locus-tag	class	description
TI82_RS00025	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TI82_RS00030	COG4172	Belongs to the ABC transporter superfamily
TI82_RS00035	COG4239	(ABC) transporter, permease
TI82_RS00040	COG4174	ABC transporter (Permease)
TI82_RS00050	COG4166	transmembrane transport
TI82_RS00070	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
TI82_RS00085	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
TI82_RS00090	COG1960	acyl-CoA dehydrogenase activity
TI82_RS00095	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
TI82_RS00130	COG0539	negative regulation of cytoplasmic translation
TI82_RS00140	COG0583	DNA-binding transcription factor activity
TI82_RS00150	COG2951	lytic endotransglycosylase activity
TI82_RS00165	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
TI82_RS00175	COG2816	NAD+ diphosphatase activity
TI82_RS00180	COG0077	Prephenate dehydratase
TI82_RS00180	COG1605	Chorismate mutase
TI82_RS00190	COG3474	cytochrome
TI82_RS00200	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TI82_RS00205	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TI82_RS00210	COG1845	cytochrome c oxidase, subunit III
TI82_RS00215	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
TI82_RS00235	COG1376	ErfK ybiS ycfS ynhG family protein
TI82_RS00260	COG0346	lactoylglutathione lyase activity
TI82_RS00265	COG0489	protein tyrosine kinase activity
TI82_RS00270	COG0033	Phosphoglucomutase
TI82_RS00280	COG1073	alpha beta
TI82_RS00285	COG1072	(Pantothenic acid kinase))
TI82_RS00315	COG1272	protein, Hemolysin III
TI82_RS00375	COG3339	Conserved Protein
TI82_RS00390	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
TI82_RS00400	COG4181	ATPase activity
TI82_RS00410	COG0670	Belongs to the BI1 family
TI82_RS00430	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
TI82_RS00440	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TI82_RS00445	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
TI82_RS00455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TI82_RS00495	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
TI82_RS00505	COG4208	sulfate ABC transporter
TI82_RS00510	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
TI82_RS00515	COG3459	Glycosyltransferase 36 associated
TI82_RS00525	COG0384	phenazine biosynthesis protein PhzF
TI82_RS00530	COG2226	methyltransferase
TI82_RS00540	COG1028	Short-chain dehydrogenase reductase Sdr
TI82_RS00545	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TI82_RS00560	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TI82_RS00565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
TI82_RS00570	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TI82_RS00570	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TI82_RS00585	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
TI82_RS00595	COG2153	protein acetylation
TI82_RS00610	COG1643	Atp-dependent helicase
TI82_RS00615	COG1643	Atp-dependent helicase
TI82_RS00625	COG3293	Transposase
TI82_RS00635	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
TI82_RS00645	COG1376	ErfK ybiS ycfS ynhG family protein
TI82_RS00645	COG1388	LysM domain
TI82_RS00650	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
TI82_RS00660	COG0180	Tryptophanyl-tRNA synthetase
TI82_RS00665	COG0728	peptidoglycan biosynthetic process
TI82_RS00675	COG0281	malic enzyme
TI82_RS00675	COG0280	phosphate acetyltransferase
TI82_RS00695	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TI82_RS00700	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
TI82_RS00700	COG0116	Belongs to the methyltransferase superfamily
TI82_RS00715	COG0616	signal peptide processing
TI82_RS00725	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
TI82_RS00730	COG1137	ATPase activity
TI82_RS00735	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
TI82_RS00740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
TI82_RS00745	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
TI82_RS00755	COG0071	Belongs to the small heat shock protein (HSP20) family
TI82_RS00775	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TI82_RS00780	COG2860	membrane
TI82_RS00805	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
TI82_RS00810	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TI82_RS00815	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
TI82_RS00825	COG1648	precorrin-2 dehydrogenase activity
TI82_RS00825	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TI82_RS00835	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
TI82_RS00840	COG0175	sulfate reduction
TI82_RS00855	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TI82_RS00875	COG2197	response regulator
TI82_RS00880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
TI82_RS00895	COG1218	3'(2'),5'-bisphosphate nucleotidase
TI82_RS00910	COG2197	response regulator
TI82_RS00930	COG1012	belongs to the aldehyde dehydrogenase family
TI82_RS00960	COG1012	belongs to the aldehyde dehydrogenase family
TI82_RS00965	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
TI82_RS00970	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
TI82_RS00975	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
TI82_RS01000	COG0351	phosphomethylpyrimidine kinase
TI82_RS01005	COG5001	Diguanylate cyclase
TI82_RS01020	COG1174	glycine betaine transport
TI82_RS01025	COG1125	glycine betaine transport
TI82_RS01030	COG1174	glycine betaine transport
TI82_RS01035	COG1732	Glycine betaine
TI82_RS01045	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
TI82_RS01060	COG0404	The glycine cleavage system catalyzes the degradation of glycine
TI82_RS01060	COG0446	pyridine nucleotide-disulphide oxidoreductase
TI82_RS01075	COG1414	Transcriptional regulator
TI82_RS01085	COG1175	transmembrane transport
TI82_RS01090	COG0395	ABC-type sugar transport system, permease component
TI82_RS01095	COG3842	ATPase activity
TI82_RS01100	COG4948	Mandelate Racemase Muconate Lactonizing
TI82_RS01105	COG3254	rhamnose metabolic process
TI82_RS01120	COG1028	Short-chain dehydrogenase reductase Sdr
TI82_RS01130	COG4948	Mandelate Racemase Muconate Lactonizing
TI82_RS01155	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
TI82_RS01170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
TI82_RS01210	COG3617	BRO family, N-terminal domain
TI82_RS01215	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TI82_RS01285	COG4191	Histidine kinase
TI82_RS01290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TI82_RS01295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TI82_RS01310	COG1309	transcriptional regulator
TI82_RS01315	COG0494	nUDIX hydrolase
TI82_RS01325	COG0493	'glutamate synthase
TI82_RS01355	COG0318	PFAM AMP-dependent synthetase and ligase
TI82_RS01390	COG2326	polyphosphate kinase activity
TI82_RS01395	COG5002	protein histidine kinase activity
TI82_RS01405	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TI82_RS01415	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
TI82_RS01435	COG0717	Belongs to the dCTP deaminase family
TI82_RS01455	COG0534	Mate efflux family protein
TI82_RS01485	COG2205	protein histidine kinase activity
TI82_RS01485	COG0784	Response regulator, receiver
TI82_RS01495	COG0156	8-amino-7-oxononanoate synthase activity
TI82_RS01520	COG0583	DNA-binding transcription factor activity
TI82_RS01525	COG1380	Effector of murein hydrolase LrgA
TI82_RS01530	COG1346	cytolysis
TI82_RS01555	COG0019	diaminopimelate decarboxylase activity
TI82_RS01595	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
TI82_RS01600	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
TI82_RS01605	COG3257	ureidoglycine aminohydrolase activity
TI82_RS01610	COG3195	allantoin biosynthetic process
TI82_RS01610	COG3648	Uricase
TI82_RS01620	COG2080	2 iron, 2 sulfur cluster binding
TI82_RS01625	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TI82_RS01635	COG0583	DNA-binding transcription factor activity
TI82_RS01645	COG0402	S-adenosylhomocysteine deaminase activity
TI82_RS01700	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
TI82_RS01700	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
TI82_RS01710	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
TI82_RS01710	COG2169	Transcriptional regulator
TI82_RS01715	COG1393	Belongs to the ArsC family
TI82_RS01725	COG0477	Major facilitator Superfamily
TI82_RS01735	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
TI82_RS01760	COG3773	Cell wall hydrolase
TI82_RS01845	COG0142	geranyltranstransferase activity
TI82_RS01860	COG0751	glycine-tRNA ligase activity
TI82_RS01865	COG0751	glycine-tRNA ligase activity
TI82_RS01870	COG0009	L-threonylcarbamoyladenylate synthase
TI82_RS01900	COG1960	acyl-CoA dehydrogenase activity
TI82_RS01915	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
TI82_RS01930	COG0484	heat shock protein binding
TI82_RS01935	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TI82_RS01945	COG1278	Cold shock
TI82_RS01975	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TI82_RS01975	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
TI82_RS01980	COG0123	including yeast histone deacetylase and acetoin utilization protein
TI82_RS01985	COG1722	exodeoxyribonuclease VII activity
TI82_RS02005	COG1741	Belongs to the pirin family
TI82_RS02015	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
TI82_RS02040	COG5265	(ABC) transporter
TI82_RS02050	COG1183	phosphatidylcholine synthase activity
TI82_RS02055	COG1028	Short-chain dehydrogenase reductase Sdr
TI82_RS02060	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
TI82_RS02075	COG0305	Participates in initiation and elongation during chromosome replication
TI82_RS02080	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
TI82_RS02105	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
TI82_RS02120	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TI82_RS02125	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
TI82_RS02130	COG1561	YicC-like family, N-terminal region
TI82_RS02135	COG0194	GDP metabolic process
TI82_RS02140	COG0312	modulator of DNA gyrase
TI82_RS02150	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
TI82_RS02155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
TI82_RS02205	COG0678	peroxiredoxin activity
TI82_RS02205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
TI82_RS02225	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
TI82_RS02230	COG0612	Peptidase, M16
TI82_RS02245	COG4943	cyclic-guanylate-specific phosphodiesterase activity
TI82_RS02255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TI82_RS02275	COG1194	a g-specific adenine glycosylase
TI82_RS02290	COG1196	nuclear chromosome segregation
TI82_RS02305	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
TI82_RS02305	COG0574	Belongs to the PEP-utilizing enzyme family
TI82_RS02330	COG1268	BioY protein
TI82_RS02355	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
TI82_RS02385	COG2801	Transposase and inactivated derivatives
TI82_RS02415	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
TI82_RS02420	COG3293	Transposase
TI82_RS02430	COG3293	Transposase
TI82_RS02450	COG3293	Transposase
TI82_RS02460	COG2801	Transposase and inactivated derivatives
TI82_RS02475	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
TI82_RS02475	COG0662	Cupin 2, conserved barrel domain protein
TI82_RS02480	COG2942	2-epimerase
TI82_RS02485	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
TI82_RS02485	COG0438	transferase activity, transferring glycosyl groups
TI82_RS02490	COG1129	ABC transporter
TI82_RS02495	COG1172	Belongs to the binding-protein-dependent transport system permease family
TI82_RS02500	COG1879	ABC-type sugar transport system periplasmic component
TI82_RS02510	COG0673	inositol 2-dehydrogenase activity
TI82_RS02520	COG1070	Carbohydrate kinase
TI82_RS02555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
TI82_RS02565	COG2336	PFAM SpoVT AbrB
TI82_RS02575	COG2186	Transcriptional regulator
TI82_RS02580	COG2807	transmembrane transport
TI82_RS02590	COG0433	COG0433 Predicted ATPase
TI82_RS02595	COG1376	ErfK ybiS ycfS ynhG family protein
TI82_RS02610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
TI82_RS02625	COG4957	zinc ion binding
TI82_RS02635	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
TI82_RS02650	COG2166	iron-sulfur cluster assembly
TI82_RS02660	COG2205	protein histidine kinase activity
TI82_RS02690	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TI82_RS02705	COG4695	Portal protein
TI82_RS02805	COG4235	cytochrome complex assembly
TI82_RS02815	COG1138	Cytochrome C-type biogenesis protein
TI82_RS02820	COG3088	subunit of a heme lyase
TI82_RS02850	COG2205	protein histidine kinase activity
TI82_RS02850	COG2202	Pas domain
TI82_RS02855	COG0308	aminopeptidase N
TI82_RS02870	COG1573	uracil-dna glycosylase
TI82_RS02885	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
TI82_RS02900	COG0625	glutathione transferase activity
TI82_RS02935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
TI82_RS02940	COG4974	Belongs to the 'phage' integrase family
TI82_RS02970	COG3743	rRNA binding
TI82_RS02970	COG0261	This protein binds to 23S rRNA in the presence of protein L20
TI82_RS02975	COG0741	lytic transglycosylase activity
TI82_RS03015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
TI82_RS03020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
TI82_RS03025	COG2223	nitrite transmembrane transporter activity
TI82_RS03030	COG2207	Transcriptional regulator
TI82_RS03045	COG0681	Belongs to the peptidase S26 family
TI82_RS03070	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
TI82_RS03080	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
TI82_RS03100	COG0494	nUDIX hydrolase
TI82_RS03125	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
TI82_RS03135	COG0739	heme binding
TI82_RS03145	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
TI82_RS03150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TI82_RS03155	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
TI82_RS03185	COG0488	(ABC) transporter
TI82_RS03205	COG0314	molybdopterin synthase activity
TI82_RS03210	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
TI82_RS03215	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
TI82_RS03250	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
TI82_RS03260	COG0243	molybdopterin cofactor binding
TI82_RS03270	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
TI82_RS03280	COG0628	permease
TI82_RS03300	COG1028	Short-chain dehydrogenase reductase Sdr
TI82_RS03310	COG1620	l-lactate permease
TI82_RS03415	COG0626	cystathionine gamma-synthase activity
TI82_RS03430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TI82_RS03435	COG4597	amino acid ABC transporter
TI82_RS03440	COG0765	amino acid transport
TI82_RS03445	COG1126	abc transporter atp-binding protein
TI82_RS03460	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
TI82_RS03470	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
TI82_RS03485	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TI82_RS03500	COG0113	porphobilinogen synthase activity
TI82_RS03520	COG2989	Protein conserved in bacteria
TI82_RS03535	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TI82_RS03535	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
TI82_RS03560	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TI82_RS03640	COG0010	Belongs to the arginase family
TI82_RS03705	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
TI82_RS03725	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
TI82_RS03730	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
TI82_RS03770	COG1007	ATP synthesis coupled electron transport
TI82_RS03785	COG0346	lactoylglutathione lyase activity
TI82_RS03840	COG0483	inositol monophosphate 1-phosphatase activity
TI82_RS03845	COG2814	Major facilitator Superfamily
TI82_RS03880	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
TI82_RS03905	COG2514	catechol 2,3-dioxygenase activity
TI82_RS03910	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
TI82_RS03930	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TI82_RS03935	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
TI82_RS03940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
TI82_RS03955	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
TI82_RS03960	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
TI82_RS03965	COG3454	Phosphonate metabolism
TI82_RS03970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
TI82_RS03980	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
TI82_RS04005	COG1522	sequence-specific DNA binding
TI82_RS04010	COG1573	uracil-dna glycosylase
TI82_RS04035	COG0316	Belongs to the HesB IscA family
TI82_RS04055	COG1472	Belongs to the glycosyl hydrolase 3 family
TI82_RS04060	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
TI82_RS04065	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
TI82_RS04075	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
TI82_RS04080	COG0805	protein transport
TI82_RS04095	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TI82_RS04115	COG1862	Preprotein translocase
TI82_RS04180	COG4765	Protein conserved in bacteria
TI82_RS04190	COG0439	Biotin carboxylase
TI82_RS04195	COG0511	ligase activity, forming carbon-carbon bonds
TI82_RS04210	COG0501	Belongs to the peptidase M48B family
TI82_RS04215	COG0436	Aminotransferase
TI82_RS04220	COG1530	ribonuclease E activity
TI82_RS04230	COG0860	N-Acetylmuramoyl-L-alanine amidase
TI82_RS04235	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
TI82_RS04245	COG3293	Transposase
TI82_RS04255	COG2833	Protein of unknown function (DUF455)
TI82_RS04260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
TI82_RS04285	COG2945	thiolester hydrolase activity
TI82_RS04295	COG0719	Fe-S assembly protein
TI82_RS04300	COG0396	ATPase activity
TI82_RS04305	COG0719	Fe-S assembly protein
TI82_RS04310	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
TI82_RS04315	COG2151	metal-sulfur cluster biosynthetic enzyme
TI82_RS04335	COG0513	Belongs to the DEAD box helicase family
TI82_RS04340	COG0316	Belongs to the HesB IscA family
TI82_RS04355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
TI82_RS04385	COG2084	Dehydrogenase
TI82_RS04390	COG0625	glutathione transferase activity
TI82_RS04445	COG2989	Protein conserved in bacteria
TI82_RS04540	COG3293	Transposase
TI82_RS04575	COG1393	Belongs to the ArsC family
TI82_RS04605	COG0084	hydrolase, TatD family'
TI82_RS04640	COG0174	glutamine synthetase
TI82_RS04645	COG0347	Belongs to the P(II) protein family
TI82_RS04650	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
TI82_RS04650	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
TI82_RS04660	COG0546	phosphoglycolate phosphatase activity
TI82_RS04680	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
TI82_RS04685	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
TI82_RS04705	COG0281	malic enzyme
TI82_RS04705	COG0280	phosphate acetyltransferase
TI82_RS04710	COG4948	Mandelate Racemase Muconate Lactonizing
TI82_RS04715	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
TI82_RS04720	COG1127	ABC transporter
TI82_RS04740	COG0633	Ferredoxin
TI82_RS04755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
TI82_RS04765	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
TI82_RS04780	COG3106	COG3106 Predicted ATPase
TI82_RS04805	COG1635	Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur
TI82_RS04820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TI82_RS04840	COG1546	Belongs to the CinA family
TI82_RS04840	COG1058	Belongs to the CinA family
TI82_RS04855	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
TI82_RS04860	COG0513	Belongs to the DEAD box helicase family
TI82_RS04865	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
TI82_RS04870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
TI82_RS04875	COG2897	thiosulfate sulfurtransferase activity
TI82_RS04890	COG0427	acetyl-CoA hydrolase
TI82_RS04895	COG2814	Major facilitator Superfamily
TI82_RS04900	COG1566	PFAM secretion protein HlyD family protein
TI82_RS04910	COG0006	proline dipeptidase activity
TI82_RS04915	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
TI82_RS04925	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
TI82_RS04930	COG3956	TIGRFAM MazG family protein
TI82_RS04935	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TI82_RS04955	COG1686	Belongs to the peptidase S11 family
TI82_RS04980	COG1752	Esterase of the alpha-beta hydrolase superfamily
TI82_RS05015	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
TI82_RS05020	COG3617	BRO family, N-terminal domain
TI82_RS05030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
TI82_RS05035	COG1960	acyl-CoA dehydrogenase activity
TI82_RS05040	COG0583	DNA-binding transcription factor activity
TI82_RS05045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TI82_RS05050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TI82_RS05055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TI82_RS05095	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
TI82_RS05100	COG2095	MarC family integral membrane protein
TI82_RS05110	COG2188	Transcriptional regulator
TI82_RS05145	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
TI82_RS05160	COG0569	domain protein
TI82_RS05165	COG2204	response regulator
TI82_RS05170	COG5000	phosphorelay sensor kinase activity
TI82_RS05175	COG2204	response regulator
TI82_RS05180	COG3852	Histidine kinase
TI82_RS05195	COG1546	Belongs to the CinA family
TI82_RS05195	COG1058	Belongs to the CinA family
TI82_RS05200	COG1028	Short-chain dehydrogenase reductase Sdr
TI82_RS05205	COG2867	negative regulation of translational initiation
TI82_RS05220	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
TI82_RS05225	COG0508	dehydrogenase complex catalyzes the overall conversion of
TI82_RS05230	COG0022	dehydrogenase e1 component
TI82_RS05230	COG0508	dehydrogenase complex catalyzes the overall conversion of
TI82_RS05235	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
TI82_RS05240	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
TI82_RS05280	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TI82_RS05300	COG0303	'Molybdopterin
TI82_RS05310	COG2333	competence protein COMEC
TI82_RS05310	COG0658	competence protein
TI82_RS05320	COG0372	Belongs to the citrate synthase family
TI82_RS05325	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
TI82_RS05350	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TI82_RS05405	COG0584	glycerophosphoryl diester phosphodiesterase
TI82_RS05415	COG0537	adenosine 5'-monophosphoramidase activity
TI82_RS05430	COG1686	Belongs to the peptidase S11 family
TI82_RS05445	COG1760	l-serine dehydratase
TI82_RS05495	COG3800	Transcriptional regulator
TI82_RS05495	COG1396	sequence-specific DNA binding
TI82_RS05505	COG4770	biotin carboxylase activity
TI82_RS05510	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TI82_RS05510	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
TI82_RS05525	COG2358	TRAP transporter, solute receptor (TAXI family
TI82_RS05535	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
TI82_RS05540	COG0693	protein deglycase activity
TI82_RS05550	COG0538	isocitrate dehydrogenase activity
TI82_RS05555	COG1785	Belongs to the alkaline phosphatase family
TI82_RS05570	COG2885	chlorophyll binding
TI82_RS05580	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
TI82_RS05585	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
TI82_RS05630	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
TI82_RS05695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
TI82_RS05785	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
TI82_RS05810	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
TI82_RS05865	COG0346	lactoylglutathione lyase activity
TI82_RS05885	COG1494	fructose-1,6-bisphosphatase
TI82_RS05895	COG0436	Aminotransferase
TI82_RS05930	COG0024	Methionine aminopeptidase
TI82_RS05980	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
TI82_RS06135	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
TI82_RS06135	COG4651	solute:proton antiporter activity
TI82_RS06150	COG4208	sulfate ABC transporter
TI82_RS06155	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
TI82_RS06160	COG4150	thiosulfate binding
TI82_RS06170	COG1253	flavin adenine dinucleotide binding
TI82_RS06175	COG0586	Pfam SNARE associated Golgi protein
TI82_RS06190	COG4154	Belongs to the RbsD FucU family
TI82_RS06195	COG1028	Short-chain dehydrogenase reductase Sdr
TI82_RS06205	COG1172	Belongs to the binding-protein-dependent transport system permease family
TI82_RS06220	COG1120	ATPase activity
TI82_RS06225	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
TI82_RS06240	COG0842	Transport permease protein
TI82_RS06245	COG0842	Transport permease protein
TI82_RS06245	COG1129	ABC transporter
TI82_RS06250	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TI82_RS06255	COG1649	PFAM Uncharacterised BCR, COG1649
TI82_RS06295	COG4413	Urea transporter
TI82_RS06305	COG0310	cobalt ion transport
TI82_RS06345	COG0384	phenazine biosynthesis protein PhzF
TI82_RS06365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
TI82_RS06400	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
TI82_RS06405	COG0440	acetolactate synthase activity
TI82_RS06410	COG0028	Belongs to the TPP enzyme family
TI82_RS06420	COG0560	Phosphoserine phosphatase
TI82_RS06425	COG2081	HI0933 family
TI82_RS06440	COG0330	HflC and HflK could
TI82_RS06465	COG2814	Major facilitator Superfamily
TI82_RS06505	COG0277	FAD linked oxidase domain protein
TI82_RS06520	COG0210	DNA helicase
TI82_RS06535	COG1999	signal sequence binding
TI82_RS06545	COG0006	proline dipeptidase activity
TI82_RS06565	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
TI82_RS06575	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
TI82_RS06580	COG0849	cell division
TI82_RS06585	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
TI82_RS06650	COG1914	H( )-stimulated, divalent metal cation uptake system
TI82_RS06660	COG3023	N-Acetylmuramoyl-L-alanine amidase
TI82_RS06665	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
TI82_RS06695	COG0640	Transcriptional regulator
TI82_RS06705	COG0477	Major facilitator Superfamily
TI82_RS06725	COG2267	carboxylic ester hydrolase activity
TI82_RS06750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
TI82_RS06755	COG2824	Alkylphosphonate utilization operon protein PhnA
TI82_RS06760	COG1335	isochorismatase
TI82_RS06775	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
TI82_RS06815	COG2968	Membrane
TI82_RS06835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TI82_RS06840	COG0358	DNA primase activity
TI82_RS06860	COG2321	neutral zinc metallopeptidase
TI82_RS06880	COG1136	(ABC) transporter
TI82_RS06890	COG1278	Cold shock
TI82_RS06895	COG0625	glutathione transferase activity
TI82_RS06900	COG0436	Aminotransferase
TI82_RS06910	COG0583	DNA-binding transcription factor activity
TI82_RS06915	COG0492	ferredoxin-NADP+ reductase activity
TI82_RS06920	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
TI82_RS06925	COG1522	sequence-specific DNA binding
TI82_RS06970	COG0556	nucleotide-excision repair
TI82_RS06975	COG0741	lytic transglycosylase activity
TI82_RS06975	COG0739	heme binding
TI82_RS06975	COG1196	nuclear chromosome segregation
TI82_RS06980	COG1278	Cold shock
TI82_RS06990	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
TI82_RS07005	COG1846	Transcriptional regulator
TI82_RS07010	COG0745	RESPONSE REGULATOR receiver
TI82_RS07015	COG2205	protein histidine kinase activity
TI82_RS07025	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
TI82_RS07050	COG1496	oxidoreductase activity
TI82_RS07090	COG0012	GTP binding
TI82_RS07095	COG2030	dehydratase
TI82_RS07110	COG2857	Cytochrome c1
TI82_RS07110	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
TI82_RS07125	COG1132	(ABC) transporter
TI82_RS07135	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
TI82_RS07155	COG3153	acetyltransferase
TI82_RS07170	COG0617	tRNA 3'-terminal CCA addition
TI82_RS07185	COG0714	Associated with various cellular activities
TI82_RS07210	COG0435	Glutathione S-transferase
TI82_RS07215	COG3047	cAMP biosynthetic process
TI82_RS07220	COG1051	belongs to the nudix hydrolase family
TI82_RS07235	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
TI82_RS07240	COG0512	Glutamine amidotransferase of anthranilate synthase
TI82_RS07240	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
TI82_RS07250	COG1522	sequence-specific DNA binding
TI82_RS07280	COG4176	ABC-type proline glycine betaine transport system permease component
TI82_RS07285	COG4175	Glycine betaine
TI82_RS07290	COG4608	Belongs to the ABC transporter superfamily
TI82_RS07295	COG0444	Belongs to the ABC transporter superfamily
TI82_RS07300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
TI82_RS07305	COG0601	transmembrane transport
TI82_RS07310	COG0747	negative chemotaxis
TI82_RS07315	COG0747	negative chemotaxis
TI82_RS07320	COG0747	negative chemotaxis
TI82_RS07425	COG1177	transmembrane transport
TI82_RS07430	COG1176	ABC-type spermidine putrescine transport system, permease component I
TI82_RS07435	COG3842	ATPase activity
TI82_RS07450	COG2224	Isocitrate lyase
TI82_RS07465	COG1028	Short-chain dehydrogenase reductase Sdr
TI82_RS07470	COG1028	Short-chain dehydrogenase reductase Sdr
TI82_RS07485	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
TI82_RS07500	COG1461	Dihydroxyacetone kinase
TI82_RS07505	COG2376	Dihydroxyacetone kinase
TI82_RS07510	COG1461	Dihydroxyacetone kinase
TI82_RS07515	COG2376	Dihydroxyacetone kinase
TI82_RS07520	COG1028	Short-chain dehydrogenase reductase Sdr
TI82_RS07525	COG1879	ABC-type sugar transport system periplasmic component
TI82_RS07530	COG1172	Belongs to the binding-protein-dependent transport system permease family
TI82_RS07535	COG1129	ABC transporter
TI82_RS07545	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
TI82_RS07595	COG1012	belongs to the aldehyde dehydrogenase family
TI82_RS07620	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
TI82_RS07635	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TI82_RS07640	COG0564	pseudouridine synthase activity
TI82_RS07660	COG2202	Pas domain
TI82_RS07660	COG3920	Histidine kinase
TI82_RS07670	COG0784	Response regulator, receiver
TI82_RS07685	COG3920	Histidine kinase
TI82_RS07715	COG0848	biopolymer transport protein
TI82_RS07735	COG4591	ABC-type transport system involved in lipoprotein release permease component
TI82_RS07735	COG1136	(ABC) transporter
TI82_RS07740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
TI82_RS07745	COG3293	Transposase
TI82_RS07760	COG1522	sequence-specific DNA binding
TI82_RS07780	COG0477	Major facilitator Superfamily
TI82_RS07800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
TI82_RS07810	COG0385	Bile acid
TI82_RS07825	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
TI82_RS07845	COG2885	chlorophyll binding
TI82_RS07860	COG0848	biopolymer transport protein
TI82_RS07915	COG0483	inositol monophosphate 1-phosphatase activity
TI82_RS07930	COG1132	(ABC) transporter
TI82_RS07960	COG1253	flavin adenine dinucleotide binding
TI82_RS07965	COG1692	metallophosphoesterase
TI82_RS08030	COG1028	Short-chain dehydrogenase reductase Sdr
TI82_RS08030	COG3321	synthase
TI82_RS08030	COG0604	alcohol dehydrogenase
TI82_RS08060	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
TI82_RS08070	COG0457	Tetratricopeptide repeat
TI82_RS08075	COG0469	pyruvate kinase activity
TI82_RS08095	COG0488	(ABC) transporter
TI82_RS08130	COG2258	MOSC domain
TI82_RS08135	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
TI82_RS08140	COG1329	Transcriptional regulator
TI82_RS08145	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
TI82_RS08160	COG0183	Belongs to the thiolase family
TI82_RS08180	COG0142	geranyltranstransferase activity
TI82_RS08190	COG1028	Short-chain dehydrogenase reductase Sdr
TI82_RS08195	COG0738	Major facilitator superfamily
TI82_RS08200	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
TI82_RS08235	COG0559	Belongs to the binding-protein-dependent transport system permease family
TI82_RS08310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
TI82_RS08320	COG5425	PFAM Usg family protein
TI82_RS08340	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
TI82_RS08340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
TI82_RS08355	COG2270	Major facilitator Superfamily
TI82_RS08370	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
TI82_RS08375	COG1704	LemA family
TI82_RS08385	COG0287	Prephenate dehydrogenase
TI82_RS08385	COG1605	Chorismate mutase
TI82_RS08390	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
TI82_RS08400	COG0288	reversible hydration of carbon dioxide
TI82_RS08440	COG0793	Belongs to the peptidase S41A family
TI82_RS08460	COG0799	negative regulation of ribosome biogenesis
TI82_RS08525	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
TI82_RS08580	COG0739	heme binding
TI82_RS08585	COG1376	ErfK ybiS ycfS ynhG family protein
TI82_RS08600	COG2890	protein-(glutamine-N5) methyltransferase activity
TI82_RS08615	COG0527	aspartate kinase activity
TI82_RS08645	COG1040	competence protein
TI82_RS08650	COG2226	methyltransferase
TI82_RS08705	COG2264	protein methyltransferase activity
TI82_RS08710	COG0697	spore germination
TI82_RS08725	COG0004	ammonium transporteR
TI82_RS08730	COG1946	Acyl-CoA thioesterase
TI82_RS08735	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TI82_RS08780	COG1953	Uracil, thiamine, allantoin
TI82_RS08840	COG1280	lysine exporter protein (LysE YggA)
TI82_RS08850	COG0508	dehydrogenase complex catalyzes the overall conversion of
TI82_RS08860	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
TI82_RS08875	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
TI82_RS08890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
TI82_RS08895	COG0552	protein localization to endoplasmic reticulum
TI82_RS08920	COG0494	nUDIX hydrolase
TI82_RS08935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
TI82_RS08960	COG2194	sulfuric ester hydrolase activity
TI82_RS08985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
TI82_RS08990	COG0765	amino acid transport
TI82_RS08995	COG0765	amino acid transport
TI82_RS09015	COG1126	abc transporter atp-binding protein
TI82_RS09025	COG1802	Transcriptional regulator
TI82_RS09030	COG0252	asparaginase activity
TI82_RS09055	COG1250	3-hydroxyacyl-CoA dehydrogenase
TI82_RS09060	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
TI82_RS09065	COG2086	electron transfer activity
TI82_RS09075	COG0720	synthase
TI82_RS09080	COG0602	queuosine metabolic process
TI82_RS09095	COG0300	oxidoreductase activity
TI82_RS09110	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
TI82_RS09140	COG2226	methyltransferase
TI82_RS09150	COG0287	Prephenate dehydrogenase
TI82_RS09175	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
TI82_RS09195	COG2884	Cell division ATP-binding protein ftsE
TI82_RS09210	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
TI82_RS09265	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
TI82_RS09280	COG0789	Transcriptional regulator
TI82_RS09285	COG2217	Heavy metal translocating P-type atpase
TI82_RS09320	COG4536	flavin adenine dinucleotide binding
TI82_RS09360	COG0523	cobalamin synthesis protein
TI82_RS09365	COG1686	Belongs to the peptidase S11 family
TI82_RS09370	COG1473	amidohydrolase
TI82_RS09380	COG1028	Short-chain dehydrogenase reductase Sdr
TI82_RS09400	COG1028	Short-chain dehydrogenase reductase Sdr
TI82_RS09410	COG1012	belongs to the aldehyde dehydrogenase family
TI82_RS09415	COG1024	Enoyl-CoA hydratase
TI82_RS09440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
TI82_RS09450	COG4120	Belongs to the binding-protein-dependent transport system permease family
TI82_RS09455	COG1122	ATPase activity
TI82_RS09490	COG1331	Highly conserved protein containing a thioredoxin domain
TI82_RS09495	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
TI82_RS09505	COG1981	membrane
TI82_RS09530	COG0237	dephospho-CoA kinase activity
TI82_RS09550	COG4395	Tim44
TI82_RS09560	COG2840	Smr protein MutS2
TI82_RS09565	COG1396	sequence-specific DNA binding
TI82_RS09630	COG0745	RESPONSE REGULATOR receiver
TI82_RS09635	COG2205	protein histidine kinase activity
TI82_RS09645	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
TI82_RS09645	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
TI82_RS09650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
TI82_RS09660	COG2205	protein histidine kinase activity
TI82_RS09665	COG3178	'Phosphotransferase
TI82_RS09670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
TI82_RS09675	COG2887	Belongs to the helicase family. UvrD subfamily
TI82_RS09680	COG1074	ATP-dependent DNA helicase activity
TI82_RS09690	COG0285	dihydrofolate synthase activity
TI82_RS09720	COG1434	Gram-negative-bacterium-type cell wall biogenesis
TI82_RS09735	COG3135	benzoate transporter
TI82_RS09750	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
TI82_RS09800	COG3963	phosphatidate phosphatase activity
TI82_RS09815	COG3386	PFAM SMP-30 Gluconolaconase
TI82_RS09825	COG0606	chelatase, subunit chli
TI82_RS09835	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
TI82_RS09840	COG2832	Protein of unknown function (DUF454)
TI82_RS09845	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
TI82_RS09850	COG0573	inorganic phosphate transmembrane transporter activity
TI82_RS09860	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
TI82_RS09865	COG0704	Plays a role in the regulation of phosphate uptake
TI82_RS09870	COG0745	RESPONSE REGULATOR receiver
TI82_RS09875	COG3773	Cell wall hydrolase
TI82_RS09885	COG2309	aminopeptidase activity
TI82_RS09890	COG0783	Belongs to the Dps family
TI82_RS09900	COG0456	acetyltransferase
TI82_RS09935	COG1396	sequence-specific DNA binding
TI82_RS09940	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
TI82_RS09955	COG0195	Participates in both transcription termination and antitermination
TI82_RS09955	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
TI82_RS09990	COG2813	Specifically methylates the guanine in position
TI82_RS09995	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
TI82_RS10035	COG0791	NLP P60 protein
TI82_RS10045	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
TI82_RS10060	COG1024	Enoyl-CoA hydratase
TI82_RS10230	COG0539	negative regulation of cytoplasmic translation
TI82_RS10650	COG3459	Glycosyltransferase 36 associated
TI82_RS10665	COG3459	Glycosyltransferase 36 associated
TI82_RS10745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TI82_RS10745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TI82_RS10750	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TI82_RS10750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
TI82_RS10840	COG0728	peptidoglycan biosynthetic process
TI82_RS11020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
TI82_RS11020	COG1648	precorrin-2 dehydrogenase activity
TI82_RS11155	COG5265	(ABC) transporter
TI82_RS11190	COG2217	Heavy metal translocating P-type atpase
TI82_RS11430	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TI82_RS11460	COG0167	dihydroorotate dehydrogenase activity
TI82_RS11510	COG0318	PFAM AMP-dependent synthetase and ligase
TI82_RS11580	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
TI82_RS11805	COG1529	Aldehyde oxidase and xanthine dehydrogenase
TI82_RS11950	COG3773	Cell wall hydrolase
TI82_RS12060	COG0751	glycine-tRNA ligase activity
TI82_RS12065	COG0751	glycine-tRNA ligase activity
TI82_RS12175	COG1741	Belongs to the pirin family
TI82_RS12220	COG5265	(ABC) transporter
TI82_RS12370	COG5001	Diguanylate cyclase
TI82_RS12475	COG1196	nuclear chromosome segregation
TI82_RS12740	COG2807	transmembrane transport
TI82_RS13005	COG0308	aminopeptidase N
TI82_RS13290	COG0488	(ABC) transporter
TI82_RS13735	COG2873	o-acetylhomoserine
TI82_RS14455	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
TI82_RS14595	COG0084	hydrolase, TatD family'
TI82_RS14855	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
TI82_RS15115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
TI82_RS15350	COG0658	competence protein
TI82_RS15350	COG2333	competence protein COMEC
TI82_RS15395	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane