locus-tag	class	description
I6G56_RS00015	COG0765	amino acid transport
I6G56_RS00025	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G56_RS00030	COG2188	Transcriptional regulator
I6G56_RS00035	COG2986	histidine ammonia-lyase
I6G56_RS00040	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6G56_RS00045	COG0277	FAD linked oxidase domain protein
I6G56_RS00065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6G56_RS00070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G56_RS00095	COG0765	amino acid transport
I6G56_RS00100	COG0765	amino acid transport
I6G56_RS00105	COG1126	abc transporter atp-binding protein
I6G56_RS00110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G56_RS00115	COG1802	Transcriptional regulator
I6G56_RS00120	COG3328	transposase activity
I6G56_RS00130	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS00135	COG2814	Major facilitator Superfamily
I6G56_RS00140	COG1022	Amp-dependent synthetase and ligase
I6G56_RS00140	COG3320	Male sterility
I6G56_RS00145	COG1012	belongs to the aldehyde dehydrogenase family
I6G56_RS00150	COG1024	Enoyl-CoA hydratase
I6G56_RS00220	COG4974	Belongs to the 'phage' integrase family
I6G56_RS00245	COG1487	ribonuclease activity
I6G56_RS00250	COG4456	Virulence-associated protein
I6G56_RS00260	COG1475	DNA binding
I6G56_RS00265	COG1192	Involved in chromosome partitioning
I6G56_RS00280	COG3436	PFAM IS66 Orf2 family protein
I6G56_RS00290	COG4372	Transposase
I6G56_RS00315	COG1653	transport
I6G56_RS00320	COG1175	transmembrane transport
I6G56_RS00330	COG3842	ATPase activity
I6G56_RS00350	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G56_RS00355	COG0235	Class ii aldolase
I6G56_RS00360	COG1070	Carbohydrate kinase
I6G56_RS00390	COG1461	Dihydroxyacetone kinase
I6G56_RS00405	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6G56_RS00410	COG0191	fructose-bisphosphate aldolase activity
I6G56_RS00415	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6G56_RS00425	COG2376	Dihydroxyacetone kinase
I6G56_RS00430	COG1063	alcohol dehydrogenase
I6G56_RS00435	COG0698	ribose 5-phosphate isomerase
I6G56_RS00440	COG2390	Transcriptional regulator
I6G56_RS00450	COG1129	ABC transporter
I6G56_RS00455	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G56_RS00470	COG1070	Carbohydrate kinase
I6G56_RS00475	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G56_RS00485	COG4453	Protein conserved in bacteria
I6G56_RS00540	COG4964	Belongs to the GSP D family
I6G56_RS00775	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G56_RS00810	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6G56_RS00815	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G56_RS00835	COG4232	protein-disulfide reductase activity
I6G56_RS01035	COG2175	clavaminate synthase activity
I6G56_RS01055	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I6G56_RS01080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G56_RS01085	COG0339	signal peptide processing
I6G56_RS01100	COG0475	glutathione-regulated potassium exporter activity
I6G56_RS01155	COG4372	Transposase
I6G56_RS01160	COG3436	PFAM IS66 Orf2 family protein
I6G56_RS01175	COG2079	MmgE PrpD family protein
I6G56_RS01205	COG0165	Argininosuccinate lyase
I6G56_RS01210	COG0583	DNA-binding transcription factor activity
I6G56_RS01265	COG1960	acyl-CoA dehydrogenase activity
I6G56_RS01290	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6G56_RS01290	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G56_RS01340	COG0356	it plays a direct role in the translocation of protons across the membrane
I6G56_RS01350	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6G56_RS01355	COG1475	DNA binding
I6G56_RS01360	COG1192	Involved in chromosome partitioning
I6G56_RS01375	COG3344	reverse transcriptase
I6G56_RS01410	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6G56_RS01430	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
I6G56_RS01440	COG0583	DNA-binding transcription factor activity
I6G56_RS01450	COG1522	sequence-specific DNA binding
I6G56_RS01455	COG3186	Phenylalanine-4-hydroxylase
I6G56_RS01475	COG0642	Histidine kinase
I6G56_RS01485	COG1902	pentaerythritol trinitrate reductase activity
I6G56_RS01490	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G56_RS01490	COG0519	Catalyzes the synthesis of GMP from XMP
I6G56_RS01525	COG0523	cobalamin synthesis protein
I6G56_RS01560	COG2165	general secretion pathway protein
I6G56_RS01605	COG1846	Transcriptional regulator
I6G56_RS01610	COG2814	Major facilitator Superfamily
I6G56_RS01615	COG0583	DNA-binding transcription factor activity
I6G56_RS01625	COG1346	cytolysis
I6G56_RS01640	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G56_RS01650	COG1338	Plays a role in the flagellum-specific transport system
I6G56_RS01655	COG1987	bacterial-type flagellum assembly
I6G56_RS01665	COG0789	Transcriptional regulator
I6G56_RS01670	COG2226	methyltransferase
I6G56_RS01680	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G56_RS01690	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G56_RS01705	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS01720	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS01780	COG1695	Transcriptional regulator
I6G56_RS01805	COG1960	acyl-CoA dehydrogenase activity
I6G56_RS01810	COG0183	Belongs to the thiolase family
I6G56_RS01820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G56_RS01860	COG0753	catalase activity
I6G56_RS01875	COG3620	sequence-specific DNA binding
I6G56_RS01910	COG0592	DNA-directed DNA polymerase activity
I6G56_RS01970	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G56_RS01995	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G56_RS01995	COG2169	Transcriptional regulator
I6G56_RS02010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G56_RS02020	COG0583	DNA-binding transcription factor activity
I6G56_RS02035	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G56_RS02050	COG1177	transmembrane transport
I6G56_RS02055	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G56_RS02080	COG1960	acyl-CoA dehydrogenase activity
I6G56_RS02085	COG0318	PFAM AMP-dependent synthetase and ligase
I6G56_RS02095	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS02115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G56_RS02120	COG0583	DNA-binding transcription factor activity
I6G56_RS02135	COG0758	DNA mediated transformation
I6G56_RS02140	COG0242	peptide deformylase activity
I6G56_RS02170	COG5000	phosphorelay sensor kinase activity
I6G56_RS02175	COG2204	response regulator
I6G56_RS02190	COG0602	queuosine metabolic process
I6G56_RS02195	COG0720	synthase
I6G56_RS02210	COG0772	Belongs to the SEDS family
I6G56_RS02215	COG0768	penicillin binding
I6G56_RS02230	COG1077	Cell shape determining protein MreB Mrl
I6G56_RS02250	COG2326	polyphosphate kinase activity
I6G56_RS02255	COG0708	Exodeoxyribonuclease III
I6G56_RS02260	COG1064	alcohol dehydrogenase
I6G56_RS02265	COG2207	Transcriptional regulator
I6G56_RS02275	COG2814	Major facilitator Superfamily
I6G56_RS02295	COG1309	transcriptional regulator
I6G56_RS02320	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
I6G56_RS02330	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I6G56_RS02340	COG0523	cobalamin synthesis protein
I6G56_RS02350	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
I6G56_RS02365	COG1560	Kdo2-lipid A biosynthetic process
I6G56_RS02390	COG0667	Aldo Keto reductase
I6G56_RS02410	COG2814	Major facilitator Superfamily
I6G56_RS02425	COG0583	DNA-binding transcription factor activity
I6G56_RS02430	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G56_RS02440	COG2271	Major facilitator Superfamily
I6G56_RS02445	COG4948	Mandelate Racemase Muconate Lactonizing
I6G56_RS02455	COG2721	sulfolactate sulfo-lyase activity
I6G56_RS02460	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G56_RS02470	COG2271	Major facilitator Superfamily
I6G56_RS02480	COG1960	acyl-CoA dehydrogenase activity
I6G56_RS02540	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6G56_RS02550	COG0395	ABC-type sugar transport system, permease component
I6G56_RS02555	COG1175	transmembrane transport
I6G56_RS02570	COG3842	ATPase activity
I6G56_RS02575	COG1609	Transcriptional regulator
I6G56_RS02585	COG0531	amino acid
I6G56_RS02605	COG1280	lysine exporter protein (LysE YggA)
I6G56_RS02610	COG3568	Endonuclease Exonuclease Phosphatase
I6G56_RS02625	COG0579	oxidoreductase
I6G56_RS02645	COG0747	negative chemotaxis
I6G56_RS02650	COG0601	transmembrane transport
I6G56_RS02655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G56_RS02660	COG0444	Belongs to the ABC transporter superfamily
I6G56_RS02665	COG4608	Belongs to the ABC transporter superfamily
I6G56_RS02690	COG1984	allophanate hydrolase subunit 2
I6G56_RS02695	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6G56_RS02705	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G56_RS02710	COG0741	lytic transglycosylase activity
I6G56_RS02815	COG2747	anti-sigma28 factor FlgM
I6G56_RS02825	COG1815	bacterial-type flagellum-dependent cell motility
I6G56_RS02830	COG1558	bacterial-type flagellum-dependent cell motility
I6G56_RS02835	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6G56_RS02855	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
I6G56_RS02860	COG1706	bacterial-type flagellum-dependent cell motility
I6G56_RS02870	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6G56_RS02880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6G56_RS02885	COG2233	PERMEase
I6G56_RS02890	COG0583	DNA-binding transcription factor activity
I6G56_RS02910	COG2824	Alkylphosphonate utilization operon protein PhnA
I6G56_RS02920	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS03005	COG1704	LemA family
I6G56_RS03010	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6G56_RS03020	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6G56_RS03070	COG1609	Transcriptional regulator
I6G56_RS03075	COG0840	transmembrane signaling receptor activity
I6G56_RS03090	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS03095	COG0583	DNA-binding transcription factor activity
I6G56_RS03105	COG0596	Alpha beta hydrolase
I6G56_RS03135	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G56_RS03150	COG3511	phospholipase C
I6G56_RS03160	COG0583	DNA-binding transcription factor activity
I6G56_RS03165	COG0625	glutathione transferase activity
I6G56_RS03190	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G56_RS03230	COG0025	NhaP-type Na H and K H
I6G56_RS03235	COG2200	EAL domain
I6G56_RS03235	COG2199	diguanylate cyclase activity
I6G56_RS03255	COG1785	Belongs to the alkaline phosphatase family
I6G56_RS03300	COG3012	SEC-C Motif Domain Protein
I6G56_RS03310	COG0183	Belongs to the thiolase family
I6G56_RS03315	COG0288	reversible hydration of carbon dioxide
I6G56_RS03330	COG0747	negative chemotaxis
I6G56_RS03340	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS03345	COG0300	oxidoreductase activity
I6G56_RS03350	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G56_RS03370	COG1410	methionine synthase
I6G56_RS03370	COG0646	methionine synthase
I6G56_RS03400	COG1024	Enoyl-CoA hydratase
I6G56_RS03420	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6G56_RS03445	COG0737	Belongs to the 5'-nucleotidase family
I6G56_RS03450	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6G56_RS03455	COG1127	ABC transporter
I6G56_RS03485	COG1686	Belongs to the peptidase S11 family
I6G56_RS03490	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G56_RS03495	COG2921	Belongs to the UPF0250 family
I6G56_RS03500	COG0583	DNA-binding transcription factor activity
I6G56_RS03540	COG0583	DNA-binding transcription factor activity
I6G56_RS03545	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G56_RS03545	COG1024	Enoyl-CoA hydratase
I6G56_RS03550	COG1960	acyl-CoA dehydrogenase activity
I6G56_RS03555	COG1960	acyl-CoA dehydrogenase activity
I6G56_RS03560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G56_RS03570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G56_RS03580	COG4191	Histidine kinase
I6G56_RS03585	COG2204	response regulator
I6G56_RS03590	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G56_RS03620	COG2960	long-chain fatty acid transporting porin activity
I6G56_RS03630	COG0004	ammonium transporteR
I6G56_RS03640	COG0189	ligase activity
I6G56_RS03650	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G56_RS03655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G56_RS03660	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G56_RS03665	COG0793	Belongs to the peptidase S41A family
I6G56_RS03675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G56_RS03695	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6G56_RS03705	COG1040	competence protein
I6G56_RS03710	COG2226	methyltransferase
I6G56_RS03725	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G56_RS03730	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
I6G56_RS03760	COG1612	heme a metabolic process
I6G56_RS03770	COG1999	signal sequence binding
I6G56_RS03780	COG0840	transmembrane signaling receptor activity
I6G56_RS03805	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6G56_RS03810	COG0798	PFAM Bile acid sodium symporter
I6G56_RS03815	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G56_RS03830	COG0640	Transcriptional regulator
I6G56_RS03845	COG0587	DNA-directed DNA polymerase activity
I6G56_RS03850	COG2188	Transcriptional regulator
I6G56_RS03855	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G56_RS03860	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6G56_RS03865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G56_RS03865	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G56_RS03870	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G56_RS03870	COG2190	(PTS) system
I6G56_RS03870	COG1263	PTS System
I6G56_RS03885	COG2207	Transcriptional regulator
I6G56_RS03890	COG0300	oxidoreductase activity
I6G56_RS03900	COG1294	oxidase, subunit
I6G56_RS03915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G56_RS03920	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6G56_RS03930	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G56_RS03940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G56_RS03945	COG0243	molybdopterin cofactor binding
I6G56_RS03955	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G56_RS03960	COG0625	glutathione transferase activity
I6G56_RS03970	COG0742	ribosomal rna small subunit methyltransferase
I6G56_RS03980	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G56_RS04000	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G56_RS04015	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
I6G56_RS04030	COG1194	a g-specific adenine glycosylase
I6G56_RS04055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6G56_RS04060	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6G56_RS04065	COG1137	ATPase activity
I6G56_RS04080	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6G56_RS04100	COG1280	lysine exporter protein (LysE YggA)
I6G56_RS04125	COG2814	Major facilitator Superfamily
I6G56_RS04130	COG0629	single-stranded DNA binding
I6G56_RS04155	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G56_RS04200	COG5002	protein histidine kinase activity
I6G56_RS04200	COG5001	Diguanylate cyclase
I6G56_RS04240	COG2204	response regulator
I6G56_RS04260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6G56_RS04270	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G56_RS04285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G56_RS04345	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
I6G56_RS04350	COG0251	oxidation-reduction process
I6G56_RS04360	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G56_RS04425	COG0494	nUDIX hydrolase
I6G56_RS04440	COG1960	acyl-CoA dehydrogenase activity
I6G56_RS04445	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G56_RS04445	COG1024	Enoyl-CoA hydratase
I6G56_RS04450	COG0183	Belongs to the thiolase family
I6G56_RS04455	COG1024	Enoyl-CoA hydratase
I6G56_RS04460	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6G56_RS04475	COG5265	(ABC) transporter
I6G56_RS04485	COG3178	'Phosphotransferase
I6G56_RS04500	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6G56_RS04525	COG0204	Acyl-transferase
I6G56_RS04530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6G56_RS04535	COG0751	glycine-tRNA ligase activity
I6G56_RS04540	COG0752	glycyl-tRNA synthetase alpha subunit
I6G56_RS04545	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6G56_RS04550	COG4535	Mg2 and Co2 transporter CorC
I6G56_RS04560	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6G56_RS04570	COG1702	phosphate starvation-inducible protein PhoH
I6G56_RS04580	COG0583	DNA-binding transcription factor activity
I6G56_RS04585	COG2814	Major facilitator Superfamily
I6G56_RS04600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G56_RS04615	COG0367	asparagine synthase
I6G56_RS04620	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6G56_RS04625	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6G56_RS04640	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G56_RS04645	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6G56_RS04685	COG0513	Belongs to the DEAD box helicase family
I6G56_RS04705	COG4948	Mandelate Racemase Muconate Lactonizing
I6G56_RS04740	COG0840	transmembrane signaling receptor activity
I6G56_RS04755	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
I6G56_RS04815	COG0583	DNA-binding transcription factor activity
I6G56_RS04820	COG2205	protein histidine kinase activity
I6G56_RS04820	COG0784	Response regulator, receiver
I6G56_RS04850	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
I6G56_RS04870	COG0583	DNA-binding transcription factor activity
I6G56_RS04895	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6G56_RS04955	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6G56_RS04960	COG2137	regulation of response to DNA damage stimulus
I6G56_RS04975	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6G56_RS04980	COG0861	Integral membrane protein TerC family
I6G56_RS04985	COG4969	Belongs to the N-Me-Phe pilin family
I6G56_RS04990	COG3307	-O-antigen
I6G56_RS05005	COG0315	cyclic pyranopterin monophosphate synthase activity
I6G56_RS05010	COG4783	chaperone-mediated protein folding
I6G56_RS05020	COG0429	hydrolase of the alpha beta-hydrolase fold
I6G56_RS05030	COG0859	PFAM glycosyl transferase family 9
I6G56_RS05055	COG0126	phosphoglycerate kinase activity
I6G56_RS05060	COG0469	pyruvate kinase activity
I6G56_RS05070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
I6G56_RS05075	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6G56_RS05080	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6G56_RS05085	COG0009	L-threonylcarbamoyladenylate synthase
I6G56_RS05115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G56_RS05145	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G56_RS05150	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G56_RS05160	COG2233	PERMEase
I6G56_RS05165	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6G56_RS05180	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6G56_RS05185	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G56_RS05190	COG1121	(ABC) transporter
I6G56_RS05200	COG0735	belongs to the Fur family
I6G56_RS05210	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G56_RS05215	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
I6G56_RS05225	COG4209	transmembrane transport
I6G56_RS05235	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G56_RS05240	COG3842	ATPase activity
I6G56_RS05250	COG0583	DNA-binding transcription factor activity
I6G56_RS05265	COG2390	Transcriptional regulator
I6G56_RS05270	COG1070	Carbohydrate kinase
I6G56_RS05275	COG0246	Mannitol dehydrogenase
I6G56_RS05280	COG0583	DNA-binding transcription factor activity
I6G56_RS05290	COG1012	belongs to the aldehyde dehydrogenase family
I6G56_RS05305	COG2271	Major facilitator Superfamily
I6G56_RS05325	COG1522	sequence-specific DNA binding
I6G56_RS05330	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G56_RS05335	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6G56_RS05345	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6G56_RS05355	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6G56_RS05360	COG3118	belongs to the thioredoxin family
I6G56_RS05365	COG1741	Belongs to the pirin family
I6G56_RS05375	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G56_RS05380	COG0802	atpase or kinase
I6G56_RS05385	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6G56_RS05395	COG4974	Belongs to the 'phage' integrase family
I6G56_RS05400	COG0318	PFAM AMP-dependent synthetase and ligase
I6G56_RS05405	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G56_RS05425	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6G56_RS05440	COG0728	peptidoglycan biosynthetic process
I6G56_RS05470	COG1663	tetraacyldisaccharide 4'-kinase activity
I6G56_RS05475	COG1570	exodeoxyribonuclease VII activity
I6G56_RS05480	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G56_RS05510	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6G56_RS05525	COG2814	Major facilitator Superfamily
I6G56_RS05535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G56_RS05540	COG2188	Transcriptional regulator
I6G56_RS05545	COG0656	L-ascorbic acid biosynthetic process
I6G56_RS05565	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6G56_RS05595	COG1278	Cold shock
I6G56_RS05605	COG0542	response to heat
I6G56_RS05610	COG1113	amino acid transport
I6G56_RS05630	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G56_RS05645	COG0196	riboflavin kinase activity
I6G56_RS05650	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G56_RS05655	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I6G56_RS05655	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6G56_RS05660	COG3264	Mechanosensitive ion channel
I6G56_RS05660	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
I6G56_RS05680	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6G56_RS05700	COG1047	Peptidyl-prolyl cis-trans
I6G56_RS05705	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
I6G56_RS05740	COG0456	acetyltransferase
I6G56_RS05745	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G56_RS05750	COG0543	2 iron, 2 sulfur cluster binding
I6G56_RS05750	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G56_RS05765	COG1187	pseudouridine synthase activity
I6G56_RS05775	COG0583	DNA-binding transcription factor activity
I6G56_RS05795	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G56_RS05800	COG0235	Class ii aldolase
I6G56_RS05805	COG1396	sequence-specific DNA binding
I6G56_RS05850	COG0583	DNA-binding transcription factor activity
I6G56_RS05865	COG0175	sulfate reduction
I6G56_RS05875	COG2895	sulfate adenylyltransferase (ATP) activity
I6G56_RS05880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6G56_RS05880	COG1648	precorrin-2 dehydrogenase activity
I6G56_RS05895	COG0795	lipopolysaccharide-transporting ATPase activity
I6G56_RS05915	COG4654	Cytochrome c, class I
I6G56_RS05925	COG0583	DNA-binding transcription factor activity
I6G56_RS05960	COG4206	TonB-dependent receptor
I6G56_RS05970	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6G56_RS05975	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6G56_RS05980	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
I6G56_RS05990	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G56_RS06000	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
I6G56_RS06010	COG1492	cobalamin metabolic process
I6G56_RS06015	COG2259	Doxx family
I6G56_RS06020	COG0489	protein tyrosine kinase activity
I6G56_RS06040	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I6G56_RS06050	COG0729	surface antigen
I6G56_RS06055	COG2911	Protein conserved in bacteria
I6G56_RS06085	COG0489	protein tyrosine kinase activity
I6G56_RS06110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G56_RS06125	COG2226	methyltransferase
I6G56_RS06150	COG2271	Major facilitator Superfamily
I6G56_RS06165	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6G56_RS06170	COG2827	Endonuclease containing a URI domain
I6G56_RS06195	COG0347	Belongs to the P(II) protein family
I6G56_RS06215	COG4215	(ABC) transporter
I6G56_RS06225	COG1741	Belongs to the pirin family
I6G56_RS06250	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G56_RS06255	COG1116	anion transmembrane transporter activity
I6G56_RS06275	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6G56_RS06290	COG2814	Major facilitator Superfamily
I6G56_RS06295	COG1881	PFAM PEBP family protein
I6G56_RS06345	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6G56_RS06400	COG0582	viral genome integration into host DNA
I6G56_RS06460	COG1773	rubredoxin
I6G56_RS06470	COG0488	(ABC) transporter
I6G56_RS06490	COG0583	DNA-binding transcription factor activity
I6G56_RS06500	COG0583	DNA-binding transcription factor activity
I6G56_RS06505	COG0477	Major facilitator Superfamily
I6G56_RS06540	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G56_RS06545	COG0697	spore germination
I6G56_RS06555	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G56_RS06585	COG4106	trans-aconitate 2-methyltransferase activity
I6G56_RS06600	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6G56_RS06610	COG3135	benzoate transporter
I6G56_RS06645	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G56_RS06650	COG2878	Part of a membrane complex involved in electron transport
I6G56_RS06655	COG1309	transcriptional regulator
I6G56_RS06665	COG3387	PFAM Glycoside hydrolase 15-related
I6G56_RS06670	COG2706	6-phosphogluconolactonase activity
I6G56_RS06715	COG0513	Belongs to the DEAD box helicase family
I6G56_RS06720	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G56_RS06755	COG0438	transferase activity, transferring glycosyl groups
I6G56_RS06760	COG0859	PFAM glycosyl transferase family 9
I6G56_RS06790	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G56_RS06795	COG1595	DNA-templated transcription, initiation
I6G56_RS06800	COG0583	DNA-binding transcription factor activity
I6G56_RS06840	COG2233	PERMEase
I6G56_RS06875	COG0799	negative regulation of ribosome biogenesis
I6G56_RS06890	COG0151	Belongs to the GarS family
I6G56_RS06905	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS06925	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6G56_RS06930	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
I6G56_RS06940	COG2205	protein histidine kinase activity
I6G56_RS06945	COG0745	RESPONSE REGULATOR receiver
I6G56_RS06955	COG2076	Multidrug Resistance protein
I6G56_RS06975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G56_RS06985	COG0154	amidase activity
I6G56_RS06995	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6G56_RS07000	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS07020	COG0438	transferase activity, transferring glycosyl groups
I6G56_RS07050	COG0028	Belongs to the TPP enzyme family
I6G56_RS07070	COG1183	phosphatidylcholine synthase activity
I6G56_RS07080	COG0659	secondary active sulfate transmembrane transporter activity
I6G56_RS07085	COG0288	reversible hydration of carbon dioxide
I6G56_RS07095	COG0683	leucine binding
I6G56_RS07110	COG3321	synthase
I6G56_RS07110	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G56_RS07110	COG0604	alcohol dehydrogenase
I6G56_RS07110	COG4221	oxidoreductase activity
I6G56_RS07115	COG0149	triose-phosphate isomerase activity
I6G56_RS07150	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6G56_RS07160	COG1034	ATP synthesis coupled electron transport
I6G56_RS07195	COG1007	ATP synthesis coupled electron transport
I6G56_RS07205	COG0494	nUDIX hydrolase
I6G56_RS07215	COG1960	acyl-CoA dehydrogenase activity
I6G56_RS07220	COG1960	acyl-CoA dehydrogenase activity
I6G56_RS07225	COG2030	dehydratase
I6G56_RS07225	COG1012	belongs to the aldehyde dehydrogenase family
I6G56_RS07240	COG1960	acyl-CoA dehydrogenase activity
I6G56_RS07250	COG0588	phosphoglycerate mutase activity
I6G56_RS07255	COG1024	Enoyl-CoA hydratase
I6G56_RS07265	COG0436	Aminotransferase
I6G56_RS07280	COG2866	Carboxypeptidase
I6G56_RS07335	COG0006	proline dipeptidase activity
I6G56_RS07350	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G56_RS07370	COG2863	cytochrome
I6G56_RS07375	COG2010	Cytochrome c
I6G56_RS07375	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6G56_RS07390	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G56_RS07405	COG2203	Gaf domain
I6G56_RS07405	COG3706	GGDEF domain
I6G56_RS07405	COG4251	negative regulation of phosphorylation
I6G56_RS07405	COG5001	Diguanylate cyclase
I6G56_RS07420	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G56_RS07425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G56_RS07430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G56_RS07445	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G56_RS07455	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6G56_RS07460	COG2086	electron transfer activity
I6G56_RS07465	COG2070	2-Nitropropane dioxygenase
I6G56_RS07490	COG1126	abc transporter atp-binding protein
I6G56_RS07495	COG4215	(ABC) transporter
I6G56_RS07500	COG0765	amino acid transport
I6G56_RS07515	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS07525	COG2030	dehydratase
I6G56_RS07525	COG1012	belongs to the aldehyde dehydrogenase family
I6G56_RS07530	COG0318	PFAM AMP-dependent synthetase and ligase
I6G56_RS07535	COG3153	acetyltransferase
I6G56_RS07535	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G56_RS07580	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G56_RS07585	COG3971	2-oxopent-4-enoate hydratase activity
I6G56_RS07590	COG4569	acetaldehyde dehydrogenase (acetylating) activity
I6G56_RS07595	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6G56_RS07605	COG1902	pentaerythritol trinitrate reductase activity
I6G56_RS07605	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G56_RS07610	COG3047	cAMP biosynthetic process
I6G56_RS07625	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G56_RS07630	COG0318	PFAM AMP-dependent synthetase and ligase
I6G56_RS07650	COG2706	6-phosphogluconolactonase activity
I6G56_RS07660	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS07705	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS07725	COG1012	belongs to the aldehyde dehydrogenase family
I6G56_RS07730	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS07735	COG1522	sequence-specific DNA binding
I6G56_RS07745	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G56_RS07760	COG0583	DNA-binding transcription factor activity
I6G56_RS07840	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G56_RS07910	COG1396	sequence-specific DNA binding
I6G56_RS07915	COG4771	TonB-dependent receptor
I6G56_RS07920	COG4166	transmembrane transport
I6G56_RS07925	COG4174	ABC transporter (Permease)
I6G56_RS07930	COG4239	(ABC) transporter, permease
I6G56_RS07935	COG4172	Belongs to the ABC transporter superfamily
I6G56_RS08025	COG1959	2 iron, 2 sulfur cluster binding
I6G56_RS08030	COG2910	NAD(P)H-binding
I6G56_RS08035	COG0668	transmembrane transport
I6G56_RS08050	COG1522	sequence-specific DNA binding
I6G56_RS08055	COG3842	ATPase activity
I6G56_RS08060	COG1178	ABC-type Fe3 transport system permease component
I6G56_RS08065	COG1840	ABC-type Fe3 transport system, periplasmic component
I6G56_RS08085	COG1289	transmembrane transporter activity
I6G56_RS08090	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6G56_RS08100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G56_RS08110	COG2203	Gaf domain
I6G56_RS08110	COG2200	EAL domain
I6G56_RS08110	COG2199	diguanylate cyclase activity
I6G56_RS08150	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6G56_RS08155	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6G56_RS08160	COG0697	spore germination
I6G56_RS08165	COG2814	Major facilitator Superfamily
I6G56_RS08180	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6G56_RS08185	COG3842	ATPase activity
I6G56_RS08190	COG1177	transmembrane transport
I6G56_RS08205	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6G56_RS08215	COG1609	Transcriptional regulator
I6G56_RS08270	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G56_RS08275	COG1522	sequence-specific DNA binding
I6G56_RS08295	COG0640	Transcriptional regulator
I6G56_RS08310	COG0583	DNA-binding transcription factor activity
I6G56_RS08325	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G56_RS08365	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6G56_RS08370	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G56_RS08380	COG0583	DNA-binding transcription factor activity
I6G56_RS08400	COG3052	prosthetic group binding
I6G56_RS08420	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
I6G56_RS08455	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G56_RS08460	COG0328	RNA-DNA hybrid ribonuclease activity
I6G56_RS08465	COG2226	methyltransferase
I6G56_RS08470	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G56_RS08475	COG0741	lytic transglycosylase activity
I6G56_RS08475	COG1388	LysM domain
I6G56_RS08485	COG0505	Belongs to the CarA family
I6G56_RS08495	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6G56_RS08500	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G56_RS08510	COG1534	Rna-binding protein
I6G56_RS08520	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G56_RS08525	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G56_RS08535	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6G56_RS08540	COG0573	inorganic phosphate transmembrane transporter activity
I6G56_RS08545	COG0581	inorganic phosphate transmembrane transporter activity
I6G56_RS08560	COG0745	RESPONSE REGULATOR receiver
I6G56_RS08570	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6G56_RS08625	COG0534	Mate efflux family protein
I6G56_RS08635	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G56_RS08640	COG4942	peptidase
I6G56_RS08665	COG3344	reverse transcriptase
I6G56_RS08875	COG3772	lysozyme
I6G56_RS08895	COG0583	DNA-binding transcription factor activity
I6G56_RS08905	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6G56_RS08935	COG3008	intermembrane lipid transfer
I6G56_RS08955	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G56_RS08975	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G56_RS08980	COG1960	acyl-CoA dehydrogenase activity
I6G56_RS08985	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
I6G56_RS09015	COG2814	Major facilitator Superfamily
I6G56_RS09020	COG0583	DNA-binding transcription factor activity
I6G56_RS09070	COG2197	response regulator
I6G56_RS09080	COG3511	phospholipase C
I6G56_RS09085	COG1858	cytochrome C peroxidase
I6G56_RS09105	COG1051	belongs to the nudix hydrolase family
I6G56_RS09110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6G56_RS09125	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G56_RS09145	COG0477	Major facilitator Superfamily
I6G56_RS09150	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G56_RS09155	COG0494	nUDIX hydrolase
I6G56_RS09170	COG0824	Thioesterase
I6G56_RS09190	COG3718	enzyme involved in inositol metabolism
I6G56_RS09200	COG3962	Belongs to the TPP enzyme family
I6G56_RS09205	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G56_RS09215	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G56_RS09230	COG0673	inositol 2-dehydrogenase activity
I6G56_RS09235	COG0673	inositol 2-dehydrogenase activity
I6G56_RS09240	COG0425	Belongs to the sulfur carrier protein TusA family
I6G56_RS09255	COG0745	RESPONSE REGULATOR receiver
I6G56_RS09265	COG5002	protein histidine kinase activity
I6G56_RS09280	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G56_RS09285	COG0525	valine-tRNA ligase activity
I6G56_RS09290	COG0210	DNA helicase
I6G56_RS09295	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G56_RS09300	COG2223	nitrite transmembrane transporter activity
I6G56_RS09305	COG0840	transmembrane signaling receptor activity
I6G56_RS09330	COG0583	DNA-binding transcription factor activity
I6G56_RS09345	COG0277	FAD linked oxidase domain protein
I6G56_RS09360	COG1295	ribonuclease BN
I6G56_RS09375	COG0477	Major facilitator Superfamily
I6G56_RS09390	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS09425	COG2267	carboxylic ester hydrolase activity
I6G56_RS09430	COG0251	oxidation-reduction process
I6G56_RS09435	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G56_RS09450	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I6G56_RS09475	COG0776	regulation of translation
I6G56_RS09525	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6G56_RS09565	COG0583	DNA-binding transcription factor activity
I6G56_RS09570	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6G56_RS09575	COG1187	pseudouridine synthase activity
I6G56_RS09585	COG0195	Participates in both transcription termination and antitermination
I6G56_RS09585	COG2251	uridine kinase activity
I6G56_RS09600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6G56_RS09605	COG2814	Major facilitator Superfamily
I6G56_RS09610	COG1566	PFAM secretion protein HlyD family protein
I6G56_RS09620	COG1846	Transcriptional regulator
I6G56_RS09625	COG1217	gtp-binding protein TYPA
I6G56_RS09630	COG0567	Dehydrogenase, E1 component
I6G56_RS09635	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G56_RS09640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G56_RS09645	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6G56_RS09695	COG4964	Belongs to the GSP D family
I6G56_RS09745	COG1923	regulation of RNA biosynthetic process
I6G56_RS09760	COG0318	PFAM AMP-dependent synthetase and ligase
I6G56_RS09770	COG2814	Major facilitator Superfamily
I6G56_RS09775	COG0519	Catalyzes the synthesis of GMP from XMP
I6G56_RS09805	COG0745	RESPONSE REGULATOR receiver
I6G56_RS09820	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G56_RS09825	COG1609	Transcriptional regulator
I6G56_RS09830	COG3842	ATPase activity
I6G56_RS09840	COG1175	transmembrane transport
I6G56_RS09845	COG0395	ABC-type sugar transport system, permease component
I6G56_RS09855	COG2814	Major facilitator Superfamily
I6G56_RS09880	COG0557	exoribonuclease II activity
I6G56_RS09885	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G56_RS09890	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G56_RS09900	COG1802	Transcriptional regulator
I6G56_RS09905	COG0673	inositol 2-dehydrogenase activity
I6G56_RS09910	COG0765	amino acid transport
I6G56_RS09915	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G56_RS09970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G56_RS10000	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G56_RS10005	COG1301	dicarboxylic acid transport
I6G56_RS10020	COG0667	Aldo Keto reductase
I6G56_RS10025	COG0701	Predicted permease
I6G56_RS10065	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6G56_RS10070	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6G56_RS10075	COG4208	sulfate ABC transporter
I6G56_RS10080	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6G56_RS10085	COG0583	DNA-binding transcription factor activity
I6G56_RS10090	COG1879	ABC-type sugar transport system periplasmic component
I6G56_RS10095	COG1129	ABC transporter
I6G56_RS10100	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G56_RS10105	COG1609	Transcriptional regulator
I6G56_RS10110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G56_RS10115	COG0840	transmembrane signaling receptor activity
I6G56_RS10125	COG2766	serine protein kinase
I6G56_RS10130	COG2718	Belongs to the UPF0229 family
I6G56_RS10135	COG2719	SpoVR family
I6G56_RS10140	COG0477	Major facilitator Superfamily
I6G56_RS10150	COG3344	reverse transcriptase
I6G56_RS10180	COG4964	Belongs to the GSP D family
I6G56_RS10225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G56_RS10230	COG0765	amino acid transport
I6G56_RS10235	COG0765	amino acid transport
I6G56_RS10240	COG0739	heme binding
I6G56_RS10245	COG1309	transcriptional regulator
I6G56_RS10255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G56_RS10265	COG1132	(ABC) transporter
I6G56_RS10290	COG1879	ABC-type sugar transport system periplasmic component
I6G56_RS10305	COG1063	alcohol dehydrogenase
I6G56_RS10315	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS10340	COG1120	ATPase activity
I6G56_RS10385	COG3486	L-lysine 6-monooxygenase (NADPH) activity
I6G56_RS10390	COG4774	siderophore transport
I6G56_RS10395	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G56_RS10425	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
I6G56_RS10460	COG3979	chitinase
I6G56_RS10480	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G56_RS10505	COG1649	PFAM Uncharacterised BCR, COG1649
I6G56_RS10510	COG2807	transmembrane transport
I6G56_RS10515	COG1846	Transcriptional regulator
I6G56_RS10575	COG0625	glutathione transferase activity
I6G56_RS10580	COG0583	DNA-binding transcription factor activity
I6G56_RS10600	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6G56_RS10605	COG2235	arginine
I6G56_RS10620	COG1174	glycine betaine transport
I6G56_RS10625	COG1125	glycine betaine transport
I6G56_RS10630	COG1174	glycine betaine transport
I6G56_RS10635	COG1732	Glycine betaine
I6G56_RS10640	COG2226	methyltransferase
I6G56_RS10655	COG0318	PFAM AMP-dependent synthetase and ligase
I6G56_RS10665	COG0835	chemotaxis
I6G56_RS10725	COG3547	Transposase (IS116 IS110 IS902 family)
I6G56_RS10750	COG4771	TonB-dependent receptor
I6G56_RS10770	COG4166	transmembrane transport
I6G56_RS10775	COG4174	ABC transporter (Permease)
I6G56_RS10780	COG4239	(ABC) transporter, permease
I6G56_RS10785	COG4172	Belongs to the ABC transporter superfamily
I6G56_RS10850	COG4669	(LipO)protein
I6G56_RS10900	COG2197	response regulator
I6G56_RS10905	COG2205	protein histidine kinase activity
I6G56_RS10905	COG3850	Histidine kinase
I6G56_RS10905	COG3437	response regulator, receiver
I6G56_RS10905	COG4999	Histidine kinase
I6G56_RS10960	COG1196	nuclear chromosome segregation
I6G56_RS10960	COG0741	lytic transglycosylase activity
I6G56_RS10960	COG0739	heme binding
I6G56_RS10985	COG0642	Histidine kinase
I6G56_RS10990	COG0745	RESPONSE REGULATOR receiver
I6G56_RS10995	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G56_RS11000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G56_RS11030	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G56_RS11035	COG0297	glycogen (starch) synthase activity
I6G56_RS11045	COG0438	transferase activity, transferring glycosyl groups
I6G56_RS11075	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6G56_RS11080	COG0438	transferase activity, transferring glycosyl groups
I6G56_RS11085	COG0438	transferase activity, transferring glycosyl groups
I6G56_RS11085	COG0297	glycogen (starch) synthase activity
I6G56_RS11090	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G56_RS11095	COG0367	asparagine synthase
I6G56_RS11105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G56_RS11120	COG2207	Transcriptional regulator
I6G56_RS11135	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G56_RS11140	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G56_RS11145	COG1129	ABC transporter
I6G56_RS11150	COG1879	ABC-type sugar transport system periplasmic component
I6G56_RS11155	COG4214	carbohydrate transport
I6G56_RS11165	COG4213	ABC transporter substrate-binding protein
I6G56_RS11175	COG2207	Transcriptional regulator
I6G56_RS11175	COG1609	Transcriptional regulator
I6G56_RS11180	COG2017	converts alpha-aldose to the beta-anomer
I6G56_RS11195	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G56_RS11210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G56_RS11335	COG1454	alcohol dehydrogenase
I6G56_RS11380	COG0475	glutathione-regulated potassium exporter activity
I6G56_RS11395	COG2376	Dihydroxyacetone kinase
I6G56_RS11410	COG1196	nuclear chromosome segregation
I6G56_RS11410	COG3264	Mechanosensitive ion channel
I6G56_RS11430	COG0598	Magnesium transport protein CorA
I6G56_RS11470	COG0402	S-adenosylhomocysteine deaminase activity
I6G56_RS11495	COG2205	protein histidine kinase activity
I6G56_RS11495	COG0784	Response regulator, receiver
I6G56_RS11550	COG1609	Transcriptional regulator
I6G56_RS11555	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G56_RS11565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G56_RS11580	COG2855	membrane
I6G56_RS11585	COG0038	chloride channel
I6G56_RS11600	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G56_RS11605	COG1538	Outer membrane efflux protein
I6G56_RS11610	COG0789	Transcriptional regulator
I6G56_RS11615	COG2211	Major facilitator Superfamily
I6G56_RS11620	COG3655	Transcriptional regulator
I6G56_RS11650	COG1177	transmembrane transport
I6G56_RS11655	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G56_RS11660	COG3842	ATPase activity
I6G56_RS11665	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6G56_RS11670	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G56_RS11680	COG3047	cAMP biosynthetic process
I6G56_RS11685	COG2070	2-Nitropropane dioxygenase
I6G56_RS11775	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6G56_RS11785	COG0488	(ABC) transporter
I6G56_RS11790	COG2982	Protein involved in outer membrane biogenesis
I6G56_RS11795	COG1122	ATPase activity
I6G56_RS11800	COG0390	transport system, permease component
I6G56_RS11810	COG0560	Phosphoserine phosphatase
I6G56_RS11815	COG0626	cystathionine gamma-synthase activity
I6G56_RS11825	COG0183	Belongs to the thiolase family
I6G56_RS11845	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS11850	COG0183	Belongs to the thiolase family
I6G56_RS11855	COG3243	poly(R)-hydroxyalkanoic acid synthase
I6G56_RS11865	COG0564	pseudouridine synthase activity
I6G56_RS11875	COG1199	ATP-dependent helicase activity
I6G56_RS11890	COG2183	response to ionizing radiation
I6G56_RS11910	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6G56_RS11925	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6G56_RS11930	COG0330	HflC and HflK could
I6G56_RS11935	COG0330	HflC and HflK could
I6G56_RS11940	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G56_RS11955	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G56_RS11990	COG0670	Belongs to the BI1 family
I6G56_RS12030	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G56_RS12045	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6G56_RS12060	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6G56_RS12065	COG0789	Transcriptional regulator
I6G56_RS12075	COG3228	Belongs to the MtfA family
I6G56_RS12090	COG0534	Mate efflux family protein
I6G56_RS12100	COG0022	dehydrogenase e1 component
I6G56_RS12105	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
I6G56_RS12115	COG3199	ATP-NAD kinase
I6G56_RS12120	COG3284	Transcriptional regulator
I6G56_RS12150	COG3547	Transposase (IS116 IS110 IS902 family)
I6G56_RS12160	COG0542	response to heat
I6G56_RS12165	COG1959	2 iron, 2 sulfur cluster binding
I6G56_RS12170	COG2346	COG2346, Truncated hemoglobins
I6G56_RS12175	COG0314	molybdopterin synthase activity
I6G56_RS12180	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6G56_RS12200	COG0436	Aminotransferase
I6G56_RS12215	COG2076	Multidrug Resistance protein
I6G56_RS12220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G56_RS12225	COG0463	Glycosyl transferase, family 2
I6G56_RS12235	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6G56_RS12235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G56_RS12240	COG0726	polysaccharide deacetylase
I6G56_RS12245	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6G56_RS12255	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6G56_RS12260	COG0791	NLP P60 protein
I6G56_RS12265	COG0306	phosphate transporter
I6G56_RS12305	COG1595	DNA-templated transcription, initiation
I6G56_RS12320	COG0583	DNA-binding transcription factor activity
I6G56_RS12325	COG3960	tartronate-semialdehyde synthase activity
I6G56_RS12330	COG3622	Belongs to the hyi family
I6G56_RS12335	COG2084	Dehydrogenase
I6G56_RS12345	COG1652	LysM domain
I6G56_RS12350	COG0252	asparaginase activity
I6G56_RS12370	COG0438	transferase activity, transferring glycosyl groups
I6G56_RS12395	COG0084	hydrolase, TatD family'
I6G56_RS12400	COG1247	-acetyltransferase
I6G56_RS12415	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G56_RS12435	COG0657	acetylesterase activity
I6G56_RS12440	COG2130	NADP-dependent
I6G56_RS12460	COG0183	Belongs to the thiolase family
I6G56_RS12465	COG1335	isochorismatase
I6G56_RS12470	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G56_RS12470	COG1024	Enoyl-CoA hydratase
I6G56_RS12475	COG0318	PFAM AMP-dependent synthetase and ligase
I6G56_RS12500	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G56_RS12505	COG0047	phosphoribosylformylglycinamidine synthase activity
I6G56_RS12505	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G56_RS12510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G56_RS12525	COG4181	ATPase activity
I6G56_RS12535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G56_RS12575	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6G56_RS12595	COG1929	Belongs to the glycerate kinase type-1 family
I6G56_RS12600	COG1846	Transcriptional regulator
I6G56_RS12605	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6G56_RS12685	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G56_RS12700	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G56_RS12760	COG3360	Dodecin
I6G56_RS12775	COG2351	hydroxyisourate hydrolase activity
I6G56_RS12800	COG4266	Belongs to the allantoicase family
I6G56_RS12805	COG3648	Uricase
I6G56_RS12805	COG3195	allantoin biosynthetic process
I6G56_RS12820	COG1953	Uracil, thiamine, allantoin
I6G56_RS12830	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6G56_RS12850	COG2814	Major facilitator Superfamily
I6G56_RS12855	COG2207	Transcriptional regulator
I6G56_RS12890	COG4942	peptidase
I6G56_RS12895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G56_RS12935	COG0697	spore germination
I6G56_RS12955	COG0330	HflC and HflK could
I6G56_RS12980	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G56_RS13020	COG0750	zinc metalloprotease
I6G56_RS13035	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G56_RS13040	COG0233	cytoplasmic translational termination
I6G56_RS13060	COG0024	Methionine aminopeptidase
I6G56_RS13070	COG1187	pseudouridine synthase activity
I6G56_RS13075	COG0242	peptide deformylase activity
I6G56_RS13110	COG1393	Belongs to the ArsC family
I6G56_RS13120	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G56_RS13130	COG0386	Belongs to the glutathione peroxidase family
I6G56_RS13135	COG0488	(ABC) transporter
I6G56_RS13155	COG0477	Major facilitator Superfamily
I6G56_RS13160	COG0351	phosphomethylpyrimidine kinase
I6G56_RS13170	COG1573	uracil-dna glycosylase
I6G56_RS13180	COG1214	PFAM Peptidase M22, glycoprotease
I6G56_RS13190	COG0513	Belongs to the DEAD box helicase family
I6G56_RS13195	COG2224	Isocitrate lyase
I6G56_RS13205	COG0583	DNA-binding transcription factor activity
I6G56_RS13215	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6G56_RS13270	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6G56_RS13275	COG0791	NLP P60 protein
I6G56_RS13280	COG4172	Belongs to the ABC transporter superfamily
I6G56_RS13285	COG4239	(ABC) transporter, permease
I6G56_RS13290	COG4174	ABC transporter (Permease)
I6G56_RS13295	COG4166	transmembrane transport
I6G56_RS13310	COG3383	formate dehydrogenase (NAD+) activity
I6G56_RS13320	COG0024	Methionine aminopeptidase
I6G56_RS13340	COG2267	carboxylic ester hydrolase activity
I6G56_RS13345	COG1309	transcriptional regulator
I6G56_RS13380	COG0527	aspartate kinase activity
I6G56_RS13390	COG0037	tRNA processing
I6G56_RS13415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G56_RS13425	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G56_RS13430	COG1045	serine acetyltransferase
I6G56_RS13440	COG0483	inositol monophosphate 1-phosphatase activity
I6G56_RS13455	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I6G56_RS13470	COG2850	peptidyl-arginine hydroxylation
I6G56_RS13475	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6G56_RS13480	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6G56_RS13485	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G56_RS13495	COG0180	Tryptophanyl-tRNA synthetase
I6G56_RS13500	COG1994	Peptidase M50
I6G56_RS13505	COG0009	L-threonylcarbamoyladenylate synthase
I6G56_RS13510	COG0613	PHP domain protein
I6G56_RS13515	COG0596	Alpha beta hydrolase
I6G56_RS13520	COG2833	Protein of unknown function (DUF455)
I6G56_RS13530	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I6G56_RS13540	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
I6G56_RS13560	COG3547	Transposase (IS116 IS110 IS902 family)
I6G56_RS13565	COG2267	carboxylic ester hydrolase activity
I6G56_RS13570	COG2333	competence protein COMEC
I6G56_RS13570	COG0658	competence protein
I6G56_RS13575	COG0084	hydrolase, TatD family'
I6G56_RS13595	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6G56_RS13635	COG0316	Belongs to the HesB IscA family
I6G56_RS13640	COG0822	iron-sulfur transferase activity
I6G56_RS13645	COG1104	cysteine desulfurase activity
I6G56_RS13655	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G56_RS13675	COG1414	Transcriptional regulator
I6G56_RS13690	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G56_RS13695	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G56_RS13700	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6G56_RS13715	COG4566	intracellular signal transduction
I6G56_RS13725	COG0339	signal peptide processing
I6G56_RS13730	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G56_RS13750	COG2223	nitrite transmembrane transporter activity
I6G56_RS13755	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6G56_RS13760	COG1140	nitrate reductase beta subunit
I6G56_RS13765	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6G56_RS13770	COG2181	nitrate reductase activity
I6G56_RS13775	COG4585	Histidine kinase
I6G56_RS13780	COG2197	response regulator
I6G56_RS13805	COG0174	glutamine synthetase
I6G56_RS13815	COG1058	Belongs to the CinA family
I6G56_RS13815	COG1546	Belongs to the CinA family
I6G56_RS13835	COG1643	Atp-dependent helicase
I6G56_RS13840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6G56_RS13840	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6G56_RS13850	COG0477	Major facilitator Superfamily
I6G56_RS13860	COG1960	acyl-CoA dehydrogenase activity
I6G56_RS13865	COG0583	DNA-binding transcription factor activity
I6G56_RS13890	COG0174	glutamine synthetase
I6G56_RS13895	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6G56_RS13910	COG0402	S-adenosylhomocysteine deaminase activity
I6G56_RS13925	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6G56_RS13955	COG0529	Catalyzes the synthesis of activated sulfate
I6G56_RS13975	COG2151	metal-sulfur cluster biosynthetic enzyme
I6G56_RS14010	COG3154	lipid carrier protein
I6G56_RS14015	COG0826	peptidase U32
I6G56_RS14020	COG0826	peptidase U32
I6G56_RS14035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G56_RS14040	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G56_RS14045	COG0840	transmembrane signaling receptor activity
I6G56_RS14055	COG0719	Fe-S assembly protein
I6G56_RS14060	COG0396	ATPase activity
I6G56_RS14070	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G56_RS14075	COG0822	iron-sulfur transferase activity
I6G56_RS14080	COG2151	metal-sulfur cluster biosynthetic enzyme
I6G56_RS14090	COG1959	2 iron, 2 sulfur cluster binding
I6G56_RS14095	COG2703	oxygen carrier activity
I6G56_RS14115	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6G56_RS14135	COG0625	glutathione transferase activity
I6G56_RS14165	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G56_RS14175	COG4598	ABC transporter
I6G56_RS14200	COG3394	polysaccharide catabolic process
I6G56_RS14205	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G56_RS14215	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G56_RS14220	COG0596	Alpha beta hydrolase
I6G56_RS14225	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6G56_RS14230	COG3511	phospholipase C
I6G56_RS14235	COG0683	leucine binding
I6G56_RS14240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G56_RS14255	COG0438	transferase activity, transferring glycosyl groups
I6G56_RS14260	COG1132	(ABC) transporter
I6G56_RS14265	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6G56_RS14275	COG1999	signal sequence binding
I6G56_RS14305	COG1956	GAF domain-containing protein
I6G56_RS14330	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G56_RS14335	COG0322	excinuclease ABC activity
I6G56_RS14365	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6G56_RS14375	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I6G56_RS14380	COG0571	ribonuclease III activity
I6G56_RS14385	COG0681	Belongs to the peptidase S26 family
I6G56_RS14400	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G56_RS14405	COG3026	antisigma factor binding
I6G56_RS14425	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G56_RS14475	COG0616	signal peptide processing
I6G56_RS14485	COG0546	phosphoglycolate phosphatase activity
I6G56_RS14495	COG1530	ribonuclease E activity
I6G56_RS14500	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G56_RS14545	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6G56_RS14550	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6G56_RS14565	COG3045	CreA protein
I6G56_RS14575	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6G56_RS14595	COG2501	S4 domain
I6G56_RS14600	COG0534	Mate efflux family protein
I6G56_RS14605	COG0114	fumarate hydratase activity
I6G56_RS14620	COG0640	Transcriptional regulator
I6G56_RS14630	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6G56_RS14655	COG2204	response regulator
I6G56_RS14665	COG0312	modulator of DNA gyrase
I6G56_RS14670	COG3028	Belongs to the UPF0307 family
I6G56_RS14675	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G56_RS14685	COG0501	Belongs to the peptidase M48B family
I6G56_RS14705	COG0494	nUDIX hydrolase
I6G56_RS14790	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6G56_RS14805	COG1196	nuclear chromosome segregation
I6G56_RS14810	COG4974	Belongs to the 'phage' integrase family
I6G56_RS14845	COG3344	reverse transcriptase
I6G56_RS14850	COG1960	acyl-CoA dehydrogenase activity
I6G56_RS14865	COG1464	Belongs to the NlpA lipoprotein family
I6G56_RS14870	COG2011	ABC-type metal ion transport system permease component
I6G56_RS14880	COG2267	carboxylic ester hydrolase activity
I6G56_RS14885	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6G56_RS14890	COG2951	lytic endotransglycosylase activity
I6G56_RS14910	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6G56_RS14920	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6G56_RS14945	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6G56_RS14950	COG1605	Chorismate mutase
I6G56_RS14950	COG0077	Prephenate dehydratase
I6G56_RS14955	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
I6G56_RS14980	COG0546	phosphoglycolate phosphatase activity
I6G56_RS15130	COG4383	Mu-like prophage protein gp29
I6G56_RS15145	COG4388	Caudovirus prohead serine protease
I6G56_RS15155	COG4397	Mu-like prophage major head subunit gpT
I6G56_RS15165	COG4387	Mu-like prophage protein GP36
I6G56_RS15180	COG4386	tail sheath protein
I6G56_RS15250	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6G56_RS15260	COG1910	domain protein
I6G56_RS15275	COG3383	formate dehydrogenase (NAD+) activity
I6G56_RS15300	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6G56_RS15320	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
I6G56_RS15325	COG2252	PERMEase
I6G56_RS15330	COG0402	S-adenosylhomocysteine deaminase activity
I6G56_RS15335	COG2119	membrane
I6G56_RS15345	COG0308	aminopeptidase N
I6G56_RS15355	COG0583	DNA-binding transcription factor activity
I6G56_RS15385	COG4772	TonB-dependent receptor
I6G56_RS15405	COG2176	DNA-directed DNA polymerase activity
I6G56_RS15410	COG1278	Cold shock
I6G56_RS15420	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS15445	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G56_RS15460	COG1561	YicC-like family, N-terminal region
I6G56_RS15470	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6G56_RS15475	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G56_RS15505	COG0477	Major facilitator Superfamily
I6G56_RS15515	COG0859	PFAM glycosyl transferase family 9
I6G56_RS15535	COG2894	cell division
I6G56_RS15575	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G56_RS15580	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
I6G56_RS15585	COG1674	ftsk spoiiie
I6G56_RS15590	COG0492	ferredoxin-NADP+ reductase activity
I6G56_RS15595	COG1193	negative regulation of DNA recombination
I6G56_RS15600	COG3842	ATPase activity
I6G56_RS15605	COG0395	ABC-type sugar transport system, permease component
I6G56_RS15610	COG1175	transmembrane transport
I6G56_RS15620	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6G56_RS15625	COG0363	glucosamine-6-phosphate deaminase activity
I6G56_RS15630	COG1737	Transcriptional regulator
I6G56_RS15630	COG0837	glucose binding
I6G56_RS15645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G56_RS15650	COG0765	amino acid transport
I6G56_RS15660	COG2814	Major facilitator Superfamily
I6G56_RS15675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G56_RS15675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G56_RS15700	COG0436	Aminotransferase
I6G56_RS15735	COG0762	integral membrane protein
I6G56_RS15825	COG1309	transcriptional regulator
I6G56_RS15835	COG3842	ATPase activity
I6G56_RS15840	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G56_RS15845	COG1177	transmembrane transport
I6G56_RS15860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G56_RS15895	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G56_RS15905	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
I6G56_RS15915	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G56_RS15925	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6G56_RS15990	COG0859	PFAM glycosyl transferase family 9
I6G56_RS16015	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G56_RS16020	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G56_RS16030	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G56_RS16050	COG1215	transferase activity, transferring glycosyl groups
I6G56_RS16055	COG0110	maltose O-acetyltransferase activity
I6G56_RS16065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G56_RS16085	COG1216	Glycosyl transferase, family 2
I6G56_RS16085	COG0438	transferase activity, transferring glycosyl groups
I6G56_RS16110	COG1088	dTDP-glucose 4,6-dehydratase activity
I6G56_RS16135	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
I6G56_RS16155	COG1773	rubredoxin
I6G56_RS16170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6G56_RS16180	COG1733	regulation of RNA biosynthetic process
I6G56_RS16185	COG0604	alcohol dehydrogenase
I6G56_RS16235	COG1280	lysine exporter protein (LysE YggA)
I6G56_RS16250	COG0730	response to heat
I6G56_RS16310	COG0697	spore germination
I6G56_RS16320	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6G56_RS16325	COG0583	DNA-binding transcription factor activity
I6G56_RS16330	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G56_RS16335	COG0778	Nitroreductase
I6G56_RS16340	COG2814	Major facilitator Superfamily
I6G56_RS16395	COG1960	acyl-CoA dehydrogenase activity
I6G56_RS16400	COG0450	alkyl hydroperoxide reductase
I6G56_RS16455	COG4221	oxidoreductase activity
I6G56_RS16460	COG0824	Thioesterase
I6G56_RS16515	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G56_RS16520	COG0517	IMP dehydrogenase activity
I6G56_RS16520	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6G56_RS16525	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6G56_RS16530	COG2877	3-deoxy-8-phosphooctulonate synthase activity
I6G56_RS16545	COG1045	serine acetyltransferase
I6G56_RS16550	COG3562	capsule polysaccharide
I6G56_RS16560	COG3206	protein involved in exopolysaccharide biosynthesis
I6G56_RS16560	COG0489	protein tyrosine kinase activity
I6G56_RS16565	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G56_RS16570	COG1596	polysaccharide export
I6G56_RS16615	COG0156	8-amino-7-oxononanoate synthase activity
I6G56_RS16620	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
I6G56_RS16625	COG3321	synthase
I6G56_RS16625	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS16625	COG0604	alcohol dehydrogenase
I6G56_RS16630	COG1368	sulfuric ester hydrolase activity
I6G56_RS16635	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS16670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G56_RS16675	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6G56_RS16725	COG0586	Pfam SNARE associated Golgi protein
I6G56_RS16730	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
I6G56_RS16745	COG3344	reverse transcriptase
I6G56_RS16755	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6G56_RS16765	COG0617	tRNA 3'-terminal CCA addition
I6G56_RS16770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6G56_RS16775	COG1428	Deoxynucleoside kinase
I6G56_RS16785	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6G56_RS16785	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G56_RS16830	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6G56_RS16835	COG0497	DNA recombination
I6G56_RS16840	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6G56_RS16845	COG3164	Protein of unknown function
I6G56_RS16850	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G56_RS16855	COG0312	modulator of DNA gyrase
I6G56_RS16865	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G56_RS16870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G56_RS16870	COG1017	nitric oxide dioxygenase activity
I6G56_RS16875	COG2096	Adenosyltransferase
I6G56_RS16880	COG0277	FAD linked oxidase domain protein
I6G56_RS16885	COG0277	FAD linked oxidase domain protein
I6G56_RS16890	COG0277	FAD linked oxidase domain protein
I6G56_RS16895	COG0247	lactate metabolic process
I6G56_RS16910	COG3639	organic phosphonate transmembrane transporter activity
I6G56_RS16915	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6G56_RS16920	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6G56_RS16925	COG3454	Phosphonate metabolism
I6G56_RS16930	COG4778	phosphonate C-P lyase system protein PhnL
I6G56_RS16935	COG4107	phosphonate C-P lyase system protein PhnK
I6G56_RS16940	COG3627	carbon phosphorus lyase activity
I6G56_RS16945	COG3626	phosphonate metabolism
I6G56_RS16955	COG3624	Phosphonate C-P lyase system protein PhnG
I6G56_RS16960	COG2188	Transcriptional regulator
I6G56_RS16965	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6G56_RS16970	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
I6G56_RS16985	COG0783	Belongs to the Dps family
I6G56_RS17005	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6G56_RS17015	COG0343	queuine tRNA-ribosyltransferase activity
I6G56_RS17020	COG1862	Preprotein translocase
I6G56_RS17025	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G56_RS17030	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G56_RS17040	COG2353	YceI-like domain
I6G56_RS17060	COG2995	paraquat-inducible protein a
I6G56_RS17065	COG3008	intermembrane lipid transfer
I6G56_RS17065	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G56_RS17125	COG0069	glutamate synthase activity
I6G56_RS17130	COG0625	glutathione transferase activity
I6G56_RS17135	COG0006	proline dipeptidase activity
I6G56_RS17140	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G56_RS17145	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G56_RS17150	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
I6G56_RS17185	COG0588	phosphoglycerate mutase activity
I6G56_RS17195	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
I6G56_RS17205	COG0625	glutathione transferase activity
I6G56_RS17210	COG0625	glutathione transferase activity
I6G56_RS17215	COG1917	Cupin 2, conserved barrel domain protein
I6G56_RS17215	COG4977	sequence-specific DNA binding
I6G56_RS17250	COG0418	dihydroorotase activity
I6G56_RS17255	COG0121	glutamine amidotransferase
I6G56_RS17260	COG1126	abc transporter atp-binding protein
I6G56_RS17265	COG0765	amino acid transport
I6G56_RS17270	COG0765	amino acid transport
I6G56_RS17280	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6G56_RS17285	COG0583	DNA-binding transcription factor activity
I6G56_RS17290	COG2223	nitrite transmembrane transporter activity
I6G56_RS17315	COG0800	Aldolase
I6G56_RS17335	COG1981	membrane
I6G56_RS17345	COG1466	dna polymerase III delta subunit
I6G56_RS17375	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G56_RS17380	COG0735	belongs to the Fur family
I6G56_RS17385	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
I6G56_RS17390	COG4266	Belongs to the allantoicase family
I6G56_RS17395	COG1301	dicarboxylic acid transport
I6G56_RS17405	COG0583	DNA-binding transcription factor activity
I6G56_RS17420	COG2814	Major facilitator Superfamily
I6G56_RS17425	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G56_RS17430	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6G56_RS17435	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
I6G56_RS17445	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G56_RS17470	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6G56_RS17475	COG1546	Belongs to the CinA family
I6G56_RS17475	COG1058	Belongs to the CinA family
I6G56_RS17480	COG0284	orotidine-5'-phosphate decarboxylase activity
I6G56_RS17490	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS17495	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G56_RS17510	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS17520	COG3734	2-keto-3-deoxy-galactonokinase
I6G56_RS17525	COG1414	Transcriptional regulator
I6G56_RS17545	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6G56_RS17550	COG0557	exoribonuclease II activity
I6G56_RS17555	COG3150	esterase
I6G56_RS17560	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G56_RS17570	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G56_RS17575	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6G56_RS17580	COG0511	ligase activity, forming carbon-carbon bonds
I6G56_RS17585	COG0439	Biotin carboxylase
I6G56_RS17600	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6G56_RS17605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G56_RS17650	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G56_RS17655	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6G56_RS17660	COG2095	MarC family integral membrane protein
I6G56_RS17690	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6G56_RS17700	COG0142	geranyltranstransferase activity
I6G56_RS17715	COG0582	viral genome integration into host DNA
I6G56_RS17845	COG4536	flavin adenine dinucleotide binding
I6G56_RS17850	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G56_RS17860	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6G56_RS17875	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
I6G56_RS17880	COG0494	nUDIX hydrolase
I6G56_RS17915	COG0678	peroxiredoxin activity
I6G56_RS17930	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6G56_RS17965	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G56_RS17970	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G56_RS17980	COG3116	cell division
I6G56_RS18000	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS18005	COG0318	PFAM AMP-dependent synthetase and ligase
I6G56_RS18010	COG0243	molybdopterin cofactor binding
I6G56_RS18040	COG1024	Enoyl-CoA hydratase
I6G56_RS18050	COG0183	Belongs to the thiolase family
I6G56_RS18055	COG1024	Enoyl-CoA hydratase
I6G56_RS18060	COG2050	protein possibly involved in aromatic compounds catabolism
I6G56_RS18070	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6G56_RS18075	COG2967	ApaG domain
I6G56_RS18080	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G56_RS18085	COG0546	phosphoglycolate phosphatase activity
I6G56_RS18095	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G56_RS18115	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6G56_RS18130	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G56_RS18135	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G56_RS18145	COG0012	GTP binding
I6G56_RS18160	COG1111	helicase
I6G56_RS18160	COG1205	dead DEAH box helicase
I6G56_RS18165	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6G56_RS18170	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
I6G56_RS18180	COG2801	Transposase and inactivated derivatives
I6G56_RS18195	COG4372	Transposase
I6G56_RS18200	COG3344	reverse transcriptase
I6G56_RS18205	COG3436	PFAM IS66 Orf2 family protein
I6G56_RS18255	COG0488	(ABC) transporter
I6G56_RS18265	COG1335	isochorismatase
I6G56_RS18270	COG0006	proline dipeptidase activity
I6G56_RS18290	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G56_RS18295	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6G56_RS18305	COG3384	dioxygenase
I6G56_RS18310	COG0531	amino acid
I6G56_RS18315	COG1278	Cold shock
I6G56_RS18320	COG0443	Heat shock 70 kDa protein
I6G56_RS18365	COG0308	aminopeptidase N
I6G56_RS18510	COG3755	Protein conserved in bacteria
I6G56_RS18545	COG2969	positive regulation of protein catabolic process
I6G56_RS18550	COG0625	glutathione transferase activity
I6G56_RS18555	COG2857	Cytochrome c1
I6G56_RS18560	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
I6G56_RS18565	COG0723	plastoquinol--plastocyanin reductase activity
I6G56_RS18570	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G56_RS18575	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G56_RS18580	COG0805	protein transport
I6G56_RS18630	COG2095	MarC family integral membrane protein
I6G56_RS18640	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G56_RS18665	COG0842	Transport permease protein
I6G56_RS18670	COG1131	(ABC) transporter
I6G56_RS18690	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G56_RS18695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6G56_RS18700	COG1127	ABC transporter
I6G56_RS18725	COG4178	(ABC) transporter
I6G56_RS18735	COG2814	Major facilitator Superfamily
I6G56_RS18750	COG1115	amino acid carrier protein
I6G56_RS18760	COG0067	glutamate synthase
I6G56_RS18760	COG0070	glutamate synthase
I6G56_RS18760	COG0069	glutamate synthase activity
I6G56_RS18775	COG0584	glycerophosphoryl diester phosphodiesterase
I6G56_RS18785	COG0395	ABC-type sugar transport system, permease component
I6G56_RS18855	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6G56_RS18860	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6G56_RS18865	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G56_RS18870	COG1333	cytochrome c biogenesis protein
I6G56_RS18890	COG4232	protein-disulfide reductase activity
I6G56_RS18935	COG0201	protein transport
I6G56_RS19065	COG0514	ATP-dependent DNA helicase (RecQ)
I6G56_RS19085	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6G56_RS19105	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G56_RS19165	COG3396	Phenylacetate-CoA oxygenase
I6G56_RS19170	COG3460	Phenylacetate-CoA oxygenase
I6G56_RS19175	COG3396	Phenylacetate-CoA oxygenase
I6G56_RS19180	COG2151	metal-sulfur cluster biosynthetic enzyme
I6G56_RS19185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G56_RS19205	COG1522	sequence-specific DNA binding
I6G56_RS19225	COG0281	malic enzyme
I6G56_RS19225	COG0280	phosphate acetyltransferase
I6G56_RS19230	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6G56_RS19235	COG1881	PFAM PEBP family protein
I6G56_RS19245	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6G56_RS19260	COG3047	cAMP biosynthetic process
I6G56_RS19265	COG0583	DNA-binding transcription factor activity
I6G56_RS19270	COG2814	Major facilitator Superfamily
I6G56_RS19275	COG1280	lysine exporter protein (LysE YggA)
I6G56_RS19280	COG2084	Dehydrogenase
I6G56_RS19330	COG1113	amino acid transport
I6G56_RS19350	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
I6G56_RS19370	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G56_RS19380	COG1522	sequence-specific DNA binding
I6G56_RS19385	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6G56_RS19415	COG2070	2-Nitropropane dioxygenase
I6G56_RS19430	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6G56_RS19435	COG1950	PFAM Membrane protein of
I6G56_RS19450	COG2894	cell division
I6G56_RS19460	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6G56_RS19465	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6G56_RS19480	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6G56_RS19485	COG0745	RESPONSE REGULATOR receiver
I6G56_RS19500	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6G56_RS19505	COG0840	transmembrane signaling receptor activity
I6G56_RS19545	COG0438	transferase activity, transferring glycosyl groups
I6G56_RS19550	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6G56_RS19555	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G56_RS19570	COG0519	Catalyzes the synthesis of GMP from XMP
I6G56_RS19640	COG0596	Alpha beta hydrolase
I6G56_RS19645	COG0840	transmembrane signaling receptor activity
I6G56_RS19655	COG3397	chitin binding
I6G56_RS19730	COG0582	viral genome integration into host DNA
I6G56_RS19800	COG3245	cytochrome
I6G56_RS19805	COG0210	DNA helicase
I6G56_RS19820	COG0673	inositol 2-dehydrogenase activity
I6G56_RS19835	COG0509	glycine decarboxylation via glycine cleavage system
I6G56_RS19850	COG1760	l-serine dehydratase
I6G56_RS19855	COG0028	Belongs to the TPP enzyme family
I6G56_RS19865	COG2207	Transcriptional regulator
I6G56_RS19870	COG1012	belongs to the aldehyde dehydrogenase family
I6G56_RS19875	COG0477	Major facilitator Superfamily
I6G56_RS19880	COG0583	DNA-binding transcription factor activity
I6G56_RS19885	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G56_RS19885	COG2169	Transcriptional regulator
I6G56_RS19890	COG4302	ethanolamine ammonia-lyase activity
I6G56_RS19895	COG4303	Ethanolamine ammonia lyase large subunit
I6G56_RS19900	COG0531	amino acid
I6G56_RS19920	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G56_RS19925	COG0668	transmembrane transport
I6G56_RS19945	COG0789	Transcriptional regulator
I6G56_RS19955	COG0277	FAD linked oxidase domain protein
I6G56_RS19965	COG0436	Aminotransferase
I6G56_RS19975	COG1960	acyl-CoA dehydrogenase activity
I6G56_RS19985	COG0683	leucine binding
I6G56_RS19990	COG0506	proline dehydrogenase activity
I6G56_RS19990	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6G56_RS19990	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6G56_RS20000	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G56_RS20015	COG1832	CoA-binding protein
I6G56_RS20025	COG0318	PFAM AMP-dependent synthetase and ligase
I6G56_RS20040	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6G56_RS20070	COG1215	transferase activity, transferring glycosyl groups
I6G56_RS20075	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6G56_RS20080	COG0457	Tetratricopeptide repeat
I6G56_RS20100	COG1215	transferase activity, transferring glycosyl groups
I6G56_RS20105	COG2194	sulfuric ester hydrolase activity
I6G56_RS20115	COG2175	clavaminate synthase activity
I6G56_RS20120	COG4521	taurine ABC transporter
I6G56_RS20130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G56_RS20140	COG3916	Acyl-homoserine-lactone synthase
I6G56_RS20160	COG0306	phosphate transporter
I6G56_RS20165	COG1522	sequence-specific DNA binding
I6G56_RS20170	COG1280	lysine exporter protein (LysE YggA)
I6G56_RS20255	COG2801	Transposase and inactivated derivatives
I6G56_RS20265	COG0582	viral genome integration into host DNA
I6G56_RS20270	COG0477	Major facilitator Superfamily
I6G56_RS20380	COG4790	Type iii secretion
I6G56_RS20415	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6G56_RS20430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G56_RS20575	COG5295	Hep Hag repeat protein
I6G56_RS20585	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G56_RS20610	COG5564	TIM-barrel signal transduction protein
I6G56_RS20615	COG5441	Belongs to the UPF0261 family
I6G56_RS20640	COG1349	DNA-binding transcription factor activity
I6G56_RS20655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G56_RS20665	COG0583	DNA-binding transcription factor activity
I6G56_RS20675	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G56_RS20680	COG1012	belongs to the aldehyde dehydrogenase family
I6G56_RS20700	COG1609	Transcriptional regulator
I6G56_RS20705	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G56_RS20705	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G56_RS20715	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G56_RS20715	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G56_RS20725	COG0625	glutathione transferase activity
I6G56_RS20730	COG2271	Major facilitator Superfamily
I6G56_RS20770	COG1960	acyl-CoA dehydrogenase activity
I6G56_RS20775	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6G56_RS20810	COG5295	Hep Hag repeat protein
I6G56_RS20855	COG4175	Glycine betaine
I6G56_RS20890	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G56_RS20895	COG3622	Belongs to the hyi family
I6G56_RS20900	COG2271	Major facilitator Superfamily
I6G56_RS20905	COG0235	Class ii aldolase
I6G56_RS20910	COG3395	kinase activity
I6G56_RS20915	COG2084	Dehydrogenase
I6G56_RS20920	COG2186	Transcriptional regulator
I6G56_RS21010	COG1222	aaa ATPase
I6G56_RS21075	COG1760	l-serine dehydratase
I6G56_RS21090	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6G56_RS21090	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G56_RS21115	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G56_RS21125	COG4251	negative regulation of phosphorylation
I6G56_RS21130	COG0784	Response regulator, receiver
I6G56_RS21140	COG0477	Major facilitator Superfamily
I6G56_RS21175	COG2814	Major facilitator Superfamily
I6G56_RS21190	COG1566	PFAM secretion protein HlyD family protein
I6G56_RS21195	COG1505	serine-type exopeptidase activity
I6G56_RS21205	COG1045	serine acetyltransferase
I6G56_RS21215	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G56_RS21220	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G56_RS21235	COG0640	Transcriptional regulator
I6G56_RS21240	COG2391	methyltransferase activity
I6G56_RS21275	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
I6G56_RS21280	COG1858	cytochrome C peroxidase
I6G56_RS21295	COG2814	Major facilitator Superfamily
I6G56_RS21300	COG2188	Transcriptional regulator
I6G56_RS21360	COG0277	FAD linked oxidase domain protein
I6G56_RS21365	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I6G56_RS21375	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6G56_RS21385	COG4608	Belongs to the ABC transporter superfamily
I6G56_RS21390	COG0444	Belongs to the ABC transporter superfamily
I6G56_RS21405	COG0747	negative chemotaxis
I6G56_RS21450	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G56_RS21460	COG1446	asparaginase
I6G56_RS21465	COG4172	Belongs to the ABC transporter superfamily
I6G56_RS21470	COG0747	negative chemotaxis
I6G56_RS21480	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G56_RS21505	COG3485	protocatechuate 3,4-dioxygenase
I6G56_RS21510	COG3485	protocatechuate 3,4-dioxygenase
I6G56_RS21515	COG0583	DNA-binding transcription factor activity
I6G56_RS21530	COG3706	GGDEF domain
I6G56_RS21530	COG4251	negative regulation of phosphorylation
I6G56_RS21530	COG2203	Gaf domain
I6G56_RS21530	COG5001	Diguanylate cyclase
I6G56_RS21535	COG4122	O-methyltransferase activity
I6G56_RS21540	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G56_RS21555	COG2198	Histidine kinase
I6G56_RS21555	COG2205	protein histidine kinase activity
I6G56_RS21555	COG0784	Response regulator, receiver
I6G56_RS21565	COG5002	protein histidine kinase activity
I6G56_RS21570	COG5002	protein histidine kinase activity
I6G56_RS21570	COG3447	MASE1 domain protein
I6G56_RS21570	COG5001	Diguanylate cyclase
I6G56_RS21580	COG0531	amino acid
I6G56_RS21590	COG1201	RNA secondary structure unwinding
I6G56_RS21650	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G56_RS21665	COG1739	Uncharacterized protein family UPF0029
I6G56_RS21735	COG1794	racemase activity, acting on amino acids and derivatives
I6G56_RS21740	COG0583	DNA-binding transcription factor activity
I6G56_RS21745	COG0477	Major facilitator Superfamily
I6G56_RS21765	COG1116	anion transmembrane transporter activity
I6G56_RS21765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G56_RS21770	COG3707	response regulator
I6G56_RS21785	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G56_RS21790	COG2146	nitrite reductase [NAD(P)H] activity
I6G56_RS21795	COG0243	molybdopterin cofactor binding
I6G56_RS21805	COG1070	Carbohydrate kinase
I6G56_RS21815	COG3842	ATPase activity
I6G56_RS21820	COG1063	alcohol dehydrogenase
I6G56_RS21825	COG0395	ABC-type sugar transport system, permease component
I6G56_RS21895	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G56_RS21895	COG4651	solute:proton antiporter activity
I6G56_RS21900	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS21915	COG0840	transmembrane signaling receptor activity
I6G56_RS21925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G56_RS21935	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6G56_RS21950	COG1132	(ABC) transporter
I6G56_RS21955	COG1132	(ABC) transporter
I6G56_RS21960	COG4771	TonB-dependent receptor
I6G56_RS21980	COG2072	flavoprotein involved in K transport
I6G56_RS21985	COG0583	DNA-binding transcription factor activity
I6G56_RS22030	COG1335	isochorismatase
I6G56_RS22050	COG0540	Belongs to the ATCase OTCase family
I6G56_RS22065	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G56_RS22075	COG1414	Transcriptional regulator
I6G56_RS22080	COG0477	Major facilitator Superfamily
I6G56_RS22100	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G56_RS22115	COG3851	Histidine kinase
I6G56_RS22125	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6G56_RS22130	COG1140	nitrate reductase beta subunit
I6G56_RS22135	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6G56_RS22140	COG2181	nitrate reductase activity
I6G56_RS22145	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G56_RS22170	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G56_RS22185	COG0651	ATP synthesis coupled electron transport
I6G56_RS22190	COG0650	Formate hydrogenlyase subunit 4
I6G56_RS22200	COG0651	ATP synthesis coupled electron transport
I6G56_RS22205	COG0649	NAD binding
I6G56_RS22210	COG3260	NADH ubiquinone oxidoreductase 20
I6G56_RS22235	COG1695	Transcriptional regulator
I6G56_RS22240	COG1902	pentaerythritol trinitrate reductase activity
I6G56_RS22240	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G56_RS22275	COG2345	Transcriptional regulator
I6G56_RS22280	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G56_RS22280	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G56_RS22285	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6G56_RS22300	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6G56_RS22315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G56_RS22320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G56_RS22400	COG3547	Transposase (IS116 IS110 IS902 family)
I6G56_RS22415	COG2264	protein methyltransferase activity
I6G56_RS22425	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6G56_RS22445	COG0443	Heat shock 70 kDa protein
I6G56_RS22470	COG2801	Transposase and inactivated derivatives
I6G56_RS22645	COG4695	Portal protein
I6G56_RS22650	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G56_RS22655	COG3657	addiction module killer protein
I6G56_RS22680	COG1192	Involved in chromosome partitioning
I6G56_RS22710	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6G56_RS22760	COG0681	Belongs to the peptidase S26 family
I6G56_RS22835	COG1129	ABC transporter
I6G56_RS22840	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G56_RS22845	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G56_RS22860	COG3712	iron ion homeostasis
I6G56_RS22865	COG1595	DNA-templated transcription, initiation
I6G56_RS22875	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6G56_RS22885	COG2353	YceI-like domain
I6G56_RS22910	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G56_RS22925	COG3220	belongs to the UPF0276 family
I6G56_RS22965	COG0387	Pfam Sodium calcium exchanger
I6G56_RS22970	COG0583	DNA-binding transcription factor activity
I6G56_RS22990	COG0500	methyltransferase
I6G56_RS23000	COG3275	phosphorelay sensor kinase activity
I6G56_RS23040	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6G56_RS23050	COG4160	amino acid transport
I6G56_RS23065	COG2259	Doxx family
I6G56_RS23095	COG1404	Belongs to the peptidase S8 family
I6G56_RS23110	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G56_RS23115	COG0243	molybdopterin cofactor binding
I6G56_RS23120	COG3781	membrane
I6G56_RS23125	COG4682	membrane
I6G56_RS23130	COG1914	H( )-stimulated, divalent metal cation uptake system
I6G56_RS23135	COG2140	Oxalate decarboxylase
I6G56_RS23140	COG0747	negative chemotaxis
I6G56_RS23150	COG1012	belongs to the aldehyde dehydrogenase family
I6G56_RS23170	COG2837	iron assimilation
I6G56_RS23185	COG3842	ATPase activity
I6G56_RS23195	COG3209	COG3209 Rhs family protein
I6G56_RS23230	COG0601	transmembrane transport
I6G56_RS23235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G56_RS23250	COG0583	DNA-binding transcription factor activity
I6G56_RS23275	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS23290	COG2423	ornithine cyclodeaminase activity
I6G56_RS23305	COG0596	Alpha beta hydrolase
I6G56_RS23310	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G56_RS23315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G56_RS23330	COG0840	transmembrane signaling receptor activity
I6G56_RS23350	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G56_RS23415	COG1522	sequence-specific DNA binding
I6G56_RS23440	COG0477	Major facilitator Superfamily
I6G56_RS23455	COG1012	belongs to the aldehyde dehydrogenase family
I6G56_RS23465	COG0028	Belongs to the TPP enzyme family
I6G56_RS23470	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS23475	COG1414	Transcriptional regulator
I6G56_RS23490	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS23505	COG2146	nitrite reductase [NAD(P)H] activity
I6G56_RS23510	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS23515	COG1414	Transcriptional regulator
I6G56_RS23530	COG1408	metallophosphoesterase
I6G56_RS23535	COG1285	pathogenesis
I6G56_RS23540	COG2197	response regulator
I6G56_RS23560	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I6G56_RS23565	COG0517	IMP dehydrogenase activity
I6G56_RS23565	COG0516	GMP reductase activity
I6G56_RS23575	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G56_RS23580	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS23595	COG1902	pentaerythritol trinitrate reductase activity
I6G56_RS23610	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS23625	COG0531	amino acid
I6G56_RS23630	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G56_RS23635	COG1012	belongs to the aldehyde dehydrogenase family
I6G56_RS23665	COG0604	alcohol dehydrogenase
I6G56_RS23675	COG0583	DNA-binding transcription factor activity
I6G56_RS23710	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G56_RS23745	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6G56_RS23785	COG0589	response to stress
I6G56_RS23830	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G56_RS23840	COG3291	Pkd domain containing protein
I6G56_RS23860	COG2175	clavaminate synthase activity
I6G56_RS23880	COG0495	leucyl-tRNA aminoacylation
I6G56_RS23900	COG2373	Large extracellular alpha-helical protein
I6G56_RS23905	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G56_RS23935	COG1131	(ABC) transporter
I6G56_RS23940	COG0842	Transport permease protein
I6G56_RS23970	COG1448	Aminotransferase
I6G56_RS23985	COG1272	protein, Hemolysin III
I6G56_RS24005	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS24015	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS24025	COG2721	sulfolactate sulfo-lyase activity
I6G56_RS24035	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G56_RS24040	COG1129	ABC transporter
I6G56_RS24060	COG5295	Hep Hag repeat protein
I6G56_RS24080	COG4774	siderophore transport
I6G56_RS24165	COG3511	phospholipase C
I6G56_RS24170	COG1858	cytochrome C peroxidase
I6G56_RS24175	COG3547	Transposase (IS116 IS110 IS902 family)
I6G56_RS24185	COG0038	chloride channel
I6G56_RS24210	COG0402	S-adenosylhomocysteine deaminase activity
I6G56_RS24215	COG2508	Transcriptional regulator
I6G56_RS24220	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6G56_RS24230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS24245	COG0583	DNA-binding transcription factor activity
I6G56_RS24315	COG0825	malonyl-CoA metabolic process
I6G56_RS24360	COG0318	PFAM AMP-dependent synthetase and ligase
I6G56_RS24375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G56_RS24380	COG1538	Outer membrane efflux protein
I6G56_RS24390	COG0642	Histidine kinase
I6G56_RS24405	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS24425	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6G56_RS24430	COG1902	pentaerythritol trinitrate reductase activity
I6G56_RS24440	COG1309	transcriptional regulator
I6G56_RS24455	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
I6G56_RS24460	COG1262	PFAM Formylglycine-generating sulfatase enzyme
I6G56_RS24475	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G56_RS24480	COG1024	Enoyl-CoA hydratase
I6G56_RS24495	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS24510	COG0583	DNA-binding transcription factor activity
I6G56_RS24525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G56_RS24545	COG1116	anion transmembrane transporter activity
I6G56_RS24550	COG2010	Cytochrome c
I6G56_RS24565	COG0633	Ferredoxin
I6G56_RS24565	COG3217	Mosc domain protein beta barrel domain protein
I6G56_RS24570	COG0642	Histidine kinase
I6G56_RS24590	COG3842	ATPase activity
I6G56_RS24595	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS24605	COG3971	2-oxopent-4-enoate hydratase activity
I6G56_RS24615	COG3384	dioxygenase
I6G56_RS24620	COG1012	belongs to the aldehyde dehydrogenase family
I6G56_RS24635	COG1846	Transcriptional regulator
I6G56_RS24650	COG0745	RESPONSE REGULATOR receiver
I6G56_RS24655	COG2205	protein histidine kinase activity
I6G56_RS24685	COG2207	Transcriptional regulator
I6G56_RS24700	COG0745	RESPONSE REGULATOR receiver
I6G56_RS24720	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6G56_RS24730	COG0477	Major facilitator Superfamily
I6G56_RS24745	COG3214	Protein conserved in bacteria
I6G56_RS24810	COG0642	Histidine kinase
I6G56_RS24890	COG2205	protein histidine kinase activity
I6G56_RS24895	COG0745	RESPONSE REGULATOR receiver
I6G56_RS24905	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G56_RS24940	COG2066	Belongs to the glutaminase family
I6G56_RS24970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G56_RS24980	COG1538	Outer membrane efflux protein
I6G56_RS24985	COG1024	Enoyl-CoA hydratase
I6G56_RS24990	COG1024	Enoyl-CoA hydratase
I6G56_RS25005	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6G56_RS25010	COG1960	acyl-CoA dehydrogenase activity
I6G56_RS25025	COG0330	HflC and HflK could
I6G56_RS25070	COG2252	PERMEase
I6G56_RS25085	COG3284	Transcriptional regulator
I6G56_RS25160	COG0657	acetylesterase activity
I6G56_RS25165	COG0824	Thioesterase
I6G56_RS25165	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G56_RS25170	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G56_RS25175	COG3246	L-lysine catabolic process to acetate
I6G56_RS25220	COG3119	arylsulfatase activity
I6G56_RS25235	COG2113	Glycine betaine
I6G56_RS25255	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6G56_RS25260	COG0247	lactate metabolic process
I6G56_RS25260	COG2181	nitrate reductase activity
I6G56_RS25265	COG1902	pentaerythritol trinitrate reductase activity
I6G56_RS25265	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G56_RS25315	COG1621	beta-fructofuranosidase activity
I6G56_RS25320	COG1566	PFAM secretion protein HlyD family protein
I6G56_RS25335	COG2814	Major facilitator Superfamily
I6G56_RS25485	COG0028	Belongs to the TPP enzyme family
I6G56_RS25485	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
I6G56_RS25490	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I6G56_RS25495	COG1289	transmembrane transporter activity
I6G56_RS25515	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G56_RS25520	COG1305	Transglutaminase-like
I6G56_RS25545	COG2308	Evidence 4 Homologs of previously reported genes of
I6G56_RS25555	COG0778	Nitroreductase
I6G56_RS25600	COG3436	PFAM IS66 Orf2 family protein
I6G56_RS25685	COG2205	protein histidine kinase activity
I6G56_RS25685	COG0784	Response regulator, receiver
I6G56_RS25690	COG2197	response regulator
I6G56_RS25715	COG3436	PFAM IS66 Orf2 family protein
I6G56_RS25745	COG4615	Cyclic peptide transporter
I6G56_RS25775	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G56_RS25815	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G56_RS25820	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G56_RS25840	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G56_RS25855	COG1120	ATPase activity
I6G56_RS25865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G56_RS25875	COG4774	siderophore transport
I6G56_RS25885	COG1595	DNA-templated transcription, initiation
I6G56_RS25910	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6G56_RS25920	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G56_RS25925	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G56_RS25935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G56_RS25950	COG2175	clavaminate synthase activity
I6G56_RS25960	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G56_RS25985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G56_RS25995	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS26005	COG1012	belongs to the aldehyde dehydrogenase family
I6G56_RS26010	COG1177	transmembrane transport
I6G56_RS26015	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G56_RS26025	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G56_RS26030	COG3842	ATPase activity
I6G56_RS26035	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6G56_RS26040	COG0583	DNA-binding transcription factor activity
I6G56_RS26125	COG3344	reverse transcriptase
I6G56_RS26130	COG3436	PFAM IS66 Orf2 family protein
I6G56_RS26175	COG0300	oxidoreductase activity
I6G56_RS26175	COG3321	synthase
I6G56_RS26175	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS26175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G56_RS26175	COG0318	PFAM AMP-dependent synthetase and ligase
I6G56_RS26180	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G56_RS26215	COG1309	transcriptional regulator
I6G56_RS26220	COG0477	Major facilitator Superfamily
I6G56_RS26230	COG1120	ATPase activity
I6G56_RS26235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G56_RS26240	COG4774	siderophore transport
I6G56_RS26255	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G56_RS26295	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G56_RS26305	COG0477	Major facilitator Superfamily
I6G56_RS26325	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G56_RS26345	COG2081	HI0933 family
I6G56_RS26365	COG0142	geranyltranstransferase activity
I6G56_RS26385	COG0412	Dienelactone hydrolase
I6G56_RS26395	COG1252	NADH dehydrogenase
I6G56_RS26405	COG1611	Belongs to the LOG family
I6G56_RS26580	COG5410	chromosome segregation
I6G56_RS26760	COG0419	ATPase involved in DNA repair
I6G56_RS26855	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G56_RS26875	COG1846	Transcriptional regulator
I6G56_RS26880	COG1764	response to oxidative stress
I6G56_RS26905	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6G56_RS26910	COG4149	molybdate abc transporter
I6G56_RS26915	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6G56_RS26935	COG0583	DNA-binding transcription factor activity
I6G56_RS26950	COG1253	flavin adenine dinucleotide binding
I6G56_RS26955	COG0352	thiamine-phosphate diphosphorylase activity
I6G56_RS26960	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
I6G56_RS26980	COG1280	lysine exporter protein (LysE YggA)
I6G56_RS27010	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
I6G56_RS27030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G56_RS27050	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6G56_RS27055	COG5654	RES domain protein
I6G56_RS27060	COG5642	Protein of unknown function (DUF2384)
I6G56_RS27080	COG0438	transferase activity, transferring glycosyl groups
I6G56_RS27085	COG0438	transferase activity, transferring glycosyl groups
I6G56_RS27105	COG3206	protein involved in exopolysaccharide biosynthesis
I6G56_RS27105	COG0489	protein tyrosine kinase activity
I6G56_RS27125	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G56_RS27150	COG0247	lactate metabolic process
I6G56_RS27155	COG1592	Rubrerythrin
I6G56_RS27160	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G56_RS27165	COG4941	Belongs to the sigma-70 factor family
I6G56_RS27175	COG3795	YCII-related domain
I6G56_RS27180	COG3795	YCII-related domain
I6G56_RS27200	COG0628	permease
I6G56_RS27230	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS27250	COG0583	DNA-binding transcription factor activity
I6G56_RS27260	COG2837	iron assimilation
I6G56_RS27265	COG5265	(ABC) transporter
I6G56_RS27275	COG4977	sequence-specific DNA binding
I6G56_RS27295	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
I6G56_RS27315	COG0038	chloride channel
I6G56_RS27350	COG0840	transmembrane signaling receptor activity
I6G56_RS27355	COG0642	Histidine kinase
I6G56_RS27365	COG1012	belongs to the aldehyde dehydrogenase family
I6G56_RS27375	COG0025	NhaP-type Na H and K H
I6G56_RS27380	COG2733	membrane
I6G56_RS27390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G56_RS27405	COG2146	nitrite reductase [NAD(P)H] activity
I6G56_RS27410	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6G56_RS27415	COG4638	Rieske (2fe-2S)
I6G56_RS27455	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6G56_RS27475	COG1902	pentaerythritol trinitrate reductase activity
I6G56_RS27475	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G56_RS27505	COG0583	DNA-binding transcription factor activity
I6G56_RS27510	COG4638	Rieske (2fe-2S)
I6G56_RS27515	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
I6G56_RS27520	COG0543	2 iron, 2 sulfur cluster binding
I6G56_RS27520	COG0633	Ferredoxin
I6G56_RS27525	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS27540	COG1335	isochorismatase
I6G56_RS27555	COG0833	amino acid
I6G56_RS27565	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
I6G56_RS27570	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS27575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G56_RS27645	COG1136	(ABC) transporter
I6G56_RS27660	COG0589	response to stress
I6G56_RS27675	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G56_RS27680	COG1129	ABC transporter
I6G56_RS27680	COG0842	Transport permease protein
I6G56_RS27685	COG0842	Transport permease protein
I6G56_RS27700	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6G56_RS27710	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6G56_RS27710	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6G56_RS27720	COG0356	it plays a direct role in the translocation of protons across the membrane
I6G56_RS27735	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6G56_RS27755	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6G56_RS27765	COG2823	Periplasmic or secreted lipoprotein
I6G56_RS27770	COG0295	cytidine deaminase activity
I6G56_RS27790	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6G56_RS27795	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G56_RS27800	COG1017	nitric oxide dioxygenase activity
I6G56_RS27800	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G56_RS27805	COG0625	glutathione transferase activity
I6G56_RS27830	COG0596	Alpha beta hydrolase
I6G56_RS27875	COG3206	protein involved in exopolysaccharide biosynthesis
I6G56_RS27875	COG0489	protein tyrosine kinase activity
I6G56_RS27895	COG1230	cation diffusion facilitator family transporter
I6G56_RS27945	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G56_RS27950	COG0765	amino acid transport
I6G56_RS27955	COG0765	amino acid transport
I6G56_RS27960	COG4598	ABC transporter
I6G56_RS27985	COG1573	uracil-dna glycosylase
I6G56_RS27995	COG1404	Belongs to the peptidase S8 family
I6G56_RS28065	COG0513	Belongs to the DEAD box helicase family
I6G56_RS28105	COG1215	transferase activity, transferring glycosyl groups
I6G56_RS28120	COG0583	DNA-binding transcription factor activity
I6G56_RS28125	COG1253	flavin adenine dinucleotide binding
I6G56_RS28140	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6G56_RS28150	COG1960	acyl-CoA dehydrogenase activity
I6G56_RS28165	COG1720	tRNA m6t6A37 methyltransferase activity
I6G56_RS28205	COG0477	Major facilitator Superfamily
I6G56_RS28225	COG1960	acyl-CoA dehydrogenase activity
I6G56_RS28230	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS28235	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6G56_RS28240	COG1960	acyl-CoA dehydrogenase activity
I6G56_RS28255	COG3246	L-lysine catabolic process to acetate
I6G56_RS28260	COG1022	Amp-dependent synthetase and ligase
I6G56_RS28310	COG0318	PFAM AMP-dependent synthetase and ligase
I6G56_RS28340	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS28350	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
I6G56_RS28350	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6G56_RS28355	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G56_RS28360	COG0406	alpha-ribazole phosphatase activity
I6G56_RS28380	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS28390	COG3209	COG3209 Rhs family protein
I6G56_RS28510	COG0463	Glycosyl transferase, family 2
I6G56_RS28560	COG4964	Belongs to the GSP D family
I6G56_RS28615	COG2271	Major facilitator Superfamily
I6G56_RS28640	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6G56_RS28740	COG2198	Histidine kinase
I6G56_RS28740	COG2205	protein histidine kinase activity
I6G56_RS28740	COG0784	Response regulator, receiver
I6G56_RS28740	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G56_RS28755	COG2204	response regulator
I6G56_RS28770	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G56_RS28775	COG2091	lysine biosynthetic process via aminoadipic acid
I6G56_RS28785	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G56_RS28810	COG0022	dehydrogenase e1 component
I6G56_RS28845	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G56_RS28890	COG0071	Belongs to the small heat shock protein (HSP20) family
I6G56_RS28935	COG1802	Transcriptional regulator
I6G56_RS28940	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6G56_RS28950	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS28955	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G56_RS28975	COG4172	Belongs to the ABC transporter superfamily
I6G56_RS28980	COG4239	(ABC) transporter, permease
I6G56_RS28985	COG4174	ABC transporter (Permease)
I6G56_RS28995	COG4771	TonB-dependent receptor
I6G56_RS29000	COG1396	sequence-specific DNA binding
I6G56_RS29050	COG5002	protein histidine kinase activity
I6G56_RS29050	COG3447	MASE1 domain protein
I6G56_RS29050	COG5001	Diguanylate cyclase
I6G56_RS29060	COG2091	lysine biosynthetic process via aminoadipic acid
I6G56_RS29085	COG1136	(ABC) transporter
I6G56_RS29090	COG2072	flavoprotein involved in K transport
I6G56_RS29100	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS29125	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G56_RS29135	COG1126	abc transporter atp-binding protein
I6G56_RS29140	COG0765	amino acid transport
I6G56_RS29145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G56_RS29155	COG1657	PFAM Prenyltransferase squalene oxidase
I6G56_RS29160	COG1562	ergosterol biosynthetic process
I6G56_RS29195	COG1595	DNA-templated transcription, initiation
I6G56_RS29205	COG1393	Belongs to the ArsC family
I6G56_RS29210	COG1192	Involved in chromosome partitioning
I6G56_RS29240	COG1396	sequence-specific DNA binding
I6G56_RS29255	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
I6G56_RS29275	COG1309	transcriptional regulator
I6G56_RS29290	COG0473	3-isopropylmalate dehydrogenase activity
I6G56_RS29295	COG0583	DNA-binding transcription factor activity
I6G56_RS29315	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS29325	COG0671	phosphoesterase, PA-phosphatase related
I6G56_RS29385	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
I6G56_RS29400	COG0583	DNA-binding transcription factor activity
I6G56_RS29405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G56_RS29410	COG0589	response to stress
I6G56_RS29440	COG1045	serine acetyltransferase
I6G56_RS29445	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS29450	COG0302	gtp cyclohydrolase
I6G56_RS29470	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G56_RS29480	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6G56_RS29485	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G56_RS29515	COG1309	transcriptional regulator
I6G56_RS29535	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6G56_RS29540	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS29545	COG2814	Major facilitator Superfamily
I6G56_RS29560	COG0076	glutamate decarboxylase activity
I6G56_RS29605	COG0625	glutathione transferase activity
I6G56_RS29615	COG1063	alcohol dehydrogenase
I6G56_RS29640	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G56_RS29655	COG0686	Belongs to the AlaDH PNT family
I6G56_RS29675	COG3876	Protein conserved in bacteria
I6G56_RS29690	COG0432	Pfam Uncharacterised protein family UPF0047
I6G56_RS29710	COG0417	DNA replication proofreading
I6G56_RS29715	COG2271	Major facilitator Superfamily
I6G56_RS29720	COG1929	Belongs to the glycerate kinase type-1 family
I6G56_RS29725	COG0469	pyruvate kinase activity
I6G56_RS29730	COG3835	regulator
I6G56_RS29740	COG0318	PFAM AMP-dependent synthetase and ligase
I6G56_RS29740	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS29740	COG3321	synthase
I6G56_RS29740	COG0300	oxidoreductase activity
I6G56_RS29740	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G56_RS29760	COG3706	GGDEF domain
I6G56_RS29760	COG5001	Diguanylate cyclase
I6G56_RS29760	COG4251	negative regulation of phosphorylation
I6G56_RS29760	COG2203	Gaf domain
I6G56_RS29770	COG1879	ABC-type sugar transport system periplasmic component
I6G56_RS29775	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G56_RS29805	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS29840	COG0583	DNA-binding transcription factor activity
I6G56_RS29860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G56_RS29895	COG2885	chlorophyll binding
I6G56_RS30005	COG0583	DNA-binding transcription factor activity
I6G56_RS30010	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G56_RS30020	COG0583	DNA-binding transcription factor activity
I6G56_RS30025	COG0477	Major facilitator Superfamily
I6G56_RS30050	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G56_RS30055	COG1177	transmembrane transport
I6G56_RS30065	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6G56_RS30090	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6G56_RS30095	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6G56_RS30115	COG1966	Carbon starvation protein
I6G56_RS30120	COG2879	small protein
I6G56_RS30130	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6G56_RS30145	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6G56_RS30165	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G56_RS30205	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G56_RS30215	COG2271	Major facilitator Superfamily
I6G56_RS30225	COG0477	Major facilitator Superfamily
I6G56_RS30230	COG1335	isochorismatase
I6G56_RS30240	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G56_RS30245	COG2301	Belongs to the HpcH HpaI aldolase family
I6G56_RS30250	COG2079	MmgE PrpD family protein
I6G56_RS30275	COG3104	oligopeptide transport
I6G56_RS30290	COG0601	transmembrane transport
I6G56_RS30295	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G56_RS30300	COG0444	Belongs to the ABC transporter superfamily
I6G56_RS30325	COG2610	gluconate transmembrane transporter activity
I6G56_RS30345	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6G56_RS30375	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G56_RS30390	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6G56_RS30415	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G56_RS30415	COG2226	methyltransferase
I6G56_RS30415	COG3433	isochorismatase activity
I6G56_RS30435	COG4771	TonB-dependent receptor
I6G56_RS30440	COG2375	cellular response to nickel ion
I6G56_RS30440	COG1132	(ABC) transporter
I6G56_RS30515	COG0535	radical SAM domain protein
I6G56_RS30520	COG0840	transmembrane signaling receptor activity
I6G56_RS30540	COG1285	pathogenesis
I6G56_RS30595	COG0346	lactoylglutathione lyase activity
I6G56_RS30605	COG1562	ergosterol biosynthetic process
I6G56_RS30615	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G56_RS30630	COG1294	oxidase, subunit
I6G56_RS30635	COG1271	oxidase subunit
I6G56_RS30640	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6G56_RS30655	COG2860	membrane
I6G56_RS30665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G56_RS30670	COG4558	Periplasmic binding protein
I6G56_RS30675	COG3720	iron ion transport
I6G56_RS30680	COG4771	TonB-dependent receptor
I6G56_RS30700	COG3842	ATPase activity
I6G56_RS30705	COG1840	ABC-type Fe3 transport system, periplasmic component
I6G56_RS30720	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS30730	COG0698	ribose 5-phosphate isomerase
I6G56_RS30735	COG1129	ABC transporter
I6G56_RS30740	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G56_RS30745	COG1879	ABC-type sugar transport system periplasmic component
I6G56_RS30750	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS30755	COG1063	alcohol dehydrogenase
I6G56_RS30760	COG2376	Dihydroxyacetone kinase
I6G56_RS30765	COG1461	Dihydroxyacetone kinase
I6G56_RS30785	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS30790	COG1464	Belongs to the NlpA lipoprotein family
I6G56_RS30800	COG2755	lipolytic protein G-D-S-L family
I6G56_RS30800	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6G56_RS30815	COG1473	amidohydrolase
I6G56_RS30825	COG1309	transcriptional regulator
I6G56_RS30830	COG1414	Transcriptional regulator
I6G56_RS30835	COG0183	Belongs to the thiolase family
I6G56_RS30840	COG0840	transmembrane signaling receptor activity
I6G56_RS30850	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G56_RS30865	COG0709	Synthesizes selenophosphate from selenide and ATP
I6G56_RS30880	COG0583	DNA-binding transcription factor activity
I6G56_RS30885	COG0657	acetylesterase activity
I6G56_RS30890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G56_RS30905	COG1301	dicarboxylic acid transport
I6G56_RS30960	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G56_RS30965	COG2011	ABC-type metal ion transport system permease component
I6G56_RS30985	COG2186	Transcriptional regulator
I6G56_RS30990	COG0247	lactate metabolic process
I6G56_RS30995	COG1139	Iron-sulfur cluster binding protein
I6G56_RS31000	COG1556	Lactate utilization protein
I6G56_RS31005	COG1620	l-lactate permease
I6G56_RS31010	COG2259	Doxx family
I6G56_RS31025	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6G56_RS31035	COG0531	amino acid
I6G56_RS31040	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G56_RS31055	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G56_RS31080	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6G56_RS31085	COG1620	l-lactate permease
I6G56_RS31095	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6G56_RS31100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6G56_RS31105	COG2271	Major facilitator Superfamily
I6G56_RS31125	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G56_RS31140	COG1012	belongs to the aldehyde dehydrogenase family
I6G56_RS31175	COG0789	Transcriptional regulator
I6G56_RS31190	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6G56_RS31195	COG0667	Aldo Keto reductase
I6G56_RS31200	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS31210	COG0556	nucleotide-excision repair
I6G56_RS31220	COG4633	Protein conserved in bacteria
I6G56_RS31225	COG0672	)-iron permease
I6G56_RS31235	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6G56_RS31280	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I6G56_RS31315	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G56_RS31355	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G56_RS31365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G56_RS31390	COG1796	DNA polymerase
I6G56_RS31390	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
I6G56_RS31405	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G56_RS31410	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G56_RS31420	COG1177	transmembrane transport
I6G56_RS31425	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G56_RS31430	COG3842	ATPase activity
I6G56_RS31445	COG0174	glutamine synthetase
I6G56_RS31450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I6G56_RS31450	COG0519	Catalyzes the synthesis of GMP from XMP
I6G56_RS31455	COG1917	Cupin 2, conserved barrel domain protein
I6G56_RS31455	COG1396	sequence-specific DNA binding
I6G56_RS31460	COG1012	belongs to the aldehyde dehydrogenase family
I6G56_RS31465	COG0010	Belongs to the arginase family
I6G56_RS31470	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6G56_RS31495	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G56_RS31495	COG1116	anion transmembrane transporter activity
I6G56_RS31500	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G56_RS31505	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G56_RS31530	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I6G56_RS31545	COG0318	PFAM AMP-dependent synthetase and ligase
I6G56_RS31565	COG3634	alkyl hydroperoxide reductase activity
I6G56_RS31595	COG3321	synthase
I6G56_RS31595	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G56_RS31595	COG0300	oxidoreductase activity
I6G56_RS31595	COG4221	oxidoreductase activity
I6G56_RS31600	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G56_RS31600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G56_RS31600	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS31600	COG3321	synthase
I6G56_RS31600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G56_RS31605	COG3321	synthase
I6G56_RS31605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G56_RS31605	COG0300	oxidoreductase activity
I6G56_RS31605	COG4221	oxidoreductase activity
I6G56_RS31610	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G56_RS31610	COG4221	oxidoreductase activity
I6G56_RS31610	COG3321	synthase
I6G56_RS31610	COG1028	Short-chain dehydrogenase reductase Sdr
I6G56_RS31615	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6G56_RS31620	COG3425	synthase
I6G56_RS31625	COG1024	Enoyl-CoA hydratase
I6G56_RS31630	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G56_RS31635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G56_RS31655	COG2124	cytochrome p450
I6G56_RS31720	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6G56_RS31725	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6G56_RS31765	COG3038	cytochrome b561
I6G56_RS31775	COG4771	TonB-dependent receptor
I6G56_RS31795	COG3842	ATPase activity
I6G56_RS31805	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G56_RS31810	COG1177	transmembrane transport
I6G56_RS31840	COG2814	Major facilitator Superfamily
I6G56_RS31845	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6G56_RS31865	COG0039	L-malate dehydrogenase activity
I6G56_RS31870	COG2188	Transcriptional regulator
I6G56_RS31875	COG2009	succinate dehydrogenase
I6G56_RS31885	COG1053	succinate dehydrogenase
I6G56_RS31890	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G56_RS31895	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6G56_RS31900	COG0372	Belongs to the citrate synthase family
I6G56_RS31925	COG1522	sequence-specific DNA binding
I6G56_RS31970	COG0135	phosphoribosylanthranilate isomerase activity
I6G56_RS31975	COG0133	tryptophan synthase activity
I6G56_RS31990	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I6G56_RS31995	COG0285	dihydrofolate synthase activity
I6G56_RS32025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G56_RS32030	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6G56_RS32035	COG2755	lipolytic protein G-D-S-L family
I6G56_RS32035	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6G56_RS32070	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G56_RS32075	COG2755	lipolytic protein G-D-S-L family
I6G56_RS32075	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6G56_RS32085	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G56_RS32090	COG1295	ribonuclease BN
I6G56_RS32100	COG3608	succinylglutamate desuccinylase aspartoacylase
I6G56_RS32115	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G56_RS32195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G56_RS32200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G56_RS32205	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G56_RS32210	COG1126	abc transporter atp-binding protein
I6G56_RS32230	COG0437	4 iron, 4 sulfur cluster binding
I6G56_RS32235	COG2864	formate dehydrogenase
I6G56_RS32250	COG3276	selenocysteine insertion sequence binding
I6G56_RS32275	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6G56_RS32280	COG4789	Type iii secretion
I6G56_RS32310	COG5002	protein histidine kinase activity
I6G56_RS32310	COG3850	Histidine kinase
I6G56_RS32315	COG0745	RESPONSE REGULATOR receiver
I6G56_RS32370	COG1472	Belongs to the glycosyl hydrolase 3 family
I6G56_RS32390	COG2814	Major facilitator Superfamily
I6G56_RS32395	COG3621	Patatin-like phospholipase
I6G56_RS32430	COG2030	dehydratase
I6G56_RS32480	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6G56_RS32485	COG4789	Type iii secretion
I6G56_RS32505	COG4794	Type iii secretion
I6G56_RS32540	COG2207	Transcriptional regulator
I6G56_RS32685	COG1067	ATP-dependent peptidase activity