locus-tag	class	description
C5S_RS01000000103180	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
C5S_RS0100015	COG0356	it plays a direct role in the translocation of protons across the membrane
C5S_RS0100025	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
C5S_RS0100055	COG0187	DNA topoisomerase II activity
C5S_RS0100060	COG0592	DNA-directed DNA polymerase activity
C5S_RS0100080	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
C5S_RS0100100	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
C5S_RS0100105	COG1484	DNA-dependent DNA replication
C5S_RS0100115	COG0742	ribosomal rna small subunit methyltransferase
C5S_RS0100120	COG0552	protein localization to endoplasmic reticulum
C5S_RS0100125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5S_RS0100130	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
C5S_RS0100140	COG0561	phosphatase activity
C5S_RS0100145	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
C5S_RS0100155	COG0776	regulation of translation
C5S_RS0100165	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
C5S_RS0100195	COG0250	Participates in transcription elongation, termination and antitermination
C5S_RS0100200	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5S_RS0100225	COG0812	UDP-N-acetylmuramate dehydrogenase activity
C5S_RS0100230	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
C5S_RS0100255	COG0165	Argininosuccinate lyase
C5S_RS0100260	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
C5S_RS0100270	COG1045	serine acetyltransferase
C5S_RS0100275	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
C5S_RS0100280	COG0358	DNA primase activity
C5S_RS0100315	COG2190	(PTS) system
C5S_RS0100320	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
C5S_RS0100325	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5S_RS0100330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
C5S_RS0100350	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
C5S_RS0100360	COG1677	Flagellar hook-basal body complex protein FliE
C5S_RS0100365	COG1766	The M ring may be actively involved in energy transduction
C5S_RS0100370	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5S_RS0100375	COG1317	bacterial-type flagellum organization
C5S_RS0100380	COG1157	protein secretion by the type III secretion system
C5S_RS0100385	COG2882	bacterial-type flagellum organization
C5S_RS0100395	COG3144	bacterial-type flagellum assembly
C5S_RS0100400	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5S_RS0100405	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
C5S_RS0100410	COG1338	Plays a role in the flagellum-specific transport system
C5S_RS0100410	COG3190	flagellar
C5S_RS0100415	COG1987	bacterial-type flagellum assembly
C5S_RS0100420	COG1684	flagellar biosynthetic protein fliR
C5S_RS0100440	COG2911	Protein conserved in bacteria
C5S_RS0100445	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
C5S_RS0100450	COG0312	modulator of DNA gyrase
C5S_RS0100455	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
C5S_RS0100460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
C5S_RS0100470	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
C5S_RS0100510	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
C5S_RS0100525	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
C5S_RS0100535	COG0107	imidazoleglycerol-phosphate synthase activity
C5S_RS0100540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
C5S_RS0100540	COG0140	phosphoribosyl-ATP diphosphatase activity
C5S_RS0100545	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
C5S_RS0100550	COG0717	Belongs to the dCTP deaminase family
C5S_RS0100560	COG0037	tRNA processing
C5S_RS0100570	COG0307	riboflavin synthase, alpha
C5S_RS0100590	COG4656	Part of a membrane complex involved in electron transport
C5S_RS0100605	COG4659	FMN binding
C5S_RS0100615	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
C5S_RS0100620	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
C5S_RS0100630	COG0316	Belongs to the HesB IscA family
C5S_RS0100635	COG0628	permease
C5S_RS0100640	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
C5S_RS0100665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
C5S_RS0100670	COG0072	phenylalanine-tRNA ligase activity
C5S_RS0100670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
C5S_RS0100690	COG1862	Preprotein translocase
C5S_RS0100715	COG0586	Pfam SNARE associated Golgi protein
C5S_RS0100720	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5S_RS0100725	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
C5S_RS0100735	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
C5S_RS0100740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C5S_RS0100745	COG0505	Belongs to the CarA family
C5S_RS0100770	COG0196	riboflavin kinase activity
C5S_RS0100795	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5S_RS0100810	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
C5S_RS0100815	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
C5S_RS0100820	COG1034	ATP synthesis coupled electron transport
C5S_RS0100830	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5S_RS0100835	COG0839	Belongs to the complex I subunit 6 family
C5S_RS0100845	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
C5S_RS0100850	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
C5S_RS0100855	COG1007	ATP synthesis coupled electron transport
C5S_RS0100860	COG0285	dihydrofolate synthase activity
C5S_RS0100875	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
C5S_RS0100880	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
C5S_RS0100890	COG2890	protein-(glutamine-N5) methyltransferase activity
C5S_RS0100895	COG2912	Transglutaminase-like superfamily
C5S_RS0100905	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
C5S_RS0100910	COG0280	phosphate acetyltransferase
C5S_RS0100910	COG0857	belongs to the CobB CobQ family
C5S_RS0100915	COG0633	Ferredoxin
C5S_RS0100920	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5S_RS0100925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
C5S_RS0100930	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
C5S_RS0100935	COG3416	Protein conserved in bacteria
C5S_RS0100940	COG0450	alkyl hydroperoxide reductase
C5S_RS0100950	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C5S_RS0100960	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5S_RS0100965	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
C5S_RS0100970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5S_RS0100975	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
C5S_RS0100985	COG0012	GTP binding
C5S_RS0100990	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
C5S_RS0101000	COG0527	aspartate kinase activity
C5S_RS0101000	COG0460	homoserine dehydrogenase
C5S_RS0101005	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
C5S_RS0101020	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
C5S_RS0101030	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
C5S_RS0101040	COG0494	nUDIX hydrolase
C5S_RS0101045	COG0237	dephospho-CoA kinase activity
C5S_RS0101055	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
C5S_RS0101060	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5S_RS0101065	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
C5S_RS0101095	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
C5S_RS0101100	COG0849	cell division
C5S_RS0101120	COG0772	Belongs to the SEDS family
C5S_RS0101135	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
C5S_RS0101140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
C5S_RS0101145	COG0768	penicillin binding
C5S_RS0101160	COG0440	acetolactate synthase activity
C5S_RS0101165	COG0028	Belongs to the TPP enzyme family
C5S_RS0101175	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
C5S_RS0101180	COG2171	N-acyltransferase activity
C5S_RS0101185	COG0024	Methionine aminopeptidase
C5S_RS0101200	COG0528	UMP kinase activity
C5S_RS0101215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
C5S_RS0101220	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5S_RS0101230	COG0587	DNA-directed DNA polymerase activity
C5S_RS0101240	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C5S_RS0101245	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
C5S_RS0101280	COG0328	RNA-DNA hybrid ribonuclease activity
C5S_RS0101285	COG0328	RNA-DNA hybrid ribonuclease activity
C5S_RS0101290	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
C5S_RS0101305	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
C5S_RS0101310	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
C5S_RS0101325	COG0590	tRNA wobble adenosine to inosine editing
C5S_RS0101345	COG0681	Belongs to the peptidase S26 family
C5S_RS0101355	COG0482	sulfurtransferase activity
C5S_RS0101365	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
C5S_RS0101370	COG0741	lytic transglycosylase activity
C5S_RS0101375	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
C5S_RS0101385	COG2095	MarC family integral membrane protein
C5S_RS0101390	COG0321	lipoyl(octanoyl) transferase activity
C5S_RS0101410	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
C5S_RS0101415	COG2916	Histone family protein nucleoid-structuring protein H-NS
C5S_RS0101425	COG1607	acyl-coa hydrolase
C5S_RS0101445	COG0133	tryptophan synthase activity
C5S_RS0101450	COG0135	phosphoribosylanthranilate isomerase activity
C5S_RS0101450	COG0134	indole-3-glycerol-phosphate synthase activity
C5S_RS0101460	COG0697	spore germination
C5S_RS0101465	COG1187	pseudouridine synthase activity
C5S_RS0101470	COG0616	signal peptide processing
C5S_RS0101475	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
C5S_RS0101475	COG0551	DNA topoisomerase type I activity
C5S_RS0101480	COG0483	inositol monophosphate 1-phosphatase activity
C5S_RS0101485	COG0820	rRNA (adenine-C2-)-methyltransferase activity
C5S_RS0101490	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
C5S_RS0101495	COG0124	histidyl-tRNA synthetase
C5S_RS0101515	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
C5S_RS0101525	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
C5S_RS0101530	COG4591	ABC-type transport system involved in lipoprotein release permease component
C5S_RS0101535	COG1136	(ABC) transporter
C5S_RS0101545	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
C5S_RS0101550	COG0716	FMN binding
C5S_RS0101555	COG0415	Belongs to the DNA photolyase family
C5S_RS0101560	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
C5S_RS0101565	COG0567	Dehydrogenase, E1 component
C5S_RS0101570	COG0508	dehydrogenase complex catalyzes the overall conversion of
C5S_RS0101585	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
C5S_RS0101590	COG0149	triose-phosphate isomerase activity
C5S_RS0101600	COG0539	negative regulation of cytoplasmic translation
C5S_RS0101605	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C5S_RS0101610	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
C5S_RS0101630	COG0492	ferredoxin-NADP+ reductase activity
C5S_RS0101635	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
C5S_RS0101645	COG1108	ABC-type Mn2 Zn2 transport systems permease components
C5S_RS0101650	COG1121	(ABC) transporter
C5S_RS0101655	COG0469	pyruvate kinase activity
C5S_RS0101660	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
C5S_RS0101670	COG1278	Cold shock
C5S_RS0101680	COG1253	flavin adenine dinucleotide binding
C5S_RS0101685	COG1214	PFAM Peptidase M22, glycoprotease
C5S_RS0101695	COG2894	cell division
C5S_RS0101710	COG2813	Specifically methylates the guanine in position
C5S_RS0101725	COG2885	chlorophyll binding
C5S_RS0101725	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
C5S_RS0101730	COG0728	peptidoglycan biosynthetic process
C5S_RS0101740	COG3418	PFAM FlgN family protein
C5S_RS0101745	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
C5S_RS0101755	COG1815	bacterial-type flagellum-dependent cell motility
C5S_RS0101760	COG1558	bacterial-type flagellum-dependent cell motility
C5S_RS0101765	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
C5S_RS0101770	COG1749	Flagellar hook protein flgE
C5S_RS0101775	COG4787	bacterial-type flagellum-dependent cell motility
C5S_RS0101780	COG4786	Flagellar basal body rod
C5S_RS0101790	COG1706	bacterial-type flagellum-dependent cell motility
C5S_RS0101795	COG3951	Flagellar rod assembly protein muramidase FlgJ
C5S_RS0101800	COG1256	bacterial-type flagellum assembly
C5S_RS0101805	COG1530	ribonuclease E activity
C5S_RS0101810	COG0564	pseudouridine synthase activity
C5S_RS0101810	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
C5S_RS0101820	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C5S_RS0101825	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
C5S_RS0101830	COG1028	Short-chain dehydrogenase reductase Sdr
C5S_RS0101840	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
C5S_RS0101845	COG0470	DNA polymerase III
C5S_RS0101850	COG0084	hydrolase, TatD family'
C5S_RS0101855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
C5S_RS0101855	COG1263	PTS System
C5S_RS0101860	COG0537	adenosine 5'-monophosphoramidase activity
C5S_RS0101865	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
C5S_RS0101870	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
C5S_RS0101875	COG0017	Asparaginyl-tRNA synthetase
C5S_RS0101885	COG0167	dihydroorotate dehydrogenase activity
C5S_RS0101890	COG0167	dihydroorotate dehydrogenase activity
C5S_RS0101895	COG0116	Belongs to the methyltransferase superfamily
C5S_RS0101895	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
C5S_RS0101900	COG0488	(ABC) transporter
C5S_RS0101910	COG0525	valine-tRNA ligase activity
C5S_RS0101940	COG0251	oxidation-reduction process
C5S_RS0101945	COG0513	Belongs to the DEAD box helicase family
C5S_RS0101960	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
C5S_RS0101975	COG0195	Participates in both transcription termination and antitermination
C5S_RS0101985	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
C5S_RS0101995	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
C5S_RS0102010	COG5007	Belongs to the BolA IbaG family
C5S_RS0102045	COG0077	Prephenate dehydratase
C5S_RS0102045	COG1605	Chorismate mutase
C5S_RS0102050	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
C5S_RS0102060	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
C5S_RS0102065	COG0336	Belongs to the RNA methyltransferase TrmD family
C5S_RS0102075	COG0312	modulator of DNA gyrase
C5S_RS0102095	COG0564	pseudouridine synthase activity
C5S_RS0102100	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
C5S_RS0102105	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
C5S_RS0102135	COG2356	endonuclease I
C5S_RS0102140	COG1385	rRNA (uridine-N3-)-methyltransferase activity
C5S_RS0102180	COG1388	LysM domain
C5S_RS0102180	COG0739	heme binding
C5S_RS0102190	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
C5S_RS0102195	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
C5S_RS0102200	COG0529	Catalyzes the synthesis of activated sulfate
C5S_RS0102215	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
C5S_RS0102215	COG1648	precorrin-2 dehydrogenase activity
C5S_RS0102230	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
C5S_RS0102240	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
C5S_RS0102245	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
C5S_RS0102255	COG1217	gtp-binding protein TYPA
C5S_RS0102260	COG0194	GDP metabolic process
C5S_RS0102265	COG0354	folic acid binding
C5S_RS0102270	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
C5S_RS0102275	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
C5S_RS0102280	COG0019	diaminopimelate decarboxylase activity
C5S_RS0102295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
C5S_RS0102305	COG4535	Mg2 and Co2 transporter CorC
C5S_RS0102310	COG0495	leucyl-tRNA aminoacylation
C5S_RS0102315	COG1466	dna polymerase III delta subunit
C5S_RS0102330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
C5S_RS0102335	COG2095	MarC family integral membrane protein
C5S_RS0102345	COG0191	fructose-bisphosphate aldolase activity
C5S_RS0102350	COG0668	transmembrane transport
C5S_RS0102360	COG1074	ATP-dependent DNA helicase activity
C5S_RS0102365	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
C5S_RS0102370	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
C5S_RS0102370	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
C5S_RS0102380	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
C5S_RS0102390	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
C5S_RS0102395	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5S_RS0102400	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
C5S_RS0102415	COG0142	geranyltranstransferase activity
C5S_RS0102420	COG2814	Major facilitator Superfamily
C5S_RS0102425	COG2920	part of a sulfur-relay system
C5S_RS0102435	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
C5S_RS0102440	COG1845	cytochrome c oxidase, subunit III
C5S_RS0102445	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
C5S_RS0102450	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
C5S_RS0102455	COG0271	Belongs to the BolA IbaG family
C5S_RS0102465	COG0740	serine-type endopeptidase activity
C5S_RS0102475	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
C5S_RS0102480	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
C5S_RS0102490	COG1132	(ABC) transporter
C5S_RS0102495	COG1132	(ABC) transporter
C5S_RS0102500	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
C5S_RS0102510	COG0326	Molecular chaperone. Has ATPase activity
C5S_RS0102525	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
C5S_RS0102540	COG1278	Cold shock
C5S_RS0102575	COG0009	L-threonylcarbamoyladenylate synthase
C5S_RS0102600	COG0202	RNA polymerase activity
C5S_RS0102625	COG0201	protein transport
C5S_RS0102640	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
C5S_RS0102650	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
C5S_RS0102660	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
C5S_RS0102770	COG0545	Peptidyl-prolyl cis-trans isomerase
C5S_RS0102775	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
C5S_RS0102785	COG0180	Tryptophanyl-tRNA synthetase
C5S_RS0102790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
C5S_RS0102795	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
C5S_RS0102800	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
C5S_RS0102830	COG0629	single-stranded DNA binding
C5S_RS0102835	COG0305	Participates in initiation and elongation during chromosome replication
C5S_RS0102840	COG0189	ligase activity
C5S_RS0102850	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
C5S_RS0102855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
C5S_RS0102865	COG1194	a g-specific adenine glycosylase
C5S_RS0102870	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
C5S_RS0102880	COG2925	Exonuclease
C5S_RS0102910	COG1218	3'(2'),5'-bisphosphate nucleotidase
C5S_RS0102930	COG0557	exoribonuclease II activity
C5S_RS0102940	COG0330	HflC and HflK could
C5S_RS0102945	COG0330	HflC and HflK could
C5S_RS0102965	COG2213	PTS system mannitol-specific
C5S_RS0102965	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
C5S_RS0102980	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
C5S_RS0102995	COG0860	N-Acetylmuramoyl-L-alanine amidase
C5S_RS0103015	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
C5S_RS0103025	COG0071	Belongs to the small heat shock protein (HSP20) family
C5S_RS0103030	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
C5S_RS0103060	COG0306	phosphate transporter
C5S_RS0103065	COG2814	Major facilitator Superfamily
C5S_RS0103110	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
C5S_RS0103115	COG3118	belongs to the thioredoxin family
C5S_RS0103120	COG0210	DNA helicase
C5S_RS0103145	COG0822	iron-sulfur transferase activity
C5S_RS0103160	COG0633	Ferredoxin
C5S_RS0103170	COG2976	Protein conserved in bacteria
C5S_RS1000000103250	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA