BFL29_RS02535	COG2807	transmembrane transport
BFL29_RS02545	COG0433	COG0433 Predicted ATPase
BFL29_RS02550	COG1376	ErfK ybiS ycfS ynhG family protein
BFL29_RS02565	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BFL29_RS02580	COG4957	zinc ion binding
BFL29_RS02590	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BFL29_RS02600	COG0154	amidase activity
BFL29_RS02605	COG2166	iron-sulfur cluster assembly
BFL29_RS02615	COG2205	protein histidine kinase activity
BFL29_RS02645	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BFL29_RS02660	COG4695	Portal protein
BFL29_RS02720	COG1388	LysM domain
BFL29_RS02720	COG0791	NLP P60 protein
BFL29_RS02760	COG4235	cytochrome complex assembly
BFL29_RS02770	COG1138	Cytochrome C-type biogenesis protein
BFL29_RS02775	COG3088	subunit of a heme lyase
BFL29_RS02805	COG2202	Pas domain
BFL29_RS02805	COG2205	protein histidine kinase activity
BFL29_RS02810	COG0308	aminopeptidase N
BFL29_RS02825	COG1573	uracil-dna glycosylase
BFL29_RS02840	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BFL29_RS02855	COG0625	glutathione transferase activity
BFL29_RS02890	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BFL29_RS02895	COG4974	Belongs to the 'phage' integrase family
BFL29_RS02925	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BFL29_RS02925	COG3743	rRNA binding
BFL29_RS02930	COG0741	lytic transglycosylase activity
BFL29_RS02970	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BFL29_RS02975	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BFL29_RS02985	COG2223	nitrite transmembrane transporter activity
BFL29_RS02990	COG2207	Transcriptional regulator
BFL29_RS03005	COG0681	Belongs to the peptidase S26 family
BFL29_RS03030	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BFL29_RS03040	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BFL29_RS03060	COG0494	nUDIX hydrolase
BFL29_RS03085	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BFL29_RS03095	COG0739	heme binding
BFL29_RS03105	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BFL29_RS03110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BFL29_RS03115	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BFL29_RS03145	COG0488	(ABC) transporter
BFL29_RS03165	COG0314	molybdopterin synthase activity
BFL29_RS03170	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BFL29_RS03175	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BFL29_RS03210	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BFL29_RS03220	COG0243	molybdopterin cofactor binding
BFL29_RS03230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BFL29_RS03240	COG0628	permease
BFL29_RS03260	COG1028	Short-chain dehydrogenase reductase Sdr
BFL29_RS03270	COG1620	l-lactate permease
BFL29_RS03375	COG0626	cystathionine gamma-synthase activity
BFL29_RS03385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFL29_RS03390	COG4597	amino acid ABC transporter
BFL29_RS03395	COG0765	amino acid transport
BFL29_RS03400	COG1126	abc transporter atp-binding protein
BFL29_RS03425	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BFL29_RS03440	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BFL29_RS03455	COG0113	porphobilinogen synthase activity
BFL29_RS03475	COG2989	Protein conserved in bacteria
BFL29_RS03490	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BFL29_RS03490	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BFL29_RS03510	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BFL29_RS03515	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BFL29_RS03595	COG0010	Belongs to the arginase family
BFL29_RS03660	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BFL29_RS03680	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BFL29_RS03685	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BFL29_RS03725	COG1007	ATP synthesis coupled electron transport
BFL29_RS03740	COG0346	lactoylglutathione lyase activity
BFL29_RS03795	COG0483	inositol monophosphate 1-phosphatase activity
BFL29_RS03800	COG2814	Major facilitator Superfamily
BFL29_RS03835	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BFL29_RS03860	COG2514	catechol 2,3-dioxygenase activity
BFL29_RS03865	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BFL29_RS03885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BFL29_RS03890	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BFL29_RS03895	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BFL29_RS03910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BFL29_RS03915	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
BFL29_RS03920	COG3454	Phosphonate metabolism
BFL29_RS03925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BFL29_RS03935	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BFL29_RS03960	COG1522	sequence-specific DNA binding
BFL29_RS03965	COG1573	uracil-dna glycosylase
BFL29_RS03990	COG0316	Belongs to the HesB IscA family
BFL29_RS04010	COG1472	Belongs to the glycosyl hydrolase 3 family
BFL29_RS04015	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BFL29_RS04020	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BFL29_RS04030	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BFL29_RS04035	COG0805	protein transport
BFL29_RS04050	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BFL29_RS04070	COG1862	Preprotein translocase
BFL29_RS04115	COG0544	peptidyl-prolyl cis-trans isomerase activity
BFL29_RS04135	COG4765	Protein conserved in bacteria
BFL29_RS04145	COG0439	Biotin carboxylase
BFL29_RS04150	COG0511	ligase activity, forming carbon-carbon bonds
BFL29_RS04165	COG0501	Belongs to the peptidase M48B family
BFL29_RS04175	COG0436	Aminotransferase
BFL29_RS04180	COG1530	ribonuclease E activity
BFL29_RS04190	COG0860	N-Acetylmuramoyl-L-alanine amidase
BFL29_RS04195	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BFL29_RS04205	COG3293	Transposase
BFL29_RS04220	COG2833	Protein of unknown function (DUF455)
BFL29_RS04225	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BFL29_RS04250	COG2945	thiolester hydrolase activity
BFL29_RS04260	COG0719	Fe-S assembly protein
BFL29_RS04265	COG0396	ATPase activity
BFL29_RS04270	COG0719	Fe-S assembly protein
BFL29_RS04275	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BFL29_RS04280	COG2151	metal-sulfur cluster biosynthetic enzyme
BFL29_RS04300	COG0513	Belongs to the DEAD box helicase family
BFL29_RS04305	COG0316	Belongs to the HesB IscA family
BFL29_RS04320	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BFL29_RS04350	COG2084	Dehydrogenase
BFL29_RS04355	COG0625	glutathione transferase activity
BFL29_RS04405	COG2989	Protein conserved in bacteria
BFL29_RS04500	COG3293	Transposase
BFL29_RS04540	COG1393	Belongs to the ArsC family
BFL29_RS04570	COG0084	hydrolase, TatD family'
BFL29_RS04605	COG0174	glutamine synthetase
BFL29_RS04610	COG0347	Belongs to the P(II) protein family
BFL29_RS04615	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BFL29_RS04615	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BFL29_RS04625	COG0546	phosphoglycolate phosphatase activity
BFL29_RS04645	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BFL29_RS04650	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BFL29_RS04670	COG0280	phosphate acetyltransferase
BFL29_RS04670	COG0281	malic enzyme
BFL29_RS04675	COG4948	Mandelate Racemase Muconate Lactonizing
BFL29_RS04680	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BFL29_RS04685	COG1127	ABC transporter
BFL29_RS04705	COG0633	Ferredoxin
BFL29_RS04720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BFL29_RS04730	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BFL29_RS04745	COG3106	COG3106 Predicted ATPase
BFL29_RS04770	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
BFL29_RS04785	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BFL29_RS04805	COG1546	Belongs to the CinA family
BFL29_RS04805	COG1058	Belongs to the CinA family
BFL29_RS04820	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BFL29_RS04825	COG0513	Belongs to the DEAD box helicase family
BFL29_RS04830	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BFL29_RS04835	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BFL29_RS04840	COG2897	thiosulfate sulfurtransferase activity
BFL29_RS04855	COG0427	acetyl-CoA hydrolase
BFL29_RS04860	COG2814	Major facilitator Superfamily
BFL29_RS04865	COG1566	PFAM secretion protein HlyD family protein
BFL29_RS04875	COG0006	proline dipeptidase activity
BFL29_RS04880	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BFL29_RS04890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BFL29_RS04895	COG3956	TIGRFAM MazG family protein
BFL29_RS04900	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BFL29_RS04920	COG1686	Belongs to the peptidase S11 family
BFL29_RS04945	COG1752	Esterase of the alpha-beta hydrolase superfamily
BFL29_RS04980	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BFL29_RS05000	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BFL29_RS05005	COG1960	acyl-CoA dehydrogenase activity
BFL29_RS05010	COG0583	DNA-binding transcription factor activity
BFL29_RS05015	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BFL29_RS05020	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BFL29_RS05025	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BFL29_RS05065	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BFL29_RS05070	COG2095	MarC family integral membrane protein
BFL29_RS05080	COG2188	Transcriptional regulator
BFL29_RS05115	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BFL29_RS05130	COG0569	domain protein
BFL29_RS05135	COG2204	response regulator
BFL29_RS05140	COG5000	phosphorelay sensor kinase activity
BFL29_RS05145	COG2204	response regulator
BFL29_RS05150	COG3852	Histidine kinase
BFL29_RS05165	COG1546	Belongs to the CinA family
BFL29_RS05165	COG1058	Belongs to the CinA family
BFL29_RS05170	COG1028	Short-chain dehydrogenase reductase Sdr
BFL29_RS05175	COG2867	negative regulation of translational initiation
BFL29_RS05190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BFL29_RS05195	COG0508	dehydrogenase complex catalyzes the overall conversion of
BFL29_RS05200	COG0022	dehydrogenase e1 component
BFL29_RS05200	COG0508	dehydrogenase complex catalyzes the overall conversion of
BFL29_RS05205	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BFL29_RS05210	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BFL29_RS05250	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BFL29_RS05270	COG0303	'Molybdopterin
BFL29_RS05290	COG0372	Belongs to the citrate synthase family
BFL29_RS05295	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BFL29_RS05320	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BFL29_RS05375	COG0584	glycerophosphoryl diester phosphodiesterase
BFL29_RS05385	COG0537	adenosine 5'-monophosphoramidase activity
BFL29_RS05400	COG1686	Belongs to the peptidase S11 family
BFL29_RS05415	COG1760	l-serine dehydratase
BFL29_RS05465	COG1396	sequence-specific DNA binding
BFL29_RS05465	COG3800	Transcriptional regulator
BFL29_RS05470	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BFL29_RS05475	COG4770	biotin carboxylase activity
BFL29_RS05480	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFL29_RS05480	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BFL29_RS05495	COG2358	TRAP transporter, solute receptor (TAXI family
BFL29_RS05505	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BFL29_RS05510	COG0693	protein deglycase activity
BFL29_RS05520	COG0538	isocitrate dehydrogenase activity
BFL29_RS05525	COG1785	Belongs to the alkaline phosphatase family
BFL29_RS05540	COG2885	chlorophyll binding
BFL29_RS05550	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BFL29_RS05555	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BFL29_RS05600	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BFL29_RS05665	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BFL29_RS05755	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BFL29_RS05780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BFL29_RS05835	COG0346	lactoylglutathione lyase activity
BFL29_RS05855	COG1494	fructose-1,6-bisphosphatase
BFL29_RS05865	COG0436	Aminotransferase
BFL29_RS05900	COG0024	Methionine aminopeptidase
BFL29_RS05950	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BFL29_RS06105	COG4651	solute:proton antiporter activity
BFL29_RS06105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BFL29_RS06120	COG4208	sulfate ABC transporter
BFL29_RS06125	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BFL29_RS06130	COG4150	thiosulfate binding
BFL29_RS06140	COG1253	flavin adenine dinucleotide binding
BFL29_RS06165	COG4154	Belongs to the RbsD FucU family
BFL29_RS06170	COG1028	Short-chain dehydrogenase reductase Sdr
BFL29_RS06180	COG1172	Belongs to the binding-protein-dependent transport system permease family
BFL29_RS06195	COG1120	ATPase activity
BFL29_RS06200	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BFL29_RS06215	COG0842	Transport permease protein
BFL29_RS06220	COG0842	Transport permease protein
BFL29_RS06220	COG1129	ABC transporter
BFL29_RS06225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BFL29_RS06230	COG1649	PFAM Uncharacterised BCR, COG1649
BFL29_RS06270	COG4413	Urea transporter
BFL29_RS06280	COG0310	cobalt ion transport
BFL29_RS06320	COG0384	phenazine biosynthesis protein PhzF
BFL29_RS06340	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BFL29_RS06375	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BFL29_RS06380	COG0440	acetolactate synthase activity
BFL29_RS06385	COG0028	Belongs to the TPP enzyme family
BFL29_RS06395	COG0560	Phosphoserine phosphatase
BFL29_RS06400	COG2081	HI0933 family
BFL29_RS06415	COG0330	HflC and HflK could
BFL29_RS06445	COG2814	Major facilitator Superfamily
BFL29_RS06485	COG0277	FAD linked oxidase domain protein
BFL29_RS06500	COG0210	DNA helicase
BFL29_RS06515	COG1999	signal sequence binding
BFL29_RS06525	COG0006	proline dipeptidase activity
BFL29_RS06545	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BFL29_RS06555	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BFL29_RS06560	COG0849	cell division
BFL29_RS06565	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BFL29_RS06630	COG1914	H( )-stimulated, divalent metal cation uptake system
BFL29_RS06645	COG3023	N-Acetylmuramoyl-L-alanine amidase
BFL29_RS06650	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BFL29_RS06680	COG0640	Transcriptional regulator
BFL29_RS06690	COG0477	Major facilitator Superfamily
BFL29_RS06710	COG2267	carboxylic ester hydrolase activity
BFL29_RS06735	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BFL29_RS06740	COG2824	Alkylphosphonate utilization operon protein PhnA
BFL29_RS06745	COG1335	isochorismatase
BFL29_RS06760	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BFL29_RS06800	COG2968	Membrane
BFL29_RS06820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BFL29_RS06825	COG0358	DNA primase activity
BFL29_RS06845	COG2321	neutral zinc metallopeptidase
BFL29_RS06865	COG1136	(ABC) transporter
BFL29_RS06875	COG1278	Cold shock
BFL29_RS06880	COG0625	glutathione transferase activity
BFL29_RS06885	COG0436	Aminotransferase
BFL29_RS06900	COG0583	DNA-binding transcription factor activity
BFL29_RS06905	COG0492	ferredoxin-NADP+ reductase activity
BFL29_RS06910	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BFL29_RS06915	COG1522	sequence-specific DNA binding
BFL29_RS06960	COG0556	nucleotide-excision repair
BFL29_RS06965	COG1196	nuclear chromosome segregation
BFL29_RS06965	COG0741	lytic transglycosylase activity
BFL29_RS06965	COG0739	heme binding
BFL29_RS06970	COG1278	Cold shock
BFL29_RS06980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BFL29_RS07000	COG0745	RESPONSE REGULATOR receiver
BFL29_RS07005	COG2205	protein histidine kinase activity
BFL29_RS07015	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BFL29_RS07040	COG1496	oxidoreductase activity
BFL29_RS07060	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BFL29_RS07085	COG0012	GTP binding
BFL29_RS07090	COG2030	dehydratase
BFL29_RS07105	COG2857	Cytochrome c1
BFL29_RS07105	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BFL29_RS07120	COG1132	(ABC) transporter
BFL29_RS07125	COG1132	(ABC) transporter
BFL29_RS07130	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BFL29_RS07150	COG3153	acetyltransferase
BFL29_RS07165	COG0617	tRNA 3'-terminal CCA addition
BFL29_RS07180	COG0714	Associated with various cellular activities
BFL29_RS07205	COG0435	Glutathione S-transferase
BFL29_RS07210	COG3047	cAMP biosynthetic process
BFL29_RS07215	COG1051	belongs to the nudix hydrolase family
BFL29_RS07230	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BFL29_RS07235	COG0512	Glutamine amidotransferase of anthranilate synthase
BFL29_RS07235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BFL29_RS07245	COG1522	sequence-specific DNA binding
BFL29_RS07275	COG4176	ABC-type proline glycine betaine transport system permease component
BFL29_RS07280	COG3448	diguanylate cyclase activity
BFL29_RS07280	COG4175	Glycine betaine
BFL29_RS07285	COG4608	Belongs to the ABC transporter superfamily
BFL29_RS07290	COG0444	Belongs to the ABC transporter superfamily
BFL29_RS07295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BFL29_RS07300	COG0601	transmembrane transport
BFL29_RS07305	COG0747	negative chemotaxis
BFL29_RS07310	COG0747	negative chemotaxis
BFL29_RS07315	COG0747	negative chemotaxis
BFL29_RS07415	COG1177	transmembrane transport
BFL29_RS07420	COG1176	ABC-type spermidine putrescine transport system, permease component I
BFL29_RS07425	COG3842	ATPase activity
BFL29_RS07440	COG2224	Isocitrate lyase
BFL29_RS07460	COG1028	Short-chain dehydrogenase reductase Sdr
BFL29_RS07465	COG1028	Short-chain dehydrogenase reductase Sdr
BFL29_RS07480	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BFL29_RS07485	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BFL29_RS07500	COG1461	Dihydroxyacetone kinase
BFL29_RS07505	COG2376	Dihydroxyacetone kinase
BFL29_RS07510	COG1461	Dihydroxyacetone kinase
BFL29_RS07515	COG2376	Dihydroxyacetone kinase
BFL29_RS07520	COG1028	Short-chain dehydrogenase reductase Sdr
BFL29_RS07525	COG1879	ABC-type sugar transport system periplasmic component
BFL29_RS07530	COG1172	Belongs to the binding-protein-dependent transport system permease family
BFL29_RS07535	COG1129	ABC transporter
BFL29_RS07545	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BFL29_RS07595	COG1012	belongs to the aldehyde dehydrogenase family
BFL29_RS07620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BFL29_RS07635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BFL29_RS07640	COG0564	pseudouridine synthase activity
BFL29_RS07660	COG2202	Pas domain
BFL29_RS07660	COG3920	Histidine kinase
BFL29_RS07670	COG0784	Response regulator, receiver
BFL29_RS07685	COG3920	Histidine kinase
BFL29_RS07720	COG0848	biopolymer transport protein
BFL29_RS07735	COG1136	(ABC) transporter
BFL29_RS07735	COG4591	ABC-type transport system involved in lipoprotein release permease component
BFL29_RS07740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BFL29_RS07750	COG1522	sequence-specific DNA binding
BFL29_RS07770	COG0477	Major facilitator Superfamily
BFL29_RS07790	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BFL29_RS07815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BFL29_RS07835	COG2885	chlorophyll binding
BFL29_RS07850	COG0848	biopolymer transport protein
BFL29_RS07905	COG0483	inositol monophosphate 1-phosphatase activity
BFL29_RS07920	COG1132	(ABC) transporter
BFL29_RS07950	COG1253	flavin adenine dinucleotide binding
BFL29_RS07955	COG1692	metallophosphoesterase
BFL29_RS08025	COG0604	alcohol dehydrogenase
BFL29_RS08025	COG3321	synthase
BFL29_RS08025	COG1028	Short-chain dehydrogenase reductase Sdr
BFL29_RS08055	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BFL29_RS08065	COG0457	Tetratricopeptide repeat
BFL29_RS08070	COG0469	pyruvate kinase activity
BFL29_RS08090	COG0488	(ABC) transporter
BFL29_RS08125	COG2258	MOSC domain
BFL29_RS08130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BFL29_RS08135	COG1329	Transcriptional regulator
BFL29_RS08140	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BFL29_RS08155	COG0183	Belongs to the thiolase family
