locus-tag	class	description
DA85_RS00025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DA85_RS00030	COG4172	Belongs to the ABC transporter superfamily
DA85_RS00035	COG4239	(ABC) transporter, permease
DA85_RS00040	COG4174	ABC transporter (Permease)
DA85_RS00050	COG4166	transmembrane transport
DA85_RS00070	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
DA85_RS00085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DA85_RS00090	COG1960	acyl-CoA dehydrogenase activity
DA85_RS00095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DA85_RS00130	COG0539	negative regulation of cytoplasmic translation
DA85_RS00140	COG0583	DNA-binding transcription factor activity
DA85_RS00150	COG2951	lytic endotransglycosylase activity
DA85_RS00165	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DA85_RS00175	COG2816	NAD+ diphosphatase activity
DA85_RS00180	COG0077	Prephenate dehydratase
DA85_RS00180	COG1605	Chorismate mutase
DA85_RS00190	COG3474	cytochrome
DA85_RS00200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DA85_RS00205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DA85_RS00210	COG1845	cytochrome c oxidase, subunit III
DA85_RS00215	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
DA85_RS00235	COG1376	ErfK ybiS ycfS ynhG family protein
DA85_RS00260	COG0346	lactoylglutathione lyase activity
DA85_RS00265	COG0489	protein tyrosine kinase activity
DA85_RS00270	COG0033	Phosphoglucomutase
DA85_RS00280	COG1073	alpha beta
DA85_RS00285	COG1072	(Pantothenic acid kinase))
DA85_RS00315	COG1272	protein, Hemolysin III
DA85_RS00380	COG3339	Conserved Protein
DA85_RS00395	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
DA85_RS00405	COG4181	ATPase activity
DA85_RS00415	COG0670	Belongs to the BI1 family
DA85_RS00435	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
DA85_RS00445	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DA85_RS00450	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DA85_RS00460	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA85_RS00500	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DA85_RS00510	COG4208	sulfate ABC transporter
DA85_RS00515	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DA85_RS00520	COG3459	Glycosyltransferase 36 associated
DA85_RS00530	COG0384	phenazine biosynthesis protein PhzF
DA85_RS00535	COG2226	methyltransferase
DA85_RS00545	COG1028	Short-chain dehydrogenase reductase Sdr
DA85_RS00550	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DA85_RS00565	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DA85_RS00570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DA85_RS00575	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DA85_RS00575	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
DA85_RS00590	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DA85_RS00600	COG2153	protein acetylation
DA85_RS00615	COG1643	Atp-dependent helicase
DA85_RS00620	COG1643	Atp-dependent helicase
DA85_RS00630	COG3293	Transposase
DA85_RS00640	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DA85_RS00650	COG1388	LysM domain
DA85_RS00650	COG1376	ErfK ybiS ycfS ynhG family protein
DA85_RS00655	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
DA85_RS00665	COG0180	Tryptophanyl-tRNA synthetase
DA85_RS00670	COG0728	peptidoglycan biosynthetic process
DA85_RS00680	COG0281	malic enzyme
DA85_RS00680	COG0280	phosphate acetyltransferase
DA85_RS00705	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DA85_RS00710	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
DA85_RS00710	COG0116	Belongs to the methyltransferase superfamily
DA85_RS00725	COG0616	signal peptide processing
DA85_RS00735	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
DA85_RS00740	COG1137	ATPase activity
DA85_RS00745	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DA85_RS00750	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DA85_RS00755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA85_RS00765	COG0071	Belongs to the small heat shock protein (HSP20) family
DA85_RS00785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA85_RS00815	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DA85_RS00820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DA85_RS00825	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DA85_RS00835	COG1648	precorrin-2 dehydrogenase activity
DA85_RS00835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DA85_RS00845	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
DA85_RS00850	COG0175	sulfate reduction
DA85_RS00865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DA85_RS00885	COG2197	response regulator
DA85_RS00890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DA85_RS00905	COG1218	3'(2'),5'-bisphosphate nucleotidase
DA85_RS00920	COG2197	response regulator
DA85_RS00945	COG1012	belongs to the aldehyde dehydrogenase family
DA85_RS00975	COG1012	belongs to the aldehyde dehydrogenase family
DA85_RS00980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DA85_RS00985	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DA85_RS00990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DA85_RS01015	COG0351	phosphomethylpyrimidine kinase
DA85_RS01020	COG5001	Diguanylate cyclase
DA85_RS01035	COG1174	glycine betaine transport
DA85_RS01040	COG1125	glycine betaine transport
DA85_RS01045	COG1174	glycine betaine transport
DA85_RS01050	COG1732	Glycine betaine
DA85_RS01060	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DA85_RS01075	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DA85_RS01075	COG0446	pyridine nucleotide-disulphide oxidoreductase
DA85_RS01090	COG1414	Transcriptional regulator
DA85_RS01100	COG1175	transmembrane transport
DA85_RS01105	COG0395	ABC-type sugar transport system, permease component
DA85_RS01110	COG3842	ATPase activity
DA85_RS01115	COG4948	Mandelate Racemase Muconate Lactonizing
DA85_RS01120	COG3254	rhamnose metabolic process
DA85_RS01135	COG1028	Short-chain dehydrogenase reductase Sdr
DA85_RS01145	COG4948	Mandelate Racemase Muconate Lactonizing
DA85_RS01170	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DA85_RS01185	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DA85_RS01225	COG3617	BRO family, N-terminal domain
DA85_RS01230	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DA85_RS01300	COG4191	Histidine kinase
DA85_RS01305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA85_RS01310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DA85_RS01325	COG1309	transcriptional regulator
DA85_RS01330	COG0494	nUDIX hydrolase
DA85_RS01340	COG0493	'glutamate synthase
DA85_RS01370	COG0318	PFAM AMP-dependent synthetase and ligase
DA85_RS01405	COG2326	polyphosphate kinase activity
DA85_RS01410	COG5002	protein histidine kinase activity
DA85_RS01420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DA85_RS01430	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DA85_RS01450	COG0717	Belongs to the dCTP deaminase family
DA85_RS01470	COG0534	Mate efflux family protein
DA85_RS01500	COG2198	Histidine kinase
DA85_RS01500	COG2205	protein histidine kinase activity
DA85_RS01500	COG0784	Response regulator, receiver
DA85_RS01510	COG0156	8-amino-7-oxononanoate synthase activity
DA85_RS01535	COG0583	DNA-binding transcription factor activity
DA85_RS01540	COG1380	Effector of murein hydrolase LrgA
DA85_RS01545	COG1346	cytolysis
DA85_RS01570	COG0019	diaminopimelate decarboxylase activity
DA85_RS01610	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
DA85_RS01615	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DA85_RS01620	COG3257	ureidoglycine aminohydrolase activity
DA85_RS01625	COG3195	allantoin biosynthetic process
DA85_RS01625	COG3648	Uricase
DA85_RS01635	COG2080	2 iron, 2 sulfur cluster binding
DA85_RS01640	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DA85_RS01650	COG0583	DNA-binding transcription factor activity
DA85_RS01660	COG0402	S-adenosylhomocysteine deaminase activity
DA85_RS01715	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DA85_RS01715	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DA85_RS01720	COG1012	belongs to the aldehyde dehydrogenase family
DA85_RS01725	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DA85_RS01725	COG2169	Transcriptional regulator
DA85_RS01730	COG1393	Belongs to the ArsC family
DA85_RS01740	COG0477	Major facilitator Superfamily
DA85_RS01750	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
DA85_RS01770	COG0443	Heat shock 70 kDa protein
DA85_RS01775	COG3773	Cell wall hydrolase
DA85_RS01860	COG0142	geranyltranstransferase activity
DA85_RS01875	COG0751	glycine-tRNA ligase activity
DA85_RS01880	COG0751	glycine-tRNA ligase activity
DA85_RS01885	COG0009	L-threonylcarbamoyladenylate synthase
DA85_RS01915	COG1960	acyl-CoA dehydrogenase activity
DA85_RS01930	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
DA85_RS01945	COG0484	heat shock protein binding
DA85_RS01950	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DA85_RS01960	COG1278	Cold shock
DA85_RS01990	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DA85_RS01990	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DA85_RS01995	COG0123	including yeast histone deacetylase and acetoin utilization protein
DA85_RS02000	COG1722	exodeoxyribonuclease VII activity
DA85_RS02020	COG1741	Belongs to the pirin family
DA85_RS02030	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
DA85_RS02055	COG5265	(ABC) transporter
DA85_RS02065	COG1183	phosphatidylcholine synthase activity
DA85_RS02070	COG1028	Short-chain dehydrogenase reductase Sdr
DA85_RS02075	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DA85_RS02090	COG0305	Participates in initiation and elongation during chromosome replication
DA85_RS02095	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DA85_RS02120	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DA85_RS02135	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA85_RS02140	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DA85_RS02145	COG1561	YicC-like family, N-terminal region
DA85_RS02150	COG0194	GDP metabolic process
DA85_RS02155	COG0312	modulator of DNA gyrase
DA85_RS02165	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
DA85_RS02170	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DA85_RS02220	COG0678	peroxiredoxin activity
DA85_RS02220	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
DA85_RS02240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DA85_RS02245	COG0612	Peptidase, M16
DA85_RS02260	COG4943	cyclic-guanylate-specific phosphodiesterase activity
DA85_RS02270	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DA85_RS02290	COG1194	a g-specific adenine glycosylase
DA85_RS02305	COG1196	nuclear chromosome segregation
DA85_RS02320	COG0574	Belongs to the PEP-utilizing enzyme family
DA85_RS02320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DA85_RS02345	COG1268	BioY protein
DA85_RS02370	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DA85_RS02400	COG2801	Transposase and inactivated derivatives
DA85_RS02430	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DA85_RS02435	COG3293	Transposase
DA85_RS02445	COG3293	Transposase
DA85_RS02455	COG3293	Transposase
DA85_RS02465	COG2801	Transposase and inactivated derivatives
DA85_RS02480	COG0662	Cupin 2, conserved barrel domain protein
DA85_RS02480	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DA85_RS02485	COG2942	2-epimerase
DA85_RS02490	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DA85_RS02490	COG0438	transferase activity, transferring glycosyl groups
DA85_RS02495	COG1129	ABC transporter
DA85_RS02500	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA85_RS02505	COG1879	ABC-type sugar transport system periplasmic component
DA85_RS02515	COG0673	inositol 2-dehydrogenase activity
DA85_RS02525	COG1070	Carbohydrate kinase
DA85_RS02560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DA85_RS02570	COG2336	PFAM SpoVT AbrB
DA85_RS02580	COG2186	Transcriptional regulator
DA85_RS02585	COG2807	transmembrane transport
DA85_RS02595	COG0433	COG0433 Predicted ATPase
DA85_RS02600	COG1376	ErfK ybiS ycfS ynhG family protein
DA85_RS02610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DA85_RS02625	COG4957	zinc ion binding
DA85_RS02635	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DA85_RS02645	COG0154	amidase activity
DA85_RS02650	COG2166	iron-sulfur cluster assembly
DA85_RS02660	COG2205	protein histidine kinase activity
DA85_RS02690	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DA85_RS02705	COG4695	Portal protein
DA85_RS02805	COG4235	cytochrome complex assembly
DA85_RS02815	COG1138	Cytochrome C-type biogenesis protein
DA85_RS02820	COG3088	subunit of a heme lyase
DA85_RS02850	COG2202	Pas domain
DA85_RS02850	COG2205	protein histidine kinase activity
DA85_RS02855	COG0308	aminopeptidase N
DA85_RS02870	COG1573	uracil-dna glycosylase
DA85_RS02885	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DA85_RS02900	COG0625	glutathione transferase activity
DA85_RS02935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
DA85_RS02940	COG4974	Belongs to the 'phage' integrase family
DA85_RS02970	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DA85_RS02970	COG3743	rRNA binding
DA85_RS02975	COG0741	lytic transglycosylase activity
DA85_RS03015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
DA85_RS03020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DA85_RS03025	COG2223	nitrite transmembrane transporter activity
DA85_RS03030	COG2207	Transcriptional regulator
DA85_RS03045	COG0681	Belongs to the peptidase S26 family
DA85_RS03070	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
DA85_RS03080	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DA85_RS03100	COG0494	nUDIX hydrolase
DA85_RS03125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DA85_RS03135	COG0739	heme binding
DA85_RS03145	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DA85_RS03150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DA85_RS03155	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
DA85_RS03185	COG0488	(ABC) transporter
DA85_RS03205	COG0314	molybdopterin synthase activity
DA85_RS03210	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DA85_RS03215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DA85_RS03250	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DA85_RS03260	COG0243	molybdopterin cofactor binding
DA85_RS03270	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DA85_RS03280	COG0628	permease
DA85_RS03300	COG1028	Short-chain dehydrogenase reductase Sdr
DA85_RS03310	COG1620	l-lactate permease
DA85_RS03410	COG0626	cystathionine gamma-synthase activity
DA85_RS03425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA85_RS03430	COG4597	amino acid ABC transporter
DA85_RS03435	COG0765	amino acid transport
DA85_RS03440	COG1126	abc transporter atp-binding protein
DA85_RS03455	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DA85_RS03465	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
DA85_RS03480	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DA85_RS03495	COG0113	porphobilinogen synthase activity
DA85_RS03515	COG2989	Protein conserved in bacteria
DA85_RS03530	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DA85_RS03530	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DA85_RS03550	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
DA85_RS03555	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA85_RS03635	COG0010	Belongs to the arginase family
DA85_RS03700	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DA85_RS03720	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DA85_RS03725	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
DA85_RS03765	COG1007	ATP synthesis coupled electron transport
DA85_RS03780	COG0346	lactoylglutathione lyase activity
DA85_RS03835	COG0483	inositol monophosphate 1-phosphatase activity
DA85_RS03840	COG2814	Major facilitator Superfamily
DA85_RS03875	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DA85_RS03900	COG2514	catechol 2,3-dioxygenase activity
DA85_RS03905	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DA85_RS03925	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA85_RS03930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DA85_RS03935	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DA85_RS03950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DA85_RS03955	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
DA85_RS03960	COG3454	Phosphonate metabolism
DA85_RS03965	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DA85_RS03975	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DA85_RS04000	COG1522	sequence-specific DNA binding
DA85_RS04005	COG1573	uracil-dna glycosylase
DA85_RS04030	COG0316	Belongs to the HesB IscA family
DA85_RS04050	COG1472	Belongs to the glycosyl hydrolase 3 family
DA85_RS04055	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DA85_RS04060	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DA85_RS04070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DA85_RS04075	COG0805	protein transport
DA85_RS04090	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DA85_RS04110	COG1862	Preprotein translocase
DA85_RS04155	COG0544	peptidyl-prolyl cis-trans isomerase activity
DA85_RS04175	COG4765	Protein conserved in bacteria
DA85_RS04185	COG0439	Biotin carboxylase
DA85_RS04190	COG0511	ligase activity, forming carbon-carbon bonds
DA85_RS04205	COG0501	Belongs to the peptidase M48B family
DA85_RS04215	COG0436	Aminotransferase
DA85_RS04220	COG1530	ribonuclease E activity
DA85_RS04230	COG0860	N-Acetylmuramoyl-L-alanine amidase
DA85_RS04235	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
DA85_RS04245	COG3293	Transposase
DA85_RS04255	COG2833	Protein of unknown function (DUF455)
DA85_RS04260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DA85_RS04285	COG2945	thiolester hydrolase activity
DA85_RS04295	COG0719	Fe-S assembly protein
DA85_RS04300	COG0396	ATPase activity
DA85_RS04305	COG0719	Fe-S assembly protein
DA85_RS04310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
DA85_RS04315	COG2151	metal-sulfur cluster biosynthetic enzyme
DA85_RS04335	COG0513	Belongs to the DEAD box helicase family
DA85_RS04340	COG0316	Belongs to the HesB IscA family
DA85_RS04355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DA85_RS04385	COG2084	Dehydrogenase
DA85_RS04390	COG0625	glutathione transferase activity
DA85_RS04440	COG2989	Protein conserved in bacteria
DA85_RS04535	COG3293	Transposase
DA85_RS04575	COG1393	Belongs to the ArsC family
DA85_RS04605	COG0084	hydrolase, TatD family'
DA85_RS04640	COG0174	glutamine synthetase
DA85_RS04645	COG0347	Belongs to the P(II) protein family
DA85_RS04650	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DA85_RS04650	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DA85_RS04660	COG0546	phosphoglycolate phosphatase activity
DA85_RS04680	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DA85_RS04685	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DA85_RS04705	COG0281	malic enzyme
DA85_RS04705	COG0280	phosphate acetyltransferase
DA85_RS04710	COG4948	Mandelate Racemase Muconate Lactonizing
DA85_RS04715	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DA85_RS04720	COG1127	ABC transporter
DA85_RS04740	COG0633	Ferredoxin
DA85_RS04755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DA85_RS04765	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DA85_RS04780	COG3106	COG3106 Predicted ATPase
DA85_RS04805	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
DA85_RS04820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DA85_RS04840	COG1546	Belongs to the CinA family
DA85_RS04840	COG1058	Belongs to the CinA family
DA85_RS04855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DA85_RS04860	COG0513	Belongs to the DEAD box helicase family
DA85_RS04865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DA85_RS04870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DA85_RS04875	COG2897	thiosulfate sulfurtransferase activity
DA85_RS04890	COG0427	acetyl-CoA hydrolase
DA85_RS04895	COG2814	Major facilitator Superfamily
DA85_RS04900	COG1566	PFAM secretion protein HlyD family protein
DA85_RS04910	COG0006	proline dipeptidase activity
DA85_RS04915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DA85_RS04925	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DA85_RS04930	COG3956	TIGRFAM MazG family protein
DA85_RS04935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DA85_RS04955	COG1686	Belongs to the peptidase S11 family
DA85_RS04980	COG1752	Esterase of the alpha-beta hydrolase superfamily
DA85_RS05015	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
DA85_RS05035	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DA85_RS05040	COG1960	acyl-CoA dehydrogenase activity
DA85_RS05045	COG0583	DNA-binding transcription factor activity
DA85_RS05050	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA85_RS05055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DA85_RS05060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA85_RS05100	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DA85_RS05105	COG2095	MarC family integral membrane protein
DA85_RS05115	COG2188	Transcriptional regulator
DA85_RS05150	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DA85_RS05165	COG0569	domain protein
DA85_RS05170	COG2204	response regulator
DA85_RS05175	COG5000	phosphorelay sensor kinase activity
DA85_RS05180	COG2204	response regulator
DA85_RS05185	COG3852	Histidine kinase
DA85_RS05200	COG1546	Belongs to the CinA family
DA85_RS05200	COG1058	Belongs to the CinA family
DA85_RS05205	COG1028	Short-chain dehydrogenase reductase Sdr
DA85_RS05210	COG2867	negative regulation of translational initiation
DA85_RS05225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DA85_RS05230	COG0508	dehydrogenase complex catalyzes the overall conversion of
DA85_RS05235	COG0508	dehydrogenase complex catalyzes the overall conversion of
DA85_RS05235	COG0022	dehydrogenase e1 component
DA85_RS05240	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DA85_RS05245	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DA85_RS05285	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DA85_RS05305	COG0303	'Molybdopterin
DA85_RS05325	COG0372	Belongs to the citrate synthase family
DA85_RS05330	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DA85_RS05355	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA85_RS05410	COG0584	glycerophosphoryl diester phosphodiesterase
DA85_RS05420	COG0537	adenosine 5'-monophosphoramidase activity
DA85_RS05435	COG1686	Belongs to the peptidase S11 family
DA85_RS05450	COG1760	l-serine dehydratase
DA85_RS05500	COG3800	Transcriptional regulator
DA85_RS05500	COG1396	sequence-specific DNA binding
DA85_RS05505	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
DA85_RS05510	COG4770	biotin carboxylase activity
DA85_RS05515	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DA85_RS05515	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
DA85_RS05530	COG2358	TRAP transporter, solute receptor (TAXI family
DA85_RS05540	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
DA85_RS05545	COG0693	protein deglycase activity
DA85_RS05555	COG0538	isocitrate dehydrogenase activity
DA85_RS05560	COG1785	Belongs to the alkaline phosphatase family
DA85_RS05575	COG2885	chlorophyll binding
DA85_RS05585	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DA85_RS05590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DA85_RS05635	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DA85_RS05700	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DA85_RS05790	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DA85_RS05815	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DA85_RS05870	COG0346	lactoylglutathione lyase activity
DA85_RS05890	COG1494	fructose-1,6-bisphosphatase
DA85_RS05900	COG0436	Aminotransferase
DA85_RS05935	COG0024	Methionine aminopeptidase
DA85_RS05985	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DA85_RS06140	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DA85_RS06140	COG4651	solute:proton antiporter activity
DA85_RS06155	COG4208	sulfate ABC transporter
DA85_RS06160	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DA85_RS06165	COG4150	thiosulfate binding
DA85_RS06175	COG1253	flavin adenine dinucleotide binding
DA85_RS06180	COG0586	Pfam SNARE associated Golgi protein
DA85_RS06195	COG4154	Belongs to the RbsD FucU family
DA85_RS06200	COG1028	Short-chain dehydrogenase reductase Sdr
DA85_RS06210	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA85_RS06225	COG1120	ATPase activity
DA85_RS06230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DA85_RS06245	COG0842	Transport permease protein
DA85_RS06250	COG0842	Transport permease protein
DA85_RS06250	COG1129	ABC transporter
DA85_RS06255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA85_RS06260	COG1649	PFAM Uncharacterised BCR, COG1649
DA85_RS06300	COG4413	Urea transporter
DA85_RS06310	COG0310	cobalt ion transport
DA85_RS06350	COG0384	phenazine biosynthesis protein PhzF
DA85_RS06370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA85_RS06405	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DA85_RS06410	COG0440	acetolactate synthase activity
DA85_RS06415	COG0028	Belongs to the TPP enzyme family
DA85_RS06425	COG0560	Phosphoserine phosphatase
DA85_RS06430	COG2081	HI0933 family
DA85_RS06445	COG0330	HflC and HflK could
DA85_RS06470	COG2814	Major facilitator Superfamily
DA85_RS06510	COG0277	FAD linked oxidase domain protein
DA85_RS06525	COG0210	DNA helicase
DA85_RS06540	COG1999	signal sequence binding
DA85_RS06550	COG0006	proline dipeptidase activity
DA85_RS06570	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DA85_RS06580	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DA85_RS06585	COG0849	cell division
DA85_RS06590	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DA85_RS06655	COG1914	H( )-stimulated, divalent metal cation uptake system
DA85_RS06665	COG3023	N-Acetylmuramoyl-L-alanine amidase
DA85_RS06670	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DA85_RS06700	COG0640	Transcriptional regulator
DA85_RS06710	COG0477	Major facilitator Superfamily
DA85_RS06730	COG2267	carboxylic ester hydrolase activity
DA85_RS06755	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DA85_RS06760	COG2824	Alkylphosphonate utilization operon protein PhnA
DA85_RS06765	COG1335	isochorismatase
DA85_RS06780	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
DA85_RS06820	COG2968	Membrane
DA85_RS06840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DA85_RS06845	COG0358	DNA primase activity
DA85_RS06865	COG2321	neutral zinc metallopeptidase
DA85_RS06885	COG1136	(ABC) transporter
DA85_RS06895	COG1278	Cold shock
DA85_RS06900	COG0625	glutathione transferase activity
DA85_RS06905	COG0436	Aminotransferase
DA85_RS06915	COG0583	DNA-binding transcription factor activity
DA85_RS06920	COG0492	ferredoxin-NADP+ reductase activity
DA85_RS06925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DA85_RS06930	COG1522	sequence-specific DNA binding
DA85_RS06975	COG0556	nucleotide-excision repair
DA85_RS06980	COG1196	nuclear chromosome segregation
DA85_RS06980	COG0741	lytic transglycosylase activity
DA85_RS06980	COG0739	heme binding
DA85_RS06985	COG1278	Cold shock
DA85_RS06995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DA85_RS07010	COG1846	Transcriptional regulator
DA85_RS07015	COG0745	RESPONSE REGULATOR receiver
DA85_RS07020	COG2205	protein histidine kinase activity
DA85_RS07030	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DA85_RS07055	COG1496	oxidoreductase activity
DA85_RS07075	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DA85_RS07100	COG0012	GTP binding
DA85_RS07105	COG2030	dehydratase
DA85_RS07120	COG2857	Cytochrome c1
DA85_RS07120	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DA85_RS07135	COG1132	(ABC) transporter
DA85_RS07140	COG1132	(ABC) transporter
DA85_RS07145	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DA85_RS07165	COG3153	acetyltransferase
DA85_RS07180	COG0617	tRNA 3'-terminal CCA addition
DA85_RS07195	COG0714	Associated with various cellular activities
DA85_RS07220	COG0435	Glutathione S-transferase
DA85_RS07225	COG3047	cAMP biosynthetic process
DA85_RS07230	COG1051	belongs to the nudix hydrolase family
DA85_RS07245	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DA85_RS07250	COG0512	Glutamine amidotransferase of anthranilate synthase
DA85_RS07250	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DA85_RS07260	COG1522	sequence-specific DNA binding
DA85_RS07290	COG4176	ABC-type proline glycine betaine transport system permease component
DA85_RS07295	COG4175	Glycine betaine
DA85_RS07295	COG3448	diguanylate cyclase activity
DA85_RS07300	COG4608	Belongs to the ABC transporter superfamily
DA85_RS07305	COG0444	Belongs to the ABC transporter superfamily
DA85_RS07310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DA85_RS07315	COG0601	transmembrane transport
DA85_RS07320	COG0747	negative chemotaxis
DA85_RS07325	COG0747	negative chemotaxis
DA85_RS07330	COG0747	negative chemotaxis
DA85_RS07430	COG1177	transmembrane transport
DA85_RS07435	COG1176	ABC-type spermidine putrescine transport system, permease component I
DA85_RS07440	COG3842	ATPase activity
DA85_RS07455	COG2224	Isocitrate lyase
DA85_RS07475	COG1028	Short-chain dehydrogenase reductase Sdr
DA85_RS07480	COG1028	Short-chain dehydrogenase reductase Sdr
DA85_RS07495	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
DA85_RS07510	COG1461	Dihydroxyacetone kinase
DA85_RS07515	COG2376	Dihydroxyacetone kinase
DA85_RS07520	COG1461	Dihydroxyacetone kinase
DA85_RS07525	COG2376	Dihydroxyacetone kinase
DA85_RS07530	COG1028	Short-chain dehydrogenase reductase Sdr
DA85_RS07535	COG1879	ABC-type sugar transport system periplasmic component
DA85_RS07540	COG1172	Belongs to the binding-protein-dependent transport system permease family
DA85_RS07555	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DA85_RS07605	COG1012	belongs to the aldehyde dehydrogenase family
DA85_RS07630	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DA85_RS07645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DA85_RS07650	COG0564	pseudouridine synthase activity
DA85_RS07670	COG2202	Pas domain
DA85_RS07670	COG3920	Histidine kinase
DA85_RS07680	COG0784	Response regulator, receiver
DA85_RS07695	COG3920	Histidine kinase
DA85_RS07725	COG0848	biopolymer transport protein
DA85_RS07740	COG1136	(ABC) transporter
DA85_RS07740	COG4591	ABC-type transport system involved in lipoprotein release permease component
DA85_RS07745	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DA85_RS07755	COG1522	sequence-specific DNA binding
DA85_RS07775	COG0477	Major facilitator Superfamily
DA85_RS07795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DA85_RS07820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DA85_RS07840	COG2885	chlorophyll binding
DA85_RS07855	COG0848	biopolymer transport protein
DA85_RS07910	COG0483	inositol monophosphate 1-phosphatase activity
DA85_RS07925	COG1132	(ABC) transporter
DA85_RS07955	COG1253	flavin adenine dinucleotide binding
DA85_RS07960	COG1692	metallophosphoesterase
DA85_RS08025	COG0604	alcohol dehydrogenase
DA85_RS08025	COG1028	Short-chain dehydrogenase reductase Sdr
DA85_RS08025	COG3321	synthase
DA85_RS08055	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DA85_RS08065	COG0457	Tetratricopeptide repeat
DA85_RS08070	COG0469	pyruvate kinase activity
DA85_RS08090	COG0488	(ABC) transporter
DA85_RS08125	COG2258	MOSC domain
DA85_RS08130	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DA85_RS08135	COG1329	Transcriptional regulator
DA85_RS08140	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DA85_RS08155	COG0183	Belongs to the thiolase family
DA85_RS08175	COG0142	geranyltranstransferase activity
DA85_RS08185	COG1028	Short-chain dehydrogenase reductase Sdr
DA85_RS08190	COG0738	Major facilitator superfamily
DA85_RS08195	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
DA85_RS08235	COG0559	Belongs to the binding-protein-dependent transport system permease family
DA85_RS08245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DA85_RS08310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DA85_RS08320	COG5425	PFAM Usg family protein
DA85_RS08340	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DA85_RS08340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DA85_RS08355	COG2270	Major facilitator Superfamily
DA85_RS08370	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
DA85_RS08375	COG1704	LemA family
DA85_RS08385	COG0287	Prephenate dehydrogenase
DA85_RS08385	COG1605	Chorismate mutase
DA85_RS08390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DA85_RS08400	COG0288	reversible hydration of carbon dioxide
DA85_RS08420	COG0583	DNA-binding transcription factor activity
DA85_RS08440	COG0793	Belongs to the peptidase S41A family
DA85_RS08460	COG0799	negative regulation of ribosome biogenesis
DA85_RS08525	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DA85_RS08580	COG0739	heme binding
DA85_RS08585	COG1376	ErfK ybiS ycfS ynhG family protein
DA85_RS08600	COG2890	protein-(glutamine-N5) methyltransferase activity
DA85_RS08615	COG0527	aspartate kinase activity
DA85_RS08645	COG1040	competence protein
DA85_RS08650	COG2226	methyltransferase
DA85_RS08705	COG2264	protein methyltransferase activity
DA85_RS08710	COG0697	spore germination
DA85_RS08715	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DA85_RS08725	COG0004	ammonium transporteR
DA85_RS08730	COG1946	Acyl-CoA thioesterase
DA85_RS08735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DA85_RS08780	COG1953	Uracil, thiamine, allantoin
DA85_RS08840	COG1280	lysine exporter protein (LysE YggA)
DA85_RS08850	COG0508	dehydrogenase complex catalyzes the overall conversion of
DA85_RS08860	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DA85_RS08875	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DA85_RS08890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DA85_RS08895	COG0552	protein localization to endoplasmic reticulum
DA85_RS08920	COG0494	nUDIX hydrolase
DA85_RS08935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DA85_RS08960	COG2194	sulfuric ester hydrolase activity
DA85_RS08985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DA85_RS08990	COG0765	amino acid transport
DA85_RS08995	COG0765	amino acid transport
DA85_RS09015	COG1126	abc transporter atp-binding protein
DA85_RS09025	COG1802	Transcriptional regulator
DA85_RS09030	COG0252	asparaginase activity
DA85_RS09055	COG1250	3-hydroxyacyl-CoA dehydrogenase
DA85_RS09060	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
DA85_RS09065	COG2086	electron transfer activity
DA85_RS09075	COG0720	synthase
DA85_RS09080	COG0602	queuosine metabolic process
DA85_RS09095	COG0300	oxidoreductase activity
DA85_RS09110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DA85_RS09140	COG2226	methyltransferase
DA85_RS09150	COG0287	Prephenate dehydrogenase
DA85_RS09175	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DA85_RS09195	COG2884	Cell division ATP-binding protein ftsE
DA85_RS09210	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DA85_RS09265	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
DA85_RS09280	COG0789	Transcriptional regulator
DA85_RS09285	COG2217	Heavy metal translocating P-type atpase
DA85_RS09320	COG4536	flavin adenine dinucleotide binding
DA85_RS09360	COG0523	cobalamin synthesis protein
DA85_RS09365	COG1686	Belongs to the peptidase S11 family
DA85_RS09370	COG1473	amidohydrolase
DA85_RS09380	COG1028	Short-chain dehydrogenase reductase Sdr
DA85_RS09400	COG1028	Short-chain dehydrogenase reductase Sdr
DA85_RS09410	COG1012	belongs to the aldehyde dehydrogenase family
DA85_RS09415	COG1024	Enoyl-CoA hydratase
DA85_RS09445	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DA85_RS09455	COG4120	Belongs to the binding-protein-dependent transport system permease family
DA85_RS09460	COG1122	ATPase activity
DA85_RS09495	COG1331	Highly conserved protein containing a thioredoxin domain
DA85_RS09500	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DA85_RS09510	COG1981	membrane
DA85_RS09535	COG0237	dephospho-CoA kinase activity
DA85_RS09555	COG4395	Tim44
DA85_RS09565	COG2840	Smr protein MutS2
DA85_RS09570	COG1396	sequence-specific DNA binding
DA85_RS09635	COG0745	RESPONSE REGULATOR receiver
DA85_RS09640	COG2205	protein histidine kinase activity
DA85_RS09650	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA85_RS09650	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DA85_RS09655	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DA85_RS09665	COG2205	protein histidine kinase activity
DA85_RS09670	COG3178	'Phosphotransferase
DA85_RS09675	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DA85_RS09680	COG2887	Belongs to the helicase family. UvrD subfamily
DA85_RS09685	COG1074	ATP-dependent DNA helicase activity
DA85_RS09695	COG0285	dihydrofolate synthase activity
DA85_RS09725	COG1434	Gram-negative-bacterium-type cell wall biogenesis
DA85_RS09740	COG3135	benzoate transporter
DA85_RS09755	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DA85_RS09805	COG3963	phosphatidate phosphatase activity
DA85_RS09820	COG3386	PFAM SMP-30 Gluconolaconase
DA85_RS09830	COG0606	chelatase, subunit chli
DA85_RS09840	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DA85_RS09845	COG2832	Protein of unknown function (DUF454)
DA85_RS09850	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DA85_RS09855	COG0573	inorganic phosphate transmembrane transporter activity
DA85_RS09865	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
DA85_RS09870	COG0704	Plays a role in the regulation of phosphate uptake
DA85_RS09875	COG0745	RESPONSE REGULATOR receiver
DA85_RS09880	COG3773	Cell wall hydrolase
DA85_RS09890	COG2309	aminopeptidase activity
DA85_RS09895	COG0783	Belongs to the Dps family
DA85_RS09905	COG0456	acetyltransferase
DA85_RS09930	COG4535	Mg2 and Co2 transporter CorC
DA85_RS09940	COG1396	sequence-specific DNA binding
DA85_RS09945	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DA85_RS09960	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DA85_RS09960	COG0195	Participates in both transcription termination and antitermination
DA85_RS09995	COG2813	Specifically methylates the guanine in position
DA85_RS10000	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DA85_RS10040	COG0791	NLP P60 protein
DA85_RS10050	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DA85_RS10065	COG1024	Enoyl-CoA hydratase
DA85_RS10305	COG2816	NAD+ diphosphatase activity
DA85_RS10400	COG0033	Phosphoglucomutase
DA85_RS10630	COG3459	Glycosyltransferase 36 associated
DA85_RS10635	COG3459	Glycosyltransferase 36 associated
DA85_RS11070	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DA85_RS11630	COG0534	Mate efflux family protein
DA85_RS11775	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
DA85_RS12665	COG1879	ABC-type sugar transport system periplasmic component
DA85_RS13315	COG0488	(ABC) transporter
DA85_RS13575	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DA85_RS14330	COG0719	Fe-S assembly protein
DA85_RS15205	COG0569	domain protein
DA85_RS15280	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DA85_RS15285	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DA85_RS15485	COG1760	l-serine dehydratase