locus-tag	class	description
DM42_RS00065	COG4566	intracellular signal transduction
DM42_RS00450	COG0840	transmembrane signaling receptor activity
DM42_RS00460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DM42_RS01190	COG0210	DNA helicase
DM42_RS01205	COG0525	valine-tRNA ligase activity
DM42_RS01225	COG5002	protein histidine kinase activity
DM42_RS01530	COG1215	transferase activity, transferring glycosyl groups
DM42_RS01575	COG1215	transferase activity, transferring glycosyl groups
DM42_RS02320	COG1840	ABC-type Fe3 transport system, periplasmic component
DM42_RS02520	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM42_RS02735	COG2153	protein acetylation
DM42_RS03185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DM42_RS03400	COG0564	pseudouridine synthase activity
DM42_RS03710	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DM42_RS04000	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DM42_RS04130	COG1674	ftsk spoiiie
DM42_RS04180	COG2814	Major facilitator Superfamily
DM42_RS04465	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DM42_RS04485	COG0662	Cupin 2, conserved barrel domain protein
DM42_RS04485	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DM42_RS04850	COG0604	alcohol dehydrogenase
DM42_RS04850	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS04850	COG3321	synthase
DM42_RS04925	COG0438	transferase activity, transferring glycosyl groups
DM42_RS04925	COG1216	Glycosyl transferase, family 2
DM42_RS04945	COG0438	transferase activity, transferring glycosyl groups
DM42_RS04945	COG1216	Glycosyl transferase, family 2
DM42_RS05495	COG0477	Major facilitator Superfamily
DM42_RS05555	COG1129	ABC transporter
DM42_RS06055	COG1187	pseudouridine synthase activity
DM42_RS06145	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DM42_RS06585	COG2267	carboxylic ester hydrolase activity
DM42_RS07145	COG1388	LysM domain
DM42_RS07145	COG0741	lytic transglycosylase activity
DM42_RS07230	COG1250	3-hydroxyacyl-CoA dehydrogenase
DM42_RS07450	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DM42_RS07460	COG1074	ATP-dependent DNA helicase activity
DM42_RS07475	COG1074	ATP-dependent DNA helicase activity
DM42_RS07490	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DM42_RS07745	COG3300	MHYT domain
DM42_RS07745	COG5001	Diguanylate cyclase
DM42_RS08145	COG0210	DNA helicase
DM42_RS08545	COG1530	ribonuclease E activity
DM42_RS08685	COG0312	modulator of DNA gyrase
DM42_RS08775	COG0123	including yeast histone deacetylase and acetoin utilization protein
DM42_RS08825	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DM42_RS08930	COG3383	formate dehydrogenase (NAD+) activity
DM42_RS09210	COG1674	ftsk spoiiie
DM42_RS09460	COG3842	ATPase activity
DM42_RS09485	COG0804	urea catabolic process
DM42_RS10335	COG0512	Glutamine amidotransferase of anthranilate synthase
DM42_RS10335	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DM42_RS10355	COG0443	Heat shock 70 kDa protein
DM42_RS10380	COG1420	regulation of RNA biosynthetic process
DM42_RS10470	COG0277	FAD linked oxidase domain protein
DM42_RS10485	COG0247	lactate metabolic process
DM42_RS10515	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DM42_RS10540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DM42_RS10835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DM42_RS10935	COG1301	dicarboxylic acid transport
DM42_RS10995	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DM42_RS12020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DM42_RS12385	COG0085	RNA polymerase activity
DM42_RS13055	COG0582	viral genome integration into host DNA
DM42_RS13310	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DM42_RS13315	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DM42_RS13330	COG0318	PFAM AMP-dependent synthetase and ligase
DM42_RS13625	COG1846	Transcriptional regulator
DM42_RS13745	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DM42_RS14375	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DM42_RS14375	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DM42_RS14415	COG0768	penicillin binding
DM42_RS14725	COG0444	Belongs to the ABC transporter superfamily
DM42_RS15325	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DM42_RS15405	COG0025	NhaP-type Na H and K H
DM42_RS15530	COG0018	arginyl-trna synthetase
DM42_RS15715	COG1960	acyl-CoA dehydrogenase activity
DM42_RS15840	COG2226	methyltransferase
DM42_RS15950	COG0587	DNA-directed DNA polymerase activity
DM42_RS16035	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DM42_RS16495	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DM42_RS16535	COG1702	phosphate starvation-inducible protein PhoH
DM42_RS17010	COG2814	Major facilitator Superfamily
DM42_RS17255	COG0542	response to heat
DM42_RS17435	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS17645	COG0489	protein tyrosine kinase activity
DM42_RS17745	COG0181	hydroxymethylbilane synthase activity
DM42_RS18055	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DM42_RS19100	COG1546	Belongs to the CinA family
DM42_RS19100	COG1058	Belongs to the CinA family
DM42_RS19225	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DM42_RS19315	COG1176	ABC-type spermidine putrescine transport system, permease component I
DM42_RS19320	COG3842	ATPase activity
DM42_RS19340	COG3246	L-lysine catabolic process to acetate
DM42_RS19345	COG2175	clavaminate synthase activity
DM42_RS19360	COG2909	trisaccharide binding
DM42_RS19370	COG0625	glutathione transferase activity
DM42_RS19375	COG1846	Transcriptional regulator
DM42_RS19380	COG2807	transmembrane transport
DM42_RS19390	COG2099	Precorrin-6x reductase
DM42_RS19395	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
DM42_RS19425	COG3979	chitinase
DM42_RS19440	COG2851	Citrate transporter
DM42_RS19445	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DM42_RS19455	COG0494	nUDIX hydrolase
DM42_RS19470	COG1671	Belongs to the UPF0178 family
DM42_RS19525	COG3609	addiction module antidote protein, CC2985 family
DM42_RS19530	COG1473	amidohydrolase
DM42_RS19545	COG4774	siderophore transport
DM42_RS19550	COG3486	L-lysine 6-monooxygenase (NADPH) activity
DM42_RS19590	COG1120	ATPase activity
DM42_RS19595	COG2175	clavaminate synthase activity
DM42_RS19645	COG3121	Chaperone
DM42_RS19650	COG3188	usher protein
DM42_RS19665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM42_RS19675	COG1309	transcriptional regulator
DM42_RS19680	COG0739	heme binding
DM42_RS19685	COG0765	amino acid transport
DM42_RS19690	COG0765	amino acid transport
DM42_RS19695	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM42_RS19700	COG0477	Major facilitator Superfamily
DM42_RS19705	COG2719	SpoVR family
DM42_RS19710	COG2718	Belongs to the UPF0229 family
DM42_RS19715	COG2766	serine protein kinase
DM42_RS19720	COG0840	transmembrane signaling receptor activity
DM42_RS19725	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DM42_RS19730	COG1609	Transcriptional regulator
DM42_RS19735	COG1172	Belongs to the binding-protein-dependent transport system permease family
DM42_RS19740	COG1129	ABC transporter
DM42_RS19745	COG1879	ABC-type sugar transport system periplasmic component
DM42_RS19750	COG0583	DNA-binding transcription factor activity
DM42_RS19755	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
DM42_RS19760	COG4208	sulfate ABC transporter
DM42_RS19765	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
DM42_RS19770	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
DM42_RS19775	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
DM42_RS19810	COG0701	Predicted permease
DM42_RS19815	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
DM42_RS19820	COG0583	DNA-binding transcription factor activity
DM42_RS19835	COG0667	Aldo Keto reductase
DM42_RS19905	COG0456	acetyltransferase
DM42_RS19920	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DM42_RS19945	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM42_RS19970	COG4702	Belongs to the UPF0303 family
DM42_RS19985	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DM42_RS19990	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
DM42_RS19995	COG0167	dihydroorotate dehydrogenase activity
DM42_RS20000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM42_RS20005	COG0765	amino acid transport
DM42_RS20015	COG1802	Transcriptional regulator
DM42_RS20020	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
DM42_RS20025	COG3023	N-Acetylmuramoyl-L-alanine amidase
DM42_RS20030	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DM42_RS20035	COG0557	exoribonuclease II activity
DM42_RS20045	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
DM42_RS20055	COG1940	carbohydrate kinase activity
DM42_RS20065	COG1172	Belongs to the binding-protein-dependent transport system permease family
DM42_RS20070	COG1879	ABC-type sugar transport system periplasmic component
DM42_RS20095	COG2814	Major facilitator Superfamily
DM42_RS20105	COG0318	PFAM AMP-dependent synthetase and ligase
DM42_RS20170	COG4964	Belongs to the GSP D family
DM42_RS20220	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
DM42_RS20225	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DM42_RS20230	COG0508	dehydrogenase complex catalyzes the overall conversion of
DM42_RS20235	COG0567	Dehydrogenase, E1 component
DM42_RS20240	COG1217	gtp-binding protein TYPA
DM42_RS20245	COG1846	Transcriptional regulator
DM42_RS20255	COG1566	PFAM secretion protein HlyD family protein
DM42_RS20260	COG2814	Major facilitator Superfamily
DM42_RS20280	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
DM42_RS20285	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
DM42_RS20290	COG2251	uridine kinase activity
DM42_RS20290	COG0195	Participates in both transcription termination and antitermination
DM42_RS20295	COG0779	Required for maturation of 30S ribosomal subunits
DM42_RS20305	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
DM42_RS20310	COG0436	Aminotransferase
DM42_RS20315	COG0583	DNA-binding transcription factor activity
DM42_RS20355	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
DM42_RS20370	COG2365	Tyrosine phosphatase family
DM42_RS20385	COG0776	regulation of translation
DM42_RS20395	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DM42_RS20410	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DM42_RS20415	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
DM42_RS20425	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DM42_RS20430	COG0251	oxidation-reduction process
DM42_RS20440	COG0583	DNA-binding transcription factor activity
DM42_RS20455	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS20480	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS20490	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
DM42_RS20495	COG0477	Major facilitator Superfamily
DM42_RS20510	COG1295	ribonuclease BN
DM42_RS20525	COG0277	FAD linked oxidase domain protein
DM42_RS20535	COG0583	DNA-binding transcription factor activity
DM42_RS20560	COG0840	transmembrane signaling receptor activity
DM42_RS20565	COG2223	nitrite transmembrane transporter activity
DM42_RS20570	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DM42_RS20575	COG0210	DNA helicase
DM42_RS20580	COG0525	valine-tRNA ligase activity
DM42_RS20585	COG1210	Utp--glucose-1-phosphate uridylyltransferase
DM42_RS20595	COG5002	protein histidine kinase activity
DM42_RS20605	COG0745	RESPONSE REGULATOR receiver
DM42_RS20615	COG0425	Belongs to the sulfur carrier protein TusA family
DM42_RS20630	COG1737	Transcriptional regulator
DM42_RS20635	COG0673	inositol 2-dehydrogenase activity
DM42_RS20650	COG1082	Xylose isomerase domain protein TIM barrel
DM42_RS20655	COG1172	Belongs to the binding-protein-dependent transport system permease family
DM42_RS20670	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DM42_RS20675	COG3962	Belongs to the TPP enzyme family
DM42_RS20685	COG3718	enzyme involved in inositol metabolism
DM42_RS20690	COG4702	Belongs to the UPF0303 family
DM42_RS20695	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS20720	COG0824	Thioesterase
DM42_RS20725	COG0494	nUDIX hydrolase
DM42_RS20730	COG0477	Major facilitator Superfamily
DM42_RS20740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DM42_RS20745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DM42_RS20760	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DM42_RS20765	COG0494	nUDIX hydrolase
DM42_RS20775	COG1858	cytochrome C peroxidase
DM42_RS20815	COG0583	DNA-binding transcription factor activity
DM42_RS20830	COG0025	NhaP-type Na H and K H
DM42_RS20840	COG1741	Belongs to the pirin family
DM42_RS20850	COG2194	sulfuric ester hydrolase activity
DM42_RS20880	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
DM42_RS20885	COG1215	transferase activity, transferring glycosyl groups
DM42_RS20900	COG2453	phosphatase
DM42_RS20900	COG0671	phosphoesterase, PA-phosphatase related
DM42_RS20905	COG2267	carboxylic ester hydrolase activity
DM42_RS20910	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DM42_RS20920	COG4589	Belongs to the CDS family
DM42_RS20930	COG2197	response regulator
DM42_RS20950	COG2851	Citrate transporter
DM42_RS20955	COG0583	DNA-binding transcription factor activity
DM42_RS20960	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DM42_RS20970	COG0583	DNA-binding transcription factor activity
DM42_RS20980	COG4774	siderophore transport
DM42_RS20985	COG3712	iron ion homeostasis
DM42_RS20990	COG1595	DNA-templated transcription, initiation
DM42_RS20995	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM42_RS21085	COG0745	RESPONSE REGULATOR receiver
DM42_RS21090	COG2205	protein histidine kinase activity
DM42_RS21095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DM42_RS21105	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DM42_RS21110	COG4774	siderophore transport
DM42_RS21125	COG3485	protocatechuate 3,4-dioxygenase
DM42_RS21140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DM42_RS21155	COG0446	pyridine nucleotide-disulphide oxidoreductase
DM42_RS21155	COG1902	pentaerythritol trinitrate reductase activity
DM42_RS21160	COG1695	Transcriptional regulator
DM42_RS21170	COG1960	acyl-CoA dehydrogenase activity
DM42_RS21175	COG0235	Class ii aldolase
DM42_RS21200	COG1215	transferase activity, transferring glycosyl groups
DM42_RS21230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DM42_RS21245	COG3707	response regulator
DM42_RS21305	COG0582	viral genome integration into host DNA
DM42_RS21325	COG4942	peptidase
DM42_RS21330	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
DM42_RS21340	COG0534	Mate efflux family protein
DM42_RS21385	COG0745	RESPONSE REGULATOR receiver
DM42_RS21400	COG0581	inorganic phosphate transmembrane transporter activity
DM42_RS21405	COG0573	inorganic phosphate transmembrane transporter activity
DM42_RS21410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DM42_RS21415	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
DM42_RS21425	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DM42_RS21435	COG1534	Rna-binding protein
DM42_RS21445	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
DM42_RS21450	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DM42_RS21460	COG0505	Belongs to the CarA family
DM42_RS21465	COG2223	nitrite transmembrane transporter activity
DM42_RS21470	COG1388	LysM domain
DM42_RS21470	COG0741	lytic transglycosylase activity
DM42_RS21475	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DM42_RS21480	COG2226	methyltransferase
DM42_RS21485	COG0328	RNA-DNA hybrid ribonuclease activity
DM42_RS21490	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
DM42_RS21535	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
DM42_RS21555	COG3052	prosthetic group binding
DM42_RS21575	COG0583	DNA-binding transcription factor activity
DM42_RS21585	COG1250	3-hydroxyacyl-CoA dehydrogenase
DM42_RS21605	COG1253	flavin adenine dinucleotide binding
DM42_RS21610	COG0583	DNA-binding transcription factor activity
DM42_RS21625	COG0583	DNA-binding transcription factor activity
DM42_RS21630	COG2814	Major facilitator Superfamily
DM42_RS21645	COG0477	Major facilitator Superfamily
DM42_RS21650	COG0583	DNA-binding transcription factor activity
DM42_RS21655	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM42_RS21660	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
DM42_RS21665	COG0456	acetyltransferase
DM42_RS21670	COG0010	Belongs to the arginase family
DM42_RS21680	COG0702	epimerase
DM42_RS21695	COG0022	dehydrogenase e1 component
DM42_RS21705	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DM42_RS21710	COG0583	DNA-binding transcription factor activity
DM42_RS21715	COG1902	pentaerythritol trinitrate reductase activity
DM42_RS21720	COG2259	Doxx family
DM42_RS21730	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS21735	COG1609	Transcriptional regulator
DM42_RS21740	COG1840	ABC-type Fe3 transport system, periplasmic component
DM42_RS21750	COG1177	transmembrane transport
DM42_RS21755	COG3842	ATPase activity
DM42_RS21760	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
DM42_RS21765	COG2814	Major facilitator Superfamily
DM42_RS21770	COG0697	spore germination
DM42_RS21785	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DM42_RS21790	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
DM42_RS21800	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DM42_RS21815	COG0697	spore germination
DM42_RS21825	COG2200	EAL domain
DM42_RS21835	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DM42_RS21840	COG1074	ATP-dependent DNA helicase activity
DM42_RS21845	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
DM42_RS21850	COG1289	transmembrane transporter activity
DM42_RS21860	COG1840	ABC-type Fe3 transport system, periplasmic component
DM42_RS21865	COG1178	ABC-type Fe3 transport system permease component
DM42_RS21870	COG3842	ATPase activity
DM42_RS21875	COG1522	sequence-specific DNA binding
DM42_RS21885	COG1959	2 iron, 2 sulfur cluster binding
DM42_RS21900	COG0004	ammonium transporteR
DM42_RS21915	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DM42_RS21925	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM42_RS21940	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM42_RS21970	COG0450	alkyl hydroperoxide reductase
DM42_RS21990	COG2988	succinylglutamate desuccinylase activity
DM42_RS21995	COG3724	N-succinylarginine dihydrolase activity
DM42_RS22000	COG1012	belongs to the aldehyde dehydrogenase family
DM42_RS22015	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DM42_RS22020	COG3328	transposase activity
DM42_RS22055	COG3394	polysaccharide catabolic process
DM42_RS22060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DM42_RS22070	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
DM42_RS22075	COG0596	Alpha beta hydrolase
DM42_RS22085	COG3511	phospholipase C
DM42_RS22115	COG0438	transferase activity, transferring glycosyl groups
DM42_RS22120	COG1132	(ABC) transporter
DM42_RS22125	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
DM42_RS22135	COG1999	signal sequence binding
DM42_RS22150	COG2153	protein acetylation
DM42_RS22165	COG1956	GAF domain-containing protein
DM42_RS22170	COG0024	Methionine aminopeptidase
DM42_RS22190	COG0596	Alpha beta hydrolase
DM42_RS22195	COG2203	Gaf domain
DM42_RS22195	COG4251	negative regulation of phosphorylation
DM42_RS22195	COG3706	GGDEF domain
DM42_RS22195	COG5001	Diguanylate cyclase
DM42_RS22260	COG0629	single-stranded DNA binding
DM42_RS22265	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DM42_RS22280	COG0789	Transcriptional regulator
DM42_RS22290	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DM42_RS22330	COG0789	Transcriptional regulator
DM42_RS22425	COG0210	DNA helicase
DM42_RS22545	COG2003	Belongs to the UPF0758 family
DM42_RS22600	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DM42_RS22600	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DM42_RS22605	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DM42_RS22610	COG1252	NADH dehydrogenase
DM42_RS22615	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DM42_RS22680	COG0583	DNA-binding transcription factor activity
DM42_RS22690	COG2837	iron assimilation
DM42_RS22695	COG0582	viral genome integration into host DNA
DM42_RS22725	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DM42_RS22735	COG1472	Belongs to the glycosyl hydrolase 3 family
DM42_RS22755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DM42_RS22760	COG0571	ribonuclease III activity
DM42_RS22765	COG0681	Belongs to the peptidase S26 family
DM42_RS22780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DM42_RS22795	COG1595	DNA-templated transcription, initiation
DM42_RS22805	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DM42_RS22815	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS22840	COG1399	metal-binding, possibly nucleic acid-binding protein
DM42_RS22855	COG0616	signal peptide processing
DM42_RS22865	COG0546	phosphoglycolate phosphatase activity
DM42_RS22875	COG1530	ribonuclease E activity
DM42_RS22880	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DM42_RS22890	COG0303	'Molybdopterin
DM42_RS22930	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
DM42_RS22945	COG3045	CreA protein
DM42_RS22975	COG2501	S4 domain
DM42_RS22985	COG0114	fumarate hydratase activity
DM42_RS23005	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
DM42_RS23010	COG2204	response regulator
DM42_RS23025	COG0312	modulator of DNA gyrase
DM42_RS23030	COG3028	Belongs to the UPF0307 family
DM42_RS23035	COG0521	Mo-molybdopterin cofactor biosynthetic process
DM42_RS23045	COG0501	Belongs to the peptidase M48B family
DM42_RS23065	COG0494	nUDIX hydrolase
DM42_RS23075	COG0336	Belongs to the RNA methyltransferase TrmD family
DM42_RS23110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DM42_RS23130	COG2011	ABC-type metal ion transport system permease component
DM42_RS23140	COG2267	carboxylic ester hydrolase activity
DM42_RS23145	COG0123	including yeast histone deacetylase and acetoin utilization protein
DM42_RS23150	COG2951	lytic endotransglycosylase activity
DM42_RS23170	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
DM42_RS23180	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
DM42_RS23190	COG0776	regulation of translation
DM42_RS23200	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
DM42_RS23205	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
DM42_RS23210	COG0287	Prephenate dehydrogenase
DM42_RS23240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
DM42_RS23245	COG0546	phosphoglycolate phosphatase activity
DM42_RS23255	COG4584	PFAM Integrase catalytic
DM42_RS23260	COG1484	DNA-dependent DNA replication
DM42_RS23270	COG1910	domain protein
DM42_RS23285	COG3383	formate dehydrogenase (NAD+) activity
DM42_RS23320	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DM42_RS23330	COG0154	amidase activity
DM42_RS23345	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
DM42_RS23355	COG0402	S-adenosylhomocysteine deaminase activity
DM42_RS23360	COG2119	membrane
DM42_RS23370	COG0308	aminopeptidase N
DM42_RS23375	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DM42_RS23415	COG4772	TonB-dependent receptor
DM42_RS23440	COG1278	Cold shock
DM42_RS23450	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM42_RS23475	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DM42_RS23490	COG1561	YicC-like family, N-terminal region
DM42_RS23495	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
DM42_RS23500	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
DM42_RS23505	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DM42_RS23550	COG0477	Major facilitator Superfamily
DM42_RS23560	COG0859	PFAM glycosyl transferase family 9
DM42_RS23580	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
DM42_RS23585	COG2894	cell division
DM42_RS23590	COG0850	regulation of cytokinetic process
DM42_RS23610	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
DM42_RS23620	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DM42_RS23625	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DM42_RS23630	COG1674	ftsk spoiiie
DM42_RS23635	COG0492	ferredoxin-NADP+ reductase activity
DM42_RS23640	COG1193	negative regulation of DNA recombination
DM42_RS23645	COG2860	membrane
DM42_RS23650	COG3842	ATPase activity
DM42_RS23655	COG0395	ABC-type sugar transport system, permease component
DM42_RS23660	COG1175	transmembrane transport
DM42_RS23670	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
DM42_RS23675	COG0363	glucosamine-6-phosphate deaminase activity
DM42_RS23685	COG2814	Major facilitator Superfamily
DM42_RS23695	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DM42_RS23700	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DM42_RS23700	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DM42_RS23730	COG0436	Aminotransferase
DM42_RS23760	COG0762	integral membrane protein
DM42_RS23770	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DM42_RS23775	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
DM42_RS23785	COG0494	nUDIX hydrolase
DM42_RS23795	COG1024	Enoyl-CoA hydratase
DM42_RS23800	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DM42_RS23805	COG2814	Major facilitator Superfamily
DM42_RS23810	COG0583	DNA-binding transcription factor activity
DM42_RS23820	COG4948	Mandelate Racemase Muconate Lactonizing
DM42_RS23865	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DM42_RS23875	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DM42_RS23895	COG0559	Belongs to the binding-protein-dependent transport system permease family
DM42_RS23905	COG1129	ABC transporter
DM42_RS23915	COG0829	nickel cation binding
DM42_RS23920	COG0831	urea catabolic process
DM42_RS23925	COG0832	Belongs to the urease beta subunit family
DM42_RS23930	COG0804	urea catabolic process
DM42_RS23980	COG0438	transferase activity, transferring glycosyl groups
DM42_RS23985	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DM42_RS24000	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DM42_RS24015	COG0662	Cupin 2, conserved barrel domain protein
DM42_RS24015	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
DM42_RS24030	COG0438	transferase activity, transferring glycosyl groups
DM42_RS24040	COG0297	glycogen (starch) synthase activity
DM42_RS24110	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
DM42_RS24120	COG1678	Uncharacterized ACR, COG1678
DM42_RS24130	COG1773	rubredoxin
DM42_RS24140	COG0459	protein refolding
DM42_RS24145	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DM42_RS24190	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DM42_RS24210	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
DM42_RS24220	COG0730	response to heat
DM42_RS24275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DM42_RS24295	COG4977	sequence-specific DNA binding
DM42_RS24300	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
DM42_RS24305	COG0583	DNA-binding transcription factor activity
DM42_RS24310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DM42_RS24315	COG0778	Nitroreductase
DM42_RS24320	COG2814	Major facilitator Superfamily
DM42_RS24340	COG2814	Major facilitator Superfamily
DM42_RS24370	COG1960	acyl-CoA dehydrogenase activity
DM42_RS24375	COG0450	alkyl hydroperoxide reductase
DM42_RS24400	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
DM42_RS24410	COG4221	oxidoreductase activity
DM42_RS24415	COG0824	Thioesterase
DM42_RS24435	COG0823	Involved in the tonB-independent uptake of proteins
DM42_RS24485	COG4682	membrane
DM42_RS24495	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DM42_RS24510	COG0529	Catalyzes the synthesis of activated sulfate
DM42_RS24520	COG0156	8-amino-7-oxononanoate synthase activity
DM42_RS24525	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DM42_RS24530	COG0604	alcohol dehydrogenase
DM42_RS24530	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS24530	COG3321	synthase
DM42_RS24540	COG4584	PFAM Integrase catalytic
DM42_RS24545	COG1484	DNA-dependent DNA replication
DM42_RS24555	COG0300	oxidoreductase activity
DM42_RS24660	COG0586	Pfam SNARE associated Golgi protein
DM42_RS24665	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
DM42_RS24690	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DM42_RS24695	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DM42_RS24705	COG0617	tRNA 3'-terminal CCA addition
DM42_RS24710	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DM42_RS24725	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
DM42_RS24725	COG0512	Glutamine amidotransferase of anthranilate synthase
DM42_RS24735	COG0443	Heat shock 70 kDa protein
DM42_RS24745	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DM42_RS24760	COG1420	regulation of RNA biosynthetic process
DM42_RS24765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
DM42_RS24770	COG0497	DNA recombination
DM42_RS24775	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
DM42_RS24785	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
DM42_RS24790	COG0312	modulator of DNA gyrase
DM42_RS24795	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
DM42_RS24810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DM42_RS24810	COG1017	nitric oxide dioxygenase activity
DM42_RS24815	COG2096	Adenosyltransferase
DM42_RS24820	COG0277	FAD linked oxidase domain protein
DM42_RS24825	COG0277	FAD linked oxidase domain protein
DM42_RS24830	COG0277	FAD linked oxidase domain protein
DM42_RS24835	COG0247	lactate metabolic process
DM42_RS24855	COG0783	Belongs to the Dps family
DM42_RS24860	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
DM42_RS24870	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DM42_RS24875	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
DM42_RS24880	COG0343	queuine tRNA-ribosyltransferase activity
DM42_RS24885	COG1862	Preprotein translocase
DM42_RS24890	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DM42_RS24895	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DM42_RS24900	COG0793	Belongs to the peptidase S41A family
DM42_RS24915	COG2353	YceI-like domain
DM42_RS24930	COG2995	paraquat-inducible protein a
DM42_RS24935	COG3008	intermembrane lipid transfer
DM42_RS24935	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DM42_RS24960	COG0640	Transcriptional regulator
DM42_RS25005	COG0482	sulfurtransferase activity
DM42_RS25010	COG0069	glutamate synthase activity
DM42_RS25015	COG0625	glutathione transferase activity
DM42_RS25020	COG0006	proline dipeptidase activity
DM42_RS25025	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DM42_RS25035	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
DM42_RS25040	COG0138	bifunctional purine biosynthesis protein purh
DM42_RS25050	COG0632	four-way junction helicase activity
DM42_RS25055	COG2255	four-way junction helicase activity
DM42_RS25070	COG0588	phosphoglycerate mutase activity
DM42_RS25075	COG1490	D-aminoacyl-tRNA deacylase activity
DM42_RS25085	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
DM42_RS25100	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DM42_RS25120	COG0418	dihydroorotase activity
DM42_RS25125	COG0121	glutamine amidotransferase
DM42_RS25135	COG1126	abc transporter atp-binding protein
DM42_RS25140	COG0765	amino acid transport
DM42_RS25145	COG0765	amino acid transport
DM42_RS25155	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
DM42_RS25160	COG0583	DNA-binding transcription factor activity
DM42_RS25170	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DM42_RS25180	COG3265	gluconokinase activity
DM42_RS25190	COG0800	Aldolase
DM42_RS25205	COG3344	reverse transcriptase
DM42_RS25210	COG1981	membrane
DM42_RS25215	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DM42_RS25220	COG1466	dna polymerase III delta subunit
DM42_RS25225	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
DM42_RS25230	COG0495	leucyl-tRNA aminoacylation
DM42_RS25245	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
DM42_RS25250	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DM42_RS25255	COG0735	belongs to the Fur family
DM42_RS25260	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
DM42_RS25265	COG4266	Belongs to the allantoicase family
DM42_RS25270	COG1301	dicarboxylic acid transport
DM42_RS25280	COG0583	DNA-binding transcription factor activity
DM42_RS25285	COG2814	Major facilitator Superfamily
DM42_RS25290	COG1063	alcohol dehydrogenase
DM42_RS25295	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS25300	COG0583	DNA-binding transcription factor activity
DM42_RS25305	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
DM42_RS25310	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DM42_RS25315	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
DM42_RS25325	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DM42_RS25335	COG4290	ribonuclease
DM42_RS25350	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DM42_RS25355	COG1546	Belongs to the CinA family
DM42_RS25365	COG0284	orotidine-5'-phosphate decarboxylase activity
DM42_RS25395	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS25400	COG0800	Aldolase
DM42_RS25405	COG3734	2-keto-3-deoxy-galactonokinase
DM42_RS25410	COG1414	Transcriptional regulator
DM42_RS25430	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DM42_RS25435	COG0557	exoribonuclease II activity
DM42_RS25440	COG3150	esterase
DM42_RS25445	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DM42_RS25455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DM42_RS25460	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DM42_RS25465	COG0511	ligase activity, forming carbon-carbon bonds
DM42_RS25470	COG0439	Biotin carboxylase
DM42_RS25485	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DM42_RS25490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DM42_RS25530	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DM42_RS25535	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
DM42_RS25540	COG2095	MarC family integral membrane protein
DM42_RS25545	COG0442	prolyl-tRNA aminoacylation
DM42_RS25550	COG0494	nUDIX hydrolase
DM42_RS25565	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
DM42_RS25580	COG0142	geranyltranstransferase activity
DM42_RS25590	COG4536	flavin adenine dinucleotide binding
DM42_RS25605	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
DM42_RS25615	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
DM42_RS25620	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
DM42_RS25625	COG0494	nUDIX hydrolase
DM42_RS25640	COG0653	protein targeting
DM42_RS25650	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
DM42_RS25660	COG0678	peroxiredoxin activity
DM42_RS25675	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
DM42_RS25680	COG1181	Belongs to the D-alanine--D-alanine ligase family
DM42_RS25685	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
DM42_RS25690	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
DM42_RS25710	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
DM42_RS25715	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DM42_RS25725	COG3116	cell division
DM42_RS25730	COG0275	rRNA processing
DM42_RS25735	COG2001	Belongs to the MraZ family
DM42_RS25740	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
DM42_RS25745	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM42_RS25750	COG0318	PFAM AMP-dependent synthetase and ligase
DM42_RS25755	COG0243	molybdopterin cofactor binding
DM42_RS25785	COG1024	Enoyl-CoA hydratase
DM42_RS25800	COG1024	Enoyl-CoA hydratase
DM42_RS25805	COG2050	protein possibly involved in aromatic compounds catabolism
DM42_RS25815	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
DM42_RS25820	COG2967	ApaG domain
DM42_RS25825	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DM42_RS25830	COG0546	phosphoglycolate phosphatase activity
DM42_RS25840	COG0512	Glutamine amidotransferase of anthranilate synthase
DM42_RS25845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DM42_RS25860	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DM42_RS25875	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DM42_RS25880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
DM42_RS25885	COG0012	GTP binding
DM42_RS25910	COG0583	DNA-binding transcription factor activity
DM42_RS25920	COG0488	(ABC) transporter
DM42_RS25930	COG1335	isochorismatase
DM42_RS25935	COG0006	proline dipeptidase activity
DM42_RS25950	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DM42_RS25955	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DM42_RS25960	COG2890	protein-(glutamine-N5) methyltransferase activity
DM42_RS25965	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
DM42_RS25975	COG3384	dioxygenase
DM42_RS25980	COG0531	amino acid
DM42_RS25985	COG1278	Cold shock
DM42_RS25990	COG0443	Heat shock 70 kDa protein
DM42_RS26005	COG1309	transcriptional regulator
DM42_RS26020	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
DM42_RS26025	COG3422	double-strand break repair
DM42_RS26035	COG0308	aminopeptidase N
DM42_RS26150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM42_RS26165	COG2969	positive regulation of protein catabolic process
DM42_RS26170	COG0625	glutathione transferase activity
DM42_RS26175	COG2857	Cytochrome c1
DM42_RS26180	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DM42_RS26185	COG0723	plastoquinol--plastocyanin reductase activity
DM42_RS26190	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DM42_RS26195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DM42_RS26200	COG0805	protein transport
DM42_RS26230	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DM42_RS26235	COG0107	imidazoleglycerol-phosphate synthase activity
DM42_RS26250	COG2095	MarC family integral membrane protein
DM42_RS26280	COG5007	Belongs to the BolA IbaG family
DM42_RS26285	COG0842	Transport permease protein
DM42_RS26290	COG1131	(ABC) transporter
DM42_RS26310	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DM42_RS26315	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DM42_RS26320	COG1127	ABC transporter
DM42_RS26345	COG4178	(ABC) transporter
DM42_RS26350	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS26355	COG2814	Major facilitator Superfamily
DM42_RS26360	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DM42_RS26370	COG1115	amino acid carrier protein
DM42_RS26380	COG0067	glutamate synthase
DM42_RS26380	COG0069	glutamate synthase activity
DM42_RS26380	COG0070	glutamate synthase
DM42_RS26395	COG0584	glycerophosphoryl diester phosphodiesterase
DM42_RS26405	COG0395	ABC-type sugar transport system, permease component
DM42_RS26410	COG1175	transmembrane transport
DM42_RS26415	COG1653	transport
DM42_RS26420	COG0232	Belongs to the dGTPase family. Type 2 subfamily
DM42_RS26425	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
DM42_RS26460	COG1965	Belongs to the frataxin family
DM42_RS26470	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
DM42_RS26475	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DM42_RS26480	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DM42_RS26485	COG1333	cytochrome c biogenesis protein
DM42_RS26505	COG4232	protein-disulfide reductase activity
DM42_RS26535	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
DM42_RS26550	COG0201	protein transport
DM42_RS26555	COG0200	Binds to the 23S rRNA
DM42_RS26565	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DM42_RS26660	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DM42_RS26680	COG0514	ATP-dependent DNA helicase (RecQ)
DM42_RS26685	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
DM42_RS26690	COG0085	RNA polymerase activity
DM42_RS26695	COG0222	ribosome binding
DM42_RS26700	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DM42_RS26705	COG0081	regulation of translation
DM42_RS26720	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DM42_RS26730	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DM42_RS26780	COG3396	Phenylacetate-CoA oxygenase
DM42_RS26785	COG3460	Phenylacetate-CoA oxygenase
DM42_RS26790	COG3396	Phenylacetate-CoA oxygenase
DM42_RS26795	COG2151	metal-sulfur cluster biosynthetic enzyme
DM42_RS26800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
DM42_RS26820	COG1522	sequence-specific DNA binding
DM42_RS26840	COG0280	phosphate acetyltransferase
DM42_RS26840	COG0281	malic enzyme
DM42_RS26845	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
DM42_RS26850	COG1881	PFAM PEBP family protein
DM42_RS26860	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
DM42_RS26875	COG3047	cAMP biosynthetic process
DM42_RS26880	COG0583	DNA-binding transcription factor activity
DM42_RS26885	COG2814	Major facilitator Superfamily
DM42_RS26890	COG1280	lysine exporter protein (LysE YggA)
DM42_RS26895	COG2084	Dehydrogenase
DM42_RS26915	COG1136	(ABC) transporter
DM42_RS26915	COG0577	efflux transmembrane transporter activity
DM42_RS26925	COG0577	efflux transmembrane transporter activity
DM42_RS26930	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
DM42_RS26945	COG0583	DNA-binding transcription factor activity
DM42_RS26950	COG2271	Major facilitator Superfamily
DM42_RS26970	COG2823	Periplasmic or secreted lipoprotein
DM42_RS26975	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
DM42_RS26990	COG3344	reverse transcriptase
DM42_RS27000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
DM42_RS27010	COG1522	sequence-specific DNA binding
DM42_RS27055	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DM42_RS27060	COG1950	PFAM Membrane protein of
DM42_RS27070	COG1191	sigma factor activity
DM42_RS27085	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DM42_RS27090	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DM42_RS27110	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
DM42_RS27115	COG0745	RESPONSE REGULATOR receiver
DM42_RS27130	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DM42_RS27135	COG0840	transmembrane signaling receptor activity
DM42_RS27145	COG2198	Histidine kinase
DM42_RS27145	COG0643	Histidine kinase
DM42_RS27150	COG0745	RESPONSE REGULATOR receiver
DM42_RS27155	COG1360	Flagellar Motor Protein
DM42_RS27175	COG0438	transferase activity, transferring glycosyl groups
DM42_RS27180	COG2916	Histone family protein nucleoid-structuring protein H-NS
DM42_RS27185	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DM42_RS27200	COG0519	Catalyzes the synthesis of GMP from XMP
DM42_RS27225	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DM42_RS27400	COG0582	viral genome integration into host DNA
DM42_RS27420	COG0210	DNA helicase
DM42_RS27430	COG0673	inositol 2-dehydrogenase activity
DM42_RS27440	COG0404	The glycine cleavage system catalyzes the degradation of glycine
DM42_RS27445	COG0509	glycine decarboxylation via glycine cleavage system
DM42_RS27450	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DM42_RS27450	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
DM42_RS27460	COG1760	l-serine dehydratase
DM42_RS27480	COG0028	Belongs to the TPP enzyme family
DM42_RS27500	COG1012	belongs to the aldehyde dehydrogenase family
DM42_RS27515	COG0583	DNA-binding transcription factor activity
DM42_RS27520	COG4302	ethanolamine ammonia-lyase activity
DM42_RS27525	COG4303	Ethanolamine ammonia lyase large subunit
DM42_RS27530	COG0531	amino acid
DM42_RS27535	COG0668	transmembrane transport
DM42_RS27555	COG0789	Transcriptional regulator
DM42_RS27565	COG0277	FAD linked oxidase domain protein
DM42_RS27570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM42_RS27575	COG3328	transposase activity
DM42_RS27585	COG0436	Aminotransferase
DM42_RS27595	COG1960	acyl-CoA dehydrogenase activity
DM42_RS27620	COG0683	leucine binding
DM42_RS27625	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DM42_RS27625	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
DM42_RS27625	COG0506	proline dehydrogenase activity
DM42_RS27630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DM42_RS27635	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
DM42_RS27645	COG0318	PFAM AMP-dependent synthetase and ligase
DM42_RS27660	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
DM42_RS27665	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
DM42_RS27670	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DM42_RS27685	COG0356	it plays a direct role in the translocation of protons across the membrane
DM42_RS27695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DM42_RS27700	COG1475	DNA binding
DM42_RS27705	COG1192	Involved in chromosome partitioning
DM42_RS27710	COG0357	Ribosomal RNA small subunit methyltransferase G
DM42_RS27715	COG0445	tRNA wobble uridine modification
DM42_RS27765	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
DM42_RS27770	COG0583	DNA-binding transcription factor activity
DM42_RS27780	COG1522	sequence-specific DNA binding
DM42_RS27785	COG3186	Phenylalanine-4-hydroxylase
DM42_RS27790	COG2154	pterin-4-alpha-carbinolamine dehydratase
DM42_RS27805	COG0642	Histidine kinase
DM42_RS27815	COG1902	pentaerythritol trinitrate reductase activity
DM42_RS27820	COG0519	Catalyzes the synthesis of GMP from XMP
DM42_RS27820	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DM42_RS27850	COG0523	cobalamin synthesis protein
DM42_RS27870	COG1459	type II secretion system
DM42_RS27885	COG2165	general secretion pathway protein
DM42_RS27930	COG1846	Transcriptional regulator
DM42_RS27935	COG2814	Major facilitator Superfamily
DM42_RS27945	COG0583	DNA-binding transcription factor activity
DM42_RS27950	COG1380	Effector of murein hydrolase LrgA
DM42_RS27955	COG1346	cytolysis
DM42_RS27970	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DM42_RS27980	COG1338	Plays a role in the flagellum-specific transport system
DM42_RS27985	COG1987	bacterial-type flagellum assembly
DM42_RS28005	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM42_RS28020	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM42_RS28050	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
DM42_RS28055	COG1262	PFAM Formylglycine-generating sulfatase enzyme
DM42_RS28065	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DM42_RS28100	COG0753	catalase activity
DM42_RS28105	COG3038	cytochrome b561
DM42_RS28145	COG4584	PFAM Integrase catalytic
DM42_RS28150	COG1484	DNA-dependent DNA replication
DM42_RS28160	COG1674	ftsk spoiiie
DM42_RS28185	COG0592	DNA-directed DNA polymerase activity
DM42_RS28190	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DM42_RS28205	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DM42_RS28235	COG4251	negative regulation of phosphorylation
DM42_RS28235	COG2203	Gaf domain
DM42_RS28235	COG5001	Diguanylate cyclase
DM42_RS28235	COG3706	GGDEF domain
DM42_RS28250	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DM42_RS28270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DM42_RS28270	COG2169	Transcriptional regulator
DM42_RS28290	COG1620	l-lactate permease
DM42_RS28295	COG0583	DNA-binding transcription factor activity
DM42_RS28300	COG3511	phospholipase C
DM42_RS28310	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DM42_RS28325	COG3842	ATPase activity
DM42_RS28330	COG1840	ABC-type Fe3 transport system, periplasmic component
DM42_RS28340	COG1012	belongs to the aldehyde dehydrogenase family
DM42_RS28345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DM42_RS28355	COG1126	abc transporter atp-binding protein
DM42_RS28385	COG4974	Belongs to the 'phage' integrase family
DM42_RS28580	COG4695	Portal protein
DM42_RS28630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DM42_RS28635	COG0583	DNA-binding transcription factor activity
DM42_RS28650	COG0758	DNA mediated transformation
DM42_RS28655	COG0242	peptide deformylase activity
DM42_RS28660	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DM42_RS28670	COG0501	Belongs to the peptidase M48B family
DM42_RS28685	COG5000	phosphorelay sensor kinase activity
DM42_RS28690	COG2204	response regulator
DM42_RS28700	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DM42_RS28705	COG0602	queuosine metabolic process
DM42_RS28710	COG0720	synthase
DM42_RS28725	COG0772	Belongs to the SEDS family
DM42_RS28730	COG0768	penicillin binding
DM42_RS28745	COG1077	Cell shape determining protein MreB Mrl
DM42_RS28755	COG0154	amidase activity
DM42_RS28760	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
DM42_RS28765	COG2326	polyphosphate kinase activity
DM42_RS28770	COG0708	Exodeoxyribonuclease III
DM42_RS28775	COG1064	alcohol dehydrogenase
DM42_RS28780	COG2207	Transcriptional regulator
DM42_RS28790	COG2814	Major facilitator Superfamily
DM42_RS28795	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DM42_RS28800	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
DM42_RS28830	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
DM42_RS28835	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DM42_RS28840	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
DM42_RS28850	COG0523	cobalamin synthesis protein
DM42_RS28860	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
DM42_RS28870	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DM42_RS28875	COG1560	Kdo2-lipid A biosynthetic process
DM42_RS28880	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DM42_RS28900	COG0667	Aldo Keto reductase
DM42_RS28965	COG1677	Flagellar hook-basal body complex protein FliE
DM42_RS28985	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DM42_RS29000	COG0531	amino acid
DM42_RS29005	COG2197	response regulator
DM42_RS29020	COG3568	Endonuclease Exonuclease Phosphatase
DM42_RS29035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DM42_RS29040	COG0579	oxidoreductase
DM42_RS29055	COG0747	negative chemotaxis
DM42_RS29060	COG0601	transmembrane transport
DM42_RS29065	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DM42_RS29070	COG0444	Belongs to the ABC transporter superfamily
DM42_RS29075	COG4608	Belongs to the ABC transporter superfamily
DM42_RS29090	COG1984	allophanate hydrolase subunit 2
DM42_RS29095	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DM42_RS29105	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
DM42_RS29110	COG0741	lytic transglycosylase activity
DM42_RS29125	COG0617	tRNA 3'-terminal CCA addition
DM42_RS29155	COG1815	bacterial-type flagellum-dependent cell motility
DM42_RS29160	COG1558	bacterial-type flagellum-dependent cell motility
DM42_RS29165	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DM42_RS29185	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
DM42_RS29190	COG1706	bacterial-type flagellum-dependent cell motility
DM42_RS29200	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
DM42_RS29210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DM42_RS29215	COG2233	PERMEase
DM42_RS29245	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
DM42_RS29275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DM42_RS29280	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DM42_RS29290	COG1177	transmembrane transport
DM42_RS29295	COG1176	ABC-type spermidine putrescine transport system, permease component I
DM42_RS29300	COG3842	ATPase activity
DM42_RS29315	COG0174	glutamine synthetase
DM42_RS29320	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DM42_RS29330	COG1012	belongs to the aldehyde dehydrogenase family
DM42_RS29345	COG0672	)-iron permease
DM42_RS29370	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DM42_RS29375	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DM42_RS29420	COG1609	Transcriptional regulator
DM42_RS29445	COG0583	DNA-binding transcription factor activity
DM42_RS29455	COG2948	multi-organism process
DM42_RS29470	COG3846	protein secretion by the type IV secretion system
DM42_RS29480	COG3451	type IV secretory pathway VirB4
DM42_RS29490	COG3838	Conjugal transfer protein Trbc
DM42_RS29495	COG4962	Type ii secretion system protein e
DM42_RS29525	COG0583	DNA-binding transcription factor activity
DM42_RS29540	COG2030	dehydratase
DM42_RS29545	COG1960	acyl-CoA dehydrogenase activity
DM42_RS29550	COG2814	Major facilitator Superfamily
DM42_RS29580	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DM42_RS29585	COG0318	PFAM AMP-dependent synthetase and ligase
DM42_RS29590	COG0183	Belongs to the thiolase family
DM42_RS29595	COG1024	Enoyl-CoA hydratase
DM42_RS29615	COG4959	Type IV secretory pathway protease TraF
DM42_RS29630	COG1192	Involved in chromosome partitioning
DM42_RS29655	COG1396	sequence-specific DNA binding
DM42_RS29660	COG5489	Protein of unknown function (DUF736)
DM42_RS29680	COG1475	DNA binding
DM42_RS29695	COG2003	Belongs to the UPF0758 family
DM42_RS29700	COG4804	nuclease activity
DM42_RS29715	COG0596	Alpha beta hydrolase
DM42_RS29720	COG1522	sequence-specific DNA binding
DM42_RS29745	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DM42_RS29760	COG2080	2 iron, 2 sulfur cluster binding
DM42_RS29765	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
DM42_RS29770	COG1529	Aldehyde oxidase and xanthine dehydrogenase
DM42_RS29775	COG0583	DNA-binding transcription factor activity
DM42_RS29780	COG0625	glutathione transferase activity
DM42_RS29790	COG0583	DNA-binding transcription factor activity
DM42_RS29805	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DM42_RS29820	COG0625	glutathione transferase activity
DM42_RS29825	COG0110	maltose O-acetyltransferase activity
DM42_RS29835	COG0025	NhaP-type Na H and K H
DM42_RS29840	COG2199	diguanylate cyclase activity
DM42_RS29840	COG2200	EAL domain
DM42_RS29870	COG1984	allophanate hydrolase subunit 2
DM42_RS29880	COG0439	Biotin carboxylase
DM42_RS29885	COG0511	ligase activity, forming carbon-carbon bonds
DM42_RS29890	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
DM42_RS29900	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
DM42_RS29905	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DM42_RS29910	COG0156	8-amino-7-oxononanoate synthase activity
DM42_RS29925	COG3012	SEC-C Motif Domain Protein
DM42_RS29930	COG0300	oxidoreductase activity
DM42_RS29935	COG0288	reversible hydration of carbon dioxide
DM42_RS29950	COG0488	(ABC) transporter
DM42_RS29955	COG0747	negative chemotaxis
DM42_RS29960	COG0300	oxidoreductase activity
DM42_RS29965	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
DM42_RS29975	COG0018	arginyl-trna synthetase
DM42_RS30020	COG1024	Enoyl-CoA hydratase
DM42_RS30040	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
DM42_RS30050	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DM42_RS30055	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DM42_RS30055	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DM42_RS30065	COG0737	Belongs to the 5'-nucleotidase family
DM42_RS30070	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DM42_RS30075	COG1127	ABC transporter
DM42_RS30105	COG1686	Belongs to the peptidase S11 family
DM42_RS30115	COG2921	Belongs to the UPF0250 family
DM42_RS30120	COG0583	DNA-binding transcription factor activity
DM42_RS30140	COG4521	taurine ABC transporter
DM42_RS30150	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM42_RS30155	COG0405	Gamma-glutamyltransferase
DM42_RS30160	COG0583	DNA-binding transcription factor activity
DM42_RS30170	COG1960	acyl-CoA dehydrogenase activity
DM42_RS30175	COG1960	acyl-CoA dehydrogenase activity
DM42_RS30180	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DM42_RS30190	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DM42_RS30200	COG4191	Histidine kinase
DM42_RS30220	COG0606	chelatase, subunit chli
DM42_RS30225	COG2960	long-chain fatty acid transporting porin activity
DM42_RS30235	COG0004	ammonium transporteR
DM42_RS30245	COG0189	ligase activity
DM42_RS30255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
DM42_RS30260	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DM42_RS30265	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
DM42_RS30270	COG0793	Belongs to the peptidase S41A family
DM42_RS30275	COG0588	phosphoglycerate mutase activity
DM42_RS30280	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
DM42_RS30290	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
DM42_RS30295	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
DM42_RS30300	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DM42_RS30310	COG1040	competence protein
DM42_RS30315	COG2226	methyltransferase
DM42_RS30330	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
DM42_RS30340	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
DM42_RS30370	COG1612	heme a metabolic process
DM42_RS30380	COG1999	signal sequence binding
DM42_RS30390	COG0840	transmembrane signaling receptor activity
DM42_RS30415	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
DM42_RS30430	COG0587	DNA-directed DNA polymerase activity
DM42_RS30435	COG2188	Transcriptional regulator
DM42_RS30440	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
DM42_RS30445	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DM42_RS30450	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
DM42_RS30450	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
DM42_RS30455	COG2190	(PTS) system
DM42_RS30455	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
DM42_RS30455	COG1263	PTS System
DM42_RS30470	COG1294	oxidase, subunit
DM42_RS30485	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DM42_RS30500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DM42_RS30505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DM42_RS30510	COG0625	glutathione transferase activity
DM42_RS30520	COG0742	ribosomal rna small subunit methyltransferase
DM42_RS30530	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DM42_RS30550	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DM42_RS30560	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
DM42_RS30565	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
DM42_RS30575	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
DM42_RS30580	COG1194	a g-specific adenine glycosylase
DM42_RS30590	COG1660	Displays ATPase and GTPase activities
DM42_RS30605	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
DM42_RS30610	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DM42_RS30615	COG1137	ATPase activity
DM42_RS30630	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
DM42_RS30650	COG1280	lysine exporter protein (LysE YggA)
DM42_RS30675	COG2814	Major facilitator Superfamily
DM42_RS30680	COG0629	single-stranded DNA binding
DM42_RS30685	COG3663	DNA glycosylase
DM42_RS30705	COG0183	Belongs to the thiolase family
DM42_RS30710	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS30735	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DM42_RS30760	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
DM42_RS30775	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS30790	COG0501	Belongs to the peptidase M48B family
DM42_RS30795	COG1620	l-lactate permease
DM42_RS30800	COG1139	Iron-sulfur cluster binding protein
DM42_RS30810	COG0247	lactate metabolic process
DM42_RS30815	COG2186	Transcriptional regulator
DM42_RS30820	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
DM42_RS30825	COG0235	Class ii aldolase
DM42_RS30850	COG0477	Major facilitator Superfamily
DM42_RS30870	COG1737	Transcriptional regulator
DM42_RS30870	COG0837	glucose binding
DM42_RS30875	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
DM42_RS30880	COG0251	oxidation-reduction process
DM42_RS30885	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DM42_RS30885	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DM42_RS30890	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DM42_RS30930	COG0500	methyltransferase
DM42_RS30945	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
DM42_RS30950	COG0494	nUDIX hydrolase
DM42_RS30965	COG1960	acyl-CoA dehydrogenase activity
DM42_RS30970	COG1024	Enoyl-CoA hydratase
DM42_RS30970	COG1250	3-hydroxyacyl-CoA dehydrogenase
DM42_RS30975	COG0183	Belongs to the thiolase family
DM42_RS30980	COG1024	Enoyl-CoA hydratase
DM42_RS30985	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DM42_RS31000	COG5265	(ABC) transporter
DM42_RS31025	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DM42_RS31050	COG0204	Acyl-transferase
DM42_RS31055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DM42_RS31060	COG0751	glycine-tRNA ligase activity
DM42_RS31065	COG0752	glycyl-tRNA synthetase alpha subunit
DM42_RS31075	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DM42_RS31085	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
DM42_RS31095	COG1702	phosphate starvation-inducible protein PhoH
DM42_RS31100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DM42_RS31105	COG0583	DNA-binding transcription factor activity
DM42_RS31110	COG2814	Major facilitator Superfamily
DM42_RS31115	COG1396	sequence-specific DNA binding
DM42_RS31125	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DM42_RS31130	COG0673	inositol 2-dehydrogenase activity
DM42_RS31165	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
DM42_RS31210	COG0513	Belongs to the DEAD box helicase family
DM42_RS31220	COG2863	cytochrome
DM42_RS31230	COG4948	Mandelate Racemase Muconate Lactonizing
DM42_RS31235	COG2186	Transcriptional regulator
DM42_RS31240	COG3813	Protein conserved in bacteria
DM42_RS31255	COG0583	DNA-binding transcription factor activity
DM42_RS31275	COG4977	sequence-specific DNA binding
DM42_RS31280	COG0583	DNA-binding transcription factor activity
DM42_RS31305	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DM42_RS31310	COG2137	regulation of response to DNA damage stimulus
DM42_RS31320	COG0045	succinate-CoA ligase (ADP-forming) activity
DM42_RS31325	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DM42_RS31330	COG0861	Integral membrane protein TerC family
DM42_RS31335	COG4969	Belongs to the N-Me-Phe pilin family
DM42_RS31350	COG0315	cyclic pyranopterin monophosphate synthase activity
DM42_RS31355	COG4783	chaperone-mediated protein folding
DM42_RS31360	COG2801	Transposase and inactivated derivatives
DM42_RS31375	COG0429	hydrolase of the alpha beta-hydrolase fold
DM42_RS31410	COG0126	phosphoglycerate kinase activity
DM42_RS31415	COG0469	pyruvate kinase activity
DM42_RS31425	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DM42_RS31430	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DM42_RS31435	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
DM42_RS31440	COG0009	L-threonylcarbamoyladenylate synthase
DM42_RS31455	COG2027	D-alanyl-D-alanine carboxypeptidase
DM42_RS31470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DM42_RS31490	COG4977	sequence-specific DNA binding
DM42_RS31510	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM42_RS31520	COG2233	PERMEase
DM42_RS31525	COG1070	Carbohydrate kinase
DM42_RS31535	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
DM42_RS31540	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DM42_RS31545	COG1121	(ABC) transporter
DM42_RS31555	COG0735	belongs to the Fur family
DM42_RS31565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DM42_RS31570	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
DM42_RS31580	COG4209	transmembrane transport
DM42_RS31590	COG0546	phosphoglycolate phosphatase activity
DM42_RS31595	COG3842	ATPase activity
DM42_RS31600	COG0583	DNA-binding transcription factor activity
DM42_RS31615	COG2390	Transcriptional regulator
DM42_RS31620	COG1070	Carbohydrate kinase
DM42_RS31625	COG0246	Mannitol dehydrogenase
DM42_RS31640	COG1012	belongs to the aldehyde dehydrogenase family
DM42_RS31645	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DM42_RS31665	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
DM42_RS31670	COG1522	sequence-specific DNA binding
DM42_RS31675	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
DM42_RS31695	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DM42_RS31705	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DM42_RS31710	COG0259	pyridoxamine-phosphate oxidase activity
DM42_RS31715	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
DM42_RS31725	COG1741	Belongs to the pirin family
DM42_RS31740	COG0860	N-Acetylmuramoyl-L-alanine amidase
DM42_RS31745	COG0802	atpase or kinase
DM42_RS31750	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DM42_RS31760	COG4974	Belongs to the 'phage' integrase family
DM42_RS31765	COG0318	PFAM AMP-dependent synthetase and ligase
DM42_RS31770	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
DM42_RS31775	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
DM42_RS31780	COG1666	GTP binding
DM42_RS31805	COG0728	peptidoglycan biosynthetic process
DM42_RS31820	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DM42_RS31830	COG1663	tetraacyldisaccharide 4'-kinase activity
DM42_RS31835	COG1570	exodeoxyribonuclease VII activity
DM42_RS31840	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DM42_RS31860	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DM42_RS31875	COG2814	Major facilitator Superfamily
DM42_RS31890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DM42_RS31895	COG2188	Transcriptional regulator
DM42_RS31900	COG0656	L-ascorbic acid biosynthetic process
DM42_RS31910	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
DM42_RS31955	COG1278	Cold shock
DM42_RS31965	COG0542	response to heat
DM42_RS31970	COG1113	amino acid transport
DM42_RS31980	COG0756	dUTP diphosphatase activity
DM42_RS31985	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
DM42_RS31990	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DM42_RS31995	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DM42_RS32000	COG0196	riboflavin kinase activity
DM42_RS32005	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DM42_RS32010	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DM42_RS32010	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
DM42_RS32015	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
DM42_RS32015	COG3264	Mechanosensitive ion channel
DM42_RS32035	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DM42_RS32055	COG1047	Peptidyl-prolyl cis-trans
DM42_RS32060	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
DM42_RS32095	COG0456	acetyltransferase
DM42_RS32100	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DM42_RS32120	COG1187	pseudouridine synthase activity
DM42_RS32135	COG4221	oxidoreductase activity
DM42_RS32140	COG0583	DNA-binding transcription factor activity
DM42_RS32155	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS32160	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS32180	COG0583	DNA-binding transcription factor activity
DM42_RS32195	COG0175	sulfate reduction
DM42_RS32205	COG2895	sulfate adenylyltransferase (ATP) activity
DM42_RS32210	COG1648	precorrin-2 dehydrogenase activity
DM42_RS32210	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
DM42_RS32230	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DM42_RS32245	COG4654	Cytochrome c, class I
DM42_RS32255	COG0583	DNA-binding transcription factor activity
DM42_RS32260	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
DM42_RS32285	COG4139	cobalamin transport
DM42_RS32290	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
DM42_RS32295	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
DM42_RS32300	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
DM42_RS32310	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DM42_RS32320	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
DM42_RS32330	COG1492	cobalamin metabolic process
DM42_RS32335	COG2259	Doxx family
DM42_RS32345	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
DM42_RS32350	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
DM42_RS32355	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
DM42_RS32375	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DM42_RS32375	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DM42_RS32380	COG3047	cAMP biosynthetic process
DM42_RS32380	COG2885	chlorophyll binding
DM42_RS32385	COG0489	protein tyrosine kinase activity
DM42_RS32410	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
DM42_RS32415	COG0165	Argininosuccinate lyase
DM42_RS32445	COG2226	methyltransferase
DM42_RS32450	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
DM42_RS32455	COG0181	hydroxymethylbilane synthase activity
DM42_RS32480	COG0596	Alpha beta hydrolase
DM42_RS32490	COG2271	Major facilitator Superfamily
DM42_RS32505	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DM42_RS32510	COG2827	Endonuclease containing a URI domain
DM42_RS32520	COG1472	Belongs to the glycosyl hydrolase 3 family
DM42_RS32545	COG0583	DNA-binding transcription factor activity
DM42_RS32575	COG1741	Belongs to the pirin family
DM42_RS32600	COG1176	ABC-type spermidine putrescine transport system, permease component I
DM42_RS32605	COG1116	anion transmembrane transporter activity
DM42_RS32630	COG2814	Major facilitator Superfamily
DM42_RS32655	COG1309	transcriptional regulator
DM42_RS32660	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS32685	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DM42_RS32710	COG0488	(ABC) transporter
DM42_RS32730	COG0583	DNA-binding transcription factor activity
DM42_RS32740	COG2059	Chromate
DM42_RS32745	COG5001	Diguanylate cyclase
DM42_RS32750	COG0384	phenazine biosynthesis protein PhzF
DM42_RS32760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
DM42_RS32765	COG0697	spore germination
DM42_RS32805	COG4106	trans-aconitate 2-methyltransferase activity
DM42_RS32825	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DM42_RS32830	COG3135	benzoate transporter
DM42_RS32840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DM42_RS32865	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DM42_RS32870	COG2878	Part of a membrane complex involved in electron transport
DM42_RS32875	COG1309	transcriptional regulator
DM42_RS32885	COG3387	PFAM Glycoside hydrolase 15-related
DM42_RS32890	COG2706	6-phosphogluconolactonase activity
DM42_RS32895	COG1674	ftsk spoiiie
DM42_RS32915	COG3895	Periplasmic Protein
DM42_RS32920	COG0513	Belongs to the DEAD box helicase family
DM42_RS32925	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DM42_RS32930	COG1054	Belongs to the UPF0176 family
DM42_RS32965	COG0438	transferase activity, transferring glycosyl groups
DM42_RS32970	COG0859	PFAM glycosyl transferase family 9
DM42_RS32975	COG0463	Glycosyl transferase, family 2
DM42_RS33005	COG3171	Protein conserved in bacteria
DM42_RS33010	COG1530	ribonuclease E activity
DM42_RS33020	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
DM42_RS33025	COG0799	negative regulation of ribosome biogenesis
DM42_RS33030	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DM42_RS33035	COG0408	coproporphyrinogen oxidase activity
DM42_RS33040	COG0151	Belongs to the GarS family
DM42_RS33050	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DM42_RS33055	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS33080	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
DM42_RS33085	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
DM42_RS33090	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
DM42_RS33095	COG2205	protein histidine kinase activity
DM42_RS33100	COG0745	RESPONSE REGULATOR receiver
DM42_RS33130	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DM42_RS33140	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DM42_RS33145	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS33165	COG0438	transferase activity, transferring glycosyl groups
DM42_RS33195	COG0028	Belongs to the TPP enzyme family
DM42_RS33205	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DM42_RS33210	COG0688	phosphatidylethanolamine metabolic process
DM42_RS33215	COG1183	phosphatidylcholine synthase activity
DM42_RS33220	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DM42_RS33225	COG0659	secondary active sulfate transmembrane transporter activity
DM42_RS33230	COG0288	reversible hydration of carbon dioxide
DM42_RS33240	COG0683	leucine binding
DM42_RS33250	COG1185	polyribonucleotide nucleotidyltransferase activity
DM42_RS33255	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
DM42_RS33255	COG0604	alcohol dehydrogenase
DM42_RS33255	COG4221	oxidoreductase activity
DM42_RS33255	COG3321	synthase
DM42_RS33260	COG0149	triose-phosphate isomerase activity
DM42_RS33295	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
DM42_RS33305	COG1034	ATP synthesis coupled electron transport
DM42_RS33305	COG1034	ATP synthesis coupled electron transport
DM42_RS33310	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
DM42_RS33315	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DM42_RS33340	COG1007	ATP synthesis coupled electron transport
DM42_RS33360	COG1960	acyl-CoA dehydrogenase activity
DM42_RS33365	COG1960	acyl-CoA dehydrogenase activity
DM42_RS33380	COG0625	glutathione transferase activity
DM42_RS33385	COG1024	Enoyl-CoA hydratase
DM42_RS33395	COG0436	Aminotransferase
DM42_RS33405	COG3022	response to hydroperoxide
DM42_RS33410	COG2866	Carboxypeptidase
DM42_RS33470	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
DM42_RS33475	COG0667	Aldo Keto reductase
DM42_RS33490	COG0556	nucleotide-excision repair
DM42_RS33500	COG4633	Protein conserved in bacteria
DM42_RS33505	COG0672	)-iron permease
DM42_RS33525	COG1741	Belongs to the pirin family
DM42_RS33555	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DM42_RS33590	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DM42_RS33645	COG2304	oxidoreductase activity
DM42_RS33655	COG2310	stress, protein
DM42_RS33695	COG0529	Catalyzes the synthesis of activated sulfate
DM42_RS33695	COG2895	sulfate adenylyltransferase (ATP) activity
DM42_RS33715	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS33735	COG0415	Belongs to the DNA photolyase family
DM42_RS33750	COG0583	DNA-binding transcription factor activity
DM42_RS33770	COG2986	histidine ammonia-lyase
DM42_RS33780	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
DM42_RS33790	COG1228	amidohydrolase
DM42_RS33805	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
DM42_RS33810	COG0174	glutamine synthetase
DM42_RS33825	COG0583	DNA-binding transcription factor activity
DM42_RS33830	COG1960	acyl-CoA dehydrogenase activity
DM42_RS33835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DM42_RS33840	COG0477	Major facilitator Superfamily
DM42_RS33850	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
DM42_RS33850	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DM42_RS33855	COG1643	Atp-dependent helicase
DM42_RS33875	COG1546	Belongs to the CinA family
DM42_RS33875	COG1058	Belongs to the CinA family
DM42_RS33885	COG0174	glutamine synthetase
DM42_RS33900	COG1505	serine-type exopeptidase activity
DM42_RS33920	COG1794	racemase activity, acting on amino acids and derivatives
DM42_RS33925	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
DM42_RS33930	COG0339	signal peptide processing
DM42_RS33935	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
DM42_RS33940	COG4566	intracellular signal transduction
DM42_RS33950	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
DM42_RS33955	COG0508	dehydrogenase complex catalyzes the overall conversion of
DM42_RS33960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
DM42_RS33975	COG1414	Transcriptional regulator
DM42_RS33995	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DM42_RS34005	COG1104	cysteine desulfurase activity
DM42_RS34010	COG0822	iron-sulfur transferase activity
DM42_RS34015	COG0316	Belongs to the HesB IscA family
DM42_RS34020	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DM42_RS34025	COG0443	Heat shock 70 kDa protein
DM42_RS34045	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
DM42_RS34055	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DM42_RS34075	COG0084	hydrolase, TatD family'
DM42_RS34080	COG0658	competence protein
DM42_RS34080	COG2333	competence protein COMEC
DM42_RS34095	COG2877	3-deoxy-8-phosphooctulonate synthase activity
DM42_RS34105	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
DM42_RS34115	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
DM42_RS34125	COG2833	Protein of unknown function (DUF455)
DM42_RS34130	COG0596	Alpha beta hydrolase
DM42_RS34135	COG0613	PHP domain protein
DM42_RS34140	COG0009	L-threonylcarbamoyladenylate synthase
DM42_RS34145	COG1994	Peptidase M50
DM42_RS34150	COG0180	Tryptophanyl-tRNA synthetase
DM42_RS34160	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DM42_RS34165	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
DM42_RS34170	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
DM42_RS34175	COG2850	peptidyl-arginine hydroxylation
DM42_RS34190	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
DM42_RS34200	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
DM42_RS34205	COG0483	inositol monophosphate 1-phosphatase activity
DM42_RS34215	COG1045	serine acetyltransferase
DM42_RS34220	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DM42_RS34230	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DM42_RS34240	COG0215	cysteine-tRNA ligase activity
DM42_RS34255	COG0037	tRNA processing
DM42_RS34260	COG0527	aspartate kinase activity
DM42_RS34310	COG0745	RESPONSE REGULATOR receiver
DM42_RS34315	COG0642	Histidine kinase
DM42_RS34355	COG4174	ABC transporter (Permease)
DM42_RS34360	COG4239	(ABC) transporter, permease
DM42_RS34365	COG4172	Belongs to the ABC transporter superfamily
DM42_RS34370	COG0791	NLP P60 protein
DM42_RS34375	COG1752	Esterase of the alpha-beta hydrolase superfamily
DM42_RS34380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DM42_RS34435	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
DM42_RS34445	COG0583	DNA-binding transcription factor activity
DM42_RS34455	COG2224	Isocitrate lyase
DM42_RS34460	COG0513	Belongs to the DEAD box helicase family
DM42_RS34470	COG1214	PFAM Peptidase M22, glycoprotease
DM42_RS34480	COG1573	uracil-dna glycosylase
DM42_RS34490	COG0351	phosphomethylpyrimidine kinase
DM42_RS34495	COG0477	Major facilitator Superfamily
DM42_RS34515	COG0488	(ABC) transporter
DM42_RS34520	COG0386	Belongs to the glutathione peroxidase family
DM42_RS34530	COG2890	protein-(glutamine-N5) methyltransferase activity
DM42_RS34535	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DM42_RS34540	COG1393	Belongs to the ArsC family
DM42_RS34570	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DM42_RS34575	COG0242	peptide deformylase activity
DM42_RS34580	COG1187	pseudouridine synthase activity
DM42_RS34590	COG0024	Methionine aminopeptidase
DM42_RS34595	COG0052	Belongs to the universal ribosomal protein uS2 family
DM42_RS34600	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
DM42_RS34610	COG0233	cytoplasmic translational termination
DM42_RS34615	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
DM42_RS34630	COG0750	zinc metalloprotease
DM42_RS34645	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DM42_RS34655	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DM42_RS34660	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DM42_RS34665	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
DM42_RS34670	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
DM42_RS34675	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
DM42_RS34690	COG0330	HflC and HflK could
DM42_RS34705	COG2914	Belongs to the UPF0125 (RnfH) family
DM42_RS34710	COG0697	spore germination
DM42_RS34745	COG0519	Catalyzes the synthesis of GMP from XMP
DM42_RS34745	COG0518	GMP synthase (glutamine-hydrolyzing) activity
DM42_RS34750	COG2176	DNA-directed DNA polymerase activity
DM42_RS34760	COG0456	acetyltransferase
DM42_RS34790	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
DM42_RS34805	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
DM42_RS34810	COG2188	Transcriptional regulator
DM42_RS34825	COG0590	tRNA wobble adenosine to inosine editing
DM42_RS34830	COG1619	proteins homologs of microcin C7 resistance protein MccF
DM42_RS34840	COG1953	Uracil, thiamine, allantoin
DM42_RS34855	COG3195	allantoin biosynthetic process
DM42_RS34855	COG3648	Uricase
DM42_RS34860	COG4266	Belongs to the allantoicase family
DM42_RS34875	COG0251	oxidation-reduction process
DM42_RS34885	COG0583	DNA-binding transcription factor activity
DM42_RS34900	COG2351	hydroxyisourate hydrolase activity
DM42_RS34915	COG3360	Dodecin
DM42_RS34930	COG1970	mechanosensitive ion channel activity
DM42_RS34960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
DM42_RS34965	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DM42_RS34970	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
DM42_RS34980	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
DM42_RS35060	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
DM42_RS35070	COG1929	Belongs to the glycerate kinase type-1 family
DM42_RS35075	COG0544	peptidyl-prolyl cis-trans isomerase activity
DM42_RS35090	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DM42_RS35115	COG4181	ATPase activity
DM42_RS35120	COG0166	Belongs to the GPI family
DM42_RS35130	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
DM42_RS35135	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DM42_RS35135	COG0047	phosphoribosylformylglycinamidine synthase activity
DM42_RS35145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DM42_RS35155	COG2917	probably involved in intracellular septation
DM42_RS35160	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DM42_RS35165	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
DM42_RS35170	COG0318	PFAM AMP-dependent synthetase and ligase
DM42_RS35180	COG1335	isochorismatase
DM42_RS35185	COG0183	Belongs to the thiolase family
DM42_RS35240	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
DM42_RS35245	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DM42_RS35255	COG0084	hydrolase, TatD family'
DM42_RS35280	COG0438	transferase activity, transferring glycosyl groups
DM42_RS35300	COG0252	asparaginase activity
DM42_RS35305	COG1652	LysM domain
DM42_RS35310	COG2084	Dehydrogenase
DM42_RS35315	COG3622	Belongs to the hyi family
DM42_RS35320	COG3960	tartronate-semialdehyde synthase activity
DM42_RS35325	COG0583	DNA-binding transcription factor activity
DM42_RS35345	COG2965	DNA replication, synthesis of RNA primer
DM42_RS35360	COG0305	Participates in initiation and elongation during chromosome replication
DM42_RS35370	COG0306	phosphate transporter
DM42_RS35375	COG0791	NLP P60 protein
DM42_RS35380	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
DM42_RS35385	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DM42_RS35390	COG0726	polysaccharide deacetylase
DM42_RS35395	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DM42_RS35395	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DM42_RS35405	COG0463	Glycosyl transferase, family 2
DM42_RS35410	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DM42_RS35415	COG2076	Multidrug Resistance protein
DM42_RS35420	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
DM42_RS35430	COG0436	Aminotransferase
DM42_RS35450	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
DM42_RS35455	COG0314	molybdopterin synthase activity
DM42_RS35460	COG2346	COG2346, Truncated hemoglobins
DM42_RS35465	COG1959	2 iron, 2 sulfur cluster binding
DM42_RS35470	COG0542	response to heat
DM42_RS35495	COG3284	Transcriptional regulator
DM42_RS35500	COG3199	ATP-NAD kinase
DM42_RS35505	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS35510	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
DM42_RS35515	COG0022	dehydrogenase e1 component
DM42_RS35525	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
DM42_RS35530	COG0534	Mate efflux family protein
DM42_RS35540	COG0254	rRNA binding
DM42_RS35545	COG3228	Belongs to the MtfA family
DM42_RS35550	COG0477	Major facilitator Superfamily
DM42_RS35560	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DM42_RS35570	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DM42_RS35585	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DM42_RS35625	COG0670	Belongs to the BI1 family
DM42_RS35635	COG0820	rRNA (adenine-C2-)-methyltransferase activity
DM42_RS35645	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DM42_RS35660	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DM42_RS35665	COG1160	GTP binding
DM42_RS35675	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
DM42_RS35680	COG0330	HflC and HflK could
DM42_RS35685	COG0330	HflC and HflK could
DM42_RS35705	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
DM42_RS35725	COG2183	response to ionizing radiation
DM42_RS35740	COG1199	ATP-dependent helicase activity
DM42_RS35750	COG0564	pseudouridine synthase activity
DM42_RS35760	COG3243	poly(R)-hydroxyalkanoic acid synthase
DM42_RS35765	COG0183	Belongs to the thiolase family
DM42_RS35770	COG1028	Short-chain dehydrogenase reductase Sdr
DM42_RS35785	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
DM42_RS35880	COG0419	ATPase involved in DNA repair
DM42_RS35885	COG1674	ftsk spoiiie
DM42_RS35920	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DM42_RS36010	COG5410	chromosome segregation
DM42_RS36200	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DM42_RS36215	COG0626	cystathionine gamma-synthase activity
DM42_RS36220	COG0560	Phosphoserine phosphatase
DM42_RS36225	COG0583	DNA-binding transcription factor activity
DM42_RS36245	COG0390	transport system, permease component
DM42_RS36250	COG1122	ATPase activity
DM42_RS36255	COG2982	Protein involved in outer membrane biogenesis
DM42_RS36265	COG0488	(ABC) transporter
DM42_RS36280	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DM42_RS36290	COG1819	glycosyl
DM42_RS36305	COG0726	polysaccharide deacetylase
DM42_RS36330	COG2070	2-Nitropropane dioxygenase
DM42_RS36335	COG3047	cAMP biosynthetic process
DM42_RS36340	COG3188	usher protein
DM42_RS36345	COG3121	Chaperone
DM42_RS36350	COG3539	Fimbrial protein
DM42_RS36360	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
DM42_RS36365	COG3842	ATPase activity
DM42_RS36370	COG1176	ABC-type spermidine putrescine transport system, permease component I
DM42_RS36375	COG1177	transmembrane transport
DM42_RS36380	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DM42_RS36380	COG0730	response to heat
DM42_RS36405	COG3655	Transcriptional regulator
DM42_RS36425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM42_RS36430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DM42_RS36440	COG0038	chloride channel
DM42_RS36445	COG2855	membrane
DM42_RS36460	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
DM42_RS36475	COG1609	Transcriptional regulator
DM42_RS36520	COG0598	Magnesium transport protein CorA
DM42_RS36560	COG1396	sequence-specific DNA binding
DM42_RS36565	COG4771	TonB-dependent receptor
DM42_RS36570	COG4166	transmembrane transport
DM42_RS36575	COG4174	ABC transporter (Permease)
DM42_RS36580	COG4239	(ABC) transporter, permease
DM42_RS36585	COG4172	Belongs to the ABC transporter superfamily
DM42_RS36590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
DM42_RS36595	COG4771	TonB-dependent receptor
DM42_RS36610	COG4638	Rieske (2fe-2S)
DM42_RS36645	COG0477	Major facilitator Superfamily
DM42_RS36650	COG1764	response to oxidative stress
DM42_RS36675	COG1846	Transcriptional regulator
DM42_RS36685	COG2070	2-Nitropropane dioxygenase
DM42_RS36710	COG2271	Major facilitator Superfamily
DM42_RS36715	COG0583	DNA-binding transcription factor activity
DM42_RS36730	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
DM42_RS36735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
DM42_RS36755	COG1074	ATP-dependent DNA helicase activity
DM42_RS36805	COG1216	Glycosyl transferase, family 2
DM42_RS36805	COG0438	transferase activity, transferring glycosyl groups
DM42_RS36835	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA