locus-tag	class	description
F7D16_RS00025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F7D16_RS00030	COG4172	Belongs to the ABC transporter superfamily
F7D16_RS00035	COG4239	(ABC) transporter, permease
F7D16_RS00040	COG4174	ABC transporter (Permease)
F7D16_RS00050	COG4166	transmembrane transport
F7D16_RS00070	COG0683	leucine binding
F7D16_RS00095	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F7D16_RS00100	COG1960	acyl-CoA dehydrogenase activity
F7D16_RS00145	COG0539	negative regulation of cytoplasmic translation
F7D16_RS00150	COG2855	membrane
F7D16_RS00155	COG0583	DNA-binding transcription factor activity
F7D16_RS00165	COG2951	lytic endotransglycosylase activity
F7D16_RS00180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
F7D16_RS00195	COG2816	NAD+ diphosphatase activity
F7D16_RS00200	COG0077	Prephenate dehydratase
F7D16_RS00200	COG1605	Chorismate mutase
F7D16_RS00210	COG3474	cytochrome
F7D16_RS00220	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F7D16_RS00225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F7D16_RS00230	COG1845	cytochrome c oxidase, subunit III
F7D16_RS00235	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
F7D16_RS00295	COG0346	lactoylglutathione lyase activity
F7D16_RS00300	COG0489	protein tyrosine kinase activity
F7D16_RS00305	COG0033	Phosphoglucomutase
F7D16_RS00320	COG1073	alpha beta
F7D16_RS00325	COG1072	(Pantothenic acid kinase))
F7D16_RS00355	COG1272	protein, Hemolysin III
F7D16_RS00360	COG0587	DNA-directed DNA polymerase activity
F7D16_RS00425	COG3339	Conserved Protein
F7D16_RS00435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F7D16_RS00440	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
F7D16_RS00465	COG0670	Belongs to the BI1 family
F7D16_RS00485	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
F7D16_RS00495	COG4133	protoheme IX ABC transporter activity
F7D16_RS00500	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F7D16_RS00505	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
F7D16_RS00515	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F7D16_RS00565	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
F7D16_RS00575	COG4208	sulfate ABC transporter
F7D16_RS00580	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
F7D16_RS00585	COG3459	Glycosyltransferase 36 associated
F7D16_RS00595	COG0384	phenazine biosynthesis protein PhzF
F7D16_RS00600	COG2226	methyltransferase
F7D16_RS00610	COG1028	Short-chain dehydrogenase reductase Sdr
F7D16_RS00615	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F7D16_RS00630	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F7D16_RS00635	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
F7D16_RS00645	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F7D16_RS00645	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
F7D16_RS00690	COG1643	Atp-dependent helicase
F7D16_RS00715	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
F7D16_RS00725	COG1388	LysM domain
F7D16_RS00725	COG1376	ErfK ybiS ycfS ynhG family protein
F7D16_RS00730	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
F7D16_RS00740	COG0180	Tryptophanyl-tRNA synthetase
F7D16_RS00745	COG0728	peptidoglycan biosynthetic process
F7D16_RS00755	COG0280	phosphate acetyltransferase
F7D16_RS00755	COG0281	malic enzyme
F7D16_RS00765	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
F7D16_RS00780	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F7D16_RS00805	COG0616	signal peptide processing
F7D16_RS00815	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
F7D16_RS00820	COG1137	ATPase activity
F7D16_RS00825	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
F7D16_RS00840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
F7D16_RS00850	COG0071	Belongs to the small heat shock protein (HSP20) family
F7D16_RS00880	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F7D16_RS00885	COG2860	membrane
F7D16_RS00920	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
F7D16_RS00925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F7D16_RS00930	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
F7D16_RS00940	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
F7D16_RS00940	COG1648	precorrin-2 dehydrogenase activity
F7D16_RS00950	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
F7D16_RS00955	COG0175	sulfate reduction
F7D16_RS00970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F7D16_RS00995	COG2197	response regulator
F7D16_RS01000	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F7D16_RS01020	COG1218	3'(2'),5'-bisphosphate nucleotidase
F7D16_RS01035	COG2197	response regulator
F7D16_RS01060	COG1012	belongs to the aldehyde dehydrogenase family
F7D16_RS01090	COG1012	belongs to the aldehyde dehydrogenase family
F7D16_RS01100	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
F7D16_RS01105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
F7D16_RS01130	COG0351	phosphomethylpyrimidine kinase
F7D16_RS01135	COG5001	Diguanylate cyclase
F7D16_RS01155	COG1174	glycine betaine transport
F7D16_RS01160	COG1125	glycine betaine transport
F7D16_RS01165	COG1174	glycine betaine transport
F7D16_RS01170	COG1732	Glycine betaine
F7D16_RS01180	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
F7D16_RS01195	COG0446	pyridine nucleotide-disulphide oxidoreductase
F7D16_RS01195	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F7D16_RS01210	COG1414	Transcriptional regulator
F7D16_RS01220	COG1175	transmembrane transport
F7D16_RS01225	COG0395	ABC-type sugar transport system, permease component
F7D16_RS01230	COG3842	ATPase activity
F7D16_RS01235	COG4948	Mandelate Racemase Muconate Lactonizing
F7D16_RS01240	COG3254	rhamnose metabolic process
F7D16_RS01250	COG1028	Short-chain dehydrogenase reductase Sdr
F7D16_RS01260	COG4948	Mandelate Racemase Muconate Lactonizing
F7D16_RS01285	COG0582	viral genome integration into host DNA
F7D16_RS01440	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
F7D16_RS01455	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
F7D16_RS01465	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
F7D16_RS01495	COG3617	BRO family, N-terminal domain
F7D16_RS01510	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F7D16_RS01550	COG0829	nickel cation binding
F7D16_RS01565	COG0804	urea catabolic process
F7D16_RS01575	COG0830	nickel cation binding
F7D16_RS01590	COG4191	Histidine kinase
F7D16_RS01600	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F7D16_RS01605	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F7D16_RS01625	COG0494	nUDIX hydrolase
F7D16_RS01635	COG0493	'glutamate synthase
F7D16_RS01665	COG0318	PFAM AMP-dependent synthetase and ligase
F7D16_RS01705	COG2326	polyphosphate kinase activity
F7D16_RS01710	COG5002	protein histidine kinase activity
F7D16_RS01725	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F7D16_RS01735	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
F7D16_RS01755	COG0717	Belongs to the dCTP deaminase family
F7D16_RS01775	COG0534	Mate efflux family protein
F7D16_RS01805	COG2198	Histidine kinase
F7D16_RS01805	COG0784	Response regulator, receiver
F7D16_RS01805	COG2205	protein histidine kinase activity
F7D16_RS01815	COG0156	8-amino-7-oxononanoate synthase activity
F7D16_RS01840	COG0583	DNA-binding transcription factor activity
F7D16_RS01845	COG1380	Effector of murein hydrolase LrgA
F7D16_RS01850	COG1346	cytolysis
F7D16_RS01890	COG0019	diaminopimelate decarboxylase activity
F7D16_RS01915	COG5342	invasion associated locus B
F7D16_RS01935	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
F7D16_RS01940	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
F7D16_RS01945	COG3257	ureidoglycine aminohydrolase activity
F7D16_RS01950	COG3195	allantoin biosynthetic process
F7D16_RS01950	COG3648	Uricase
F7D16_RS01960	COG2080	2 iron, 2 sulfur cluster binding
F7D16_RS01965	COG1529	Aldehyde oxidase and xanthine dehydrogenase
F7D16_RS01975	COG0583	DNA-binding transcription factor activity
F7D16_RS01985	COG0402	S-adenosylhomocysteine deaminase activity
F7D16_RS02050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
F7D16_RS02050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F7D16_RS02060	COG2169	Transcriptional regulator
F7D16_RS02060	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F7D16_RS02065	COG1393	Belongs to the ArsC family
F7D16_RS02075	COG0477	Major facilitator Superfamily
F7D16_RS02080	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
F7D16_RS02105	COG3773	Cell wall hydrolase
F7D16_RS02125	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
F7D16_RS02165	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
F7D16_RS02180	COG0616	signal peptide processing
F7D16_RS02180	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
F7D16_RS02200	COG0142	geranyltranstransferase activity
F7D16_RS02215	COG0751	glycine-tRNA ligase activity
F7D16_RS02220	COG0009	L-threonylcarbamoyladenylate synthase
F7D16_RS02250	COG1960	acyl-CoA dehydrogenase activity
F7D16_RS02265	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F7D16_RS02280	COG0484	heat shock protein binding
F7D16_RS02285	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F7D16_RS02300	COG1278	Cold shock
F7D16_RS02325	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F7D16_RS02325	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
F7D16_RS02330	COG0123	including yeast histone deacetylase and acetoin utilization protein
F7D16_RS02335	COG1722	exodeoxyribonuclease VII activity
F7D16_RS02355	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
F7D16_RS02360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
F7D16_RS02380	COG5265	(ABC) transporter
F7D16_RS02390	COG1183	phosphatidylcholine synthase activity
F7D16_RS02395	COG1028	Short-chain dehydrogenase reductase Sdr
F7D16_RS02400	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
F7D16_RS02420	COG0305	Participates in initiation and elongation during chromosome replication
F7D16_RS02425	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
F7D16_RS02455	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
F7D16_RS02480	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F7D16_RS02490	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
F7D16_RS02495	COG1561	YicC-like family, N-terminal region
F7D16_RS02500	COG0194	GDP metabolic process
F7D16_RS02505	COG0312	modulator of DNA gyrase
F7D16_RS02515	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
F7D16_RS02520	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
F7D16_RS02555	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
F7D16_RS02570	COG0678	peroxiredoxin activity
F7D16_RS02570	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F7D16_RS02590	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
F7D16_RS02595	COG0612	Peptidase, M16
F7D16_RS02610	COG4943	cyclic-guanylate-specific phosphodiesterase activity
F7D16_RS02620	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F7D16_RS02630	COG2189	Belongs to the N(4) N(6)-methyltransferase family
F7D16_RS02640	COG1194	a g-specific adenine glycosylase
F7D16_RS02660	COG1196	nuclear chromosome segregation
F7D16_RS02675	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
F7D16_RS02675	COG0574	Belongs to the PEP-utilizing enzyme family
F7D16_RS02700	COG1268	BioY protein
F7D16_RS02710	COG2351	hydroxyisourate hydrolase activity
F7D16_RS02725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F7D16_RS02785	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
F7D16_RS02820	COG2801	Transposase and inactivated derivatives
F7D16_RS02825	COG2801	Transposase and inactivated derivatives
F7D16_RS02850	COG0662	Cupin 2, conserved barrel domain protein
F7D16_RS02850	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
F7D16_RS02855	COG2942	2-epimerase
F7D16_RS02860	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
F7D16_RS02860	COG0438	transferase activity, transferring glycosyl groups
F7D16_RS02880	COG1172	Belongs to the binding-protein-dependent transport system permease family
F7D16_RS02885	COG1879	ABC-type sugar transport system periplasmic component
F7D16_RS02895	COG0673	inositol 2-dehydrogenase activity
F7D16_RS02905	COG1070	Carbohydrate kinase
F7D16_RS02950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
F7D16_RS02970	COG2186	Transcriptional regulator
F7D16_RS02975	COG2807	transmembrane transport
F7D16_RS02985	COG0433	COG0433 Predicted ATPase
F7D16_RS02990	COG1376	ErfK ybiS ycfS ynhG family protein
F7D16_RS03005	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
F7D16_RS03020	COG4957	zinc ion binding
F7D16_RS03030	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
F7D16_RS03040	COG0154	amidase activity
F7D16_RS03045	COG2166	iron-sulfur cluster assembly
F7D16_RS03055	COG2205	protein histidine kinase activity
F7D16_RS03085	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F7D16_RS03100	COG4695	Portal protein
F7D16_RS03205	COG4235	cytochrome complex assembly
F7D16_RS03215	COG1138	Cytochrome C-type biogenesis protein
F7D16_RS03220	COG3088	subunit of a heme lyase
F7D16_RS03225	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F7D16_RS03230	COG0745	RESPONSE REGULATOR receiver
F7D16_RS03240	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
F7D16_RS03250	COG2202	Pas domain
F7D16_RS03250	COG2205	protein histidine kinase activity
F7D16_RS03255	COG0308	aminopeptidase N
F7D16_RS03270	COG1573	uracil-dna glycosylase
F7D16_RS03285	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
F7D16_RS03290	COG0625	glutathione transferase activity
F7D16_RS03325	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F7D16_RS03330	COG4974	Belongs to the 'phage' integrase family
F7D16_RS03360	COG0261	This protein binds to 23S rRNA in the presence of protein L20
F7D16_RS03360	COG3743	rRNA binding
F7D16_RS03365	COG0741	lytic transglycosylase activity
F7D16_RS03405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
F7D16_RS03410	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F7D16_RS03415	COG2223	nitrite transmembrane transporter activity
F7D16_RS03420	COG2207	Transcriptional regulator
F7D16_RS03435	COG0681	Belongs to the peptidase S26 family
F7D16_RS03460	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
F7D16_RS03470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F7D16_RS03490	COG0494	nUDIX hydrolase
F7D16_RS03520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F7D16_RS03530	COG0739	heme binding
F7D16_RS03540	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
F7D16_RS03545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F7D16_RS03550	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
F7D16_RS03585	COG0488	(ABC) transporter
F7D16_RS03605	COG0314	molybdopterin synthase activity
F7D16_RS03610	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
F7D16_RS03615	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
F7D16_RS03630	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F7D16_RS03650	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
F7D16_RS03660	COG0243	molybdopterin cofactor binding
F7D16_RS03670	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
F7D16_RS03685	COG0628	permease
F7D16_RS03710	COG1028	Short-chain dehydrogenase reductase Sdr
F7D16_RS03830	COG0626	cystathionine gamma-synthase activity
F7D16_RS03840	COG0671	phosphoesterase, PA-phosphatase related
F7D16_RS03845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F7D16_RS03855	COG4597	amino acid ABC transporter
F7D16_RS03865	COG1126	abc transporter atp-binding protein
F7D16_RS03880	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
F7D16_RS03890	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
F7D16_RS03910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F7D16_RS03925	COG0113	porphobilinogen synthase activity
F7D16_RS03945	COG2989	Protein conserved in bacteria
F7D16_RS03960	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F7D16_RS03960	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
F7D16_RS03980	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
F7D16_RS03985	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F7D16_RS04075	COG0010	Belongs to the arginase family
F7D16_RS04160	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
F7D16_RS04180	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
F7D16_RS04185	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
F7D16_RS04225	COG1007	ATP synthesis coupled electron transport
F7D16_RS04240	COG0346	lactoylglutathione lyase activity
F7D16_RS04300	COG0483	inositol monophosphate 1-phosphatase activity
F7D16_RS04305	COG2814	Major facilitator Superfamily
F7D16_RS04345	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
F7D16_RS04375	COG2514	catechol 2,3-dioxygenase activity
F7D16_RS04380	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F7D16_RS04400	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F7D16_RS04405	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
F7D16_RS04410	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
F7D16_RS04430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F7D16_RS04435	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
F7D16_RS04440	COG3454	Phosphonate metabolism
F7D16_RS04445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
F7D16_RS04450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F7D16_RS04455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
F7D16_RS04480	COG1522	sequence-specific DNA binding
F7D16_RS04485	COG1573	uracil-dna glycosylase
F7D16_RS04515	COG0316	Belongs to the HesB IscA family
F7D16_RS04535	COG1472	Belongs to the glycosyl hydrolase 3 family
F7D16_RS04540	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
F7D16_RS04545	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
F7D16_RS04555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
F7D16_RS04560	COG0805	protein transport
F7D16_RS04575	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F7D16_RS04595	COG1862	Preprotein translocase
F7D16_RS04645	COG0544	peptidyl-prolyl cis-trans isomerase activity
F7D16_RS04665	COG4765	Protein conserved in bacteria
F7D16_RS04675	COG0439	Biotin carboxylase
F7D16_RS04680	COG0511	ligase activity, forming carbon-carbon bonds
F7D16_RS04695	COG0501	Belongs to the peptidase M48B family
F7D16_RS04705	COG0436	Aminotransferase
F7D16_RS04710	COG1530	ribonuclease E activity
F7D16_RS04720	COG0860	N-Acetylmuramoyl-L-alanine amidase
F7D16_RS04725	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
F7D16_RS04750	COG2833	Protein of unknown function (DUF455)
F7D16_RS04755	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
F7D16_RS04770	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
F7D16_RS04780	COG2945	thiolester hydrolase activity
F7D16_RS04790	COG0719	Fe-S assembly protein
F7D16_RS04795	COG0396	ATPase activity
F7D16_RS04800	COG0719	Fe-S assembly protein
F7D16_RS04805	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
F7D16_RS04810	COG2151	metal-sulfur cluster biosynthetic enzyme
F7D16_RS04825	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
F7D16_RS04830	COG0513	Belongs to the DEAD box helicase family
F7D16_RS04835	COG0316	Belongs to the HesB IscA family
F7D16_RS04855	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
F7D16_RS04875	COG0525	valine-tRNA ligase activity
F7D16_RS04890	COG2084	Dehydrogenase
F7D16_RS04945	COG2989	Protein conserved in bacteria
F7D16_RS05080	COG1393	Belongs to the ArsC family
F7D16_RS05110	COG0084	hydrolase, TatD family'
F7D16_RS05120	COG1132	(ABC) transporter
F7D16_RS05145	COG0174	glutamine synthetase
F7D16_RS05150	COG0347	Belongs to the P(II) protein family
F7D16_RS05155	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
F7D16_RS05155	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
F7D16_RS05165	COG0546	phosphoglycolate phosphatase activity
F7D16_RS05170	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
F7D16_RS05185	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
F7D16_RS05190	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
F7D16_RS05200	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
F7D16_RS05200	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F7D16_RS05210	COG0280	phosphate acetyltransferase
F7D16_RS05210	COG0281	malic enzyme
F7D16_RS05220	COG4948	Mandelate Racemase Muconate Lactonizing
F7D16_RS05225	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
F7D16_RS05235	COG1127	ABC transporter
F7D16_RS05260	COG0633	Ferredoxin
F7D16_RS05265	COG0492	ferredoxin-NADP+ reductase activity
F7D16_RS05280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
F7D16_RS05290	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
F7D16_RS05305	COG3106	COG3106 Predicted ATPase
F7D16_RS05330	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
F7D16_RS05340	COG0668	transmembrane transport
F7D16_RS05345	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
F7D16_RS05385	COG1058	Belongs to the CinA family
F7D16_RS05385	COG1546	Belongs to the CinA family
F7D16_RS05405	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
F7D16_RS05410	COG0513	Belongs to the DEAD box helicase family
F7D16_RS05415	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
F7D16_RS05420	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
F7D16_RS05425	COG2897	thiosulfate sulfurtransferase activity
F7D16_RS05445	COG0427	acetyl-CoA hydrolase
F7D16_RS05450	COG2814	Major facilitator Superfamily
F7D16_RS05455	COG1566	PFAM secretion protein HlyD family protein
F7D16_RS05465	COG0006	proline dipeptidase activity
F7D16_RS05470	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
F7D16_RS05485	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F7D16_RS05495	COG3956	TIGRFAM MazG family protein
F7D16_RS05500	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F7D16_RS05545	COG1752	Esterase of the alpha-beta hydrolase superfamily
F7D16_RS05600	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
F7D16_RS05615	COG3617	BRO family, N-terminal domain
F7D16_RS05625	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F7D16_RS05630	COG1960	acyl-CoA dehydrogenase activity
F7D16_RS05635	COG0583	DNA-binding transcription factor activity
F7D16_RS05640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F7D16_RS05645	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
F7D16_RS05650	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F7D16_RS05690	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
F7D16_RS05695	COG2095	MarC family integral membrane protein
F7D16_RS05705	COG2188	Transcriptional regulator
F7D16_RS05735	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
F7D16_RS05745	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
F7D16_RS05760	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
F7D16_RS05780	COG0569	domain protein
F7D16_RS05785	COG2204	response regulator
F7D16_RS05790	COG5000	phosphorelay sensor kinase activity
F7D16_RS05795	COG2204	response regulator
F7D16_RS05800	COG3852	Histidine kinase
F7D16_RS05815	COG1546	Belongs to the CinA family
F7D16_RS05815	COG1058	Belongs to the CinA family
F7D16_RS05825	COG2867	negative regulation of translational initiation
F7D16_RS05840	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
F7D16_RS05845	COG0508	dehydrogenase complex catalyzes the overall conversion of
F7D16_RS05850	COG0508	dehydrogenase complex catalyzes the overall conversion of
F7D16_RS05850	COG0022	dehydrogenase e1 component
F7D16_RS05855	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F7D16_RS05860	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
F7D16_RS05905	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F7D16_RS05925	COG0303	'Molybdopterin
F7D16_RS05935	COG0658	competence protein
F7D16_RS05935	COG2333	competence protein COMEC
F7D16_RS05945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F7D16_RS05950	COG0372	Belongs to the citrate synthase family
F7D16_RS05955	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
F7D16_RS05980	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F7D16_RS05985	COG0750	zinc metalloprotease
F7D16_RS06005	COG0528	UMP kinase activity
F7D16_RS06035	COG0584	glycerophosphoryl diester phosphodiesterase
F7D16_RS06045	COG0537	adenosine 5'-monophosphoramidase activity
F7D16_RS06065	COG1686	Belongs to the peptidase S11 family
F7D16_RS06080	COG1760	l-serine dehydratase
F7D16_RS06125	COG3800	Transcriptional regulator
F7D16_RS06125	COG1396	sequence-specific DNA binding
F7D16_RS06130	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
F7D16_RS06135	COG4770	biotin carboxylase activity
F7D16_RS06140	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F7D16_RS06140	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
F7D16_RS06155	COG2358	TRAP transporter, solute receptor (TAXI family
F7D16_RS06165	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
F7D16_RS06170	COG0693	protein deglycase activity
F7D16_RS06180	COG0538	isocitrate dehydrogenase activity
F7D16_RS06185	COG1785	Belongs to the alkaline phosphatase family
F7D16_RS06200	COG2885	chlorophyll binding
F7D16_RS06210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
F7D16_RS06215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
F7D16_RS06265	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
F7D16_RS06330	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
F7D16_RS06420	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
F7D16_RS06450	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
F7D16_RS06455	COG0516	GMP reductase activity
F7D16_RS06455	COG0517	IMP dehydrogenase activity
F7D16_RS06510	COG0346	lactoylglutathione lyase activity
F7D16_RS06525	COG1181	Belongs to the D-alanine--D-alanine ligase family
F7D16_RS06530	COG1494	fructose-1,6-bisphosphatase
F7D16_RS06540	COG0436	Aminotransferase
F7D16_RS06575	COG0024	Methionine aminopeptidase
F7D16_RS06630	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
F7D16_RS06640	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
F7D16_RS06750	COG0583	DNA-binding transcription factor activity
F7D16_RS06775	COG3264	Mechanosensitive ion channel
F7D16_RS06775	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
F7D16_RS06790	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F7D16_RS06790	COG4651	solute:proton antiporter activity
F7D16_RS06810	COG4208	sulfate ABC transporter
F7D16_RS06815	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
F7D16_RS06820	COG4150	thiosulfate binding
F7D16_RS06830	COG1253	flavin adenine dinucleotide binding
F7D16_RS06835	COG0586	Pfam SNARE associated Golgi protein
F7D16_RS06855	COG4154	Belongs to the RbsD FucU family
F7D16_RS06860	COG1028	Short-chain dehydrogenase reductase Sdr
F7D16_RS06870	COG1172	Belongs to the binding-protein-dependent transport system permease family
F7D16_RS06885	COG1120	ATPase activity
F7D16_RS06890	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F7D16_RS06905	COG0842	Transport permease protein
F7D16_RS06915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F7D16_RS06930	COG1649	PFAM Uncharacterised BCR, COG1649
F7D16_RS06945	COG0804	urea catabolic process
F7D16_RS06970	COG4413	Urea transporter
F7D16_RS06980	COG0310	cobalt ion transport
F7D16_RS07000	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F7D16_RS07000	COG3439	Domain of unknown function DUF302
F7D16_RS07020	COG0384	phenazine biosynthesis protein PhzF
F7D16_RS07045	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F7D16_RS07065	COG3158	transport of potassium into the cell
F7D16_RS07080	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
F7D16_RS07085	COG0440	acetolactate synthase activity
F7D16_RS07090	COG0028	Belongs to the TPP enzyme family
F7D16_RS07105	COG0560	Phosphoserine phosphatase
F7D16_RS07125	COG0330	HflC and HflK could
F7D16_RS07160	COG2814	Major facilitator Superfamily
F7D16_RS07190	COG0277	FAD linked oxidase domain protein
F7D16_RS07205	COG0210	DNA helicase
F7D16_RS07220	COG1999	signal sequence binding
F7D16_RS07230	COG0006	proline dipeptidase activity
F7D16_RS07250	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
F7D16_RS07265	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
F7D16_RS07270	COG0849	cell division
F7D16_RS07275	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
F7D16_RS07280	COG1181	Belongs to the D-alanine--D-alanine ligase family
F7D16_RS07320	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
F7D16_RS07345	COG1914	H( )-stimulated, divalent metal cation uptake system
F7D16_RS07360	COG3023	N-Acetylmuramoyl-L-alanine amidase
F7D16_RS07365	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
F7D16_RS07395	COG0640	Transcriptional regulator
F7D16_RS07405	COG0477	Major facilitator Superfamily
F7D16_RS07430	COG2267	carboxylic ester hydrolase activity
F7D16_RS07455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
F7D16_RS07460	COG2824	Alkylphosphonate utilization operon protein PhnA
F7D16_RS07465	COG1335	isochorismatase
F7D16_RS07490	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
F7D16_RS07535	COG2968	Membrane
F7D16_RS07555	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F7D16_RS07565	COG0358	DNA primase activity
F7D16_RS07585	COG2321	neutral zinc metallopeptidase
F7D16_RS07600	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F7D16_RS07610	COG1136	(ABC) transporter
F7D16_RS07625	COG0625	glutathione transferase activity
F7D16_RS07630	COG0436	Aminotransferase
F7D16_RS07645	COG0583	DNA-binding transcription factor activity
F7D16_RS07650	COG0492	ferredoxin-NADP+ reductase activity
F7D16_RS07655	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
F7D16_RS07660	COG1522	sequence-specific DNA binding
F7D16_RS07710	COG0556	nucleotide-excision repair
F7D16_RS07715	COG0739	heme binding
F7D16_RS07715	COG0741	lytic transglycosylase activity
F7D16_RS07715	COG1196	nuclear chromosome segregation
F7D16_RS07720	COG1278	Cold shock
F7D16_RS07730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
F7D16_RS07750	COG1846	Transcriptional regulator
F7D16_RS07755	COG0745	RESPONSE REGULATOR receiver
F7D16_RS07760	COG2205	protein histidine kinase activity
F7D16_RS07765	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
F7D16_RS07800	COG1496	oxidoreductase activity
F7D16_RS07820	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
F7D16_RS07840	COG0012	GTP binding
F7D16_RS07845	COG2030	dehydratase
F7D16_RS07860	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
F7D16_RS07860	COG2857	Cytochrome c1
F7D16_RS07875	COG1132	(ABC) transporter
F7D16_RS07880	COG1132	(ABC) transporter
F7D16_RS07885	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
F7D16_RS07905	COG3153	acetyltransferase
F7D16_RS07920	COG0617	tRNA 3'-terminal CCA addition
F7D16_RS07935	COG0714	Associated with various cellular activities
F7D16_RS07960	COG0435	Glutathione S-transferase
F7D16_RS07965	COG3047	cAMP biosynthetic process
F7D16_RS07970	COG1051	belongs to the nudix hydrolase family
F7D16_RS07980	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
F7D16_RS07985	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
F7D16_RS07990	COG0512	Glutamine amidotransferase of anthranilate synthase
F7D16_RS07990	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
F7D16_RS08000	COG1522	sequence-specific DNA binding
F7D16_RS08030	COG4176	ABC-type proline glycine betaine transport system permease component
F7D16_RS08035	COG4175	Glycine betaine
F7D16_RS08040	COG4608	Belongs to the ABC transporter superfamily
F7D16_RS08045	COG0444	Belongs to the ABC transporter superfamily
F7D16_RS08050	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F7D16_RS08055	COG0601	transmembrane transport
F7D16_RS08165	COG2205	protein histidine kinase activity
F7D16_RS08185	COG1177	transmembrane transport
F7D16_RS08190	COG1176	ABC-type spermidine putrescine transport system, permease component I
F7D16_RS08195	COG3842	ATPase activity
F7D16_RS08215	COG2224	Isocitrate lyase
F7D16_RS08230	COG1028	Short-chain dehydrogenase reductase Sdr
F7D16_RS08235	COG1028	Short-chain dehydrogenase reductase Sdr
F7D16_RS08250	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F7D16_RS08265	COG1461	Dihydroxyacetone kinase
F7D16_RS08270	COG2376	Dihydroxyacetone kinase
F7D16_RS08275	COG1461	Dihydroxyacetone kinase
F7D16_RS08280	COG2376	Dihydroxyacetone kinase
F7D16_RS08290	COG1879	ABC-type sugar transport system periplasmic component
F7D16_RS08295	COG1172	Belongs to the binding-protein-dependent transport system permease family
F7D16_RS08300	COG1129	ABC transporter
F7D16_RS08355	COG1012	belongs to the aldehyde dehydrogenase family
F7D16_RS08380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
F7D16_RS08395	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F7D16_RS08400	COG0564	pseudouridine synthase activity
F7D16_RS08415	COG0735	belongs to the Fur family
F7D16_RS08435	COG0784	Response regulator, receiver
F7D16_RS08455	COG3920	Histidine kinase
F7D16_RS08485	COG0848	biopolymer transport protein
F7D16_RS08505	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F7D16_RS08515	COG1522	sequence-specific DNA binding
F7D16_RS08535	COG0477	Major facilitator Superfamily
F7D16_RS08555	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F7D16_RS08565	COG0385	Bile acid
F7D16_RS08575	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F7D16_RS08580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
F7D16_RS08595	COG2885	chlorophyll binding
F7D16_RS08615	COG0848	biopolymer transport protein
F7D16_RS08625	COG0824	Thioesterase
F7D16_RS08665	COG0483	inositol monophosphate 1-phosphatase activity
F7D16_RS08680	COG1132	(ABC) transporter
F7D16_RS08710	COG1253	flavin adenine dinucleotide binding
F7D16_RS08715	COG1692	metallophosphoesterase
F7D16_RS08765	COG1028	Short-chain dehydrogenase reductase Sdr
F7D16_RS08790	COG0604	alcohol dehydrogenase
F7D16_RS08790	COG3321	synthase
F7D16_RS08790	COG1028	Short-chain dehydrogenase reductase Sdr
F7D16_RS08820	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
F7D16_RS08825	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
F7D16_RS08835	COG0457	Tetratricopeptide repeat
F7D16_RS08840	COG0469	pyruvate kinase activity
F7D16_RS08855	COG3750	Belongs to the UPF0335 family
F7D16_RS08860	COG0488	(ABC) transporter
F7D16_RS08880	COG4143	(ABC) transporter
F7D16_RS08885	COG1178	ABC-type Fe3 transport system permease component
F7D16_RS08900	COG2258	MOSC domain
F7D16_RS08905	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
F7D16_RS08920	COG1329	Transcriptional regulator
F7D16_RS08925	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
F7D16_RS08965	COG0142	geranyltranstransferase activity
F7D16_RS08975	COG1028	Short-chain dehydrogenase reductase Sdr
F7D16_RS08980	COG0738	Major facilitator superfamily
F7D16_RS08985	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
F7D16_RS09025	COG3938	Belongs to the proline racemase family
F7D16_RS09100	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
F7D16_RS09110	COG5425	PFAM Usg family protein
F7D16_RS09130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
F7D16_RS09130	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
F7D16_RS09145	COG2270	Major facilitator Superfamily
F7D16_RS09160	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
F7D16_RS09165	COG1704	LemA family
F7D16_RS09175	COG0287	Prephenate dehydrogenase
F7D16_RS09175	COG1605	Chorismate mutase
F7D16_RS09180	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
F7D16_RS09195	COG0288	reversible hydration of carbon dioxide
F7D16_RS09240	COG0793	Belongs to the peptidase S41A family
F7D16_RS09260	COG0799	negative regulation of ribosome biogenesis
F7D16_RS09325	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
F7D16_RS09390	COG0739	heme binding
F7D16_RS09400	COG0542	response to heat
F7D16_RS09415	COG2890	protein-(glutamine-N5) methyltransferase activity
F7D16_RS09430	COG0527	aspartate kinase activity
F7D16_RS09460	COG1040	competence protein
F7D16_RS09465	COG2226	methyltransferase
F7D16_RS09520	COG2264	protein methyltransferase activity
F7D16_RS09525	COG0697	spore germination
F7D16_RS09530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
F7D16_RS09535	COG1674	ftsk spoiiie
F7D16_RS09540	COG0004	ammonium transporteR
F7D16_RS09545	COG1946	Acyl-CoA thioesterase
F7D16_RS09550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F7D16_RS09665	COG1280	lysine exporter protein (LysE YggA)
F7D16_RS09675	COG0508	dehydrogenase complex catalyzes the overall conversion of
F7D16_RS09685	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
F7D16_RS09705	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
F7D16_RS09725	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F7D16_RS09730	COG0552	protein localization to endoplasmic reticulum
F7D16_RS09755	COG0494	nUDIX hydrolase
F7D16_RS09765	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
F7D16_RS09770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F7D16_RS09795	COG2194	sulfuric ester hydrolase activity
F7D16_RS09825	COG0765	amino acid transport
F7D16_RS09830	COG0765	amino acid transport
F7D16_RS09850	COG1126	abc transporter atp-binding protein
F7D16_RS09860	COG1802	Transcriptional regulator
F7D16_RS09865	COG0252	asparaginase activity
F7D16_RS09890	COG1250	3-hydroxyacyl-CoA dehydrogenase
F7D16_RS09900	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
F7D16_RS09905	COG2086	electron transfer activity
F7D16_RS09915	COG0720	synthase
F7D16_RS09920	COG0602	queuosine metabolic process
F7D16_RS09935	COG0300	oxidoreductase activity
F7D16_RS09950	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
F7D16_RS09985	COG2226	methyltransferase
F7D16_RS09990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
F7D16_RS09995	COG0287	Prephenate dehydrogenase
F7D16_RS10025	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
F7D16_RS10045	COG2884	Cell division ATP-binding protein ftsE
F7D16_RS10060	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
F7D16_RS10065	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
F7D16_RS10130	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
F7D16_RS10145	COG0789	Transcriptional regulator
F7D16_RS10150	COG2217	Heavy metal translocating P-type atpase
F7D16_RS10195	COG4536	flavin adenine dinucleotide binding
F7D16_RS10215	COG4974	Belongs to the 'phage' integrase family
F7D16_RS10235	COG0523	cobalamin synthesis protein
F7D16_RS10240	COG1686	Belongs to the peptidase S11 family
F7D16_RS10255	COG1028	Short-chain dehydrogenase reductase Sdr
F7D16_RS10275	COG1028	Short-chain dehydrogenase reductase Sdr
F7D16_RS10285	COG1012	belongs to the aldehyde dehydrogenase family
F7D16_RS10290	COG1024	Enoyl-CoA hydratase
F7D16_RS10315	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
F7D16_RS10335	COG4120	Belongs to the binding-protein-dependent transport system permease family
F7D16_RS10340	COG0410	ABC transporter
F7D16_RS10375	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
F7D16_RS10380	COG1331	Highly conserved protein containing a thioredoxin domain
F7D16_RS10385	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
F7D16_RS10390	COG1981	membrane
F7D16_RS10410	COG0424	maF-like protein
F7D16_RS10420	COG0237	dephospho-CoA kinase activity
F7D16_RS10440	COG4395	Tim44
F7D16_RS10450	COG2840	Smr protein MutS2
F7D16_RS10455	COG1396	sequence-specific DNA binding
F7D16_RS10485	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
F7D16_RS10520	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
F7D16_RS10525	COG0745	RESPONSE REGULATOR receiver
F7D16_RS10530	COG2205	protein histidine kinase activity
F7D16_RS10545	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
F7D16_RS10545	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
F7D16_RS10550	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
F7D16_RS10570	COG2205	protein histidine kinase activity
F7D16_RS10575	COG3178	'Phosphotransferase
F7D16_RS10580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
F7D16_RS10585	COG2887	Belongs to the helicase family. UvrD subfamily
F7D16_RS10590	COG1074	ATP-dependent DNA helicase activity
F7D16_RS10600	COG0285	dihydrofolate synthase activity
F7D16_RS10630	COG1434	Gram-negative-bacterium-type cell wall biogenesis
F7D16_RS10650	COG3135	benzoate transporter
F7D16_RS10660	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
F7D16_RS10715	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
F7D16_RS10730	COG3386	PFAM SMP-30 Gluconolaconase
F7D16_RS10735	COG0189	ligase activity
F7D16_RS10740	COG0606	chelatase, subunit chli
F7D16_RS10750	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
F7D16_RS10760	COG2832	Protein of unknown function (DUF454)
F7D16_RS10765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
F7D16_RS10770	COG0573	inorganic phosphate transmembrane transporter activity
F7D16_RS10780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
F7D16_RS10785	COG0704	Plays a role in the regulation of phosphate uptake
F7D16_RS10790	COG0745	RESPONSE REGULATOR receiver
F7D16_RS10795	COG3773	Cell wall hydrolase
F7D16_RS10805	COG2309	aminopeptidase activity
F7D16_RS10810	COG0783	Belongs to the Dps family
F7D16_RS10820	COG0456	acetyltransferase
F7D16_RS10830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
F7D16_RS10850	COG0815	Transfers the fatty acyl group on membrane lipoproteins
F7D16_RS10855	COG1396	sequence-specific DNA binding
F7D16_RS10860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
F7D16_RS10865	COG0220	tRNA (guanine-N7-)-methyltransferase activity
F7D16_RS10875	COG0195	Participates in both transcription termination and antitermination
F7D16_RS10875	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
F7D16_RS10900	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
F7D16_RS10920	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
F7D16_RS10960	COG0791	NLP P60 protein
F7D16_RS10970	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
F7D16_RS10985	COG1024	Enoyl-CoA hydratase
F7D16_RS11020	COG1519	Transferase
F7D16_RS11040	COG0312	modulator of DNA gyrase
F7D16_RS11045	COG0475	glutathione-regulated potassium exporter activity
F7D16_RS11045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
F7D16_RS11055	COG0612	Peptidase, M16
F7D16_RS11060	COG0612	Peptidase, M16
F7D16_RS11065	COG0742	ribosomal rna small subunit methyltransferase
F7D16_RS11075	COG0590	tRNA wobble adenosine to inosine editing
F7D16_RS11090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
F7D16_RS11095	COG0196	riboflavin kinase activity
F7D16_RS11135	COG2259	Doxx family
F7D16_RS11170	COG2818	Glycosylase
F7D16_RS11175	COG1376	ErfK ybiS ycfS ynhG family protein
F7D16_RS11175	COG1388	LysM domain
F7D16_RS11185	COG0656	L-ascorbic acid biosynthetic process
F7D16_RS11190	COG0247	lactate metabolic process
F7D16_RS11200	COG0277	FAD linked oxidase domain protein
F7D16_RS11205	COG0583	DNA-binding transcription factor activity
F7D16_RS11210	COG2186	Transcriptional regulator
F7D16_RS11245	COG3038	cytochrome b561
F7D16_RS11260	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
F7D16_RS11270	COG0583	DNA-binding transcription factor activity
F7D16_RS11290	COG1338	Plays a role in the flagellum-specific transport system
F7D16_RS11310	COG1706	bacterial-type flagellum-dependent cell motility
F7D16_RS11315	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
F7D16_RS11320	COG4786	Flagellar basal body rod
F7D16_RS11330	COG1558	bacterial-type flagellum-dependent cell motility
F7D16_RS11335	COG1815	bacterial-type flagellum-dependent cell motility
F7D16_RS11340	COG2084	Dehydrogenase
F7D16_RS11345	COG3395	kinase activity
F7D16_RS11350	COG3622	Belongs to the hyi family
F7D16_RS11355	COG1349	DNA-binding transcription factor activity
F7D16_RS11360	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F7D16_RS11365	COG0235	Class ii aldolase
F7D16_RS11370	COG2271	Major facilitator Superfamily
F7D16_RS11375	COG2963	transposase activity
F7D16_RS11400	COG0463	Glycosyl transferase, family 2
F7D16_RS11415	COG0671	phosphoesterase, PA-phosphatase related
F7D16_RS11425	COG1157	protein secretion by the type III secretion system
F7D16_RS11430	COG4786	Flagellar basal body rod
F7D16_RS11440	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
F7D16_RS11455	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
F7D16_RS11465	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F7D16_RS11480	COG1309	transcriptional regulator
F7D16_RS11525	COG0673	inositol 2-dehydrogenase activity
F7D16_RS11560	COG0489	protein tyrosine kinase activity
F7D16_RS11560	COG3206	protein involved in exopolysaccharide biosynthesis
F7D16_RS11570	COG0154	amidase activity
F7D16_RS11575	COG0583	DNA-binding transcription factor activity
F7D16_RS11585	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
F7D16_RS11605	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
F7D16_RS11610	COG4149	molybdate abc transporter
F7D16_RS11615	COG0725	ABC transporter, periplasmic molybdate-binding protein
F7D16_RS11635	COG0800	Aldolase
F7D16_RS11640	COG3108	Peptidase M15
F7D16_RS11650	COG2204	response regulator
F7D16_RS11685	COG0330	HflC and HflK could
F7D16_RS11705	COG1210	Utp--glucose-1-phosphate uridylyltransferase
F7D16_RS11710	COG2951	lytic endotransglycosylase activity
F7D16_RS11715	COG0741	lytic transglycosylase activity
F7D16_RS11740	COG3704	protein secretion by the type IV secretion system
F7D16_RS11760	COG2948	multi-organism process
F7D16_RS11765	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
F7D16_RS11775	COG2885	chlorophyll binding
F7D16_RS11785	COG1113	amino acid transport
F7D16_RS11795	COG0067	glutamate synthase
F7D16_RS11795	COG0070	glutamate synthase
F7D16_RS11795	COG0069	glutamate synthase activity
F7D16_RS11810	COG0071	Belongs to the small heat shock protein (HSP20) family
F7D16_RS11840	COG0483	inositol monophosphate 1-phosphatase activity
F7D16_RS11860	COG4566	intracellular signal transduction
F7D16_RS11865	COG4191	Histidine kinase
F7D16_RS11900	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F7D16_RS11905	COG0508	dehydrogenase complex catalyzes the overall conversion of
F7D16_RS11915	COG1028	Short-chain dehydrogenase reductase Sdr
F7D16_RS11920	COG1028	Short-chain dehydrogenase reductase Sdr
F7D16_RS11955	COG2186	Transcriptional regulator
F7D16_RS11960	COG4944	Protein of unknown function (DUF1109)
F7D16_RS11980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F7D16_RS11985	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F7D16_RS11985	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
F7D16_RS11990	COG1169	isochorismate synthase
F7D16_RS11995	COG1021	2,3-dihydroxybenzoate-AMP ligase
F7D16_RS12000	COG1535	isochorismatase
F7D16_RS12000	COG3433	isochorismatase activity
F7D16_RS12005	COG1028	Short-chain dehydrogenase reductase Sdr
F7D16_RS12025	COG3845	ABC transporter
F7D16_RS12035	COG1079	Belongs to the binding-protein-dependent transport system permease family
F7D16_RS12040	COG1957	nucleoside hydrolase
F7D16_RS12045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F7D16_RS12055	COG1414	Transcriptional regulator
F7D16_RS12065	COG1192	Involved in chromosome partitioning
F7D16_RS12080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
F7D16_RS12095	COG0411	ABC transporter
F7D16_RS12125	COG4206	TonB-dependent receptor
F7D16_RS12140	COG1116	anion transmembrane transporter activity
F7D16_RS12160	COG3842	ATPase activity
F7D16_RS12165	COG1175	transmembrane transport
F7D16_RS12170	COG3833	ABC-type maltose transport systems, permease component
F7D16_RS12175	COG1653	transport
F7D16_RS12180	COG2188	Transcriptional regulator
F7D16_RS12215	COG1228	amidohydrolase
F7D16_RS12220	COG1012	belongs to the aldehyde dehydrogenase family
F7D16_RS12225	COG0531	amino acid
F7D16_RS12235	COG5441	Belongs to the UPF0261 family
F7D16_RS12250	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
F7D16_RS12255	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
F7D16_RS12260	COG1846	Transcriptional regulator
F7D16_RS12280	COG0179	Fumarylacetoacetate (FAA) hydrolase
F7D16_RS12285	COG3971	2-oxopent-4-enoate hydratase activity
F7D16_RS12295	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
F7D16_RS12315	COG4214	carbohydrate transport
F7D16_RS12320	COG1129	ABC transporter
F7D16_RS12325	COG4213	ABC transporter substrate-binding protein
F7D16_RS12340	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
F7D16_RS12360	COG1360	Flagellar Motor Protein
F7D16_RS12410	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
F7D16_RS12425	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F7D16_RS12430	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
F7D16_RS12465	COG0735	belongs to the Fur family
F7D16_RS12470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
F7D16_RS12485	COG0523	cobalamin synthesis protein
F7D16_RS12490	COG1959	2 iron, 2 sulfur cluster binding
F7D16_RS12495	COG2971	BadF BadG BcrA BcrD
F7D16_RS12550	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F7D16_RS12555	COG4608	Belongs to the ABC transporter superfamily
F7D16_RS12560	COG0444	Belongs to the ABC transporter superfamily
F7D16_RS12565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F7D16_RS12565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F7D16_RS12570	COG0601	transmembrane transport
F7D16_RS12590	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
F7D16_RS12595	COG1250	3-hydroxyacyl-CoA dehydrogenase
F7D16_RS12620	COG0747	negative chemotaxis
F7D16_RS12635	COG0444	Belongs to the ABC transporter superfamily
F7D16_RS12655	COG0747	negative chemotaxis
F7D16_RS12660	COG0601	transmembrane transport
F7D16_RS12670	COG0444	Belongs to the ABC transporter superfamily
F7D16_RS12675	COG4608	Belongs to the ABC transporter superfamily
F7D16_RS12680	COG3386	PFAM SMP-30 Gluconolaconase
F7D16_RS12685	COG0154	amidase activity
F7D16_RS12700	COG1176	ABC-type spermidine putrescine transport system, permease component I
F7D16_RS12725	COG0235	Class ii aldolase
F7D16_RS12730	COG3395	kinase activity
F7D16_RS12740	COG2337	Toxic component of a toxin-antitoxin (TA) module
F7D16_RS12750	COG0277	FAD linked oxidase domain protein
F7D16_RS12755	COG0277	FAD linked oxidase domain protein
F7D16_RS12795	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
F7D16_RS12800	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
F7D16_RS12805	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
F7D16_RS12815	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
F7D16_RS12840	COG0778	Nitroreductase
F7D16_RS12850	COG1228	amidohydrolase
F7D16_RS12865	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
F7D16_RS12870	COG1132	(ABC) transporter
F7D16_RS12875	COG0837	glucose binding
F7D16_RS12895	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
F7D16_RS12930	COG2827	Endonuclease containing a URI domain
F7D16_RS12945	COG0242	peptide deformylase activity
F7D16_RS12995	COG0218	Necessary for normal cell division and for the maintenance of normal septation
F7D16_RS13020	COG0251	oxidation-reduction process
F7D16_RS13040	COG2814	Major facilitator Superfamily
F7D16_RS13045	COG1802	Transcriptional regulator
F7D16_RS13050	COG1012	belongs to the aldehyde dehydrogenase family
F7D16_RS13070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F7D16_RS13075	COG0444	Belongs to the ABC transporter superfamily
F7D16_RS13080	COG4608	Belongs to the ABC transporter superfamily
F7D16_RS13090	COG0154	amidase activity
F7D16_RS13095	COG2176	DNA-directed DNA polymerase activity
F7D16_RS13100	COG0579	oxidoreductase
F7D16_RS13105	COG3706	GGDEF domain
F7D16_RS13145	COG1879	ABC-type sugar transport system periplasmic component
F7D16_RS13150	COG1129	ABC transporter
F7D16_RS13155	COG1129	ABC transporter
F7D16_RS13165	COG1172	Belongs to the binding-protein-dependent transport system permease family
F7D16_RS13170	COG0251	oxidation-reduction process
F7D16_RS13180	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
F7D16_RS13185	COG0400	carboxylic ester hydrolase activity
F7D16_RS13195	COG0523	cobalamin synthesis protein
F7D16_RS13215	COG1609	Transcriptional regulator
F7D16_RS13220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
F7D16_RS13235	COG1028	Short-chain dehydrogenase reductase Sdr
F7D16_RS13240	COG5001	Diguanylate cyclase
F7D16_RS13325	COG2011	ABC-type metal ion transport system permease component
F7D16_RS13390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F7D16_RS13400	COG0028	Belongs to the TPP enzyme family
F7D16_RS13405	COG2186	Transcriptional regulator
F7D16_RS13410	COG1172	Belongs to the binding-protein-dependent transport system permease family
F7D16_RS13425	COG0129	dihydroxy-acid dehydratase activity
F7D16_RS13430	COG3734	2-keto-3-deoxy-galactonokinase
F7D16_RS13435	COG0800	Aldolase
F7D16_RS13445	COG1129	ABC transporter
F7D16_RS13450	COG4214	carbohydrate transport
F7D16_RS13485	COG0402	S-adenosylhomocysteine deaminase activity
F7D16_RS13515	COG1522	sequence-specific DNA binding
F7D16_RS13520	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F7D16_RS13530	COG0243	molybdopterin cofactor binding
F7D16_RS13550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F7D16_RS13560	COG2188	Transcriptional regulator
F7D16_RS13565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F7D16_RS13570	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
F7D16_RS13590	COG1012	belongs to the aldehyde dehydrogenase family
F7D16_RS13595	COG5383	Protein conserved in bacteria
F7D16_RS13595	COG5383	Protein conserved in bacteria
F7D16_RS13610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F7D16_RS13620	COG0640	Transcriptional regulator
F7D16_RS13625	COG1902	pentaerythritol trinitrate reductase activity
F7D16_RS13635	COG0010	Belongs to the arginase family
F7D16_RS13640	COG2423	ornithine cyclodeaminase activity
F7D16_RS13690	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
F7D16_RS13690	COG2169	Transcriptional regulator
F7D16_RS13700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
F7D16_RS13705	COG1846	Transcriptional regulator
F7D16_RS13710	COG1764	response to oxidative stress
F7D16_RS13745	COG0339	signal peptide processing
F7D16_RS13755	COG2239	Acts as a magnesium transporter
F7D16_RS13760	COG1217	gtp-binding protein TYPA
F7D16_RS13790	COG1349	DNA-binding transcription factor activity
F7D16_RS13825	COG1129	ABC transporter
F7D16_RS13830	COG1172	Belongs to the binding-protein-dependent transport system permease family
F7D16_RS13845	COG1349	DNA-binding transcription factor activity
F7D16_RS13850	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
F7D16_RS13850	COG0546	phosphoglycolate phosphatase activity
F7D16_RS13855	COG0277	FAD linked oxidase domain protein
F7D16_RS13865	COG1088	dTDP-glucose 4,6-dehydratase activity
F7D16_RS13900	COG3586	endonuclease activity
F7D16_RS13910	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
F7D16_RS13985	COG1201	RNA secondary structure unwinding
F7D16_RS14000	COG0730	response to heat
F7D16_RS14010	COG0789	Transcriptional regulator
F7D16_RS14015	COG1993	acr, cog1993
F7D16_RS14020	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
F7D16_RS14035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
F7D16_RS14050	COG1802	Transcriptional regulator
F7D16_RS14055	COG1904	glucuronate isomerase
F7D16_RS14065	COG0246	Mannitol dehydrogenase
F7D16_RS14075	COG3842	ATPase activity
F7D16_RS14085	COG4208	sulfate ABC transporter
F7D16_RS14100	COG0747	negative chemotaxis
F7D16_RS14105	COG0601	transmembrane transport
F7D16_RS14110	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F7D16_RS14150	COG1960	acyl-CoA dehydrogenase activity
F7D16_RS14155	COG0183	Belongs to the thiolase family
F7D16_RS14160	COG1024	Enoyl-CoA hydratase
F7D16_RS14160	COG1250	3-hydroxyacyl-CoA dehydrogenase
F7D16_RS14185	COG0288	reversible hydration of carbon dioxide
F7D16_RS14195	COG0747	negative chemotaxis
F7D16_RS14205	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F7D16_RS14215	COG4172	Belongs to the ABC transporter superfamily
F7D16_RS14230	COG0129	dihydroxy-acid dehydratase activity
F7D16_RS14235	COG0363	glucosamine-6-phosphate deaminase activity
F7D16_RS14240	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
F7D16_RS14285	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F7D16_RS14295	COG0174	glutamine synthetase
F7D16_RS14330	COG1846	Transcriptional regulator
F7D16_RS14360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F7D16_RS14365	COG1120	ATPase activity
F7D16_RS14380	COG0251	oxidation-reduction process
F7D16_RS14385	COG0395	ABC-type sugar transport system, permease component
F7D16_RS14410	COG1737	Transcriptional regulator
F7D16_RS14435	COG4176	ABC-type proline glycine betaine transport system permease component
F7D16_RS14490	COG0404	The glycine cleavage system catalyzes the degradation of glycine
F7D16_RS14495	COG0509	glycine decarboxylation via glycine cleavage system
F7D16_RS14515	COG1522	sequence-specific DNA binding
F7D16_RS14525	COG1840	ABC-type Fe3 transport system, periplasmic component
F7D16_RS14535	COG3842	ATPase activity
F7D16_RS14545	COG3718	enzyme involved in inositol metabolism
F7D16_RS14555	COG3962	Belongs to the TPP enzyme family
F7D16_RS14560	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
F7D16_RS14570	COG0673	inositol 2-dehydrogenase activity
F7D16_RS14585	COG0450	alkyl hydroperoxide reductase
F7D16_RS14595	COG0477	Major facilitator Superfamily
F7D16_RS14610	COG2132	Multicopper oxidase
F7D16_RS14635	COG1840	ABC-type Fe3 transport system, periplasmic component
F7D16_RS14665	COG1653	transport
F7D16_RS14670	COG1175	transmembrane transport
F7D16_RS14675	COG0395	ABC-type sugar transport system, permease component
F7D16_RS14680	COG3842	ATPase activity
F7D16_RS14690	COG0477	Major facilitator Superfamily
F7D16_RS14705	COG0248	Ppx GppA phosphatase
F7D16_RS14710	COG1126	abc transporter atp-binding protein
F7D16_RS14715	COG0765	amino acid transport
F7D16_RS14720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
F7D16_RS14735	COG4604	ABC transporter, ATP-binding protein
F7D16_RS14740	COG4605	iron ion homeostasis
F7D16_RS14745	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
F7D16_RS14750	COG4607	ABC-type enterochelin transport system periplasmic component
F7D16_RS14785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
F7D16_RS14805	COG2252	PERMEase
F7D16_RS14815	COG3273	potassium ion transport
F7D16_RS14815	COG0471	metal ion transport
F7D16_RS14825	COG0395	ABC-type sugar transport system, permease component
F7D16_RS14830	COG1175	transmembrane transport
F7D16_RS14845	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
F7D16_RS14850	COG3842	ATPase activity
F7D16_RS14870	COG0683	leucine binding
F7D16_RS14875	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
F7D16_RS14880	COG3485	protocatechuate 3,4-dioxygenase
F7D16_RS14890	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
F7D16_RS14895	COG2267	carboxylic ester hydrolase activity
F7D16_RS14900	COG0583	DNA-binding transcription factor activity
F7D16_RS14915	COG1414	Transcriptional regulator
F7D16_RS14925	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
F7D16_RS14955	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
F7D16_RS14975	COG2176	DNA-directed DNA polymerase activity
F7D16_RS15015	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
F7D16_RS15060	COG0557	exoribonuclease II activity
F7D16_RS15065	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
F7D16_RS15065	COG1754	DNA topoisomerase type I activity
F7D16_RS15070	COG0758	DNA mediated transformation
F7D16_RS15080	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
F7D16_RS15090	COG1960	acyl-CoA dehydrogenase activity
F7D16_RS15120	COG0187	DNA topoisomerase II activity
F7D16_RS15125	COG0697	spore germination
F7D16_RS15165	COG0785	Cytochrome C biogenesis protein
F7D16_RS15175	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
F7D16_RS15185	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
F7D16_RS15190	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
F7D16_RS15195	COG0346	lactoylglutathione lyase activity
F7D16_RS15220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
F7D16_RS15225	COG1183	phosphatidylcholine synthase activity
F7D16_RS15235	COG3845	ABC transporter
F7D16_RS15240	COG4603	Belongs to the binding-protein-dependent transport system permease family
F7D16_RS15275	COG1959	2 iron, 2 sulfur cluster binding
F7D16_RS15280	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
F7D16_RS15305	COG2963	transposase activity
F7D16_RS15310	COG3436	PFAM IS66 Orf2 family protein
F7D16_RS15315	COG2433	Pfam Transposase IS66
F7D16_RS15365	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
F7D16_RS15380	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
F7D16_RS15405	COG0601	transmembrane transport
F7D16_RS15410	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
F7D16_RS15415	COG4172	Belongs to the ABC transporter superfamily
F7D16_RS15420	COG3145	DNA-N1-methyladenine dioxygenase activity
F7D16_RS15430	COG0477	Major facilitator Superfamily
F7D16_RS15470	COG0022	dehydrogenase e1 component
F7D16_RS15490	COG0673	inositol 2-dehydrogenase activity
F7D16_RS15495	COG0395	ABC-type sugar transport system, permease component
F7D16_RS15500	COG1175	transmembrane transport
F7D16_RS15515	COG2971	BadF BadG BcrA BcrD
F7D16_RS15520	COG2188	Transcriptional regulator
F7D16_RS15530	COG1294	oxidase, subunit
F7D16_RS15535	COG1271	oxidase subunit
F7D16_RS15540	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
F7D16_RS15545	COG4988	ABC transporter
F7D16_RS15565	COG2212	antiporter activity
F7D16_RS15570	COG1863	multisubunit Na H antiporter MnhE subunit
F7D16_RS15575	COG0651	ATP synthesis coupled electron transport
F7D16_RS15580	COG1006	Multisubunit Na H antiporter MnhC subunit
F7D16_RS15585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
F7D16_RS15585	COG2111	Na H antiporter
F7D16_RS15600	COG0521	Mo-molybdopterin cofactor biosynthetic process
F7D16_RS15615	COG0156	8-amino-7-oxononanoate synthase activity
F7D16_RS15625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
F7D16_RS15630	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
F7D16_RS15650	COG1115	amino acid carrier protein
F7D16_RS15665	COG1252	NADH dehydrogenase
F7D16_RS15695	COG2205	protein histidine kinase activity
F7D16_RS15730	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F7D16_RS15740	COG0842	Transport permease protein
F7D16_RS15745	COG1131	(ABC) transporter
F7D16_RS15780	COG0640	Transcriptional regulator
F7D16_RS15785	COG2354	Protein conserved in bacteria
F7D16_RS15790	COG0242	peptide deformylase activity
F7D16_RS15795	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
F7D16_RS15810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
F7D16_RS15815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
F7D16_RS15825	COG0183	Belongs to the thiolase family
F7D16_RS15835	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
F7D16_RS15840	COG0583	DNA-binding transcription factor activity
F7D16_RS15860	COG2233	PERMEase
F7D16_RS15865	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
F7D16_RS15885	COG4310	Domain of unknown function (DUF2172)
F7D16_RS15890	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
F7D16_RS15930	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
F7D16_RS15950	COG0110	maltose O-acetyltransferase activity
F7D16_RS15955	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
F7D16_RS15980	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
F7D16_RS16000	COG2197	response regulator
F7D16_RS16015	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
F7D16_RS16020	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
F7D16_RS16020	COG1940	carbohydrate kinase activity
F7D16_RS16025	COG2186	Transcriptional regulator
F7D16_RS16030	COG0747	negative chemotaxis
F7D16_RS16045	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F7D16_RS16075	COG0683	leucine binding
F7D16_RS16090	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
F7D16_RS16095	COG1028	Short-chain dehydrogenase reductase Sdr
F7D16_RS16115	COG1028	Short-chain dehydrogenase reductase Sdr
F7D16_RS16115	COG3321	synthase
F7D16_RS16115	COG0604	alcohol dehydrogenase
F7D16_RS16120	COG1802	Transcriptional regulator
F7D16_RS16125	COG2124	cytochrome p450
F7D16_RS16130	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
F7D16_RS16135	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
F7D16_RS16195	COG0753	catalase activity
F7D16_RS16200	COG0583	DNA-binding transcription factor activity
F7D16_RS16205	COG3258	Cytochrome c
F7D16_RS16220	COG3191	aminopeptidase activity
F7D16_RS16225	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
F7D16_RS16245	COG4943	cyclic-guanylate-specific phosphodiesterase activity
F7D16_RS16265	COG0531	amino acid
F7D16_RS16315	COG1177	transmembrane transport
F7D16_RS16320	COG1176	ABC-type spermidine putrescine transport system, permease component I
F7D16_RS16325	COG3842	ATPase activity
F7D16_RS16350	COG2894	cell division
F7D16_RS16380	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
F7D16_RS16400	COG0673	inositol 2-dehydrogenase activity
F7D16_RS16425	COG1653	transport
F7D16_RS16430	COG1609	Transcriptional regulator
F7D16_RS16440	COG2223	nitrite transmembrane transporter activity
F7D16_RS16445	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
F7D16_RS16450	COG1140	nitrate reductase beta subunit
F7D16_RS16455	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
F7D16_RS16460	COG2181	nitrate reductase activity
F7D16_RS16465	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
F7D16_RS16480	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
F7D16_RS16490	COG0826	peptidase U32
F7D16_RS16510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
F7D16_RS16535	COG1477	protein flavinylation
F7D16_RS16580	COG4178	(ABC) transporter
F7D16_RS16590	COG5654	RES domain protein
F7D16_RS16600	COG1069	ribulokinase activity
F7D16_RS16615	COG4214	carbohydrate transport
F7D16_RS16675	COG2151	metal-sulfur cluster biosynthetic enzyme
F7D16_RS16695	COG4548	von Willebrand factor, type A
F7D16_RS16700	COG0714	Associated with various cellular activities
F7D16_RS16705	COG3256	nitric oxide reductase
F7D16_RS16720	COG1845	cytochrome c oxidase, subunit III
F7D16_RS16735	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
F7D16_RS16740	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
F7D16_RS16765	COG1477	protein flavinylation
F7D16_RS16810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
F7D16_RS16820	COG1024	Enoyl-CoA hydratase
F7D16_RS16830	COG1960	acyl-CoA dehydrogenase activity