locus-tag	class	description
E2R23_RS00020	COG1396	sequence-specific DNA binding
E2R23_RS00045	COG1309	transcriptional regulator
E2R23_RS00070	COG0473	3-isopropylmalate dehydrogenase activity
E2R23_RS00075	COG0583	DNA-binding transcription factor activity
E2R23_RS00095	COG0625	glutathione transferase activity
E2R23_RS00120	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS00130	COG0671	phosphoesterase, PA-phosphatase related
E2R23_RS00190	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E2R23_RS00205	COG0583	DNA-binding transcription factor activity
E2R23_RS00210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E2R23_RS00215	COG0589	response to stress
E2R23_RS00265	COG1045	serine acetyltransferase
E2R23_RS00275	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS00280	COG0302	gtp cyclohydrolase
E2R23_RS00300	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E2R23_RS00305	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E2R23_RS00310	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E2R23_RS00315	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E2R23_RS00380	COG1595	DNA-templated transcription, initiation
E2R23_RS00385	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E2R23_RS00420	COG2916	Histone family protein nucleoid-structuring protein H-NS
E2R23_RS00435	COG0477	Major facilitator Superfamily
E2R23_RS00560	COG0432	Pfam Uncharacterised protein family UPF0047
E2R23_RS00600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E2R23_RS00630	COG5295	Hep Hag repeat protein
E2R23_RS00655	COG3121	Chaperone
E2R23_RS00660	COG3188	usher protein
E2R23_RS00675	COG2885	chlorophyll binding
E2R23_RS00820	COG3188	usher protein
E2R23_RS00855	COG2271	Major facilitator Superfamily
E2R23_RS00860	COG1929	Belongs to the glycerate kinase type-1 family
E2R23_RS00865	COG0469	pyruvate kinase activity
E2R23_RS00870	COG3835	regulator
E2R23_RS00885	COG0300	oxidoreductase activity
E2R23_RS00885	COG0318	PFAM AMP-dependent synthetase and ligase
E2R23_RS00885	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E2R23_RS00885	COG3321	synthase
E2R23_RS00885	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS00920	COG5001	Diguanylate cyclase
E2R23_RS00920	COG4251	negative regulation of phosphorylation
E2R23_RS00920	COG3706	GGDEF domain
E2R23_RS00920	COG2203	Gaf domain
E2R23_RS00970	COG1879	ABC-type sugar transport system periplasmic component
E2R23_RS00975	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2R23_RS01010	COG0513	Belongs to the DEAD box helicase family
E2R23_RS01025	COG1473	amidohydrolase
E2R23_RS01030	COG0583	DNA-binding transcription factor activity
E2R23_RS01080	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS01110	COG3537	Alpha-1,2-mannosidase
E2R23_RS01140	COG0367	asparagine synthase
E2R23_RS01180	COG2885	chlorophyll binding
E2R23_RS01295	COG0583	DNA-binding transcription factor activity
E2R23_RS01350	COG1984	allophanate hydrolase subunit 2
E2R23_RS01365	COG0511	ligase activity, forming carbon-carbon bonds
E2R23_RS01370	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E2R23_RS01430	COG0840	transmembrane signaling receptor activity
E2R23_RS01490	COG0535	radical SAM domain protein
E2R23_RS01495	COG0840	transmembrane signaling receptor activity
E2R23_RS01520	COG1285	pathogenesis
E2R23_RS01610	COG0346	lactoylglutathione lyase activity
E2R23_RS01620	COG1562	ergosterol biosynthetic process
E2R23_RS01625	COG0583	DNA-binding transcription factor activity
E2R23_RS01645	COG1294	oxidase, subunit
E2R23_RS01650	COG1271	oxidase subunit
E2R23_RS01655	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E2R23_RS01675	COG2860	membrane
E2R23_RS01680	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E2R23_RS01690	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E2R23_RS01700	COG4558	Periplasmic binding protein
E2R23_RS01705	COG3720	iron ion transport
E2R23_RS01735	COG3842	ATPase activity
E2R23_RS01740	COG1840	ABC-type Fe3 transport system, periplasmic component
E2R23_RS01755	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS01765	COG0698	ribose 5-phosphate isomerase
E2R23_RS01770	COG1129	ABC transporter
E2R23_RS01775	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2R23_RS01780	COG1879	ABC-type sugar transport system periplasmic component
E2R23_RS01785	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS01790	COG1063	alcohol dehydrogenase
E2R23_RS01795	COG2376	Dihydroxyacetone kinase
E2R23_RS01825	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS01850	COG2755	lipolytic protein G-D-S-L family
E2R23_RS01850	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E2R23_RS01865	COG0583	DNA-binding transcription factor activity
E2R23_RS01870	COG1473	amidohydrolase
E2R23_RS01890	COG1309	transcriptional regulator
E2R23_RS01895	COG1414	Transcriptional regulator
E2R23_RS01905	COG0183	Belongs to the thiolase family
E2R23_RS01920	COG0840	transmembrane signaling receptor activity
E2R23_RS01960	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E2R23_RS01970	COG1288	antiporter activity
E2R23_RS01975	COG1414	Transcriptional regulator
E2R23_RS02010	COG0709	Synthesizes selenophosphate from selenide and ATP
E2R23_RS02045	COG0583	DNA-binding transcription factor activity
E2R23_RS02050	COG0657	acetylesterase activity
E2R23_RS02055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2R23_RS02070	COG1301	dicarboxylic acid transport
E2R23_RS02115	COG0318	PFAM AMP-dependent synthetase and ligase
E2R23_RS02120	COG0019	diaminopimelate decarboxylase activity
E2R23_RS02130	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E2R23_RS02135	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E2R23_RS02135	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2R23_RS02135	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E2R23_RS02135	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS02135	COG3321	synthase
E2R23_RS02145	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E2R23_RS02200	COG2197	response regulator
E2R23_RS02220	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E2R23_RS02225	COG2011	ABC-type metal ion transport system permease component
E2R23_RS02255	COG2186	Transcriptional regulator
E2R23_RS02260	COG0247	lactate metabolic process
E2R23_RS02265	COG1139	Iron-sulfur cluster binding protein
E2R23_RS02270	COG1556	Lactate utilization protein
E2R23_RS02275	COG1620	l-lactate permease
E2R23_RS02285	COG2259	Doxx family
E2R23_RS02310	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E2R23_RS02320	COG0531	amino acid
E2R23_RS02330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2R23_RS02345	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2R23_RS02370	COG3547	Transposase (IS116 IS110 IS902 family)
E2R23_RS02385	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E2R23_RS02390	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E2R23_RS02395	COG2271	Major facilitator Superfamily
E2R23_RS02420	COG1176	ABC-type spermidine putrescine transport system, permease component I
E2R23_RS02435	COG1012	belongs to the aldehyde dehydrogenase family
E2R23_RS02490	COG0789	Transcriptional regulator
E2R23_RS02505	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E2R23_RS02510	COG0667	Aldo Keto reductase
E2R23_RS02515	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS02530	COG0556	nucleotide-excision repair
E2R23_RS02540	COG4633	Protein conserved in bacteria
E2R23_RS02545	COG0672	)-iron permease
E2R23_RS02555	COG3193	protein, possibly involved in utilization of glycolate and propanediol
E2R23_RS02605	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E2R23_RS02640	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E2R23_RS02700	COG2801	Transposase and inactivated derivatives
E2R23_RS02785	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2R23_RS02835	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E2R23_RS02885	COG0583	DNA-binding transcription factor activity
E2R23_RS02890	COG1741	Belongs to the pirin family
E2R23_RS02930	COG2814	Major facilitator Superfamily
E2R23_RS02940	COG0583	DNA-binding transcription factor activity
E2R23_RS02945	COG1335	isochorismatase
E2R23_RS02955	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E2R23_RS03000	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E2R23_RS03010	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2R23_RS03045	COG1796	DNA polymerase
E2R23_RS03045	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E2R23_RS03090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2R23_RS03095	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2R23_RS03105	COG1177	transmembrane transport
E2R23_RS03110	COG1176	ABC-type spermidine putrescine transport system, permease component I
E2R23_RS03115	COG3842	ATPase activity
E2R23_RS03130	COG0174	glutamine synthetase
E2R23_RS03135	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E2R23_RS03150	COG1917	Cupin 2, conserved barrel domain protein
E2R23_RS03150	COG1396	sequence-specific DNA binding
E2R23_RS03155	COG1012	belongs to the aldehyde dehydrogenase family
E2R23_RS03160	COG0010	Belongs to the arginase family
E2R23_RS03170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E2R23_RS03205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E2R23_RS03225	COG0318	PFAM AMP-dependent synthetase and ligase
E2R23_RS03260	COG3634	alkyl hydroperoxide reductase activity
E2R23_RS03285	COG0778	Nitroreductase
E2R23_RS03295	COG2308	Evidence 4 Homologs of previously reported genes of
E2R23_RS03325	COG1305	Transglutaminase-like
E2R23_RS03330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2R23_RS03350	COG4977	sequence-specific DNA binding
E2R23_RS03360	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E2R23_RS03365	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E2R23_RS03365	COG0028	Belongs to the TPP enzyme family
E2R23_RS03530	COG2814	Major facilitator Superfamily
E2R23_RS03555	COG1566	PFAM secretion protein HlyD family protein
E2R23_RS03565	COG1621	beta-fructofuranosidase activity
E2R23_RS03595	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E2R23_RS03610	COG0446	pyridine nucleotide-disulphide oxidoreductase
E2R23_RS03610	COG1902	pentaerythritol trinitrate reductase activity
E2R23_RS03615	COG0247	lactate metabolic process
E2R23_RS03615	COG2181	nitrate reductase activity
E2R23_RS03620	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E2R23_RS03640	COG2113	Glycine betaine
E2R23_RS03655	COG0583	DNA-binding transcription factor activity
E2R23_RS03660	COG3119	arylsulfatase activity
E2R23_RS03700	COG3246	L-lysine catabolic process to acetate
E2R23_RS03705	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2R23_RS03715	COG0657	acetylesterase activity
E2R23_RS03815	COG1021	2,3-dihydroxybenzoate-AMP ligase
E2R23_RS03825	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E2R23_RS03825	COG2226	methyltransferase
E2R23_RS03825	COG3433	isochorismatase activity
E2R23_RS03840	COG1132	(ABC) transporter
E2R23_RS03840	COG2375	cellular response to nickel ion
E2R23_RS03845	COG1132	(ABC) transporter
E2R23_RS03885	COG3284	Transcriptional regulator
E2R23_RS03920	COG2252	PERMEase
E2R23_RS03965	COG1012	belongs to the aldehyde dehydrogenase family
E2R23_RS03975	COG0028	Belongs to the TPP enzyme family
E2R23_RS03975	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E2R23_RS04010	COG0330	HflC and HflK could
E2R23_RS04025	COG1960	acyl-CoA dehydrogenase activity
E2R23_RS04030	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E2R23_RS04045	COG1024	Enoyl-CoA hydratase
E2R23_RS04050	COG1024	Enoyl-CoA hydratase
E2R23_RS04060	COG1538	Outer membrane efflux protein
E2R23_RS04070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2R23_RS04100	COG2066	Belongs to the glutaminase family
E2R23_RS04110	COG0745	RESPONSE REGULATOR receiver
E2R23_RS04115	COG2205	protein histidine kinase activity
E2R23_RS04205	COG0642	Histidine kinase
E2R23_RS04375	COG3291	Pkd domain containing protein
E2R23_RS04395	COG3214	Protein conserved in bacteria
E2R23_RS04405	COG0477	Major facilitator Superfamily
E2R23_RS04415	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E2R23_RS04435	COG1845	cytochrome c oxidase, subunit III
E2R23_RS04495	COG2207	Transcriptional regulator
E2R23_RS04550	COG2205	protein histidine kinase activity
E2R23_RS04555	COG0745	RESPONSE REGULATOR receiver
E2R23_RS04570	COG1846	Transcriptional regulator
E2R23_RS04585	COG1012	belongs to the aldehyde dehydrogenase family
E2R23_RS04590	COG3384	dioxygenase
E2R23_RS04600	COG3971	2-oxopent-4-enoate hydratase activity
E2R23_RS04610	COG2207	Transcriptional regulator
E2R23_RS04625	COG3842	ATPase activity
E2R23_RS04630	COG4208	sulfate ABC transporter
E2R23_RS04645	COG0642	Histidine kinase
E2R23_RS04655	COG3217	Mosc domain protein beta barrel domain protein
E2R23_RS04655	COG0633	Ferredoxin
E2R23_RS04665	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS04690	COG1024	Enoyl-CoA hydratase
E2R23_RS04720	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E2R23_RS04725	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
E2R23_RS04760	COG1309	transcriptional regulator
E2R23_RS04780	COG1902	pentaerythritol trinitrate reductase activity
E2R23_RS04795	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E2R23_RS04805	COG0628	permease
E2R23_RS04815	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS04855	COG0318	PFAM AMP-dependent synthetase and ligase
E2R23_RS04875	COG1215	transferase activity, transferring glycosyl groups
E2R23_RS04975	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS05020	COG0583	DNA-binding transcription factor activity
E2R23_RS05045	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS05060	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E2R23_RS05065	COG2508	Transcriptional regulator
E2R23_RS05070	COG0402	S-adenosylhomocysteine deaminase activity
E2R23_RS05100	COG0038	chloride channel
E2R23_RS05130	COG2197	response regulator
E2R23_RS05205	COG1024	Enoyl-CoA hydratase
E2R23_RS05210	COG1012	belongs to the aldehyde dehydrogenase family
E2R23_RS05215	COG3320	Male sterility
E2R23_RS05215	COG1022	Amp-dependent synthetase and ligase
E2R23_RS05220	COG2814	Major facilitator Superfamily
E2R23_RS05235	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS05260	COG1129	ABC transporter
E2R23_RS05265	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2R23_RS05275	COG2721	sulfolactate sulfo-lyase activity
E2R23_RS05290	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS05300	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS05335	COG2916	Histone family protein nucleoid-structuring protein H-NS
E2R23_RS05390	COG1272	protein, Hemolysin III
E2R23_RS05410	COG1522	sequence-specific DNA binding
E2R23_RS05425	COG1448	Aminotransferase
E2R23_RS05485	COG4191	Histidine kinase
E2R23_RS05485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2R23_RS05490	COG2201	protein-glutamate methylesterase activity
E2R23_RS05500	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E2R23_RS05505	COG2373	Large extracellular alpha-helical protein
E2R23_RS05535	COG0495	leucyl-tRNA aminoacylation
E2R23_RS05555	COG2175	clavaminate synthase activity
E2R23_RS05560	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E2R23_RS05580	COG3291	Pkd domain containing protein
E2R23_RS05595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2R23_RS05660	COG0589	response to stress
E2R23_RS05700	COG4221	oxidoreductase activity
E2R23_RS05720	COG1113	amino acid transport
E2R23_RS05735	COG2916	Histone family protein nucleoid-structuring protein H-NS
E2R23_RS05790	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E2R23_RS05835	COG0583	DNA-binding transcription factor activity
E2R23_RS05845	COG0583	DNA-binding transcription factor activity
E2R23_RS05885	COG1012	belongs to the aldehyde dehydrogenase family
E2R23_RS05890	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E2R23_RS05895	COG0531	amino acid
E2R23_RS05910	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS05930	COG1902	pentaerythritol trinitrate reductase activity
E2R23_RS05945	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS05950	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E2R23_RS05965	COG0517	IMP dehydrogenase activity
E2R23_RS05965	COG0516	GMP reductase activity
E2R23_RS05970	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E2R23_RS05995	COG2197	response regulator
E2R23_RS06000	COG1285	pathogenesis
E2R23_RS06010	COG1408	metallophosphoesterase
E2R23_RS06025	COG1414	Transcriptional regulator
E2R23_RS06030	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS06040	COG2146	nitrite reductase [NAD(P)H] activity
E2R23_RS06070	COG1414	Transcriptional regulator
E2R23_RS06075	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS06080	COG0028	Belongs to the TPP enzyme family
E2R23_RS06090	COG1012	belongs to the aldehyde dehydrogenase family
E2R23_RS06105	COG0477	Major facilitator Superfamily
E2R23_RS06135	COG0154	amidase activity
E2R23_RS06145	COG1522	sequence-specific DNA binding
E2R23_RS06225	COG0596	Alpha beta hydrolase
E2R23_RS06255	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2R23_RS06285	COG0840	transmembrane signaling receptor activity
E2R23_RS06305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E2R23_RS06310	COG0596	Alpha beta hydrolase
E2R23_RS06360	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS06400	COG0583	DNA-binding transcription factor activity
E2R23_RS06425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2R23_RS06430	COG0601	transmembrane transport
E2R23_RS06440	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
E2R23_RS06475	COG3209	COG3209 Rhs family protein
E2R23_RS06520	COG2140	Oxalate decarboxylase
E2R23_RS06525	COG1914	H( )-stimulated, divalent metal cation uptake system
E2R23_RS06535	COG4682	membrane
E2R23_RS06540	COG3781	membrane
E2R23_RS06545	COG0243	molybdopterin cofactor binding
E2R23_RS06550	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2R23_RS06575	COG1404	Belongs to the peptidase S8 family
E2R23_RS06610	COG2259	Doxx family
E2R23_RS06635	COG4160	amino acid transport
E2R23_RS06640	COG4598	ABC transporter
E2R23_RS06645	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E2R23_RS06705	COG3275	phosphorelay sensor kinase activity
E2R23_RS06735	COG0500	methyltransferase
E2R23_RS06740	COG2207	Transcriptional regulator
E2R23_RS06760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E2R23_RS06765	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E2R23_RS06770	COG1024	Enoyl-CoA hydratase
E2R23_RS06775	COG1024	Enoyl-CoA hydratase
E2R23_RS06780	COG3425	synthase
E2R23_RS06800	COG2070	2-Nitropropane dioxygenase
E2R23_RS06800	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E2R23_RS06805	COG0569	domain protein
E2R23_RS06805	COG0475	glutathione-regulated potassium exporter activity
E2R23_RS06820	COG4221	oxidoreductase activity
E2R23_RS06820	COG3321	synthase
E2R23_RS06820	COG0300	oxidoreductase activity
E2R23_RS06820	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E2R23_RS06870	COG0583	DNA-binding transcription factor activity
E2R23_RS06880	COG0387	Pfam Sodium calcium exchanger
E2R23_RS06905	COG0179	Fumarylacetoacetate (FAA) hydrolase
E2R23_RS06935	COG2353	YceI-like domain
E2R23_RS06950	COG1595	DNA-templated transcription, initiation
E2R23_RS06955	COG3712	iron ion homeostasis
E2R23_RS06960	COG4774	siderophore transport
E2R23_RS06965	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2R23_RS06970	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2R23_RS06975	COG1129	ABC transporter
E2R23_RS07010	COG1960	acyl-CoA dehydrogenase activity
E2R23_RS07020	COG2271	Major facilitator Superfamily
E2R23_RS07100	COG3657	addiction module killer protein
E2R23_RS07105	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E2R23_RS07110	COG4695	Portal protein
E2R23_RS07260	COG0686	Belongs to the AlaDH PNT family
E2R23_RS07300	COG0443	Heat shock 70 kDa protein
E2R23_RS07305	COG0443	Heat shock 70 kDa protein
E2R23_RS07395	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E2R23_RS07455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2R23_RS07460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2R23_RS07475	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E2R23_RS07490	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E2R23_RS07495	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E2R23_RS07495	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E2R23_RS07545	COG0446	pyridine nucleotide-disulphide oxidoreductase
E2R23_RS07545	COG1902	pentaerythritol trinitrate reductase activity
E2R23_RS07550	COG1695	Transcriptional regulator
E2R23_RS07605	COG3260	NADH ubiquinone oxidoreductase 20
E2R23_RS07610	COG0649	NAD binding
E2R23_RS07615	COG0651	ATP synthesis coupled electron transport
E2R23_RS07625	COG0650	Formate hydrogenlyase subunit 4
E2R23_RS07630	COG0651	ATP synthesis coupled electron transport
E2R23_RS07670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2R23_RS07675	COG2181	nitrate reductase activity
E2R23_RS07680	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E2R23_RS07685	COG1140	nitrate reductase beta subunit
E2R23_RS07690	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E2R23_RS07700	COG3851	Histidine kinase
E2R23_RS07720	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E2R23_RS07745	COG2175	clavaminate synthase activity
E2R23_RS07765	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E2R23_RS07790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E2R23_RS07795	COG0339	signal peptide processing
E2R23_RS07815	COG0475	glutathione-regulated potassium exporter activity
E2R23_RS07880	COG0318	PFAM AMP-dependent synthetase and ligase
E2R23_RS07885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2R23_RS07945	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E2R23_RS07965	COG0540	Belongs to the ATCase OTCase family
E2R23_RS08040	COG0477	Major facilitator Superfamily
E2R23_RS08045	COG0352	thiamine-phosphate diphosphorylase activity
E2R23_RS08065	COG0840	transmembrane signaling receptor activity
E2R23_RS08090	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS08095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E2R23_RS08095	COG4651	solute:proton antiporter activity
E2R23_RS08150	COG1349	DNA-binding transcription factor activity
E2R23_RS08155	COG2223	nitrite transmembrane transporter activity
E2R23_RS08200	COG1063	alcohol dehydrogenase
E2R23_RS08205	COG3842	ATPase activity
E2R23_RS08215	COG1070	Carbohydrate kinase
E2R23_RS08240	COG0243	molybdopterin cofactor binding
E2R23_RS08245	COG2146	nitrite reductase [NAD(P)H] activity
E2R23_RS08250	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2R23_RS08270	COG3707	response regulator
E2R23_RS08275	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2R23_RS08275	COG1116	anion transmembrane transporter activity
E2R23_RS08285	COG0302	gtp cyclohydrolase
E2R23_RS08325	COG0477	Major facilitator Superfamily
E2R23_RS08330	COG0583	DNA-binding transcription factor activity
E2R23_RS08345	COG0583	DNA-binding transcription factor activity
E2R23_RS08350	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS08380	COG2130	NADP-dependent
E2R23_RS08385	COG1979	alcohol dehydrogenase
E2R23_RS08445	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E2R23_RS08485	COG0318	PFAM AMP-dependent synthetase and ligase
E2R23_RS08515	COG1739	Uncharacterized protein family UPF0029
E2R23_RS08585	COG2274	protein secretion by the type I secretion system
E2R23_RS08640	COG0531	amino acid
E2R23_RS08660	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E2R23_RS08665	COG4122	O-methyltransferase activity
E2R23_RS08675	COG2203	Gaf domain
E2R23_RS08675	COG3706	GGDEF domain
E2R23_RS08675	COG5001	Diguanylate cyclase
E2R23_RS08675	COG4251	negative regulation of phosphorylation
E2R23_RS08695	COG0583	DNA-binding transcription factor activity
E2R23_RS08700	COG3485	protocatechuate 3,4-dioxygenase
E2R23_RS08705	COG3485	protocatechuate 3,4-dioxygenase
E2R23_RS08720	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2R23_RS08725	COG0601	transmembrane transport
E2R23_RS08730	COG0747	negative chemotaxis
E2R23_RS08735	COG4172	Belongs to the ABC transporter superfamily
E2R23_RS08740	COG1446	asparaginase
E2R23_RS08750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E2R23_RS08795	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E2R23_RS08805	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E2R23_RS08820	COG0277	FAD linked oxidase domain protein
E2R23_RS08880	COG2188	Transcriptional regulator
E2R23_RS08885	COG2814	Major facilitator Superfamily
E2R23_RS08900	COG1858	cytochrome C peroxidase
E2R23_RS08905	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E2R23_RS08930	COG0456	acetyltransferase
E2R23_RS08940	COG2391	methyltransferase activity
E2R23_RS08945	COG0640	Transcriptional regulator
E2R23_RS08955	COG3038	cytochrome b561
E2R23_RS08960	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E2R23_RS08965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E2R23_RS08975	COG1045	serine acetyltransferase
E2R23_RS08990	COG1505	serine-type exopeptidase activity
E2R23_RS09005	COG1566	PFAM secretion protein HlyD family protein
E2R23_RS09030	COG2814	Major facilitator Superfamily
E2R23_RS09090	COG0477	Major facilitator Superfamily
E2R23_RS09100	COG0784	Response regulator, receiver
E2R23_RS09105	COG4251	negative regulation of phosphorylation
E2R23_RS09120	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E2R23_RS09150	COG1278	Cold shock
E2R23_RS09190	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E2R23_RS09190	COG0446	pyridine nucleotide-disulphide oxidoreductase
E2R23_RS09210	COG1760	l-serine dehydratase
E2R23_RS09250	COG1294	oxidase, subunit
E2R23_RS09255	COG1271	oxidase subunit
E2R23_RS09265	COG1285	pathogenesis
E2R23_RS09295	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2R23_RS09310	COG4644	lycopene metabolic process
E2R23_RS09345	COG1450	Type ii and iii secretion system protein
E2R23_RS09350	COG2207	Transcriptional regulator
E2R23_RS09395	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E2R23_RS09400	COG4789	Type iii secretion
E2R23_RS09480	COG2186	Transcriptional regulator
E2R23_RS09485	COG2084	Dehydrogenase
E2R23_RS09490	COG3395	kinase activity
E2R23_RS09495	COG0235	Class ii aldolase
E2R23_RS09500	COG2271	Major facilitator Superfamily
E2R23_RS09505	COG3622	Belongs to the hyi family
E2R23_RS09510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2R23_RS09560	COG4175	Glycine betaine
E2R23_RS09600	COG0640	Transcriptional regulator
E2R23_RS09615	COG0798	PFAM Bile acid sodium symporter
E2R23_RS09645	COG5295	Hep Hag repeat protein
E2R23_RS09645	COG5295	Hep Hag repeat protein
E2R23_RS09685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E2R23_RS09690	COG1960	acyl-CoA dehydrogenase activity
E2R23_RS09735	COG4638	Rieske (2fe-2S)
E2R23_RS09775	COG2271	Major facilitator Superfamily
E2R23_RS09820	COG1477	protein flavinylation
E2R23_RS09825	COG1012	belongs to the aldehyde dehydrogenase family
E2R23_RS09830	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2R23_RS09845	COG0583	DNA-binding transcription factor activity
E2R23_RS09860	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2R23_RS09875	COG3547	Transposase (IS116 IS110 IS902 family)
E2R23_RS09890	COG1349	DNA-binding transcription factor activity
E2R23_RS09900	COG2271	Major facilitator Superfamily
E2R23_RS09910	COG0246	Mannitol dehydrogenase
E2R23_RS09920	COG4948	Mandelate Racemase Muconate Lactonizing
E2R23_RS09925	COG1063	alcohol dehydrogenase
E2R23_RS09965	COG5441	Belongs to the UPF0261 family
E2R23_RS09970	COG5564	TIM-barrel signal transduction protein
E2R23_RS10005	COG3023	N-Acetylmuramoyl-L-alanine amidase
E2R23_RS10145	COG0302	gtp cyclohydrolase
E2R23_RS10225	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E2R23_RS10240	COG2916	Histone family protein nucleoid-structuring protein H-NS
E2R23_RS10275	COG4790	Type iii secretion
E2R23_RS10425	COG0477	Major facilitator Superfamily
E2R23_RS10455	COG1280	lysine exporter protein (LysE YggA)
E2R23_RS10460	COG1522	sequence-specific DNA binding
E2R23_RS10470	COG0306	phosphate transporter
E2R23_RS10495	COG0318	PFAM AMP-dependent synthetase and ligase
E2R23_RS10525	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2R23_RS10535	COG4521	taurine ABC transporter
E2R23_RS10545	COG2175	clavaminate synthase activity
E2R23_RS10555	COG2194	sulfuric ester hydrolase activity
E2R23_RS10560	COG1215	transferase activity, transferring glycosyl groups
E2R23_RS10580	COG0457	Tetratricopeptide repeat
E2R23_RS10585	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
E2R23_RS10590	COG1215	transferase activity, transferring glycosyl groups
E2R23_RS10605	COG3550	peptidyl-serine autophosphorylation
E2R23_RS10735	COG1450	Type ii and iii secretion system protein
E2R23_RS10785	COG2207	Transcriptional regulator
E2R23_RS10820	COG4794	Type iii secretion
E2R23_RS10825	COG4790	Type iii secretion
E2R23_RS10840	COG4789	Type iii secretion
E2R23_RS10845	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E2R23_RS10920	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E2R23_RS10930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E2R23_RS10970	COG0028	Belongs to the TPP enzyme family
E2R23_RS10975	COG0427	acetyl-CoA hydrolase
E2R23_RS10980	COG2030	dehydratase
E2R23_RS10990	COG0583	DNA-binding transcription factor activity
E2R23_RS11010	COG2814	Major facilitator Superfamily
E2R23_RS11020	COG4191	Histidine kinase
E2R23_RS11060	COG3621	Patatin-like phospholipase
E2R23_RS11100	COG1472	Belongs to the glycosyl hydrolase 3 family
E2R23_RS11110	COG0154	amidase activity
E2R23_RS11130	COG3276	selenocysteine insertion sequence binding
E2R23_RS11135	COG1921	L-seryl-tRNASec selenium transferase activity
E2R23_RS11145	COG2864	formate dehydrogenase
E2R23_RS11150	COG0437	4 iron, 4 sulfur cluster binding
E2R23_RS11155	COG3383	formate dehydrogenase (NAD+) activity
E2R23_RS11155	COG0243	molybdopterin cofactor binding
E2R23_RS11160	COG0243	molybdopterin cofactor binding
E2R23_RS11160	COG3383	formate dehydrogenase (NAD+) activity
E2R23_RS11180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2R23_RS11190	COG1126	abc transporter atp-binding protein
E2R23_RS11195	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2R23_RS11200	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2R23_RS11210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2R23_RS11235	COG3608	succinylglutamate desuccinylase aspartoacylase
E2R23_RS11255	COG1295	ribonuclease BN
E2R23_RS11260	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS11290	COG2755	lipolytic protein G-D-S-L family
E2R23_RS11290	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E2R23_RS11300	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E2R23_RS11315	COG0438	transferase activity, transferring glycosyl groups
E2R23_RS11335	COG2755	lipolytic protein G-D-S-L family
E2R23_RS11335	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E2R23_RS11340	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E2R23_RS11345	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2R23_RS11385	COG0285	dihydrofolate synthase activity
E2R23_RS11390	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E2R23_RS11395	COG0159	tryptophan synthase activity
E2R23_RS11405	COG0133	tryptophan synthase activity
E2R23_RS11410	COG0135	phosphoribosylanthranilate isomerase activity
E2R23_RS11465	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2R23_RS11490	COG1522	sequence-specific DNA binding
E2R23_RS11520	COG0372	Belongs to the citrate synthase family
E2R23_RS11525	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E2R23_RS11530	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E2R23_RS11535	COG1053	succinate dehydrogenase
E2R23_RS11545	COG2009	succinate dehydrogenase
E2R23_RS11555	COG2188	Transcriptional regulator
E2R23_RS11580	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E2R23_RS11585	COG3064	Membrane
E2R23_RS11585	COG3210	domain, Protein
E2R23_RS11585	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
E2R23_RS11590	COG2831	hemolysin activation secretion protein
E2R23_RS11655	COG1177	transmembrane transport
E2R23_RS11660	COG1176	ABC-type spermidine putrescine transport system, permease component I
E2R23_RS11670	COG3842	ATPase activity
E2R23_RS11685	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E2R23_RS11690	COG4774	siderophore transport
E2R23_RS11700	COG3038	cytochrome b561
E2R23_RS11745	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E2R23_RS11750	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E2R23_RS11775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E2R23_RS11800	COG2081	HI0933 family
E2R23_RS11825	COG0142	geranyltranstransferase activity
E2R23_RS11845	COG0412	Dienelactone hydrolase
E2R23_RS11865	COG1252	NADH dehydrogenase
E2R23_RS11875	COG1611	Belongs to the LOG family
E2R23_RS11895	COG1683	Conserved Protein
E2R23_RS11935	COG4695	Portal protein
E2R23_RS11950	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E2R23_RS11975	COG1846	Transcriptional regulator
E2R23_RS11980	COG1764	response to oxidative stress
E2R23_RS12005	COG0725	ABC transporter, periplasmic molybdate-binding protein
E2R23_RS12010	COG4149	molybdate abc transporter
E2R23_RS12045	COG0583	DNA-binding transcription factor activity
E2R23_RS12060	COG1253	flavin adenine dinucleotide binding
E2R23_RS12065	COG0352	thiamine-phosphate diphosphorylase activity
E2R23_RS12070	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E2R23_RS12090	COG1304	FMN binding
E2R23_RS12155	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E2R23_RS12175	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E2R23_RS12215	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E2R23_RS12220	COG5654	RES domain protein
E2R23_RS12225	COG5642	Protein of unknown function (DUF2384)
E2R23_RS12250	COG0438	transferase activity, transferring glycosyl groups
E2R23_RS12255	COG0438	transferase activity, transferring glycosyl groups
E2R23_RS12275	COG3206	protein involved in exopolysaccharide biosynthesis
E2R23_RS12275	COG0489	protein tyrosine kinase activity
E2R23_RS12295	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E2R23_RS12325	COG0247	lactate metabolic process
E2R23_RS12330	COG1592	Rubrerythrin
E2R23_RS12340	COG3023	N-Acetylmuramoyl-L-alanine amidase
E2R23_RS12355	COG4941	Belongs to the sigma-70 factor family
E2R23_RS12365	COG3795	YCII-related domain
E2R23_RS12370	COG3795	YCII-related domain
E2R23_RS12405	COG0628	permease
E2R23_RS12440	COG2130	NADP-dependent
E2R23_RS12465	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS12490	COG0583	DNA-binding transcription factor activity
E2R23_RS12520	COG2837	iron assimilation
E2R23_RS12530	COG5265	(ABC) transporter
E2R23_RS12540	COG4977	sequence-specific DNA binding
E2R23_RS12580	COG0038	chloride channel
E2R23_RS12620	COG0840	transmembrane signaling receptor activity
E2R23_RS12625	COG0642	Histidine kinase
E2R23_RS12640	COG1012	belongs to the aldehyde dehydrogenase family
E2R23_RS12650	COG0025	NhaP-type Na H and K H
E2R23_RS12655	COG2733	membrane
E2R23_RS12675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2R23_RS12690	COG2146	nitrite reductase [NAD(P)H] activity
E2R23_RS12695	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E2R23_RS12700	COG4638	Rieske (2fe-2S)
E2R23_RS12730	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E2R23_RS12755	COG1902	pentaerythritol trinitrate reductase activity
E2R23_RS12755	COG0446	pyridine nucleotide-disulphide oxidoreductase
E2R23_RS12775	COG0583	DNA-binding transcription factor activity
E2R23_RS12780	COG4638	Rieske (2fe-2S)
E2R23_RS12785	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E2R23_RS12790	COG0543	2 iron, 2 sulfur cluster binding
E2R23_RS12790	COG0633	Ferredoxin
E2R23_RS12795	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS12815	COG1335	isochorismatase
E2R23_RS12855	COG0833	amino acid
E2R23_RS12885	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E2R23_RS12895	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS12905	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E2R23_RS12940	COG1611	Belongs to the LOG family
E2R23_RS12980	COG0840	transmembrane signaling receptor activity
E2R23_RS13010	COG1136	(ABC) transporter
E2R23_RS13025	COG0589	response to stress
E2R23_RS13045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2R23_RS13055	COG0842	Transport permease protein
E2R23_RS13060	COG4191	Histidine kinase
E2R23_RS13060	COG0784	Response regulator, receiver
E2R23_RS13070	COG0840	transmembrane signaling receptor activity
E2R23_RS13100	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E2R23_RS13105	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E2R23_RS13105	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E2R23_RS13115	COG0356	it plays a direct role in the translocation of protons across the membrane
E2R23_RS13130	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E2R23_RS13135	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E2R23_RS13145	COG3243	poly(R)-hydroxyalkanoic acid synthase
E2R23_RS13150	COG0280	phosphate acetyltransferase
E2R23_RS13155	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E2R23_RS13180	COG2823	Periplasmic or secreted lipoprotein
E2R23_RS13190	COG0295	cytidine deaminase activity
E2R23_RS13225	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E2R23_RS13230	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E2R23_RS13245	COG0625	glutathione transferase activity
E2R23_RS13280	COG0596	Alpha beta hydrolase
E2R23_RS13380	COG1230	cation diffusion facilitator family transporter
E2R23_RS13430	COG1573	uracil-dna glycosylase
E2R23_RS13435	COG2936	dipeptidyl-peptidase activity
E2R23_RS13445	COG1404	Belongs to the peptidase S8 family
E2R23_RS13515	COG0672	)-iron permease
E2R23_RS13530	COG0504	CTP synthase activity
E2R23_RS13605	COG1215	transferase activity, transferring glycosyl groups
E2R23_RS13640	COG0583	DNA-binding transcription factor activity
E2R23_RS13645	COG1253	flavin adenine dinucleotide binding
E2R23_RS13700	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E2R23_RS13720	COG1960	acyl-CoA dehydrogenase activity
E2R23_RS13730	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS13735	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E2R23_RS13740	COG1960	acyl-CoA dehydrogenase activity
E2R23_RS13755	COG3246	L-lysine catabolic process to acetate
E2R23_RS13765	COG1022	Amp-dependent synthetase and ligase
E2R23_RS13825	COG0494	nUDIX hydrolase
E2R23_RS13875	COG3209	COG3209 Rhs family protein
E2R23_RS13920	COG1301	dicarboxylic acid transport
E2R23_RS13925	COG0251	oxidation-reduction process
E2R23_RS13930	COG0252	asparaginase activity
E2R23_RS13990	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS13995	COG1129	ABC transporter
E2R23_RS14010	COG4948	Mandelate Racemase Muconate Lactonizing
E2R23_RS14015	COG2186	Transcriptional regulator
E2R23_RS14020	COG3386	PFAM SMP-30 Gluconolaconase
E2R23_RS14035	COG3012	SEC-C Motif Domain Protein
E2R23_RS14045	COG3436	PFAM IS66 Orf2 family protein
E2R23_RS14070	COG0395	ABC-type sugar transport system, permease component
E2R23_RS14075	COG1175	transmembrane transport
E2R23_RS14080	COG1653	transport
E2R23_RS14085	COG3842	ATPase activity
E2R23_RS14100	COG1609	Transcriptional regulator
E2R23_RS14260	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS14275	COG3048	D-serine ammonia-lyase activity
E2R23_RS14280	COG0583	DNA-binding transcription factor activity
E2R23_RS14305	COG0477	Major facilitator Superfamily
E2R23_RS14310	COG1104	cysteine desulfurase activity
E2R23_RS14325	COG0477	Major facilitator Superfamily
E2R23_RS14335	COG0583	DNA-binding transcription factor activity
E2R23_RS14345	COG0179	Fumarylacetoacetate (FAA) hydrolase
E2R23_RS14390	COG2916	Histone family protein nucleoid-structuring protein H-NS
E2R23_RS14410	COG2610	gluconate transmembrane transporter activity
E2R23_RS14460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2R23_RS14465	COG0601	transmembrane transport
E2R23_RS14490	COG3104	oligopeptide transport
E2R23_RS14525	COG2079	MmgE PrpD family protein
E2R23_RS14530	COG2301	Belongs to the HpcH HpaI aldolase family
E2R23_RS14535	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2R23_RS14545	COG1335	isochorismatase
E2R23_RS14550	COG0477	Major facilitator Superfamily
E2R23_RS14560	COG2271	Major facilitator Superfamily
E2R23_RS14570	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2R23_RS14620	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2R23_RS14650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E2R23_RS14670	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E2R23_RS14690	COG2879	small protein
E2R23_RS14695	COG1966	Carbon starvation protein
E2R23_RS14755	COG0463	Glycosyl transferase, family 2
E2R23_RS14805	COG4964	Belongs to the GSP D family
E2R23_RS14855	COG1522	sequence-specific DNA binding
E2R23_RS14875	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS14880	COG1113	amino acid transport
E2R23_RS14900	COG2271	Major facilitator Superfamily
E2R23_RS14975	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E2R23_RS14985	COG3546	catalase activity
E2R23_RS14990	COG3685	Protein conserved in bacteria
E2R23_RS15070	COG0517	IMP dehydrogenase activity
E2R23_RS15070	COG0516	GMP reductase activity
E2R23_RS15090	COG1573	uracil-dna glycosylase
E2R23_RS15095	COG1914	H( )-stimulated, divalent metal cation uptake system
E2R23_RS15115	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS15140	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS15145	COG2823	Periplasmic or secreted lipoprotein
E2R23_RS15160	COG2198	Histidine kinase
E2R23_RS15160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2R23_RS15160	COG0784	Response regulator, receiver
E2R23_RS15160	COG2205	protein histidine kinase activity
E2R23_RS15175	COG2204	response regulator
E2R23_RS15210	COG2192	nodulation
E2R23_RS15215	COG0859	PFAM glycosyl transferase family 9
E2R23_RS15220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E2R23_RS15225	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS15235	COG5265	(ABC) transporter
E2R23_RS15255	COG0688	phosphatidylethanolamine metabolic process
E2R23_RS15260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E2R23_RS15275	COG2084	Dehydrogenase
E2R23_RS15280	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2R23_RS15290	COG2091	lysine biosynthetic process via aminoadipic acid
E2R23_RS15310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E2R23_RS15340	COG0022	dehydrogenase e1 component
E2R23_RS15400	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2R23_RS15460	COG2239	Acts as a magnesium transporter
E2R23_RS15475	COG0071	Belongs to the small heat shock protein (HSP20) family
E2R23_RS15500	COG2909	trisaccharide binding
E2R23_RS15515	COG2175	clavaminate synthase activity
E2R23_RS15520	COG3246	L-lysine catabolic process to acetate
E2R23_RS15550	COG0243	molybdopterin cofactor binding
E2R23_RS15555	COG0437	4 iron, 4 sulfur cluster binding
E2R23_RS15560	COG3302	dmso reductase anchor subunit
E2R23_RS15630	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS15640	COG0154	amidase activity
E2R23_RS15665	COG0456	acetyltransferase
E2R23_RS15665	COG0454	-acetyltransferase
E2R23_RS15730	COG5002	protein histidine kinase activity
E2R23_RS15730	COG3447	MASE1 domain protein
E2R23_RS15730	COG5001	Diguanylate cyclase
E2R23_RS15775	COG1136	(ABC) transporter
E2R23_RS15780	COG2072	flavoprotein involved in K transport
E2R23_RS15790	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS15815	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E2R23_RS15825	COG1126	abc transporter atp-binding protein
E2R23_RS15830	COG0765	amino acid transport
E2R23_RS15835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2R23_RS15850	COG1657	PFAM Prenyltransferase squalene oxidase
E2R23_RS15860	COG1562	ergosterol biosynthetic process
E2R23_RS15910	COG1595	DNA-templated transcription, initiation
E2R23_RS15920	COG1393	Belongs to the ArsC family
E2R23_RS15930	COG1192	Involved in chromosome partitioning
E2R23_RS15985	COG0523	cobalamin synthesis protein
E2R23_RS16010	COG1459	type II secretion system
E2R23_RS16030	COG2165	general secretion pathway protein
E2R23_RS16075	COG1846	Transcriptional regulator
E2R23_RS16080	COG2814	Major facilitator Superfamily
E2R23_RS16085	COG0583	DNA-binding transcription factor activity
E2R23_RS16095	COG1346	cytolysis
E2R23_RS16115	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E2R23_RS16130	COG1987	bacterial-type flagellum assembly
E2R23_RS16140	COG0789	Transcriptional regulator
E2R23_RS16145	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E2R23_RS16145	COG4106	trans-aconitate 2-methyltransferase activity
E2R23_RS16155	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2R23_RS16165	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2R23_RS16180	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS16205	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS16285	COG1695	Transcriptional regulator
E2R23_RS16320	COG1960	acyl-CoA dehydrogenase activity
E2R23_RS16330	COG0183	Belongs to the thiolase family
E2R23_RS16335	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2R23_RS16335	COG1024	Enoyl-CoA hydratase
E2R23_RS16340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2R23_RS16385	COG0753	catalase activity
E2R23_RS16415	COG0592	DNA-directed DNA polymerase activity
E2R23_RS16485	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E2R23_RS16515	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E2R23_RS16515	COG2169	Transcriptional regulator
E2R23_RS16530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E2R23_RS16560	COG0583	DNA-binding transcription factor activity
E2R23_RS16575	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E2R23_RS16590	COG4695	Portal protein
E2R23_RS16630	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E2R23_RS16635	COG0583	DNA-binding transcription factor activity
E2R23_RS16655	COG0758	DNA mediated transformation
E2R23_RS16660	COG0242	peptide deformylase activity
E2R23_RS16685	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E2R23_RS16685	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E2R23_RS16695	COG5000	phosphorelay sensor kinase activity
E2R23_RS16700	COG2204	response regulator
E2R23_RS16905	COG4695	Portal protein
E2R23_RS16910	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E2R23_RS16915	COG3657	addiction module killer protein
E2R23_RS16935	COG0602	queuosine metabolic process
E2R23_RS16940	COG0720	synthase
E2R23_RS16965	COG0772	Belongs to the SEDS family
E2R23_RS16985	COG1077	Cell shape determining protein MreB Mrl
E2R23_RS17005	COG2326	polyphosphate kinase activity
E2R23_RS17010	COG0708	Exodeoxyribonuclease III
E2R23_RS17020	COG1064	alcohol dehydrogenase
E2R23_RS17025	COG2207	Transcriptional regulator
E2R23_RS17035	COG2814	Major facilitator Superfamily
E2R23_RS17050	COG1309	transcriptional regulator
E2R23_RS17080	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E2R23_RS17110	COG0523	cobalamin synthesis protein
E2R23_RS17120	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E2R23_RS17135	COG1560	Kdo2-lipid A biosynthetic process
E2R23_RS17165	COG0667	Aldo Keto reductase
E2R23_RS17185	COG2814	Major facilitator Superfamily
E2R23_RS17195	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E2R23_RS17210	COG1960	acyl-CoA dehydrogenase activity
E2R23_RS17270	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E2R23_RS17285	COG0531	amino acid
E2R23_RS17305	COG1280	lysine exporter protein (LysE YggA)
E2R23_RS17310	COG3568	Endonuclease Exonuclease Phosphatase
E2R23_RS17330	COG0579	oxidoreductase
E2R23_RS17350	COG0747	negative chemotaxis
E2R23_RS17355	COG0601	transmembrane transport
E2R23_RS17360	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E2R23_RS17365	COG0444	Belongs to the ABC transporter superfamily
E2R23_RS17370	COG4608	Belongs to the ABC transporter superfamily
E2R23_RS17400	COG1984	allophanate hydrolase subunit 2
E2R23_RS17405	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E2R23_RS17415	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E2R23_RS17420	COG0741	lytic transglycosylase activity
E2R23_RS17465	COG2747	anti-sigma28 factor FlgM
E2R23_RS17475	COG1815	bacterial-type flagellum-dependent cell motility
E2R23_RS17480	COG1558	bacterial-type flagellum-dependent cell motility
E2R23_RS17485	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E2R23_RS17490	COG1749	Flagellar hook protein flgE
E2R23_RS17505	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E2R23_RS17510	COG1706	bacterial-type flagellum-dependent cell motility
E2R23_RS17520	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
E2R23_RS17530	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E2R23_RS17540	COG2233	PERMEase
E2R23_RS17550	COG0583	DNA-binding transcription factor activity
E2R23_RS17580	COG2824	Alkylphosphonate utilization operon protein PhnA
E2R23_RS17600	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS17715	COG1704	LemA family
E2R23_RS17720	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E2R23_RS17740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2R23_RS17745	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2R23_RS17760	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E2R23_RS17820	COG1609	Transcriptional regulator
E2R23_RS17825	COG0840	transmembrane signaling receptor activity
E2R23_RS17845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS17850	COG0583	DNA-binding transcription factor activity
E2R23_RS17865	COG0596	Alpha beta hydrolase
E2R23_RS17895	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2R23_RS17915	COG3511	phospholipase C
E2R23_RS17950	COG1999	signal sequence binding
E2R23_RS17970	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2R23_RS18045	COG0025	NhaP-type Na H and K H
E2R23_RS18050	COG2199	diguanylate cyclase activity
E2R23_RS18050	COG2200	EAL domain
E2R23_RS18060	COG1785	Belongs to the alkaline phosphatase family
E2R23_RS18090	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E2R23_RS18110	COG3012	SEC-C Motif Domain Protein
E2R23_RS18120	COG0183	Belongs to the thiolase family
E2R23_RS18125	COG0288	reversible hydration of carbon dioxide
E2R23_RS18145	COG0488	(ABC) transporter
E2R23_RS18150	COG0747	negative chemotaxis
E2R23_RS18170	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS18175	COG4221	oxidoreductase activity
E2R23_RS18180	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E2R23_RS18240	COG1024	Enoyl-CoA hydratase
E2R23_RS18265	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E2R23_RS18275	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E2R23_RS18290	COG0737	Belongs to the 5'-nucleotidase family
E2R23_RS18295	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E2R23_RS18300	COG1127	ABC transporter
E2R23_RS18335	COG1686	Belongs to the peptidase S11 family
E2R23_RS18345	COG2921	Belongs to the UPF0250 family
E2R23_RS18350	COG0583	DNA-binding transcription factor activity
E2R23_RS18385	COG0583	DNA-binding transcription factor activity
E2R23_RS18390	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2R23_RS18390	COG1024	Enoyl-CoA hydratase
E2R23_RS18395	COG1960	acyl-CoA dehydrogenase activity
E2R23_RS18400	COG1960	acyl-CoA dehydrogenase activity
E2R23_RS18405	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2R23_RS18420	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E2R23_RS18435	COG4191	Histidine kinase
E2R23_RS18445	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E2R23_RS18485	COG2960	long-chain fatty acid transporting porin activity
E2R23_RS18495	COG0004	ammonium transporteR
E2R23_RS18510	COG0189	ligase activity
E2R23_RS18520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E2R23_RS18525	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E2R23_RS18535	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E2R23_RS18540	COG0793	Belongs to the peptidase S41A family
E2R23_RS18550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E2R23_RS18570	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E2R23_RS18585	COG1040	competence protein
E2R23_RS18590	COG2226	methyltransferase
E2R23_RS18605	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E2R23_RS18615	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E2R23_RS18645	COG1612	heme a metabolic process
E2R23_RS18655	COG1999	signal sequence binding
E2R23_RS18670	COG0840	transmembrane signaling receptor activity
E2R23_RS18700	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E2R23_RS18715	COG0587	DNA-directed DNA polymerase activity
E2R23_RS18725	COG2814	Major facilitator Superfamily
E2R23_RS18760	COG2226	methyltransferase
E2R23_RS18770	COG1960	acyl-CoA dehydrogenase activity
E2R23_RS18780	COG0318	PFAM AMP-dependent synthetase and ligase
E2R23_RS18825	COG0583	DNA-binding transcription factor activity
E2R23_RS18835	COG2188	Transcriptional regulator
E2R23_RS18840	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E2R23_RS18845	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E2R23_RS18850	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E2R23_RS18850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E2R23_RS18855	COG1263	PTS System
E2R23_RS18855	COG2190	(PTS) system
E2R23_RS18855	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E2R23_RS18880	COG1294	oxidase, subunit
E2R23_RS18895	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E2R23_RS18905	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E2R23_RS18915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E2R23_RS18930	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E2R23_RS18935	COG0243	molybdopterin cofactor binding
E2R23_RS18945	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2R23_RS18955	COG0625	glutathione transferase activity
E2R23_RS18965	COG0742	ribosomal rna small subunit methyltransferase
E2R23_RS18980	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E2R23_RS19000	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E2R23_RS19015	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E2R23_RS19030	COG1194	a g-specific adenine glycosylase
E2R23_RS19055	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E2R23_RS19065	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E2R23_RS19070	COG1137	ATPase activity
E2R23_RS19085	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E2R23_RS19110	COG1280	lysine exporter protein (LysE YggA)
E2R23_RS19140	COG2814	Major facilitator Superfamily
E2R23_RS19295	COG0235	Class ii aldolase
E2R23_RS19310	COG5002	protein histidine kinase activity
E2R23_RS19310	COG5001	Diguanylate cyclase
E2R23_RS19360	COG2204	response regulator
E2R23_RS19380	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E2R23_RS19390	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E2R23_RS19410	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E2R23_RS19415	COG1596	polysaccharide export
E2R23_RS19455	COG0477	Major facilitator Superfamily
E2R23_RS19480	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E2R23_RS19485	COG0251	oxidation-reduction process
E2R23_RS19495	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E2R23_RS19565	COG0494	nUDIX hydrolase
E2R23_RS19580	COG1960	acyl-CoA dehydrogenase activity
E2R23_RS19585	COG1024	Enoyl-CoA hydratase
E2R23_RS19585	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2R23_RS19590	COG0183	Belongs to the thiolase family
E2R23_RS19595	COG1024	Enoyl-CoA hydratase
E2R23_RS19600	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E2R23_RS19620	COG5265	(ABC) transporter
E2R23_RS19630	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E2R23_RS19635	COG3178	'Phosphotransferase
E2R23_RS19650	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E2R23_RS19680	COG0204	Acyl-transferase
E2R23_RS19685	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E2R23_RS19690	COG0751	glycine-tRNA ligase activity
E2R23_RS19695	COG0752	glycyl-tRNA synthetase alpha subunit
E2R23_RS19700	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E2R23_RS19710	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
E2R23_RS19725	COG1702	phosphate starvation-inducible protein PhoH
E2R23_RS19740	COG0583	DNA-binding transcription factor activity
E2R23_RS19745	COG2814	Major facilitator Superfamily
E2R23_RS19750	COG1396	sequence-specific DNA binding
E2R23_RS19760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E2R23_RS19775	COG0367	asparagine synthase
E2R23_RS19780	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E2R23_RS19785	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E2R23_RS19800	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E2R23_RS19805	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E2R23_RS19850	COG0513	Belongs to the DEAD box helicase family
E2R23_RS19885	COG4948	Mandelate Racemase Muconate Lactonizing
E2R23_RS19935	COG0840	transmembrane signaling receptor activity
E2R23_RS19960	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E2R23_RS20045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E2R23_RS20050	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E2R23_RS20055	COG0028	Belongs to the TPP enzyme family
E2R23_RS20095	COG0583	DNA-binding transcription factor activity
E2R23_RS20100	COG5002	protein histidine kinase activity
E2R23_RS20100	COG0784	Response regulator, receiver
E2R23_RS20155	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E2R23_RS20160	COG2137	regulation of response to DNA damage stimulus
E2R23_RS20175	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E2R23_RS20180	COG0861	Integral membrane protein TerC family
E2R23_RS20185	COG4969	Belongs to the N-Me-Phe pilin family
E2R23_RS20190	COG3307	-O-antigen
E2R23_RS20220	COG4783	chaperone-mediated protein folding
E2R23_RS20230	COG0429	hydrolase of the alpha beta-hydrolase fold
E2R23_RS20240	COG0859	PFAM glycosyl transferase family 9
E2R23_RS20265	COG0126	phosphoglycerate kinase activity
E2R23_RS20275	COG0469	pyruvate kinase activity
E2R23_RS20285	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E2R23_RS20290	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E2R23_RS20295	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E2R23_RS20300	COG0009	L-threonylcarbamoyladenylate synthase
E2R23_RS20345	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2R23_RS20375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2R23_RS20380	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2R23_RS20395	COG2233	PERMEase
E2R23_RS20400	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E2R23_RS20415	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E2R23_RS20420	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E2R23_RS20425	COG1121	(ABC) transporter
E2R23_RS20435	COG0735	belongs to the Fur family
E2R23_RS20445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E2R23_RS20460	COG1175	transmembrane transport
E2R23_RS20470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E2R23_RS20475	COG3842	ATPase activity
E2R23_RS20490	COG0583	DNA-binding transcription factor activity
E2R23_RS20505	COG2390	Transcriptional regulator
E2R23_RS20510	COG1070	Carbohydrate kinase
E2R23_RS20515	COG0246	Mannitol dehydrogenase
E2R23_RS20520	COG0583	DNA-binding transcription factor activity
E2R23_RS20530	COG1012	belongs to the aldehyde dehydrogenase family
E2R23_RS20535	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E2R23_RS20545	COG2271	Major facilitator Superfamily
E2R23_RS20565	COG1522	sequence-specific DNA binding
E2R23_RS20570	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E2R23_RS20580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E2R23_RS20590	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E2R23_RS20600	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E2R23_RS20610	COG3118	belongs to the thioredoxin family
E2R23_RS20615	COG1741	Belongs to the pirin family
E2R23_RS20625	COG0860	N-Acetylmuramoyl-L-alanine amidase
E2R23_RS20630	COG0802	atpase or kinase
E2R23_RS20635	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E2R23_RS20645	COG4974	Belongs to the 'phage' integrase family
E2R23_RS20650	COG0318	PFAM AMP-dependent synthetase and ligase
E2R23_RS20655	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E2R23_RS20670	COG0812	UDP-N-acetylmuramate dehydrogenase activity
E2R23_RS20675	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E2R23_RS20695	COG0728	peptidoglycan biosynthetic process
E2R23_RS20735	COG1663	tetraacyldisaccharide 4'-kinase activity
E2R23_RS20745	COG1570	exodeoxyribonuclease VII activity
E2R23_RS20750	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E2R23_RS20815	COG2814	Major facilitator Superfamily
E2R23_RS20835	COG2188	Transcriptional regulator
E2R23_RS20840	COG0656	L-ascorbic acid biosynthetic process
E2R23_RS20875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E2R23_RS20910	COG2132	Multicopper oxidase
E2R23_RS20915	COG1278	Cold shock
E2R23_RS20925	COG0542	response to heat
E2R23_RS20930	COG1113	amino acid transport
E2R23_RS20960	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E2R23_RS20965	COG0196	riboflavin kinase activity
E2R23_RS20970	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E2R23_RS20975	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E2R23_RS20975	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E2R23_RS20980	COG1511	domain protein
E2R23_RS20980	COG3264	Mechanosensitive ion channel
E2R23_RS21005	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E2R23_RS21025	COG1047	Peptidyl-prolyl cis-trans
E2R23_RS21030	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E2R23_RS21070	COG0456	acetyltransferase
E2R23_RS21075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E2R23_RS21080	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2R23_RS21080	COG0543	2 iron, 2 sulfur cluster binding
E2R23_RS21095	COG1187	pseudouridine synthase activity
E2R23_RS21105	COG0583	DNA-binding transcription factor activity
E2R23_RS21115	COG2267	carboxylic ester hydrolase activity
E2R23_RS21120	COG2258	MOSC domain
E2R23_RS21125	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2R23_RS21135	COG1396	sequence-specific DNA binding
E2R23_RS21145	COG2801	Transposase and inactivated derivatives
E2R23_RS21165	COG0583	DNA-binding transcription factor activity
E2R23_RS21180	COG0175	sulfate reduction
E2R23_RS21190	COG2895	sulfate adenylyltransferase (ATP) activity
E2R23_RS21195	COG1648	precorrin-2 dehydrogenase activity
E2R23_RS21195	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E2R23_RS21210	COG0795	lipopolysaccharide-transporting ATPase activity
E2R23_RS21230	COG4654	Cytochrome c, class I
E2R23_RS21245	COG0583	DNA-binding transcription factor activity
E2R23_RS21280	COG4206	TonB-dependent receptor
E2R23_RS21290	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E2R23_RS21295	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E2R23_RS21300	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E2R23_RS21320	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E2R23_RS21330	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E2R23_RS21340	COG1492	cobalamin metabolic process
E2R23_RS21345	COG2259	Doxx family
E2R23_RS21350	COG0489	protein tyrosine kinase activity
E2R23_RS21370	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E2R23_RS21380	COG0729	surface antigen
E2R23_RS21385	COG2911	Protein conserved in bacteria
E2R23_RS21425	COG0489	protein tyrosine kinase activity
E2R23_RS21450	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E2R23_RS21490	COG2226	methyltransferase
E2R23_RS21530	COG2271	Major facilitator Superfamily
E2R23_RS21545	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E2R23_RS21550	COG2827	Endonuclease containing a URI domain
E2R23_RS21585	COG0347	Belongs to the P(II) protein family
E2R23_RS21615	COG4215	(ABC) transporter
E2R23_RS21630	COG1741	Belongs to the pirin family
E2R23_RS21665	COG1176	ABC-type spermidine putrescine transport system, permease component I
E2R23_RS21670	COG1116	anion transmembrane transporter activity
E2R23_RS21700	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E2R23_RS21720	COG2814	Major facilitator Superfamily
E2R23_RS21725	COG1881	PFAM PEBP family protein
E2R23_RS21845	COG1773	rubredoxin
E2R23_RS21855	COG0488	(ABC) transporter
E2R23_RS21885	COG0583	DNA-binding transcription factor activity
E2R23_RS21900	COG0583	DNA-binding transcription factor activity
E2R23_RS21910	COG0477	Major facilitator Superfamily
E2R23_RS21955	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2R23_RS21960	COG0697	spore germination
E2R23_RS21970	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2R23_RS21995	COG4106	trans-aconitate 2-methyltransferase activity
E2R23_RS22010	COG2764	glyoxalase bleomycin resistance protein dioxygenase
E2R23_RS22025	COG3135	benzoate transporter
E2R23_RS22060	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E2R23_RS22065	COG2878	Part of a membrane complex involved in electron transport
E2R23_RS22070	COG1309	transcriptional regulator
E2R23_RS22080	COG3387	PFAM Glycoside hydrolase 15-related
E2R23_RS22090	COG2706	6-phosphogluconolactonase activity
E2R23_RS22135	COG0513	Belongs to the DEAD box helicase family
E2R23_RS22145	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E2R23_RS22185	COG0438	transferase activity, transferring glycosyl groups
E2R23_RS22190	COG0859	PFAM glycosyl transferase family 9
E2R23_RS22235	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E2R23_RS22245	COG1595	DNA-templated transcription, initiation
E2R23_RS22300	COG2233	PERMEase
E2R23_RS22325	COG0799	negative regulation of ribosome biogenesis
E2R23_RS22340	COG0151	Belongs to the GarS family
E2R23_RS22360	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS22390	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E2R23_RS22395	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E2R23_RS22410	COG2205	protein histidine kinase activity
E2R23_RS22415	COG0745	RESPONSE REGULATOR receiver
E2R23_RS22450	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E2R23_RS22460	COG0154	amidase activity
E2R23_RS22470	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E2R23_RS22480	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS22500	COG0438	transferase activity, transferring glycosyl groups
E2R23_RS22535	COG0028	Belongs to the TPP enzyme family
E2R23_RS22555	COG1183	phosphatidylcholine synthase activity
E2R23_RS22565	COG0659	secondary active sulfate transmembrane transporter activity
E2R23_RS22570	COG0288	reversible hydration of carbon dioxide
E2R23_RS22585	COG0683	leucine binding
E2R23_RS22605	COG4221	oxidoreductase activity
E2R23_RS22605	COG3321	synthase
E2R23_RS22605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E2R23_RS22605	COG0604	alcohol dehydrogenase
E2R23_RS22610	COG0149	triose-phosphate isomerase activity
E2R23_RS22645	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E2R23_RS22655	COG1034	ATP synthesis coupled electron transport
E2R23_RS22690	COG1007	ATP synthesis coupled electron transport
E2R23_RS22710	COG1960	acyl-CoA dehydrogenase activity
E2R23_RS22715	COG1960	acyl-CoA dehydrogenase activity
E2R23_RS22720	COG1012	belongs to the aldehyde dehydrogenase family
E2R23_RS22720	COG2030	dehydratase
E2R23_RS22740	COG1960	acyl-CoA dehydrogenase activity
E2R23_RS22750	COG0588	phosphoglycerate mutase activity
E2R23_RS22755	COG1024	Enoyl-CoA hydratase
E2R23_RS22765	COG0436	Aminotransferase
E2R23_RS22780	COG2866	Carboxypeptidase
E2R23_RS22855	COG0006	proline dipeptidase activity
E2R23_RS22870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E2R23_RS22890	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E2R23_RS22925	COG2863	cytochrome
E2R23_RS22930	COG2010	Cytochrome c
E2R23_RS22930	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E2R23_RS22945	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E2R23_RS22985	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2R23_RS22990	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2R23_RS23025	COG1959	2 iron, 2 sulfur cluster binding
E2R23_RS23045	COG1522	sequence-specific DNA binding
E2R23_RS23050	COG3842	ATPase activity
E2R23_RS23055	COG1176	ABC-type spermidine putrescine transport system, permease component I
E2R23_RS23060	COG1840	ABC-type Fe3 transport system, periplasmic component
E2R23_RS23085	COG1289	transmembrane transporter activity
E2R23_RS23095	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E2R23_RS23100	COG1074	ATP-dependent DNA helicase activity
E2R23_RS23105	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E2R23_RS23115	COG2200	EAL domain
E2R23_RS23170	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
E2R23_RS23175	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E2R23_RS23190	COG0697	spore germination
E2R23_RS23200	COG2814	Major facilitator Superfamily
E2R23_RS23225	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E2R23_RS23235	COG3842	ATPase activity
E2R23_RS23245	COG1177	transmembrane transport
E2R23_RS23260	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E2R23_RS23265	COG1840	ABC-type Fe3 transport system, periplasmic component
E2R23_RS23270	COG1609	Transcriptional regulator
E2R23_RS23335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2R23_RS23340	COG1522	sequence-specific DNA binding
E2R23_RS23370	COG0583	DNA-binding transcription factor activity
E2R23_RS23410	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E2R23_RS23455	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E2R23_RS23460	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2R23_RS23470	COG0583	DNA-binding transcription factor activity
E2R23_RS23495	COG3052	prosthetic group binding
E2R23_RS23515	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E2R23_RS23525	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E2R23_RS23555	COG0477	Major facilitator Superfamily
E2R23_RS23570	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E2R23_RS23575	COG0328	RNA-DNA hybrid ribonuclease activity
E2R23_RS23580	COG2226	methyltransferase
E2R23_RS23585	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E2R23_RS23590	COG0741	lytic transglycosylase activity
E2R23_RS23590	COG1388	LysM domain
E2R23_RS23620	COG0505	Belongs to the CarA family
E2R23_RS23630	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E2R23_RS23635	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E2R23_RS23645	COG1534	Rna-binding protein
E2R23_RS23655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E2R23_RS23660	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E2R23_RS23665	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E2R23_RS23675	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E2R23_RS23680	COG0573	inorganic phosphate transmembrane transporter activity
E2R23_RS23685	COG0581	inorganic phosphate transmembrane transporter activity
E2R23_RS23700	COG0745	RESPONSE REGULATOR receiver
E2R23_RS23715	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E2R23_RS23795	COG0534	Mate efflux family protein
E2R23_RS23805	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E2R23_RS23810	COG4942	peptidase
E2R23_RS23930	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E2R23_RS23940	COG1846	Transcriptional regulator
E2R23_RS23945	COG1929	Belongs to the glycerate kinase type-1 family
E2R23_RS23975	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E2R23_RS24050	COG4181	ATPase activity
E2R23_RS24065	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2R23_RS24075	COG0047	phosphoribosylformylglycinamidine synthase activity
E2R23_RS24075	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E2R23_RS24085	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E2R23_RS24110	COG0318	PFAM AMP-dependent synthetase and ligase
E2R23_RS24120	COG1250	3-hydroxyacyl-CoA dehydrogenase
E2R23_RS24120	COG1024	Enoyl-CoA hydratase
E2R23_RS24125	COG1335	isochorismatase
E2R23_RS24130	COG0183	Belongs to the thiolase family
E2R23_RS24165	COG2130	NADP-dependent
E2R23_RS24170	COG0657	acetylesterase activity
E2R23_RS24185	COG0354	folic acid binding
E2R23_RS24190	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E2R23_RS24205	COG1247	-acetyltransferase
E2R23_RS24210	COG0084	hydrolase, TatD family'
