locus-tag	class	description
BCC_RS00005	COG0445	tRNA wobble uridine modification
BCC_RS00040	COG0445	tRNA wobble uridine modification
BCC_RS00045	COG0187	DNA topoisomerase II activity
BCC_RS00050	COG0592	DNA-directed DNA polymerase activity
BCC_RS00055	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BCC_RS00060	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BCC_RS00070	COG0706	membrane insertase activity
BCC_RS00075	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BCC_RS00085	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BCC_RS00090	COG0459	protein refolding
BCC_RS00095	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BCC_RS00100	COG1484	DNA-dependent DNA replication
BCC_RS00105	COG0742	ribosomal rna small subunit methyltransferase
BCC_RS00110	COG0552	protein localization to endoplasmic reticulum
BCC_RS00115	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BCC_RS00120	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BCC_RS00125	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
BCC_RS00130	COG0085	RNA polymerase activity
BCC_RS00135	COG0222	ribosome binding
BCC_RS00140	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BCC_RS00145	COG0081	regulation of translation
BCC_RS00150	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BCC_RS00155	COG0250	Participates in transcription elongation, termination and antitermination
BCC_RS00160	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BCC_RS00185	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BCC_RS00195	COG0137	argininosuccinate synthase activity
BCC_RS00200	COG0165	Argininosuccinate lyase
BCC_RS00205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BCC_RS00210	COG0358	DNA primase activity
BCC_RS00215	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BCC_RS00220	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BCC_RS00225	COG0617	tRNA 3'-terminal CCA addition
BCC_RS00235	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BCC_RS00250	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BCC_RS00275	COG1157	protein secretion by the type III secretion system
BCC_RS00300	COG1987	bacterial-type flagellum assembly
BCC_RS00305	COG1684	flagellar biosynthetic protein fliR
BCC_RS00310	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BCC_RS00315	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BCC_RS00320	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BCC_RS00325	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BCC_RS00330	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BCC_RS00335	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BCC_RS00340	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BCC_RS00345	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
BCC_RS00350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BCC_RS00355	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
BCC_RS00360	COG2840	Smr protein MutS2
BCC_RS00365	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BCC_RS00370	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
BCC_RS00375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
BCC_RS00380	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BCC_RS00380	COG0131	Imidazoleglycerol-phosphate dehydratase
BCC_RS00385	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
BCC_RS00390	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
BCC_RS00395	COG0107	imidazoleglycerol-phosphate synthase activity
BCC_RS00400	COG0140	phosphoribosyl-ATP diphosphatase activity
BCC_RS00400	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BCC_RS00405	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
BCC_RS00415	COG0037	tRNA processing
BCC_RS00430	COG0316	Belongs to the HesB IscA family
BCC_RS00435	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
BCC_RS00440	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
BCC_RS00450	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BCC_RS00455	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BCC_RS00460	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BCC_RS00465	COG0072	phenylalanine-tRNA ligase activity
BCC_RS00465	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BCC_RS00470	COG0776	regulation of translation
BCC_RS00475	COG0751	glycine-tRNA ligase activity
BCC_RS00480	COG0752	glycyl-tRNA synthetase alpha subunit
BCC_RS00490	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
BCC_RS00495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BCC_RS00500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BCC_RS00505	COG0505	Belongs to the CarA family
BCC_RS00510	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BCC_RS00515	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BCC_RS00520	COG0268	Binds directly to 16S ribosomal RNA
BCC_RS00525	COG0484	heat shock protein binding
BCC_RS00530	COG0443	Heat shock 70 kDa protein
BCC_RS00535	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BCC_RS00540	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BCC_RS00545	COG0649	NAD binding
BCC_RS00550	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
BCC_RS00555	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
BCC_RS00560	COG1034	ATP synthesis coupled electron transport
BCC_RS00565	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BCC_RS00570	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BCC_RS00580	COG0713	ATP synthesis coupled electron transport
BCC_RS00585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BCC_RS00590	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BCC_RS00595	COG1007	ATP synthesis coupled electron transport
BCC_RS00600	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BCC_RS00605	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BCC_RS00610	COG2890	protein-(glutamine-N5) methyltransferase activity
BCC_RS00615	COG2912	Transglutaminase-like superfamily
BCC_RS00620	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BCC_RS00625	COG0280	phosphate acetyltransferase
BCC_RS00625	COG0857	belongs to the CobB CobQ family
BCC_RS00630	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BCC_RS00635	COG0450	alkyl hydroperoxide reductase
BCC_RS00640	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BCC_RS00650	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
BCC_RS00655	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BCC_RS00660	COG0193	aminoacyl-tRNA hydrolase activity
BCC_RS00665	COG0012	GTP binding
BCC_RS00670	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BCC_RS00675	COG0083	homoserine kinase activity
BCC_RS00680	COG0460	homoserine dehydrogenase
BCC_RS00680	COG0527	aspartate kinase activity
BCC_RS00695	COG0653	protein targeting
BCC_RS00700	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
BCC_RS00705	COG0508	dehydrogenase complex catalyzes the overall conversion of
BCC_RS00710	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
BCC_RS00715	COG0316	Belongs to the HesB IscA family
BCC_RS00720	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BCC_RS00725	COG0849	cell division
BCC_RS00730	COG0275	rRNA processing
BCC_RS00735	COG0440	acetolactate synthase activity
BCC_RS00740	COG0028	Belongs to the TPP enzyme family
BCC_RS00745	COG2171	N-acyltransferase activity
BCC_RS00750	COG0024	Methionine aminopeptidase
BCC_RS00755	COG0052	Belongs to the universal ribosomal protein uS2 family
BCC_RS00760	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
BCC_RS00765	COG0528	UMP kinase activity
BCC_RS00770	COG0233	cytoplasmic translational termination
BCC_RS00775	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BCC_RS00785	COG0587	DNA-directed DNA polymerase activity
BCC_RS00790	COG0442	prolyl-tRNA aminoacylation
BCC_RS00795	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BCC_RS00800	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BCC_RS00805	COG0018	arginyl-trna synthetase
BCC_RS00825	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
BCC_RS00835	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BCC_RS00845	COG0590	tRNA wobble adenosine to inosine editing
BCC_RS00855	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BCC_RS00860	COG0571	ribonuclease III activity
BCC_RS00865	COG0681	Belongs to the peptidase S26 family
BCC_RS00870	COG0481	GTPase activity
BCC_RS00875	COG0482	sulfurtransferase activity
BCC_RS00880	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BCC_RS00885	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
BCC_RS00890	COG0321	lipoyl(octanoyl) transferase activity
BCC_RS00895	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
BCC_RS00900	COG0616	signal peptide processing
BCC_RS00905	COG1607	acyl-coa hydrolase
BCC_RS00920	COG0483	inositol monophosphate 1-phosphatase activity
BCC_RS00925	COG0820	rRNA (adenine-C2-)-methyltransferase activity
BCC_RS00930	COG0124	histidyl-tRNA synthetase
BCC_RS00935	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BCC_RS00940	COG2706	6-phosphogluconolactonase activity
BCC_RS00945	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BCC_RS00950	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BCC_RS00955	COG0716	FMN binding
BCC_RS00965	COG0567	Dehydrogenase, E1 component
BCC_RS00970	COG0508	dehydrogenase complex catalyzes the overall conversion of
BCC_RS00975	COG0588	phosphoglycerate mutase activity
BCC_RS00980	COG0205	6-phosphofructokinase activity
BCC_RS00985	COG0149	triose-phosphate isomerase activity
BCC_RS00990	COG0776	regulation of translation
BCC_RS00995	COG0539	negative regulation of cytoplasmic translation
BCC_RS01000	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BCC_RS01005	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BCC_RS01015	COG0492	ferredoxin-NADP+ reductase activity
BCC_RS01020	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BCC_RS01030	COG0217	transcriptional regulatory protein
BCC_RS01035	COG0469	pyruvate kinase activity
BCC_RS01040	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
BCC_RS01045	COG0501	Belongs to the peptidase M48B family
BCC_RS01055	COG1214	PFAM Peptidase M22, glycoprotease
BCC_RS01060	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
BCC_RS01065	COG2894	cell division
BCC_RS01070	COG0850	regulation of cytokinetic process
BCC_RS01075	COG2813	Specifically methylates the guanine in position
BCC_RS01100	COG4787	bacterial-type flagellum-dependent cell motility
BCC_RS01110	COG1706	bacterial-type flagellum-dependent cell motility
BCC_RS01115	COG0564	pseudouridine synthase activity
BCC_RS01120	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BCC_RS01125	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BCC_RS01130	COG1028	Short-chain dehydrogenase reductase Sdr
BCC_RS01135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BCC_RS01140	COG0470	DNA polymerase III
BCC_RS01145	COG0084	hydrolase, TatD family'
BCC_RS01150	COG0017	Asparaginyl-tRNA synthetase
BCC_RS01155	COG1054	Belongs to the UPF0176 family
BCC_RS01160	COG0525	valine-tRNA ligase activity
BCC_RS01165	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BCC_RS01170	COG0251	oxidation-reduction process
BCC_RS01175	COG0513	Belongs to the DEAD box helicase family
BCC_RS01180	COG1185	polyribonucleotide nucleotidyltransferase activity
BCC_RS01185	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BCC_RS01190	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
BCC_RS01195	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
BCC_RS01200	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BCC_RS01205	COG0195	Participates in both transcription termination and antitermination
BCC_RS01215	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BCC_RS01220	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
BCC_RS01225	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BCC_RS01230	COG5007	Belongs to the BolA IbaG family
BCC_RS01235	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BCC_RS01240	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BCC_RS01245	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
BCC_RS01255	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BCC_RS01260	COG0077	Prephenate dehydratase
BCC_RS01260	COG1605	Chorismate mutase
BCC_RS01265	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BCC_RS01270	COG0228	four-way junction DNA binding
BCC_RS01275	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BCC_RS01280	COG0336	Belongs to the RNA methyltransferase TrmD family
BCC_RS01285	COG0335	large ribosomal subunit rRNA binding
BCC_RS01290	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BCC_RS01305	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BCC_RS01310	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
BCC_RS01325	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
BCC_RS01355	COG0148	phosphopyruvate hydratase activity
BCC_RS01370	COG1217	gtp-binding protein TYPA
BCC_RS01375	COG0354	folic acid binding
BCC_RS01380	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
BCC_RS01385	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BCC_RS01390	COG0019	diaminopimelate decarboxylase activity
BCC_RS01395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BCC_RS01400	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
BCC_RS01405	COG0495	leucyl-tRNA aminoacylation
BCC_RS01415	COG0425	Belongs to the sulfur carrier protein TusA family
BCC_RS01420	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BCC_RS01425	COG0126	phosphoglycerate kinase activity
BCC_RS01430	COG0191	fructose-bisphosphate aldolase activity
BCC_RS01435	COG0668	transmembrane transport
BCC_RS01440	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
BCC_RS01445	COG1074	ATP-dependent DNA helicase activity
BCC_RS01450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BCC_RS01460	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BCC_RS01470	COG0109	protoheme IX farnesyltransferase activity
BCC_RS01480	COG1845	cytochrome c oxidase, subunit III
BCC_RS01485	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
BCC_RS01490	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
BCC_RS01500	COG0740	serine-type endopeptidase activity
BCC_RS01505	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BCC_RS01510	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BCC_RS01515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BCC_RS01525	COG1132	(ABC) transporter
BCC_RS01530	COG1132	(ABC) transporter
BCC_RS01535	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BCC_RS01540	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BCC_RS01545	COG0326	Molecular chaperone. Has ATPase activity
BCC_RS01550	COG0563	adenylate kinase activity
BCC_RS01560	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BCC_RS01565	COG0215	cysteine-tRNA ligase activity
BCC_RS01570	COG2921	Belongs to the UPF0250 family
BCC_RS01575	COG1278	Cold shock
BCC_RS01595	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BCC_RS01600	COG0242	peptide deformylase activity
BCC_RS01610	COG0203	ribosomal protein L17
BCC_RS01615	COG0202	RNA polymerase activity
BCC_RS01620	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
BCC_RS01625	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BCC_RS01630	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
BCC_RS01635	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BCC_RS01640	COG0201	protein transport
BCC_RS01645	COG0200	Binds to the 23S rRNA
BCC_RS01650	COG1841	ribosomal large subunit assembly
BCC_RS01655	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BCC_RS01665	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BCC_RS01670	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BCC_RS01675	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BCC_RS01680	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BCC_RS01685	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BCC_RS01690	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BCC_RS01695	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BCC_RS01700	COG0255	Belongs to the universal ribosomal protein uL29 family
BCC_RS01705	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BCC_RS01710	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BCC_RS01715	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BCC_RS01720	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BCC_RS01725	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
BCC_RS01735	COG0088	Forms part of the polypeptide exit tunnel
BCC_RS01740	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BCC_RS01745	COG0051	transcription antitermination factor activity, RNA binding
BCC_RS01750	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BCC_RS01755	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
BCC_RS01760	COG0049	tRNA binding
BCC_RS01765	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BCC_RS01780	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
BCC_RS01785	COG0180	Tryptophanyl-tRNA synthetase
BCC_RS01790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BCC_RS01795	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
BCC_RS01800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BCC_RS01810	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
BCC_RS01815	COG0596	Alpha beta hydrolase
BCC_RS01820	COG0629	single-stranded DNA binding
BCC_RS01835	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
BCC_RS01840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BCC_RS01845	COG1194	a g-specific adenine glycosylase
BCC_RS01850	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
BCC_RS01855	COG2925	Exonuclease
BCC_RS01875	COG0359	binds to the 23S rRNA
BCC_RS01880	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BCC_RS01885	COG0360	Binds together with S18 to 16S ribosomal RNA
BCC_RS01890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
BCC_RS01895	COG0166	Belongs to the GPI family
BCC_RS01900	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
BCC_RS01910	COG0254	rRNA binding
BCC_RS01915	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
BCC_RS01920	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BCC_RS01930	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
BCC_RS01940	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BCC_RS01945	COG1965	Belongs to the frataxin family
BCC_RS01965	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BCC_RS01970	COG3118	belongs to the thioredoxin family
BCC_RS01975	COG0210	DNA helicase
BCC_RS01980	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BCC_RS01985	COG0129	dihydroxy-acid dehydratase activity
BCC_RS01995	COG1104	cysteine desulfurase activity
BCC_RS02000	COG0822	iron-sulfur transferase activity
BCC_RS02015	COG0633	Ferredoxin
BCC_RS02050	COG1766	The M ring may be actively involved in energy transduction
BCC_RS02065	COG0736	holo-[acyl-carrier-protein] synthase activity
BCC_RS02070	COG1253	flavin adenine dinucleotide binding
BCC_RS02075	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
BCC_RS02075	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity