locus-tag	class	description
D9V81_RS00010	COG0445	tRNA wobble uridine modification
D9V81_RS00015	COG0356	it plays a direct role in the translocation of protons across the membrane
D9V81_RS00025	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
D9V81_RS00030	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D9V81_RS00035	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
D9V81_RS00045	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D9V81_RS00050	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D9V81_RS00055	COG0187	DNA topoisomerase II activity
D9V81_RS00060	COG0592	DNA-directed DNA polymerase activity
D9V81_RS00065	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D9V81_RS00070	COG0594	ribonuclease P activity
D9V81_RS00075	COG0706	membrane insertase activity
D9V81_RS00090	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D9V81_RS00100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D9V81_RS00105	COG1484	DNA-dependent DNA replication
D9V81_RS00110	COG0742	ribosomal rna small subunit methyltransferase
D9V81_RS00115	COG0552	protein localization to endoplasmic reticulum
D9V81_RS00120	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D9V81_RS00125	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
D9V81_RS00130	COG0138	bifunctional purine biosynthesis protein purh
D9V81_RS00140	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
D9V81_RS00145	COG0085	RNA polymerase activity
D9V81_RS00150	COG0222	ribosome binding
D9V81_RS00155	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
D9V81_RS00160	COG0081	regulation of translation
D9V81_RS00170	COG0250	Participates in transcription elongation, termination and antitermination
D9V81_RS00200	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D9V81_RS00215	COG0165	Argininosuccinate lyase
D9V81_RS00220	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D9V81_RS00225	COG0358	DNA primase activity
D9V81_RS00230	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D9V81_RS00235	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D9V81_RS00245	COG2190	(PTS) system
D9V81_RS00250	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
D9V81_RS00255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
D9V81_RS00260	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D9V81_RS00275	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D9V81_RS00280	COG1766	The M ring may be actively involved in energy transduction
D9V81_RS00285	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9V81_RS00295	COG1157	protein secretion by the type III secretion system
D9V81_RS00310	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D9V81_RS00315	COG1338	Plays a role in the flagellum-specific transport system
D9V81_RS00315	COG3190	flagellar
D9V81_RS00320	COG1987	bacterial-type flagellum assembly
D9V81_RS00325	COG1684	flagellar biosynthetic protein fliR
D9V81_RS00330	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D9V81_RS00335	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D9V81_RS00340	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D9V81_RS00350	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D9V81_RS00355	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D9V81_RS00365	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D9V81_RS00370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D9V81_RS00385	COG2840	Smr protein MutS2
D9V81_RS00395	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
D9V81_RS00405	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D9V81_RS00405	COG0131	Imidazoleglycerol-phosphate dehydratase
D9V81_RS00410	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
D9V81_RS00415	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
D9V81_RS00420	COG0107	imidazoleglycerol-phosphate synthase activity
D9V81_RS00425	COG0140	phosphoribosyl-ATP diphosphatase activity
D9V81_RS00425	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D9V81_RS00430	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
D9V81_RS00440	COG0037	tRNA processing
D9V81_RS00450	COG0307	riboflavin synthase, alpha
D9V81_RS00460	COG0316	Belongs to the HesB IscA family
D9V81_RS00465	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
D9V81_RS00470	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
D9V81_RS00475	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D9V81_RS00480	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D9V81_RS00490	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D9V81_RS00495	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D9V81_RS00495	COG0072	phenylalanine-tRNA ligase activity
D9V81_RS00500	COG0751	glycine-tRNA ligase activity
D9V81_RS00505	COG0752	glycyl-tRNA synthetase alpha subunit
D9V81_RS00510	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
D9V81_RS00515	COG0586	Pfam SNARE associated Golgi protein
D9V81_RS00520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
D9V81_RS00525	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
D9V81_RS00530	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D9V81_RS00535	COG0505	Belongs to the CarA family
D9V81_RS00540	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D9V81_RS00545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D9V81_RS00550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
D9V81_RS00555	COG0268	Binds directly to 16S ribosomal RNA
D9V81_RS00560	COG0484	heat shock protein binding
D9V81_RS00570	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D9V81_RS00580	COG0649	NAD binding
D9V81_RS00580	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D9V81_RS00585	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
D9V81_RS00590	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
D9V81_RS00595	COG1034	ATP synthesis coupled electron transport
D9V81_RS00600	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
D9V81_RS00605	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D9V81_RS00610	COG0839	Belongs to the complex I subunit 6 family
D9V81_RS00620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D9V81_RS00625	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D9V81_RS00630	COG1007	ATP synthesis coupled electron transport
D9V81_RS00635	COG0285	dihydrofolate synthase activity
D9V81_RS00640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D9V81_RS00650	COG2890	protein-(glutamine-N5) methyltransferase activity
D9V81_RS00655	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
D9V81_RS00660	COG0857	belongs to the CobB CobQ family
D9V81_RS00660	COG0280	phosphate acetyltransferase
D9V81_RS00665	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D9V81_RS00670	COG3416	Protein conserved in bacteria
D9V81_RS00675	COG0450	alkyl hydroperoxide reductase
D9V81_RS00685	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
D9V81_RS00695	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
D9V81_RS00700	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D9V81_RS00705	COG0012	GTP binding
D9V81_RS00710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D9V81_RS00715	COG0083	homoserine kinase activity
D9V81_RS00720	COG0460	homoserine dehydrogenase
D9V81_RS00720	COG0527	aspartate kinase activity
D9V81_RS00725	COG0101	tRNA pseudouridine synthase activity
D9V81_RS00735	COG0516	GMP reductase activity
D9V81_RS00740	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
D9V81_RS00745	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9V81_RS00750	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
D9V81_RS00755	COG0316	Belongs to the HesB IscA family
D9V81_RS00760	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D9V81_RS00765	COG0849	cell division
D9V81_RS00770	COG0275	rRNA processing
D9V81_RS00775	COG0440	acetolactate synthase activity
D9V81_RS00780	COG0028	Belongs to the TPP enzyme family
D9V81_RS00785	COG2171	N-acyltransferase activity
D9V81_RS00790	COG0024	Methionine aminopeptidase
D9V81_RS00795	COG0052	Belongs to the universal ribosomal protein uS2 family
D9V81_RS00805	COG0528	UMP kinase activity
D9V81_RS00815	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D9V81_RS00820	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
D9V81_RS00825	COG0587	DNA-directed DNA polymerase activity
D9V81_RS00835	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9V81_RS00840	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D9V81_RS00865	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
D9V81_RS00875	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
D9V81_RS00880	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
D9V81_RS00890	COG0590	tRNA wobble adenosine to inosine editing
D9V81_RS00895	COG0736	holo-[acyl-carrier-protein] synthase activity
D9V81_RS00900	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D9V81_RS00910	COG0681	Belongs to the peptidase S26 family
D9V81_RS00920	COG0482	sulfurtransferase activity
D9V81_RS00925	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D9V81_RS00930	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D9V81_RS00935	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
D9V81_RS00940	COG2095	MarC family integral membrane protein
D9V81_RS00945	COG0321	lipoyl(octanoyl) transferase activity
D9V81_RS00950	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
D9V81_RS00955	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D9V81_RS00960	COG1607	acyl-coa hydrolase
D9V81_RS00975	COG0134	indole-3-glycerol-phosphate synthase activity
D9V81_RS00975	COG0135	phosphoribosylanthranilate isomerase activity
D9V81_RS00990	COG0820	rRNA (adenine-C2-)-methyltransferase activity
D9V81_RS00995	COG0124	histidyl-tRNA synthetase
D9V81_RS01000	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
D9V81_RS01005	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D9V81_RS01010	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D9V81_RS01015	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D9V81_RS01020	COG2706	6-phosphogluconolactonase activity
D9V81_RS01025	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
D9V81_RS01030	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D9V81_RS01035	COG0716	FMN binding
D9V81_RS01040	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D9V81_RS01045	COG0567	Dehydrogenase, E1 component
D9V81_RS01050	COG0508	dehydrogenase complex catalyzes the overall conversion of
D9V81_RS01055	COG0588	phosphoglycerate mutase activity
D9V81_RS01060	COG0205	6-phosphofructokinase activity
D9V81_RS01065	COG0149	triose-phosphate isomerase activity
D9V81_RS01070	COG0539	negative regulation of cytoplasmic translation
D9V81_RS01080	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D9V81_RS01095	COG0492	ferredoxin-NADP+ reductase activity
D9V81_RS01100	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D9V81_RS01110	COG0469	pyruvate kinase activity
D9V81_RS01115	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
D9V81_RS01120	COG0501	Belongs to the peptidase M48B family
D9V81_RS01125	COG1253	flavin adenine dinucleotide binding
D9V81_RS01130	COG1214	PFAM Peptidase M22, glycoprotease
D9V81_RS01155	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
D9V81_RS01160	COG2894	cell division
D9V81_RS01170	COG2813	Specifically methylates the guanine in position
D9V81_RS01190	COG0728	peptidoglycan biosynthetic process
D9V81_RS01195	COG0564	pseudouridine synthase activity
D9V81_RS01200	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D9V81_RS01205	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D9V81_RS01210	COG1028	Short-chain dehydrogenase reductase Sdr
D9V81_RS01215	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
D9V81_RS01220	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
D9V81_RS01225	COG0470	DNA polymerase III
D9V81_RS01230	COG0084	hydrolase, TatD family'
D9V81_RS01235	COG1263	PTS System
D9V81_RS01235	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
D9V81_RS01245	COG0017	Asparaginyl-tRNA synthetase
D9V81_RS01250	COG0525	valine-tRNA ligase activity
D9V81_RS01255	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D9V81_RS01260	COG0251	oxidation-reduction process
D9V81_RS01265	COG0513	Belongs to the DEAD box helicase family
D9V81_RS01270	COG1185	polyribonucleotide nucleotidyltransferase activity
D9V81_RS01275	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D9V81_RS01280	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
D9V81_RS01285	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
D9V81_RS01290	COG3064	Membrane
D9V81_RS01290	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
D9V81_RS01295	COG0195	Participates in both transcription termination and antitermination
D9V81_RS01310	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D9V81_RS01315	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
D9V81_RS01325	COG5007	Belongs to the BolA IbaG family
D9V81_RS01340	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
D9V81_RS01345	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D9V81_RS01355	COG1605	Chorismate mutase
D9V81_RS01355	COG0077	Prephenate dehydratase
D9V81_RS01360	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D9V81_RS01365	COG0228	four-way junction DNA binding
D9V81_RS01370	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
D9V81_RS01375	COG0336	Belongs to the RNA methyltransferase TrmD family
D9V81_RS01390	COG0564	pseudouridine synthase activity
D9V81_RS01395	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
D9V81_RS01400	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
D9V81_RS01435	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D9V81_RS01440	COG0148	phosphopyruvate hydratase activity
D9V81_RS01445	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
D9V81_RS01460	COG0354	folic acid binding
D9V81_RS01470	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
D9V81_RS01475	COG0019	diaminopimelate decarboxylase activity
D9V81_RS01480	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D9V81_RS01485	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
D9V81_RS01490	COG0495	leucyl-tRNA aminoacylation
D9V81_RS01505	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D9V81_RS01510	COG2095	MarC family integral membrane protein
D9V81_RS01515	COG0126	phosphoglycerate kinase activity
D9V81_RS01520	COG0191	fructose-bisphosphate aldolase activity
D9V81_RS01525	COG0668	transmembrane transport
D9V81_RS01535	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D9V81_RS01540	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D9V81_RS01540	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
D9V81_RS01545	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
D9V81_RS01550	COG2920	part of a sulfur-relay system
D9V81_RS01560	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
D9V81_RS01565	COG1845	cytochrome c oxidase, subunit III
D9V81_RS01570	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
D9V81_RS01575	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
D9V81_RS01580	COG0271	Belongs to the BolA IbaG family
D9V81_RS01585	COG0544	peptidyl-prolyl cis-trans isomerase activity
D9V81_RS01590	COG0740	serine-type endopeptidase activity
D9V81_RS01595	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D9V81_RS01600	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D9V81_RS01605	COG1132	(ABC) transporter
D9V81_RS01610	COG1132	(ABC) transporter
D9V81_RS01620	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D9V81_RS01625	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D9V81_RS01630	COG0326	Molecular chaperone. Has ATPase activity
D9V81_RS01645	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
D9V81_RS01650	COG0215	cysteine-tRNA ligase activity
D9V81_RS01655	COG1278	Cold shock
D9V81_RS01675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D9V81_RS01680	COG0009	L-threonylcarbamoyladenylate synthase
D9V81_RS01685	COG0242	peptide deformylase activity
D9V81_RS01695	COG0203	ribosomal protein L17
D9V81_RS01700	COG0202	RNA polymerase activity
D9V81_RS01705	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
D9V81_RS01715	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
D9V81_RS01720	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D9V81_RS01725	COG0201	protein transport
D9V81_RS01730	COG0200	Binds to the 23S rRNA
D9V81_RS01740	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D9V81_RS01750	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D9V81_RS01760	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D9V81_RS01765	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D9V81_RS01770	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D9V81_RS01780	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D9V81_RS01785	COG0255	Belongs to the universal ribosomal protein uL29 family
D9V81_RS01790	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D9V81_RS01795	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D9V81_RS01800	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
D9V81_RS01805	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D9V81_RS01810	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
D9V81_RS01815	COG0089	rRNA binding
D9V81_RS01825	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D9V81_RS01830	COG0051	transcription antitermination factor activity, RNA binding
D9V81_RS01835	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D9V81_RS01845	COG0049	tRNA binding
D9V81_RS01850	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
D9V81_RS01855	COG2168	tRNA wobble position uridine thiolation
D9V81_RS01860	COG2923	Belongs to the DsrF TusC family
D9V81_RS01875	COG0180	Tryptophanyl-tRNA synthetase
D9V81_RS01880	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D9V81_RS01885	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
D9V81_RS01910	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
D9V81_RS01910	COG0316	Belongs to the HesB IscA family
D9V81_RS01915	COG0629	single-stranded DNA binding
D9V81_RS01920	COG0305	Participates in initiation and elongation during chromosome replication
D9V81_RS01925	COG1678	Uncharacterized ACR, COG1678
D9V81_RS01935	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D9V81_RS01940	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D9V81_RS01945	COG1194	a g-specific adenine glycosylase
D9V81_RS01950	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
D9V81_RS01955	COG2925	Exonuclease
D9V81_RS01985	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D9V81_RS01990	COG0512	Glutamine amidotransferase of anthranilate synthase
D9V81_RS02000	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
D9V81_RS02005	COG0166	Belongs to the GPI family
D9V81_RS02010	COG0071	Belongs to the small heat shock protein (HSP20) family
D9V81_RS02015	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
D9V81_RS02030	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
D9V81_RS02035	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
D9V81_RS02040	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
D9V81_RS02045	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
D9V81_RS02055	COG0742	ribosomal rna small subunit methyltransferase
D9V81_RS02060	COG2814	Major facilitator Superfamily
D9V81_RS02065	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
D9V81_RS02070	COG1965	Belongs to the frataxin family
D9V81_RS02090	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D9V81_RS02095	COG3118	belongs to the thioredoxin family
D9V81_RS02100	COG0210	DNA helicase
D9V81_RS02105	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
D9V81_RS02110	COG0129	dihydroxy-acid dehydratase activity
D9V81_RS02120	COG1104	cysteine desulfurase activity
D9V81_RS02125	COG0822	iron-sulfur transferase activity
D9V81_RS02130	COG0633	Ferredoxin