locus-tag	class	description
JOS54_RS00010	COG0592	DNA-directed DNA polymerase activity
JOS54_RS00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JOS54_RS00025	COG0187	DNA topoisomerase II activity
JOS54_RS00035	COG0071	Belongs to the small heat shock protein (HSP20) family
JOS54_RS00040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JOS54_RS00050	COG0590	tRNA wobble adenosine to inosine editing
JOS54_RS00055	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JOS54_RS00060	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JOS54_RS00065	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JOS54_RS00075	COG0445	tRNA wobble uridine modification
JOS54_RS00090	COG1475	DNA binding
JOS54_RS00095	COG1192	Involved in chromosome partitioning
JOS54_RS00100	COG1475	DNA binding
JOS54_RS00110	COG0356	it plays a direct role in the translocation of protons across the membrane
JOS54_RS00120	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JOS54_RS00130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JOS54_RS00135	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JOS54_RS00140	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JOS54_RS00145	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JOS54_RS00155	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JOS54_RS00160	COG0084	hydrolase, TatD family'
JOS54_RS00165	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JOS54_RS00170	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JOS54_RS00175	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JOS54_RS00185	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JOS54_RS00190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JOS54_RS00195	COG1278	Cold shock
JOS54_RS00200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JOS54_RS00200	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JOS54_RS00205	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JOS54_RS00210	COG2190	(PTS) system
JOS54_RS00210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JOS54_RS00210	COG1263	PTS System
JOS54_RS00215	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JOS54_RS00220	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JOS54_RS00225	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
JOS54_RS00230	COG0546	phosphoglycolate phosphatase activity
JOS54_RS00240	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JOS54_RS00245	COG1481	regulation of sporulation
JOS54_RS00275	COG0215	cysteine-tRNA ligase activity
JOS54_RS00280	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
JOS54_RS00285	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JOS54_RS00295	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JOS54_RS00305	COG0250	Participates in transcription elongation, termination and antitermination
JOS54_RS00325	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JOS54_RS00330	COG0081	regulation of translation
JOS54_RS00350	COG2813	Specifically methylates the guanine in position
JOS54_RS00370	COG1131	(ABC) transporter
JOS54_RS00380	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JOS54_RS00405	COG0802	atpase or kinase
JOS54_RS00410	COG1214	PFAM Peptidase M22, glycoprotease
JOS54_RS00415	COG0456	acetyltransferase
JOS54_RS00420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JOS54_RS00435	COG0488	(ABC) transporter
JOS54_RS00440	COG0205	6-phosphofructokinase activity
JOS54_RS00450	COG3177	Filamentation induced by cAMP protein fic
JOS54_RS00505	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JOS54_RS00505	COG1263	PTS System
JOS54_RS00505	COG2190	(PTS) system
JOS54_RS00510	COG2723	6-phospho-beta-galactosidase activity
JOS54_RS00530	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JOS54_RS00550	COG1461	Dihydroxyacetone kinase
JOS54_RS00560	COG0475	glutathione-regulated potassium exporter activity
JOS54_RS00580	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
JOS54_RS00585	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JOS54_RS00590	COG0739	heme binding
JOS54_RS00600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JOS54_RS00605	COG2884	Cell division ATP-binding protein ftsE
JOS54_RS00610	COG2177	Part of the ABC transporter FtsEX involved in
JOS54_RS00615	COG0793	Belongs to the peptidase S41A family
JOS54_RS00620	COG0556	nucleotide-excision repair
JOS54_RS00625	COG0360	Binds together with S18 to 16S ribosomal RNA
JOS54_RS00630	COG0629	single-stranded DNA binding
JOS54_RS00635	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JOS54_RS00640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JOS54_RS00645	COG0803	Belongs to the bacterial solute-binding protein 9 family
JOS54_RS00650	COG1121	(ABC) transporter
JOS54_RS00655	COG1321	iron dependent repressor
JOS54_RS00655	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JOS54_RS00660	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JOS54_RS00670	COG0745	RESPONSE REGULATOR receiver
JOS54_RS00675	COG5002	protein histidine kinase activity
JOS54_RS00685	COG1136	(ABC) transporter
JOS54_RS00690	COG2252	PERMEase
JOS54_RS00695	COG0588	phosphoglycerate mutase activity
JOS54_RS00720	COG1122	ATPase activity
JOS54_RS00725	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
JOS54_RS00730	COG0101	tRNA pseudouridine synthase activity
JOS54_RS00740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JOS54_RS00745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JOS54_RS00750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JOS54_RS00750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JOS54_RS00750	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JOS54_RS00755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JOS54_RS00755	COG3711	transcriptional antiterminator
JOS54_RS00760	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JOS54_RS00765	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JOS54_RS00780	COG0446	pyridine nucleotide-disulphide oxidoreductase
JOS54_RS00795	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
JOS54_RS00800	COG0359	binds to the 23S rRNA
JOS54_RS00805	COG0305	Participates in initiation and elongation during chromosome replication
JOS54_RS00825	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JOS54_RS00830	COG1528	Iron-storage protein
JOS54_RS00840	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JOS54_RS00850	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JOS54_RS00855	COG0126	phosphoglycerate kinase activity
JOS54_RS00860	COG0149	triose-phosphate isomerase activity
JOS54_RS00875	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JOS54_RS00880	COG0557	exoribonuclease II activity
JOS54_RS00885	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
JOS54_RS00915	COG0698	ribose 5-phosphate isomerase
JOS54_RS00920	COG1053	succinate dehydrogenase
JOS54_RS00930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JOS54_RS00940	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JOS54_RS00945	COG1028	Short-chain dehydrogenase reductase Sdr
JOS54_RS00950	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
JOS54_RS00955	COG2843	Capsule synthesis protein
JOS54_RS00970	COG1192	Involved in chromosome partitioning
JOS54_RS01175	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
JOS54_RS01175	COG0517	IMP dehydrogenase activity
JOS54_RS01190	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JOS54_RS01195	COG2313	pseudouridylate synthase activity
JOS54_RS01200	COG2746	aminoglycoside 3-N-acetyltransferase activity
JOS54_RS01205	COG1956	GAF domain-containing protein
JOS54_RS01210	COG3557	Belongs to the UPF0374 family
JOS54_RS01230	COG1876	peptidase activity
JOS54_RS01245	COG1132	(ABC) transporter
JOS54_RS01250	COG1132	(ABC) transporter
JOS54_RS01255	COG2217	Heavy metal translocating P-type atpase
JOS54_RS01260	COG1950	PFAM Membrane protein of
JOS54_RS01275	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JOS54_RS01280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JOS54_RS01295	COG4821	SIS domain
JOS54_RS01315	COG1490	D-aminoacyl-tRNA deacylase activity
JOS54_RS01325	COG4481	Protein conserved in bacteria
JOS54_RS01330	COG0012	GTP binding
JOS54_RS01335	COG3870	Protein conserved in bacteria
JOS54_RS01340	COG0617	tRNA 3'-terminal CCA addition
JOS54_RS01345	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
JOS54_RS01350	COG1078	dGTPase activity
JOS54_RS01370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JOS54_RS01375	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JOS54_RS01380	COG0254	rRNA binding
JOS54_RS01385	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JOS54_RS01395	COG1368	sulfuric ester hydrolase activity
JOS54_RS01400	COG4509	Sortase family
JOS54_RS01405	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JOS54_RS01415	COG0009	L-threonylcarbamoyladenylate synthase
JOS54_RS01425	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JOS54_RS01440	COG0037	tRNA processing
JOS54_RS01445	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
JOS54_RS01450	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
JOS54_RS01465	COG3250	beta-galactosidase activity
JOS54_RS01470	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JOS54_RS01475	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JOS54_RS01480	COG3022	response to hydroperoxide
JOS54_RS01485	COG3022	response to hydroperoxide
JOS54_RS01505	COG1937	Protein conserved in bacteria
JOS54_RS01510	COG2217	Heavy metal translocating P-type atpase
JOS54_RS01520	COG0656	L-ascorbic acid biosynthetic process
JOS54_RS01540	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
JOS54_RS01550	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JOS54_RS01565	COG0493	'glutamate synthase
JOS54_RS01645	COG1811	Na channel or pump
JOS54_RS01650	COG2843	Capsule synthesis protein
JOS54_RS01670	COG1121	(ABC) transporter
JOS54_RS01690	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
JOS54_RS01695	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JOS54_RS01695	COG1328	CTP reductase activity
JOS54_RS01710	COG0517	IMP dehydrogenase activity
JOS54_RS01710	COG1227	inorganic diphosphatase activity
JOS54_RS01735	COG1309	transcriptional regulator
JOS54_RS01740	COG1132	(ABC) transporter
JOS54_RS01745	COG1132	(ABC) transporter
JOS54_RS01750	COG1129	ABC transporter
JOS54_RS01830	COG0018	arginyl-trna synthetase
JOS54_RS01835	COG2235	arginine
JOS54_RS01840	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
JOS54_RS01845	COG0549	Belongs to the carbamate kinase family
JOS54_RS01850	COG1288	antiporter activity
JOS54_RS01855	COG1917	Cupin 2, conserved barrel domain protein
JOS54_RS01855	COG4977	sequence-specific DNA binding
JOS54_RS01865	COG0772	Belongs to the SEDS family
JOS54_RS01870	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JOS54_RS01905	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JOS54_RS01910	COG1362	aminopeptidase activity
JOS54_RS01925	COG1053	succinate dehydrogenase
JOS54_RS01930	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JOS54_RS01935	COG3250	beta-galactosidase activity
JOS54_RS01945	COG1312	Catalyzes the dehydration of D-mannonate
JOS54_RS01950	COG0246	Mannitol dehydrogenase
JOS54_RS01980	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JOS54_RS01985	COG0187	DNA topoisomerase II activity
JOS54_RS01990	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
JOS54_RS01995	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JOS54_RS02015	COG3935	DnaD domain protein
JOS54_RS02020	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JOS54_RS02025	COG1307	EDD domain protein, DegV family
JOS54_RS02040	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JOS54_RS02040	COG4499	WXG100 protein secretion system (Wss), protein YukC
JOS54_RS02045	COG3331	DNA recombination
JOS54_RS02050	COG3599	regulation of cell shape
JOS54_RS02060	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JOS54_RS02070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JOS54_RS02080	COG1418	mRNA catabolic process
JOS54_RS02085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
JOS54_RS02095	COG1674	ftsk spoiiie
JOS54_RS02110	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JOS54_RS02115	COG0228	four-way junction DNA binding
JOS54_RS02125	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JOS54_RS02130	COG0336	Belongs to the RNA methyltransferase TrmD family
JOS54_RS02155	COG2045	Belongs to the ComB family
JOS54_RS02165	COG0335	large ribosomal subunit rRNA binding
JOS54_RS02180	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JOS54_RS02185	COG0758	DNA mediated transformation
JOS54_RS02190	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JOS54_RS02195	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
JOS54_RS02225	COG0052	Belongs to the universal ribosomal protein uS2 family
JOS54_RS02230	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JOS54_RS02240	COG0528	UMP kinase activity
JOS54_RS02255	COG4589	Belongs to the CDS family
JOS54_RS02265	COG0750	zinc metalloprotease
JOS54_RS02280	COG2267	carboxylic ester hydrolase activity
JOS54_RS02290	COG0628	permease
JOS54_RS02300	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JOS54_RS02300	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JOS54_RS02305	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JOS54_RS02310	COG0237	dephospho-CoA kinase activity
JOS54_RS02325	COG0205	6-phosphofructokinase activity
JOS54_RS02340	COG2364	Membrane
JOS54_RS02385	COG3457	Alanine racemase
JOS54_RS02395	COG3064	Membrane
JOS54_RS02395	COG3525	Glycosyl hydrolase, family 20, catalytic domain
JOS54_RS02395	COG3583	domain protein
JOS54_RS02415	COG0789	Transcriptional regulator
JOS54_RS02420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JOS54_RS02430	COG3845	ABC transporter
JOS54_RS02435	COG4603	Belongs to the binding-protein-dependent transport system permease family
JOS54_RS02440	COG1079	Belongs to the binding-protein-dependent transport system permease family
JOS54_RS02460	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
JOS54_RS02505	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
JOS54_RS02510	COG0058	SHG alpha-glucan phosphorylase activity
JOS54_RS02515	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JOS54_RS02520	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
JOS54_RS02525	COG0297	glycogen (starch) synthase activity
JOS54_RS02535	COG0584	glycerophosphoryl diester phosphodiesterase
JOS54_RS02555	COG1918	ferrous iron import across plasma membrane
JOS54_RS02555	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
JOS54_RS02560	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
JOS54_RS02570	COG0772	Belongs to the SEDS family
JOS54_RS02575	COG0742	ribosomal rna small subunit methyltransferase
JOS54_RS02580	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JOS54_RS02600	COG4555	ABC transporter
JOS54_RS02665	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JOS54_RS02740	COG1132	(ABC) transporter
JOS54_RS02740	COG2375	cellular response to nickel ion
JOS54_RS02745	COG1132	(ABC) transporter
JOS54_RS02755	COG1242	4 iron, 4 sulfur cluster binding
JOS54_RS02765	COG3588	fructose-bisphosphate aldolase
JOS54_RS02770	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JOS54_RS02785	COG1131	(ABC) transporter
JOS54_RS02790	COG2339	peptidase activity
JOS54_RS02795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JOS54_RS02810	COG3475	LICD family
JOS54_RS02815	COG3475	LICD family
JOS54_RS02840	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
JOS54_RS02855	COG1316	TRANSCRIPTIONal
JOS54_RS02870	COG1979	alcohol dehydrogenase
JOS54_RS02875	COG1435	thymidine kinase activity
JOS54_RS02880	COG0534	Mate efflux family protein
JOS54_RS02890	COG1164	Oligoendopeptidase f
JOS54_RS02895	COG0628	permease
JOS54_RS02910	COG1187	pseudouridine synthase activity
JOS54_RS02915	COG1293	RNA-binding protein homologous to eukaryotic snRNP
JOS54_RS02920	COG0577	efflux transmembrane transporter activity
JOS54_RS02920	COG1136	(ABC) transporter
JOS54_RS02925	COG0194	GDP metabolic process
JOS54_RS02930	COG3681	Belongs to the UPF0597 family
JOS54_RS02940	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
JOS54_RS02945	COG1104	cysteine desulfurase activity
JOS54_RS02950	COG0301	tRNA thio-modification
JOS54_RS02960	COG0492	ferredoxin-NADP+ reductase activity
JOS54_RS02965	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JOS54_RS02970	COG2868	ribosomal protein
JOS54_RS02980	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JOS54_RS02985	COG0632	four-way junction helicase activity
JOS54_RS02990	COG2255	four-way junction helicase activity
JOS54_RS03005	COG1132	(ABC) transporter
JOS54_RS03010	COG0525	valine-tRNA ligase activity
JOS54_RS03015	COG0574	Belongs to the PEP-utilizing enzyme family
JOS54_RS03015	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JOS54_RS03020	COG0268	Binds directly to 16S ribosomal RNA
JOS54_RS03025	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JOS54_RS03030	COG0481	GTPase activity
JOS54_RS03035	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JOS54_RS03040	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JOS54_RS03045	COG1136	(ABC) transporter
JOS54_RS03065	COG1185	polyribonucleotide nucleotidyltransferase activity
JOS54_RS03070	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JOS54_RS03095	COG1609	Transcriptional regulator
JOS54_RS03100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
JOS54_RS03110	COG0779	Required for maturation of 30S ribosomal subunits
JOS54_RS03115	COG0195	Participates in both transcription termination and antitermination
JOS54_RS03120	COG2740	Nucleic-acid-binding protein implicated in transcription termination
JOS54_RS03125	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
JOS54_RS03130	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JOS54_RS03175	COG0196	riboflavin kinase activity
JOS54_RS03180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JOS54_RS03180	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
JOS54_RS03195	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JOS54_RS03205	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JOS54_RS03230	COG1428	Deoxynucleoside kinase
JOS54_RS03245	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
JOS54_RS03270	COG0180	Tryptophanyl-tRNA synthetase
JOS54_RS03275	COG1393	Belongs to the ArsC family
JOS54_RS03280	COG0482	sulfurtransferase activity
JOS54_RS03285	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JOS54_RS03290	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JOS54_RS03295	COG4472	Bacterial protein of unknown function (DUF965)
JOS54_RS03300	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JOS54_RS03310	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JOS54_RS03315	COG1051	belongs to the nudix hydrolase family
JOS54_RS03320	COG0572	uridine kinase
JOS54_RS03345	COG1760	l-serine dehydratase
JOS54_RS03350	COG0826	peptidase U32
JOS54_RS03395	COG1196	nuclear chromosome segregation
JOS54_RS03400	COG0552	protein localization to endoplasmic reticulum
JOS54_RS03405	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
JOS54_RS03410	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JOS54_RS03415	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JOS54_RS03420	COG1131	(ABC) transporter
JOS54_RS03430	COG0513	Belongs to the DEAD box helicase family
JOS54_RS03470	COG1307	EDD domain protein, DegV family
JOS54_RS03500	COG4974	Belongs to the 'phage' integrase family
JOS54_RS03510	COG0497	DNA recombination
JOS54_RS03515	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JOS54_RS03530	COG1570	exodeoxyribonuclease VII activity
JOS54_RS03535	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JOS54_RS03540	COG0517	IMP dehydrogenase activity
JOS54_RS03540	COG0516	GMP reductase activity
JOS54_RS03545	COG0442	prolyl-tRNA aminoacylation
JOS54_RS03555	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JOS54_RS03560	COG2176	DNA-directed DNA polymerase activity
JOS54_RS03565	COG0433	COG0433 Predicted ATPase
JOS54_RS03575	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JOS54_RS03580	COG1461	Dihydroxyacetone kinase
JOS54_RS03595	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JOS54_RS03600	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
JOS54_RS03610	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JOS54_RS03615	COG0544	peptidyl-prolyl cis-trans isomerase activity
JOS54_RS03650	COG0322	excinuclease ABC activity
JOS54_RS03655	COG1193	negative regulation of DNA recombination
JOS54_RS03675	COG0564	pseudouridine synthase activity
JOS54_RS03680	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JOS54_RS03695	COG1131	(ABC) transporter
JOS54_RS03700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JOS54_RS03710	COG0745	RESPONSE REGULATOR receiver
JOS54_RS03725	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JOS54_RS03730	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JOS54_RS03735	COG0495	leucyl-tRNA aminoacylation
JOS54_RS03755	COG0235	Class ii aldolase
JOS54_RS03770	COG3037	sugar-specific permease SgaT UlaA
JOS54_RS03785	COG1349	DNA-binding transcription factor activity
JOS54_RS03790	COG1132	(ABC) transporter
JOS54_RS03795	COG2375	cellular response to nickel ion
JOS54_RS03795	COG1132	(ABC) transporter
JOS54_RS03805	COG1129	ABC transporter
JOS54_RS03840	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JOS54_RS03845	COG0587	DNA-directed DNA polymerase activity
JOS54_RS03850	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JOS54_RS03860	COG1160	GTP binding
JOS54_RS03865	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JOS54_RS03875	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
JOS54_RS03880	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JOS54_RS03900	COG4537	Required for transformation and DNA binding
JOS54_RS03910	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JOS54_RS03915	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
JOS54_RS03920	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JOS54_RS03925	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
JOS54_RS03930	COG0513	Belongs to the DEAD box helicase family
JOS54_RS03935	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
JOS54_RS03940	COG1187	pseudouridine synthase activity
JOS54_RS03960	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JOS54_RS03965	COG0358	DNA primase activity
JOS54_RS03970	COG0423	glycine-tRNA ligase activity
JOS54_RS03980	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JOS54_RS03985	COG0295	cytidine deaminase activity
JOS54_RS03990	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JOS54_RS04000	COG1702	phosphate starvation-inducible protein PhoH
JOS54_RS04030	COG1192	Involved in chromosome partitioning
JOS54_RS04140	COG0629	single-stranded DNA binding
JOS54_RS04225	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JOS54_RS04230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JOS54_RS04235	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JOS54_RS04240	COG1253	flavin adenine dinucleotide binding
JOS54_RS04245	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
JOS54_RS04255	COG0534	Mate efflux family protein
JOS54_RS04265	COG1564	THIamine pyrophosphokinase
JOS54_RS04270	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JOS54_RS04275	COG1162	GTPase activity
JOS54_RS04285	COG0631	protein serine/threonine phosphatase activity
JOS54_RS04290	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JOS54_RS04295	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JOS54_RS04295	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
JOS54_RS04300	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JOS54_RS04305	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JOS54_RS04310	COG0719	Fe-S assembly protein
JOS54_RS04320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JOS54_RS04325	COG0719	Fe-S assembly protein
JOS54_RS04330	COG0396	ATPase activity
JOS54_RS04345	COG0537	adenosine 5'-monophosphoramidase activity
JOS54_RS04360	COG0789	Transcriptional regulator
JOS54_RS04410	COG3177	Filamentation induced by cAMP protein fic
JOS54_RS04420	COG2189	Belongs to the N(4) N(6)-methyltransferase family
JOS54_RS04435	COG1609	Transcriptional regulator
JOS54_RS04445	COG3716	PTS system mannose fructose sorbose family IID component
JOS54_RS04450	COG3715	PTS system
JOS54_RS04455	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JOS54_RS04460	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
JOS54_RS04465	COG0800	Aldolase
JOS54_RS04475	COG1028	Short-chain dehydrogenase reductase Sdr
JOS54_RS04500	COG0438	transferase activity, transferring glycosyl groups
JOS54_RS04515	COG1394	ATPase activity, coupled to movement of substances
JOS54_RS04520	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
JOS54_RS04525	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
JOS54_RS04545	COG1269	ATP hydrolysis coupled proton transport
JOS54_RS04560	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
JOS54_RS04560	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
JOS54_RS04560	COG0674	pyruvate-flavodoxin oxidoreductase activity
JOS54_RS04560	COG1013	pyruvate-flavodoxin oxidoreductase activity
JOS54_RS04565	COG3976	FMN-binding domain protein
JOS54_RS04565	COG1053	succinate dehydrogenase
JOS54_RS04565	COG0431	NADPH-dependent FMN reductase
JOS54_RS04570	COG3763	UPF0154 protein
JOS54_RS04585	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JOS54_RS04590	COG1725	Transcriptional regulator
JOS54_RS04595	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JOS54_RS04600	COG0124	histidyl-tRNA synthetase
JOS54_RS04605	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JOS54_RS04610	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JOS54_RS04615	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JOS54_RS04615	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
JOS54_RS04625	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JOS54_RS04635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JOS54_RS04635	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
JOS54_RS04645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JOS54_RS04650	COG0768	penicillin binding
JOS54_RS04660	COG0275	rRNA processing
JOS54_RS04665	COG2001	Belongs to the MraZ family
JOS54_RS04680	COG1323	Belongs to the UPF0348 family
JOS54_RS04690	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
JOS54_RS04695	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JOS54_RS04715	COG3579	cysteine-type endopeptidase activity
JOS54_RS04720	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
JOS54_RS04725	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JOS54_RS04740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JOS54_RS04785	COG2190	(PTS) system
JOS54_RS04785	COG1263	PTS System
JOS54_RS04785	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JOS54_RS04790	COG3711	transcriptional antiterminator
JOS54_RS04795	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JOS54_RS04795	COG1263	PTS System
JOS54_RS04795	COG2190	(PTS) system
JOS54_RS04805	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JOS54_RS04810	COG1177	transmembrane transport
JOS54_RS04815	COG1176	ABC-type spermidine putrescine transport system, permease component I
JOS54_RS04825	COG1476	TRANSCRIPTIONal
JOS54_RS04835	COG0363	glucosamine-6-phosphate deaminase activity
JOS54_RS04845	COG0280	phosphate acetyltransferase
JOS54_RS04860	COG2801	Transposase and inactivated derivatives
JOS54_RS04865	COG0459	protein refolding
JOS54_RS04870	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JOS54_RS04875	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JOS54_RS04875	COG0072	phenylalanine-tRNA ligase activity
JOS54_RS04880	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JOS54_RS04890	COG1254	Belongs to the acylphosphatase family
JOS54_RS04900	COG1012	belongs to the aldehyde dehydrogenase family
JOS54_RS04900	COG1454	alcohol dehydrogenase
JOS54_RS04905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JOS54_RS04915	COG0826	peptidase U32
JOS54_RS04945	COG2176	DNA-directed DNA polymerase activity
JOS54_RS04950	COG0640	Transcriptional regulator
JOS54_RS04960	COG0343	queuine tRNA-ribosyltransferase activity
JOS54_RS04965	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JOS54_RS04970	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JOS54_RS04990	COG1234	tRNA 3'-trailer cleavage
JOS54_RS05000	COG0024	Methionine aminopeptidase
JOS54_RS05005	COG0756	dUTP diphosphatase activity
JOS54_RS05015	COG1181	Belongs to the D-alanine--D-alanine ligase family
JOS54_RS05020	COG0813	purine-nucleoside phosphorylase activity
JOS54_RS05030	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JOS54_RS05060	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JOS54_RS05065	COG1250	3-hydroxyacyl-CoA dehydrogenase
JOS54_RS05065	COG1024	Enoyl-CoA hydratase
JOS54_RS05075	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JOS54_RS05080	COG0622	Phosphoesterase
JOS54_RS05100	COG1957	nucleoside hydrolase
JOS54_RS05110	COG1079	Belongs to the binding-protein-dependent transport system permease family
JOS54_RS05115	COG4603	Belongs to the binding-protein-dependent transport system permease family
JOS54_RS05120	COG3845	ABC transporter
JOS54_RS05125	COG1744	ABC transporter substrate-binding protein PnrA-like
JOS54_RS05130	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
JOS54_RS05135	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
JOS54_RS05140	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JOS54_RS05145	COG0039	L-malate dehydrogenase activity
JOS54_RS05150	COG0037	tRNA processing
JOS54_RS05155	COG1283	sodium-dependent phosphate transmembrane transporter activity
JOS54_RS05170	COG1194	a g-specific adenine glycosylase
JOS54_RS05175	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
JOS54_RS05195	COG4565	transcriptional regulatory protein
JOS54_RS05200	COG2972	Histidine kinase
JOS54_RS05205	COG1053	succinate dehydrogenase
JOS54_RS05205	COG3976	FMN-binding domain protein
JOS54_RS05210	COG1263	PTS System
JOS54_RS05210	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JOS54_RS05215	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JOS54_RS05220	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JOS54_RS05220	COG3711	transcriptional antiterminator
JOS54_RS05230	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JOS54_RS05235	COG0561	phosphatase activity
JOS54_RS05240	COG1454	alcohol dehydrogenase
JOS54_RS05255	COG2971	BadF BadG BcrA BcrD
JOS54_RS05265	COG3842	ATPase activity
JOS54_RS05270	COG0395	ABC-type sugar transport system, permease component
JOS54_RS05285	COG1486	melibiose metabolic process
JOS54_RS05290	COG1609	Transcriptional regulator
JOS54_RS05305	COG2239	Acts as a magnesium transporter
JOS54_RS05320	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
JOS54_RS05325	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
JOS54_RS05330	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JOS54_RS05335	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JOS54_RS05340	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JOS54_RS05345	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JOS54_RS05350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
JOS54_RS05380	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JOS54_RS05385	COG1121	(ABC) transporter
JOS54_RS05390	COG0803	Belongs to the bacterial solute-binding protein 9 family
JOS54_RS05415	COG1215	transferase activity, transferring glycosyl groups
JOS54_RS05435	COG0431	NADPH-dependent FMN reductase
JOS54_RS05435	COG3976	FMN-binding domain protein
JOS54_RS05435	COG1053	succinate dehydrogenase
JOS54_RS05440	COG2878	Part of a membrane complex involved in electron transport
JOS54_RS05450	COG4657	Part of a membrane complex involved in electron transport
JOS54_RS05455	COG4660	Part of a membrane complex involved in electron transport
JOS54_RS05465	COG4658	electron transport chain
JOS54_RS05470	COG4656	Part of a membrane complex involved in electron transport
JOS54_RS05480	COG1053	succinate dehydrogenase
JOS54_RS05480	COG3976	FMN-binding domain protein
JOS54_RS05495	COG1098	S1 RNA binding domain
JOS54_RS05500	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
JOS54_RS05505	COG0628	permease
JOS54_RS05515	COG1053	succinate dehydrogenase
JOS54_RS05520	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JOS54_RS05535	COG1799	cell septum assembly
JOS54_RS05550	COG0444	Belongs to the ABC transporter superfamily
JOS54_RS05555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JOS54_RS05560	COG0601	transmembrane transport
JOS54_RS05565	COG4166	transmembrane transport
JOS54_RS05695	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JOS54_RS05725	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JOS54_RS05730	COG2267	carboxylic ester hydrolase activity
JOS54_RS05735	COG2205	protein histidine kinase activity
JOS54_RS05735	COG2770	Histidine kinase
JOS54_RS05740	COG0745	RESPONSE REGULATOR receiver
JOS54_RS05745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JOS54_RS05755	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
JOS54_RS05910	COG0863	Belongs to the N(4) N(6)-methyltransferase family
JOS54_RS05985	COG1396	sequence-specific DNA binding
JOS54_RS05990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JOS54_RS05995	COG0582	viral genome integration into host DNA
JOS54_RS06010	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JOS54_RS06035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JOS54_RS06045	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JOS54_RS06075	COG1396	sequence-specific DNA binding
JOS54_RS06115	COG4974	Belongs to the 'phage' integrase family
JOS54_RS06140	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
JOS54_RS06165	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JOS54_RS06165	COG0551	DNA topoisomerase type I activity
JOS54_RS06245	COG1484	DNA-dependent DNA replication
JOS54_RS06255	COG0519	Catalyzes the synthesis of GMP from XMP
JOS54_RS06280	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JOS54_RS06285	COG0154	amidase activity
JOS54_RS06295	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JOS54_RS06300	COG0210	DNA helicase
JOS54_RS06305	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JOS54_RS06305	COG0116	Belongs to the methyltransferase superfamily
JOS54_RS06310	COG0564	pseudouridine synthase activity
JOS54_RS06325	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JOS54_RS06345	COG1105	Belongs to the carbohydrate kinase PfkB family
JOS54_RS06350	COG2195	Cleaves the N-terminal amino acid of tripeptides
JOS54_RS06355	COG1217	gtp-binding protein TYPA
JOS54_RS06365	COG0523	cobalamin synthesis protein
JOS54_RS06375	COG2272	Belongs to the type-B carboxylesterase lipase family
JOS54_RS06415	COG0583	DNA-binding transcription factor activity
JOS54_RS06420	COG1132	(ABC) transporter
JOS54_RS06425	COG1132	(ABC) transporter
JOS54_RS06460	COG3142	Participates in the control of copper homeostasis
JOS54_RS06465	COG1446	asparaginase
JOS54_RS06470	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JOS54_RS06480	COG2239	Acts as a magnesium transporter
JOS54_RS06490	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JOS54_RS06495	COG1363	Peptidase, m42
JOS54_RS06510	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JOS54_RS06515	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JOS54_RS06665	COG2801	Transposase and inactivated derivatives
JOS54_RS06700	COG1464	Belongs to the NlpA lipoprotein family
JOS54_RS06705	COG2011	ABC-type metal ion transport system permease component
JOS54_RS06710	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JOS54_RS06715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JOS54_RS06720	COG1968	undecaprenyl-diphosphatase activity
JOS54_RS06725	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
JOS54_RS06735	COG0776	regulation of translation
JOS54_RS06755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JOS54_RS06765	COG3842	ATPase activity
JOS54_RS06805	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JOS54_RS06810	COG0708	Exodeoxyribonuclease III
JOS54_RS06815	COG0006	proline dipeptidase activity
JOS54_RS06825	COG2816	NAD+ diphosphatase activity
JOS54_RS06835	COG0653	protein targeting
JOS54_RS06840	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JOS54_RS06850	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
JOS54_RS06880	COG1132	(ABC) transporter
JOS54_RS06885	COG1132	(ABC) transporter
JOS54_RS06895	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JOS54_RS06900	COG2183	response to ionizing radiation
JOS54_RS06920	COG4804	nuclease activity
JOS54_RS06925	COG2801	Transposase and inactivated derivatives
JOS54_RS06935	COG0420	3'-5' exonuclease activity
JOS54_RS06960	COG1362	aminopeptidase activity
JOS54_RS06965	COG2309	aminopeptidase activity
JOS54_RS07000	COG3958	Transketolase
JOS54_RS07005	COG3959	Transketolase, thiamine diphosphate binding domain
JOS54_RS07010	COG0577	efflux transmembrane transporter activity
JOS54_RS07015	COG1136	(ABC) transporter
JOS54_RS07020	COG2205	protein histidine kinase activity
JOS54_RS07025	COG0745	RESPONSE REGULATOR receiver
JOS54_RS07035	COG0745	RESPONSE REGULATOR receiver
JOS54_RS07045	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JOS54_RS07055	COG4122	O-methyltransferase activity
JOS54_RS07075	COG1940	carbohydrate kinase activity
JOS54_RS07095	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
JOS54_RS07100	COG1940	carbohydrate kinase activity
JOS54_RS07105	COG1045	serine acetyltransferase
JOS54_RS07115	COG0203	ribosomal protein L17
JOS54_RS07120	COG0202	RNA polymerase activity
JOS54_RS07125	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JOS54_RS07130	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JOS54_RS07150	COG0201	protein transport
JOS54_RS07155	COG0200	Binds to the 23S rRNA
JOS54_RS07160	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JOS54_RS07165	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JOS54_RS07170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JOS54_RS07180	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JOS54_RS07190	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JOS54_RS07195	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JOS54_RS07200	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JOS54_RS07205	COG0255	Belongs to the universal ribosomal protein uL29 family
JOS54_RS07210	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JOS54_RS07215	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JOS54_RS07220	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JOS54_RS07230	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JOS54_RS07235	COG0089	rRNA binding
JOS54_RS07240	COG0088	Forms part of the polypeptide exit tunnel
JOS54_RS07245	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JOS54_RS07265	COG1011	Hydrolase
JOS54_RS07285	COG3716	PTS system mannose fructose sorbose family IID component
JOS54_RS07290	COG3715	PTS system
JOS54_RS07295	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JOS54_RS07310	COG2222	sugar isomerase
JOS54_RS07315	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JOS54_RS07330	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JOS54_RS07335	COG0049	tRNA binding
JOS54_RS07340	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JOS54_RS07345	COG3842	ATPase activity
JOS54_RS07375	COG0058	SHG alpha-glucan phosphorylase activity
JOS54_RS07390	COG1373	ATPase (AAA superfamily
JOS54_RS07435	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
JOS54_RS07440	COG1846	Transcriptional regulator
JOS54_RS07465	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JOS54_RS07470	COG1882	Formate acetyltransferase
JOS54_RS07475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JOS54_RS07480	COG1126	abc transporter atp-binding protein
JOS54_RS07485	COG0765	amino acid transport
JOS54_RS07490	COG0673	inositol 2-dehydrogenase activity
JOS54_RS07495	COG0561	phosphatase activity
JOS54_RS07505	COG3859	Proton-coupled thiamine transporter YuaJ
JOS54_RS07540	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JOS54_RS07545	COG0569	domain protein
JOS54_RS07555	COG0670	Belongs to the BI1 family
JOS54_RS07560	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JOS54_RS07565	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
JOS54_RS07570	COG1739	Uncharacterized protein family UPF0029
JOS54_RS07575	COG5492	domain, Protein
JOS54_RS07590	COG3853	Toxic anion resistance protein (TelA)
JOS54_RS07595	COG2755	lipolytic protein G-D-S-L family
JOS54_RS07595	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JOS54_RS07600	COG2755	lipolytic protein G-D-S-L family
JOS54_RS07600	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JOS54_RS07605	COG0464	growth
JOS54_RS07650	COG4555	ABC transporter
JOS54_RS07665	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
JOS54_RS07670	COG1074	ATP-dependent DNA helicase activity
JOS54_RS07710	COG2205	protein histidine kinase activity
JOS54_RS07720	COG1592	Rubrerythrin
JOS54_RS07740	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
JOS54_RS07745	COG1774	PSP1 C-terminal conserved region
JOS54_RS07755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JOS54_RS07780	COG3639	organic phosphonate transmembrane transporter activity
JOS54_RS07785	COG3639	organic phosphonate transmembrane transporter activity
JOS54_RS07795	COG0737	Belongs to the 5'-nucleotidase family
JOS54_RS07810	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JOS54_RS07815	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JOS54_RS07820	COG0193	aminoacyl-tRNA hydrolase activity
JOS54_RS07835	COG0230	Belongs to the bacterial ribosomal protein bL34 family
JOS54_RS07840	COG0594	ribonuclease P activity
JOS54_RS07850	COG1847	R3H domain protein