E2R23_RS24240	COG0438	transferase activity, transferring glycosyl groups
E2R23_RS24275	COG0252	asparaginase activity
E2R23_RS24285	COG1652	LysM domain
E2R23_RS24295	COG2084	Dehydrogenase
E2R23_RS24300	COG3622	Belongs to the hyi family
E2R23_RS24305	COG3960	tartronate-semialdehyde synthase activity
E2R23_RS24310	COG0583	DNA-binding transcription factor activity
E2R23_RS24325	COG1595	DNA-templated transcription, initiation
E2R23_RS24370	COG0306	phosphate transporter
E2R23_RS24380	COG0791	NLP P60 protein
E2R23_RS24385	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E2R23_RS24395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E2R23_RS24400	COG0726	polysaccharide deacetylase
E2R23_RS24405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E2R23_RS24405	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E2R23_RS24415	COG0463	Glycosyl transferase, family 2
E2R23_RS24420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E2R23_RS24425	COG2076	Multidrug Resistance protein
E2R23_RS24430	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E2R23_RS24440	COG0436	Aminotransferase
E2R23_RS24470	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E2R23_RS24475	COG0314	molybdopterin synthase activity
E2R23_RS24480	COG2346	COG2346, Truncated hemoglobins
E2R23_RS24485	COG1959	2 iron, 2 sulfur cluster binding
E2R23_RS24490	COG0542	response to heat
E2R23_RS24520	COG0534	Mate efflux family protein
E2R23_RS24540	COG3228	Belongs to the MtfA family
E2R23_RS24545	COG0477	Major facilitator Superfamily
E2R23_RS24550	COG0789	Transcriptional regulator
E2R23_RS24555	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E2R23_RS24580	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E2R23_RS24595	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2R23_RS24640	COG0670	Belongs to the BI1 family
E2R23_RS24675	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2R23_RS24690	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E2R23_RS24695	COG0330	HflC and HflK could
E2R23_RS24700	COG0330	HflC and HflK could
E2R23_RS24725	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E2R23_RS24735	COG3158	transport of potassium into the cell
E2R23_RS24745	COG2183	response to ionizing radiation
E2R23_RS24760	COG1199	ATP-dependent helicase activity
E2R23_RS24775	COG0564	pseudouridine synthase activity
E2R23_RS24780	COG1496	oxidoreductase activity
E2R23_RS24785	COG3243	poly(R)-hydroxyalkanoic acid synthase
E2R23_RS24790	COG0183	Belongs to the thiolase family
E2R23_RS24795	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS24820	COG0183	Belongs to the thiolase family
E2R23_RS24830	COG0626	cystathionine gamma-synthase activity
E2R23_RS24835	COG0560	Phosphoserine phosphatase
E2R23_RS24860	COG0390	transport system, permease component
E2R23_RS24865	COG1122	ATPase activity
E2R23_RS24870	COG2982	Protein involved in outer membrane biogenesis
E2R23_RS24880	COG0488	(ABC) transporter
E2R23_RS24900	COG2070	2-Nitropropane dioxygenase
E2R23_RS24905	COG3047	cAMP biosynthetic process
E2R23_RS24920	COG1914	H( )-stimulated, divalent metal cation uptake system
E2R23_RS24925	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E2R23_RS24930	COG3842	ATPase activity
E2R23_RS24935	COG1176	ABC-type spermidine putrescine transport system, permease component I
E2R23_RS24940	COG1177	transmembrane transport
E2R23_RS24950	COG0730	response to heat
E2R23_RS24950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2R23_RS24975	COG3655	Transcriptional regulator
E2R23_RS25005	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2R23_RS25020	COG0038	chloride channel
E2R23_RS25025	COG2855	membrane
E2R23_RS25045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E2R23_RS25065	COG1609	Transcriptional regulator
E2R23_RS25150	COG0598	Magnesium transport protein CorA
E2R23_RS25195	COG3264	Mechanosensitive ion channel
E2R23_RS25195	COG1196	nuclear chromosome segregation
E2R23_RS25230	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E2R23_RS25245	COG4263	nitrous-oxide reductase activity
E2R23_RS25270	COG0840	transmembrane signaling receptor activity
E2R23_RS25280	COG2376	Dihydroxyacetone kinase
E2R23_RS25300	COG0475	glutathione-regulated potassium exporter activity
E2R23_RS25385	COG3121	Chaperone
E2R23_RS25445	COG2197	response regulator
E2R23_RS25515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2R23_RS25520	COG1012	belongs to the aldehyde dehydrogenase family
E2R23_RS25535	COG1176	ABC-type spermidine putrescine transport system, permease component I
E2R23_RS25545	COG3842	ATPase activity
E2R23_RS25560	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS25580	COG2916	Histone family protein nucleoid-structuring protein H-NS
E2R23_RS25610	COG2274	protein secretion by the type I secretion system
E2R23_RS25615	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E2R23_RS25625	COG0457	Tetratricopeptide repeat
E2R23_RS25625	COG0859	PFAM glycosyl transferase family 9
E2R23_RS25630	COG0529	Catalyzes the synthesis of activated sulfate
E2R23_RS25640	COG0745	RESPONSE REGULATOR receiver
E2R23_RS25670	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS25680	COG2986	histidine ammonia-lyase
E2R23_RS25690	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E2R23_RS25705	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E2R23_RS25730	COG1595	DNA-templated transcription, initiation
E2R23_RS25735	COG4944	Protein of unknown function (DUF1109)
E2R23_RS25755	COG3220	belongs to the UPF0276 family
E2R23_RS25785	COG2192	nodulation
E2R23_RS25810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E2R23_RS25830	COG0165	Argininosuccinate lyase
E2R23_RS25835	COG0137	argininosuccinate synthase activity
E2R23_RS25850	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E2R23_RS25860	COG3251	PFAM MbtH domain protein
E2R23_RS25880	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS25890	COG2207	Transcriptional regulator
E2R23_RS25900	COG0697	spore germination
E2R23_RS25905	COG0835	chemotaxis
E2R23_RS25930	COG0318	PFAM AMP-dependent synthetase and ligase
E2R23_RS25935	COG0477	Major facilitator Superfamily
E2R23_RS25955	COG1732	Glycine betaine
E2R23_RS25960	COG1174	glycine betaine transport
E2R23_RS25965	COG1125	glycine betaine transport
E2R23_RS25970	COG1174	glycine betaine transport
E2R23_RS25995	COG2235	arginine
E2R23_RS26000	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E2R23_RS26025	COG0583	DNA-binding transcription factor activity
E2R23_RS26030	COG0625	glutathione transferase activity
E2R23_RS26045	COG1846	Transcriptional regulator
E2R23_RS26050	COG2807	transmembrane transport
E2R23_RS26055	COG1649	PFAM Uncharacterised BCR, COG1649
E2R23_RS26075	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E2R23_RS26085	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E2R23_RS26105	COG3979	chitinase
E2R23_RS26125	COG0400	carboxylic ester hydrolase activity
E2R23_RS26160	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
E2R23_RS26185	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E2R23_RS26190	COG4774	siderophore transport
E2R23_RS26195	COG3486	L-lysine 6-monooxygenase (NADPH) activity
E2R23_RS26245	COG1120	ATPase activity
E2R23_RS26275	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS26285	COG1063	alcohol dehydrogenase
E2R23_RS26295	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2R23_RS26300	COG1129	ABC transporter
E2R23_RS26305	COG1879	ABC-type sugar transport system periplasmic component
E2R23_RS26340	COG1132	(ABC) transporter
E2R23_RS26340	COG2375	cellular response to nickel ion
E2R23_RS26350	COG3121	Chaperone
E2R23_RS26360	COG3539	Fimbrial protein
E2R23_RS26390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E2R23_RS26400	COG1309	transcriptional regulator
E2R23_RS26410	COG0739	heme binding
E2R23_RS26415	COG0765	amino acid transport
E2R23_RS26420	COG4597	amino acid ABC transporter
E2R23_RS26435	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2R23_RS26485	COG4964	Belongs to the GSP D family
E2R23_RS26510	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2R23_RS26515	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E2R23_RS26530	COG0477	Major facilitator Superfamily
E2R23_RS26540	COG2719	SpoVR family
E2R23_RS26545	COG2718	Belongs to the UPF0229 family
E2R23_RS26550	COG2766	serine protein kinase
E2R23_RS26560	COG0840	transmembrane signaling receptor activity
E2R23_RS26565	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E2R23_RS26570	COG1609	Transcriptional regulator
E2R23_RS26575	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2R23_RS26580	COG1129	ABC transporter
E2R23_RS26585	COG1879	ABC-type sugar transport system periplasmic component
E2R23_RS26590	COG0583	DNA-binding transcription factor activity
E2R23_RS26595	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E2R23_RS26600	COG4208	sulfate ABC transporter
E2R23_RS26605	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E2R23_RS26610	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E2R23_RS26660	COG0701	Predicted permease
E2R23_RS26665	COG0667	Aldo Keto reductase
E2R23_RS26695	COG1301	dicarboxylic acid transport
E2R23_RS26735	COG1116	anion transmembrane transporter activity
E2R23_RS26740	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E2R23_RS26805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2R23_RS26810	COG0765	amino acid transport
E2R23_RS26815	COG0673	inositol 2-dehydrogenase activity
E2R23_RS26820	COG1802	Transcriptional regulator
E2R23_RS26830	COG3023	N-Acetylmuramoyl-L-alanine amidase
E2R23_RS26840	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E2R23_RS26845	COG0557	exoribonuclease II activity
E2R23_RS26860	COG0840	transmembrane signaling receptor activity
E2R23_RS26890	COG0519	Catalyzes the synthesis of GMP from XMP
E2R23_RS26895	COG2814	Major facilitator Superfamily
E2R23_RS26905	COG0318	PFAM AMP-dependent synthetase and ligase
E2R23_RS26975	COG4964	Belongs to the GSP D family
E2R23_RS27040	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E2R23_RS27045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2R23_RS27050	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2R23_RS27055	COG0567	Dehydrogenase, E1 component
E2R23_RS27070	COG1217	gtp-binding protein TYPA
E2R23_RS27080	COG1846	Transcriptional regulator
E2R23_RS27090	COG1566	PFAM secretion protein HlyD family protein
E2R23_RS27095	COG2814	Major facilitator Superfamily
E2R23_RS27105	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E2R23_RS27120	COG0195	Participates in both transcription termination and antitermination
E2R23_RS27120	COG2251	uridine kinase activity
E2R23_RS27130	COG1187	pseudouridine synthase activity
E2R23_RS27140	COG0583	DNA-binding transcription factor activity
E2R23_RS27200	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E2R23_RS27225	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E2R23_RS27225	COG2755	lipolytic protein G-D-S-L family
E2R23_RS27240	COG0776	regulation of translation
E2R23_RS27245	COG0072	phenylalanine-tRNA ligase activity
E2R23_RS27245	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E2R23_RS27265	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E2R23_RS27280	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E2R23_RS27285	COG0251	oxidation-reduction process
E2R23_RS27300	COG0583	DNA-binding transcription factor activity
E2R23_RS27315	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS27365	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS27390	COG0477	Major facilitator Superfamily
E2R23_RS27415	COG1295	ribonuclease BN
E2R23_RS27430	COG0277	FAD linked oxidase domain protein
E2R23_RS27445	COG0583	DNA-binding transcription factor activity
E2R23_RS27475	COG0840	transmembrane signaling receptor activity
E2R23_RS27480	COG2223	nitrite transmembrane transporter activity
E2R23_RS27485	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E2R23_RS27490	COG0210	DNA helicase
E2R23_RS27495	COG0525	valine-tRNA ligase activity
E2R23_RS27500	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E2R23_RS27510	COG5002	protein histidine kinase activity
E2R23_RS27520	COG0745	RESPONSE REGULATOR receiver
E2R23_RS27530	COG0425	Belongs to the sulfur carrier protein TusA family
E2R23_RS27540	COG0673	inositol 2-dehydrogenase activity
E2R23_RS27545	COG0673	inositol 2-dehydrogenase activity
E2R23_RS27560	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2R23_RS27575	COG3962	Belongs to the TPP enzyme family
E2R23_RS27585	COG3718	enzyme involved in inositol metabolism
E2R23_RS27595	COG0411	ABC transporter
E2R23_RS27605	COG0824	Thioesterase
E2R23_RS27630	COG2816	NAD+ diphosphatase activity
E2R23_RS27645	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2R23_RS27670	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E2R23_RS27680	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E2R23_RS27690	COG0494	nUDIX hydrolase
E2R23_RS27720	COG1858	cytochrome C peroxidase
E2R23_RS27725	COG3511	phospholipase C
E2R23_RS27740	COG1566	PFAM secretion protein HlyD family protein
E2R23_RS27750	COG2814	Major facilitator Superfamily
E2R23_RS27755	COG1538	Outer membrane efflux protein
E2R23_RS27765	COG2197	response regulator
E2R23_RS27820	COG0583	DNA-binding transcription factor activity
E2R23_RS27830	COG2814	Major facilitator Superfamily
E2R23_RS28020	COG0859	PFAM glycosyl transferase family 9
E2R23_RS28020	COG0457	Tetratricopeptide repeat
E2R23_RS28065	COG0745	RESPONSE REGULATOR receiver
E2R23_RS28070	COG0583	DNA-binding transcription factor activity
E2R23_RS28120	COG0366	Alpha amylase catalytic
E2R23_RS28125	COG0366	Alpha amylase catalytic
E2R23_RS28175	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E2R23_RS28260	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E2R23_RS28275	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E2R23_RS28360	COG3360	Dodecin
E2R23_RS28370	COG0583	DNA-binding transcription factor activity
E2R23_RS28385	COG2351	hydroxyisourate hydrolase activity
E2R23_RS28405	COG4266	Belongs to the allantoicase family
E2R23_RS28410	COG3195	allantoin biosynthetic process
E2R23_RS28410	COG3648	Uricase
E2R23_RS28425	COG1953	Uracil, thiamine, allantoin
E2R23_RS28435	COG1619	proteins homologs of microcin C7 resistance protein MccF
E2R23_RS28475	COG2814	Major facilitator Superfamily
E2R23_RS28530	COG0697	spore germination
E2R23_RS28540	COG2867	negative regulation of translational initiation
E2R23_RS28600	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E2R23_RS28640	COG0750	zinc metalloprotease
E2R23_RS28655	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E2R23_RS28685	COG0024	Methionine aminopeptidase
E2R23_RS28700	COG0242	peptide deformylase activity
E2R23_RS28745	COG1393	Belongs to the ArsC family
E2R23_RS28755	COG2890	protein-(glutamine-N5) methyltransferase activity
E2R23_RS28770	COG0386	Belongs to the glutathione peroxidase family
E2R23_RS28775	COG0488	(ABC) transporter
E2R23_RS28795	COG0477	Major facilitator Superfamily
E2R23_RS28800	COG0351	phosphomethylpyrimidine kinase
E2R23_RS28815	COG1573	uracil-dna glycosylase
E2R23_RS28825	COG1214	PFAM Peptidase M22, glycoprotease
E2R23_RS28835	COG0513	Belongs to the DEAD box helicase family
E2R23_RS28840	COG2224	Isocitrate lyase
E2R23_RS28850	COG0583	DNA-binding transcription factor activity
E2R23_RS28860	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E2R23_RS28925	COG1752	Esterase of the alpha-beta hydrolase superfamily
E2R23_RS28930	COG0791	NLP P60 protein
E2R23_RS28940	COG4172	Belongs to the ABC transporter superfamily
E2R23_RS28945	COG4239	(ABC) transporter, permease
E2R23_RS28950	COG4174	ABC transporter (Permease)
E2R23_RS28955	COG4166	transmembrane transport
E2R23_RS28980	COG0243	molybdopterin cofactor binding
E2R23_RS28995	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E2R23_RS29020	COG0024	Methionine aminopeptidase
E2R23_RS29040	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E2R23_RS29060	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E2R23_RS29075	COG3958	Transketolase
E2R23_RS29080	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E2R23_RS29100	COG2175	clavaminate synthase activity
E2R23_RS29130	COG0529	Catalyzes the synthesis of activated sulfate
E2R23_RS29130	COG2895	sulfate adenylyltransferase (ATP) activity
E2R23_RS29190	COG0527	aspartate kinase activity
E2R23_RS29200	COG0037	tRNA processing
E2R23_RS29225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E2R23_RS29235	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E2R23_RS29245	COG1045	serine acetyltransferase
E2R23_RS29260	COG0483	inositol monophosphate 1-phosphatase activity
E2R23_RS29290	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
E2R23_RS29305	COG2850	peptidyl-arginine hydroxylation
E2R23_RS29320	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E2R23_RS29325	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E2R23_RS29330	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E2R23_RS29340	COG0180	Tryptophanyl-tRNA synthetase
E2R23_RS29345	COG1994	Peptidase M50
E2R23_RS29350	COG0009	L-threonylcarbamoyladenylate synthase
E2R23_RS29355	COG0613	PHP domain protein
E2R23_RS29365	COG0596	Alpha beta hydrolase
E2R23_RS29375	COG2833	Protein of unknown function (DUF455)
E2R23_RS29385	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E2R23_RS29395	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E2R23_RS29420	COG2267	carboxylic ester hydrolase activity
E2R23_RS29425	COG0658	competence protein
E2R23_RS29425	COG2333	competence protein COMEC
E2R23_RS29430	COG0084	hydrolase, TatD family'
E2R23_RS29435	COG1136	(ABC) transporter
E2R23_RS29455	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E2R23_RS29480	COG2975	iron-sulfur cluster assembly
E2R23_RS29500	COG0316	Belongs to the HesB IscA family
E2R23_RS29505	COG0822	iron-sulfur transferase activity
E2R23_RS29510	COG1104	cysteine desulfurase activity
E2R23_RS29520	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E2R23_RS29545	COG1414	Transcriptional regulator
E2R23_RS29575	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E2R23_RS29585	COG0508	dehydrogenase complex catalyzes the overall conversion of
E2R23_RS29590	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E2R23_RS29600	COG4566	intracellular signal transduction
E2R23_RS29620	COG0339	signal peptide processing
E2R23_RS29625	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E2R23_RS29645	COG2223	nitrite transmembrane transporter activity
E2R23_RS29650	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E2R23_RS29655	COG1140	nitrate reductase beta subunit
E2R23_RS29660	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E2R23_RS29665	COG2181	nitrate reductase activity
E2R23_RS29670	COG4585	Histidine kinase
E2R23_RS29675	COG2197	response regulator
E2R23_RS29700	COG0174	glutamine synthetase
E2R23_RS29715	COG1546	Belongs to the CinA family
E2R23_RS29715	COG1058	Belongs to the CinA family
E2R23_RS29740	COG1643	Atp-dependent helicase
E2R23_RS29745	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E2R23_RS29745	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E2R23_RS29755	COG0477	Major facilitator Superfamily
E2R23_RS29770	COG1960	acyl-CoA dehydrogenase activity
E2R23_RS29775	COG0583	DNA-binding transcription factor activity
E2R23_RS29800	COG0174	glutamine synthetase
E2R23_RS29805	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E2R23_RS29845	COG0402	S-adenosylhomocysteine deaminase activity
E2R23_RS29860	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E2R23_RS29915	COG0529	Catalyzes the synthesis of activated sulfate
E2R23_RS29920	COG0415	Belongs to the DNA photolyase family
E2R23_RS29980	COG3154	lipid carrier protein
E2R23_RS29985	COG0826	peptidase U32
E2R23_RS29990	COG0826	peptidase U32
E2R23_RS30015	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E2R23_RS30020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E2R23_RS30025	COG0840	transmembrane signaling receptor activity
E2R23_RS30045	COG0719	Fe-S assembly protein
E2R23_RS30050	COG0396	ATPase activity
E2R23_RS30060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E2R23_RS30065	COG0822	iron-sulfur transferase activity
E2R23_RS30070	COG2151	metal-sulfur cluster biosynthetic enzyme
E2R23_RS30085	COG1959	2 iron, 2 sulfur cluster binding
E2R23_RS30115	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E2R23_RS30125	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2R23_RS30160	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E2R23_RS30220	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E2R23_RS30225	COG0596	Alpha beta hydrolase
E2R23_RS30235	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
E2R23_RS30245	COG3511	phospholipase C
E2R23_RS30255	COG0683	leucine binding
E2R23_RS30260	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2R23_RS30275	COG0438	transferase activity, transferring glycosyl groups
E2R23_RS30280	COG1132	(ABC) transporter
E2R23_RS30285	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E2R23_RS30300	COG1999	signal sequence binding
E2R23_RS30315	COG2153	protein acetylation
E2R23_RS30330	COG0583	DNA-binding transcription factor activity
E2R23_RS30335	COG1956	GAF domain-containing protein
E2R23_RS30360	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E2R23_RS30365	COG0322	excinuclease ABC activity
E2R23_RS30380	COG2204	response regulator
E2R23_RS30395	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E2R23_RS30405	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E2R23_RS30410	COG0571	ribonuclease III activity
E2R23_RS30415	COG0681	Belongs to the peptidase S26 family
E2R23_RS30430	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2R23_RS30435	COG3026	antisigma factor binding
E2R23_RS30455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E2R23_RS30495	COG1399	metal-binding, possibly nucleic acid-binding protein
E2R23_RS30520	COG0546	phosphoglycolate phosphatase activity
E2R23_RS30535	COG1530	ribonuclease E activity
E2R23_RS30540	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E2R23_RS30550	COG0303	'Molybdopterin
E2R23_RS30565	COG1322	Protein conserved in bacteria
E2R23_RS30585	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E2R23_RS30595	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E2R23_RS30610	COG3045	CreA protein
E2R23_RS30630	COG2501	S4 domain
E2R23_RS30635	COG0534	Mate efflux family protein
E2R23_RS30645	COG0114	fumarate hydratase activity
E2R23_RS30665	COG0640	Transcriptional regulator
E2R23_RS30675	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E2R23_RS30700	COG2204	response regulator
E2R23_RS30705	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
E2R23_RS30715	COG0312	modulator of DNA gyrase
E2R23_RS30725	COG3028	Belongs to the UPF0307 family
E2R23_RS30730	COG0521	Mo-molybdopterin cofactor biosynthetic process
E2R23_RS30740	COG0501	Belongs to the peptidase M48B family
E2R23_RS30755	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E2R23_RS30830	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E2R23_RS30835	COG1960	acyl-CoA dehydrogenase activity
E2R23_RS30855	COG2011	ABC-type metal ion transport system permease component
E2R23_RS30865	COG2267	carboxylic ester hydrolase activity
E2R23_RS30875	COG0123	including yeast histone deacetylase and acetoin utilization protein
E2R23_RS30880	COG2951	lytic endotransglycosylase activity
E2R23_RS30905	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E2R23_RS30915	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E2R23_RS30940	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E2R23_RS30950	COG1605	Chorismate mutase
E2R23_RS30950	COG0077	Prephenate dehydratase
E2R23_RS30955	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E2R23_RS30985	COG0546	phosphoglycolate phosphatase activity
E2R23_RS30995	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E2R23_RS31005	COG1910	domain protein
E2R23_RS31020	COG3383	formate dehydrogenase (NAD+) activity
E2R23_RS31060	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E2R23_RS31070	COG0154	amidase activity
E2R23_RS31090	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E2R23_RS31095	COG2252	PERMEase
E2R23_RS31100	COG0402	S-adenosylhomocysteine deaminase activity
E2R23_RS31110	COG2119	membrane
E2R23_RS31125	COG0308	aminopeptidase N
E2R23_RS31135	COG0583	DNA-binding transcription factor activity
E2R23_RS31195	COG4772	TonB-dependent receptor
E2R23_RS31215	COG2176	DNA-directed DNA polymerase activity
E2R23_RS31220	COG1278	Cold shock
E2R23_RS31230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS31250	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E2R23_RS31265	COG1561	YicC-like family, N-terminal region
E2R23_RS31275	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E2R23_RS31280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E2R23_RS31315	COG0477	Major facilitator Superfamily
E2R23_RS31325	COG0859	PFAM glycosyl transferase family 9
E2R23_RS31345	COG2894	cell division
E2R23_RS31390	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E2R23_RS31395	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E2R23_RS31400	COG1674	ftsk spoiiie
E2R23_RS31405	COG0492	ferredoxin-NADP+ reductase activity
E2R23_RS31410	COG1193	negative regulation of DNA recombination
E2R23_RS31415	COG2860	membrane
E2R23_RS31420	COG3842	ATPase activity
E2R23_RS31425	COG0395	ABC-type sugar transport system, permease component
E2R23_RS31430	COG1175	transmembrane transport
E2R23_RS31440	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E2R23_RS31445	COG0363	glucosamine-6-phosphate deaminase activity
E2R23_RS31450	COG1737	Transcriptional regulator
E2R23_RS31450	COG0837	glucose binding
E2R23_RS31460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2R23_RS31465	COG0765	amino acid transport
E2R23_RS31470	COG1126	abc transporter atp-binding protein
E2R23_RS31485	COG2814	Major facilitator Superfamily
E2R23_RS31510	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E2R23_RS31510	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E2R23_RS31540	COG0436	Aminotransferase
E2R23_RS31555	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E2R23_RS31590	COG0762	integral membrane protein
E2R23_RS31620	COG2226	methyltransferase
E2R23_RS31625	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E2R23_RS31660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E2R23_RS31670	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E2R23_RS31680	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E2R23_RS31695	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2R23_RS31705	COG1129	ABC transporter
E2R23_RS31760	COG0859	PFAM glycosyl transferase family 9
E2R23_RS31790	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E2R23_RS31805	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E2R23_RS31820	COG1215	transferase activity, transferring glycosyl groups
E2R23_RS31895	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E2R23_RS31915	COG1773	rubredoxin
E2R23_RS31930	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E2R23_RS31945	COG1733	regulation of RNA biosynthetic process
E2R23_RS31950	COG0604	alcohol dehydrogenase
E2R23_RS32010	COG1280	lysine exporter protein (LysE YggA)
E2R23_RS32020	COG0584	glycerophosphoryl diester phosphodiesterase
E2R23_RS32035	COG0730	response to heat
E2R23_RS32080	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E2R23_RS32090	COG1120	ATPase activity
E2R23_RS32095	COG4774	siderophore transport
E2R23_RS32120	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E2R23_RS32155	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E2R23_RS32165	COG0583	DNA-binding transcription factor activity
E2R23_RS32170	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E2R23_RS32175	COG0778	Nitroreductase
E2R23_RS32180	COG2814	Major facilitator Superfamily
E2R23_RS32205	COG2814	Major facilitator Superfamily
E2R23_RS32215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2R23_RS32250	COG1960	acyl-CoA dehydrogenase activity
E2R23_RS32260	COG0450	alkyl hydroperoxide reductase
E2R23_RS32320	COG4221	oxidoreductase activity
E2R23_RS32325	COG0824	Thioesterase
E2R23_RS32350	COG2885	chlorophyll binding
E2R23_RS32385	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E2R23_RS32385	COG0517	IMP dehydrogenase activity
E2R23_RS32390	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E2R23_RS32395	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E2R23_RS32410	COG1045	serine acetyltransferase
E2R23_RS32415	COG3562	capsule polysaccharide
E2R23_RS32425	COG3206	protein involved in exopolysaccharide biosynthesis
E2R23_RS32425	COG0489	protein tyrosine kinase activity
E2R23_RS32430	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E2R23_RS32480	COG0156	8-amino-7-oxononanoate synthase activity
E2R23_RS32485	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E2R23_RS32490	COG3321	synthase
E2R23_RS32490	COG0604	alcohol dehydrogenase
E2R23_RS32490	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS32495	COG1368	sulfuric ester hydrolase activity
E2R23_RS32510	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E2R23_RS32610	COG0586	Pfam SNARE associated Golgi protein
E2R23_RS32615	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E2R23_RS32655	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E2R23_RS32665	COG0617	tRNA 3'-terminal CCA addition
E2R23_RS32670	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E2R23_RS32675	COG1428	Deoxynucleoside kinase
E2R23_RS32685	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E2R23_RS32725	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E2R23_RS32730	COG0497	DNA recombination
E2R23_RS32735	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E2R23_RS32740	COG3164	Protein of unknown function
E2R23_RS32745	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E2R23_RS32750	COG0312	modulator of DNA gyrase
E2R23_RS32760	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E2R23_RS32770	COG1017	nitric oxide dioxygenase activity
E2R23_RS32770	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2R23_RS32775	COG2096	Adenosyltransferase
E2R23_RS32780	COG0277	FAD linked oxidase domain protein
E2R23_RS32785	COG0277	FAD linked oxidase domain protein
E2R23_RS32790	COG0277	FAD linked oxidase domain protein
E2R23_RS32795	COG0247	lactate metabolic process
E2R23_RS32815	COG3639	organic phosphonate transmembrane transporter activity
E2R23_RS32820	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E2R23_RS32825	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E2R23_RS32830	COG3454	Phosphonate metabolism
E2R23_RS32835	COG4778	phosphonate C-P lyase system protein PhnL
E2R23_RS32840	COG4107	phosphonate C-P lyase system protein PhnK
E2R23_RS32845	COG3627	carbon phosphorus lyase activity
E2R23_RS32850	COG3626	phosphonate metabolism
E2R23_RS32860	COG3624	Phosphonate C-P lyase system protein PhnG
E2R23_RS32870	COG2188	Transcriptional regulator
E2R23_RS32875	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E2R23_RS32880	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E2R23_RS32900	COG0783	Belongs to the Dps family
E2R23_RS32925	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E2R23_RS32940	COG0343	queuine tRNA-ribosyltransferase activity
E2R23_RS32950	COG1862	Preprotein translocase
E2R23_RS32955	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E2R23_RS32960	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E2R23_RS32975	COG2353	YceI-like domain
E2R23_RS32980	COG2353	YceI-like domain
E2R23_RS33000	COG2995	paraquat-inducible protein a
E2R23_RS33005	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E2R23_RS33005	COG3008	intermembrane lipid transfer
E2R23_RS33090	COG0069	glutamate synthase activity
E2R23_RS33095	COG0625	glutathione transferase activity
E2R23_RS33105	COG0006	proline dipeptidase activity
E2R23_RS33110	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2R23_RS33115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E2R23_RS33120	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E2R23_RS33160	COG0588	phosphoglycerate mutase activity
E2R23_RS33170	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E2R23_RS33185	COG0625	glutathione transferase activity
E2R23_RS33190	COG0625	glutathione transferase activity
E2R23_RS33195	COG4977	sequence-specific DNA binding
E2R23_RS33195	COG1917	Cupin 2, conserved barrel domain protein
E2R23_RS33235	COG0418	dihydroorotase activity
E2R23_RS33245	COG0121	glutamine amidotransferase
E2R23_RS33295	COG1126	abc transporter atp-binding protein
E2R23_RS33300	COG0765	amino acid transport
E2R23_RS33305	COG0765	amino acid transport
E2R23_RS33310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E2R23_RS33315	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E2R23_RS33325	COG0583	DNA-binding transcription factor activity
E2R23_RS33330	COG2223	nitrite transmembrane transporter activity
E2R23_RS33350	COG0800	Aldolase
E2R23_RS33365	COG1737	Transcriptional regulator
E2R23_RS33375	COG1981	membrane
E2R23_RS33380	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E2R23_RS33385	COG1466	dna polymerase III delta subunit
E2R23_RS33415	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E2R23_RS33420	COG0735	belongs to the Fur family
E2R23_RS33425	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E2R23_RS33430	COG4266	Belongs to the allantoicase family
E2R23_RS33435	COG1301	dicarboxylic acid transport
E2R23_RS33450	COG0583	DNA-binding transcription factor activity
E2R23_RS33465	COG2814	Major facilitator Superfamily
E2R23_RS33475	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E2R23_RS33480	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E2R23_RS33485	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E2R23_RS33495	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E2R23_RS33525	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E2R23_RS33530	COG1546	Belongs to the CinA family
E2R23_RS33535	COG0284	orotidine-5'-phosphate decarboxylase activity
E2R23_RS33545	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS33550	COG1172	Belongs to the binding-protein-dependent transport system permease family
E2R23_RS33565	COG1028	Short-chain dehydrogenase reductase Sdr
E2R23_RS33575	COG3734	2-keto-3-deoxy-galactonokinase
E2R23_RS33580	COG1414	Transcriptional regulator
E2R23_RS33600	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E2R23_RS33605	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E2R23_RS33610	COG0557	exoribonuclease II activity
E2R23_RS33615	COG3150	esterase
E2R23_RS33620	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E2R23_RS33630	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E2R23_RS33635	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E2R23_RS33640	COG0511	ligase activity, forming carbon-carbon bonds
E2R23_RS33645	COG0439	Biotin carboxylase
E2R23_RS33650	COG2264	protein methyltransferase activity
E2R23_RS33660	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E2R23_RS33665	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E2R23_RS33720	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E2R23_RS33725	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E2R23_RS33730	COG2095	MarC family integral membrane protein
E2R23_RS33780	COG0142	geranyltranstransferase activity
E2R23_RS33790	COG4536	flavin adenine dinucleotide binding
E2R23_RS33795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E2R23_RS33805	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
E2R23_RS33820	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E2R23_RS33825	COG0494	nUDIX hydrolase
E2R23_RS33835	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E2R23_RS33860	COG0678	peroxiredoxin activity
E2R23_RS33880	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E2R23_RS33915	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E2R23_RS33920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E2R23_RS33930	COG3116	cell division
E2R23_RS33950	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E2R23_RS33955	COG0318	PFAM AMP-dependent synthetase and ligase
E2R23_RS33960	COG0243	molybdopterin cofactor binding
E2R23_RS34010	COG1024	Enoyl-CoA hydratase
E2R23_RS34020	COG0183	Belongs to the thiolase family
E2R23_RS34025	COG1024	Enoyl-CoA hydratase
E2R23_RS34030	COG2050	protein possibly involved in aromatic compounds catabolism
E2R23_RS34040	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E2R23_RS34050	COG2967	ApaG domain
E2R23_RS34060	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E2R23_RS34065	COG0546	phosphoglycolate phosphatase activity
E2R23_RS34080	COG0512	Glutamine amidotransferase of anthranilate synthase
E2R23_RS34100	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E2R23_RS34115	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E2R23_RS34120	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E2R23_RS34150	COG0012	GTP binding
E2R23_RS34195	COG0584	glycerophosphoryl diester phosphodiesterase
E2R23_RS34210	COG0488	(ABC) transporter
E2R23_RS34225	COG1335	isochorismatase
E2R23_RS34230	COG0006	proline dipeptidase activity
E2R23_RS34260	COG2890	protein-(glutamine-N5) methyltransferase activity
E2R23_RS34265	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E2R23_RS34275	COG3384	dioxygenase
E2R23_RS34280	COG0531	amino acid
E2R23_RS34285	COG1278	Cold shock
E2R23_RS34295	COG0443	Heat shock 70 kDa protein
E2R23_RS34375	COG0308	aminopeptidase N
E2R23_RS34540	COG2969	positive regulation of protein catabolic process
E2R23_RS34545	COG0625	glutathione transferase activity
E2R23_RS34550	COG2857	Cytochrome c1
E2R23_RS34555	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E2R23_RS34560	COG0723	plastoquinol--plastocyanin reductase activity
E2R23_RS34565	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E2R23_RS34570	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E2R23_RS34575	COG0805	protein transport
E2R23_RS34625	COG2095	MarC family integral membrane protein
E2R23_RS34635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E2R23_RS34660	COG0842	Transport permease protein
E2R23_RS34665	COG1131	(ABC) transporter
E2R23_RS34690	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E2R23_RS34695	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E2R23_RS34700	COG1127	ABC transporter
E2R23_RS34725	COG4178	(ABC) transporter
E2R23_RS34740	COG1115	amino acid carrier protein
E2R23_RS34755	COG0069	glutamate synthase activity
E2R23_RS34755	COG0070	glutamate synthase
E2R23_RS34755	COG0067	glutamate synthase
E2R23_RS34770	COG0584	glycerophosphoryl diester phosphodiesterase
E2R23_RS34775	COG3842	ATPase activity
E2R23_RS34780	COG0395	ABC-type sugar transport system, permease component
E2R23_RS34785	COG1175	transmembrane transport
E2R23_RS34795	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E2R23_RS34850	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E2R23_RS34855	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E2R23_RS34860	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E2R23_RS34865	COG1333	cytochrome c biogenesis protein
E2R23_RS34885	COG4232	protein-disulfide reductase activity
E2R23_RS34930	COG0201	protein transport
E2R23_RS35065	COG0514	ATP-dependent DNA helicase (RecQ)
E2R23_RS35105	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E2R23_RS35190	COG3396	Phenylacetate-CoA oxygenase
E2R23_RS35195	COG3460	Phenylacetate-CoA oxygenase
E2R23_RS35200	COG3396	Phenylacetate-CoA oxygenase
E2R23_RS35205	COG2151	metal-sulfur cluster biosynthetic enzyme
E2R23_RS35210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E2R23_RS35230	COG1522	sequence-specific DNA binding
E2R23_RS35260	COG0280	phosphate acetyltransferase
E2R23_RS35260	COG0281	malic enzyme
E2R23_RS35270	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E2R23_RS35275	COG1881	PFAM PEBP family protein
E2R23_RS35290	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E2R23_RS35310	COG3047	cAMP biosynthetic process
E2R23_RS35315	COG0583	DNA-binding transcription factor activity
E2R23_RS35320	COG2814	Major facilitator Superfamily
E2R23_RS35325	COG1280	lysine exporter protein (LysE YggA)
E2R23_RS35330	COG2084	Dehydrogenase
E2R23_RS35375	COG1113	amino acid transport
E2R23_RS35395	COG2823	Periplasmic or secreted lipoprotein
E2R23_RS35400	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E2R23_RS35425	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E2R23_RS35435	COG1522	sequence-specific DNA binding
E2R23_RS35440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E2R23_RS35475	COG2070	2-Nitropropane dioxygenase
E2R23_RS35495	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E2R23_RS35500	COG1950	PFAM Membrane protein of
E2R23_RS35525	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E2R23_RS35530	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E2R23_RS35550	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E2R23_RS35555	COG0745	RESPONSE REGULATOR receiver
E2R23_RS35565	COG2201	protein-glutamate methylesterase activity
E2R23_RS35575	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E2R23_RS35595	COG2201	protein-glutamate methylesterase activity
E2R23_RS35600	COG1360	Flagellar Motor Protein
E2R23_RS35625	COG0438	transferase activity, transferring glycosyl groups
E2R23_RS35640	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E2R23_RS35645	COG0561	phosphatase activity
E2R23_RS35655	COG0519	Catalyzes the synthesis of GMP from XMP
E2R23_RS35735	COG2267	carboxylic ester hydrolase activity
E2R23_RS35760	COG3397	chitin binding
E2R23_RS35780	COG3245	cytochrome
E2R23_RS35785	COG0210	DNA helicase
E2R23_RS35805	COG0673	inositol 2-dehydrogenase activity
E2R23_RS35820	COG0509	glycine decarboxylation via glycine cleavage system
E2R23_RS35840	COG1760	l-serine dehydratase
E2R23_RS35870	COG1012	belongs to the aldehyde dehydrogenase family
E2R23_RS35880	COG4302	ethanolamine ammonia-lyase activity
E2R23_RS35885	COG4303	Ethanolamine ammonia lyase large subunit
E2R23_RS35890	COG0531	amino acid
E2R23_RS35910	COG0668	transmembrane transport
E2R23_RS35930	COG0789	Transcriptional regulator
E2R23_RS35940	COG0277	FAD linked oxidase domain protein
E2R23_RS35955	COG0436	Aminotransferase
E2R23_RS35975	COG1960	acyl-CoA dehydrogenase activity
E2R23_RS35990	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E2R23_RS35990	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E2R23_RS35990	COG0506	proline dehydrogenase activity
E2R23_RS36010	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E2R23_RS36030	COG1832	CoA-binding protein
E2R23_RS36050	COG0318	PFAM AMP-dependent synthetase and ligase
E2R23_RS36090	COG0356	it plays a direct role in the translocation of protons across the membrane
E2R23_RS36105	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E2R23_RS36110	COG1475	DNA binding
E2R23_RS36115	COG1192	Involved in chromosome partitioning
E2R23_RS36160	COG0559	Belongs to the binding-protein-dependent transport system permease family
E2R23_RS36190	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E2R23_RS36205	COG0583	DNA-binding transcription factor activity
E2R23_RS36220	COG1522	sequence-specific DNA binding
E2R23_RS36225	COG3186	Phenylalanine-4-hydroxylase
E2R23_RS36245	COG0642	Histidine kinase
E2R23_RS36265	COG1902	pentaerythritol trinitrate reductase activity
E2R23_RS36270	COG0519	Catalyzes the synthesis of GMP from XMP
E2R23_RS36270	COG0518	GMP synthase (glutamine-hydrolyzing) activity