locus-tag	class	description
K562_RS00020	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K562_RS00020	COG0519	Catalyzes the synthesis of GMP from XMP
K562_RS00025	COG1902	pentaerythritol trinitrate reductase activity
K562_RS00035	COG0642	Histidine kinase
K562_RS00050	COG2154	pterin-4-alpha-carbinolamine dehydratase
K562_RS00055	COG3186	Phenylalanine-4-hydroxylase
K562_RS00060	COG1522	sequence-specific DNA binding
K562_RS00070	COG0583	DNA-binding transcription factor activity
K562_RS00075	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
K562_RS00125	COG0445	tRNA wobble uridine modification
K562_RS00130	COG0357	Ribosomal RNA small subunit methyltransferase G
K562_RS00135	COG1192	Involved in chromosome partitioning
K562_RS00140	COG1475	DNA binding
K562_RS00145	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
K562_RS00155	COG0356	it plays a direct role in the translocation of protons across the membrane
K562_RS00170	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
K562_RS00175	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
K562_RS00180	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
K562_RS00185	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
K562_RS00190	COG0355	proton-transporting ATP synthase activity, rotational mechanism
K562_RS00195	COG0318	PFAM AMP-dependent synthetase and ligase
K562_RS00210	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
K562_RS00215	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
K562_RS00220	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
K562_RS00220	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
K562_RS00220	COG0506	proline dehydrogenase activity
K562_RS00225	COG0683	leucine binding
K562_RS00240	COG1960	acyl-CoA dehydrogenase activity
K562_RS00250	COG0436	Aminotransferase
K562_RS00260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K562_RS00265	COG0277	FAD linked oxidase domain protein
K562_RS00275	COG0789	Transcriptional regulator
K562_RS00295	COG0668	transmembrane transport
K562_RS00300	COG0531	amino acid
K562_RS00305	COG4303	Ethanolamine ammonia lyase large subunit
K562_RS00310	COG4302	ethanolamine ammonia-lyase activity
K562_RS00315	COG0583	DNA-binding transcription factor activity
K562_RS00330	COG1012	belongs to the aldehyde dehydrogenase family
K562_RS00350	COG0028	Belongs to the TPP enzyme family
K562_RS00365	COG1760	l-serine dehydratase
K562_RS00375	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K562_RS00375	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
K562_RS00380	COG0509	glycine decarboxylation via glycine cleavage system
K562_RS00385	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K562_RS00395	COG0673	inositol 2-dehydrogenase activity
K562_RS00405	COG0210	DNA helicase
K562_RS00420	COG0582	viral genome integration into host DNA
K562_RS00455	COG3344	reverse transcriptase
K562_RS00585	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K562_RS00610	COG0519	Catalyzes the synthesis of GMP from XMP
K562_RS00625	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K562_RS00630	COG2916	Histone family protein nucleoid-structuring protein H-NS
K562_RS00635	COG0438	transferase activity, transferring glycosyl groups
K562_RS00660	COG1360	Flagellar Motor Protein
K562_RS00665	COG0745	RESPONSE REGULATOR receiver
K562_RS00680	COG0840	transmembrane signaling receptor activity
K562_RS00685	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
K562_RS00700	COG0745	RESPONSE REGULATOR receiver
K562_RS00705	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
K562_RS00725	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K562_RS00730	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K562_RS00745	COG1191	sigma factor activity
K562_RS00755	COG1950	PFAM Membrane protein of
K562_RS00760	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
K562_RS00805	COG1522	sequence-specific DNA binding
K562_RS00815	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K562_RS00835	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
K562_RS00840	COG2823	Periplasmic or secreted lipoprotein
K562_RS00885	COG5314	conjugation
K562_RS00895	COG3846	protein secretion by the type IV secretion system
K562_RS00905	COG3093	addiction module antidote protein HigA
K562_RS00945	COG2271	Major facilitator Superfamily
K562_RS00950	COG0583	DNA-binding transcription factor activity
K562_RS00965	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
K562_RS00970	COG0577	efflux transmembrane transporter activity
K562_RS00980	COG1136	(ABC) transporter
K562_RS00980	COG0577	efflux transmembrane transporter activity
K562_RS01000	COG2084	Dehydrogenase
K562_RS01005	COG1280	lysine exporter protein (LysE YggA)
K562_RS01010	COG2814	Major facilitator Superfamily
K562_RS01015	COG0583	DNA-binding transcription factor activity
K562_RS01020	COG3047	cAMP biosynthetic process
K562_RS01035	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K562_RS01045	COG1881	PFAM PEBP family protein
K562_RS01050	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
K562_RS01055	COG0280	phosphate acetyltransferase
K562_RS01055	COG0281	malic enzyme
K562_RS01075	COG1522	sequence-specific DNA binding
K562_RS01095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K562_RS01100	COG2151	metal-sulfur cluster biosynthetic enzyme
K562_RS01105	COG3396	Phenylacetate-CoA oxygenase
K562_RS01110	COG3460	Phenylacetate-CoA oxygenase
K562_RS01115	COG3396	Phenylacetate-CoA oxygenase
K562_RS01170	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K562_RS01180	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
K562_RS01195	COG0081	regulation of translation
K562_RS01200	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
K562_RS01205	COG0222	ribosome binding
K562_RS01210	COG0085	RNA polymerase activity
K562_RS01215	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
K562_RS01220	COG0514	ATP-dependent DNA helicase (RecQ)
K562_RS01240	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
K562_RS01255	COG0088	Forms part of the polypeptide exit tunnel
K562_RS01335	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
K562_RS01345	COG0200	Binds to the 23S rRNA
K562_RS01350	COG0201	protein transport
K562_RS01365	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
K562_RS01395	COG4232	protein-disulfide reductase activity
K562_RS01415	COG1333	cytochrome c biogenesis protein
K562_RS01420	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
K562_RS01425	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K562_RS01430	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
K562_RS01440	COG1965	Belongs to the frataxin family
K562_RS01475	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
K562_RS01480	COG0232	Belongs to the dGTPase family. Type 2 subfamily
K562_RS01485	COG1653	transport
K562_RS01490	COG1175	transmembrane transport
K562_RS01495	COG0395	ABC-type sugar transport system, permease component
K562_RS01505	COG0584	glycerophosphoryl diester phosphodiesterase
K562_RS01520	COG0070	glutamate synthase
K562_RS01520	COG0069	glutamate synthase activity
K562_RS01520	COG0067	glutamate synthase
K562_RS01530	COG1115	amino acid carrier protein
K562_RS01540	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K562_RS01545	COG2814	Major facilitator Superfamily
K562_RS01550	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS01555	COG4178	(ABC) transporter
K562_RS01580	COG1127	ABC transporter
K562_RS01585	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K562_RS01590	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K562_RS01610	COG1131	(ABC) transporter
K562_RS01615	COG0842	Transport permease protein
K562_RS01650	COG2095	MarC family integral membrane protein
K562_RS01665	COG0107	imidazoleglycerol-phosphate synthase activity
K562_RS01670	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
K562_RS01700	COG0805	protein transport
K562_RS01705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K562_RS01710	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
K562_RS01715	COG0723	plastoquinol--plastocyanin reductase activity
K562_RS01720	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
K562_RS01725	COG2857	Cytochrome c1
K562_RS01730	COG0625	glutathione transferase activity
K562_RS01735	COG2969	positive regulation of protein catabolic process
K562_RS01750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K562_RS01870	COG0308	aminopeptidase N
K562_RS01880	COG3422	double-strand break repair
K562_RS01885	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
K562_RS01900	COG1309	transcriptional regulator
K562_RS01915	COG0443	Heat shock 70 kDa protein
K562_RS01920	COG1278	Cold shock
K562_RS01925	COG0531	amino acid
K562_RS01930	COG3384	dioxygenase
K562_RS01940	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
K562_RS01945	COG2890	protein-(glutamine-N5) methyltransferase activity
K562_RS01950	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
K562_RS01955	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
K562_RS01970	COG0006	proline dipeptidase activity
K562_RS01975	COG1335	isochorismatase
K562_RS01985	COG0488	(ABC) transporter
K562_RS01995	COG0583	DNA-binding transcription factor activity
K562_RS02020	COG0012	GTP binding
K562_RS02025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K562_RS02030	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K562_RS02045	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
K562_RS02060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K562_RS02065	COG0512	Glutamine amidotransferase of anthranilate synthase
K562_RS02075	COG0546	phosphoglycolate phosphatase activity
K562_RS02080	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
K562_RS02085	COG2967	ApaG domain
K562_RS02090	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
K562_RS02100	COG2050	protein possibly involved in aromatic compounds catabolism
K562_RS02105	COG1024	Enoyl-CoA hydratase
K562_RS02110	COG0183	Belongs to the thiolase family
K562_RS02120	COG1024	Enoyl-CoA hydratase
K562_RS02185	COG0592	DNA-directed DNA polymerase activity
K562_RS02190	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K562_RS02205	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
K562_RS02210	COG0706	membrane insertase activity
K562_RS02225	COG2203	Gaf domain
K562_RS02225	COG3706	GGDEF domain
K562_RS02225	COG4251	negative regulation of phosphorylation
K562_RS02225	COG5001	Diguanylate cyclase
K562_RS02240	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K562_RS02260	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K562_RS02260	COG2169	Transcriptional regulator
K562_RS02280	COG1620	l-lactate permease
K562_RS02285	COG0583	DNA-binding transcription factor activity
K562_RS02290	COG3511	phospholipase C
K562_RS02300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K562_RS02315	COG3842	ATPase activity
K562_RS02320	COG1840	ABC-type Fe3 transport system, periplasmic component
K562_RS02330	COG1012	belongs to the aldehyde dehydrogenase family
K562_RS02335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K562_RS02340	COG0765	amino acid transport
K562_RS02345	COG1126	abc transporter atp-binding protein
K562_RS02380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K562_RS02385	COG0583	DNA-binding transcription factor activity
K562_RS02400	COG0758	DNA mediated transformation
K562_RS02405	COG0242	peptide deformylase activity
K562_RS02410	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K562_RS02420	COG0501	Belongs to the peptidase M48B family
K562_RS02435	COG5000	phosphorelay sensor kinase activity
K562_RS02440	COG2204	response regulator
K562_RS02450	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
K562_RS02455	COG0602	queuosine metabolic process
K562_RS02460	COG0720	synthase
K562_RS02475	COG0772	Belongs to the SEDS family
K562_RS02480	COG0768	penicillin binding
K562_RS02495	COG1077	Cell shape determining protein MreB Mrl
K562_RS02500	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K562_RS02505	COG0154	amidase activity
K562_RS02510	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
K562_RS02515	COG2326	polyphosphate kinase activity
K562_RS02520	COG0708	Exodeoxyribonuclease III
K562_RS02525	COG1064	alcohol dehydrogenase
K562_RS02530	COG2207	Transcriptional regulator
K562_RS02540	COG2814	Major facilitator Superfamily
K562_RS02545	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K562_RS02550	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
K562_RS02580	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
K562_RS02585	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
K562_RS02590	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
K562_RS02600	COG0523	cobalamin synthesis protein
K562_RS02610	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
K562_RS02620	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K562_RS02625	COG1560	Kdo2-lipid A biosynthetic process
K562_RS02630	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
K562_RS02650	COG0667	Aldo Keto reductase
K562_RS02720	COG1677	Flagellar hook-basal body complex protein FliE
K562_RS02740	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K562_RS02755	COG0531	amino acid
K562_RS02760	COG2197	response regulator
K562_RS02775	COG3568	Endonuclease Exonuclease Phosphatase
K562_RS02790	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K562_RS02795	COG0579	oxidoreductase
K562_RS02810	COG0747	negative chemotaxis
K562_RS02815	COG0601	transmembrane transport
K562_RS02820	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K562_RS02825	COG0444	Belongs to the ABC transporter superfamily
K562_RS02830	COG4608	Belongs to the ABC transporter superfamily
K562_RS02845	COG1984	allophanate hydrolase subunit 2
K562_RS02850	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
K562_RS02860	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
K562_RS02865	COG0741	lytic transglycosylase activity
K562_RS02880	COG0617	tRNA 3'-terminal CCA addition
K562_RS02890	COG0006	proline dipeptidase activity
K562_RS02910	COG1815	bacterial-type flagellum-dependent cell motility
K562_RS02915	COG1558	bacterial-type flagellum-dependent cell motility
K562_RS02920	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
K562_RS02940	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
K562_RS02945	COG1706	bacterial-type flagellum-dependent cell motility
K562_RS02955	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
K562_RS02965	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
K562_RS02970	COG2233	PERMEase
K562_RS03000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS03040	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K562_RS03045	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K562_RS03055	COG1177	transmembrane transport
K562_RS03060	COG1176	ABC-type spermidine putrescine transport system, permease component I
K562_RS03065	COG3842	ATPase activity
K562_RS03080	COG0174	glutamine synthetase
K562_RS03085	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K562_RS03095	COG1012	belongs to the aldehyde dehydrogenase family
K562_RS03110	COG0672	)-iron permease
K562_RS03135	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K562_RS03140	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K562_RS03185	COG1609	Transcriptional regulator
K562_RS03210	COG0583	DNA-binding transcription factor activity
K562_RS03220	COG0596	Alpha beta hydrolase
K562_RS03225	COG1522	sequence-specific DNA binding
K562_RS03250	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K562_RS03270	COG2080	2 iron, 2 sulfur cluster binding
K562_RS03275	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
K562_RS03280	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K562_RS03285	COG0583	DNA-binding transcription factor activity
K562_RS03290	COG0625	glutathione transferase activity
K562_RS03315	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K562_RS03335	COG0625	glutathione transferase activity
K562_RS03350	COG0025	NhaP-type Na H and K H
K562_RS03355	COG2200	EAL domain
K562_RS03355	COG2199	diguanylate cyclase activity
K562_RS03385	COG1984	allophanate hydrolase subunit 2
K562_RS03395	COG0439	Biotin carboxylase
K562_RS03400	COG0511	ligase activity, forming carbon-carbon bonds
K562_RS03405	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K562_RS03415	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
K562_RS03420	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K562_RS03425	COG0156	8-amino-7-oxononanoate synthase activity
K562_RS03440	COG3012	SEC-C Motif Domain Protein
K562_RS03445	COG0300	oxidoreductase activity
K562_RS03450	COG0288	reversible hydration of carbon dioxide
K562_RS03465	COG0488	(ABC) transporter
K562_RS03470	COG0747	negative chemotaxis
K562_RS03475	COG0300	oxidoreductase activity
K562_RS03480	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K562_RS03490	COG0018	arginyl-trna synthetase
K562_RS03530	COG1024	Enoyl-CoA hydratase
K562_RS03550	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
K562_RS03560	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
K562_RS03565	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
K562_RS03565	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
K562_RS03575	COG0737	Belongs to the 5'-nucleotidase family
K562_RS03580	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
K562_RS03585	COG1127	ABC transporter
K562_RS03615	COG1686	Belongs to the peptidase S11 family
K562_RS03625	COG2921	Belongs to the UPF0250 family
K562_RS03630	COG0583	DNA-binding transcription factor activity
K562_RS03650	COG4521	taurine ABC transporter
K562_RS03660	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K562_RS03665	COG0405	Gamma-glutamyltransferase
K562_RS03670	COG0583	DNA-binding transcription factor activity
K562_RS03680	COG1960	acyl-CoA dehydrogenase activity
K562_RS03685	COG1960	acyl-CoA dehydrogenase activity
K562_RS03690	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K562_RS03700	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K562_RS03710	COG4191	Histidine kinase
K562_RS03730	COG0606	chelatase, subunit chli
K562_RS03735	COG2960	long-chain fatty acid transporting porin activity
K562_RS03745	COG0004	ammonium transporteR
K562_RS03755	COG0189	ligase activity
K562_RS03765	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
K562_RS03770	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
K562_RS03775	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
K562_RS03780	COG0793	Belongs to the peptidase S41A family
K562_RS03785	COG0588	phosphoglycerate mutase activity
K562_RS03790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K562_RS03800	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
K562_RS03805	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K562_RS03810	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
K562_RS03820	COG1040	competence protein
K562_RS03825	COG2226	methyltransferase
K562_RS03840	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
K562_RS03850	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
K562_RS03880	COG1612	heme a metabolic process
K562_RS03890	COG1999	signal sequence binding
K562_RS03900	COG0840	transmembrane signaling receptor activity
K562_RS03925	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
K562_RS03940	COG0587	DNA-directed DNA polymerase activity
K562_RS03950	COG4977	sequence-specific DNA binding
K562_RS03955	COG2031	fatty acid transporter
K562_RS03965	COG0243	molybdopterin cofactor binding
K562_RS03970	COG0583	DNA-binding transcription factor activity
K562_RS03975	COG2188	Transcriptional regulator
K562_RS03980	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
K562_RS03985	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K562_RS03995	COG1263	PTS System
K562_RS03995	COG2190	(PTS) system
K562_RS03995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
K562_RS04010	COG1294	oxidase, subunit
K562_RS04025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K562_RS04040	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K562_RS04045	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
K562_RS04050	COG0625	glutathione transferase activity
K562_RS04060	COG0742	ribosomal rna small subunit methyltransferase
K562_RS04070	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
K562_RS04090	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
K562_RS04100	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
K562_RS04105	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
K562_RS04115	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
K562_RS04120	COG1194	a g-specific adenine glycosylase
K562_RS04130	COG1660	Displays ATPase and GTPase activities
K562_RS04145	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
K562_RS04150	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
K562_RS04155	COG1137	ATPase activity
K562_RS04170	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
K562_RS04190	COG1280	lysine exporter protein (LysE YggA)
K562_RS04215	COG2814	Major facilitator Superfamily
K562_RS04220	COG0629	single-stranded DNA binding
K562_RS04225	COG3663	DNA glycosylase
K562_RS04245	COG0183	Belongs to the thiolase family
K562_RS04250	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS04275	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K562_RS04300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
K562_RS04315	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS04330	COG0501	Belongs to the peptidase M48B family
K562_RS04335	COG1620	l-lactate permease
K562_RS04340	COG1139	Iron-sulfur cluster binding protein
K562_RS04350	COG0247	lactate metabolic process
K562_RS04355	COG2186	Transcriptional regulator
K562_RS04360	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K562_RS04365	COG0235	Class ii aldolase
K562_RS04390	COG0477	Major facilitator Superfamily
K562_RS04410	COG1737	Transcriptional regulator
K562_RS04410	COG0837	glucose binding
K562_RS04415	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K562_RS04420	COG0251	oxidation-reduction process
K562_RS04425	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K562_RS04425	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
K562_RS04430	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K562_RS04470	COG0500	methyltransferase
K562_RS04485	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
K562_RS04490	COG0494	nUDIX hydrolase
K562_RS04505	COG1960	acyl-CoA dehydrogenase activity
K562_RS04510	COG1024	Enoyl-CoA hydratase
K562_RS04510	COG1250	3-hydroxyacyl-CoA dehydrogenase
K562_RS04515	COG0183	Belongs to the thiolase family
K562_RS04520	COG1024	Enoyl-CoA hydratase
K562_RS04525	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
K562_RS04540	COG5265	(ABC) transporter
K562_RS04565	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
K562_RS04570	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
K562_RS04590	COG0204	Acyl-transferase
K562_RS04595	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
K562_RS04600	COG0751	glycine-tRNA ligase activity
K562_RS04605	COG0752	glycyl-tRNA synthetase alpha subunit
K562_RS04615	COG0815	Transfers the fatty acyl group on membrane lipoproteins
K562_RS04630	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
K562_RS04640	COG1702	phosphate starvation-inducible protein PhoH
K562_RS04645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K562_RS04650	COG0583	DNA-binding transcription factor activity
K562_RS04655	COG2814	Major facilitator Superfamily
K562_RS04660	COG1396	sequence-specific DNA binding
K562_RS04670	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K562_RS04675	COG0673	inositol 2-dehydrogenase activity
K562_RS04690	COG1609	Transcriptional regulator
K562_RS04710	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
K562_RS04755	COG0513	Belongs to the DEAD box helicase family
K562_RS04765	COG2863	cytochrome
K562_RS04775	COG4948	Mandelate Racemase Muconate Lactonizing
K562_RS04780	COG2186	Transcriptional regulator
K562_RS04785	COG3813	Protein conserved in bacteria
K562_RS04800	COG0583	DNA-binding transcription factor activity
K562_RS04820	COG4977	sequence-specific DNA binding
K562_RS04825	COG0583	DNA-binding transcription factor activity
K562_RS04870	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
K562_RS04875	COG2137	regulation of response to DNA damage stimulus
K562_RS04885	COG0045	succinate-CoA ligase (ADP-forming) activity
K562_RS04890	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
K562_RS04895	COG0861	Integral membrane protein TerC family
K562_RS04900	COG4969	Belongs to the N-Me-Phe pilin family
K562_RS04915	COG0315	cyclic pyranopterin monophosphate synthase activity
K562_RS04920	COG4783	chaperone-mediated protein folding
K562_RS04930	COG0429	hydrolase of the alpha beta-hydrolase fold
K562_RS04965	COG0126	phosphoglycerate kinase activity
K562_RS04970	COG0469	pyruvate kinase activity
K562_RS04980	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
K562_RS04985	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
K562_RS04990	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
K562_RS04995	COG0009	L-threonylcarbamoyladenylate synthase
K562_RS05010	COG2027	D-alanyl-D-alanine carboxypeptidase
K562_RS05025	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K562_RS05045	COG4977	sequence-specific DNA binding
K562_RS05065	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K562_RS05075	COG2233	PERMEase
K562_RS05080	COG1070	Carbohydrate kinase
K562_RS05090	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K562_RS05095	COG1108	ABC-type Mn2 Zn2 transport systems permease components
K562_RS05100	COG1121	(ABC) transporter
K562_RS05110	COG0735	belongs to the Fur family
K562_RS05120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K562_RS05125	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
K562_RS05135	COG4209	transmembrane transport
K562_RS05145	COG0546	phosphoglycolate phosphatase activity
K562_RS05150	COG3842	ATPase activity
K562_RS05155	COG0583	DNA-binding transcription factor activity
K562_RS05170	COG2390	Transcriptional regulator
K562_RS05175	COG1070	Carbohydrate kinase
K562_RS05180	COG0246	Mannitol dehydrogenase
K562_RS05195	COG1012	belongs to the aldehyde dehydrogenase family
K562_RS05200	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K562_RS05210	COG3483	tryptophan 2,3-dioxygenase activity
K562_RS05220	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
K562_RS05225	COG1522	sequence-specific DNA binding
K562_RS05230	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K562_RS05245	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K562_RS05255	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
K562_RS05260	COG0259	pyridoxamine-phosphate oxidase activity
K562_RS05265	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
K562_RS05275	COG1741	Belongs to the pirin family
K562_RS05285	COG0860	N-Acetylmuramoyl-L-alanine amidase
K562_RS05290	COG0802	atpase or kinase
K562_RS05295	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
K562_RS05305	COG4974	Belongs to the 'phage' integrase family
K562_RS05310	COG0318	PFAM AMP-dependent synthetase and ligase
K562_RS05315	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K562_RS05320	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
K562_RS05325	COG1666	GTP binding
K562_RS05350	COG0728	peptidoglycan biosynthetic process
K562_RS05365	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
K562_RS05375	COG1663	tetraacyldisaccharide 4'-kinase activity
K562_RS05380	COG1570	exodeoxyribonuclease VII activity
K562_RS05385	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
K562_RS05410	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K562_RS05425	COG2814	Major facilitator Superfamily
K562_RS05440	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K562_RS05445	COG2188	Transcriptional regulator
K562_RS05450	COG0656	L-ascorbic acid biosynthetic process
K562_RS05460	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
K562_RS05505	COG1278	Cold shock
K562_RS05520	COG0542	response to heat
K562_RS05525	COG1113	amino acid transport
K562_RS05535	COG0756	dUTP diphosphatase activity
K562_RS05540	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
K562_RS05545	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
K562_RS05550	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
K562_RS05555	COG0196	riboflavin kinase activity
K562_RS05560	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
K562_RS05565	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
K562_RS05565	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
K562_RS05570	COG3264	Mechanosensitive ion channel
K562_RS05570	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
K562_RS05590	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K562_RS05610	COG1047	Peptidyl-prolyl cis-trans
K562_RS05615	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
K562_RS05655	COG0456	acetyltransferase
K562_RS05660	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K562_RS05680	COG1187	pseudouridine synthase activity
K562_RS05695	COG4221	oxidoreductase activity
K562_RS05700	COG0583	DNA-binding transcription factor activity
K562_RS05715	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS05720	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS05740	COG0583	DNA-binding transcription factor activity
K562_RS05755	COG0175	sulfate reduction
K562_RS05765	COG2895	sulfate adenylyltransferase (ATP) activity
K562_RS05770	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
K562_RS05770	COG1648	precorrin-2 dehydrogenase activity
K562_RS05790	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
K562_RS05805	COG4654	Cytochrome c, class I
K562_RS05815	COG0583	DNA-binding transcription factor activity
K562_RS05820	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
K562_RS05850	COG4139	cobalamin transport
K562_RS05855	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K562_RS05860	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
K562_RS05865	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
K562_RS05875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
K562_RS05885	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
K562_RS05895	COG1492	cobalamin metabolic process
K562_RS05905	COG2259	Doxx family
K562_RS05915	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
K562_RS05920	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
K562_RS05925	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
K562_RS05945	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K562_RS05945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K562_RS05950	COG2885	chlorophyll binding
K562_RS05950	COG3047	cAMP biosynthetic process
K562_RS05955	COG0489	protein tyrosine kinase activity
K562_RS05980	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
K562_RS05985	COG0165	Argininosuccinate lyase
K562_RS06015	COG2226	methyltransferase
K562_RS06020	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
K562_RS06025	COG0181	hydroxymethylbilane synthase activity
K562_RS06040	COG0596	Alpha beta hydrolase
K562_RS06050	COG2271	Major facilitator Superfamily
K562_RS06065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
K562_RS06080	COG1472	Belongs to the glycosyl hydrolase 3 family
K562_RS06105	COG0583	DNA-binding transcription factor activity
K562_RS06135	COG1741	Belongs to the pirin family
K562_RS06160	COG1176	ABC-type spermidine putrescine transport system, permease component I
K562_RS06195	COG2814	Major facilitator Superfamily
K562_RS06220	COG1309	transcriptional regulator
K562_RS06225	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS06255	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K562_RS06280	COG0488	(ABC) transporter
K562_RS06300	COG0583	DNA-binding transcription factor activity
K562_RS06310	COG2059	Chromate
K562_RS06315	COG5001	Diguanylate cyclase
K562_RS06320	COG0384	phenazine biosynthesis protein PhzF
K562_RS06330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K562_RS06335	COG0697	spore germination
K562_RS06375	COG4106	trans-aconitate 2-methyltransferase activity
K562_RS06395	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
K562_RS06400	COG3135	benzoate transporter
K562_RS06410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K562_RS06435	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
K562_RS06440	COG2878	Part of a membrane complex involved in electron transport
K562_RS06445	COG1309	transcriptional regulator
K562_RS06460	COG3387	PFAM Glycoside hydrolase 15-related
K562_RS06465	COG2706	6-phosphogluconolactonase activity
K562_RS06490	COG3895	Periplasmic Protein
K562_RS06495	COG0513	Belongs to the DEAD box helicase family
K562_RS06500	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K562_RS06505	COG1054	Belongs to the UPF0176 family
K562_RS06540	COG0859	PFAM glycosyl transferase family 9
K562_RS06545	COG0463	Glycosyl transferase, family 2
K562_RS06575	COG3171	Protein conserved in bacteria
K562_RS06580	COG1530	ribonuclease E activity
K562_RS06590	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
K562_RS06595	COG0799	negative regulation of ribosome biogenesis
K562_RS06600	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
K562_RS06605	COG0408	coproporphyrinogen oxidase activity
K562_RS06610	COG0151	Belongs to the GarS family
K562_RS06620	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
K562_RS06625	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS06645	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
K562_RS06650	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
K562_RS06655	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
K562_RS06660	COG2205	protein histidine kinase activity
K562_RS06665	COG0745	RESPONSE REGULATOR receiver
K562_RS06700	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K562_RS06710	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K562_RS06715	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS06735	COG0438	transferase activity, transferring glycosyl groups
K562_RS06765	COG0028	Belongs to the TPP enzyme family
K562_RS06775	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
K562_RS06780	COG0688	phosphatidylethanolamine metabolic process
K562_RS06785	COG1183	phosphatidylcholine synthase activity
K562_RS06790	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K562_RS06795	COG0659	secondary active sulfate transmembrane transporter activity
K562_RS06800	COG0288	reversible hydration of carbon dioxide
K562_RS06810	COG0683	leucine binding
K562_RS06820	COG1185	polyribonucleotide nucleotidyltransferase activity
K562_RS06825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K562_RS06825	COG4221	oxidoreductase activity
K562_RS06825	COG3321	synthase
K562_RS06825	COG0604	alcohol dehydrogenase
K562_RS06830	COG0149	triose-phosphate isomerase activity
K562_RS06865	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
K562_RS06875	COG1034	ATP synthesis coupled electron transport
K562_RS06875	COG1034	ATP synthesis coupled electron transport
K562_RS06880	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
K562_RS06885	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
K562_RS06910	COG1007	ATP synthesis coupled electron transport
K562_RS06930	COG1960	acyl-CoA dehydrogenase activity
K562_RS06935	COG1960	acyl-CoA dehydrogenase activity
K562_RS06950	COG0625	glutathione transferase activity
K562_RS06955	COG1024	Enoyl-CoA hydratase
K562_RS06965	COG0436	Aminotransferase
K562_RS06975	COG3022	response to hydroperoxide
K562_RS06980	COG2866	Carboxypeptidase
K562_RS07045	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
K562_RS07050	COG0667	Aldo Keto reductase
K562_RS07055	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS07065	COG0556	nucleotide-excision repair
K562_RS07075	COG4633	Protein conserved in bacteria
K562_RS07080	COG0672	)-iron permease
K562_RS07100	COG1741	Belongs to the pirin family
K562_RS07130	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
K562_RS07165	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K562_RS07190	COG3328	transposase activity
K562_RS07230	COG2304	oxidoreductase activity
K562_RS07240	COG2310	stress, protein
K562_RS07280	COG2895	sulfate adenylyltransferase (ATP) activity
K562_RS07280	COG0529	Catalyzes the synthesis of activated sulfate
K562_RS07300	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS07320	COG0415	Belongs to the DNA photolyase family
K562_RS07330	COG0583	DNA-binding transcription factor activity
K562_RS07350	COG2986	histidine ammonia-lyase
K562_RS07360	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
K562_RS07370	COG1228	amidohydrolase
K562_RS07385	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K562_RS07390	COG0174	glutamine synthetase
K562_RS07405	COG0583	DNA-binding transcription factor activity
K562_RS07410	COG1960	acyl-CoA dehydrogenase activity
K562_RS07415	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K562_RS07420	COG0477	Major facilitator Superfamily
K562_RS07430	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
K562_RS07430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K562_RS07435	COG1643	Atp-dependent helicase
K562_RS07455	COG1058	Belongs to the CinA family
K562_RS07455	COG1546	Belongs to the CinA family
K562_RS07465	COG0174	glutamine synthetase
K562_RS07480	COG1505	serine-type exopeptidase activity
K562_RS07500	COG2963	transposase activity
K562_RS07505	COG3436	PFAM IS66 Orf2 family protein
K562_RS07510	COG4372	Transposase
K562_RS07520	COG1794	racemase activity, acting on amino acids and derivatives
K562_RS07525	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
K562_RS07530	COG0339	signal peptide processing
K562_RS07535	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
K562_RS07540	COG4566	intracellular signal transduction
K562_RS07550	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K562_RS07555	COG0508	dehydrogenase complex catalyzes the overall conversion of
K562_RS07560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K562_RS07585	COG1414	Transcriptional regulator
K562_RS07605	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K562_RS07615	COG1104	cysteine desulfurase activity
K562_RS07620	COG0822	iron-sulfur transferase activity
K562_RS07625	COG0316	Belongs to the HesB IscA family
K562_RS07630	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
K562_RS07635	COG0443	Heat shock 70 kDa protein
K562_RS07655	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
K562_RS07665	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
K562_RS07685	COG0084	hydrolase, TatD family'
K562_RS07690	COG2333	competence protein COMEC
K562_RS07690	COG0658	competence protein
K562_RS07705	COG2877	3-deoxy-8-phosphooctulonate synthase activity
K562_RS07715	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
K562_RS07725	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
K562_RS07735	COG2833	Protein of unknown function (DUF455)
K562_RS07740	COG0596	Alpha beta hydrolase
K562_RS07745	COG0613	PHP domain protein
K562_RS07750	COG0009	L-threonylcarbamoyladenylate synthase
K562_RS07755	COG1994	Peptidase M50
K562_RS07760	COG0180	Tryptophanyl-tRNA synthetase
K562_RS07770	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K562_RS07775	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K562_RS07780	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K562_RS07790	COG2850	peptidyl-arginine hydroxylation
K562_RS07805	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
K562_RS07815	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
K562_RS07820	COG0483	inositol monophosphate 1-phosphatase activity
K562_RS07830	COG1045	serine acetyltransferase
K562_RS07835	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K562_RS07845	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
K562_RS07855	COG0215	cysteine-tRNA ligase activity
K562_RS07870	COG0037	tRNA processing
K562_RS07875	COG0527	aspartate kinase activity
K562_RS07915	COG0745	RESPONSE REGULATOR receiver
K562_RS07920	COG0642	Histidine kinase
K562_RS07960	COG4174	ABC transporter (Permease)
K562_RS07965	COG4239	(ABC) transporter, permease
K562_RS07970	COG4172	Belongs to the ABC transporter superfamily
K562_RS07975	COG0791	NLP P60 protein
K562_RS07980	COG1752	Esterase of the alpha-beta hydrolase superfamily
K562_RS07985	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K562_RS08040	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K562_RS08050	COG0583	DNA-binding transcription factor activity
K562_RS08060	COG2224	Isocitrate lyase
K562_RS08065	COG0513	Belongs to the DEAD box helicase family
K562_RS08075	COG1214	PFAM Peptidase M22, glycoprotease
K562_RS08085	COG1573	uracil-dna glycosylase
K562_RS08095	COG0351	phosphomethylpyrimidine kinase
K562_RS08100	COG0477	Major facilitator Superfamily
K562_RS08120	COG0488	(ABC) transporter
K562_RS08125	COG0386	Belongs to the glutathione peroxidase family
K562_RS08135	COG2890	protein-(glutamine-N5) methyltransferase activity
K562_RS08140	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K562_RS08145	COG1393	Belongs to the ArsC family
K562_RS08175	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
K562_RS08180	COG0242	peptide deformylase activity
K562_RS08185	COG1187	pseudouridine synthase activity
K562_RS08195	COG0024	Methionine aminopeptidase
K562_RS08200	COG0052	Belongs to the universal ribosomal protein uS2 family
K562_RS08205	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
K562_RS08215	COG0233	cytoplasmic translational termination
K562_RS08220	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K562_RS08235	COG0750	zinc metalloprotease
K562_RS08250	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K562_RS08260	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K562_RS08265	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
K562_RS08270	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
K562_RS08275	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K562_RS08280	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
K562_RS08295	COG0330	HflC and HflK could
K562_RS08310	COG2914	Belongs to the UPF0125 (RnfH) family
K562_RS08315	COG0697	spore germination
K562_RS08350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
K562_RS08350	COG0519	Catalyzes the synthesis of GMP from XMP
K562_RS08355	COG2176	DNA-directed DNA polymerase activity
K562_RS08365	COG0456	acetyltransferase
K562_RS08395	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K562_RS08410	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K562_RS08430	COG0590	tRNA wobble adenosine to inosine editing
K562_RS08435	COG1619	proteins homologs of microcin C7 resistance protein MccF
K562_RS08445	COG1953	Uracil, thiamine, allantoin
K562_RS08460	COG3195	allantoin biosynthetic process
K562_RS08460	COG3648	Uricase
K562_RS08465	COG4266	Belongs to the allantoicase family
K562_RS08480	COG0251	oxidation-reduction process
K562_RS08490	COG0583	DNA-binding transcription factor activity
K562_RS08505	COG2351	hydroxyisourate hydrolase activity
K562_RS08520	COG3360	Dodecin
K562_RS08535	COG1970	mechanosensitive ion channel activity
K562_RS08565	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
K562_RS08570	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
K562_RS08575	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
K562_RS08585	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K562_RS08665	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K562_RS08675	COG1929	Belongs to the glycerate kinase type-1 family
K562_RS08680	COG0544	peptidyl-prolyl cis-trans isomerase activity
K562_RS08695	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
K562_RS08720	COG4181	ATPase activity
K562_RS08725	COG0166	Belongs to the GPI family
K562_RS08735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K562_RS08740	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
K562_RS08740	COG0047	phosphoribosylformylglycinamidine synthase activity
K562_RS08750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K562_RS08760	COG2917	probably involved in intracellular septation
K562_RS08765	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K562_RS08770	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
K562_RS08775	COG0318	PFAM AMP-dependent synthetase and ligase
K562_RS08785	COG1335	isochorismatase
K562_RS08790	COG0183	Belongs to the thiolase family
K562_RS08845	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
K562_RS08850	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
K562_RS08860	COG0084	hydrolase, TatD family'
K562_RS08885	COG0438	transferase activity, transferring glycosyl groups
K562_RS08905	COG0252	asparaginase activity
K562_RS08910	COG1652	LysM domain
K562_RS08915	COG2084	Dehydrogenase
K562_RS08920	COG3622	Belongs to the hyi family
K562_RS08925	COG3960	tartronate-semialdehyde synthase activity
K562_RS08930	COG0583	DNA-binding transcription factor activity
K562_RS08950	COG2965	DNA replication, synthesis of RNA primer
K562_RS08965	COG0305	Participates in initiation and elongation during chromosome replication
K562_RS08975	COG0306	phosphate transporter
K562_RS08980	COG0791	NLP P60 protein
K562_RS08985	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
K562_RS08990	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K562_RS08995	COG0726	polysaccharide deacetylase
K562_RS09000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K562_RS09000	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
K562_RS09010	COG0463	Glycosyl transferase, family 2
K562_RS09015	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
K562_RS09020	COG2076	Multidrug Resistance protein
K562_RS09025	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
K562_RS09035	COG0436	Aminotransferase
K562_RS09055	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
K562_RS09060	COG0314	molybdopterin synthase activity
K562_RS09065	COG2346	COG2346, Truncated hemoglobins
K562_RS09070	COG1959	2 iron, 2 sulfur cluster binding
K562_RS09075	COG0542	response to heat
K562_RS09100	COG3284	Transcriptional regulator
K562_RS09105	COG3199	ATP-NAD kinase
K562_RS09115	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
K562_RS09120	COG0022	dehydrogenase e1 component
K562_RS09130	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
K562_RS09135	COG0534	Mate efflux family protein
K562_RS09145	COG0254	rRNA binding
K562_RS09150	COG3228	Belongs to the MtfA family
K562_RS09155	COG0477	Major facilitator Superfamily
K562_RS09165	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
K562_RS09180	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
K562_RS09195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K562_RS09235	COG0670	Belongs to the BI1 family
K562_RS09245	COG0820	rRNA (adenine-C2-)-methyltransferase activity
K562_RS09255	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
K562_RS09270	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K562_RS09275	COG1160	GTP binding
K562_RS09285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
K562_RS09290	COG0330	HflC and HflK could
K562_RS09295	COG0330	HflC and HflK could
K562_RS09305	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
K562_RS09315	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
K562_RS09325	COG2183	response to ionizing radiation
K562_RS09340	COG1199	ATP-dependent helicase activity
K562_RS09350	COG0564	pseudouridine synthase activity
K562_RS09360	COG3243	poly(R)-hydroxyalkanoic acid synthase
K562_RS09365	COG0183	Belongs to the thiolase family
K562_RS09370	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS09385	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
K562_RS09400	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K562_RS09415	COG0626	cystathionine gamma-synthase activity
K562_RS09420	COG0560	Phosphoserine phosphatase
K562_RS09425	COG0583	DNA-binding transcription factor activity
K562_RS09445	COG0390	transport system, permease component
K562_RS09450	COG1122	ATPase activity
K562_RS09455	COG2982	Protein involved in outer membrane biogenesis
K562_RS09465	COG0488	(ABC) transporter
K562_RS09480	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K562_RS09490	COG1819	glycosyl
K562_RS09505	COG0726	polysaccharide deacetylase
K562_RS09530	COG2070	2-Nitropropane dioxygenase
K562_RS09535	COG3047	cAMP biosynthetic process
K562_RS09540	COG3188	usher protein
K562_RS09545	COG3121	Chaperone
K562_RS09550	COG3539	Fimbrial protein
K562_RS09560	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K562_RS09565	COG3842	ATPase activity
K562_RS09570	COG1176	ABC-type spermidine putrescine transport system, permease component I
K562_RS09575	COG1177	transmembrane transport
K562_RS09580	COG0730	response to heat
K562_RS09580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K562_RS09605	COG3655	Transcriptional regulator
K562_RS09625	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K562_RS09630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K562_RS09640	COG0038	chloride channel
K562_RS09645	COG2855	membrane
K562_RS09660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K562_RS09675	COG1609	Transcriptional regulator
K562_RS09720	COG0598	Magnesium transport protein CorA
K562_RS09760	COG1396	sequence-specific DNA binding
K562_RS09770	COG4771	TonB-dependent receptor
K562_RS09775	COG4166	transmembrane transport
K562_RS09780	COG4174	ABC transporter (Permease)
K562_RS09785	COG4239	(ABC) transporter, permease
K562_RS09790	COG4172	Belongs to the ABC transporter superfamily
K562_RS09795	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K562_RS09805	COG4771	TonB-dependent receptor
K562_RS09820	COG4638	Rieske (2fe-2S)
K562_RS09855	COG0477	Major facilitator Superfamily
K562_RS09860	COG1764	response to oxidative stress
K562_RS09885	COG1846	Transcriptional regulator
K562_RS09895	COG2070	2-Nitropropane dioxygenase
K562_RS09920	COG2271	Major facilitator Superfamily
K562_RS09925	COG0583	DNA-binding transcription factor activity
K562_RS09940	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K562_RS09945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K562_RS09950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K562_RS09970	COG1176	ABC-type spermidine putrescine transport system, permease component I
K562_RS09975	COG3842	ATPase activity
K562_RS09995	COG3246	L-lysine catabolic process to acetate
K562_RS10000	COG2175	clavaminate synthase activity
K562_RS10015	COG2909	trisaccharide binding
K562_RS10025	COG0625	glutathione transferase activity
K562_RS10030	COG1846	Transcriptional regulator
K562_RS10035	COG2807	transmembrane transport
K562_RS10045	COG2099	Precorrin-6x reductase
K562_RS10050	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
K562_RS10080	COG3979	chitinase
K562_RS10095	COG2851	Citrate transporter
K562_RS10110	COG0494	nUDIX hydrolase
K562_RS10125	COG1671	Belongs to the UPF0178 family
K562_RS10180	COG3609	addiction module antidote protein, CC2985 family
K562_RS10185	COG1473	amidohydrolase
K562_RS10200	COG4774	siderophore transport
K562_RS10205	COG3486	L-lysine 6-monooxygenase (NADPH) activity
K562_RS10245	COG1120	ATPase activity
K562_RS10250	COG2175	clavaminate synthase activity
K562_RS10305	COG3121	Chaperone
K562_RS10310	COG3188	usher protein
K562_RS10330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K562_RS10340	COG1309	transcriptional regulator
K562_RS10345	COG0739	heme binding
K562_RS10350	COG0765	amino acid transport
K562_RS10355	COG0765	amino acid transport
K562_RS10360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K562_RS10365	COG0477	Major facilitator Superfamily
K562_RS10370	COG2719	SpoVR family
K562_RS10375	COG2718	Belongs to the UPF0229 family
K562_RS10380	COG2766	serine protein kinase
K562_RS10385	COG0840	transmembrane signaling receptor activity
K562_RS10390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K562_RS10395	COG1609	Transcriptional regulator
K562_RS10400	COG1172	Belongs to the binding-protein-dependent transport system permease family
K562_RS10405	COG1129	ABC transporter
K562_RS10410	COG1879	ABC-type sugar transport system periplasmic component
K562_RS10415	COG0583	DNA-binding transcription factor activity
K562_RS10420	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K562_RS10425	COG4208	sulfate ABC transporter
K562_RS10430	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
K562_RS10435	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
K562_RS10440	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
K562_RS10475	COG0701	Predicted permease
K562_RS10480	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
K562_RS10485	COG0583	DNA-binding transcription factor activity
K562_RS10500	COG0667	Aldo Keto reductase
K562_RS10570	COG0456	acetyltransferase
K562_RS10585	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K562_RS10610	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K562_RS10635	COG4702	Belongs to the UPF0303 family
K562_RS10650	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
K562_RS10655	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
K562_RS10660	COG0167	dihydroorotate dehydrogenase activity
K562_RS10665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K562_RS10670	COG0765	amino acid transport
K562_RS10765	COG2842	Transposition protein
K562_RS10795	COG0776	regulation of translation
K562_RS10870	COG4386	tail sheath protein
K562_RS10940	COG1802	Transcriptional regulator
K562_RS10945	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
K562_RS10950	COG3023	N-Acetylmuramoyl-L-alanine amidase
K562_RS10955	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
K562_RS10960	COG0557	exoribonuclease II activity
K562_RS10970	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K562_RS10995	COG1172	Belongs to the binding-protein-dependent transport system permease family
K562_RS11000	COG1879	ABC-type sugar transport system periplasmic component
K562_RS11025	COG2814	Major facilitator Superfamily
K562_RS11035	COG0318	PFAM AMP-dependent synthetase and ligase
K562_RS11100	COG4964	Belongs to the GSP D family
K562_RS11150	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
K562_RS11155	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
K562_RS11160	COG0508	dehydrogenase complex catalyzes the overall conversion of
K562_RS11165	COG0567	Dehydrogenase, E1 component
K562_RS11170	COG1217	gtp-binding protein TYPA
K562_RS11175	COG1846	Transcriptional regulator
K562_RS11185	COG1566	PFAM secretion protein HlyD family protein
K562_RS11190	COG2814	Major facilitator Superfamily
K562_RS11200	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
K562_RS11205	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
K562_RS11210	COG0195	Participates in both transcription termination and antitermination
K562_RS11210	COG2251	uridine kinase activity
K562_RS11215	COG0779	Required for maturation of 30S ribosomal subunits
K562_RS11225	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
K562_RS11230	COG0436	Aminotransferase
K562_RS11235	COG0583	DNA-binding transcription factor activity
K562_RS11275	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
K562_RS11290	COG2365	Tyrosine phosphatase family
K562_RS11310	COG0776	regulation of translation
K562_RS11320	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
K562_RS11335	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
K562_RS11340	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
K562_RS11350	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K562_RS11355	COG0251	oxidation-reduction process
K562_RS11365	COG0583	DNA-binding transcription factor activity
K562_RS11380	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS11405	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS11415	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
K562_RS11420	COG0477	Major facilitator Superfamily
K562_RS11435	COG1295	ribonuclease BN
K562_RS11450	COG0277	FAD linked oxidase domain protein
K562_RS11465	COG0583	DNA-binding transcription factor activity
K562_RS11490	COG0840	transmembrane signaling receptor activity
K562_RS11495	COG2223	nitrite transmembrane transporter activity
K562_RS11500	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K562_RS11505	COG0210	DNA helicase
K562_RS11510	COG0525	valine-tRNA ligase activity
K562_RS11515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K562_RS11525	COG5002	protein histidine kinase activity
K562_RS11535	COG0745	RESPONSE REGULATOR receiver
K562_RS11545	COG0425	Belongs to the sulfur carrier protein TusA family
K562_RS11560	COG1737	Transcriptional regulator
K562_RS11565	COG0673	inositol 2-dehydrogenase activity
K562_RS11580	COG1082	Xylose isomerase domain protein TIM barrel
K562_RS11585	COG1172	Belongs to the binding-protein-dependent transport system permease family
K562_RS11600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K562_RS11605	COG3962	Belongs to the TPP enzyme family
K562_RS11615	COG3718	enzyme involved in inositol metabolism
K562_RS11620	COG4702	Belongs to the UPF0303 family
K562_RS11625	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS11650	COG0824	Thioesterase
K562_RS11655	COG2816	NAD+ diphosphatase activity
K562_RS11660	COG0477	Major facilitator Superfamily
K562_RS11670	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
K562_RS11675	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K562_RS11690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
K562_RS11695	COG0494	nUDIX hydrolase
K562_RS11705	COG1858	cytochrome C peroxidase
K562_RS11745	COG0583	DNA-binding transcription factor activity
K562_RS11760	COG0025	NhaP-type Na H and K H
K562_RS11770	COG1741	Belongs to the pirin family
K562_RS11780	COG2194	sulfuric ester hydrolase activity
K562_RS11810	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
K562_RS11815	COG1215	transferase activity, transferring glycosyl groups
K562_RS11825	COG2453	phosphatase
K562_RS11825	COG0671	phosphoesterase, PA-phosphatase related
K562_RS11830	COG2267	carboxylic ester hydrolase activity
K562_RS11835	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
K562_RS11850	COG4589	Belongs to the CDS family
K562_RS11860	COG2197	response regulator
K562_RS11880	COG2851	Citrate transporter
K562_RS11885	COG0583	DNA-binding transcription factor activity
K562_RS11890	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K562_RS11900	COG0583	DNA-binding transcription factor activity
K562_RS11910	COG4774	siderophore transport
K562_RS11915	COG3712	iron ion homeostasis
K562_RS11920	COG1595	DNA-templated transcription, initiation
K562_RS11925	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS12015	COG0745	RESPONSE REGULATOR receiver
K562_RS12020	COG2205	protein histidine kinase activity
K562_RS12025	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K562_RS12035	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
K562_RS12040	COG4774	siderophore transport
K562_RS12055	COG3485	protocatechuate 3,4-dioxygenase
K562_RS12070	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K562_RS12085	COG0446	pyridine nucleotide-disulphide oxidoreductase
K562_RS12085	COG1902	pentaerythritol trinitrate reductase activity
K562_RS12090	COG1695	Transcriptional regulator
K562_RS12100	COG1960	acyl-CoA dehydrogenase activity
K562_RS12105	COG0235	Class ii aldolase
K562_RS12130	COG1215	transferase activity, transferring glycosyl groups
K562_RS12160	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
K562_RS12175	COG3707	response regulator
K562_RS12180	COG0582	viral genome integration into host DNA
K562_RS12195	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
K562_RS12280	COG4942	peptidase
K562_RS12285	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K562_RS12295	COG0534	Mate efflux family protein
K562_RS12345	COG0745	RESPONSE REGULATOR receiver
K562_RS12360	COG0581	inorganic phosphate transmembrane transporter activity
K562_RS12365	COG0573	inorganic phosphate transmembrane transporter activity
K562_RS12370	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
K562_RS12375	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
K562_RS12385	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
K562_RS12395	COG1534	Rna-binding protein
K562_RS12405	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K562_RS12410	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
K562_RS12420	COG0505	Belongs to the CarA family
K562_RS12425	COG2223	nitrite transmembrane transporter activity
K562_RS12430	COG0741	lytic transglycosylase activity
K562_RS12430	COG1388	LysM domain
K562_RS12435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K562_RS12440	COG2226	methyltransferase
K562_RS12445	COG0328	RNA-DNA hybrid ribonuclease activity
K562_RS12450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
K562_RS12495	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
K562_RS12515	COG3052	prosthetic group binding
K562_RS12535	COG0583	DNA-binding transcription factor activity
K562_RS12545	COG1250	3-hydroxyacyl-CoA dehydrogenase
K562_RS12565	COG1253	flavin adenine dinucleotide binding
K562_RS12570	COG0583	DNA-binding transcription factor activity
K562_RS12585	COG0583	DNA-binding transcription factor activity
K562_RS12590	COG2814	Major facilitator Superfamily
K562_RS12605	COG0477	Major facilitator Superfamily
K562_RS12610	COG0583	DNA-binding transcription factor activity
K562_RS12620	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
K562_RS12625	COG0456	acetyltransferase
K562_RS12630	COG0010	Belongs to the arginase family
K562_RS12640	COG0702	epimerase
K562_RS12655	COG0022	dehydrogenase e1 component
K562_RS12665	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K562_RS12670	COG0583	DNA-binding transcription factor activity
K562_RS12675	COG1902	pentaerythritol trinitrate reductase activity
K562_RS12680	COG2259	Doxx family
K562_RS12690	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS12695	COG0210	DNA helicase
K562_RS12695	COG0210	DNA helicase
K562_RS12720	COG5377	YqaJ viral recombinase family
K562_RS12755	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K562_RS12755	COG2755	lipolytic protein G-D-S-L family
K562_RS12780	COG0673	inositol 2-dehydrogenase activity
K562_RS12795	COG1012	belongs to the aldehyde dehydrogenase family
K562_RS12800	COG1309	transcriptional regulator
K562_RS12805	COG1929	Belongs to the glycerate kinase type-1 family
K562_RS12840	COG2963	transposase activity
K562_RS12845	COG3436	PFAM IS66 Orf2 family protein
K562_RS12850	COG4372	Transposase
K562_RS12890	COG4372	Transposase
K562_RS12920	COG1021	2,3-dihydroxybenzoate-AMP ligase
K562_RS12935	COG2814	Major facilitator Superfamily
K562_RS12940	COG3473	Maleate cis-trans isomerase
K562_RS12945	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS12960	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS12985	COG2207	Transcriptional regulator
K562_RS13075	COG4983	Phage plasmid primase, P4 family domain protein
K562_RS13095	COG0582	viral genome integration into host DNA
K562_RS13100	COG1609	Transcriptional regulator
K562_RS13105	COG1840	ABC-type Fe3 transport system, periplasmic component
K562_RS13115	COG1177	transmembrane transport
K562_RS13120	COG3842	ATPase activity
K562_RS13125	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K562_RS13130	COG2814	Major facilitator Superfamily
K562_RS13135	COG0697	spore germination
K562_RS13150	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K562_RS13155	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
K562_RS13165	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
K562_RS13190	COG2200	EAL domain
K562_RS13200	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K562_RS13205	COG1074	ATP-dependent DNA helicase activity
K562_RS13210	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
K562_RS13215	COG1289	transmembrane transporter activity
K562_RS13230	COG1840	ABC-type Fe3 transport system, periplasmic component
K562_RS13235	COG1178	ABC-type Fe3 transport system permease component
K562_RS13240	COG3842	ATPase activity
K562_RS13245	COG1522	sequence-specific DNA binding
K562_RS13255	COG1959	2 iron, 2 sulfur cluster binding
K562_RS13270	COG0004	ammonium transporteR
K562_RS13285	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K562_RS13295	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K562_RS13310	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS13365	COG2988	succinylglutamate desuccinylase activity
K562_RS13370	COG3724	N-succinylarginine dihydrolase activity
K562_RS13375	COG1012	belongs to the aldehyde dehydrogenase family
K562_RS13390	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
K562_RS13425	COG3394	polysaccharide catabolic process
K562_RS13430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
K562_RS13440	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K562_RS13455	COG3511	phospholipase C
K562_RS13485	COG0438	transferase activity, transferring glycosyl groups
K562_RS13490	COG1132	(ABC) transporter
K562_RS13510	COG1999	signal sequence binding
K562_RS13525	COG2153	protein acetylation
K562_RS13545	COG1956	GAF domain-containing protein
K562_RS13550	COG0024	Methionine aminopeptidase
K562_RS13570	COG0596	Alpha beta hydrolase
K562_RS13575	COG2203	Gaf domain
K562_RS13575	COG3706	GGDEF domain
K562_RS13575	COG4251	negative regulation of phosphorylation
K562_RS13575	COG5001	Diguanylate cyclase
K562_RS13615	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
K562_RS13620	COG2204	response regulator
K562_RS13625	COG1472	Belongs to the glycosyl hydrolase 3 family
K562_RS13645	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
K562_RS13650	COG0571	ribonuclease III activity
K562_RS13655	COG0681	Belongs to the peptidase S26 family
K562_RS13670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K562_RS13685	COG1595	DNA-templated transcription, initiation
K562_RS13695	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
K562_RS13730	COG1399	metal-binding, possibly nucleic acid-binding protein
K562_RS13745	COG0616	signal peptide processing
K562_RS13755	COG0546	phosphoglycolate phosphatase activity
K562_RS13765	COG1530	ribonuclease E activity
K562_RS13770	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K562_RS13780	COG0303	'Molybdopterin
K562_RS13820	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
K562_RS13835	COG3045	CreA protein
K562_RS13865	COG2501	S4 domain
K562_RS13875	COG0114	fumarate hydratase activity
K562_RS13900	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
K562_RS13905	COG2204	response regulator
K562_RS13920	COG0312	modulator of DNA gyrase
K562_RS13925	COG3028	Belongs to the UPF0307 family
K562_RS13930	COG0521	Mo-molybdopterin cofactor biosynthetic process
K562_RS13940	COG0501	Belongs to the peptidase M48B family
K562_RS13960	COG0494	nUDIX hydrolase
K562_RS13970	COG0336	Belongs to the RNA methyltransferase TrmD family
K562_RS14005	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K562_RS14025	COG2011	ABC-type metal ion transport system permease component
K562_RS14035	COG2267	carboxylic ester hydrolase activity
K562_RS14040	COG0123	including yeast histone deacetylase and acetoin utilization protein
K562_RS14045	COG2951	lytic endotransglycosylase activity
K562_RS14060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K562_RS14065	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
K562_RS14075	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
K562_RS14085	COG0776	regulation of translation
K562_RS14095	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
K562_RS14100	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
K562_RS14105	COG0287	Prephenate dehydrogenase
K562_RS14115	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
K562_RS14135	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K562_RS14140	COG0546	phosphoglycolate phosphatase activity
K562_RS14150	COG0582	viral genome integration into host DNA
K562_RS14260	COG1910	domain protein
K562_RS14275	COG3383	formate dehydrogenase (NAD+) activity
K562_RS14310	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
K562_RS14320	COG0154	amidase activity
K562_RS14335	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K562_RS14345	COG0402	S-adenosylhomocysteine deaminase activity
K562_RS14350	COG2119	membrane
K562_RS14360	COG0308	aminopeptidase N
K562_RS14365	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
K562_RS14405	COG4772	TonB-dependent receptor
K562_RS14430	COG1278	Cold shock
K562_RS14440	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS14465	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
K562_RS14480	COG1561	YicC-like family, N-terminal region
K562_RS14485	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
K562_RS14490	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
K562_RS14495	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K562_RS14520	COG0477	Major facilitator Superfamily
K562_RS14545	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
K562_RS14550	COG2894	cell division
K562_RS14555	COG0850	regulation of cytokinetic process
K562_RS14575	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K562_RS14585	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
K562_RS14590	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
K562_RS14595	COG1674	ftsk spoiiie
K562_RS14600	COG0492	ferredoxin-NADP+ reductase activity
K562_RS14605	COG1193	negative regulation of DNA recombination
K562_RS14610	COG2860	membrane
K562_RS14615	COG3842	ATPase activity
K562_RS14620	COG0395	ABC-type sugar transport system, permease component
K562_RS14625	COG1175	transmembrane transport
K562_RS14635	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K562_RS14640	COG0363	glucosamine-6-phosphate deaminase activity
K562_RS14655	COG2814	Major facilitator Superfamily
K562_RS14665	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K562_RS14670	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K562_RS14670	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
K562_RS14700	COG0436	Aminotransferase
K562_RS14735	COG0762	integral membrane protein
K562_RS14745	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
K562_RS14750	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
K562_RS14760	COG0494	nUDIX hydrolase
K562_RS14770	COG1024	Enoyl-CoA hydratase
K562_RS14775	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K562_RS14780	COG2814	Major facilitator Superfamily
K562_RS14785	COG0583	DNA-binding transcription factor activity
K562_RS14795	COG4948	Mandelate Racemase Muconate Lactonizing
K562_RS14860	COG0590	tRNA wobble adenosine to inosine editing
K562_RS14870	COG2351	hydroxyisourate hydrolase activity
K562_RS14875	COG2271	Major facilitator Superfamily
K562_RS14910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
K562_RS14920	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
K562_RS14935	COG0559	Belongs to the binding-protein-dependent transport system permease family
K562_RS14945	COG1129	ABC transporter
K562_RS14955	COG0829	nickel cation binding
K562_RS14960	COG0831	urea catabolic process
K562_RS14965	COG0832	Belongs to the urease beta subunit family
K562_RS14970	COG0804	urea catabolic process
K562_RS14980	COG0830	nickel cation binding
K562_RS15020	COG0438	transferase activity, transferring glycosyl groups
K562_RS15025	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K562_RS15040	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
K562_RS15060	COG1215	transferase activity, transferring glycosyl groups
K562_RS15065	COG0438	transferase activity, transferring glycosyl groups
K562_RS15070	COG1215	transferase activity, transferring glycosyl groups
K562_RS15130	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
K562_RS15140	COG1678	Uncharacterized ACR, COG1678
K562_RS15150	COG1773	rubredoxin
K562_RS15160	COG0459	protein refolding
K562_RS15165	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K562_RS15230	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
K562_RS15240	COG0730	response to heat
K562_RS15300	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K562_RS15320	COG4977	sequence-specific DNA binding
K562_RS15325	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K562_RS15330	COG0583	DNA-binding transcription factor activity
K562_RS15335	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K562_RS15340	COG0778	Nitroreductase
K562_RS15345	COG2814	Major facilitator Superfamily
K562_RS15360	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
K562_RS15365	COG2814	Major facilitator Superfamily
K562_RS15395	COG1960	acyl-CoA dehydrogenase activity
K562_RS15400	COG0450	alkyl hydroperoxide reductase
K562_RS15425	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
K562_RS15435	COG4221	oxidoreductase activity
K562_RS15440	COG0824	Thioesterase
K562_RS15460	COG0823	Involved in the tonB-independent uptake of proteins
K562_RS15520	COG4682	membrane
K562_RS15530	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K562_RS15540	COG0529	Catalyzes the synthesis of activated sulfate
K562_RS15550	COG0156	8-amino-7-oxononanoate synthase activity
K562_RS15555	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K562_RS15560	COG0604	alcohol dehydrogenase
K562_RS15560	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS15560	COG3321	synthase
K562_RS15565	COG1368	sulfuric ester hydrolase activity
K562_RS15570	COG0300	oxidoreductase activity
K562_RS15645	COG1215	transferase activity, transferring glycosyl groups
K562_RS15665	COG4372	Transposase
K562_RS15670	COG1216	Glycosyl transferase, family 2
K562_RS15725	COG3328	transposase activity
K562_RS15745	COG0586	Pfam SNARE associated Golgi protein
K562_RS15750	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
K562_RS15755	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
K562_RS15775	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
K562_RS15780	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
K562_RS15790	COG0617	tRNA 3'-terminal CCA addition
K562_RS15795	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
K562_RS15810	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
K562_RS15810	COG0512	Glutamine amidotransferase of anthranilate synthase
K562_RS15820	COG0443	Heat shock 70 kDa protein
K562_RS15830	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
K562_RS15850	COG1420	regulation of RNA biosynthetic process
K562_RS15855	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
K562_RS15860	COG0497	DNA recombination
K562_RS15865	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
K562_RS15875	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K562_RS15880	COG0312	modulator of DNA gyrase
K562_RS15890	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K562_RS15905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
K562_RS15905	COG1017	nitric oxide dioxygenase activity
K562_RS15910	COG2096	Adenosyltransferase
K562_RS15915	COG0277	FAD linked oxidase domain protein
K562_RS15920	COG0277	FAD linked oxidase domain protein
K562_RS15925	COG0277	FAD linked oxidase domain protein
K562_RS15930	COG0247	lactate metabolic process
K562_RS15950	COG0783	Belongs to the Dps family
K562_RS15960	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K562_RS15970	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
K562_RS15975	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
K562_RS15980	COG0343	queuine tRNA-ribosyltransferase activity
K562_RS15985	COG1862	Preprotein translocase
K562_RS15990	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K562_RS15995	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
K562_RS16000	COG0793	Belongs to the peptidase S41A family
K562_RS16015	COG2353	YceI-like domain
K562_RS16030	COG2995	paraquat-inducible protein a
K562_RS16035	COG3008	intermembrane lipid transfer
K562_RS16035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
K562_RS16060	COG0640	Transcriptional regulator
K562_RS16105	COG0482	sulfurtransferase activity
K562_RS16110	COG0069	glutamate synthase activity
K562_RS16115	COG0625	glutathione transferase activity
K562_RS16120	COG0006	proline dipeptidase activity
K562_RS16125	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K562_RS16130	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
K562_RS16135	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
K562_RS16140	COG0138	bifunctional purine biosynthesis protein purh
K562_RS16150	COG0632	four-way junction helicase activity
K562_RS16155	COG2255	four-way junction helicase activity
K562_RS16170	COG0588	phosphoglycerate mutase activity
K562_RS16175	COG1490	D-aminoacyl-tRNA deacylase activity
K562_RS16185	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
K562_RS16200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
K562_RS16225	COG0418	dihydroorotase activity
K562_RS16230	COG0121	glutamine amidotransferase
K562_RS16240	COG1126	abc transporter atp-binding protein
K562_RS16245	COG0765	amino acid transport
K562_RS16250	COG0765	amino acid transport
K562_RS16260	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
K562_RS16265	COG0583	DNA-binding transcription factor activity
K562_RS16275	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
K562_RS16285	COG3265	gluconokinase activity
K562_RS16295	COG0800	Aldolase
K562_RS16310	COG1981	membrane
K562_RS16315	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
K562_RS16320	COG1466	dna polymerase III delta subunit
K562_RS16325	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
K562_RS16330	COG0495	leucyl-tRNA aminoacylation
K562_RS16345	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
K562_RS16350	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
K562_RS16355	COG0735	belongs to the Fur family
K562_RS16360	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
K562_RS16365	COG4266	Belongs to the allantoicase family
K562_RS16370	COG1301	dicarboxylic acid transport
K562_RS16380	COG0583	DNA-binding transcription factor activity
K562_RS16385	COG2814	Major facilitator Superfamily
K562_RS16390	COG1063	alcohol dehydrogenase
K562_RS16395	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS16400	COG0583	DNA-binding transcription factor activity
K562_RS16405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
K562_RS16410	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
K562_RS16415	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K562_RS16425	COG1385	rRNA (uridine-N3-)-methyltransferase activity
K562_RS16435	COG4290	ribonuclease
K562_RS16450	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
K562_RS16455	COG1546	Belongs to the CinA family
K562_RS16465	COG0284	orotidine-5'-phosphate decarboxylase activity
K562_RS16495	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS16500	COG0800	Aldolase
K562_RS16505	COG3734	2-keto-3-deoxy-galactonokinase
K562_RS16510	COG1414	Transcriptional regulator
K562_RS16530	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K562_RS16535	COG0557	exoribonuclease II activity
K562_RS16540	COG3150	esterase
K562_RS16545	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K562_RS16555	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
K562_RS16560	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K562_RS16565	COG0511	ligase activity, forming carbon-carbon bonds
K562_RS16570	COG0439	Biotin carboxylase
K562_RS16575	COG2264	protein methyltransferase activity
K562_RS16585	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
K562_RS16590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K562_RS16635	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
K562_RS16640	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
K562_RS16645	COG2095	MarC family integral membrane protein
K562_RS16650	COG0442	prolyl-tRNA aminoacylation
K562_RS16655	COG0494	nUDIX hydrolase
K562_RS16670	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
K562_RS16685	COG0142	geranyltranstransferase activity
K562_RS16695	COG4536	flavin adenine dinucleotide binding
K562_RS16710	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
K562_RS16720	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
K562_RS16725	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
K562_RS16730	COG0494	nUDIX hydrolase
K562_RS16745	COG0653	protein targeting
K562_RS16755	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
K562_RS16760	COG0678	peroxiredoxin activity
K562_RS16775	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
K562_RS16780	COG1181	Belongs to the D-alanine--D-alanine ligase family
K562_RS16785	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
K562_RS16790	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
K562_RS16810	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
K562_RS16815	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
K562_RS16825	COG3116	cell division
K562_RS16830	COG0275	rRNA processing
K562_RS16835	COG2001	Belongs to the MraZ family
K562_RS16840	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
K562_RS16845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS16855	COG0318	PFAM AMP-dependent synthetase and ligase
K562_RS16860	COG0243	molybdopterin cofactor binding
K562_RS16880	COG3038	cytochrome b561
K562_RS16885	COG0753	catalase activity
K562_RS16940	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K562_RS16945	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
K562_RS16975	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS16990	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K562_RS17010	COG1987	bacterial-type flagellum assembly
K562_RS17015	COG1338	Plays a role in the flagellum-specific transport system
K562_RS17025	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
K562_RS17040	COG1346	cytolysis
K562_RS17045	COG1380	Effector of murein hydrolase LrgA
K562_RS17050	COG0583	DNA-binding transcription factor activity
K562_RS17060	COG2814	Major facilitator Superfamily
K562_RS17065	COG1846	Transcriptional regulator
K562_RS17110	COG2165	general secretion pathway protein
K562_RS17145	COG0523	cobalamin synthesis protein
K562_RS17160	COG1595	DNA-templated transcription, initiation
K562_RS17175	COG1192	Involved in chromosome partitioning
K562_RS17205	COG1396	sequence-specific DNA binding
K562_RS17215	COG1063	alcohol dehydrogenase
K562_RS17230	COG1309	transcriptional regulator
K562_RS17240	COG0473	3-isopropylmalate dehydrogenase activity
K562_RS17245	COG0583	DNA-binding transcription factor activity
K562_RS17250	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
K562_RS17270	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS17275	COG4689	acetoacetate decarboxylase
K562_RS17280	COG0671	phosphoesterase, PA-phosphatase related
K562_RS17295	COG1695	Transcriptional regulator
K562_RS17335	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS17340	COG1063	alcohol dehydrogenase
K562_RS17410	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K562_RS17415	COG0589	response to stress
K562_RS17430	COG1045	serine acetyltransferase
K562_RS17460	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
K562_RS17470	COG0596	Alpha beta hydrolase
K562_RS17475	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K562_RS17480	COG2814	Major facilitator Superfamily
K562_RS17500	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS17505	COG0477	Major facilitator Superfamily
K562_RS17520	COG4948	Mandelate Racemase Muconate Lactonizing
K562_RS17550	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K562_RS17560	COG0179	Fumarylacetoacetate (FAA) hydrolase
K562_RS17565	COG0318	PFAM AMP-dependent synthetase and ligase
K562_RS17570	COG3047	cAMP biosynthetic process
K562_RS17595	COG1301	dicarboxylic acid transport
K562_RS17640	COG1070	Carbohydrate kinase
K562_RS17655	COG1063	alcohol dehydrogenase
K562_RS17660	COG0395	ABC-type sugar transport system, permease component
K562_RS17695	COG4948	Mandelate Racemase Muconate Lactonizing
K562_RS17710	COG2271	Major facilitator Superfamily
K562_RS17720	COG2205	protein histidine kinase activity
K562_RS17725	COG0745	RESPONSE REGULATOR receiver
K562_RS17770	COG2409	Drug exporters of the RND superfamily
K562_RS17800	COG0318	PFAM AMP-dependent synthetase and ligase
K562_RS17805	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
K562_RS17810	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K562_RS17815	COG1309	transcriptional regulator
K562_RS17820	COG1960	acyl-CoA dehydrogenase activity
K562_RS17830	COG0318	PFAM AMP-dependent synthetase and ligase
K562_RS17845	COG0604	alcohol dehydrogenase
K562_RS17845	COG3321	synthase
K562_RS17880	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS17885	COG1960	acyl-CoA dehydrogenase activity
K562_RS17905	COG0417	DNA replication proofreading
K562_RS17920	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K562_RS17945	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
K562_RS17950	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS17955	COG1414	Transcriptional regulator
K562_RS17965	COG1716	ATPase activity
K562_RS17965	COG5001	Diguanylate cyclase
K562_RS18005	COG1252	NADH dehydrogenase
K562_RS18010	COG0583	DNA-binding transcription factor activity
K562_RS18030	COG3135	benzoate transporter
K562_RS18045	COG0513	Belongs to the DEAD box helicase family
K562_RS18065	COG1522	sequence-specific DNA binding
K562_RS18075	COG0683	leucine binding
K562_RS18080	COG0668	transmembrane transport
K562_RS18085	COG0739	heme binding
K562_RS18090	COG0753	catalase activity
K562_RS18095	COG3038	cytochrome b561
K562_RS18120	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K562_RS18125	COG2197	response regulator
K562_RS18135	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K562_RS18140	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K562_RS18170	COG0583	DNA-binding transcription factor activity
K562_RS18225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K562_RS18230	COG1596	polysaccharide export
K562_RS18235	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K562_RS18260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
K562_RS18275	COG0784	Response regulator, receiver
K562_RS18275	COG2205	protein histidine kinase activity
K562_RS18295	COG2197	response regulator
K562_RS18300	COG2197	response regulator
K562_RS18310	COG5295	Hep Hag repeat protein
K562_RS18330	COG2205	protein histidine kinase activity
K562_RS18330	COG0784	Response regulator, receiver
K562_RS18335	COG0745	RESPONSE REGULATOR receiver
K562_RS18345	COG4566	intracellular signal transduction
K562_RS18365	COG0640	Transcriptional regulator
K562_RS18375	COG0798	PFAM Bile acid sodium symporter
K562_RS18380	COG0431	NADPH-dependent FMN reductase
K562_RS18390	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K562_RS18395	COG2916	Histone family protein nucleoid-structuring protein H-NS
K562_RS18440	COG2963	transposase activity
K562_RS18445	COG3436	PFAM IS66 Orf2 family protein
K562_RS18450	COG4372	Transposase
K562_RS18475	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K562_RS18530	COG0154	amidase activity
K562_RS18560	COG3153	acetyltransferase
K562_RS18565	COG4804	nuclease activity
K562_RS18570	COG4804	nuclease activity
K562_RS18590	COG0589	response to stress
K562_RS18600	COG0071	Belongs to the small heat shock protein (HSP20) family
K562_RS18650	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K562_RS18660	COG4585	Histidine kinase
K562_RS18665	COG0589	response to stress
K562_RS18675	COG0589	response to stress
K562_RS18680	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
K562_RS18695	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS18715	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
K562_RS18725	COG0842	Transport permease protein
K562_RS18730	COG1129	ABC transporter
K562_RS18730	COG0842	Transport permease protein
K562_RS18735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K562_RS18765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
K562_RS18810	COG0589	response to stress
K562_RS18830	COG0642	Histidine kinase
K562_RS18875	COG2948	multi-organism process
K562_RS18920	COG0583	DNA-binding transcription factor activity
K562_RS18945	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
K562_RS18970	COG5265	(ABC) transporter
K562_RS18975	COG0667	Aldo Keto reductase
K562_RS18980	COG0583	DNA-binding transcription factor activity
K562_RS19010	COG3537	Alpha-1,2-mannosidase
K562_RS19015	COG3537	Alpha-1,2-mannosidase
K562_RS19040	COG1522	sequence-specific DNA binding
K562_RS19070	COG0477	Major facilitator Superfamily
K562_RS19075	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K562_RS19085	COG0432	Pfam Uncharacterised protein family UPF0047
K562_RS19090	COG2205	protein histidine kinase activity
K562_RS19090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K562_RS19120	COG2515	1-aminocyclopropane-1-carboxylate deaminase
K562_RS19125	COG1522	sequence-specific DNA binding
K562_RS19130	COG0028	Belongs to the TPP enzyme family
K562_RS19140	COG1785	Belongs to the alkaline phosphatase family
K562_RS19155	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K562_RS19155	COG2755	lipolytic protein G-D-S-L family
K562_RS19175	COG0583	DNA-binding transcription factor activity
K562_RS19190	COG0583	DNA-binding transcription factor activity
K562_RS19200	COG1513	Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide
K562_RS19205	COG0590	tRNA wobble adenosine to inosine editing
K562_RS19215	COG0583	DNA-binding transcription factor activity
K562_RS19220	COG4106	trans-aconitate 2-methyltransferase activity
K562_RS19230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS19235	COG3511	phospholipase C
K562_RS19255	COG1285	pathogenesis
K562_RS19260	COG1349	DNA-binding transcription factor activity
K562_RS19300	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K562_RS19310	COG0583	DNA-binding transcription factor activity
K562_RS19340	COG2271	Major facilitator Superfamily
K562_RS19355	COG1733	regulation of RNA biosynthetic process
K562_RS19360	COG0625	glutathione transferase activity
K562_RS19375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K562_RS19380	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K562_RS19495	COG1126	abc transporter atp-binding protein
K562_RS19500	COG0765	amino acid transport
K562_RS19505	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K562_RS19510	COG0626	cystathionine gamma-synthase activity
K562_RS19515	COG0583	DNA-binding transcription factor activity
K562_RS19520	COG2814	Major facilitator Superfamily
K562_RS19525	COG0583	DNA-binding transcription factor activity
K562_RS19540	COG1012	belongs to the aldehyde dehydrogenase family
K562_RS19590	COG1522	sequence-specific DNA binding
K562_RS19605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
K562_RS19615	COG2271	Major facilitator Superfamily
K562_RS19620	COG1609	Transcriptional regulator
K562_RS19625	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K562_RS19645	COG1902	pentaerythritol trinitrate reductase activity
K562_RS19650	COG4774	siderophore transport
K562_RS19680	COG1280	lysine exporter protein (LysE YggA)
K562_RS19690	COG1012	belongs to the aldehyde dehydrogenase family
K562_RS19705	COG0583	DNA-binding transcription factor activity
K562_RS19730	COG2197	response regulator
K562_RS19735	COG3237	CsbD-like
K562_RS19745	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K562_RS19745	COG2022	thiamine diphosphate biosynthetic process
K562_RS19795	COG0281	malic enzyme
K562_RS19795	COG0280	phosphate acetyltransferase
K562_RS19800	COG1404	Belongs to the peptidase S8 family
K562_RS19820	COG0464	growth
K562_RS19825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K562_RS19835	COG0259	pyridoxamine-phosphate oxidase activity
K562_RS19845	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS19850	COG0596	Alpha beta hydrolase
K562_RS19900	COG0154	amidase activity
K562_RS19910	COG1045	serine acetyltransferase
K562_RS19915	COG1396	sequence-specific DNA binding
K562_RS19920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K562_RS19925	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
K562_RS19930	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
K562_RS19960	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
K562_RS19975	COG3829	transcription factor binding
K562_RS19980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K562_RS19985	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K562_RS19990	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K562_RS20035	COG4771	TonB-dependent receptor
K562_RS20040	COG1064	alcohol dehydrogenase
K562_RS20055	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS20065	COG1262	PFAM Formylglycine-generating sulfatase enzyme
K562_RS20070	COG1464	Belongs to the NlpA lipoprotein family
K562_RS20095	COG4336	lyase activity
K562_RS20100	COG2814	Major facilitator Superfamily
K562_RS20110	COG5001	Diguanylate cyclase
K562_RS20115	COG1024	Enoyl-CoA hydratase
K562_RS20145	COG0667	Aldo Keto reductase
K562_RS20175	COG0625	glutathione transferase activity
K562_RS20180	COG1011	Hydrolase
K562_RS20195	COG0583	DNA-binding transcription factor activity
K562_RS20200	COG0583	DNA-binding transcription factor activity
K562_RS20205	COG1454	alcohol dehydrogenase
K562_RS20210	COG0477	Major facilitator Superfamily
K562_RS20230	COG0443	Heat shock 70 kDa protein
K562_RS20245	COG2423	ornithine cyclodeaminase activity
K562_RS20250	COG1522	sequence-specific DNA binding
K562_RS20265	COG2072	flavoprotein involved in K transport
K562_RS20270	COG0583	DNA-binding transcription factor activity
K562_RS20355	COG0586	Pfam SNARE associated Golgi protein
K562_RS20365	COG3657	addiction module killer protein
K562_RS20370	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
K562_RS20400	COG1522	sequence-specific DNA binding
K562_RS20420	COG4566	intracellular signal transduction
K562_RS20430	COG0154	amidase activity
K562_RS20445	COG1960	acyl-CoA dehydrogenase activity
K562_RS20450	COG4191	Histidine kinase
K562_RS20465	COG4638	Rieske (2fe-2S)
K562_RS20480	COG2271	Major facilitator Superfamily
K562_RS20485	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS20490	COG0583	DNA-binding transcription factor activity
K562_RS20500	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
K562_RS20505	COG1250	3-hydroxyacyl-CoA dehydrogenase
K562_RS20515	COG0583	DNA-binding transcription factor activity
K562_RS20520	COG0318	PFAM AMP-dependent synthetase and ligase
K562_RS20525	COG1960	acyl-CoA dehydrogenase activity
K562_RS20540	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS20560	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K562_RS20575	COG1177	transmembrane transport
K562_RS20580	COG1176	ABC-type spermidine putrescine transport system, permease component I
K562_RS20585	COG3842	ATPase activity
K562_RS20595	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS20655	COG0456	acetyltransferase
K562_RS20675	COG2885	chlorophyll binding
K562_RS20685	COG0431	NADPH-dependent FMN reductase
K562_RS20740	COG0625	glutathione transferase activity
K562_RS20765	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K562_RS20840	COG4122	O-methyltransferase activity
K562_RS20855	COG3541	Predicted nucleotidyltransferase
K562_RS20860	COG1690	Belongs to the RtcB family
K562_RS20895	COG1104	cysteine desulfurase activity
K562_RS20905	COG2368	4-hydroxyphenylacetate
K562_RS20920	COG2226	methyltransferase
K562_RS20920	COG1073	alpha beta
K562_RS20945	COG0583	DNA-binding transcription factor activity
K562_RS20965	COG0137	argininosuccinate synthase activity
K562_RS20970	COG1289	transmembrane transporter activity
K562_RS20980	COG0833	amino acid
K562_RS20990	COG0583	DNA-binding transcription factor activity
K562_RS21040	COG4160	amino acid transport
K562_RS21055	COG1609	Transcriptional regulator
K562_RS21065	COG1879	ABC-type sugar transport system periplasmic component
K562_RS21070	COG1129	ABC transporter
K562_RS21075	COG1172	Belongs to the binding-protein-dependent transport system permease family
K562_RS21080	COG1172	Belongs to the binding-protein-dependent transport system permease family
K562_RS21105	COG3243	poly(R)-hydroxyalkanoic acid synthase
K562_RS21120	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
K562_RS21135	COG0556	nucleotide-excision repair
K562_RS21145	COG1228	amidohydrolase
K562_RS21185	COG1566	PFAM secretion protein HlyD family protein
K562_RS21195	COG0583	DNA-binding transcription factor activity
K562_RS21220	COG0446	pyridine nucleotide-disulphide oxidoreductase
K562_RS21220	COG1902	pentaerythritol trinitrate reductase activity
K562_RS21230	COG0583	DNA-binding transcription factor activity
K562_RS21235	COG2249	NAD(P)H dehydrogenase (quinone) activity
K562_RS21275	COG4638	Rieske (2fe-2S)
K562_RS21280	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
K562_RS21285	COG2146	nitrite reductase [NAD(P)H] activity
K562_RS21295	COG2733	membrane
K562_RS21300	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
K562_RS21305	COG3657	addiction module killer protein
K562_RS21315	COG1012	belongs to the aldehyde dehydrogenase family
K562_RS21320	COG0025	NhaP-type Na H and K H
K562_RS21325	COG0745	RESPONSE REGULATOR receiver
K562_RS21330	COG0840	transmembrane signaling receptor activity
K562_RS21360	COG0038	chloride channel
K562_RS21370	COG0307	riboflavin synthase, alpha
K562_RS21380	COG5265	(ABC) transporter
K562_RS21385	COG2837	iron assimilation
K562_RS21405	COG1914	H( )-stimulated, divalent metal cation uptake system
K562_RS21420	COG2130	NADP-dependent
K562_RS21430	COG0628	permease
K562_RS21450	COG3795	YCII-related domain
K562_RS21455	COG3795	YCII-related domain
K562_RS21465	COG4941	Belongs to the sigma-70 factor family
K562_RS21470	COG1592	Rubrerythrin
K562_RS21475	COG0247	lactate metabolic process
K562_RS21510	COG1596	polysaccharide export
K562_RS21515	COG3206	protein involved in exopolysaccharide biosynthesis
K562_RS21515	COG0489	protein tyrosine kinase activity
K562_RS21535	COG0438	transferase activity, transferring glycosyl groups
K562_RS21540	COG0438	transferase activity, transferring glycosyl groups
K562_RS21545	COG2814	Major facilitator Superfamily
K562_RS21560	COG3708	Transcriptional regulator
K562_RS21560	COG2207	Transcriptional regulator
K562_RS21575	COG2204	response regulator
K562_RS21595	COG5642	Protein of unknown function (DUF2384)
K562_RS21600	COG5654	RES domain protein
K562_RS21605	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
K562_RS21625	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
K562_RS21630	COG0352	thiamine-phosphate diphosphorylase activity
K562_RS21635	COG1253	flavin adenine dinucleotide binding
K562_RS21650	COG0583	DNA-binding transcription factor activity
K562_RS21655	COG1942	4-Oxalocrotonate Tautomerase
K562_RS21670	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
K562_RS21675	COG4149	molybdate abc transporter
K562_RS21680	COG0725	ABC transporter, periplasmic molybdate-binding protein
K562_RS21700	COG1764	response to oxidative stress
K562_RS21705	COG1846	Transcriptional regulator
K562_RS21715	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
K562_RS21725	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
K562_RS21735	COG1611	Belongs to the LOG family
K562_RS21745	COG1252	NADH dehydrogenase
K562_RS21750	COG0412	Dienelactone hydrolase
K562_RS21770	COG0142	geranyltranstransferase activity
K562_RS21775	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
K562_RS21785	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
K562_RS21790	COG2081	HI0933 family
K562_RS21810	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K562_RS21820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
K562_RS21845	COG0745	RESPONSE REGULATOR receiver
K562_RS21855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K562_RS21880	COG0753	catalase activity
K562_RS21905	COG0668	transmembrane transport
K562_RS21930	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
K562_RS21955	COG3038	cytochrome b561
K562_RS21965	COG4771	TonB-dependent receptor
K562_RS21970	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
K562_RS21975	COG5380	lipid catabolic process
K562_RS21985	COG3842	ATPase activity
K562_RS21995	COG1176	ABC-type spermidine putrescine transport system, permease component I
K562_RS22000	COG1177	transmembrane transport
K562_RS22005	COG2814	Major facilitator Superfamily
K562_RS22030	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
K562_RS22050	COG0039	L-malate dehydrogenase activity
K562_RS22055	COG2188	Transcriptional regulator
K562_RS22060	COG2009	succinate dehydrogenase
K562_RS22070	COG1053	succinate dehydrogenase
K562_RS22075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
K562_RS22080	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
K562_RS22085	COG0372	Belongs to the citrate synthase family
K562_RS22110	COG1522	sequence-specific DNA binding
K562_RS22115	COG0833	amino acid
K562_RS22145	COG5510	response to toxic substance
K562_RS22190	COG0135	phosphoribosylanthranilate isomerase activity
K562_RS22195	COG0133	tryptophan synthase activity
K562_RS22205	COG0159	tryptophan synthase activity
K562_RS22210	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
K562_RS22215	COG0285	dihydrofolate synthase activity
K562_RS22245	COG3344	reverse transcriptase
K562_RS22250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
K562_RS22255	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
K562_RS22260	COG2755	lipolytic protein G-D-S-L family
K562_RS22260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K562_RS22290	COG1210	Utp--glucose-1-phosphate uridylyltransferase
K562_RS22295	COG2755	lipolytic protein G-D-S-L family
K562_RS22295	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K562_RS22320	COG1295	ribonuclease BN
K562_RS22330	COG0437	4 iron, 4 sulfur cluster binding
K562_RS22335	COG2864	formate dehydrogenase
K562_RS22350	COG3276	selenocysteine insertion sequence binding
K562_RS22360	COG0582	viral genome integration into host DNA
K562_RS22540	COG3567	Phage-associated protein, HI1409 family
K562_RS22680	COG3179	chitinase
K562_RS22710	COG0494	nUDIX hydrolase
K562_RS22715	COG2233	PERMEase
K562_RS22735	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
K562_RS22740	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
K562_RS22745	COG0277	FAD linked oxidase domain protein
K562_RS22760	COG1454	alcohol dehydrogenase
K562_RS22765	COG2814	Major facilitator Superfamily
K562_RS22770	COG1982	Orn Lys Arg decarboxylase major
K562_RS22775	COG1982	Orn Lys Arg decarboxylase major
K562_RS22780	COG0531	amino acid
K562_RS22785	COG0583	DNA-binding transcription factor activity
K562_RS22805	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K562_RS22815	COG0747	negative chemotaxis
K562_RS22820	COG2175	clavaminate synthase activity
K562_RS22835	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K562_RS22840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K562_RS22890	COG1953	Uracil, thiamine, allantoin
K562_RS22910	COG2271	Major facilitator Superfamily
K562_RS22915	COG1846	Transcriptional regulator
K562_RS22920	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K562_RS22920	COG2010	Cytochrome c
K562_RS22925	COG1335	isochorismatase
K562_RS22930	COG2309	aminopeptidase activity
K562_RS22935	COG0596	Alpha beta hydrolase
K562_RS22940	COG3473	Maleate cis-trans isomerase
K562_RS22945	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K562_RS22950	COG2080	2 iron, 2 sulfur cluster binding
K562_RS22955	COG2010	Cytochrome c
K562_RS22955	COG1529	Aldehyde oxidase and xanthine dehydrogenase
K562_RS22975	COG0477	Major facilitator Superfamily
K562_RS23000	COG0583	DNA-binding transcription factor activity
K562_RS23005	COG3119	arylsulfatase activity
K562_RS23010	COG0583	DNA-binding transcription factor activity
K562_RS23020	COG2203	Gaf domain
K562_RS23020	COG3706	GGDEF domain
K562_RS23020	COG5001	Diguanylate cyclase
K562_RS23020	COG4251	negative regulation of phosphorylation
K562_RS23060	COG1414	Transcriptional regulator
K562_RS23065	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
K562_RS23080	COG1113	amino acid transport
K562_RS23085	COG0243	molybdopterin cofactor binding
K562_RS23090	COG0437	4 iron, 4 sulfur cluster binding
K562_RS23095	COG3302	dmso reductase anchor subunit
K562_RS23100	COG1414	Transcriptional regulator
K562_RS23115	COG0730	response to heat
K562_RS23135	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K562_RS23145	COG1012	belongs to the aldehyde dehydrogenase family
K562_RS23150	COG4774	siderophore transport
K562_RS23160	COG0583	DNA-binding transcription factor activity
K562_RS23165	COG1027	Aspartate ammonia-lyase
K562_RS23175	COG0400	carboxylic ester hydrolase activity
K562_RS23180	COG4456	Virulence-associated protein
K562_RS23200	COG0840	transmembrane signaling receptor activity
K562_RS23235	COG1024	Enoyl-CoA hydratase
K562_RS23240	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
K562_RS23260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K562_RS23265	COG0765	amino acid transport
K562_RS23270	COG1126	abc transporter atp-binding protein
K562_RS23280	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K562_RS23300	COG3634	alkyl hydroperoxide reductase activity
K562_RS23350	COG1215	transferase activity, transferring glycosyl groups
K562_RS23355	COG0726	polysaccharide deacetylase
K562_RS23355	COG1649	PFAM Uncharacterised BCR, COG1649
K562_RS23375	COG0583	DNA-binding transcription factor activity
K562_RS23380	COG2308	Evidence 4 Homologs of previously reported genes of
K562_RS23405	COG1305	Transglutaminase-like
K562_RS23420	COG2755	lipolytic protein G-D-S-L family
K562_RS23420	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
K562_RS23435	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
K562_RS23440	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
K562_RS23440	COG0028	Belongs to the TPP enzyme family
K562_RS23475	COG2814	Major facilitator Superfamily
K562_RS23495	COG0789	Transcriptional regulator
K562_RS23520	COG0129	dihydroxy-acid dehydratase activity
K562_RS23525	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K562_RS23535	COG0531	amino acid
K562_RS23540	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K562_RS23545	COG3938	Belongs to the proline racemase family
K562_RS23550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K562_RS23580	COG0625	glutathione transferase activity
K562_RS23585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K562_RS23590	COG2271	Major facilitator Superfamily
K562_RS23595	COG0640	Transcriptional regulator
K562_RS23600	COG2391	methyltransferase activity
K562_RS23615	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K562_RS23625	COG1858	cytochrome C peroxidase
K562_RS23635	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
K562_RS23635	COG4106	trans-aconitate 2-methyltransferase activity
K562_RS23645	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
K562_RS23660	COG2271	Major facilitator Superfamily
K562_RS23675	COG4172	Belongs to the ABC transporter superfamily
K562_RS23680	COG0747	negative chemotaxis
K562_RS23690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K562_RS23710	COG3485	protocatechuate 3,4-dioxygenase
K562_RS23715	COG3485	protocatechuate 3,4-dioxygenase
K562_RS23730	COG0583	DNA-binding transcription factor activity
K562_RS23745	COG0531	amino acid
K562_RS23750	COG1201	RNA secondary structure unwinding
K562_RS23790	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
K562_RS23835	COG1739	Uncharacterized protein family UPF0029
K562_RS23840	COG0583	DNA-binding transcription factor activity
K562_RS23850	COG1472	Belongs to the glycosyl hydrolase 3 family
K562_RS23945	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
K562_RS23955	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
K562_RS23970	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
K562_RS23980	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
K562_RS23980	COG1796	DNA polymerase
K562_RS23985	COG0686	Belongs to the AlaDH PNT family
K562_RS24015	COG4651	solute:proton antiporter activity
K562_RS24015	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K562_RS24045	COG1846	Transcriptional regulator
K562_RS24060	COG1012	belongs to the aldehyde dehydrogenase family
K562_RS24065	COG3384	dioxygenase
K562_RS24075	COG3971	2-oxopent-4-enoate hydratase activity
K562_RS24085	COG2207	Transcriptional regulator
K562_RS24105	COG3842	ATPase activity
K562_RS24110	COG4208	sulfate ABC transporter
K562_RS24135	COG0642	Histidine kinase
K562_RS24155	COG1116	anion transmembrane transporter activity
K562_RS24165	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K562_RS24180	COG1960	acyl-CoA dehydrogenase activity
K562_RS24205	COG1562	ergosterol biosynthetic process
K562_RS24210	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS24220	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K562_RS24230	COG0583	DNA-binding transcription factor activity
K562_RS24240	COG1621	beta-fructofuranosidase activity
K562_RS24260	COG1902	pentaerythritol trinitrate reductase activity
K562_RS24275	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS24305	COG0642	Histidine kinase
K562_RS24315	COG1538	Outer membrane efflux protein
K562_RS24320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K562_RS24335	COG0318	PFAM AMP-dependent synthetase and ligase
K562_RS24340	COG0840	transmembrane signaling receptor activity
K562_RS24345	COG1238	metal cluster binding
K562_RS24350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K562_RS24355	COG1280	lysine exporter protein (LysE YggA)
K562_RS24380	COG2271	Major facilitator Superfamily
K562_RS24385	COG4221	oxidoreductase activity
K562_RS24395	COG0596	Alpha beta hydrolase
K562_RS24440	COG0697	spore germination
K562_RS24450	COG0583	DNA-binding transcription factor activity
K562_RS24485	COG0583	DNA-binding transcription factor activity
K562_RS24505	COG0402	S-adenosylhomocysteine deaminase activity
K562_RS24510	COG0038	chloride channel
K562_RS24515	COG2031	fatty acid transporter
K562_RS24560	COG0765	amino acid transport
K562_RS24570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K562_RS24575	COG0438	transferase activity, transferring glycosyl groups
K562_RS24580	COG1858	cytochrome C peroxidase
K562_RS24585	COG3511	phospholipase C
K562_RS24595	COG1522	sequence-specific DNA binding
K562_RS24600	COG1113	amino acid transport
K562_RS24605	COG1448	Aminotransferase
K562_RS24630	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
K562_RS24635	COG2204	response regulator
K562_RS24660	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K562_RS24735	COG2204	response regulator
K562_RS24740	COG2205	protein histidine kinase activity
K562_RS24740	COG2198	Histidine kinase
K562_RS24740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K562_RS24740	COG0784	Response regulator, receiver
K562_RS24800	COG1414	Transcriptional regulator
K562_RS24815	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
K562_RS24820	COG1403	HNH endonuclease
K562_RS24825	COG0477	Major facilitator Superfamily
K562_RS24880	COG2197	response regulator
K562_RS24900	COG1309	transcriptional regulator
K562_RS24905	COG2130	NADP-dependent
K562_RS24975	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS24990	COG2010	Cytochrome c
K562_RS25015	COG3608	succinylglutamate desuccinylase aspartoacylase
K562_RS25025	COG2974	May be involved in recombination
K562_RS25035	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K562_RS25040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K562_RS25045	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K562_RS25050	COG1126	abc transporter atp-binding protein
K562_RS25060	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K562_RS25065	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K562_RS25075	COG1846	Transcriptional regulator
K562_RS25090	COG4206	TonB-dependent receptor
K562_RS25100	COG0840	transmembrane signaling receptor activity
K562_RS25105	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
K562_RS25150	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
K562_RS25165	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS25190	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
K562_RS25215	COG4206	TonB-dependent receptor
K562_RS25235	COG1522	sequence-specific DNA binding
K562_RS25295	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS25315	COG4569	acetaldehyde dehydrogenase (acetylating) activity
K562_RS25320	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K562_RS25340	COG1278	Cold shock
K562_RS25360	COG0183	Belongs to the thiolase family
K562_RS25375	COG1960	acyl-CoA dehydrogenase activity
K562_RS25385	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS25395	COG1960	acyl-CoA dehydrogenase activity
K562_RS25400	COG1960	acyl-CoA dehydrogenase activity
K562_RS25415	COG1024	Enoyl-CoA hydratase
K562_RS25455	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS25470	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K562_RS25475	COG1053	succinate dehydrogenase
K562_RS25480	COG1960	acyl-CoA dehydrogenase activity
K562_RS25495	COG0583	DNA-binding transcription factor activity
K562_RS25515	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS25570	COG1280	lysine exporter protein (LysE YggA)
K562_RS25595	COG5001	Diguanylate cyclase
K562_RS25595	COG3300	MHYT domain
K562_RS25600	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
K562_RS25605	COG2186	Transcriptional regulator
K562_RS25610	COG1312	Catalyzes the dehydration of D-mannonate
K562_RS25615	COG2271	Major facilitator Superfamily
K562_RS25620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K562_RS25645	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
K562_RS25645	COG0392	lysyltransferase activity
K562_RS25665	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS25670	COG0243	molybdopterin cofactor binding
K562_RS25675	COG2146	nitrite reductase [NAD(P)H] activity
K562_RS25680	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
K562_RS25700	COG3707	response regulator
K562_RS25705	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K562_RS25705	COG1116	anion transmembrane transporter activity
K562_RS25710	COG1573	uracil-dna glycosylase
K562_RS25720	COG0179	Fumarylacetoacetate (FAA) hydrolase
K562_RS25730	COG2814	Major facilitator Superfamily
K562_RS25735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
K562_RS25780	COG1063	alcohol dehydrogenase
K562_RS25800	COG0667	Aldo Keto reductase
K562_RS25810	COG1024	Enoyl-CoA hydratase
K562_RS25810	COG1250	3-hydroxyacyl-CoA dehydrogenase
K562_RS25820	COG1250	3-hydroxyacyl-CoA dehydrogenase
K562_RS25830	COG0387	Pfam Sodium calcium exchanger
K562_RS25840	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K562_RS25845	COG1609	Transcriptional regulator
K562_RS25850	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
K562_RS25855	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K562_RS25860	COG0583	DNA-binding transcription factor activity
K562_RS25865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K562_RS25870	COG2271	Major facilitator Superfamily
K562_RS25875	COG0583	DNA-binding transcription factor activity
K562_RS25905	COG0583	DNA-binding transcription factor activity
K562_RS25910	COG1473	amidohydrolase
K562_RS25930	COG2259	Doxx family
K562_RS25950	COG2373	Large extracellular alpha-helical protein
K562_RS25955	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
K562_RS25975	COG2814	Major facilitator Superfamily
K562_RS25985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K562_RS25990	COG1404	Belongs to the peptidase S8 family
K562_RS26005	COG0583	DNA-binding transcription factor activity
K562_RS26030	COG1335	isochorismatase
K562_RS26035	COG2814	Major facilitator Superfamily
K562_RS26050	COG0668	transmembrane transport
K562_RS26055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K562_RS26060	COG0243	molybdopterin cofactor binding
K562_RS26065	COG3781	membrane
K562_RS26070	COG1289	transmembrane transporter activity
K562_RS26075	COG0583	DNA-binding transcription factor activity
K562_RS26080	COG2814	Major facilitator Superfamily
K562_RS26090	COG4166	transmembrane transport
K562_RS26100	COG1914	H( )-stimulated, divalent metal cation uptake system
K562_RS26105	COG2140	Oxalate decarboxylase
K562_RS26110	COG3550	peptidyl-serine autophosphorylation
K562_RS26125	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
K562_RS26135	COG0601	transmembrane transport
K562_RS26140	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K562_RS26150	COG4172	Belongs to the ABC transporter superfamily
K562_RS26155	COG2261	transglycosylase associated protein
K562_RS26170	COG0583	DNA-binding transcription factor activity
K562_RS26185	COG0583	DNA-binding transcription factor activity
K562_RS26205	COG0667	Aldo Keto reductase
K562_RS26210	COG0583	DNA-binding transcription factor activity
K562_RS26215	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS26260	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
K562_RS26295	COG0840	transmembrane signaling receptor activity
K562_RS26325	COG1278	Cold shock
K562_RS26335	COG0010	Belongs to the arginase family
K562_RS26360	COG0596	Alpha beta hydrolase
K562_RS26380	COG1942	4-Oxalocrotonate Tautomerase
K562_RS26390	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
K562_RS26405	COG2162	N-hydroxyarylamine O-acetyltransferase activity
K562_RS26415	COG0154	amidase activity
K562_RS26450	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
K562_RS26470	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
K562_RS26475	COG0477	Major facilitator Superfamily
K562_RS26490	COG1012	belongs to the aldehyde dehydrogenase family
K562_RS26500	COG0028	Belongs to the TPP enzyme family
K562_RS26505	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS26510	COG1414	Transcriptional regulator
K562_RS26515	COG2226	methyltransferase
K562_RS26515	COG1073	alpha beta
K562_RS26525	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS26540	COG2146	nitrite reductase [NAD(P)H] activity
K562_RS26545	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS26550	COG1414	Transcriptional regulator
K562_RS26575	COG0583	DNA-binding transcription factor activity
K562_RS26590	COG1289	transmembrane transporter activity
K562_RS26600	COG1285	pathogenesis
K562_RS26605	COG2197	response regulator
K562_RS26635	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
K562_RS26665	COG3617	BRO family, N-terminal domain
K562_RS26880	COG0516	GMP reductase activity
K562_RS26880	COG0517	IMP dehydrogenase activity
K562_RS26890	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
K562_RS26900	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS26910	COG1733	regulation of RNA biosynthetic process
K562_RS26925	COG1574	metal-dependent hydrolase with the TIM-barrel fold
K562_RS26960	COG0625	glutathione transferase activity
K562_RS26965	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
K562_RS26995	COG0789	Transcriptional regulator
K562_RS27000	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS27005	COG0583	DNA-binding transcription factor activity
K562_RS27025	COG1301	dicarboxylic acid transport
K562_RS27040	COG1116	anion transmembrane transporter activity
K562_RS27045	COG1176	ABC-type spermidine putrescine transport system, permease component I
K562_RS27080	COG0546	phosphoglycolate phosphatase activity
K562_RS27090	COG1902	pentaerythritol trinitrate reductase activity
K562_RS27105	COG1609	Transcriptional regulator
K562_RS27115	COG1175	transmembrane transport
K562_RS27120	COG1653	transport
K562_RS27150	COG1012	belongs to the aldehyde dehydrogenase family
K562_RS27165	COG2321	neutral zinc metallopeptidase
K562_RS27195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K562_RS27215	COG0477	Major facilitator Superfamily
K562_RS27230	COG4452	Inner membrane protein CreD
K562_RS27235	COG2205	protein histidine kinase activity
K562_RS27240	COG0745	RESPONSE REGULATOR receiver
K562_RS27255	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS27265	COG1917	Cupin 2, conserved barrel domain protein
K562_RS27265	COG2207	Transcriptional regulator
K562_RS27285	COG0540	Belongs to the ATCase OTCase family
K562_RS27300	COG4774	siderophore transport
K562_RS27340	COG1070	Carbohydrate kinase
K562_RS27345	COG1063	alcohol dehydrogenase
K562_RS27350	COG1172	Belongs to the binding-protein-dependent transport system permease family
K562_RS27360	COG1879	ABC-type sugar transport system periplasmic component
K562_RS27370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K562_RS27375	COG0840	transmembrane signaling receptor activity
K562_RS27450	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
K562_RS27455	COG1215	transferase activity, transferring glycosyl groups
K562_RS27460	COG2207	Transcriptional regulator
K562_RS27475	COG0745	RESPONSE REGULATOR receiver
K562_RS27505	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
K562_RS27510	COG1684	flagellar biosynthetic protein fliR
K562_RS27555	COG1450	Type ii and iii secretion system protein
K562_RS27560	COG4794	Type iii secretion
K562_RS27565	COG4789	Type iii secretion
K562_RS27600	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
K562_RS27610	COG0477	Major facilitator Superfamily
K562_RS27615	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
K562_RS27625	COG3214	Protein conserved in bacteria
K562_RS27635	COG0546	phosphoglycolate phosphatase activity
K562_RS27650	COG0583	DNA-binding transcription factor activity
K562_RS27660	COG0697	spore germination
K562_RS27665	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K562_RS27675	COG1056	cytidyltransferase-related domain
K562_RS27675	COG1051	belongs to the nudix hydrolase family
K562_RS27685	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
K562_RS27710	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
K562_RS27740	COG0583	DNA-binding transcription factor activity
K562_RS27745	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
K562_RS27750	COG0174	glutamine synthetase
K562_RS27760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K562_RS27790	COG0789	Transcriptional regulator
K562_RS27800	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
K562_RS27805	COG3321	synthase
K562_RS27805	COG0604	alcohol dehydrogenase
K562_RS27820	COG0753	catalase activity
K562_RS27830	COG0006	proline dipeptidase activity
K562_RS27865	COG2272	Belongs to the type-B carboxylesterase lipase family
K562_RS27875	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K562_RS27880	COG4569	acetaldehyde dehydrogenase (acetylating) activity
K562_RS27890	COG3971	2-oxopent-4-enoate hydratase activity
K562_RS27920	COG4101	3-hydroxyanthranilate 3,4-dioxygenase activity
K562_RS27975	COG2274	protein secretion by the type I secretion system
K562_RS27995	COG1113	amino acid transport
K562_RS28010	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
K562_RS28025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
K562_RS28035	COG2124	cytochrome p450
K562_RS28075	COG0642	Histidine kinase
K562_RS28130	COG1077	Cell shape determining protein MreB Mrl
K562_RS28145	COG2205	protein histidine kinase activity
K562_RS28150	COG0745	RESPONSE REGULATOR receiver
K562_RS28155	COG2066	Belongs to the glutaminase family
K562_RS28200	COG2813	Specifically methylates the guanine in position
K562_RS28205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K562_RS28215	COG1538	Outer membrane efflux protein
K562_RS28220	COG0477	Major facilitator Superfamily
K562_RS28230	COG1024	Enoyl-CoA hydratase
K562_RS28235	COG1024	Enoyl-CoA hydratase
K562_RS28250	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K562_RS28255	COG1960	acyl-CoA dehydrogenase activity
K562_RS28270	COG0330	HflC and HflK could
K562_RS28320	COG2252	PERMEase
K562_RS28335	COG3284	Transcriptional regulator
K562_RS28370	COG1280	lysine exporter protein (LysE YggA)
K562_RS28390	COG2814	Major facilitator Superfamily
K562_RS28415	COG1132	(ABC) transporter
K562_RS28420	COG2375	cellular response to nickel ion
K562_RS28420	COG1132	(ABC) transporter
K562_RS28435	COG2226	methyltransferase
K562_RS28435	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
K562_RS28435	COG3433	isochorismatase activity
K562_RS28465	COG0583	DNA-binding transcription factor activity
K562_RS28470	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K562_RS28475	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS28515	COG0583	DNA-binding transcription factor activity
K562_RS28560	COG3209	COG3209 Rhs family protein
K562_RS28580	COG2199	diguanylate cyclase activity
K562_RS28590	COG0583	DNA-binding transcription factor activity
K562_RS28595	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
K562_RS28600	COG2271	Major facilitator Superfamily
K562_RS28625	COG0583	DNA-binding transcription factor activity
K562_RS28640	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
K562_RS28655	COG2233	PERMEase
K562_RS28690	COG2186	Transcriptional regulator
K562_RS28695	COG3618	amidohydrolase
K562_RS28705	COG1172	Belongs to the binding-protein-dependent transport system permease family
K562_RS28715	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS28720	COG4948	Mandelate Racemase Muconate Lactonizing
K562_RS28725	COG0179	Fumarylacetoacetate (FAA) hydrolase
K562_RS28730	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS28740	COG4221	oxidoreductase activity
K562_RS28755	COG0657	acetylesterase activity
K562_RS28765	COG1250	3-hydroxyacyl-CoA dehydrogenase
K562_RS28770	COG3246	L-lysine catabolic process to acetate
K562_RS28795	COG1012	belongs to the aldehyde dehydrogenase family
K562_RS28815	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
K562_RS28830	COG2207	Transcriptional regulator
K562_RS28850	COG0393	Putative heavy-metal-binding
K562_RS28855	COG2814	Major facilitator Superfamily
K562_RS28870	COG3119	arylsulfatase activity
K562_RS28890	COG2113	Glycine betaine
K562_RS28900	COG4638	Rieske (2fe-2S)
K562_RS28910	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
K562_RS28915	COG0247	lactate metabolic process
K562_RS28915	COG2181	nitrate reductase activity
K562_RS28920	COG0446	pyridine nucleotide-disulphide oxidoreductase
K562_RS28920	COG1902	pentaerythritol trinitrate reductase activity
K562_RS28950	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K562_RS28965	COG0583	DNA-binding transcription factor activity
K562_RS28990	COG2814	Major facilitator Superfamily
K562_RS29010	COG1309	transcriptional regulator
K562_RS29015	COG1012	belongs to the aldehyde dehydrogenase family
K562_RS29020	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
K562_RS29055	COG1131	(ABC) transporter
K562_RS29060	COG0842	Transport permease protein
K562_RS29065	COG2814	Major facilitator Superfamily
K562_RS29085	COG3795	YCII-related domain
K562_RS29095	COG2267	carboxylic ester hydrolase activity
K562_RS29100	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
K562_RS29120	COG0535	radical SAM domain protein
K562_RS29130	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
K562_RS29135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
K562_RS29145	COG3284	Transcriptional regulator
K562_RS29175	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
K562_RS29190	COG0840	transmembrane signaling receptor activity
K562_RS29210	COG2936	dipeptidyl-peptidase activity
K562_RS29220	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K562_RS29225	COG1732	Glycine betaine
K562_RS29230	COG1174	glycine betaine transport
K562_RS29235	COG1125	glycine betaine transport
K562_RS29240	COG1174	glycine betaine transport
K562_RS29265	COG0404	The glycine cleavage system catalyzes the degradation of glycine
K562_RS29265	COG0446	pyridine nucleotide-disulphide oxidoreductase
K562_RS29280	COG1760	l-serine dehydratase
K562_RS29290	COG2186	Transcriptional regulator
K562_RS29295	COG2084	Dehydrogenase
K562_RS29300	COG3395	kinase activity
K562_RS29305	COG0235	Class ii aldolase
K562_RS29310	COG2271	Major facilitator Superfamily
K562_RS29315	COG3622	Belongs to the hyi family
K562_RS29320	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K562_RS29350	COG0583	DNA-binding transcription factor activity
K562_RS29380	COG4175	Glycine betaine
K562_RS29455	COG0859	PFAM glycosyl transferase family 9
K562_RS29455	COG0457	Tetratricopeptide repeat
K562_RS29465	COG2200	EAL domain
K562_RS29465	COG2199	diguanylate cyclase activity
K562_RS29465	COG3287	FIST C domain
K562_RS29480	COG3511	phospholipase C
K562_RS29495	COG1250	3-hydroxyacyl-CoA dehydrogenase
K562_RS29495	COG1024	Enoyl-CoA hydratase
K562_RS29500	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
K562_RS29505	COG1960	acyl-CoA dehydrogenase activity
K562_RS29555	COG3258	Cytochrome c
K562_RS29575	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS29580	COG1280	lysine exporter protein (LysE YggA)
K562_RS29595	COG0596	Alpha beta hydrolase
K562_RS29620	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
K562_RS29635	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
K562_RS29640	COG2252	PERMEase
K562_RS29655	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS29665	COG2271	Major facilitator Superfamily
K562_RS29670	COG1196	nuclear chromosome segregation
K562_RS29670	COG3264	Mechanosensitive ion channel
K562_RS29675	COG3344	reverse transcriptase
K562_RS29685	COG1012	belongs to the aldehyde dehydrogenase family
K562_RS29690	COG0833	amino acid
K562_RS29695	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K562_RS29710	COG1349	DNA-binding transcription factor activity
K562_RS29725	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
K562_RS29740	COG1280	lysine exporter protein (LysE YggA)
K562_RS29760	COG0477	Major facilitator Superfamily
K562_RS29765	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
K562_RS29770	COG0583	DNA-binding transcription factor activity
K562_RS29790	COG0306	phosphate transporter
K562_RS29800	COG0477	Major facilitator Superfamily
K562_RS29835	COG1012	belongs to the aldehyde dehydrogenase family
K562_RS29870	COG2271	Major facilitator Superfamily
K562_RS29875	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K562_RS29880	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
K562_RS29885	COG3185	4-Hydroxyphenylpyruvate dioxygenase
K562_RS29885	COG1082	Xylose isomerase domain protein TIM barrel
K562_RS29910	COG2259	Doxx family
K562_RS29925	COG2721	sulfolactate sulfo-lyase activity
K562_RS29945	COG2271	Major facilitator Superfamily
K562_RS29970	COG1522	sequence-specific DNA binding
K562_RS29975	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
K562_RS29995	COG0523	cobalamin synthesis protein
K562_RS30010	COG2011	ABC-type metal ion transport system permease component
K562_RS30030	COG3493	citrate carrier protein
K562_RS30035	COG4191	Histidine kinase
K562_RS30040	COG2204	response regulator
K562_RS30095	COG2271	Major facilitator Superfamily
K562_RS30130	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K562_RS30140	COG0583	DNA-binding transcription factor activity
K562_RS30160	COG0709	Synthesizes selenophosphate from selenide and ATP
K562_RS30175	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
K562_RS30185	COG0840	transmembrane signaling receptor activity
K562_RS30190	COG0840	transmembrane signaling receptor activity
K562_RS30205	COG1683	Conserved Protein
K562_RS30210	COG0183	Belongs to the thiolase family
K562_RS30215	COG1414	Transcriptional regulator
K562_RS30240	COG1473	amidohydrolase
K562_RS30245	COG0583	DNA-binding transcription factor activity
K562_RS30260	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS30280	COG2814	Major facilitator Superfamily
K562_RS30290	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS30300	COG3386	PFAM SMP-30 Gluconolaconase
K562_RS30305	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
K562_RS30310	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
K562_RS30315	COG1414	Transcriptional regulator
K562_RS30335	COG1309	transcriptional regulator
K562_RS30340	COG0604	alcohol dehydrogenase
K562_RS30350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
K562_RS30360	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS30365	COG1309	transcriptional regulator
K562_RS30370	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
K562_RS30375	COG0583	DNA-binding transcription factor activity
K562_RS30380	COG2814	Major facilitator Superfamily
K562_RS30390	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K562_RS30395	COG0656	L-ascorbic acid biosynthetic process
K562_RS30405	COG1902	pentaerythritol trinitrate reductase activity
K562_RS30430	COG2252	PERMEase
K562_RS30445	COG2814	Major facilitator Superfamily
K562_RS30455	COG0583	DNA-binding transcription factor activity
K562_RS30475	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS30495	COG4771	TonB-dependent receptor
K562_RS30500	COG3720	iron ion transport
K562_RS30505	COG4558	Periplasmic binding protein
K562_RS30510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
K562_RS30520	COG2860	membrane
K562_RS30550	COG3257	ureidoglycine aminohydrolase activity
K562_RS30580	COG0625	glutathione transferase activity
K562_RS30585	COG1090	epimerase
K562_RS30610	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
K562_RS30615	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS30660	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K562_RS30665	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
K562_RS30685	COG2814	Major facilitator Superfamily
K562_RS30715	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
K562_RS30730	COG1271	oxidase subunit
K562_RS30735	COG1294	oxidase, subunit
K562_RS30780	COG2217	Heavy metal translocating P-type atpase
K562_RS30800	COG1285	pathogenesis
K562_RS30810	COG0840	transmembrane signaling receptor activity
K562_RS30820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K562_RS30830	COG1024	Enoyl-CoA hydratase
K562_RS30850	COG2271	Major facilitator Superfamily
K562_RS30855	COG1960	acyl-CoA dehydrogenase activity
K562_RS30860	COG0657	acetylesterase activity
K562_RS30900	COG0179	Fumarylacetoacetate (FAA) hydrolase
K562_RS30920	COG2916	Histone family protein nucleoid-structuring protein H-NS
K562_RS30940	COG3604	Transcriptional regulator
K562_RS30945	COG2610	gluconate transmembrane transporter activity
K562_RS30960	COG1247	-acetyltransferase
K562_RS30985	COG4608	Belongs to the ABC transporter superfamily
K562_RS30995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K562_RS31000	COG0601	transmembrane transport
K562_RS31015	COG3104	oligopeptide transport
K562_RS31040	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
K562_RS31060	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
K562_RS31090	COG1272	protein, Hemolysin III
K562_RS31095	COG2879	small protein
K562_RS31100	COG1966	Carbon starvation protein
K562_RS31105	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
K562_RS31110	COG1595	DNA-templated transcription, initiation
K562_RS31115	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
K562_RS31125	COG0583	DNA-binding transcription factor activity
K562_RS31135	COG1764	response to oxidative stress
K562_RS31155	COG2205	protein histidine kinase activity
K562_RS31155	COG0784	Response regulator, receiver
K562_RS31155	COG2198	Histidine kinase
K562_RS31160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K562_RS31160	COG2198	Histidine kinase
K562_RS31160	COG0784	Response regulator, receiver
K562_RS31160	COG2205	protein histidine kinase activity
K562_RS31185	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
K562_RS31205	COG3132	Protein of unknown function, DUF480
K562_RS31210	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS31215	COG2258	MOSC domain
K562_RS31220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
K562_RS31225	COG0235	Class ii aldolase
K562_RS31230	COG1396	sequence-specific DNA binding
K562_RS31235	COG2188	Transcriptional regulator
K562_RS31250	COG0583	DNA-binding transcription factor activity
K562_RS31285	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
K562_RS31290	COG1473	amidohydrolase
K562_RS31300	COG1522	sequence-specific DNA binding
K562_RS31310	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS31315	COG2814	Major facilitator Superfamily
K562_RS31320	COG1022	Amp-dependent synthetase and ligase
K562_RS31320	COG3320	Male sterility
K562_RS31325	COG1012	belongs to the aldehyde dehydrogenase family
K562_RS31330	COG1024	Enoyl-CoA hydratase
K562_RS31385	COG2186	Transcriptional regulator
K562_RS31390	COG1609	Transcriptional regulator
K562_RS31410	COG1175	transmembrane transport
K562_RS31415	COG0395	ABC-type sugar transport system, permease component
K562_RS31425	COG0583	DNA-binding transcription factor activity
K562_RS31435	COG0513	Belongs to the DEAD box helicase family
K562_RS31440	COG2070	2-Nitropropane dioxygenase
K562_RS31445	COG2186	Transcriptional regulator
K562_RS31450	COG0277	FAD linked oxidase domain protein
K562_RS31455	COG0277	FAD linked oxidase domain protein
K562_RS31460	COG0247	lactate metabolic process
K562_RS31465	COG3193	protein, possibly involved in utilization of glycolate and propanediol
K562_RS31470	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
K562_RS31475	COG5001	Diguanylate cyclase
K562_RS31475	COG4251	negative regulation of phosphorylation
K562_RS31475	COG3706	GGDEF domain
K562_RS31475	COG2203	Gaf domain
K562_RS31485	COG2197	response regulator
K562_RS31490	COG0477	Major facilitator Superfamily
K562_RS31520	COG1657	PFAM Prenyltransferase squalene oxidase
K562_RS31525	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
K562_RS31530	COG1562	ergosterol biosynthetic process
K562_RS31555	COG3437	response regulator, receiver
K562_RS31575	COG1475	DNA binding
K562_RS31580	COG1192	Involved in chromosome partitioning
K562_RS31590	COG4977	sequence-specific DNA binding
K562_RS31660	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
K562_RS31665	COG1960	acyl-CoA dehydrogenase activity
K562_RS31680	COG2301	Belongs to the HpcH HpaI aldolase family
K562_RS31685	COG1725	Transcriptional regulator
K562_RS31690	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
K562_RS31695	COG2423	ornithine cyclodeaminase activity
K562_RS31700	COG0006	proline dipeptidase activity
K562_RS31705	COG3608	succinylglutamate desuccinylase aspartoacylase
K562_RS31710	COG1522	sequence-specific DNA binding
K562_RS31715	COG1012	belongs to the aldehyde dehydrogenase family
K562_RS31720	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K562_RS31730	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K562_RS31735	COG0477	Major facilitator Superfamily
K562_RS31740	COG0583	DNA-binding transcription factor activity
K562_RS31745	COG2814	Major facilitator Superfamily
K562_RS31750	COG3618	amidohydrolase
K562_RS31760	COG0477	Major facilitator Superfamily
K562_RS31765	COG1509	lysine 2,3-aminomutase activity
K562_RS31770	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K562_RS31780	COG0151	Belongs to the GarS family
K562_RS31785	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K562_RS31785	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
K562_RS31790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K562_RS31815	COG2376	Dihydroxyacetone kinase
K562_RS31820	COG3829	transcription factor binding
K562_RS31835	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K562_RS31840	COG1280	lysine exporter protein (LysE YggA)
K562_RS31845	COG0583	DNA-binding transcription factor activity
K562_RS31850	COG0583	DNA-binding transcription factor activity
K562_RS31855	COG0277	FAD linked oxidase domain protein
K562_RS31855	COG0247	lactate metabolic process
K562_RS31870	COG0697	spore germination
K562_RS31895	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS31910	COG4566	intracellular signal transduction
K562_RS31915	COG4191	Histidine kinase
K562_RS31930	COG0596	Alpha beta hydrolase
K562_RS31970	COG1132	(ABC) transporter
K562_RS31980	COG1309	transcriptional regulator
K562_RS31985	COG1309	transcriptional regulator
K562_RS31990	COG1764	response to oxidative stress
K562_RS32000	COG1380	Effector of murein hydrolase LrgA
K562_RS32005	COG1346	cytolysis
K562_RS32015	COG0655	NAD(P)H dehydrogenase (quinone) activity
K562_RS32020	COG1741	Belongs to the pirin family
K562_RS32025	COG0583	DNA-binding transcription factor activity
K562_RS32040	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
K562_RS32045	COG1228	amidohydrolase
K562_RS32055	COG1138	Cytochrome C-type biogenesis protein
K562_RS32065	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K562_RS32070	COG2271	Major facilitator Superfamily
K562_RS32090	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
K562_RS32110	COG0583	DNA-binding transcription factor activity
K562_RS32145	COG2986	histidine ammonia-lyase
K562_RS32170	COG2814	Major facilitator Superfamily
K562_RS32185	COG2271	Major facilitator Superfamily
K562_RS32190	COG1414	Transcriptional regulator
K562_RS32240	COG0010	Belongs to the arginase family
K562_RS32245	COG2271	Major facilitator Superfamily
K562_RS32260	COG0531	amino acid
K562_RS32265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
K562_RS32275	COG1802	Transcriptional regulator
K562_RS32290	COG4177	L-phenylalanine transmembrane transporter activity
K562_RS32320	COG3537	Alpha-1,2-mannosidase
K562_RS32335	COG2267	carboxylic ester hydrolase activity
K562_RS32380	COG0583	DNA-binding transcription factor activity
K562_RS32410	COG1657	PFAM Prenyltransferase squalene oxidase
K562_RS32435	COG4221	oxidoreductase activity
K562_RS32440	COG1942	4-Oxalocrotonate Tautomerase
K562_RS32455	COG0583	DNA-binding transcription factor activity
K562_RS32470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
K562_RS32480	COG0840	transmembrane signaling receptor activity
K562_RS32495	COG3268	Saccharopine dehydrogenase
K562_RS32500	COG0583	DNA-binding transcription factor activity
K562_RS32570	COG5434	Belongs to the glycosyl hydrolase 28 family
K562_RS32575	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
K562_RS32580	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
K562_RS32620	COG2226	methyltransferase
K562_RS32630	COG1960	acyl-CoA dehydrogenase activity
K562_RS32645	COG1960	acyl-CoA dehydrogenase activity
K562_RS32655	COG0318	PFAM AMP-dependent synthetase and ligase
K562_RS32705	COG4591	ABC-type transport system involved in lipoprotein release permease component
K562_RS32710	COG1136	(ABC) transporter
K562_RS32710	COG0577	efflux transmembrane transporter activity
K562_RS32730	COG0583	DNA-binding transcription factor activity
K562_RS32735	COG2267	carboxylic ester hydrolase activity
K562_RS32750	COG1879	ABC-type sugar transport system periplasmic component
K562_RS32755	COG1129	ABC transporter
K562_RS32760	COG1172	Belongs to the binding-protein-dependent transport system permease family
K562_RS32765	COG1172	Belongs to the binding-protein-dependent transport system permease family
K562_RS32775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K562_RS32775	COG2205	protein histidine kinase activity
K562_RS32790	COG5295	Hep Hag repeat protein
K562_RS32795	COG2885	chlorophyll binding
K562_RS32810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
K562_RS32820	COG1301	dicarboxylic acid transport
K562_RS32895	COG0583	DNA-binding transcription factor activity
K562_RS32900	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS32905	COG2153	protein acetylation
K562_RS32915	COG1301	dicarboxylic acid transport
K562_RS32945	COG2205	protein histidine kinase activity
K562_RS32950	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
K562_RS32970	COG4770	biotin carboxylase activity
K562_RS32980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K562_RS32985	COG1116	anion transmembrane transporter activity
K562_RS33000	COG0473	3-isopropylmalate dehydrogenase activity
K562_RS33015	COG2084	Dehydrogenase
K562_RS33025	COG0583	DNA-binding transcription factor activity
K562_RS33060	COG2175	clavaminate synthase activity
K562_RS33065	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
K562_RS33085	COG0463	Glycosyl transferase, family 2
K562_RS33130	COG4964	Belongs to the GSP D family
K562_RS33180	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
K562_RS33225	COG1609	Transcriptional regulator
K562_RS33230	COG3842	ATPase activity
K562_RS33240	COG1175	transmembrane transport
K562_RS33245	COG0395	ABC-type sugar transport system, permease component
K562_RS33255	COG2814	Major facilitator Superfamily
K562_RS33275	COG4774	siderophore transport
K562_RS33280	COG0745	RESPONSE REGULATOR receiver
K562_RS33315	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K562_RS33320	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K562_RS33325	COG0477	Major facilitator Superfamily
K562_RS33345	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K562_RS33350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K562_RS33370	COG2207	Transcriptional regulator
K562_RS33375	COG2017	converts alpha-aldose to the beta-anomer
K562_RS33380	COG1609	Transcriptional regulator
K562_RS33380	COG2207	Transcriptional regulator
K562_RS33385	COG2115	Belongs to the xylose isomerase family
K562_RS33390	COG4213	ABC transporter substrate-binding protein
K562_RS33400	COG4214	carbohydrate transport
K562_RS33420	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
K562_RS33425	COG0346	lactoylglutathione lyase activity
K562_RS33435	COG1804	L-carnitine dehydratase bile acid-inducible protein F
K562_RS33440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
K562_RS33460	COG0583	DNA-binding transcription factor activity
K562_RS33470	COG0129	dihydroxy-acid dehydratase activity
K562_RS33475	COG1609	Transcriptional regulator
K562_RS33500	COG2909	trisaccharide binding
K562_RS33505	COG0477	Major facilitator Superfamily
K562_RS33515	COG1012	belongs to the aldehyde dehydrogenase family
K562_RS33520	COG1522	sequence-specific DNA binding
K562_RS33530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
K562_RS33555	COG0601	transmembrane transport
K562_RS33560	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
K562_RS33570	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K562_RS33585	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
K562_RS33595	COG1473	amidohydrolase
K562_RS33615	COG1301	dicarboxylic acid transport
K562_RS33620	COG0583	DNA-binding transcription factor activity
K562_RS33680	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
K562_RS33685	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
K562_RS33695	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
K562_RS33705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
K562_RS33720	COG2175	clavaminate synthase activity
K562_RS33725	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS33745	COG0517	IMP dehydrogenase activity
K562_RS33750	COG1285	pathogenesis
K562_RS33755	COG1396	sequence-specific DNA binding
K562_RS33760	COG3550	peptidyl-serine autophosphorylation
K562_RS33785	COG1172	Belongs to the binding-protein-dependent transport system permease family
K562_RS33790	COG1129	ABC transporter
K562_RS33815	COG0765	amino acid transport
K562_RS33820	COG0765	amino acid transport
K562_RS33855	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K562_RS33860	COG1538	Outer membrane efflux protein
K562_RS33895	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K562_RS33900	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K562_RS33910	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
K562_RS33915	COG0738	Major facilitator superfamily
K562_RS33925	COG1349	DNA-binding transcription factor activity
K562_RS33930	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
K562_RS33955	COG2207	Transcriptional regulator
K562_RS33975	COG1250	3-hydroxyacyl-CoA dehydrogenase
K562_RS33980	COG0183	Belongs to the thiolase family
K562_RS33990	COG1960	acyl-CoA dehydrogenase activity
K562_RS34025	COG4753	response regulator
K562_RS34025	COG2207	Transcriptional regulator
K562_RS34030	COG2205	protein histidine kinase activity
K562_RS34035	COG0745	RESPONSE REGULATOR receiver
K562_RS34090	COG2201	protein-glutamate methylesterase activity
K562_RS34105	COG1914	H( )-stimulated, divalent metal cation uptake system
K562_RS34110	COG3546	catalase activity
K562_RS34225	COG3436	PFAM IS66 Orf2 family protein
K562_RS34235	COG2916	Histone family protein nucleoid-structuring protein H-NS
K562_RS34410	COG1380	Effector of murein hydrolase LrgA
K562_RS34415	COG1346	cytolysis
K562_RS34420	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
K562_RS34450	COG0778	Nitroreductase
K562_RS34455	COG0697	spore germination
K562_RS34465	COG4221	oxidoreductase activity
K562_RS34470	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
K562_RS34480	COG2271	Major facilitator Superfamily
K562_RS34485	COG4566	intracellular signal transduction
K562_RS34490	COG4191	Histidine kinase
K562_RS34500	COG0583	DNA-binding transcription factor activity
K562_RS34510	COG1522	sequence-specific DNA binding
K562_RS34515	COG1028	Short-chain dehydrogenase reductase Sdr
K562_RS34565	COG4804	nuclease activity
K562_RS34570	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K562_RS34580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
K562_RS34595	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
K562_RS34600	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
K562_RS34610	COG1953	Uracil, thiamine, allantoin
K562_RS34620	COG0493	'glutamate synthase
K562_RS34630	COG1309	transcriptional regulator
K562_RS34635	COG0183	Belongs to the thiolase family
K562_RS34645	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
K562_RS34725	COG0420	3'-5' exonuclease activity
K562_RS34740	COG0405	Gamma-glutamyltransferase
K562_RS34745	COG0583	DNA-binding transcription factor activity
K562_RS34755	COG2233	PERMEase
K562_RS34790	COG4977	sequence-specific DNA binding
K562_RS34810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
K562_RS34815	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
K562_RS34820	COG0583	DNA-binding transcription factor activity
K562_RS34830	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
K562_RS34840	COG0583	DNA-binding transcription factor activity
K562_RS34850	COG0583	DNA-binding transcription factor activity
K562_RS34880	COG0587	DNA-directed DNA polymerase activity
K562_RS34895	COG3344	reverse transcriptase
K562_RS35045	COG2186	Transcriptional regulator
K562_RS35090	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
K562_RS35135	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
K562_RS35215	COG1475	DNA binding
K562_RS35285	COG2192	nodulation
K562_RS35290	COG0812	UDP-N-acetylmuramate dehydrogenase activity
K562_RS35305	COG3012	SEC-C Motif Domain Protein
K562_RS35320	COG1487	ribonuclease activity
K562_RS35325	COG4456	Virulence-associated protein