locus-tag	class	description
BME20236_RS00025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BME20236_RS00030	COG4172	Belongs to the ABC transporter superfamily
BME20236_RS00035	COG4239	(ABC) transporter, permease
BME20236_RS00040	COG4174	ABC transporter (Permease)
BME20236_RS00050	COG4166	transmembrane transport
BME20236_RS00065	COG0683	leucine binding
BME20236_RS00075	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
BME20236_RS00090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BME20236_RS00095	COG1960	acyl-CoA dehydrogenase activity
BME20236_RS00135	COG0539	negative regulation of cytoplasmic translation
BME20236_RS00140	COG2855	membrane
BME20236_RS00145	COG0583	DNA-binding transcription factor activity
BME20236_RS00150	COG2951	lytic endotransglycosylase activity
BME20236_RS00165	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BME20236_RS00180	COG2816	NAD+ diphosphatase activity
BME20236_RS00185	COG1605	Chorismate mutase
BME20236_RS00185	COG0077	Prephenate dehydratase
BME20236_RS00195	COG3474	cytochrome
BME20236_RS00205	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BME20236_RS00210	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BME20236_RS00215	COG1845	cytochrome c oxidase, subunit III
BME20236_RS00220	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
BME20236_RS00265	COG0346	lactoylglutathione lyase activity
BME20236_RS00270	COG0489	protein tyrosine kinase activity
BME20236_RS00275	COG0033	Phosphoglucomutase
BME20236_RS00285	COG1073	alpha beta
BME20236_RS00290	COG1072	(Pantothenic acid kinase))
BME20236_RS00320	COG1272	protein, Hemolysin III
BME20236_RS00325	COG0587	DNA-directed DNA polymerase activity
BME20236_RS00385	COG3339	Conserved Protein
BME20236_RS00400	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
BME20236_RS00410	COG4181	ATPase activity
BME20236_RS00420	COG0670	Belongs to the BI1 family
BME20236_RS00440	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
BME20236_RS00445	COG4133	protoheme IX ABC transporter activity
BME20236_RS00450	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BME20236_RS00455	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BME20236_RS00465	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME20236_RS00505	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
BME20236_RS00515	COG4208	sulfate ABC transporter
BME20236_RS00520	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
BME20236_RS00525	COG3459	Glycosyltransferase 36 associated
BME20236_RS00535	COG0384	phenazine biosynthesis protein PhzF
BME20236_RS00540	COG2226	methyltransferase
BME20236_RS00550	COG1028	Short-chain dehydrogenase reductase Sdr
BME20236_RS00555	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BME20236_RS00570	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BME20236_RS00575	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BME20236_RS00580	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BME20236_RS00580	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BME20236_RS00605	COG2153	protein acetylation
BME20236_RS00625	COG1643	Atp-dependent helicase
BME20236_RS00635	COG3293	Transposase
BME20236_RS00640	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
BME20236_RS00650	COG1376	ErfK ybiS ycfS ynhG family protein
BME20236_RS00650	COG1388	LysM domain
BME20236_RS00655	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BME20236_RS00665	COG0180	Tryptophanyl-tRNA synthetase
BME20236_RS00670	COG0728	peptidoglycan biosynthetic process
BME20236_RS00680	COG0280	phosphate acetyltransferase
BME20236_RS00680	COG0281	malic enzyme
BME20236_RS00685	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
BME20236_RS00700	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BME20236_RS00720	COG0616	signal peptide processing
BME20236_RS00730	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
BME20236_RS00735	COG1137	ATPase activity
BME20236_RS00740	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BME20236_RS00745	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
BME20236_RS00750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
BME20236_RS00760	COG0071	Belongs to the small heat shock protein (HSP20) family
BME20236_RS00780	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BME20236_RS00785	COG2860	membrane
BME20236_RS00815	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
BME20236_RS00820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BME20236_RS00825	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BME20236_RS00835	COG1648	precorrin-2 dehydrogenase activity
BME20236_RS00835	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
BME20236_RS00845	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
BME20236_RS00850	COG0175	sulfate reduction
BME20236_RS00865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BME20236_RS00885	COG2197	response regulator
BME20236_RS00890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BME20236_RS00905	COG1218	3'(2'),5'-bisphosphate nucleotidase
BME20236_RS00920	COG2197	response regulator
BME20236_RS00940	COG1012	belongs to the aldehyde dehydrogenase family
BME20236_RS00965	COG1012	belongs to the aldehyde dehydrogenase family
BME20236_RS00970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BME20236_RS00975	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BME20236_RS00980	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
BME20236_RS01005	COG0351	phosphomethylpyrimidine kinase
BME20236_RS01010	COG5001	Diguanylate cyclase
BME20236_RS01025	COG1174	glycine betaine transport
BME20236_RS01030	COG1125	glycine betaine transport
BME20236_RS01035	COG1174	glycine betaine transport
BME20236_RS01040	COG1732	Glycine betaine
BME20236_RS01050	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
BME20236_RS01065	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BME20236_RS01065	COG0446	pyridine nucleotide-disulphide oxidoreductase
BME20236_RS01080	COG1414	Transcriptional regulator
BME20236_RS01090	COG1175	transmembrane transport
BME20236_RS01095	COG0395	ABC-type sugar transport system, permease component
BME20236_RS01100	COG3842	ATPase activity
BME20236_RS01105	COG4948	Mandelate Racemase Muconate Lactonizing
BME20236_RS01110	COG3254	rhamnose metabolic process
BME20236_RS01125	COG1028	Short-chain dehydrogenase reductase Sdr
BME20236_RS01135	COG4948	Mandelate Racemase Muconate Lactonizing
BME20236_RS01150	COG0582	viral genome integration into host DNA
BME20236_RS01300	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
BME20236_RS01315	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BME20236_RS01325	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BME20236_RS01355	COG3617	BRO family, N-terminal domain
BME20236_RS01360	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BME20236_RS01380	COG0829	nickel cation binding
BME20236_RS01400	COG0804	urea catabolic process
BME20236_RS01410	COG0830	nickel cation binding
BME20236_RS01425	COG4191	Histidine kinase
BME20236_RS01430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BME20236_RS01435	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BME20236_RS01455	COG0494	nUDIX hydrolase
BME20236_RS01465	COG0493	'glutamate synthase
BME20236_RS01495	COG0318	PFAM AMP-dependent synthetase and ligase
BME20236_RS01530	COG2326	polyphosphate kinase activity
BME20236_RS01535	COG5002	protein histidine kinase activity
BME20236_RS01545	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BME20236_RS01555	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
BME20236_RS01570	COG0717	Belongs to the dCTP deaminase family
BME20236_RS01590	COG0534	Mate efflux family protein
BME20236_RS01620	COG2205	protein histidine kinase activity
BME20236_RS01620	COG2198	Histidine kinase
BME20236_RS01620	COG0784	Response regulator, receiver
BME20236_RS01630	COG0156	8-amino-7-oxononanoate synthase activity
BME20236_RS01655	COG0583	DNA-binding transcription factor activity
BME20236_RS01660	COG1380	Effector of murein hydrolase LrgA
BME20236_RS01665	COG1346	cytolysis
BME20236_RS01695	COG0019	diaminopimelate decarboxylase activity
BME20236_RS01715	COG5342	invasion associated locus B
BME20236_RS01735	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
BME20236_RS01740	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
BME20236_RS01745	COG3257	ureidoglycine aminohydrolase activity
BME20236_RS01750	COG3648	Uricase
BME20236_RS01750	COG3195	allantoin biosynthetic process
BME20236_RS01760	COG2080	2 iron, 2 sulfur cluster binding
BME20236_RS01765	COG1529	Aldehyde oxidase and xanthine dehydrogenase
BME20236_RS01775	COG0583	DNA-binding transcription factor activity
BME20236_RS01785	COG0402	S-adenosylhomocysteine deaminase activity
BME20236_RS01845	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BME20236_RS01845	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
BME20236_RS01855	COG2169	Transcriptional regulator
BME20236_RS01855	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BME20236_RS01860	COG1393	Belongs to the ArsC family
BME20236_RS01870	COG0477	Major facilitator Superfamily
BME20236_RS01875	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
BME20236_RS01900	COG3773	Cell wall hydrolase
BME20236_RS01920	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BME20236_RS01950	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
BME20236_RS01960	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BME20236_RS01960	COG0616	signal peptide processing
BME20236_RS01975	COG0142	geranyltranstransferase activity
BME20236_RS01990	COG0751	glycine-tRNA ligase activity
BME20236_RS01995	COG0009	L-threonylcarbamoyladenylate synthase
BME20236_RS02025	COG1960	acyl-CoA dehydrogenase activity
BME20236_RS02040	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BME20236_RS02055	COG0484	heat shock protein binding
BME20236_RS02060	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BME20236_RS02070	COG1278	Cold shock
BME20236_RS02100	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BME20236_RS02100	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BME20236_RS02105	COG0123	including yeast histone deacetylase and acetoin utilization protein
BME20236_RS02110	COG1722	exodeoxyribonuclease VII activity
BME20236_RS02130	COG1741	Belongs to the pirin family
BME20236_RS02140	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
BME20236_RS02145	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
BME20236_RS02165	COG5265	(ABC) transporter
BME20236_RS02175	COG1183	phosphatidylcholine synthase activity
BME20236_RS02180	COG1028	Short-chain dehydrogenase reductase Sdr
BME20236_RS02185	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BME20236_RS02200	COG0305	Participates in initiation and elongation during chromosome replication
BME20236_RS02205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BME20236_RS02230	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BME20236_RS02245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BME20236_RS02250	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
BME20236_RS02255	COG1561	YicC-like family, N-terminal region
BME20236_RS02260	COG0194	GDP metabolic process
BME20236_RS02265	COG0312	modulator of DNA gyrase
BME20236_RS02275	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BME20236_RS02280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BME20236_RS02315	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
BME20236_RS02330	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BME20236_RS02330	COG0678	peroxiredoxin activity
BME20236_RS02350	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BME20236_RS02355	COG0612	Peptidase, M16
BME20236_RS02370	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BME20236_RS02380	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BME20236_RS02390	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BME20236_RS02400	COG1194	a g-specific adenine glycosylase
BME20236_RS02415	COG1196	nuclear chromosome segregation
BME20236_RS02430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
BME20236_RS02430	COG0574	Belongs to the PEP-utilizing enzyme family
BME20236_RS02455	COG1268	BioY protein
BME20236_RS02465	COG2351	hydroxyisourate hydrolase activity
BME20236_RS02480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BME20236_RS02500	COG2801	Transposase and inactivated derivatives
BME20236_RS02530	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BME20236_RS02560	COG3293	Transposase
BME20236_RS02570	COG2801	Transposase and inactivated derivatives
BME20236_RS02575	COG3293	Transposase
BME20236_RS02590	COG0662	Cupin 2, conserved barrel domain protein
BME20236_RS02590	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
BME20236_RS02595	COG2942	2-epimerase
BME20236_RS02600	COG0438	transferase activity, transferring glycosyl groups
BME20236_RS02600	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BME20236_RS02610	COG1172	Belongs to the binding-protein-dependent transport system permease family
BME20236_RS02615	COG1879	ABC-type sugar transport system periplasmic component
BME20236_RS02625	COG0673	inositol 2-dehydrogenase activity
BME20236_RS02635	COG1070	Carbohydrate kinase
BME20236_RS02665	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
BME20236_RS02680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BME20236_RS02700	COG2186	Transcriptional regulator
BME20236_RS02705	COG2807	transmembrane transport
BME20236_RS02715	COG0433	COG0433 Predicted ATPase
BME20236_RS02720	COG1376	ErfK ybiS ycfS ynhG family protein
BME20236_RS02735	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BME20236_RS02750	COG4957	zinc ion binding
BME20236_RS02760	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BME20236_RS02770	COG0154	amidase activity
BME20236_RS02775	COG2166	iron-sulfur cluster assembly
BME20236_RS02785	COG2205	protein histidine kinase activity
BME20236_RS02815	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BME20236_RS02830	COG4695	Portal protein
BME20236_RS02930	COG4235	cytochrome complex assembly
BME20236_RS02940	COG1138	Cytochrome C-type biogenesis protein
BME20236_RS02945	COG3088	subunit of a heme lyase
BME20236_RS02950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BME20236_RS02955	COG0745	RESPONSE REGULATOR receiver
BME20236_RS02965	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
BME20236_RS02975	COG2205	protein histidine kinase activity
BME20236_RS02975	COG2202	Pas domain
BME20236_RS02980	COG0308	aminopeptidase N
BME20236_RS02995	COG1573	uracil-dna glycosylase
BME20236_RS03010	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BME20236_RS03025	COG0625	glutathione transferase activity
BME20236_RS03060	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BME20236_RS03065	COG4974	Belongs to the 'phage' integrase family
BME20236_RS03070	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
BME20236_RS03095	COG3743	rRNA binding
BME20236_RS03095	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BME20236_RS03100	COG0741	lytic transglycosylase activity
BME20236_RS03140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
BME20236_RS03145	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BME20236_RS03150	COG2223	nitrite transmembrane transporter activity
BME20236_RS03155	COG2207	Transcriptional regulator
BME20236_RS03170	COG0681	Belongs to the peptidase S26 family
BME20236_RS03195	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
BME20236_RS03205	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BME20236_RS03225	COG0494	nUDIX hydrolase
BME20236_RS03250	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BME20236_RS03260	COG0739	heme binding
BME20236_RS03270	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BME20236_RS03275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BME20236_RS03280	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
BME20236_RS03310	COG0488	(ABC) transporter
BME20236_RS03330	COG0314	molybdopterin synthase activity
BME20236_RS03335	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
BME20236_RS03340	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BME20236_RS03355	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BME20236_RS03375	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
BME20236_RS03385	COG0243	molybdopterin cofactor binding
BME20236_RS03395	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BME20236_RS03405	COG0628	permease
BME20236_RS03425	COG1028	Short-chain dehydrogenase reductase Sdr
BME20236_RS03550	COG0626	cystathionine gamma-synthase activity
BME20236_RS03560	COG0671	phosphoesterase, PA-phosphatase related
BME20236_RS03565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BME20236_RS03570	COG4597	amino acid ABC transporter
BME20236_RS03575	COG0765	amino acid transport
BME20236_RS03580	COG1126	abc transporter atp-binding protein
BME20236_RS03595	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BME20236_RS03605	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
BME20236_RS03620	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BME20236_RS03635	COG0113	porphobilinogen synthase activity
BME20236_RS03655	COG2989	Protein conserved in bacteria
BME20236_RS03670	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BME20236_RS03670	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BME20236_RS03690	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
BME20236_RS03695	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BME20236_RS03775	COG0010	Belongs to the arginase family
BME20236_RS03810	COG3293	Transposase
BME20236_RS03855	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BME20236_RS03875	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BME20236_RS03880	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BME20236_RS03920	COG1007	ATP synthesis coupled electron transport
BME20236_RS03935	COG0346	lactoylglutathione lyase activity
BME20236_RS03990	COG0483	inositol monophosphate 1-phosphatase activity
BME20236_RS03995	COG2814	Major facilitator Superfamily
BME20236_RS04030	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BME20236_RS04055	COG2514	catechol 2,3-dioxygenase activity
BME20236_RS04060	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BME20236_RS04080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BME20236_RS04085	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BME20236_RS04090	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BME20236_RS04105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BME20236_RS04110	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
BME20236_RS04115	COG3454	Phosphonate metabolism
BME20236_RS04120	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BME20236_RS04125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BME20236_RS04130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BME20236_RS04155	COG1522	sequence-specific DNA binding
BME20236_RS04160	COG1573	uracil-dna glycosylase
BME20236_RS04185	COG0316	Belongs to the HesB IscA family
BME20236_RS04205	COG1472	Belongs to the glycosyl hydrolase 3 family
BME20236_RS04210	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
BME20236_RS04215	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
BME20236_RS04225	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BME20236_RS04230	COG0805	protein transport
BME20236_RS04245	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BME20236_RS04265	COG1862	Preprotein translocase
BME20236_RS04315	COG0544	peptidyl-prolyl cis-trans isomerase activity
BME20236_RS04335	COG4765	Protein conserved in bacteria
BME20236_RS04345	COG0439	Biotin carboxylase
BME20236_RS04350	COG0511	ligase activity, forming carbon-carbon bonds
BME20236_RS04365	COG0501	Belongs to the peptidase M48B family
BME20236_RS04370	COG0436	Aminotransferase
BME20236_RS04375	COG1530	ribonuclease E activity
BME20236_RS04385	COG0860	N-Acetylmuramoyl-L-alanine amidase
BME20236_RS04390	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
BME20236_RS04400	COG3293	Transposase
BME20236_RS04415	COG2833	Protein of unknown function (DUF455)
BME20236_RS04420	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BME20236_RS04435	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
BME20236_RS04445	COG2945	thiolester hydrolase activity
BME20236_RS04455	COG0719	Fe-S assembly protein
BME20236_RS04460	COG0396	ATPase activity
BME20236_RS04465	COG0719	Fe-S assembly protein
BME20236_RS04470	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BME20236_RS04475	COG2151	metal-sulfur cluster biosynthetic enzyme
BME20236_RS04490	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BME20236_RS04495	COG0513	Belongs to the DEAD box helicase family
BME20236_RS04500	COG0316	Belongs to the HesB IscA family
BME20236_RS04515	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BME20236_RS04530	COG0525	valine-tRNA ligase activity
BME20236_RS04545	COG2084	Dehydrogenase
BME20236_RS04550	COG0625	glutathione transferase activity
BME20236_RS04595	COG2989	Protein conserved in bacteria
BME20236_RS04685	COG3293	Transposase
BME20236_RS04720	COG1393	Belongs to the ArsC family
BME20236_RS04750	COG0084	hydrolase, TatD family'
BME20236_RS04760	COG1132	(ABC) transporter
BME20236_RS04785	COG0174	glutamine synthetase
BME20236_RS04790	COG0347	Belongs to the P(II) protein family
BME20236_RS04795	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BME20236_RS04795	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BME20236_RS04805	COG0546	phosphoglycolate phosphatase activity
BME20236_RS04810	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
BME20236_RS04825	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BME20236_RS04830	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BME20236_RS04840	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BME20236_RS04840	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
BME20236_RS04850	COG0281	malic enzyme
BME20236_RS04850	COG0280	phosphate acetyltransferase
BME20236_RS04855	COG4948	Mandelate Racemase Muconate Lactonizing
BME20236_RS04860	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BME20236_RS04870	COG1127	ABC transporter
BME20236_RS04895	COG0633	Ferredoxin
BME20236_RS04900	COG0492	ferredoxin-NADP+ reductase activity
BME20236_RS04915	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BME20236_RS04925	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BME20236_RS04965	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
BME20236_RS04975	COG0668	transmembrane transport
BME20236_RS04980	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BME20236_RS05000	COG1546	Belongs to the CinA family
BME20236_RS05000	COG1058	Belongs to the CinA family
BME20236_RS05015	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BME20236_RS05020	COG0513	Belongs to the DEAD box helicase family
BME20236_RS05025	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BME20236_RS05030	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BME20236_RS05035	COG2897	thiosulfate sulfurtransferase activity
BME20236_RS05050	COG0427	acetyl-CoA hydrolase
BME20236_RS05055	COG2814	Major facilitator Superfamily
BME20236_RS05060	COG1566	PFAM secretion protein HlyD family protein
BME20236_RS05070	COG0006	proline dipeptidase activity
BME20236_RS05075	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
BME20236_RS05085	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BME20236_RS05090	COG3956	TIGRFAM MazG family protein
BME20236_RS05095	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BME20236_RS05120	COG1686	Belongs to the peptidase S11 family
BME20236_RS05145	COG1752	Esterase of the alpha-beta hydrolase superfamily
BME20236_RS05175	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
BME20236_RS05185	COG3617	BRO family, N-terminal domain
BME20236_RS05195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BME20236_RS05200	COG1960	acyl-CoA dehydrogenase activity
BME20236_RS05205	COG0583	DNA-binding transcription factor activity
BME20236_RS05210	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BME20236_RS05215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
BME20236_RS05220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BME20236_RS05260	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BME20236_RS05265	COG2095	MarC family integral membrane protein
BME20236_RS05275	COG2188	Transcriptional regulator
BME20236_RS05285	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BME20236_RS05295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BME20236_RS05310	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
BME20236_RS05325	COG0569	domain protein
BME20236_RS05330	COG2204	response regulator
BME20236_RS05335	COG5000	phosphorelay sensor kinase activity
BME20236_RS05340	COG2204	response regulator
BME20236_RS05345	COG3852	Histidine kinase
BME20236_RS05360	COG1546	Belongs to the CinA family
BME20236_RS05360	COG1058	Belongs to the CinA family
BME20236_RS05365	COG1028	Short-chain dehydrogenase reductase Sdr
BME20236_RS05370	COG2867	negative regulation of translational initiation
BME20236_RS05385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BME20236_RS05390	COG0508	dehydrogenase complex catalyzes the overall conversion of
BME20236_RS05395	COG0508	dehydrogenase complex catalyzes the overall conversion of
BME20236_RS05395	COG0022	dehydrogenase e1 component
BME20236_RS05400	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BME20236_RS05405	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
BME20236_RS05445	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BME20236_RS05465	COG0303	'Molybdopterin
BME20236_RS05475	COG2333	competence protein COMEC
BME20236_RS05475	COG0658	competence protein
BME20236_RS05485	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BME20236_RS05490	COG0372	Belongs to the citrate synthase family
BME20236_RS05495	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BME20236_RS05520	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BME20236_RS05525	COG0750	zinc metalloprotease
BME20236_RS05545	COG0528	UMP kinase activity
BME20236_RS05575	COG0584	glycerophosphoryl diester phosphodiesterase
BME20236_RS05585	COG0537	adenosine 5'-monophosphoramidase activity
BME20236_RS05600	COG1686	Belongs to the peptidase S11 family
BME20236_RS05615	COG1760	l-serine dehydratase
BME20236_RS05665	COG1396	sequence-specific DNA binding
BME20236_RS05665	COG3800	Transcriptional regulator
BME20236_RS05670	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
BME20236_RS05675	COG4770	biotin carboxylase activity
BME20236_RS05680	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BME20236_RS05680	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
BME20236_RS05695	COG2358	TRAP transporter, solute receptor (TAXI family
BME20236_RS05705	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
BME20236_RS05710	COG0693	protein deglycase activity
BME20236_RS05720	COG0538	isocitrate dehydrogenase activity
BME20236_RS05725	COG1785	Belongs to the alkaline phosphatase family
BME20236_RS05740	COG2885	chlorophyll binding
BME20236_RS05750	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BME20236_RS05755	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BME20236_RS05800	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BME20236_RS05865	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BME20236_RS05955	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BME20236_RS05980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BME20236_RS05985	COG0516	GMP reductase activity
BME20236_RS05985	COG0517	IMP dehydrogenase activity
BME20236_RS06015	COG3293	Transposase
BME20236_RS06045	COG0346	lactoylglutathione lyase activity
BME20236_RS06060	COG1181	Belongs to the D-alanine--D-alanine ligase family
BME20236_RS06065	COG1494	fructose-1,6-bisphosphatase
BME20236_RS06075	COG0436	Aminotransferase
BME20236_RS06110	COG0024	Methionine aminopeptidase
BME20236_RS06165	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
BME20236_RS06175	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
BME20236_RS06280	COG0583	DNA-binding transcription factor activity
BME20236_RS06295	COG3976	FMN-binding domain protein
BME20236_RS06295	COG1053	succinate dehydrogenase
BME20236_RS06310	COG3264	Mechanosensitive ion channel
BME20236_RS06310	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
BME20236_RS06325	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BME20236_RS06325	COG4651	solute:proton antiporter activity
BME20236_RS06345	COG4208	sulfate ABC transporter
BME20236_RS06350	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
BME20236_RS06355	COG4150	thiosulfate binding
BME20236_RS06365	COG1253	flavin adenine dinucleotide binding
BME20236_RS06370	COG0586	Pfam SNARE associated Golgi protein
BME20236_RS06385	COG4154	Belongs to the RbsD FucU family
BME20236_RS06390	COG1028	Short-chain dehydrogenase reductase Sdr
BME20236_RS06400	COG1172	Belongs to the binding-protein-dependent transport system permease family
BME20236_RS06415	COG1120	ATPase activity
BME20236_RS06420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BME20236_RS06435	COG0842	Transport permease protein
BME20236_RS06445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BME20236_RS06450	COG1649	PFAM Uncharacterised BCR, COG1649
BME20236_RS06465	COG0804	urea catabolic process
BME20236_RS06490	COG4413	Urea transporter
BME20236_RS06500	COG0310	cobalt ion transport
BME20236_RS06520	COG3439	Domain of unknown function DUF302
BME20236_RS06520	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BME20236_RS06540	COG0384	phenazine biosynthesis protein PhzF
BME20236_RS06560	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BME20236_RS06580	COG3158	transport of potassium into the cell
BME20236_RS06595	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BME20236_RS06600	COG0440	acetolactate synthase activity
BME20236_RS06605	COG0028	Belongs to the TPP enzyme family
BME20236_RS06615	COG0560	Phosphoserine phosphatase
BME20236_RS06635	COG0330	HflC and HflK could
BME20236_RS06665	COG2814	Major facilitator Superfamily
BME20236_RS06705	COG0277	FAD linked oxidase domain protein
BME20236_RS06720	COG0210	DNA helicase
BME20236_RS06735	COG1999	signal sequence binding
BME20236_RS06745	COG0006	proline dipeptidase activity
BME20236_RS06765	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BME20236_RS06775	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BME20236_RS06780	COG0849	cell division
BME20236_RS06785	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
BME20236_RS06790	COG1181	Belongs to the D-alanine--D-alanine ligase family
BME20236_RS06830	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BME20236_RS06850	COG1914	H( )-stimulated, divalent metal cation uptake system
BME20236_RS06865	COG3023	N-Acetylmuramoyl-L-alanine amidase
BME20236_RS06870	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BME20236_RS06900	COG0640	Transcriptional regulator
BME20236_RS06910	COG0477	Major facilitator Superfamily
BME20236_RS06930	COG2267	carboxylic ester hydrolase activity
BME20236_RS06950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BME20236_RS06955	COG2824	Alkylphosphonate utilization operon protein PhnA
BME20236_RS06960	COG1335	isochorismatase
BME20236_RS06975	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
BME20236_RS07015	COG2968	Membrane
BME20236_RS07035	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BME20236_RS07040	COG0358	DNA primase activity
BME20236_RS07060	COG2321	neutral zinc metallopeptidase
BME20236_RS07075	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BME20236_RS07080	COG1136	(ABC) transporter
BME20236_RS07090	COG1278	Cold shock
BME20236_RS07095	COG0625	glutathione transferase activity
BME20236_RS07100	COG0436	Aminotransferase
BME20236_RS07115	COG0583	DNA-binding transcription factor activity
BME20236_RS07120	COG0492	ferredoxin-NADP+ reductase activity
BME20236_RS07125	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BME20236_RS07130	COG1522	sequence-specific DNA binding
BME20236_RS07175	COG0556	nucleotide-excision repair
BME20236_RS07180	COG1196	nuclear chromosome segregation
BME20236_RS07180	COG0741	lytic transglycosylase activity
BME20236_RS07180	COG0739	heme binding
BME20236_RS07185	COG1278	Cold shock
BME20236_RS07195	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
BME20236_RS07215	COG1846	Transcriptional regulator
BME20236_RS07220	COG0745	RESPONSE REGULATOR receiver
BME20236_RS07225	COG2205	protein histidine kinase activity
BME20236_RS07235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BME20236_RS07260	COG1496	oxidoreductase activity
BME20236_RS07280	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BME20236_RS07300	COG0012	GTP binding
BME20236_RS07305	COG2030	dehydratase
BME20236_RS07320	COG2857	Cytochrome c1
BME20236_RS07320	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BME20236_RS07335	COG1132	(ABC) transporter
BME20236_RS07340	COG1132	(ABC) transporter
BME20236_RS07345	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BME20236_RS07365	COG3153	acetyltransferase
BME20236_RS07380	COG0617	tRNA 3'-terminal CCA addition
BME20236_RS07395	COG0714	Associated with various cellular activities
BME20236_RS07420	COG0435	Glutathione S-transferase
BME20236_RS07425	COG3047	cAMP biosynthetic process
BME20236_RS07430	COG1051	belongs to the nudix hydrolase family
BME20236_RS07440	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
BME20236_RS07445	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BME20236_RS07450	COG0512	Glutamine amidotransferase of anthranilate synthase
BME20236_RS07450	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BME20236_RS07460	COG1522	sequence-specific DNA binding
BME20236_RS07490	COG4176	ABC-type proline glycine betaine transport system permease component
BME20236_RS07495	COG4175	Glycine betaine
BME20236_RS07500	COG4608	Belongs to the ABC transporter superfamily
BME20236_RS07505	COG0444	Belongs to the ABC transporter superfamily
BME20236_RS07510	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BME20236_RS07515	COG0601	transmembrane transport
BME20236_RS07615	COG2205	protein histidine kinase activity
BME20236_RS07625	COG1177	transmembrane transport
BME20236_RS07630	COG1176	ABC-type spermidine putrescine transport system, permease component I
BME20236_RS07635	COG3842	ATPase activity
BME20236_RS07645	COG3800	Transcriptional regulator
BME20236_RS07645	COG1396	sequence-specific DNA binding
BME20236_RS07650	COG3800	Transcriptional regulator
BME20236_RS07650	COG1396	sequence-specific DNA binding
BME20236_RS07655	COG2224	Isocitrate lyase
BME20236_RS07670	COG1028	Short-chain dehydrogenase reductase Sdr
BME20236_RS07675	COG1028	Short-chain dehydrogenase reductase Sdr
BME20236_RS07690	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BME20236_RS07705	COG1461	Dihydroxyacetone kinase
BME20236_RS07710	COG2376	Dihydroxyacetone kinase
BME20236_RS07715	COG1461	Dihydroxyacetone kinase
BME20236_RS07720	COG2376	Dihydroxyacetone kinase
BME20236_RS07730	COG1879	ABC-type sugar transport system periplasmic component
BME20236_RS07735	COG1172	Belongs to the binding-protein-dependent transport system permease family
BME20236_RS07740	COG1129	ABC transporter
BME20236_RS07795	COG1012	belongs to the aldehyde dehydrogenase family
BME20236_RS07820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BME20236_RS07835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BME20236_RS07840	COG0564	pseudouridine synthase activity
BME20236_RS07855	COG0735	belongs to the Fur family
BME20236_RS07870	COG0784	Response regulator, receiver
BME20236_RS07885	COG3920	Histidine kinase
BME20236_RS07920	COG0848	biopolymer transport protein
BME20236_RS07935	COG1136	(ABC) transporter
BME20236_RS07935	COG4591	ABC-type transport system involved in lipoprotein release permease component
BME20236_RS07940	COG1136	(ABC) transporter
BME20236_RS07940	COG4591	ABC-type transport system involved in lipoprotein release permease component
BME20236_RS07945	COG4591	ABC-type transport system involved in lipoprotein release permease component
BME20236_RS07945	COG1136	(ABC) transporter
BME20236_RS07950	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BME20236_RS07960	COG1522	sequence-specific DNA binding
BME20236_RS07985	COG0477	Major facilitator Superfamily
BME20236_RS08005	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BME20236_RS08015	COG0385	Bile acid
BME20236_RS08025	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BME20236_RS08030	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BME20236_RS08050	COG2885	chlorophyll binding
BME20236_RS08065	COG0848	biopolymer transport protein
BME20236_RS08075	COG0824	Thioesterase
BME20236_RS08120	COG0483	inositol monophosphate 1-phosphatase activity
BME20236_RS08135	COG1132	(ABC) transporter
BME20236_RS08165	COG1253	flavin adenine dinucleotide binding
BME20236_RS08170	COG1692	metallophosphoesterase
BME20236_RS08240	COG0604	alcohol dehydrogenase
BME20236_RS08240	COG1028	Short-chain dehydrogenase reductase Sdr
BME20236_RS08240	COG3321	synthase
BME20236_RS08265	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BME20236_RS08270	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
BME20236_RS08280	COG0457	Tetratricopeptide repeat
BME20236_RS08285	COG0469	pyruvate kinase activity
BME20236_RS08300	COG3750	Belongs to the UPF0335 family
BME20236_RS08305	COG0488	(ABC) transporter
BME20236_RS08320	COG4143	(ABC) transporter
BME20236_RS08325	COG1178	ABC-type Fe3 transport system permease component
BME20236_RS08340	COG2258	MOSC domain
BME20236_RS08345	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BME20236_RS08350	COG1329	Transcriptional regulator
BME20236_RS08355	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
BME20236_RS08370	COG0183	Belongs to the thiolase family
BME20236_RS08390	COG0142	geranyltranstransferase activity
BME20236_RS08400	COG1028	Short-chain dehydrogenase reductase Sdr
BME20236_RS08405	COG0738	Major facilitator superfamily
BME20236_RS08410	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
BME20236_RS08420	COG0683	leucine binding
BME20236_RS08450	COG3938	Belongs to the proline racemase family
BME20236_RS08520	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BME20236_RS08530	COG5425	PFAM Usg family protein
BME20236_RS08550	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BME20236_RS08550	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BME20236_RS08565	COG2270	Major facilitator Superfamily
BME20236_RS08580	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
BME20236_RS08585	COG1704	LemA family
BME20236_RS08595	COG1605	Chorismate mutase
BME20236_RS08595	COG0287	Prephenate dehydrogenase
BME20236_RS08600	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BME20236_RS08610	COG0288	reversible hydration of carbon dioxide
BME20236_RS08650	COG0793	Belongs to the peptidase S41A family
BME20236_RS08670	COG0799	negative regulation of ribosome biogenesis
BME20236_RS08735	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BME20236_RS08790	COG0739	heme binding
BME20236_RS08800	COG0542	response to heat
BME20236_RS08810	COG2890	protein-(glutamine-N5) methyltransferase activity
BME20236_RS08825	COG0527	aspartate kinase activity
BME20236_RS08855	COG1040	competence protein
BME20236_RS08860	COG2226	methyltransferase
BME20236_RS08915	COG2264	protein methyltransferase activity
BME20236_RS08920	COG0697	spore germination
BME20236_RS08925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
BME20236_RS08930	COG1674	ftsk spoiiie
BME20236_RS08935	COG0004	ammonium transporteR
BME20236_RS08940	COG1946	Acyl-CoA thioesterase
BME20236_RS08945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BME20236_RS08990	COG1953	Uracil, thiamine, allantoin
BME20236_RS09050	COG1280	lysine exporter protein (LysE YggA)
BME20236_RS09060	COG0508	dehydrogenase complex catalyzes the overall conversion of
BME20236_RS09070	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BME20236_RS09085	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
BME20236_RS09100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BME20236_RS09105	COG0552	protein localization to endoplasmic reticulum
BME20236_RS09130	COG0494	nUDIX hydrolase
BME20236_RS09140	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
BME20236_RS09145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BME20236_RS09170	COG2194	sulfuric ester hydrolase activity
BME20236_RS09200	COG0765	amino acid transport
BME20236_RS09205	COG0765	amino acid transport
BME20236_RS09225	COG1126	abc transporter atp-binding protein
BME20236_RS09235	COG1802	Transcriptional regulator
BME20236_RS09240	COG0252	asparaginase activity
BME20236_RS09265	COG1250	3-hydroxyacyl-CoA dehydrogenase
BME20236_RS09270	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
BME20236_RS09275	COG2086	electron transfer activity
BME20236_RS09285	COG0720	synthase
BME20236_RS09290	COG0602	queuosine metabolic process
BME20236_RS09305	COG0300	oxidoreductase activity
BME20236_RS09320	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BME20236_RS09350	COG2226	methyltransferase
BME20236_RS09355	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BME20236_RS09360	COG0287	Prephenate dehydrogenase
BME20236_RS09385	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BME20236_RS09405	COG2884	Cell division ATP-binding protein ftsE
BME20236_RS09415	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
BME20236_RS09420	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BME20236_RS09475	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
BME20236_RS09490	COG0789	Transcriptional regulator
BME20236_RS09495	COG2217	Heavy metal translocating P-type atpase
BME20236_RS09530	COG4536	flavin adenine dinucleotide binding
BME20236_RS09550	COG4974	Belongs to the 'phage' integrase family
BME20236_RS09570	COG0523	cobalamin synthesis protein
BME20236_RS09575	COG1686	Belongs to the peptidase S11 family
BME20236_RS09590	COG1028	Short-chain dehydrogenase reductase Sdr
BME20236_RS09610	COG1028	Short-chain dehydrogenase reductase Sdr
BME20236_RS09620	COG1012	belongs to the aldehyde dehydrogenase family
BME20236_RS09625	COG1024	Enoyl-CoA hydratase
BME20236_RS09650	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
BME20236_RS09665	COG4120	Belongs to the binding-protein-dependent transport system permease family
BME20236_RS09670	COG0410	ABC transporter
BME20236_RS09700	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BME20236_RS09710	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BME20236_RS09720	COG1981	membrane
BME20236_RS09735	COG0424	maF-like protein
BME20236_RS09745	COG0237	dephospho-CoA kinase activity
BME20236_RS09765	COG4395	Tim44
BME20236_RS09775	COG2840	Smr protein MutS2
BME20236_RS09780	COG1396	sequence-specific DNA binding
BME20236_RS09810	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BME20236_RS09845	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BME20236_RS09850	COG0745	RESPONSE REGULATOR receiver
BME20236_RS09855	COG2205	protein histidine kinase activity
BME20236_RS09865	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
BME20236_RS09865	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
BME20236_RS09870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
BME20236_RS09880	COG2205	protein histidine kinase activity
BME20236_RS09885	COG3178	'Phosphotransferase
BME20236_RS09890	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BME20236_RS09895	COG2887	Belongs to the helicase family. UvrD subfamily
BME20236_RS09900	COG1074	ATP-dependent DNA helicase activity
BME20236_RS09910	COG0285	dihydrofolate synthase activity
BME20236_RS09940	COG1434	Gram-negative-bacterium-type cell wall biogenesis
BME20236_RS09960	COG3135	benzoate transporter
BME20236_RS09975	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BME20236_RS10030	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BME20236_RS10045	COG3386	PFAM SMP-30 Gluconolaconase
BME20236_RS10050	COG0189	ligase activity
BME20236_RS10055	COG0606	chelatase, subunit chli
BME20236_RS10065	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BME20236_RS10070	COG2832	Protein of unknown function (DUF454)
BME20236_RS10075	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BME20236_RS10080	COG0573	inorganic phosphate transmembrane transporter activity
BME20236_RS10090	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
BME20236_RS10095	COG0704	Plays a role in the regulation of phosphate uptake
BME20236_RS10100	COG0745	RESPONSE REGULATOR receiver
BME20236_RS10105	COG3773	Cell wall hydrolase
BME20236_RS10115	COG2309	aminopeptidase activity
BME20236_RS10120	COG0783	Belongs to the Dps family
BME20236_RS10130	COG0456	acetyltransferase
BME20236_RS10140	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BME20236_RS10160	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BME20236_RS10165	COG1396	sequence-specific DNA binding
BME20236_RS10170	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BME20236_RS10175	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BME20236_RS10185	COG0195	Participates in both transcription termination and antitermination
BME20236_RS10185	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BME20236_RS10205	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BME20236_RS10220	COG2813	Specifically methylates the guanine in position
BME20236_RS10225	COG2813	Specifically methylates the guanine in position
BME20236_RS10230	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BME20236_RS10270	COG0791	NLP P60 protein
BME20236_RS10280	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BME20236_RS10295	COG1024	Enoyl-CoA hydratase
BME20236_RS10320	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BME20236_RS10325	COG1957	nucleoside hydrolase
BME20236_RS10330	COG1079	Belongs to the binding-protein-dependent transport system permease family
BME20236_RS10340	COG3845	ABC transporter
BME20236_RS10360	COG1028	Short-chain dehydrogenase reductase Sdr
BME20236_RS10365	COG1535	isochorismatase
BME20236_RS10365	COG3433	isochorismatase activity
BME20236_RS10370	COG1021	2,3-dihydroxybenzoate-AMP ligase
BME20236_RS10375	COG1169	isochorismate synthase
BME20236_RS10380	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
BME20236_RS10380	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BME20236_RS10385	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BME20236_RS10400	COG1595	DNA-templated transcription, initiation
BME20236_RS10405	COG4944	Protein of unknown function (DUF1109)
BME20236_RS10410	COG2186	Transcriptional regulator
BME20236_RS10445	COG1028	Short-chain dehydrogenase reductase Sdr
BME20236_RS10450	COG1028	Short-chain dehydrogenase reductase Sdr
BME20236_RS10460	COG0508	dehydrogenase complex catalyzes the overall conversion of
BME20236_RS10465	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BME20236_RS10495	COG4191	Histidine kinase
BME20236_RS10500	COG4566	intracellular signal transduction
BME20236_RS10520	COG0483	inositol monophosphate 1-phosphatase activity
BME20236_RS10535	COG0071	Belongs to the small heat shock protein (HSP20) family
BME20236_RS10545	COG0069	glutamate synthase activity
BME20236_RS10545	COG0067	glutamate synthase
BME20236_RS10545	COG0070	glutamate synthase
BME20236_RS10555	COG1113	amino acid transport
BME20236_RS10565	COG2885	chlorophyll binding
BME20236_RS10570	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
BME20236_RS10575	COG2948	multi-organism process
BME20236_RS10595	COG3704	protein secretion by the type IV secretion system
BME20236_RS10620	COG0741	lytic transglycosylase activity
BME20236_RS10625	COG2951	lytic endotransglycosylase activity
BME20236_RS10630	COG1210	Utp--glucose-1-phosphate uridylyltransferase
BME20236_RS10650	COG0330	HflC and HflK could
BME20236_RS10685	COG2204	response regulator
BME20236_RS10690	COG3108	Peptidase M15
BME20236_RS10695	COG0800	Aldolase
BME20236_RS10710	COG0725	ABC transporter, periplasmic molybdate-binding protein
BME20236_RS10715	COG4149	molybdate abc transporter
BME20236_RS10720	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BME20236_RS10740	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
BME20236_RS10750	COG0583	DNA-binding transcription factor activity
BME20236_RS10755	COG0154	amidase activity
BME20236_RS10765	COG3206	protein involved in exopolysaccharide biosynthesis
BME20236_RS10765	COG0489	protein tyrosine kinase activity
BME20236_RS10800	COG0673	inositol 2-dehydrogenase activity
BME20236_RS10840	COG1309	transcriptional regulator
BME20236_RS10855	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BME20236_RS10860	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BME20236_RS10865	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BME20236_RS10870	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BME20236_RS10885	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BME20236_RS10895	COG4786	Flagellar basal body rod
BME20236_RS10900	COG1157	protein secretion by the type III secretion system
BME20236_RS10910	COG0671	phosphoesterase, PA-phosphatase related
BME20236_RS10920	COG0463	Glycosyl transferase, family 2
BME20236_RS10930	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
BME20236_RS10945	COG2963	transposase activity
BME20236_RS10950	COG2271	Major facilitator Superfamily
BME20236_RS10955	COG0235	Class ii aldolase
BME20236_RS10960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BME20236_RS10965	COG1349	DNA-binding transcription factor activity
BME20236_RS10970	COG3622	Belongs to the hyi family
BME20236_RS10975	COG3395	kinase activity
BME20236_RS10980	COG2084	Dehydrogenase
BME20236_RS10985	COG1815	bacterial-type flagellum-dependent cell motility
BME20236_RS10990	COG1558	bacterial-type flagellum-dependent cell motility
BME20236_RS11000	COG4786	Flagellar basal body rod
BME20236_RS11005	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
BME20236_RS11010	COG1706	bacterial-type flagellum-dependent cell motility
BME20236_RS11030	COG1338	Plays a role in the flagellum-specific transport system
BME20236_RS11045	COG0583	DNA-binding transcription factor activity
BME20236_RS11055	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
BME20236_RS11070	COG3038	cytochrome b561
BME20236_RS11105	COG2186	Transcriptional regulator
BME20236_RS11110	COG0583	DNA-binding transcription factor activity
BME20236_RS11115	COG0277	FAD linked oxidase domain protein
BME20236_RS11125	COG0247	lactate metabolic process
BME20236_RS11130	COG0656	L-ascorbic acid biosynthetic process
BME20236_RS11135	COG1376	ErfK ybiS ycfS ynhG family protein
BME20236_RS11135	COG1388	LysM domain
BME20236_RS11140	COG2818	Glycosylase
BME20236_RS11175	COG2259	Doxx family
BME20236_RS11205	COG0196	riboflavin kinase activity
BME20236_RS11210	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BME20236_RS11225	COG0590	tRNA wobble adenosine to inosine editing
BME20236_RS11235	COG0742	ribosomal rna small subunit methyltransferase
BME20236_RS11240	COG0612	Peptidase, M16
BME20236_RS11245	COG0612	Peptidase, M16
BME20236_RS11255	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BME20236_RS11255	COG0475	glutathione-regulated potassium exporter activity
BME20236_RS11260	COG0312	modulator of DNA gyrase
BME20236_RS11280	COG1519	Transferase
BME20236_RS11300	COG2814	Major facilitator Superfamily
BME20236_RS11305	COG1960	acyl-CoA dehydrogenase activity
BME20236_RS11315	COG1024	Enoyl-CoA hydratase
BME20236_RS11320	COG1250	3-hydroxyacyl-CoA dehydrogenase
BME20236_RS11325	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BME20236_RS11370	COG1477	protein flavinylation
BME20236_RS11395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BME20236_RS11400	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
BME20236_RS11420	COG1845	cytochrome c oxidase, subunit III
BME20236_RS11435	COG3256	nitric oxide reductase
BME20236_RS11440	COG0714	Associated with various cellular activities
BME20236_RS11445	COG4548	von Willebrand factor, type A
BME20236_RS11465	COG2151	metal-sulfur cluster biosynthetic enzyme
BME20236_RS11515	COG4214	carbohydrate transport
BME20236_RS11525	COG1069	ribulokinase activity
BME20236_RS11530	COG5654	RES domain protein
BME20236_RS11540	COG4178	(ABC) transporter
BME20236_RS11585	COG1477	protein flavinylation
BME20236_RS11610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BME20236_RS11625	COG0826	peptidase U32
BME20236_RS11635	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BME20236_RS11650	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BME20236_RS11655	COG2181	nitrate reductase activity
BME20236_RS11660	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
BME20236_RS11665	COG1140	nitrate reductase beta subunit
BME20236_RS11670	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
BME20236_RS11675	COG2223	nitrite transmembrane transporter activity
BME20236_RS11685	COG1609	Transcriptional regulator
BME20236_RS11690	COG1653	transport
BME20236_RS11715	COG0673	inositol 2-dehydrogenase activity
BME20236_RS11730	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
BME20236_RS11755	COG2894	cell division
BME20236_RS11785	COG3842	ATPase activity
BME20236_RS11790	COG1176	ABC-type spermidine putrescine transport system, permease component I
BME20236_RS11795	COG1177	transmembrane transport
BME20236_RS11840	COG0531	amino acid
BME20236_RS11860	COG4943	cyclic-guanylate-specific phosphodiesterase activity
BME20236_RS11880	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
BME20236_RS11885	COG3191	aminopeptidase activity
BME20236_RS11900	COG3258	Cytochrome c
BME20236_RS11905	COG0583	DNA-binding transcription factor activity
BME20236_RS11910	COG0753	catalase activity
BME20236_RS11930	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BME20236_RS11930	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
BME20236_RS11970	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
BME20236_RS11975	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BME20236_RS11985	COG2124	cytochrome p450
BME20236_RS11990	COG1802	Transcriptional regulator
BME20236_RS11995	COG1028	Short-chain dehydrogenase reductase Sdr
BME20236_RS11995	COG0604	alcohol dehydrogenase
BME20236_RS11995	COG3321	synthase
BME20236_RS12020	COG1028	Short-chain dehydrogenase reductase Sdr
BME20236_RS12025	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BME20236_RS12040	COG0683	leucine binding
BME20236_RS12070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BME20236_RS12085	COG0747	negative chemotaxis
BME20236_RS12090	COG2186	Transcriptional regulator
BME20236_RS12095	COG1940	carbohydrate kinase activity
BME20236_RS12095	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
BME20236_RS12100	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
BME20236_RS12115	COG2197	response regulator
BME20236_RS12135	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
BME20236_RS12155	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BME20236_RS12160	COG0110	maltose O-acetyltransferase activity
BME20236_RS12180	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
BME20236_RS12205	COG0438	transferase activity, transferring glycosyl groups
BME20236_RS12220	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BME20236_RS12225	COG4310	Domain of unknown function (DUF2172)
BME20236_RS12230	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
BME20236_RS12245	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
BME20236_RS12250	COG2233	PERMEase
BME20236_RS12270	COG0583	DNA-binding transcription factor activity
BME20236_RS12275	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BME20236_RS12280	COG1960	acyl-CoA dehydrogenase activity
BME20236_RS12285	COG0183	Belongs to the thiolase family
BME20236_RS12295	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BME20236_RS12300	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
BME20236_RS12315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BME20236_RS12320	COG0242	peptide deformylase activity
BME20236_RS12325	COG2354	Protein conserved in bacteria
BME20236_RS12330	COG0640	Transcriptional regulator
BME20236_RS12365	COG1131	(ABC) transporter
BME20236_RS12370	COG0842	Transport permease protein
BME20236_RS12380	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
BME20236_RS12415	COG2205	protein histidine kinase activity
BME20236_RS12440	COG1252	NADH dehydrogenase
BME20236_RS12460	COG1115	amino acid carrier protein
BME20236_RS12480	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BME20236_RS12485	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BME20236_RS12495	COG0156	8-amino-7-oxononanoate synthase activity
BME20236_RS12510	COG0521	Mo-molybdopterin cofactor biosynthetic process
BME20236_RS12525	COG2111	Na H antiporter
BME20236_RS12525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BME20236_RS12530	COG1006	Multisubunit Na H antiporter MnhC subunit
BME20236_RS12535	COG0651	ATP synthesis coupled electron transport
BME20236_RS12540	COG1863	multisubunit Na H antiporter MnhE subunit
BME20236_RS12545	COG2212	antiporter activity
BME20236_RS12560	COG4988	ABC transporter
BME20236_RS12565	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
BME20236_RS12570	COG1271	oxidase subunit
BME20236_RS12575	COG1294	oxidase, subunit
BME20236_RS12585	COG2188	Transcriptional regulator
BME20236_RS12590	COG2971	BadF BadG BcrA BcrD
BME20236_RS12605	COG1175	transmembrane transport
BME20236_RS12610	COG0395	ABC-type sugar transport system, permease component
BME20236_RS12615	COG0673	inositol 2-dehydrogenase activity
BME20236_RS12635	COG0022	dehydrogenase e1 component
BME20236_RS12665	COG0477	Major facilitator Superfamily
BME20236_RS12670	COG3145	DNA-N1-methyladenine dioxygenase activity
BME20236_RS12675	COG4172	Belongs to the ABC transporter superfamily
BME20236_RS12680	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BME20236_RS12685	COG0601	transmembrane transport
BME20236_RS12705	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BME20236_RS12720	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
BME20236_RS12750	COG3293	Transposase
BME20236_RS12770	COG2433	Pfam Transposase IS66
BME20236_RS12775	COG3436	PFAM IS66 Orf2 family protein
BME20236_RS12780	COG2963	transposase activity
BME20236_RS12785	COG3293	Transposase
BME20236_RS12805	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
BME20236_RS12810	COG1959	2 iron, 2 sulfur cluster binding
BME20236_RS12845	COG4603	Belongs to the binding-protein-dependent transport system permease family
BME20236_RS12850	COG3845	ABC transporter
BME20236_RS12860	COG1183	phosphatidylcholine synthase activity
BME20236_RS12865	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
BME20236_RS12890	COG0346	lactoylglutathione lyase activity
BME20236_RS12895	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BME20236_RS12900	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
BME20236_RS12910	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BME20236_RS12920	COG0785	Cytochrome C biogenesis protein
BME20236_RS12955	COG0697	spore germination
BME20236_RS12960	COG0187	DNA topoisomerase II activity
BME20236_RS12990	COG1960	acyl-CoA dehydrogenase activity
BME20236_RS13000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BME20236_RS13010	COG0758	DNA mediated transformation
BME20236_RS13020	COG1754	DNA topoisomerase type I activity
BME20236_RS13020	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BME20236_RS13025	COG0557	exoribonuclease II activity
BME20236_RS13070	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
BME20236_RS13110	COG2176	DNA-directed DNA polymerase activity
BME20236_RS13130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BME20236_RS13160	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
BME20236_RS13170	COG1414	Transcriptional regulator
BME20236_RS13185	COG0583	DNA-binding transcription factor activity
BME20236_RS13190	COG2267	carboxylic ester hydrolase activity
BME20236_RS13195	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
BME20236_RS13200	COG3485	protocatechuate 3,4-dioxygenase
BME20236_RS13205	COG3485	protocatechuate 3,4-dioxygenase
BME20236_RS13210	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BME20236_RS13215	COG0683	leucine binding
BME20236_RS13235	COG3842	ATPase activity
BME20236_RS13240	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
BME20236_RS13255	COG1175	transmembrane transport
BME20236_RS13260	COG0395	ABC-type sugar transport system, permease component
BME20236_RS13270	COG3273	potassium ion transport
BME20236_RS13270	COG0471	metal ion transport
BME20236_RS13280	COG2252	PERMEase
BME20236_RS13300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
BME20236_RS13325	COG4607	ABC-type enterochelin transport system periplasmic component
BME20236_RS13330	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BME20236_RS13335	COG4605	iron ion homeostasis
BME20236_RS13340	COG4604	ABC transporter, ATP-binding protein
BME20236_RS13355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BME20236_RS13360	COG0765	amino acid transport
BME20236_RS13365	COG1126	abc transporter atp-binding protein
BME20236_RS13370	COG0248	Ppx GppA phosphatase
BME20236_RS13380	COG0477	Major facilitator Superfamily
BME20236_RS13390	COG3842	ATPase activity
BME20236_RS13395	COG0395	ABC-type sugar transport system, permease component
BME20236_RS13400	COG1175	transmembrane transport
BME20236_RS13405	COG1653	transport
BME20236_RS13435	COG1840	ABC-type Fe3 transport system, periplasmic component
BME20236_RS13445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BME20236_RS13460	COG2132	Multicopper oxidase
BME20236_RS13470	COG0477	Major facilitator Superfamily
BME20236_RS13480	COG0450	alkyl hydroperoxide reductase
BME20236_RS13495	COG0673	inositol 2-dehydrogenase activity
BME20236_RS13505	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
BME20236_RS13510	COG3962	Belongs to the TPP enzyme family
BME20236_RS13520	COG3718	enzyme involved in inositol metabolism
BME20236_RS13530	COG3842	ATPase activity
BME20236_RS13540	COG1840	ABC-type Fe3 transport system, periplasmic component
BME20236_RS13550	COG1522	sequence-specific DNA binding
BME20236_RS13560	COG0509	glycine decarboxylation via glycine cleavage system
BME20236_RS13565	COG0404	The glycine cleavage system catalyzes the degradation of glycine
BME20236_RS13615	COG4176	ABC-type proline glycine betaine transport system permease component
BME20236_RS13640	COG1737	Transcriptional regulator
BME20236_RS13665	COG0395	ABC-type sugar transport system, permease component
BME20236_RS13670	COG0251	oxidation-reduction process
BME20236_RS13680	COG1120	ATPase activity
BME20236_RS13685	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BME20236_RS13710	COG1846	Transcriptional regulator
BME20236_RS13745	COG0174	glutamine synthetase
BME20236_RS13755	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BME20236_RS13795	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BME20236_RS13800	COG0363	glucosamine-6-phosphate deaminase activity
BME20236_RS13805	COG0129	dihydroxy-acid dehydratase activity
BME20236_RS13820	COG4172	Belongs to the ABC transporter superfamily
BME20236_RS13830	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BME20236_RS13840	COG0747	negative chemotaxis
BME20236_RS13850	COG0288	reversible hydration of carbon dioxide
BME20236_RS13875	COG1250	3-hydroxyacyl-CoA dehydrogenase
BME20236_RS13875	COG1024	Enoyl-CoA hydratase
BME20236_RS13880	COG0183	Belongs to the thiolase family
BME20236_RS13885	COG1960	acyl-CoA dehydrogenase activity
BME20236_RS13920	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BME20236_RS13925	COG0601	transmembrane transport
BME20236_RS13930	COG0747	negative chemotaxis
BME20236_RS13945	COG4208	sulfate ABC transporter
BME20236_RS13950	COG1176	ABC-type spermidine putrescine transport system, permease component I
BME20236_RS13955	COG3842	ATPase activity
BME20236_RS13965	COG0246	Mannitol dehydrogenase
BME20236_RS13975	COG1904	glucuronate isomerase
BME20236_RS13980	COG1802	Transcriptional regulator
BME20236_RS14000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BME20236_RS14010	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BME20236_RS14015	COG1993	acr, cog1993
BME20236_RS14020	COG0789	Transcriptional regulator
BME20236_RS14030	COG0730	response to heat
BME20236_RS14045	COG1201	RNA secondary structure unwinding
BME20236_RS14115	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
BME20236_RS14125	COG3586	endonuclease activity
BME20236_RS14135	COG3293	Transposase
BME20236_RS14160	COG1088	dTDP-glucose 4,6-dehydratase activity
BME20236_RS14170	COG0277	FAD linked oxidase domain protein
BME20236_RS14175	COG0546	phosphoglycolate phosphatase activity
BME20236_RS14175	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
BME20236_RS14180	COG1349	DNA-binding transcription factor activity
BME20236_RS14190	COG1172	Belongs to the binding-protein-dependent transport system permease family
BME20236_RS14195	COG1129	ABC transporter
BME20236_RS14225	COG1349	DNA-binding transcription factor activity
BME20236_RS14260	COG1217	gtp-binding protein TYPA
BME20236_RS14265	COG2239	Acts as a magnesium transporter
BME20236_RS14270	COG0339	signal peptide processing
BME20236_RS14300	COG1764	response to oxidative stress
BME20236_RS14305	COG1846	Transcriptional regulator
BME20236_RS14310	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BME20236_RS14320	COG2169	Transcriptional regulator
BME20236_RS14320	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BME20236_RS14365	COG2423	ornithine cyclodeaminase activity
BME20236_RS14370	COG0010	Belongs to the arginase family
BME20236_RS14380	COG1902	pentaerythritol trinitrate reductase activity
BME20236_RS14385	COG0640	Transcriptional regulator
BME20236_RS14390	COG2183	response to ionizing radiation
BME20236_RS14395	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BME20236_RS14405	COG5383	Protein conserved in bacteria
BME20236_RS14405	COG5383	Protein conserved in bacteria
BME20236_RS14410	COG1012	belongs to the aldehyde dehydrogenase family
BME20236_RS14425	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
BME20236_RS14430	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BME20236_RS14435	COG2188	Transcriptional regulator
BME20236_RS14445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BME20236_RS14460	COG0243	molybdopterin cofactor binding
BME20236_RS14470	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
BME20236_RS14475	COG1522	sequence-specific DNA binding
BME20236_RS14505	COG0402	S-adenosylhomocysteine deaminase activity
BME20236_RS14535	COG4214	carbohydrate transport
BME20236_RS14540	COG1129	ABC transporter
BME20236_RS14545	COG4213	ABC transporter substrate-binding protein
BME20236_RS14550	COG4213	ABC transporter substrate-binding protein
BME20236_RS14555	COG0800	Aldolase
BME20236_RS14560	COG3734	2-keto-3-deoxy-galactonokinase
BME20236_RS14565	COG0129	dihydroxy-acid dehydratase activity
BME20236_RS14580	COG1172	Belongs to the binding-protein-dependent transport system permease family
BME20236_RS14585	COG2186	Transcriptional regulator
BME20236_RS14590	COG0028	Belongs to the TPP enzyme family
BME20236_RS14605	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BME20236_RS14670	COG2011	ABC-type metal ion transport system permease component
BME20236_RS14745	COG5001	Diguanylate cyclase
BME20236_RS14750	COG1028	Short-chain dehydrogenase reductase Sdr
BME20236_RS14755	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BME20236_RS14760	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BME20236_RS14765	COG1609	Transcriptional regulator
BME20236_RS14785	COG0523	cobalamin synthesis protein
BME20236_RS14795	COG0400	carboxylic ester hydrolase activity
BME20236_RS14800	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BME20236_RS14810	COG0251	oxidation-reduction process
BME20236_RS14815	COG1172	Belongs to the binding-protein-dependent transport system permease family
BME20236_RS14825	COG1129	ABC transporter
BME20236_RS14830	COG1129	ABC transporter
BME20236_RS14835	COG1879	ABC-type sugar transport system periplasmic component
BME20236_RS14875	COG3706	GGDEF domain
BME20236_RS14880	COG0579	oxidoreductase
BME20236_RS14885	COG2176	DNA-directed DNA polymerase activity
BME20236_RS14890	COG0154	amidase activity
BME20236_RS14895	COG4608	Belongs to the ABC transporter superfamily
BME20236_RS14900	COG0444	Belongs to the ABC transporter superfamily
BME20236_RS14905	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BME20236_RS14925	COG1012	belongs to the aldehyde dehydrogenase family
BME20236_RS14930	COG1802	Transcriptional regulator
BME20236_RS14935	COG2814	Major facilitator Superfamily
BME20236_RS14950	COG0251	oxidation-reduction process
BME20236_RS14970	COG0218	Necessary for normal cell division and for the maintenance of normal septation
BME20236_RS15020	COG0242	peptide deformylase activity
BME20236_RS15035	COG2827	Endonuclease containing a URI domain
BME20236_RS15065	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BME20236_RS15085	COG0837	glucose binding
BME20236_RS15090	COG1132	(ABC) transporter
BME20236_RS15095	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BME20236_RS15110	COG1228	amidohydrolase
BME20236_RS15115	COG0778	Nitroreductase
BME20236_RS15140	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
BME20236_RS15150	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
BME20236_RS15155	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
BME20236_RS15160	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
BME20236_RS15210	COG0277	FAD linked oxidase domain protein
BME20236_RS15220	COG3395	kinase activity
BME20236_RS15225	COG0235	Class ii aldolase
BME20236_RS15250	COG1176	ABC-type spermidine putrescine transport system, permease component I
BME20236_RS15265	COG0154	amidase activity
BME20236_RS15275	COG4608	Belongs to the ABC transporter superfamily
BME20236_RS15280	COG0444	Belongs to the ABC transporter superfamily
BME20236_RS15290	COG0601	transmembrane transport
BME20236_RS15295	COG0747	negative chemotaxis
BME20236_RS15310	COG0444	Belongs to the ABC transporter superfamily
BME20236_RS15325	COG0747	negative chemotaxis
BME20236_RS15350	COG1250	3-hydroxyacyl-CoA dehydrogenase
BME20236_RS15355	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
BME20236_RS15375	COG0601	transmembrane transport
BME20236_RS15380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BME20236_RS15380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BME20236_RS15385	COG0444	Belongs to the ABC transporter superfamily
BME20236_RS15390	COG4608	Belongs to the ABC transporter superfamily
BME20236_RS15395	COG1804	L-carnitine dehydratase bile acid-inducible protein F
BME20236_RS15455	COG2971	BadF BadG BcrA BcrD
BME20236_RS15460	COG1959	2 iron, 2 sulfur cluster binding
BME20236_RS15465	COG0523	cobalamin synthesis protein
BME20236_RS15480	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BME20236_RS15485	COG0735	belongs to the Fur family
BME20236_RS15520	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BME20236_RS15525	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BME20236_RS15535	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BME20236_RS15585	COG1360	Flagellar Motor Protein
BME20236_RS15600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BME20236_RS15620	COG4213	ABC transporter substrate-binding protein
BME20236_RS15625	COG1129	ABC transporter
BME20236_RS15630	COG4214	carbohydrate transport
BME20236_RS15650	COG3971	2-oxopent-4-enoate hydratase activity
BME20236_RS15655	COG0179	Fumarylacetoacetate (FAA) hydrolase
BME20236_RS15675	COG1846	Transcriptional regulator
BME20236_RS15680	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
BME20236_RS15685	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BME20236_RS15700	COG5441	Belongs to the UPF0261 family
BME20236_RS15710	COG0531	amino acid
BME20236_RS15715	COG1012	belongs to the aldehyde dehydrogenase family
BME20236_RS15720	COG1228	amidohydrolase
BME20236_RS15735	COG1129	ABC transporter
BME20236_RS15755	COG2188	Transcriptional regulator
BME20236_RS15760	COG1653	transport
BME20236_RS15765	COG3833	ABC-type maltose transport systems, permease component
BME20236_RS15770	COG1175	transmembrane transport
BME20236_RS15775	COG3842	ATPase activity
BME20236_RS15795	COG1116	anion transmembrane transporter activity
BME20236_RS15810	COG4206	TonB-dependent receptor
BME20236_RS15835	COG0411	ABC transporter
BME20236_RS15850	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BME20236_RS15860	COG1192	Involved in chromosome partitioning
BME20236_RS15865	COG1475	DNA binding