BFL29_RS08175	COG0142	geranyltranstransferase activity
BFL29_RS08185	COG1028	Short-chain dehydrogenase reductase Sdr
BFL29_RS08190	COG0738	Major facilitator superfamily
BFL29_RS08195	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BFL29_RS08230	COG0559	Belongs to the binding-protein-dependent transport system permease family
BFL29_RS08240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BFL29_RS08305	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BFL29_RS08315	COG5425	PFAM Usg family protein
BFL29_RS08335	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BFL29_RS08335	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BFL29_RS08350	COG2270	Major facilitator Superfamily
BFL29_RS08365	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BFL29_RS08370	COG1704	LemA family
BFL29_RS08380	COG1605	Chorismate mutase
BFL29_RS08380	COG0287	Prephenate dehydrogenase
BFL29_RS08385	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BFL29_RS08395	COG0288	reversible hydration of carbon dioxide
BFL29_RS08415	COG0583	DNA-binding transcription factor activity
BFL29_RS08435	COG0793	Belongs to the peptidase S41A family
BFL29_RS08455	COG0799	negative regulation of ribosome biogenesis
BFL29_RS08520	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BFL29_RS08575	COG0739	heme binding
BFL29_RS08580	COG1376	ErfK ybiS ycfS ynhG family protein
BFL29_RS08595	COG2890	protein-(glutamine-N5) methyltransferase activity
BFL29_RS08610	COG0527	aspartate kinase activity
BFL29_RS08640	COG1040	competence protein
BFL29_RS08645	COG2226	methyltransferase
BFL29_RS08700	COG2264	protein methyltransferase activity
BFL29_RS08705	COG0697	spore germination
BFL29_RS08710	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BFL29_RS08720	COG0004	ammonium transporteR
BFL29_RS08725	COG1946	Acyl-CoA thioesterase
BFL29_RS08730	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BFL29_RS08775	COG1953	Uracil, thiamine, allantoin
BFL29_RS08835	COG1280	lysine exporter protein (LysE YggA)
BFL29_RS08845	COG0508	dehydrogenase complex catalyzes the overall conversion of
BFL29_RS08855	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BFL29_RS08870	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BFL29_RS08885	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BFL29_RS08890	COG0552	protein localization to endoplasmic reticulum
BFL29_RS08915	COG0494	nUDIX hydrolase
BFL29_RS08930	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BFL29_RS08955	COG2194	sulfuric ester hydrolase activity
BFL29_RS08980	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFL29_RS08985	COG0765	amino acid transport
BFL29_RS08990	COG0765	amino acid transport
BFL29_RS09010	COG1126	abc transporter atp-binding protein
BFL29_RS09020	COG1802	Transcriptional regulator
BFL29_RS09025	COG0252	asparaginase activity
BFL29_RS09050	COG1250	3-hydroxyacyl-CoA dehydrogenase
BFL29_RS09055	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BFL29_RS09060	COG2086	electron transfer activity
BFL29_RS09070	COG0720	synthase
BFL29_RS09075	COG0602	queuosine metabolic process
BFL29_RS09090	COG0300	oxidoreductase activity
BFL29_RS09105	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BFL29_RS09135	COG2226	methyltransferase
BFL29_RS09145	COG0287	Prephenate dehydrogenase
BFL29_RS09170	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BFL29_RS09190	COG2884	Cell division ATP-binding protein ftsE
BFL29_RS09205	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BFL29_RS09250	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BFL29_RS09265	COG0789	Transcriptional regulator
BFL29_RS09270	COG2217	Heavy metal translocating P-type atpase
BFL29_RS09305	COG4536	flavin adenine dinucleotide binding
BFL29_RS09345	COG0523	cobalamin synthesis protein
BFL29_RS09350	COG1686	Belongs to the peptidase S11 family
BFL29_RS09355	COG1473	amidohydrolase
BFL29_RS09365	COG1028	Short-chain dehydrogenase reductase Sdr
BFL29_RS09385	COG1028	Short-chain dehydrogenase reductase Sdr
BFL29_RS09395	COG1012	belongs to the aldehyde dehydrogenase family
BFL29_RS09400	COG1024	Enoyl-CoA hydratase
BFL29_RS09430	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BFL29_RS09440	COG4120	Belongs to the binding-protein-dependent transport system permease family
BFL29_RS09445	COG1122	ATPase activity
BFL29_RS09480	COG1331	Highly conserved protein containing a thioredoxin domain
BFL29_RS09485	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BFL29_RS09495	COG1981	membrane
BFL29_RS09520	COG0237	dephospho-CoA kinase activity
BFL29_RS09540	COG4395	Tim44
BFL29_RS09550	COG2840	Smr protein MutS2
BFL29_RS09555	COG1396	sequence-specific DNA binding
BFL29_RS09620	COG0745	RESPONSE REGULATOR receiver
BFL29_RS09625	COG2205	protein histidine kinase activity
BFL29_RS09635	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BFL29_RS09635	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL29_RS09640	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BFL29_RS09650	COG2205	protein histidine kinase activity
BFL29_RS09655	COG3178	'Phosphotransferase
BFL29_RS09660	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BFL29_RS09665	COG2887	Belongs to the helicase family. UvrD subfamily
BFL29_RS09670	COG1074	ATP-dependent DNA helicase activity
BFL29_RS09680	COG0285	dihydrofolate synthase activity
BFL29_RS09710	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BFL29_RS09725	COG3135	benzoate transporter
BFL29_RS09740	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BFL29_RS09790	COG3963	phosphatidate phosphatase activity
BFL29_RS09805	COG3386	PFAM SMP-30 Gluconolaconase
BFL29_RS09815	COG0606	chelatase, subunit chli
BFL29_RS09825	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BFL29_RS09830	COG2832	Protein of unknown function (DUF454)
BFL29_RS09835	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BFL29_RS09840	COG0573	inorganic phosphate transmembrane transporter activity
BFL29_RS09850	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BFL29_RS09855	COG0704	Plays a role in the regulation of phosphate uptake
BFL29_RS09860	COG0745	RESPONSE REGULATOR receiver
BFL29_RS09865	COG3773	Cell wall hydrolase
BFL29_RS09875	COG2309	aminopeptidase activity
BFL29_RS09880	COG0783	Belongs to the Dps family
BFL29_RS09890	COG0456	acetyltransferase
BFL29_RS09915	COG4535	Mg2 and Co2 transporter CorC
BFL29_RS09925	COG1396	sequence-specific DNA binding
BFL29_RS09930	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BFL29_RS09945	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BFL29_RS09945	COG0195	Participates in both transcription termination and antitermination
BFL29_RS09980	COG2813	Specifically methylates the guanine in position
BFL29_RS09985	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BFL29_RS10025	COG0791	NLP P60 protein
BFL29_RS10035	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BFL29_RS10050	COG1024	Enoyl-CoA hydratase
BFL29_RS10380	COG0033	Phosphoglucomutase
BFL29_RS10610	COG3459	Glycosyltransferase 36 associated
BFL29_RS10615	COG3459	Glycosyltransferase 36 associated
BFL29_RS10680	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BFL29_RS10790	COG1643	Atp-dependent helicase
BFL29_RS11005	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BFL29_RS11035	COG0646	methionine synthase
BFL29_RS11035	COG1410	methionine synthase
BFL29_RS11105	COG1012	belongs to the aldehyde dehydrogenase family
BFL29_RS11200	COG2217	Heavy metal translocating P-type atpase
BFL29_RS11565	COG5002	protein histidine kinase activity
BFL29_RS11765	COG3648	Uricase
BFL29_RS11765	COG3195	allantoin biosynthetic process
BFL29_RS12575	COG1129	ABC transporter
BFL29_RS13445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BFL29_RS14600	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BFL29_RS14875	COG0477	Major facilitator Superfamily
BFL29_RS14965	COG1752	Esterase of the alpha-beta hydrolase superfamily
BFL29_RS15015	COG0583	DNA-binding transcription factor activity
BFL29_RS15025	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BFL29_RS15585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain