locus-tag	class	description
D9V81_RS00010	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
D9V81_RS00015	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
D9V81_RS00025	ENOG4107Z6K	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
D9V81_RS00030	ENOG4107S15	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
D9V81_RS00035	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
D9V81_RS00045	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
D9V81_RS00050	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
D9V81_RS00055	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
D9V81_RS00060	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
D9V81_RS00065	ENOG4105VG0	50S ribosomal protein l34
D9V81_RS00070	ENOG4105NVJ	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
D9V81_RS00075	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
D9V81_RS00090	ENOG4105K5Y	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)
D9V81_RS00100	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
D9V81_RS00105	ENOG4106CVF	DNA replication protein
D9V81_RS00110	ENOG4106H78	methyltransferase
D9V81_RS00115	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
D9V81_RS00120	ENOG4105DEK	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
D9V81_RS00125	ENOG4105DSS	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)
D9V81_RS00130	ENOG4105DC1	bifunctional purine biosynthesis protein purh
D9V81_RS00140	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
D9V81_RS00145	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
D9V81_RS00150	ENOG4105KBC	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
D9V81_RS00155	ENOG4108VZM	50s ribosomal protein L10
D9V81_RS00160	ENOG4105C64	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)
D9V81_RS00170	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
D9V81_RS00200	ENOG4105SYT	Methylenetetrahydrofolate reductase
D9V81_RS00215	ENOG4105CH7	arginosuccinase
D9V81_RS00220	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
D9V81_RS00225	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
D9V81_RS00230	ENOG4105VCC	30S ribosomal protein S21
D9V81_RS00235	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
D9V81_RS00245	ENOG4105C5Y	PTS System
D9V81_RS00250	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
D9V81_RS00255	ENOG4105KZ7	phosphocarrier protein hpr
D9V81_RS00260	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
D9V81_RS00275	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
D9V81_RS00280	ENOG4105C1F	The M ring may be actively involved in energy transduction (By similarity)
D9V81_RS00285	ENOG4105CS3	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)
D9V81_RS00295	ENOG4108JIR	Flagellum-specific ATP synthase
D9V81_RS00310	ENOG4105DD5	Flagellar motor switch protein
D9V81_RS00315	ENOG4105CN7	Flagellar biosynthetic protein FliP
D9V81_RS00320	ENOG4105VS8	Flagellar biosynthetic protein fliq
D9V81_RS00325	ENOG4105D19	Role in flagellar biosynthesis (By similarity)
D9V81_RS00330	ENOG4105W0E	50S ribosomal protein L33
D9V81_RS00335	ENOG4105KDC	50s ribosomal protein l28
D9V81_RS00340	ENOG4105F0N	pyrophosphate phospho-hydrolase
D9V81_RS00350	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
D9V81_RS00355	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
D9V81_RS00365	ENOG4105CV1	Transketolase (EC 2.2.1.1)
D9V81_RS00370	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
D9V81_RS00385	ENOG4108DG9	Smr protein MutS2
D9V81_RS00395	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
D9V81_RS00405	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
D9V81_RS00410	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
D9V81_RS00415	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
D9V81_RS00420	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
D9V81_RS00425	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
D9V81_RS00430	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
D9V81_RS00440	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
D9V81_RS00450	ENOG4108R6K	riboflavin synthase, subunit alpha
D9V81_RS00460	ENOG4108Z4V	iron-sulfur cluster assembly
D9V81_RS00465	ENOG4105E99	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)
D9V81_RS00470	ENOG4105C22	threonyL-tRNA synthetase
D9V81_RS00475	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
D9V81_RS00480	ENOG41082NX	50s ribosomal protein l35
D9V81_RS00490	ENOG4105CSS	phenylalanyl-tRNA synthetase (alpha subunit)
D9V81_RS00495	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
D9V81_RS00500	ENOG4105C38	Glycyl-tRNA synthetase beta subunit
D9V81_RS00505	ENOG4108HMW	glycyl-tRNA synthetase, alpha subunit
D9V81_RS00510	ENOG4105QAV	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
D9V81_RS00515	ENOG4108KF1	Membrane
D9V81_RS00520	ENOG4105D1X	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)
D9V81_RS00525	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
D9V81_RS00530	ENOG4105CU6	carbamoyl-phosphate synthetase ammonia chain
D9V81_RS00535	ENOG4105C1M	carbamoyl-phosphate synthetase glutamine chain
D9V81_RS00540	ENOG4105DUK	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)
D9V81_RS00545	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
D9V81_RS00550	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
D9V81_RS00555	ENOG4105KQV	Binds directly to 16S ribosomal RNA (By similarity)
D9V81_RS00560	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
D9V81_RS00570	ENOG4105KWU	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D9V81_RS00575	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D9V81_RS00580	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D9V81_RS00585	ENOG4105GKE	subunit e
D9V81_RS00590	ENOG4107QIZ	NADH dehydrogenase
D9V81_RS00595	ENOG4107R0R	NADH dehydrogenase subunit g
D9V81_RS00600	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
D9V81_RS00605	ENOG4105P3U	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D9V81_RS00610	ENOG4107UFS	subunit j
D9V81_RS00620	ENOG4105D65	subunit l
D9V81_RS00625	ENOG4105C8S	subunit m
D9V81_RS00630	ENOG4105CNR	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
D9V81_RS00635	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
D9V81_RS00640	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
D9V81_RS00650	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
D9V81_RS00655	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
D9V81_RS00660	ENOG4105C6K	Malic enzyme
D9V81_RS00665	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
D9V81_RS00670	ENOG4105G4C	Periplasmic ligand-binding sensor protein
D9V81_RS00675	ENOG4105D3R	alkyl hydroperoxide reductase
D9V81_RS00680	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D9V81_RS00685	ENOG4105F91	Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)
D9V81_RS00695	ENOG4105M2J	Glutaredoxin
D9V81_RS00700	ENOG4105DH5	Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity)
D9V81_RS00705	ENOG4105C3G	gtp-binding protein
D9V81_RS00710	ENOG4105D98	threonine synthase
D9V81_RS00715	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
D9V81_RS00720	ENOG4105CFH	Aspartokinase
D9V81_RS00725	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
D9V81_RS00735	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
D9V81_RS00740	ENOG4105DAQ	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)
D9V81_RS00745	ENOG4107QSN	dihydrolipoamide acetyltransferase
D9V81_RS00750	ENOG4107QN2	dihydrolipoyl dehydrogenase
D9V81_RS00755	ENOG4108YX9	iron--sulfur cluster insertion protein erpA
D9V81_RS00760	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
D9V81_RS00765	ENOG4105CIT	This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)
D9V81_RS00770	ENOG4105CGJ	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)
D9V81_RS00775	ENOG4108ZP8	Acetolactate synthase small subunit
D9V81_RS00780	ENOG4105C7K	acetolactate synthase
D9V81_RS00785	ENOG4105DMJ	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity)
D9V81_RS00790	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
D9V81_RS00795	ENOG4105CE9	30S ribosomal protein S2
D9V81_RS00805	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
D9V81_RS00815	ENOG4105E1Z	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D9V81_RS00820	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
D9V81_RS00825	ENOG4105C0B	DNA polymerase III (alpha subunit)
D9V81_RS00835	ENOG4105D00	flagellar biosynthetic protein flhB
D9V81_RS00840	ENOG4105D7B	Flagellar biosynthesis protein flha
D9V81_RS00865	ENOG4107RZZ	dna polymerase iii epsilon subunit
D9V81_RS00875	ENOG4105DYA	Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity)
D9V81_RS00880	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D9V81_RS00890	ENOG4108Z6B	deaminase
D9V81_RS00895	ENOG4105KJV	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
D9V81_RS00900	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
D9V81_RS00910	ENOG4105C3F	Signal peptidase i
D9V81_RS00920	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
D9V81_RS00925	ENOG4107QTF	adenylosuccinate lyase
D9V81_RS00930	ENOG4105CSJ	Enoyl- acyl-carrier-protein reductase NADH
D9V81_RS00935	ENOG4108IEC	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)
D9V81_RS00940	ENOG4105EZI	multiple antibiotic resistance (MarC)-related protein
D9V81_RS00945	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
D9V81_RS00950	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
D9V81_RS00955	ENOG4107T1C	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity)
D9V81_RS00960	ENOG4105NAU	thioesterase Superfamily protein
D9V81_RS00975	ENOG4105DK0	Indole-3-glycerol phosphate synthase
D9V81_RS00990	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
D9V81_RS00995	ENOG4105CUT	histidyl-tRNA synthetase
D9V81_RS01000	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
D9V81_RS01005	ENOG4105E78	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)
D9V81_RS01010	ENOG4105CZF	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)
D9V81_RS01015	ENOG4108F0W	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)
D9V81_RS01020	ENOG4105HHQ	6-phosphogluconolactonase (EC 3.1.1.31)
D9V81_RS01025	ENOG4108JA2	transcriptioN-repair coupling factor
D9V81_RS01030	ENOG4105C17	glyceraldehyde-3-phosphate dehydrogenase
D9V81_RS01035	ENOG4105MHQ	Low-potential electron donor to a number of redox enzymes (By similarity)
D9V81_RS01040	ENOG4107QNR	UPF0135 protein
D9V81_RS01045	ENOG4105C7P	2-oxoglutarate dehydrogenase, E1
D9V81_RS01050	ENOG4105C7S	Dehydrogenase
D9V81_RS01055	ENOG4105DKJ	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
D9V81_RS01060	ENOG4105CTQ	phosphohexokinase
D9V81_RS01065	ENOG4105CP7	Triose-phosphate isomerase
D9V81_RS01070	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
D9V81_RS01080	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
D9V81_RS01095	ENOG4105C3M	thioredoxin reductase
D9V81_RS01100	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
D9V81_RS01110	ENOG4105CA9	Pyruvate kinase
D9V81_RS01115	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
D9V81_RS01120	ENOG4105D0M	Protease HtpX homolog
D9V81_RS01125	ENOG4105EE5	Membrane protein terC
D9V81_RS01130	ENOG41072GX	Peptidase M22 Glycoprotease
D9V81_RS01155	ENOG4105VJP	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)
D9V81_RS01160	ENOG4107QMS	site-determining protein
D9V81_RS01170	ENOG4105D8J	Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)
D9V81_RS01190	ENOG4105CJR	Integral membrane protein (MviN
D9V81_RS01195	ENOG4105EI2	Pseudouridine synthase
D9V81_RS01200	ENOG4105VGS	50s ribosomal protein l32
D9V81_RS01205	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
D9V81_RS01210	ENOG4105CHR	reductase
D9V81_RS01220	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
D9V81_RS01225	ENOG4107QRG	dna polymerase iii
D9V81_RS01230	ENOG4105F8V	Hydrolase, tatD family
D9V81_RS01235	ENOG4105CI1	PTS System
D9V81_RS01245	ENOG4105C5S	asparaginyl-tRNA synthetase
D9V81_RS01250	ENOG4105CA4	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)
D9V81_RS01255	ENOG4105DBV	ornithine carbamoyltransferase
D9V81_RS01260	ENOG4105KME	endoribonuclease L-psp
D9V81_RS01265	ENOG4105C1J	atp-dependent rna helicase
D9V81_RS01270	ENOG4105C62	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
D9V81_RS01275	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
D9V81_RS01280	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
D9V81_RS01285	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
D9V81_RS01290	ENOG4107QHU	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
D9V81_RS01295	ENOG4105CHV	Transcription elongation factor NusA
D9V81_RS01310	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
D9V81_RS01315	ENOG4105F7M	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)
D9V81_RS01325	ENOG4105VFK	BolA family
D9V81_RS01340	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D9V81_RS01345	ENOG4108UJD	30S ribosomal protein S9
D9V81_RS01355	ENOG4105CQC	Prephenate dehydratase
D9V81_RS01360	ENOG4105CB9	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D9V81_RS01365	ENOG4105K5M	30s ribosomal protein S16
D9V81_RS01370	ENOG4108ZR6	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
D9V81_RS01375	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
D9V81_RS01390	ENOG4105C34	Pseudouridine synthase
D9V81_RS01395	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
D9V81_RS01400	ENOG4105VM8	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity)
D9V81_RS01435	ENOG4105CX6	glutaminyL-tRNA synthetase
D9V81_RS01440	ENOG4105C70	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)
D9V81_RS01445	ENOG4105C2M	dna polymerase I
D9V81_RS01455	ENOG4105CI3	gtp-binding protein typa
D9V81_RS01460	ENOG4106XY2	Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)
D9V81_RS01470	ENOG4105CRK	lysyL-tRNA synthetase
D9V81_RS01475	ENOG4105CU5	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)
D9V81_RS01480	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
D9V81_RS01485	ENOG4105KGE	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
D9V81_RS01490	ENOG4105C8T	Leucyl-tRNA synthetase
D9V81_RS01505	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
D9V81_RS01510	ENOG41076UM	multiple antibiotic resistance (MarC)-related protein
D9V81_RS01515	ENOG4105BZA	Phosphoglycerate kinase
D9V81_RS01520	ENOG4105D2N	Aldolase
D9V81_RS01525	ENOG4105D64	Mechanosensitive ion channel
D9V81_RS01535	ENOG4108UTT	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)
D9V81_RS01540	ENOG4105D1W	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)
D9V81_RS01545	ENOG4107YIM	Involved in the transcription termination process (By similarity)
D9V81_RS01550	ENOG4108Z0T	Part of a sulfur-relay system (By similarity)
D9V81_RS01555	ENOG4105F1R	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)
D9V81_RS01560	ENOG41090KH	cytochrome o ubiquinol oxidase (subunit iv)
D9V81_RS01565	ENOG4107R3R	Cytochrome o ubiquinol oxidase subunit III
D9V81_RS01570	ENOG4105BZ9	Cytochrome C oxidase, subunit I
D9V81_RS01575	ENOG4105E2S	oxidase) subunit II
D9V81_RS01580	ENOG4105M85	Bola protein
D9V81_RS01585	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
D9V81_RS01590	ENOG4105CCQ	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)
D9V81_RS01595	ENOG4105CHN	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)
D9V81_RS01600	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
D9V81_RS01605	ENOG4105BZ1	(ABC) transporter
D9V81_RS01610	ENOG4105BZ1	(ABC) transporter
D9V81_RS01620	ENOG4107QMP	dna polymerase iii subunits gamma and tau
D9V81_RS01625	ENOG4105KDX	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
D9V81_RS01630	ENOG4105CJX	Molecular chaperone. Has ATPase activity (By similarity)
D9V81_RS01645	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
D9V81_RS01650	ENOG4105C8N	cysteinyl-tRNA synthetase
D9V81_RS01655	ENOG4105VEQ	Cold shock protein
D9V81_RS01675	ENOG4105E2X	shikimate dehydrogenase
D9V81_RS01680	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
D9V81_RS01685	ENOG4108Z02	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
D9V81_RS01695	ENOG4108ZT0	50S ribosomal protein l17
D9V81_RS01700	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
D9V81_RS01705	ENOG4105G6W	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)
D9V81_RS01715	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D9V81_RS01720	ENOG41067V7	50S ribosomal protein L36
D9V81_RS01725	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
D9V81_RS01730	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
D9V81_RS01740	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
D9V81_RS01750	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
D9V81_RS01755	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
D9V81_RS01760	ENOG4105VBI	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)
D9V81_RS01765	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D9V81_RS01770	ENOG4105KAR	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)
D9V81_RS01780	ENOG4105K87	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal
D9V81_RS01785	ENOG41083MP	50s ribosomal protein l29
D9V81_RS01790	ENOG4108R70	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)
D9V81_RS01795	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
D9V81_RS01800	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
D9V81_RS01805	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
D9V81_RS01810	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D9V81_RS01815	ENOG41080KG	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
D9V81_RS01825	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
D9V81_RS01830	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
D9V81_RS01835	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
D9V81_RS01845	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
D9V81_RS01850	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
D9V81_RS01855	ENOG4105YKK	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
D9V81_RS01860	ENOG4108ZKU	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)
D9V81_RS01875	ENOG4105C31	Tryptophanyl-tRNA synthetase
D9V81_RS01880	ENOG4105DJV	ribulose-phosphate 3-epimerase
D9V81_RS01885	ENOG4105D49	3-dehydroquinate synthase
D9V81_RS01910	ENOG4107RUK	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity)
D9V81_RS01915	ENOG4108UUM	single-stranded DNA-binding protein
D9V81_RS01920	ENOG4105CDU	Replicative dna helicase
D9V81_RS01925	ENOG4108UJU	UPF0301 protein
D9V81_RS01935	ENOG4105CSA	Coproporphyrinogen iii oxidase
D9V81_RS01940	ENOG4105CZ1	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity)
D9V81_RS01945	ENOG4105CEN	a g-specific adenine glycosylase
D9V81_RS01950	ENOG4105KMG	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)
D9V81_RS01955	ENOG4105CJB	Exodeoxyribonuclease I
D9V81_RS01985	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
D9V81_RS01990	ENOG4105DDQ	anthranilate synthase
D9V81_RS02000	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
D9V81_RS02005	ENOG4107QP8	phosphohexose isomerase
D9V81_RS02010	ENOG4108ZNX	Heat shock protein
D9V81_RS02015	ENOG4108RBP	3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity)
D9V81_RS02030	ENOG4108R5P	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)
D9V81_RS02035	ENOG4105C4N	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)
D9V81_RS02040	ENOG4105DP0	ferredoxin-NADP reductase
D9V81_RS02045	ENOG4105CAP	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)
D9V81_RS02055	ENOG4105FFN	Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity)
D9V81_RS02060	ENOG4105D94	Major Facilitator Superfamily
D9V81_RS02065	ENOG4105E4Z	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)
D9V81_RS02070	ENOG4105XQ6	frataxin-like protein
D9V81_RS02090	ENOG4105C4P	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)
D9V81_RS02095	ENOG4105K63	Thioredoxin
D9V81_RS02100	ENOG4105C4R	Atp-dependent dna helicase
D9V81_RS02105	ENOG4105C6M	Alpha-keto-beta-hydroxylacyl reductoisomerase
D9V81_RS02110	ENOG4105C01	Dihydroxy-acid dehydratase
D9V81_RS02120	ENOG4105C3J	Cysteine desulfurase
D9V81_RS02125	ENOG4107XTC	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins
D9V81_RS02130	ENOG4108ZIT	Ferredoxin, 2FE-2S