locus-tag	class	description
WK25_RS00010	COG0592	DNA-directed DNA polymerase activity
WK25_RS00035	COG4372	Transposase
WK25_RS00070	COG1024	Enoyl-CoA hydratase
WK25_RS00085	COG1024	Enoyl-CoA hydratase
WK25_RS00090	COG2050	protein possibly involved in aromatic compounds catabolism
WK25_RS00100	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
WK25_RS00105	COG2967	ApaG domain
WK25_RS00110	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WK25_RS00115	COG0546	phosphoglycolate phosphatase activity
WK25_RS00125	COG0512	Glutamine amidotransferase of anthranilate synthase
WK25_RS00130	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WK25_RS00135	COG0134	indole-3-glycerol-phosphate synthase activity
WK25_RS00145	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
WK25_RS00160	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WK25_RS00165	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WK25_RS00170	COG0012	GTP binding
WK25_RS00185	COG0488	(ABC) transporter
WK25_RS00195	COG1335	isochorismatase
WK25_RS00200	COG0006	proline dipeptidase activity
WK25_RS00210	COG0745	RESPONSE REGULATOR receiver
WK25_RS00225	COG2890	protein-(glutamine-N5) methyltransferase activity
WK25_RS00230	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
WK25_RS00240	COG3384	dioxygenase
WK25_RS00245	COG0531	amino acid
WK25_RS00250	COG1278	Cold shock
WK25_RS00255	COG0443	Heat shock 70 kDa protein
WK25_RS00270	COG1309	transcriptional regulator
WK25_RS00285	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
WK25_RS00295	COG0308	aminopeptidase N
WK25_RS00400	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WK25_RS00410	COG0583	DNA-binding transcription factor activity
WK25_RS00430	COG0582	viral genome integration into host DNA
WK25_RS00480	COG2969	positive regulation of protein catabolic process
WK25_RS00485	COG0625	glutathione transferase activity
WK25_RS00490	COG2857	Cytochrome c1
WK25_RS00495	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
WK25_RS00500	COG0723	plastoquinol--plastocyanin reductase activity
WK25_RS00505	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
WK25_RS00510	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WK25_RS00515	COG0805	protein transport
WK25_RS00520	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
WK25_RS00545	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
WK25_RS00550	COG0107	imidazoleglycerol-phosphate synthase activity
WK25_RS00565	COG2095	MarC family integral membrane protein
WK25_RS00570	COG0131	Imidazoleglycerol-phosphate dehydratase
WK25_RS00580	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
WK25_RS00600	COG0842	Transport permease protein
WK25_RS00605	COG1131	(ABC) transporter
WK25_RS00625	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WK25_RS00630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WK25_RS00635	COG1127	ABC transporter
WK25_RS00660	COG4178	(ABC) transporter
WK25_RS00665	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
WK25_RS00670	COG1115	amino acid carrier protein
WK25_RS00690	COG0070	glutamate synthase
WK25_RS00690	COG0069	glutamate synthase activity
WK25_RS00690	COG0067	glutamate synthase
WK25_RS00705	COG0584	glycerophosphoryl diester phosphodiesterase
WK25_RS00715	COG0395	ABC-type sugar transport system, permease component
WK25_RS00720	COG1175	transmembrane transport
WK25_RS00725	COG1653	transport
WK25_RS00730	COG0232	Belongs to the dGTPase family. Type 2 subfamily
WK25_RS00770	COG1965	Belongs to the frataxin family
WK25_RS00780	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
WK25_RS00785	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
WK25_RS00790	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
WK25_RS00795	COG1333	cytochrome c biogenesis protein
WK25_RS00815	COG4232	protein-disulfide reductase activity
WK25_RS00835	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
WK25_RS00845	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
WK25_RS00860	COG0201	protein transport
WK25_RS00865	COG0200	Binds to the 23S rRNA
WK25_RS00910	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
WK25_RS00915	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
WK25_RS00925	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
WK25_RS00960	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
WK25_RS00970	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WK25_RS00990	COG0514	ATP-dependent DNA helicase (RecQ)
WK25_RS00995	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
WK25_RS01000	COG0085	RNA polymerase activity
WK25_RS01015	COG0081	regulation of translation
WK25_RS01020	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
WK25_RS01030	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
WK25_RS01040	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
WK25_RS01090	COG3396	Phenylacetate-CoA oxygenase
WK25_RS01095	COG3460	Phenylacetate-CoA oxygenase
WK25_RS01100	COG3396	Phenylacetate-CoA oxygenase
WK25_RS01105	COG2151	metal-sulfur cluster biosynthetic enzyme
WK25_RS01110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WK25_RS01130	COG1522	sequence-specific DNA binding
WK25_RS01150	COG0281	malic enzyme
WK25_RS01150	COG0280	phosphate acetyltransferase
WK25_RS01155	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
WK25_RS01160	COG1881	PFAM PEBP family protein
WK25_RS01170	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
WK25_RS01185	COG3047	cAMP biosynthetic process
WK25_RS01195	COG2814	Major facilitator Superfamily
WK25_RS01200	COG1280	lysine exporter protein (LysE YggA)
WK25_RS01205	COG2084	Dehydrogenase
WK25_RS01225	COG1136	(ABC) transporter
WK25_RS01225	COG0577	efflux transmembrane transporter activity
WK25_RS01235	COG1136	(ABC) transporter
WK25_RS01235	COG0577	efflux transmembrane transporter activity
WK25_RS01245	COG2271	Major facilitator Superfamily
WK25_RS01275	COG2823	Periplasmic or secreted lipoprotein
WK25_RS01280	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
WK25_RS01285	COG0792	nuclease activity
WK25_RS01300	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WK25_RS01310	COG1522	sequence-specific DNA binding
WK25_RS01360	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
WK25_RS01365	COG1950	PFAM Membrane protein of
WK25_RS01375	COG1191	sigma factor activity
WK25_RS01390	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WK25_RS01395	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WK25_RS01400	COG3152	Membrane
WK25_RS01420	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
WK25_RS01425	COG0745	RESPONSE REGULATOR receiver
WK25_RS01440	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
WK25_RS01450	COG0835	chemotaxis
WK25_RS01460	COG0745	RESPONSE REGULATOR receiver
WK25_RS01465	COG1360	Flagellar Motor Protein
WK25_RS01485	COG0438	transferase activity, transferring glycosyl groups
WK25_RS01490	COG2916	Histone family protein nucleoid-structuring protein H-NS
WK25_RS01495	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WK25_RS01500	COG0561	phosphatase activity
WK25_RS01510	COG0519	Catalyzes the synthesis of GMP from XMP
WK25_RS01575	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WK25_RS01585	COG4106	trans-aconitate 2-methyltransferase activity
WK25_RS01590	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WK25_RS01700	COG4695	Portal protein
WK25_RS01710	COG3436	PFAM IS66 Orf2 family protein
WK25_RS01715	COG4372	Transposase
WK25_RS01720	COG3012	SEC-C Motif Domain Protein
WK25_RS01725	COG4695	Portal protein
WK25_RS01830	COG0863	Belongs to the N(4) N(6)-methyltransferase family
WK25_RS01910	COG0582	viral genome integration into host DNA
WK25_RS01960	COG3245	cytochrome
WK25_RS01965	COG0210	DNA helicase
WK25_RS01970	COG0673	inositol 2-dehydrogenase activity
WK25_RS01990	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WK25_RS01990	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
WK25_RS02000	COG1760	l-serine dehydratase
WK25_RS02010	COG0028	Belongs to the TPP enzyme family
WK25_RS02030	COG1012	belongs to the aldehyde dehydrogenase family
WK25_RS02045	COG0477	Major facilitator Superfamily
WK25_RS02050	COG0583	DNA-binding transcription factor activity
WK25_RS02055	COG4302	ethanolamine ammonia-lyase activity
WK25_RS02065	COG0531	amino acid
WK25_RS02070	COG0668	transmembrane transport
WK25_RS02090	COG0789	Transcriptional regulator
WK25_RS02105	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WK25_RS02110	COG0436	Aminotransferase
WK25_RS02120	COG1960	acyl-CoA dehydrogenase activity
WK25_RS02135	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WK25_RS02135	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WK25_RS02135	COG0506	proline dehydrogenase activity
WK25_RS02140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
WK25_RS02145	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
WK25_RS02155	COG0318	PFAM AMP-dependent synthetase and ligase
WK25_RS02170	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
WK25_RS02175	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
WK25_RS02195	COG0356	it plays a direct role in the translocation of protons across the membrane
WK25_RS02205	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
WK25_RS02210	COG1475	DNA binding
WK25_RS02215	COG1192	Involved in chromosome partitioning
WK25_RS02255	COG0559	Belongs to the binding-protein-dependent transport system permease family
WK25_RS02280	COG0583	DNA-binding transcription factor activity
WK25_RS02290	COG1522	sequence-specific DNA binding
WK25_RS02295	COG3186	Phenylalanine-4-hydroxylase
WK25_RS02300	COG2154	pterin-4-alpha-carbinolamine dehydratase
WK25_RS02315	COG0642	Histidine kinase
WK25_RS02325	COG1902	pentaerythritol trinitrate reductase activity
WK25_RS02330	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WK25_RS02330	COG0519	Catalyzes the synthesis of GMP from XMP
WK25_RS02350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WK25_RS02350	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
WK25_RS02360	COG0523	cobalamin synthesis protein
WK25_RS02380	COG1459	type II secretion system
WK25_RS02395	COG2165	general secretion pathway protein
WK25_RS02440	COG1846	Transcriptional regulator
WK25_RS02445	COG2814	Major facilitator Superfamily
WK25_RS02450	COG0583	DNA-binding transcription factor activity
WK25_RS02455	COG1380	Effector of murein hydrolase LrgA
WK25_RS02460	COG1346	cytolysis
WK25_RS02475	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
WK25_RS02485	COG1338	Plays a role in the flagellum-specific transport system
WK25_RS02490	COG1987	bacterial-type flagellum assembly
WK25_RS02510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WK25_RS02525	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
WK25_RS02555	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
WK25_RS02560	COG1262	PFAM Formylglycine-generating sulfatase enzyme
WK25_RS02565	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WK25_RS02600	COG3038	cytochrome b561
WK25_RS02620	COG0243	molybdopterin cofactor binding
WK25_RS02625	COG0318	PFAM AMP-dependent synthetase and ligase
WK25_RS02630	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
WK25_RS02635	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
WK25_RS02640	COG2001	Belongs to the MraZ family
WK25_RS02645	COG0275	rRNA processing
WK25_RS02650	COG3116	cell division
WK25_RS02660	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
WK25_RS02665	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
WK25_RS02675	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
WK25_RS02685	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
WK25_RS02690	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WK25_RS02695	COG1181	Belongs to the D-alanine--D-alanine ligase family
WK25_RS02700	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
WK25_RS02715	COG0678	peroxiredoxin activity
WK25_RS02720	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
WK25_RS02730	COG0653	protein targeting
WK25_RS02745	COG0494	nUDIX hydrolase
WK25_RS02750	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
WK25_RS02765	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
WK25_RS02780	COG4536	flavin adenine dinucleotide binding
WK25_RS02805	COG0142	geranyltranstransferase activity
WK25_RS02820	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
WK25_RS02845	COG2095	MarC family integral membrane protein
WK25_RS02850	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
WK25_RS02855	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
WK25_RS02870	COG3023	N-Acetylmuramoyl-L-alanine amidase
WK25_RS02895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WK25_RS02900	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
WK25_RS02915	COG0439	Biotin carboxylase
WK25_RS02920	COG0511	ligase activity, forming carbon-carbon bonds
WK25_RS02925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
WK25_RS02930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
WK25_RS02940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
WK25_RS02945	COG3150	esterase
WK25_RS02950	COG0557	exoribonuclease II activity
WK25_RS02955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WK25_RS02960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
WK25_RS02975	COG1414	Transcriptional regulator
WK25_RS02980	COG3734	2-keto-3-deoxy-galactonokinase
WK25_RS02985	COG0800	Aldolase
WK25_RS02990	COG1028	Short-chain dehydrogenase reductase Sdr
WK25_RS03000	COG1129	ABC transporter
WK25_RS03020	COG0284	orotidine-5'-phosphate decarboxylase activity
WK25_RS03030	COG1546	Belongs to the CinA family
WK25_RS03035	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
WK25_RS03050	COG4290	ribonuclease
WK25_RS03060	COG3547	Transposase (IS116 IS110 IS902 family)
WK25_RS03065	COG1385	rRNA (uridine-N3-)-methyltransferase activity
WK25_RS03075	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
WK25_RS03080	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
WK25_RS03085	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
WK25_RS03095	COG1301	dicarboxylic acid transport
WK25_RS03100	COG4266	Belongs to the allantoicase family
WK25_RS03105	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
WK25_RS03110	COG0735	belongs to the Fur family
WK25_RS03115	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WK25_RS03135	COG0495	leucyl-tRNA aminoacylation
WK25_RS03140	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
WK25_RS03145	COG1466	dna polymerase III delta subunit
WK25_RS03155	COG1981	membrane
WK25_RS03170	COG0800	Aldolase
WK25_RS03180	COG3265	gluconokinase activity
WK25_RS03190	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
WK25_RS03200	COG0583	DNA-binding transcription factor activity
WK25_RS03205	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
WK25_RS03210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WK25_RS03215	COG0765	amino acid transport
WK25_RS03220	COG0765	amino acid transport
WK25_RS03225	COG1126	abc transporter atp-binding protein
WK25_RS03235	COG0121	glutamine amidotransferase
WK25_RS03240	COG0418	dihydroorotase activity
WK25_RS03265	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
WK25_RS03270	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
WK25_RS03290	COG1490	D-aminoacyl-tRNA deacylase activity
WK25_RS03295	COG0588	phosphoglycerate mutase activity
WK25_RS03305	COG2255	four-way junction helicase activity
WK25_RS03315	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
WK25_RS03325	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
WK25_RS03330	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WK25_RS03335	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
WK25_RS03340	COG0006	proline dipeptidase activity
WK25_RS03345	COG0625	glutathione transferase activity
WK25_RS03350	COG0069	glutamate synthase activity
WK25_RS03405	COG3008	intermembrane lipid transfer
WK25_RS03405	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
WK25_RS03410	COG2995	paraquat-inducible protein a
WK25_RS03425	COG2353	YceI-like domain
WK25_RS03440	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WK25_RS03445	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
WK25_RS03450	COG1862	Preprotein translocase
WK25_RS03455	COG0343	queuine tRNA-ribosyltransferase activity
WK25_RS03465	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WK25_RS03475	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
WK25_RS03480	COG0783	Belongs to the Dps family
WK25_RS03485	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
WK25_RS03500	COG0247	lactate metabolic process
WK25_RS03505	COG0277	FAD linked oxidase domain protein
WK25_RS03510	COG0277	FAD linked oxidase domain protein
WK25_RS03515	COG0277	FAD linked oxidase domain protein
WK25_RS03520	COG2096	Adenosyltransferase
WK25_RS03525	COG1017	nitric oxide dioxygenase activity
WK25_RS03525	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WK25_RS03530	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
WK25_RS03535	COG0312	modulator of DNA gyrase
WK25_RS03540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
WK25_RS03550	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
WK25_RS03555	COG0497	DNA recombination
WK25_RS03560	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
WK25_RS03565	COG1420	regulation of RNA biosynthetic process
WK25_RS03570	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
WK25_RS03590	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WK25_RS03600	COG0443	Heat shock 70 kDa protein
WK25_RS03610	COG0512	Glutamine amidotransferase of anthranilate synthase
WK25_RS03610	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
WK25_RS03625	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
WK25_RS03630	COG0617	tRNA 3'-terminal CCA addition
WK25_RS03640	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
WK25_RS03645	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
WK25_RS03655	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
WK25_RS03660	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
WK25_RS03665	COG0586	Pfam SNARE associated Golgi protein
WK25_RS03680	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WK25_RS03705	COG0823	Involved in the tonB-independent uptake of proteins
WK25_RS03725	COG0824	Thioesterase
WK25_RS03730	COG4221	oxidoreductase activity
WK25_RS03740	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
WK25_RS03780	COG0450	alkyl hydroperoxide reductase
WK25_RS03785	COG1960	acyl-CoA dehydrogenase activity
WK25_RS03810	COG2814	Major facilitator Superfamily
WK25_RS03815	COG3508	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate
WK25_RS03835	COG2814	Major facilitator Superfamily
WK25_RS03840	COG0778	Nitroreductase
WK25_RS03845	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
WK25_RS03850	COG0583	DNA-binding transcription factor activity
WK25_RS03855	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
WK25_RS03885	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WK25_RS03930	COG0730	response to heat
WK25_RS04000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
WK25_RS04035	COG1773	rubredoxin
WK25_RS04055	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
WK25_RS04065	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
WK25_RS04105	COG0662	Cupin 2, conserved barrel domain protein
WK25_RS04105	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
WK25_RS04120	COG2226	methyltransferase
WK25_RS04135	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
WK25_RS04150	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WK25_RS04170	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
WK25_RS04175	COG0438	transferase activity, transferring glycosyl groups
WK25_RS04195	COG0859	PFAM glycosyl transferase family 9
WK25_RS04215	COG0830	nickel cation binding
WK25_RS04235	COG0831	urea catabolic process
WK25_RS04240	COG0829	nickel cation binding
WK25_RS04250	COG1129	ABC transporter
WK25_RS04260	COG0559	Belongs to the binding-protein-dependent transport system permease family
WK25_RS04275	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WK25_RS04285	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WK25_RS04300	COG1968	undecaprenyl-diphosphatase activity
WK25_RS04305	COG0220	tRNA (guanine-N7-)-methyltransferase activity
WK25_RS04385	COG4948	Mandelate Racemase Muconate Lactonizing
WK25_RS04405	COG0494	nUDIX hydrolase
WK25_RS04410	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
WK25_RS04425	COG0762	integral membrane protein
WK25_RS04445	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
WK25_RS04455	COG0436	Aminotransferase
WK25_RS04465	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
WK25_RS04485	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WK25_RS04485	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
WK25_RS04490	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
WK25_RS04500	COG2814	Major facilitator Superfamily
WK25_RS04510	COG0363	glucosamine-6-phosphate deaminase activity
WK25_RS04515	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
WK25_RS04525	COG1175	transmembrane transport
WK25_RS04530	COG0395	ABC-type sugar transport system, permease component
WK25_RS04535	COG3842	ATPase activity
WK25_RS04550	COG2860	membrane
WK25_RS04555	COG1193	negative regulation of DNA recombination
WK25_RS04560	COG0492	ferredoxin-NADP+ reductase activity
WK25_RS04565	COG1674	ftsk spoiiie
WK25_RS04570	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
WK25_RS04575	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
WK25_RS04615	COG2894	cell division
WK25_RS04620	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
WK25_RS04635	COG0859	PFAM glycosyl transferase family 9
WK25_RS04645	COG0477	Major facilitator Superfamily
WK25_RS04670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
WK25_RS04675	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
WK25_RS04685	COG1561	YicC-like family, N-terminal region
WK25_RS04700	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WK25_RS04725	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
WK25_RS04735	COG1278	Cold shock
WK25_RS04740	COG1199	ATP-dependent helicase activity
WK25_RS04740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
WK25_RS04755	COG4772	TonB-dependent receptor
WK25_RS04780	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
WK25_RS04785	COG0308	aminopeptidase N
WK25_RS04795	COG2119	membrane
WK25_RS04800	COG0402	S-adenosylhomocysteine deaminase activity
WK25_RS04810	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
WK25_RS04820	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
WK25_RS04835	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
WK25_RS04870	COG3383	formate dehydrogenase (NAD+) activity
WK25_RS04885	COG1910	domain protein
WK25_RS04905	COG0546	phosphoglycolate phosphatase activity
WK25_RS04940	COG0287	Prephenate dehydrogenase
WK25_RS04950	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
WK25_RS04960	COG0776	regulation of translation
WK25_RS04970	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
WK25_RS04980	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
WK25_RS04985	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WK25_RS05000	COG2951	lytic endotransglycosylase activity
WK25_RS05005	COG0123	including yeast histone deacetylase and acetoin utilization protein
WK25_RS05010	COG2267	carboxylic ester hydrolase activity
WK25_RS05015	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
WK25_RS05020	COG2011	ABC-type metal ion transport system permease component
WK25_RS05070	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
WK25_RS05075	COG0336	Belongs to the RNA methyltransferase TrmD family
WK25_RS05080	COG0335	large ribosomal subunit rRNA binding
WK25_RS05105	COG0501	Belongs to the peptidase M48B family
WK25_RS05110	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
WK25_RS05115	COG0521	Mo-molybdopterin cofactor biosynthetic process
WK25_RS05120	COG3028	Belongs to the UPF0307 family
WK25_RS05125	COG0312	modulator of DNA gyrase
WK25_RS05130	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
WK25_RS05140	COG2204	response regulator
WK25_RS05145	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
WK25_RS05170	COG0114	fumarate hydratase activity
WK25_RS05200	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
WK25_RS05210	COG3045	CreA protein
WK25_RS05225	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
WK25_RS05230	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
WK25_RS05250	COG1322	Protein conserved in bacteria
WK25_RS05275	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
WK25_RS05280	COG1530	ribonuclease E activity
WK25_RS05290	COG0546	phosphoglycolate phosphatase activity
WK25_RS05300	COG0616	signal peptide processing
WK25_RS05315	COG1399	metal-binding, possibly nucleic acid-binding protein
WK25_RS05325	COG0416	fatty acid biosynthetic process
WK25_RS05350	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
WK25_RS05360	COG1595	DNA-templated transcription, initiation
WK25_RS05375	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WK25_RS05385	COG0481	GTPase activity
WK25_RS05390	COG0681	Belongs to the peptidase S26 family
WK25_RS05395	COG0571	ribonuclease III activity
WK25_RS05400	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WK25_RS05430	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
WK25_RS05485	COG0024	Methionine aminopeptidase
WK25_RS05490	COG1956	GAF domain-containing protein
WK25_RS05505	COG2153	protein acetylation
WK25_RS05520	COG1999	signal sequence binding
WK25_RS05530	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
WK25_RS05535	COG1132	(ABC) transporter
WK25_RS05540	COG0438	transferase activity, transferring glycosyl groups
WK25_RS05570	COG3511	phospholipase C
WK25_RS05580	COG0596	Alpha beta hydrolase
WK25_RS05585	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
WK25_RS05600	COG3394	polysaccharide catabolic process
WK25_RS05635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WK25_RS05650	COG1012	belongs to the aldehyde dehydrogenase family
WK25_RS05660	COG2988	succinylglutamate desuccinylase activity
WK25_RS05680	COG0450	alkyl hydroperoxide reductase
WK25_RS05700	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WK25_RS05725	COG0004	ammonium transporteR
WK25_RS05740	COG1959	2 iron, 2 sulfur cluster binding
WK25_RS05750	COG1522	sequence-specific DNA binding
WK25_RS05755	COG3842	ATPase activity
WK25_RS05760	COG1178	ABC-type Fe3 transport system permease component
WK25_RS05765	COG1840	ABC-type Fe3 transport system, periplasmic component
WK25_RS05775	COG1289	transmembrane transporter activity
WK25_RS05780	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
WK25_RS05785	COG1074	ATP-dependent DNA helicase activity
WK25_RS05790	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
WK25_RS05800	COG2200	EAL domain
WK25_RS05820	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
WK25_RS05830	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
WK25_RS05835	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
WK25_RS05850	COG0697	spore germination
WK25_RS05855	COG2814	Major facilitator Superfamily
WK25_RS05860	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
WK25_RS05865	COG3842	ATPase activity
WK25_RS05870	COG1177	transmembrane transport
WK25_RS05880	COG1840	ABC-type Fe3 transport system, periplasmic component
WK25_RS05885	COG1609	Transcriptional regulator
WK25_RS05890	COG0582	viral genome integration into host DNA
WK25_RS06055	COG1783	phage Terminase large subunit
WK25_RS06220	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WK25_RS06230	COG0022	dehydrogenase e1 component
WK25_RS06245	COG0702	epimerase
WK25_RS06255	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
WK25_RS06260	COG0583	DNA-binding transcription factor activity
WK25_RS06265	COG0477	Major facilitator Superfamily
WK25_RS06280	COG2814	Major facilitator Superfamily
WK25_RS06285	COG0583	DNA-binding transcription factor activity
WK25_RS06300	COG0583	DNA-binding transcription factor activity
WK25_RS06305	COG1253	flavin adenine dinucleotide binding
WK25_RS06325	COG1250	3-hydroxyacyl-CoA dehydrogenase
WK25_RS06335	COG0583	DNA-binding transcription factor activity
WK25_RS06355	COG3052	prosthetic group binding
WK25_RS06375	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
WK25_RS06410	COG0477	Major facilitator Superfamily
WK25_RS06425	COG0328	RNA-DNA hybrid ribonuclease activity
WK25_RS06430	COG2226	methyltransferase
WK25_RS06435	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
WK25_RS06440	COG0741	lytic transglycosylase activity
WK25_RS06440	COG1388	LysM domain
WK25_RS06450	COG0505	Belongs to the CarA family
WK25_RS06460	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WK25_RS06465	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
WK25_RS06475	COG1534	Rna-binding protein
WK25_RS06480	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
WK25_RS06485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WK25_RS06495	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
WK25_RS06500	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
WK25_RS06505	COG0573	inorganic phosphate transmembrane transporter activity
WK25_RS06510	COG0581	inorganic phosphate transmembrane transporter activity
WK25_RS06525	COG0745	RESPONSE REGULATOR receiver
WK25_RS06585	COG0534	Mate efflux family protein
WK25_RS06595	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
WK25_RS06600	COG4942	peptidase
WK25_RS06640	COG2205	protein histidine kinase activity
WK25_RS06645	COG0745	RESPONSE REGULATOR receiver
WK25_RS06665	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
WK25_RS06670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WK25_RS06675	COG0583	DNA-binding transcription factor activity
WK25_RS06680	COG2851	Citrate transporter
WK25_RS06695	COG0840	transmembrane signaling receptor activity
WK25_RS06700	COG4589	Belongs to the CDS family
WK25_RS06710	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
WK25_RS06720	COG1215	transferase activity, transferring glycosyl groups
WK25_RS06725	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
WK25_RS06750	COG1215	transferase activity, transferring glycosyl groups
WK25_RS06755	COG2194	sulfuric ester hydrolase activity
WK25_RS06765	COG1741	Belongs to the pirin family
WK25_RS06775	COG0025	NhaP-type Na H and K H
WK25_RS06790	COG0583	DNA-binding transcription factor activity
WK25_RS06800	COG1574	metal-dependent hydrolase with the TIM-barrel fold
WK25_RS06830	COG1858	cytochrome C peroxidase
WK25_RS06850	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
WK25_RS06865	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WK25_RS06880	COG0477	Major facilitator Superfamily
WK25_RS06885	COG2816	NAD+ diphosphatase activity
WK25_RS06890	COG0824	Thioesterase
WK25_RS06920	COG1028	Short-chain dehydrogenase reductase Sdr
WK25_RS06925	COG4702	Belongs to the UPF0303 family
WK25_RS06930	COG3718	enzyme involved in inositol metabolism
WK25_RS06940	COG3962	Belongs to the TPP enzyme family
WK25_RS06955	COG1129	ABC transporter
WK25_RS06960	COG1172	Belongs to the binding-protein-dependent transport system permease family
WK25_RS06965	COG1082	Xylose isomerase domain protein TIM barrel
WK25_RS06970	COG0673	inositol 2-dehydrogenase activity
WK25_RS06980	COG0673	inositol 2-dehydrogenase activity
WK25_RS06985	COG1737	Transcriptional regulator
WK25_RS07000	COG0425	Belongs to the sulfur carrier protein TusA family
WK25_RS07010	COG0745	RESPONSE REGULATOR receiver
WK25_RS07020	COG5002	protein histidine kinase activity
WK25_RS07030	COG1210	Utp--glucose-1-phosphate uridylyltransferase
WK25_RS07035	COG0525	valine-tRNA ligase activity
WK25_RS07040	COG0210	DNA helicase
WK25_RS07045	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
WK25_RS07050	COG2223	nitrite transmembrane transporter activity
WK25_RS07055	COG0840	transmembrane signaling receptor activity
WK25_RS07080	COG0583	DNA-binding transcription factor activity
WK25_RS07090	COG0277	FAD linked oxidase domain protein
WK25_RS07105	COG1295	ribonuclease BN
WK25_RS07120	COG0477	Major facilitator Superfamily
WK25_RS07135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WK25_RS07140	COG2271	Major facilitator Superfamily
WK25_RS07155	COG1028	Short-chain dehydrogenase reductase Sdr
WK25_RS07180	COG1028	Short-chain dehydrogenase reductase Sdr
WK25_RS07195	COG0583	DNA-binding transcription factor activity
WK25_RS07205	COG0251	oxidation-reduction process
WK25_RS07210	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
WK25_RS07220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
WK25_RS07225	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
WK25_RS07240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
WK25_RS07250	COG0776	regulation of translation
WK25_RS07345	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
WK25_RS07385	COG0583	DNA-binding transcription factor activity
WK25_RS07390	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
WK25_RS07400	COG0779	Required for maturation of 30S ribosomal subunits
WK25_RS07405	COG2251	uridine kinase activity
WK25_RS07405	COG0195	Participates in both transcription termination and antitermination
WK25_RS07410	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
WK25_RS07425	COG2814	Major facilitator Superfamily
WK25_RS07430	COG1566	PFAM secretion protein HlyD family protein
WK25_RS07440	COG1846	Transcriptional regulator
WK25_RS07445	COG1217	gtp-binding protein TYPA
WK25_RS07450	COG0567	Dehydrogenase, E1 component
WK25_RS07455	COG0508	dehydrogenase complex catalyzes the overall conversion of
WK25_RS07460	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WK25_RS07465	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
WK25_RS07515	COG4964	Belongs to the GSP D family
WK25_RS07580	COG0318	PFAM AMP-dependent synthetase and ligase
WK25_RS07590	COG2814	Major facilitator Superfamily
WK25_RS07595	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WK25_RS07615	COG1879	ABC-type sugar transport system periplasmic component
WK25_RS07620	COG1172	Belongs to the binding-protein-dependent transport system permease family
WK25_RS07625	COG1129	ABC transporter
WK25_RS07645	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
WK25_RS07655	COG0557	exoribonuclease II activity
WK25_RS07660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WK25_RS07665	COG3023	N-Acetylmuramoyl-L-alanine amidase
WK25_RS07670	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
WK25_RS07680	COG0673	inositol 2-dehydrogenase activity
WK25_RS07685	COG0765	amino acid transport
WK25_RS07690	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WK25_RS07695	COG0167	dihydroorotate dehydrogenase activity
WK25_RS07700	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
WK25_RS07745	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WK25_RS07750	COG1116	anion transmembrane transporter activity
WK25_RS07770	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
WK25_RS07830	COG0667	Aldo Keto reductase
WK25_RS07845	COG0583	DNA-binding transcription factor activity
WK25_RS07850	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
WK25_RS07855	COG0701	Predicted permease
WK25_RS07890	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
WK25_RS07895	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
WK25_RS07900	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
WK25_RS07905	COG4208	sulfate ABC transporter
WK25_RS07910	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WK25_RS07915	COG0583	DNA-binding transcription factor activity
WK25_RS07920	COG1879	ABC-type sugar transport system periplasmic component
WK25_RS07925	COG1129	ABC transporter
WK25_RS07930	COG1172	Belongs to the binding-protein-dependent transport system permease family
WK25_RS07935	COG1609	Transcriptional regulator
WK25_RS07940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WK25_RS07950	COG2766	serine protein kinase
WK25_RS07955	COG2718	Belongs to the UPF0229 family
WK25_RS07960	COG2719	SpoVR family
WK25_RS07965	COG0477	Major facilitator Superfamily
WK25_RS07970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WK25_RS07980	COG0765	amino acid transport
WK25_RS07985	COG0739	heme binding
WK25_RS07990	COG1309	transcriptional regulator
WK25_RS08000	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WK25_RS08015	COG3188	usher protein
WK25_RS08020	COG3121	Chaperone
WK25_RS08050	COG1120	ATPase activity
WK25_RS08080	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WK25_RS08090	COG3486	L-lysine 6-monooxygenase (NADPH) activity
WK25_RS08095	COG4774	siderophore transport
WK25_RS08100	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WK25_RS08120	COG1473	amidohydrolase
WK25_RS08145	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
WK25_RS08160	COG1239	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX
WK25_RS08205	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
WK25_RS08210	COG2099	Precorrin-6x reductase
WK25_RS08220	COG2807	transmembrane transport
WK25_RS08225	COG1846	Transcriptional regulator
WK25_RS08230	COG0625	glutathione transferase activity
WK25_RS08240	COG3842	ATPase activity
WK25_RS08245	COG1176	ABC-type spermidine putrescine transport system, permease component I
WK25_RS08270	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WK25_RS08275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WK25_RS08295	COG2271	Major facilitator Superfamily
WK25_RS08320	COG2070	2-Nitropropane dioxygenase
WK25_RS08330	COG1846	Transcriptional regulator
WK25_RS08345	COG1764	response to oxidative stress
WK25_RS08355	COG0583	DNA-binding transcription factor activity
WK25_RS08360	COG1028	Short-chain dehydrogenase reductase Sdr
WK25_RS08385	COG0598	Magnesium transport protein CorA
WK25_RS08395	COG1122	ATPase activity
WK25_RS08410	COG3547	Transposase (IS116 IS110 IS902 family)
WK25_RS08435	COG1609	Transcriptional regulator
WK25_RS08450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WK25_RS08465	COG2855	membrane
WK25_RS08470	COG0038	chloride channel
WK25_RS08485	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WK25_RS08515	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WK25_RS08515	COG0730	response to heat
WK25_RS08520	COG1177	transmembrane transport
WK25_RS08525	COG1176	ABC-type spermidine putrescine transport system, permease component I
WK25_RS08530	COG3842	ATPase activity
WK25_RS08535	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
WK25_RS08545	COG3047	cAMP biosynthetic process
WK25_RS08550	COG2070	2-Nitropropane dioxygenase
WK25_RS08565	COG1522	sequence-specific DNA binding
WK25_RS08575	COG0488	(ABC) transporter
WK25_RS08585	COG2982	Protein involved in outer membrane biogenesis
WK25_RS08590	COG1122	ATPase activity
WK25_RS08595	COG0390	transport system, permease component
WK25_RS08610	COG0583	DNA-binding transcription factor activity
WK25_RS08615	COG0560	Phosphoserine phosphatase
WK25_RS08620	COG0626	cystathionine gamma-synthase activity
WK25_RS08650	COG1028	Short-chain dehydrogenase reductase Sdr
WK25_RS08655	COG0183	Belongs to the thiolase family
WK25_RS08660	COG3243	poly(R)-hydroxyalkanoic acid synthase
WK25_RS08670	COG0564	pseudouridine synthase activity
WK25_RS08680	COG1199	ATP-dependent helicase activity
WK25_RS08695	COG2183	response to ionizing radiation
WK25_RS08705	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
WK25_RS08715	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
WK25_RS08725	COG0330	HflC and HflK could
WK25_RS08730	COG0330	HflC and HflK could
WK25_RS08735	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
WK25_RS08745	COG1160	GTP binding
WK25_RS08755	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
WK25_RS08770	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
WK25_RS08780	COG0820	rRNA (adenine-C2-)-methyltransferase activity
WK25_RS08790	COG0670	Belongs to the BI1 family
WK25_RS08820	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
WK25_RS08825	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
WK25_RS08830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WK25_RS08840	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
WK25_RS08845	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
WK25_RS08865	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
WK25_RS08880	COG3228	Belongs to the MtfA family
WK25_RS08885	COG0254	rRNA binding
WK25_RS08895	COG0534	Mate efflux family protein
WK25_RS08900	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
WK25_RS08910	COG0022	dehydrogenase e1 component
WK25_RS08915	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
WK25_RS08920	COG3199	ATP-NAD kinase
WK25_RS08925	COG3284	Transcriptional regulator
WK25_RS08950	COG0542	response to heat
WK25_RS08955	COG1959	2 iron, 2 sulfur cluster binding
WK25_RS08960	COG2346	COG2346, Truncated hemoglobins
WK25_RS08965	COG0314	molybdopterin synthase activity
WK25_RS08970	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
WK25_RS08990	COG0436	Aminotransferase
WK25_RS09000	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
WK25_RS09005	COG2076	Multidrug Resistance protein
WK25_RS09010	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WK25_RS09025	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WK25_RS09025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
WK25_RS09030	COG0726	polysaccharide deacetylase
WK25_RS09035	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
WK25_RS09040	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
WK25_RS09045	COG0791	NLP P60 protein
WK25_RS09050	COG0306	phosphate transporter
WK25_RS09075	COG2965	DNA replication, synthesis of RNA primer
WK25_RS09080	COG0360	Binds together with S18 to 16S ribosomal RNA
WK25_RS09095	COG0583	DNA-binding transcription factor activity
WK25_RS09100	COG3960	tartronate-semialdehyde synthase activity
WK25_RS09105	COG3622	Belongs to the hyi family
WK25_RS09110	COG2084	Dehydrogenase
WK25_RS09115	COG1652	LysM domain
WK25_RS09120	COG0252	asparaginase activity
WK25_RS09140	COG0438	transferase activity, transferring glycosyl groups
WK25_RS09165	COG0084	hydrolase, TatD family'
WK25_RS09180	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
WK25_RS09195	COG2153	protein acetylation
WK25_RS09215	COG1309	transcriptional regulator
WK25_RS09225	COG0583	DNA-binding transcription factor activity
WK25_RS09245	COG1113	amino acid transport
WK25_RS09260	COG0183	Belongs to the thiolase family
WK25_RS09265	COG1335	isochorismatase
WK25_RS09275	COG0318	PFAM AMP-dependent synthetase and ligase
WK25_RS09285	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WK25_RS09300	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WK25_RS09310	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
WK25_RS09310	COG0047	phosphoribosylformylglycinamidine synthase activity
WK25_RS09315	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WK25_RS09320	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
WK25_RS09320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
WK25_RS09330	COG4181	ATPase activity
WK25_RS09340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
WK25_RS09355	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WK25_RS09370	COG0544	peptidyl-prolyl cis-trans isomerase activity
WK25_RS09375	COG1929	Belongs to the glycerate kinase type-1 family
WK25_RS09390	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
WK25_RS09440	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
WK25_RS09445	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
WK25_RS09450	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
WK25_RS09455	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
WK25_RS09460	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
WK25_RS09500	COG3360	Dodecin
WK25_RS09515	COG2351	hydroxyisourate hydrolase activity
WK25_RS09535	COG4266	Belongs to the allantoicase family
WK25_RS09540	COG3195	allantoin biosynthetic process
WK25_RS09540	COG3648	Uricase
WK25_RS09555	COG1953	Uracil, thiamine, allantoin
WK25_RS09565	COG1619	proteins homologs of microcin C7 resistance protein MccF
WK25_RS09570	COG0590	tRNA wobble adenosine to inosine editing
WK25_RS09580	COG2814	Major facilitator Superfamily
WK25_RS09590	COG0518	GMP synthase (glutamine-hydrolyzing) activity
WK25_RS09590	COG0519	Catalyzes the synthesis of GMP from XMP
WK25_RS09625	COG0697	spore germination
WK25_RS09645	COG0330	HflC and HflK could
WK25_RS09660	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
WK25_RS09665	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
WK25_RS09675	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WK25_RS09690	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WK25_RS09695	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
WK25_RS09705	COG0750	zinc metalloprotease
WK25_RS09720	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
WK25_RS09725	COG0233	cytoplasmic translational termination
WK25_RS09730	COG0528	UMP kinase activity
WK25_RS09735	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
WK25_RS09740	COG0052	Belongs to the universal ribosomal protein uS2 family
WK25_RS09745	COG0024	Methionine aminopeptidase
WK25_RS09755	COG1187	pseudouridine synthase activity
WK25_RS09760	COG0242	peptide deformylase activity
WK25_RS09795	COG1393	Belongs to the ArsC family
WK25_RS09805	COG2890	protein-(glutamine-N5) methyltransferase activity
WK25_RS09815	COG0386	Belongs to the glutathione peroxidase family
WK25_RS09820	COG0488	(ABC) transporter
WK25_RS09840	COG0477	Major facilitator Superfamily
WK25_RS09855	COG1573	uracil-dna glycosylase
WK25_RS09865	COG1214	PFAM Peptidase M22, glycoprotease
WK25_RS09875	COG0513	Belongs to the DEAD box helicase family
WK25_RS09880	COG2224	Isocitrate lyase
WK25_RS09890	COG0583	DNA-binding transcription factor activity
WK25_RS09900	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
WK25_RS09960	COG1752	Esterase of the alpha-beta hydrolase superfamily
WK25_RS09965	COG0791	NLP P60 protein
WK25_RS09970	COG4172	Belongs to the ABC transporter superfamily
WK25_RS09975	COG4239	(ABC) transporter, permease
WK25_RS09980	COG4174	ABC transporter (Permease)
WK25_RS09995	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
WK25_RS10035	COG0037	tRNA processing
WK25_RS10050	COG0215	cysteine-tRNA ligase activity
WK25_RS10060	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
WK25_RS10070	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
WK25_RS10075	COG1045	serine acetyltransferase
WK25_RS10085	COG0483	inositol monophosphate 1-phosphatase activity
WK25_RS10095	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
WK25_RS10100	COG2860	membrane
WK25_RS10105	COG1473	amidohydrolase
WK25_RS10135	COG2850	peptidyl-arginine hydroxylation
WK25_RS10140	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
WK25_RS10145	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
WK25_RS10150	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WK25_RS10160	COG0180	Tryptophanyl-tRNA synthetase
WK25_RS10165	COG1994	Peptidase M50
WK25_RS10170	COG0009	L-threonylcarbamoyladenylate synthase
WK25_RS10175	COG0613	PHP domain protein
WK25_RS10180	COG0596	Alpha beta hydrolase
WK25_RS10185	COG2833	Protein of unknown function (DUF455)
WK25_RS10195	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
WK25_RS10205	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
WK25_RS10210	COG0148	phosphopyruvate hydratase activity
WK25_RS10230	COG0658	competence protein
WK25_RS10230	COG2333	competence protein COMEC
WK25_RS10235	COG0084	hydrolase, TatD family'
WK25_RS10255	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
WK25_RS10260	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
WK25_RS10295	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
WK25_RS10300	COG0316	Belongs to the HesB IscA family
WK25_RS10305	COG0822	iron-sulfur transferase activity
WK25_RS10310	COG1104	cysteine desulfurase activity
WK25_RS10320	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
WK25_RS10340	COG1414	Transcriptional regulator
WK25_RS10355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WK25_RS10360	COG0508	dehydrogenase complex catalyzes the overall conversion of
WK25_RS10365	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
WK25_RS10375	COG4566	intracellular signal transduction
WK25_RS10385	COG0339	signal peptide processing
WK25_RS10390	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
WK25_RS10395	COG1794	racemase activity, acting on amino acids and derivatives
WK25_RS10410	COG1505	serine-type exopeptidase activity
WK25_RS10420	COG3852	Histidine kinase
WK25_RS10425	COG0174	glutamine synthetase
WK25_RS10435	COG1546	Belongs to the CinA family
WK25_RS10435	COG1058	Belongs to the CinA family
WK25_RS10455	COG1643	Atp-dependent helicase
WK25_RS10460	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
WK25_RS10460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
WK25_RS10470	COG0477	Major facilitator Superfamily
WK25_RS10475	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WK25_RS10480	COG1960	acyl-CoA dehydrogenase activity
WK25_RS10485	COG0583	DNA-binding transcription factor activity
WK25_RS10490	COG1113	amino acid transport
WK25_RS10495	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
WK25_RS10505	COG1448	Aminotransferase
WK25_RS10525	COG0174	glutamine synthetase
WK25_RS10530	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
WK25_RS10560	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
WK25_RS10570	COG2986	histidine ammonia-lyase
WK25_RS10590	COG0583	DNA-binding transcription factor activity
WK25_RS10595	COG2814	Major facilitator Superfamily
WK25_RS10655	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WK25_RS10690	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
WK25_RS10740	COG0672	)-iron permease
WK25_RS10745	COG4633	Protein conserved in bacteria
WK25_RS10755	COG0556	nucleotide-excision repair
WK25_RS10770	COG1028	Short-chain dehydrogenase reductase Sdr
WK25_RS10775	COG0667	Aldo Keto reductase
WK25_RS10780	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
WK25_RS10840	COG2866	Carboxypeptidase
WK25_RS10845	COG3022	response to hydroperoxide
WK25_RS10855	COG0436	Aminotransferase
WK25_RS10865	COG1024	Enoyl-CoA hydratase
WK25_RS10870	COG0625	glutathione transferase activity
WK25_RS10885	COG1960	acyl-CoA dehydrogenase activity
WK25_RS10890	COG1960	acyl-CoA dehydrogenase activity
WK25_RS10910	COG1007	ATP synthesis coupled electron transport
WK25_RS10935	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
WK25_RS10940	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
WK25_RS10945	COG1034	ATP synthesis coupled electron transport
WK25_RS10945	COG1034	ATP synthesis coupled electron transport
WK25_RS10955	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
WK25_RS10960	COG0649	NAD binding
WK25_RS10990	COG0149	triose-phosphate isomerase activity
WK25_RS10995	COG4221	oxidoreductase activity
WK25_RS10995	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
WK25_RS10995	COG3321	synthase
WK25_RS10995	COG0604	alcohol dehydrogenase
WK25_RS11000	COG1185	polyribonucleotide nucleotidyltransferase activity
WK25_RS11010	COG0683	leucine binding
WK25_RS11020	COG0288	reversible hydration of carbon dioxide
WK25_RS11025	COG0659	secondary active sulfate transmembrane transporter activity
WK25_RS11035	COG1183	phosphatidylcholine synthase activity
WK25_RS11040	COG0688	phosphatidylethanolamine metabolic process
WK25_RS11045	COG3344	reverse transcriptase
WK25_RS11050	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
WK25_RS11060	COG0028	Belongs to the TPP enzyme family
WK25_RS11090	COG0438	transferase activity, transferring glycosyl groups
WK25_RS11110	COG1028	Short-chain dehydrogenase reductase Sdr
WK25_RS11125	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
WK25_RS11145	COG2076	Multidrug Resistance protein
WK25_RS11155	COG0745	RESPONSE REGULATOR receiver
WK25_RS11160	COG2205	protein histidine kinase activity
WK25_RS11170	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
WK25_RS11175	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
WK25_RS11200	COG1028	Short-chain dehydrogenase reductase Sdr
WK25_RS11205	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
WK25_RS11210	COG0217	transcriptional regulatory protein
WK25_RS11215	COG0151	Belongs to the GarS family
WK25_RS11230	COG0799	negative regulation of ribosome biogenesis
WK25_RS11235	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
WK25_RS11245	COG1530	ribonuclease E activity
WK25_RS11250	COG3171	Protein conserved in bacteria
WK25_RS11290	COG0463	Glycosyl transferase, family 2
WK25_RS11305	COG0859	PFAM glycosyl transferase family 9
WK25_RS11325	COG0513	Belongs to the DEAD box helicase family
WK25_RS11330	COG3895	Periplasmic Protein
WK25_RS11340	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
WK25_RS11350	COG1674	ftsk spoiiie
WK25_RS11350	COG1674	ftsk spoiiie
WK25_RS11355	COG2706	6-phosphogluconolactonase activity
WK25_RS11360	COG3387	PFAM Glycoside hydrolase 15-related
WK25_RS11370	COG1309	transcriptional regulator
WK25_RS11375	COG2878	Part of a membrane complex involved in electron transport
WK25_RS11380	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
WK25_RS11410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
WK25_RS11420	COG3135	benzoate transporter
WK25_RS11480	COG0697	spore germination
WK25_RS11485	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
WK25_RS11495	COG0384	phenazine biosynthesis protein PhzF
WK25_RS11515	COG0583	DNA-binding transcription factor activity
WK25_RS11535	COG0488	(ABC) transporter
WK25_RS11570	COG1028	Short-chain dehydrogenase reductase Sdr
WK25_RS11595	COG2814	Major facilitator Superfamily
WK25_RS11605	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
WK25_RS11625	COG1116	anion transmembrane transporter activity
WK25_RS11630	COG1176	ABC-type spermidine putrescine transport system, permease component I
WK25_RS11655	COG1741	Belongs to the pirin family
WK25_RS11675	COG4598	ABC transporter
WK25_RS11710	COG2827	Endonuclease containing a URI domain
WK25_RS11715	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
WK25_RS11730	COG2271	Major facilitator Superfamily
WK25_RS11745	COG0181	hydroxymethylbilane synthase activity
WK25_RS11750	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
WK25_RS11755	COG2226	methyltransferase
WK25_RS11780	COG3188	usher protein
WK25_RS11785	COG0165	Argininosuccinate lyase
WK25_RS11790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WK25_RS11815	COG0489	protein tyrosine kinase activity
WK25_RS11820	COG3047	cAMP biosynthetic process
WK25_RS11820	COG2885	chlorophyll binding
WK25_RS11845	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
WK25_RS11855	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
WK25_RS11865	COG2259	Doxx family
WK25_RS11870	COG1492	cobalamin metabolic process
WK25_RS11880	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
WK25_RS11890	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
WK25_RS11900	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
WK25_RS11905	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
WK25_RS11910	COG1120	ATPase activity
WK25_RS11915	COG4139	cobalamin transport
WK25_RS11950	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
WK25_RS11955	COG0583	DNA-binding transcription factor activity
WK25_RS12000	COG1648	precorrin-2 dehydrogenase activity
WK25_RS12000	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
WK25_RS12005	COG2895	sulfate adenylyltransferase (ATP) activity
WK25_RS12015	COG0175	sulfate reduction
WK25_RS12030	COG0583	DNA-binding transcription factor activity
WK25_RS12050	COG1028	Short-chain dehydrogenase reductase Sdr
WK25_RS12055	COG1028	Short-chain dehydrogenase reductase Sdr
WK25_RS12060	COG0583	DNA-binding transcription factor activity
WK25_RS12070	COG1187	pseudouridine synthase activity
WK25_RS12085	COG0543	2 iron, 2 sulfur cluster binding
WK25_RS12085	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WK25_RS12090	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
WK25_RS12095	COG0456	acetyltransferase
WK25_RS12130	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
WK25_RS12135	COG1047	Peptidyl-prolyl cis-trans
WK25_RS12140	COG2003	Belongs to the UPF0758 family
WK25_RS12155	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
WK25_RS12165	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
WK25_RS12175	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
WK25_RS12175	COG3264	Mechanosensitive ion channel
WK25_RS12180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WK25_RS12180	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WK25_RS12185	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
WK25_RS12190	COG0196	riboflavin kinase activity
WK25_RS12200	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
WK25_RS12205	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
WK25_RS12210	COG0756	dUTP diphosphatase activity
WK25_RS12220	COG1113	amino acid transport
WK25_RS12225	COG0542	response to heat
WK25_RS12235	COG1278	Cold shock
WK25_RS12275	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
WK25_RS12285	COG0656	L-ascorbic acid biosynthetic process
WK25_RS12290	COG2188	Transcriptional regulator
WK25_RS12295	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WK25_RS12310	COG3547	Transposase (IS116 IS110 IS902 family)
WK25_RS12315	COG2814	Major facilitator Superfamily
WK25_RS12325	COG0500	methyltransferase
WK25_RS12345	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
WK25_RS12350	COG1570	exodeoxyribonuclease VII activity
WK25_RS12360	COG2835	tetraacyldisaccharide 4'-kinase activity
WK25_RS12370	COG0563	adenylate kinase activity
WK25_RS12385	COG0728	peptidoglycan biosynthetic process
WK25_RS12410	COG1666	GTP binding
WK25_RS12420	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
WK25_RS12425	COG0318	PFAM AMP-dependent synthetase and ligase
WK25_RS12430	COG4974	Belongs to the 'phage' integrase family
WK25_RS12440	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
WK25_RS12445	COG0802	atpase or kinase
WK25_RS12450	COG0860	N-Acetylmuramoyl-L-alanine amidase
WK25_RS12460	COG1741	Belongs to the pirin family
WK25_RS12470	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
WK25_RS12480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WK25_RS12490	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
WK25_RS12505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
WK25_RS12510	COG1522	sequence-specific DNA binding
WK25_RS12515	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
WK25_RS12525	COG3483	tryptophan 2,3-dioxygenase activity
WK25_RS12540	COG1012	belongs to the aldehyde dehydrogenase family
WK25_RS12555	COG0246	Mannitol dehydrogenase
WK25_RS12560	COG1070	Carbohydrate kinase
WK25_RS12565	COG2390	Transcriptional regulator
WK25_RS12570	COG3842	ATPase activity
WK25_RS12575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WK25_RS12585	COG4209	transmembrane transport
WK25_RS12595	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
WK25_RS12600	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WK25_RS12610	COG0735	belongs to the Fur family
WK25_RS12620	COG1121	(ABC) transporter
WK25_RS12625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
WK25_RS12630	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
WK25_RS12640	COG1070	Carbohydrate kinase
WK25_RS12645	COG2233	PERMEase
WK25_RS12655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
WK25_RS12675	COG4977	sequence-specific DNA binding
WK25_RS12695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WK25_RS12710	COG2027	D-alanyl-D-alanine carboxypeptidase
WK25_RS12725	COG0009	L-threonylcarbamoyladenylate synthase
WK25_RS12730	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
WK25_RS12735	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
WK25_RS12740	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
WK25_RS12750	COG0469	pyruvate kinase activity
WK25_RS12755	COG0126	phosphoglycerate kinase activity
WK25_RS12790	COG0429	hydrolase of the alpha beta-hydrolase fold
WK25_RS12800	COG4783	chaperone-mediated protein folding
WK25_RS12805	COG0315	cyclic pyranopterin monophosphate synthase activity
WK25_RS12820	COG4969	Belongs to the N-Me-Phe pilin family
WK25_RS12825	COG0861	Integral membrane protein TerC family
WK25_RS12830	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
WK25_RS12835	COG0045	succinate-CoA ligase (ADP-forming) activity
WK25_RS12845	COG2137	regulation of response to DNA damage stimulus
WK25_RS12850	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
WK25_RS12910	COG0583	DNA-binding transcription factor activity
WK25_RS12915	COG4977	sequence-specific DNA binding
WK25_RS12950	COG3813	Protein conserved in bacteria
WK25_RS12955	COG2186	Transcriptional regulator
WK25_RS12960	COG4948	Mandelate Racemase Muconate Lactonizing
WK25_RS12970	COG2863	cytochrome
WK25_RS12980	COG0513	Belongs to the DEAD box helicase family
WK25_RS13020	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
WK25_RS13025	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
WK25_RS13035	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
WK25_RS13045	COG1396	sequence-specific DNA binding
WK25_RS13050	COG2814	Major facilitator Superfamily
WK25_RS13055	COG0583	DNA-binding transcription factor activity
WK25_RS13060	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
WK25_RS13065	COG1702	phosphate starvation-inducible protein PhoH
WK25_RS13075	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
WK25_RS13080	COG4535	Mg2 and Co2 transporter CorC
WK25_RS13085	COG0815	Transfers the fatty acyl group on membrane lipoproteins
WK25_RS13095	COG0752	glycyl-tRNA synthetase alpha subunit
WK25_RS13100	COG0751	glycine-tRNA ligase activity
WK25_RS13105	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
WK25_RS13110	COG0204	Acyl-transferase
WK25_RS13130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
WK25_RS13135	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
WK25_RS13150	COG3178	'Phosphotransferase
WK25_RS13160	COG5265	(ABC) transporter
WK25_RS13175	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
WK25_RS13180	COG1024	Enoyl-CoA hydratase
WK25_RS13185	COG0183	Belongs to the thiolase family
WK25_RS13190	COG1024	Enoyl-CoA hydratase
WK25_RS13190	COG1250	3-hydroxyacyl-CoA dehydrogenase
WK25_RS13195	COG1960	acyl-CoA dehydrogenase activity
WK25_RS13210	COG0494	nUDIX hydrolase
WK25_RS13215	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
WK25_RS13230	COG0500	methyltransferase
WK25_RS13270	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
WK25_RS13280	COG0251	oxidation-reduction process
WK25_RS13285	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
WK25_RS13290	COG0837	glucose binding
WK25_RS13290	COG1737	Transcriptional regulator
WK25_RS13310	COG0477	Major facilitator Superfamily
WK25_RS13330	COG0235	Class ii aldolase
WK25_RS13335	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
WK25_RS13345	COG1620	l-lactate permease
WK25_RS13350	COG0501	Belongs to the peptidase M48B family
WK25_RS13370	COG1028	Short-chain dehydrogenase reductase Sdr
WK25_RS13375	COG0183	Belongs to the thiolase family
WK25_RS13395	COG0629	single-stranded DNA binding
WK25_RS13400	COG2814	Major facilitator Superfamily
WK25_RS13425	COG1280	lysine exporter protein (LysE YggA)
WK25_RS13445	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
WK25_RS13460	COG1137	ATPase activity
WK25_RS13465	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
WK25_RS13470	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
WK25_RS13495	COG1194	a g-specific adenine glycosylase
WK25_RS13510	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
WK25_RS13525	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
WK25_RS13545	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
WK25_RS13550	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
WK25_RS13555	COG0742	ribosomal rna small subunit methyltransferase
WK25_RS13565	COG0625	glutathione transferase activity
WK25_RS13570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
WK25_RS13575	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
WK25_RS13590	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
WK25_RS13605	COG1294	oxidase, subunit
WK25_RS13620	COG1263	PTS System
WK25_RS13620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
WK25_RS13620	COG2190	(PTS) system
WK25_RS13625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WK25_RS13625	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
WK25_RS13630	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WK25_RS13635	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
WK25_RS13640	COG2188	Transcriptional regulator
WK25_RS13645	COG0587	DNA-directed DNA polymerase activity
WK25_RS13660	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
WK25_RS13685	COG0840	transmembrane signaling receptor activity
WK25_RS13695	COG1999	signal sequence binding
WK25_RS13740	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
WK25_RS13755	COG2226	methyltransferase
WK25_RS13760	COG1040	competence protein
WK25_RS13765	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
WK25_RS13770	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
WK25_RS13790	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
WK25_RS13795	COG0588	phosphoglycerate mutase activity
WK25_RS13800	COG0793	Belongs to the peptidase S41A family
WK25_RS13805	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
WK25_RS13810	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
WK25_RS13815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
WK25_RS13825	COG0189	ligase activity
WK25_RS13835	COG0004	ammonium transporteR
WK25_RS13845	COG2960	long-chain fatty acid transporting porin activity
WK25_RS13870	COG4191	Histidine kinase
WK25_RS13875	COG1301	dicarboxylic acid transport
WK25_RS13880	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
WK25_RS13890	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WK25_RS13895	COG1960	acyl-CoA dehydrogenase activity
WK25_RS13900	COG1960	acyl-CoA dehydrogenase activity
WK25_RS13910	COG0583	DNA-binding transcription factor activity
WK25_RS13915	COG0405	Gamma-glutamyltransferase
WK25_RS13920	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
WK25_RS13930	COG4521	taurine ABC transporter
WK25_RS13940	COG1132	(ABC) transporter
WK25_RS13950	COG2368	4-hydroxyphenylacetate
WK25_RS13960	COG0321	lipoyl(octanoyl) transferase activity
WK25_RS13970	COG0583	DNA-binding transcription factor activity
WK25_RS13975	COG2921	Belongs to the UPF0250 family
WK25_RS13985	COG1686	Belongs to the peptidase S11 family
WK25_RS14015	COG1127	ABC transporter
WK25_RS14020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
WK25_RS14025	COG0737	Belongs to the 5'-nucleotidase family
WK25_RS14040	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
WK25_RS14040	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
WK25_RS14075	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
WK25_RS14095	COG1024	Enoyl-CoA hydratase
WK25_RS14125	COG0646	methionine synthase
WK25_RS14125	COG1410	methionine synthase
WK25_RS14135	COG0018	arginyl-trna synthetase
WK25_RS14145	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
WK25_RS14150	COG0300	oxidoreductase activity
WK25_RS14155	COG0747	negative chemotaxis
WK25_RS14160	COG0488	(ABC) transporter
WK25_RS14175	COG0288	reversible hydration of carbon dioxide
WK25_RS14180	COG0300	oxidoreductase activity
WK25_RS14185	COG3012	SEC-C Motif Domain Protein
WK25_RS14230	COG2199	diguanylate cyclase activity
WK25_RS14230	COG2200	EAL domain
WK25_RS14235	COG0025	NhaP-type Na H and K H
WK25_RS14245	COG0110	maltose O-acetyltransferase activity
WK25_RS14250	COG0625	glutathione transferase activity
WK25_RS14260	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
WK25_RS14270	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
WK25_RS14275	COG0583	DNA-binding transcription factor activity
WK25_RS14285	COG4774	siderophore transport
WK25_RS14290	COG0625	glutathione transferase activity
WK25_RS14295	COG0583	DNA-binding transcription factor activity
WK25_RS14300	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WK25_RS14305	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
WK25_RS14310	COG2080	2 iron, 2 sulfur cluster binding
WK25_RS14320	COG3511	phospholipase C
WK25_RS14335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WK25_RS14365	COG0596	Alpha beta hydrolase
WK25_RS14375	COG0583	DNA-binding transcription factor activity
WK25_RS14400	COG1609	Transcriptional regulator
WK25_RS14450	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
WK25_RS14465	COG0672	)-iron permease
WK25_RS14480	COG1012	belongs to the aldehyde dehydrogenase family
WK25_RS14490	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
WK25_RS14495	COG0174	glutamine synthetase
WK25_RS14510	COG3842	ATPase activity
WK25_RS14515	COG1176	ABC-type spermidine putrescine transport system, permease component I
WK25_RS14520	COG1177	transmembrane transport
WK25_RS14530	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WK25_RS14535	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
WK25_RS14565	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
WK25_RS14590	COG0583	DNA-binding transcription factor activity
WK25_RS14595	COG2233	PERMEase
WK25_RS14605	COG1256	bacterial-type flagellum assembly
WK25_RS14610	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
WK25_RS14620	COG1706	bacterial-type flagellum-dependent cell motility
WK25_RS14645	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
WK25_RS14650	COG1558	bacterial-type flagellum-dependent cell motility
WK25_RS14655	COG1815	bacterial-type flagellum-dependent cell motility
WK25_RS14675	COG0006	proline dipeptidase activity
WK25_RS14700	COG0741	lytic transglycosylase activity
WK25_RS14705	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
WK25_RS14715	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
WK25_RS14720	COG1984	allophanate hydrolase subunit 2
WK25_RS14765	COG4608	Belongs to the ABC transporter superfamily
WK25_RS14770	COG0444	Belongs to the ABC transporter superfamily
WK25_RS14775	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
WK25_RS14780	COG0601	transmembrane transport
WK25_RS14785	COG0747	negative chemotaxis
WK25_RS14800	COG0579	oxidoreductase
WK25_RS14805	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
WK25_RS14820	COG3568	Endonuclease Exonuclease Phosphatase
WK25_RS14835	COG2197	response regulator
WK25_RS14840	COG0531	amino acid
WK25_RS14855	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
WK25_RS14895	COG1157	protein secretion by the type III secretion system
WK25_RS14925	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
WK25_RS14935	COG0697	spore germination
WK25_RS14945	COG0667	Aldo Keto reductase
WK25_RS14970	COG1560	Kdo2-lipid A biosynthetic process
WK25_RS14975	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
WK25_RS14985	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
WK25_RS14990	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
WK25_RS14995	COG0523	cobalamin synthesis protein
WK25_RS15010	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
WK25_RS15015	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
WK25_RS15045	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
WK25_RS15050	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
WK25_RS15055	COG2814	Major facilitator Superfamily
WK25_RS15065	COG2207	Transcriptional regulator
WK25_RS15070	COG1064	alcohol dehydrogenase
WK25_RS15075	COG0708	Exodeoxyribonuclease III
WK25_RS15080	COG2326	polyphosphate kinase activity
WK25_RS15085	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WK25_RS15095	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
WK25_RS15100	COG1077	Cell shape determining protein MreB Mrl
WK25_RS15115	COG0768	penicillin binding
WK25_RS15120	COG0772	Belongs to the SEDS family
WK25_RS15135	COG0720	synthase
WK25_RS15140	COG0602	queuosine metabolic process
WK25_RS15145	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
WK25_RS15170	COG1475	DNA binding
WK25_RS15255	COG2856	Zn peptidase
WK25_RS15260	COG1396	sequence-specific DNA binding
WK25_RS15285	COG2204	response regulator
WK25_RS15290	COG5000	phosphorelay sensor kinase activity
WK25_RS15300	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
WK25_RS15300	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
WK25_RS15305	COG0501	Belongs to the peptidase M48B family
WK25_RS15315	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
WK25_RS15320	COG0242	peptide deformylase activity
WK25_RS15325	COG0758	DNA mediated transformation
WK25_RS15340	COG0583	DNA-binding transcription factor activity
WK25_RS15345	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
WK25_RS15380	COG1620	l-lactate permease
WK25_RS15400	COG2169	Transcriptional regulator
WK25_RS15400	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
WK25_RS15420	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
WK25_RS15430	COG2203	Gaf domain
WK25_RS15430	COG4251	negative regulation of phosphorylation
WK25_RS15430	COG5001	Diguanylate cyclase
WK25_RS15430	COG3706	GGDEF domain
WK25_RS15435	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
WK25_RS15815	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
WK25_RS15935	COG0531	amino acid
WK25_RS16290	COG0070	glutamate synthase
WK25_RS16290	COG0069	glutamate synthase activity
WK25_RS16290	COG0067	glutamate synthase
WK25_RS16415	COG4232	protein-disulfide reductase activity
WK25_RS17395	COG0673	inositol 2-dehydrogenase activity
WK25_RS17490	COG4302	ethanolamine ammonia-lyase activity
WK25_RS17575	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WK25_RS17575	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
WK25_RS17575	COG0506	proline dehydrogenase activity
WK25_RS17600	COG0318	PFAM AMP-dependent synthetase and ligase
WK25_RS17765	COG0642	Histidine kinase
WK25_RS17810	COG0523	cobalamin synthesis protein
WK25_RS18310	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
WK25_RS18340	COG0439	Biotin carboxylase
WK25_RS18375	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
WK25_RS18660	COG0418	dihydroorotase activity
WK25_RS18870	COG0247	lactate metabolic process
WK25_RS18905	COG1017	nitric oxide dioxygenase activity
WK25_RS18905	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
WK25_RS18960	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
WK25_RS18970	COG0497	DNA recombination
WK25_RS19035	COG0617	tRNA 3'-terminal CCA addition
WK25_RS19240	COG1529	Aldehyde oxidase and xanthine dehydrogenase
WK25_RS19495	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
WK25_RS19710	COG0488	(ABC) transporter
WK25_RS20505	COG0281	malic enzyme
WK25_RS20505	COG0280	phosphate acetyltransferase
WK25_RS20550	COG2814	Major facilitator Superfamily
WK25_RS20620	COG2823	Periplasmic or secreted lipoprotein
WK25_RS21285	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
WK25_RS21305	COG1960	acyl-CoA dehydrogenase activity
WK25_RS22020	COG0142	geranyltranstransferase activity
WK25_RS22230	COG0281	malic enzyme
WK25_RS22230	COG0280	phosphate acetyltransferase
WK25_RS22350	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
WK25_RS22675	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
WK25_RS22705	COG0783	Belongs to the Dps family
WK25_RS22865	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
WK25_RS23165	COG0477	Major facilitator Superfamily
WK25_RS23695	COG1653	transport
WK25_RS24290	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
WK25_RS24320	COG1322	Protein conserved in bacteria
WK25_RS24425	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
WK25_RS24455	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
WK25_RS24555	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
WK25_RS24620	COG3511	phospholipase C
WK25_RS24625	COG3511	phospholipase C
WK25_RS24855	COG2200	EAL domain
WK25_RS24940	COG1840	ABC-type Fe3 transport system, periplasmic component
WK25_RS25195	COG0477	Major facilitator Superfamily
WK25_RS25330	COG0505	Belongs to the CarA family
WK25_RS25340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
WK25_RS25385	COG0573	inorganic phosphate transmembrane transporter activity
WK25_RS25740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WK25_RS26280	COG0583	DNA-binding transcription factor activity
WK25_RS26355	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
WK25_RS26525	COG0557	exoribonuclease II activity
WK25_RS26725	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
WK25_RS26795	COG2718	Belongs to the UPF0229 family
WK25_RS26800	COG2719	SpoVR family
WK25_RS26880	COG3188	usher protein
WK25_RS27155	COG1804	L-carnitine dehydratase bile acid-inducible protein F
WK25_RS27340	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
WK25_RS27490	COG2982	Protein involved in outer membrane biogenesis
WK25_RS27495	COG2982	Protein involved in outer membrane biogenesis
WK25_RS27525	COG0626	cystathionine gamma-synthase activity
WK25_RS27835	COG2346	COG2346, Truncated hemoglobins
WK25_RS27870	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
WK25_RS27880	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
WK25_RS27900	COG0726	polysaccharide deacetylase
WK25_RS28910	COG1473	amidohydrolase
WK25_RS29490	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA