locus-tag	class	description
X993_RS00015	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
X993_RS00040	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
X993_RS00045	COG4774	siderophore transport
X993_RS00050	COG3486	L-lysine 6-monooxygenase (NADPH) activity
X993_RS00090	COG1120	ATPase activity
X993_RS00115	COG1028	Short-chain dehydrogenase reductase Sdr
X993_RS00120	COG1070	Carbohydrate kinase
X993_RS00125	COG1063	alcohol dehydrogenase
X993_RS00130	COG1172	Belongs to the binding-protein-dependent transport system permease family
X993_RS00140	COG1879	ABC-type sugar transport system periplasmic component
X993_RS00160	COG2375	cellular response to nickel ion
X993_RS00160	COG1132	(ABC) transporter
X993_RS00170	COG3121	Chaperone
X993_RS00180	COG3539	Fimbrial protein
X993_RS00195	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
X993_RS00205	COG1309	transcriptional regulator
X993_RS00210	COG0739	heme binding
X993_RS00215	COG0765	amino acid transport
X993_RS00220	COG4597	amino acid ABC transporter
X993_RS00235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X993_RS00280	COG4964	Belongs to the GSP D family
X993_RS00300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
X993_RS00305	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
X993_RS00320	COG0477	Major facilitator Superfamily
X993_RS00325	COG2719	SpoVR family
X993_RS00330	COG2718	Belongs to the UPF0229 family
X993_RS00335	COG2766	serine protein kinase
X993_RS00340	COG0840	transmembrane signaling receptor activity
X993_RS00345	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X993_RS00350	COG1609	Transcriptional regulator
X993_RS00355	COG1172	Belongs to the binding-protein-dependent transport system permease family
X993_RS00360	COG1129	ABC transporter
X993_RS00365	COG1879	ABC-type sugar transport system periplasmic component
X993_RS00370	COG0583	DNA-binding transcription factor activity
X993_RS00375	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
X993_RS00380	COG4208	sulfate ABC transporter
X993_RS00385	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
X993_RS00390	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
X993_RS00430	COG0701	Predicted permease
X993_RS00435	COG0667	Aldo Keto reductase
X993_RS00460	COG1301	dicarboxylic acid transport
X993_RS00490	COG1116	anion transmembrane transporter activity
X993_RS00495	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
X993_RS00545	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
X993_RS00555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X993_RS00560	COG0765	amino acid transport
X993_RS00575	COG1802	Transcriptional regulator
X993_RS00585	COG3023	N-Acetylmuramoyl-L-alanine amidase
X993_RS00595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
X993_RS00600	COG0557	exoribonuclease II activity
X993_RS00615	COG0840	transmembrane signaling receptor activity
X993_RS00640	COG0519	Catalyzes the synthesis of GMP from XMP
X993_RS00645	COG2814	Major facilitator Superfamily
X993_RS00655	COG0318	PFAM AMP-dependent synthetase and ligase
X993_RS00720	COG4964	Belongs to the GSP D family
X993_RS00775	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
X993_RS00780	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
X993_RS00785	COG0508	dehydrogenase complex catalyzes the overall conversion of
X993_RS00790	COG0567	Dehydrogenase, E1 component
X993_RS00795	COG1217	gtp-binding protein TYPA
X993_RS00800	COG1846	Transcriptional regulator
X993_RS00810	COG1566	PFAM secretion protein HlyD family protein
X993_RS00815	COG2814	Major facilitator Superfamily
X993_RS00820	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
X993_RS00835	COG2251	uridine kinase activity
X993_RS00835	COG0195	Participates in both transcription termination and antitermination
X993_RS00845	COG1187	pseudouridine synthase activity
X993_RS00850	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
X993_RS00855	COG0583	DNA-binding transcription factor activity
X993_RS00895	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
X993_RS00915	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
X993_RS00915	COG2755	lipolytic protein G-D-S-L family
X993_RS00930	COG0776	regulation of translation
X993_RS00955	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
X993_RS00970	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
X993_RS00975	COG0251	oxidation-reduction process
X993_RS00980	COG2267	carboxylic ester hydrolase activity
X993_RS00990	COG0583	DNA-binding transcription factor activity
X993_RS01005	COG1028	Short-chain dehydrogenase reductase Sdr
X993_RS01040	COG1028	Short-chain dehydrogenase reductase Sdr
X993_RS01055	COG2801	Transposase and inactivated derivatives
X993_RS01070	COG0477	Major facilitator Superfamily
X993_RS01085	COG1295	ribonuclease BN
X993_RS01100	COG0277	FAD linked oxidase domain protein
X993_RS01115	COG0583	DNA-binding transcription factor activity
X993_RS01140	COG0840	transmembrane signaling receptor activity
X993_RS01145	COG2223	nitrite transmembrane transporter activity
X993_RS01150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
X993_RS01155	COG0210	DNA helicase
X993_RS01160	COG0525	valine-tRNA ligase activity
X993_RS01165	COG1210	Utp--glucose-1-phosphate uridylyltransferase
X993_RS01175	COG5002	protein histidine kinase activity
X993_RS01185	COG0745	RESPONSE REGULATOR receiver
X993_RS01195	COG0425	Belongs to the sulfur carrier protein TusA family
X993_RS01200	COG0673	inositol 2-dehydrogenase activity
X993_RS01205	COG0673	inositol 2-dehydrogenase activity
X993_RS01220	COG1172	Belongs to the binding-protein-dependent transport system permease family
X993_RS01235	COG3962	Belongs to the TPP enzyme family
X993_RS01245	COG3718	enzyme involved in inositol metabolism
X993_RS01255	COG0411	ABC transporter
X993_RS01265	COG0824	Thioesterase
X993_RS01280	COG2816	NAD+ diphosphatase activity
X993_RS01290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X993_RS01295	COG0477	Major facilitator Superfamily
X993_RS01310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
X993_RS01320	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
X993_RS01325	COG0494	nUDIX hydrolase
X993_RS01345	COG1858	cytochrome C peroxidase
X993_RS01350	COG3511	phospholipase C
X993_RS01360	COG1566	PFAM secretion protein HlyD family protein
X993_RS01365	COG2814	Major facilitator Superfamily
X993_RS01370	COG1538	Outer membrane efflux protein
X993_RS01375	COG2197	response regulator
X993_RS01415	COG0583	DNA-binding transcription factor activity
X993_RS01420	COG2814	Major facilitator Superfamily
X993_RS01445	COG1914	H( )-stimulated, divalent metal cation uptake system
X993_RS01450	COG2963	transposase activity
X993_RS01455	COG2801	Transposase and inactivated derivatives
X993_RS01460	COG3328	transposase activity
X993_RS01620	COG0457	Tetratricopeptide repeat
X993_RS01620	COG0859	PFAM glycosyl transferase family 9
X993_RS01665	COG0745	RESPONSE REGULATOR receiver
X993_RS01670	COG0583	DNA-binding transcription factor activity
X993_RS01705	COG0366	Alpha amylase catalytic
X993_RS01710	COG0366	Alpha amylase catalytic
X993_RS01755	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
X993_RS01785	COG0582	viral genome integration into host DNA
X993_RS01810	COG4942	peptidase
X993_RS01815	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
X993_RS01825	COG0534	Mate efflux family protein
X993_RS01890	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
X993_RS01900	COG0745	RESPONSE REGULATOR receiver
X993_RS01915	COG0581	inorganic phosphate transmembrane transporter activity
X993_RS01920	COG0573	inorganic phosphate transmembrane transporter activity
X993_RS01925	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
X993_RS01935	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
X993_RS01940	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
X993_RS01950	COG1534	Rna-binding protein
X993_RS01960	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
X993_RS01965	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
X993_RS01975	COG0505	Belongs to the CarA family
X993_RS01995	COG1388	LysM domain
X993_RS01995	COG0741	lytic transglycosylase activity
X993_RS02000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X993_RS02005	COG2226	methyltransferase
X993_RS02010	COG0328	RNA-DNA hybrid ribonuclease activity
X993_RS02015	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
X993_RS02025	COG0477	Major facilitator Superfamily
X993_RS02050	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
X993_RS02060	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
X993_RS02080	COG3052	prosthetic group binding
X993_RS02105	COG0583	DNA-binding transcription factor activity
X993_RS02115	COG1250	3-hydroxyacyl-CoA dehydrogenase
X993_RS02120	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
X993_RS02155	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X993_RS02185	COG0583	DNA-binding transcription factor activity
X993_RS02205	COG1522	sequence-specific DNA binding
X993_RS02255	COG0582	viral genome integration into host DNA
X993_RS02290	COG1484	DNA-dependent DNA replication
X993_RS02355	COG2801	Transposase and inactivated derivatives
X993_RS02370	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X993_RS02405	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
X993_RS02450	COG3193	protein, possibly involved in utilization of glycolate and propanediol
X993_RS02460	COG0672	)-iron permease
X993_RS02465	COG4633	Protein conserved in bacteria
X993_RS02475	COG0556	nucleotide-excision repair
X993_RS02485	COG1028	Short-chain dehydrogenase reductase Sdr
X993_RS02490	COG0667	Aldo Keto reductase
X993_RS02495	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
X993_RS02505	COG0789	Transcriptional regulator
X993_RS02555	COG2866	Carboxypeptidase
X993_RS02570	COG0436	Aminotransferase
X993_RS02580	COG1024	Enoyl-CoA hydratase
X993_RS02585	COG0588	phosphoglycerate mutase activity
X993_RS02595	COG1960	acyl-CoA dehydrogenase activity
X993_RS02615	COG2030	dehydratase
X993_RS02615	COG1012	belongs to the aldehyde dehydrogenase family
X993_RS02620	COG1960	acyl-CoA dehydrogenase activity
X993_RS02625	COG1960	acyl-CoA dehydrogenase activity
X993_RS02645	COG1007	ATP synthesis coupled electron transport
X993_RS02680	COG1034	ATP synthesis coupled electron transport
X993_RS02690	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
X993_RS02725	COG0149	triose-phosphate isomerase activity
X993_RS02730	COG0604	alcohol dehydrogenase
X993_RS02730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
X993_RS02730	COG4221	oxidoreductase activity
X993_RS02730	COG3321	synthase
X993_RS02745	COG0683	leucine binding
X993_RS02760	COG0288	reversible hydration of carbon dioxide
X993_RS02765	COG0659	secondary active sulfate transmembrane transporter activity
X993_RS02775	COG1183	phosphatidylcholine synthase activity
X993_RS02795	COG0028	Belongs to the TPP enzyme family
X993_RS02825	COG0438	transferase activity, transferring glycosyl groups
X993_RS02845	COG1028	Short-chain dehydrogenase reductase Sdr
X993_RS02850	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
X993_RS02860	COG0154	amidase activity
X993_RS02870	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
X993_RS02900	COG0745	RESPONSE REGULATOR receiver
X993_RS02905	COG2205	protein histidine kinase activity
X993_RS02920	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
X993_RS02925	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
X993_RS02945	COG1028	Short-chain dehydrogenase reductase Sdr
X993_RS02960	COG0151	Belongs to the GarS family
X993_RS02975	COG0799	negative regulation of ribosome biogenesis
X993_RS02995	COG2233	PERMEase
X993_RS03030	COG1595	DNA-templated transcription, initiation
X993_RS03035	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
X993_RS03065	COG0859	PFAM glycosyl transferase family 9
X993_RS03070	COG0438	transferase activity, transferring glycosyl groups
X993_RS03110	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
X993_RS03115	COG0513	Belongs to the DEAD box helicase family
X993_RS03150	COG1674	ftsk spoiiie
X993_RS03155	COG2706	6-phosphogluconolactonase activity
X993_RS03160	COG3387	PFAM Glycoside hydrolase 15-related
X993_RS03170	COG1309	transcriptional regulator
X993_RS03175	COG2878	Part of a membrane complex involved in electron transport
X993_RS03180	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
X993_RS03215	COG3135	benzoate transporter
X993_RS03225	COG2764	glyoxalase bleomycin resistance protein dioxygenase
X993_RS03260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X993_RS03270	COG0697	spore germination
X993_RS03275	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X993_RS03315	COG0477	Major facilitator Superfamily
X993_RS03320	COG0583	DNA-binding transcription factor activity
X993_RS03330	COG0583	DNA-binding transcription factor activity
X993_RS03360	COG0488	(ABC) transporter
X993_RS03370	COG1773	rubredoxin
X993_RS03450	COG1881	PFAM PEBP family protein
X993_RS03455	COG2814	Major facilitator Superfamily
X993_RS03475	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
X993_RS03495	COG2801	Transposase and inactivated derivatives
X993_RS03545	COG2192	nodulation
X993_RS03550	COG0812	UDP-N-acetylmuramate dehydrogenase activity
X993_RS03570	COG0582	viral genome integration into host DNA
X993_RS03575	COG1116	anion transmembrane transporter activity
X993_RS03580	COG1176	ABC-type spermidine putrescine transport system, permease component I
X993_RS03605	COG1741	Belongs to the pirin family
X993_RS03620	COG4215	(ABC) transporter
X993_RS03640	COG0347	Belongs to the P(II) protein family
X993_RS03655	COG1472	Belongs to the glycosyl hydrolase 3 family
X993_RS03665	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
X993_RS03680	COG2271	Major facilitator Superfamily
X993_RS03710	COG2226	methyltransferase
X993_RS03745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
X993_RS03770	COG0489	protein tyrosine kinase activity
X993_RS03775	COG2885	chlorophyll binding
X993_RS03775	COG3047	cAMP biosynthetic process
X993_RS03795	COG2911	Protein conserved in bacteria
X993_RS03800	COG0729	surface antigen
X993_RS03810	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
X993_RS03825	COG0489	protein tyrosine kinase activity
X993_RS03830	COG2259	Doxx family
X993_RS03845	COG1492	cobalamin metabolic process
X993_RS03855	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
X993_RS03865	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
X993_RS03880	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
X993_RS03885	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
X993_RS03890	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
X993_RS03900	COG4206	TonB-dependent receptor
X993_RS03930	COG0583	DNA-binding transcription factor activity
X993_RS03940	COG4654	Cytochrome c, class I
X993_RS03960	COG0795	lipopolysaccharide-transporting ATPase activity
X993_RS03975	COG1648	precorrin-2 dehydrogenase activity
X993_RS03975	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
X993_RS03980	COG2895	sulfate adenylyltransferase (ATP) activity
X993_RS03990	COG0175	sulfate reduction
X993_RS04005	COG0583	DNA-binding transcription factor activity
X993_RS04020	COG1396	sequence-specific DNA binding
X993_RS04030	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
X993_RS04035	COG2258	MOSC domain
X993_RS04040	COG2267	carboxylic ester hydrolase activity
X993_RS04050	COG0583	DNA-binding transcription factor activity
X993_RS04060	COG1187	pseudouridine synthase activity
X993_RS04075	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
X993_RS04075	COG0543	2 iron, 2 sulfur cluster binding
X993_RS04080	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
X993_RS04085	COG0456	acetyltransferase
X993_RS04120	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
X993_RS04125	COG1047	Peptidyl-prolyl cis-trans
X993_RS04145	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
X993_RS04165	COG3264	Mechanosensitive ion channel
X993_RS04165	COG1511	domain protein
X993_RS04170	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
X993_RS04170	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
X993_RS04175	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
X993_RS04180	COG0196	riboflavin kinase activity
X993_RS04185	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
X993_RS04215	COG1113	amino acid transport
X993_RS04220	COG0542	response to heat
X993_RS04230	COG1278	Cold shock
X993_RS04235	COG2132	Multicopper oxidase
X993_RS04255	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
X993_RS04270	COG0656	L-ascorbic acid biosynthetic process
X993_RS04275	COG2188	Transcriptional regulator
X993_RS04295	COG2814	Major facilitator Superfamily
X993_RS04340	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
X993_RS04345	COG1570	exodeoxyribonuclease VII activity
X993_RS04350	COG1663	tetraacyldisaccharide 4'-kinase activity
X993_RS04380	COG0728	peptidoglycan biosynthetic process
X993_RS04395	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
X993_RS04415	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
X993_RS04420	COG0318	PFAM AMP-dependent synthetase and ligase
X993_RS04425	COG4974	Belongs to the 'phage' integrase family
X993_RS04435	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
X993_RS04440	COG0802	atpase or kinase
X993_RS04445	COG0860	N-Acetylmuramoyl-L-alanine amidase
X993_RS04455	COG1741	Belongs to the pirin family
X993_RS04460	COG3118	belongs to the thioredoxin family
X993_RS04470	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
X993_RS04480	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
X993_RS04495	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
X993_RS04505	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
X993_RS04510	COG1522	sequence-specific DNA binding
X993_RS04530	COG2271	Major facilitator Superfamily
X993_RS04540	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
X993_RS04545	COG1012	belongs to the aldehyde dehydrogenase family
X993_RS04555	COG0583	DNA-binding transcription factor activity
X993_RS04560	COG0246	Mannitol dehydrogenase
X993_RS04565	COG1070	Carbohydrate kinase
X993_RS04570	COG2390	Transcriptional regulator
X993_RS04585	COG0583	DNA-binding transcription factor activity
X993_RS04595	COG3842	ATPase activity
X993_RS04600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
X993_RS04610	COG1175	transmembrane transport
X993_RS04625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X993_RS04635	COG0735	belongs to the Fur family
X993_RS04645	COG1121	(ABC) transporter
X993_RS04650	COG1108	ABC-type Mn2 Zn2 transport systems permease components
X993_RS04655	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
X993_RS04670	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
X993_RS04675	COG2233	PERMEase
X993_RS04685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
X993_RS04690	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X993_RS04715	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X993_RS04750	COG0009	L-threonylcarbamoyladenylate synthase
X993_RS04755	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
X993_RS04760	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
X993_RS04765	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
X993_RS04775	COG0469	pyruvate kinase activity
X993_RS04780	COG0126	phosphoglycerate kinase activity
X993_RS04805	COG0859	PFAM glycosyl transferase family 9
X993_RS04815	COG0429	hydrolase of the alpha beta-hydrolase fold
X993_RS04825	COG4783	chaperone-mediated protein folding
X993_RS04845	COG3307	-O-antigen
X993_RS04850	COG4969	Belongs to the N-Me-Phe pilin family
X993_RS04855	COG0861	Integral membrane protein TerC family
X993_RS04860	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
X993_RS04875	COG2137	regulation of response to DNA damage stimulus
X993_RS04880	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
X993_RS04945	COG0784	Response regulator, receiver
X993_RS04945	COG5002	protein histidine kinase activity
X993_RS04950	COG0583	DNA-binding transcription factor activity
X993_RS04990	COG0028	Belongs to the TPP enzyme family
X993_RS04995	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
X993_RS05000	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
X993_RS05075	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
X993_RS05080	COG0583	DNA-binding transcription factor activity
X993_RS05100	COG0840	transmembrane signaling receptor activity
X993_RS05140	COG4948	Mandelate Racemase Muconate Lactonizing
X993_RS05160	COG0513	Belongs to the DEAD box helicase family
X993_RS05200	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
X993_RS05205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
X993_RS05215	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
X993_RS05220	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
X993_RS05225	COG0367	asparagine synthase
X993_RS05240	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
X993_RS05250	COG1396	sequence-specific DNA binding
X993_RS05255	COG2814	Major facilitator Superfamily
X993_RS05260	COG0583	DNA-binding transcription factor activity
X993_RS05270	COG1702	phosphate starvation-inducible protein PhoH
X993_RS05280	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
X993_RS05290	COG0815	Transfers the fatty acyl group on membrane lipoproteins
X993_RS05295	COG0752	glycyl-tRNA synthetase alpha subunit
X993_RS05300	COG0751	glycine-tRNA ligase activity
X993_RS05305	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
X993_RS05310	COG0204	Acyl-transferase
X993_RS05335	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
X993_RS05350	COG3178	'Phosphotransferase
X993_RS05355	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
X993_RS05365	COG5265	(ABC) transporter
X993_RS05380	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
X993_RS05385	COG1024	Enoyl-CoA hydratase
X993_RS05390	COG0183	Belongs to the thiolase family
X993_RS05395	COG1024	Enoyl-CoA hydratase
X993_RS05395	COG1250	3-hydroxyacyl-CoA dehydrogenase
X993_RS05400	COG1960	acyl-CoA dehydrogenase activity
X993_RS05415	COG0494	nUDIX hydrolase
X993_RS05480	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
X993_RS05490	COG0251	oxidation-reduction process
X993_RS05495	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
X993_RS05520	COG0477	Major facilitator Superfamily
X993_RS05555	COG1596	polysaccharide export
X993_RS05560	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
X993_RS05575	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
X993_RS05585	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
X993_RS05605	COG2204	response regulator
X993_RS05640	COG5001	Diguanylate cyclase
X993_RS05640	COG5002	protein histidine kinase activity
X993_RS05645	COG0235	Class ii aldolase
X993_RS05705	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
X993_RS05730	COG0629	single-stranded DNA binding
X993_RS05735	COG2814	Major facilitator Superfamily
X993_RS05760	COG1280	lysine exporter protein (LysE YggA)
X993_RS05780	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
X993_RS05795	COG1137	ATPase activity
X993_RS05800	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
X993_RS05805	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
X993_RS05830	COG1194	a g-specific adenine glycosylase
X993_RS05845	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
X993_RS05860	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
X993_RS05880	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
X993_RS05890	COG0742	ribosomal rna small subunit methyltransferase
X993_RS05900	COG0625	glutathione transferase activity
X993_RS05910	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
X993_RS05920	COG0243	molybdopterin cofactor binding
X993_RS05925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
X993_RS05935	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
X993_RS05945	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
X993_RS05950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
X993_RS05970	COG1294	oxidase, subunit
X993_RS05995	COG2190	(PTS) system
X993_RS05995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
X993_RS05995	COG1263	PTS System
X993_RS06000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
X993_RS06000	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
X993_RS06005	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
X993_RS06010	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
X993_RS06015	COG2188	Transcriptional regulator
X993_RS06020	COG0583	DNA-binding transcription factor activity
X993_RS06065	COG0318	PFAM AMP-dependent synthetase and ligase
X993_RS06075	COG1960	acyl-CoA dehydrogenase activity
X993_RS06085	COG2226	methyltransferase
X993_RS06120	COG2814	Major facilitator Superfamily
X993_RS06130	COG0587	DNA-directed DNA polymerase activity
X993_RS06145	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
X993_RS06165	COG0840	transmembrane signaling receptor activity
X993_RS06175	COG1999	signal sequence binding
X993_RS06185	COG1612	heme a metabolic process
X993_RS06215	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
X993_RS06225	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
X993_RS06240	COG2226	methyltransferase
X993_RS06245	COG1040	competence protein
X993_RS06255	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
X993_RS06275	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X993_RS06285	COG0793	Belongs to the peptidase S41A family
X993_RS06290	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
X993_RS06295	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
X993_RS06300	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
X993_RS06310	COG0189	ligase activity
X993_RS06320	COG0004	ammonium transporteR
X993_RS06330	COG2960	long-chain fatty acid transporting porin activity
X993_RS06360	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X993_RS06370	COG4191	Histidine kinase
X993_RS06380	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X993_RS06390	COG1804	L-carnitine dehydratase bile acid-inducible protein F
X993_RS06395	COG1960	acyl-CoA dehydrogenase activity
X993_RS06400	COG1960	acyl-CoA dehydrogenase activity
X993_RS06405	COG1250	3-hydroxyacyl-CoA dehydrogenase
X993_RS06405	COG1024	Enoyl-CoA hydratase
X993_RS06410	COG0583	DNA-binding transcription factor activity
X993_RS06455	COG0583	DNA-binding transcription factor activity
X993_RS06460	COG2921	Belongs to the UPF0250 family
X993_RS06470	COG1686	Belongs to the peptidase S11 family
X993_RS06505	COG1127	ABC transporter
X993_RS06510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
X993_RS06515	COG0737	Belongs to the 5'-nucleotidase family
X993_RS06530	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
X993_RS06540	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
X993_RS06560	COG1024	Enoyl-CoA hydratase
X993_RS06610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
X993_RS06615	COG4221	oxidoreductase activity
X993_RS06620	COG1028	Short-chain dehydrogenase reductase Sdr
X993_RS06635	COG0747	negative chemotaxis
X993_RS06640	COG0488	(ABC) transporter
X993_RS06655	COG0288	reversible hydration of carbon dioxide
X993_RS06660	COG0183	Belongs to the thiolase family
X993_RS06670	COG3012	SEC-C Motif Domain Protein
X993_RS06715	COG1785	Belongs to the alkaline phosphatase family
X993_RS06725	COG2200	EAL domain
X993_RS06725	COG2199	diguanylate cyclase activity
X993_RS06730	COG0025	NhaP-type Na H and K H
X993_RS06770	COG2204	response regulator
X993_RS06800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
X993_RS06815	COG1999	signal sequence binding
X993_RS06850	COG3511	phospholipase C
X993_RS06870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
X993_RS06900	COG0596	Alpha beta hydrolase
X993_RS06910	COG0583	DNA-binding transcription factor activity
X993_RS06915	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
X993_RS06940	COG0840	transmembrane signaling receptor activity
X993_RS06945	COG1609	Transcriptional regulator
X993_RS06995	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
X993_RS07015	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
X993_RS07020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X993_RS07040	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
X993_RS07045	COG1704	LemA family
X993_RS07125	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
X993_RS07135	COG2824	Alkylphosphonate utilization operon protein PhnA
X993_RS07155	COG0583	DNA-binding transcription factor activity
X993_RS07160	COG2233	PERMEase
X993_RS07165	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
X993_RS07175	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
X993_RS07185	COG1706	bacterial-type flagellum-dependent cell motility
X993_RS07190	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
X993_RS07205	COG1749	Flagellar hook protein flgE
X993_RS07210	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
X993_RS07215	COG1558	bacterial-type flagellum-dependent cell motility
X993_RS07220	COG1815	bacterial-type flagellum-dependent cell motility
X993_RS07230	COG2747	anti-sigma28 factor FlgM
X993_RS07300	COG2207	Transcriptional regulator
X993_RS07330	COG0741	lytic transglycosylase activity
X993_RS07335	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
X993_RS07350	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
X993_RS07355	COG1984	allophanate hydrolase subunit 2
X993_RS07385	COG4608	Belongs to the ABC transporter superfamily
X993_RS07390	COG0444	Belongs to the ABC transporter superfamily
X993_RS07395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X993_RS07400	COG0601	transmembrane transport
X993_RS07405	COG0747	negative chemotaxis
X993_RS07420	COG0579	oxidoreductase
X993_RS07440	COG3568	Endonuclease Exonuclease Phosphatase
X993_RS07445	COG1280	lysine exporter protein (LysE YggA)
X993_RS07465	COG0531	amino acid
X993_RS07480	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
X993_RS07540	COG1960	acyl-CoA dehydrogenase activity
X993_RS07555	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
X993_RS07565	COG2814	Major facilitator Superfamily
X993_RS07580	COG0667	Aldo Keto reductase
X993_RS07605	COG1560	Kdo2-lipid A biosynthetic process
X993_RS07620	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
X993_RS07630	COG0523	cobalamin synthesis protein
X993_RS07655	COG2801	Transposase and inactivated derivatives
X993_RS07660	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
X993_RS07685	COG1309	transcriptional regulator
X993_RS07700	COG2814	Major facilitator Superfamily
X993_RS07710	COG2207	Transcriptional regulator
X993_RS07715	COG1064	alcohol dehydrogenase
X993_RS07720	COG0708	Exodeoxyribonuclease III
X993_RS07725	COG2326	polyphosphate kinase activity
X993_RS07745	COG1077	Cell shape determining protein MreB Mrl
X993_RS07760	COG0768	penicillin binding
X993_RS07765	COG0772	Belongs to the SEDS family
X993_RS07785	COG0720	synthase
X993_RS07790	COG0602	queuosine metabolic process
X993_RS07805	COG2204	response regulator
X993_RS07810	COG5000	phosphorelay sensor kinase activity
X993_RS07820	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
X993_RS07820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
X993_RS07840	COG0242	peptide deformylase activity
X993_RS07845	COG0758	DNA mediated transformation
X993_RS07860	COG0583	DNA-binding transcription factor activity
X993_RS07865	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X993_RS07900	COG4695	Portal protein
X993_RS07910	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
X993_RS07925	COG0583	DNA-binding transcription factor activity
X993_RS07945	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
X993_RS07960	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
X993_RS07960	COG2169	Transcriptional regulator
X993_RS07980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
X993_RS08010	COG2963	transposase activity
X993_RS08015	COG2801	Transposase and inactivated derivatives
X993_RS08085	COG0582	viral genome integration into host DNA
X993_RS08125	COG0592	DNA-directed DNA polymerase activity
X993_RS08140	COG2963	transposase activity
X993_RS08155	COG0753	catalase activity
X993_RS08195	COG1804	L-carnitine dehydratase bile acid-inducible protein F
X993_RS08200	COG1250	3-hydroxyacyl-CoA dehydrogenase
X993_RS08200	COG1024	Enoyl-CoA hydratase
X993_RS08205	COG0183	Belongs to the thiolase family
X993_RS08215	COG1960	acyl-CoA dehydrogenase activity
X993_RS08240	COG1695	Transcriptional regulator
X993_RS08300	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
X993_RS08315	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
X993_RS08330	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
X993_RS08340	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
X993_RS08355	COG0789	Transcriptional regulator
X993_RS08365	COG1987	bacterial-type flagellum assembly
X993_RS08380	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
X993_RS08400	COG1346	cytolysis
X993_RS08410	COG0583	DNA-binding transcription factor activity
X993_RS08415	COG2814	Major facilitator Superfamily
X993_RS08420	COG1846	Transcriptional regulator
X993_RS08465	COG2165	general secretion pathway protein
X993_RS08480	COG1459	type II secretion system
X993_RS08500	COG0523	cobalamin synthesis protein
X993_RS08510	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
X993_RS08510	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X993_RS08530	COG0519	Catalyzes the synthesis of GMP from XMP
X993_RS08530	COG0518	GMP synthase (glutamine-hydrolyzing) activity
X993_RS08535	COG1902	pentaerythritol trinitrate reductase activity
X993_RS08550	COG0642	Histidine kinase
X993_RS08575	COG1522	sequence-specific DNA binding
X993_RS08585	COG0583	DNA-binding transcription factor activity
X993_RS08595	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
X993_RS08615	COG0559	Belongs to the binding-protein-dependent transport system permease family
X993_RS08660	COG1192	Involved in chromosome partitioning
X993_RS08665	COG1475	DNA binding
X993_RS08670	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
X993_RS08680	COG0356	it plays a direct role in the translocation of protons across the membrane
X993_RS08720	COG0318	PFAM AMP-dependent synthetase and ligase
X993_RS08725	COG1832	CoA-binding protein
X993_RS08740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
X993_RS08750	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
X993_RS08750	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
X993_RS08750	COG0506	proline dehydrogenase activity
X993_RS08765	COG1960	acyl-CoA dehydrogenase activity
X993_RS08785	COG0436	Aminotransferase
X993_RS08800	COG0277	FAD linked oxidase domain protein
X993_RS08810	COG0789	Transcriptional regulator
X993_RS08830	COG0668	transmembrane transport
X993_RS08845	COG0531	amino acid
X993_RS08850	COG4303	Ethanolamine ammonia lyase large subunit
X993_RS08855	COG4302	ethanolamine ammonia-lyase activity
X993_RS08865	COG1012	belongs to the aldehyde dehydrogenase family
X993_RS08890	COG1760	l-serine dehydratase
X993_RS08905	COG0509	glycine decarboxylation via glycine cleavage system
X993_RS08920	COG0673	inositol 2-dehydrogenase activity
X993_RS08935	COG0210	DNA helicase
X993_RS08940	COG3245	cytochrome
X993_RS08955	COG3311	Transcriptional regulator
X993_RS09045	COG5377	YqaJ viral recombinase family
X993_RS09070	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
X993_RS09090	COG3547	Transposase (IS116 IS110 IS902 family)
X993_RS09160	COG2801	Transposase and inactivated derivatives
X993_RS09165	COG2963	transposase activity
X993_RS09170	COG0582	viral genome integration into host DNA
X993_RS09195	COG3397	chitin binding
X993_RS09215	COG2267	carboxylic ester hydrolase activity
X993_RS09275	COG1028	Short-chain dehydrogenase reductase Sdr
X993_RS09290	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
X993_RS09325	COG0519	Catalyzes the synthesis of GMP from XMP
X993_RS09335	COG0561	phosphatase activity
X993_RS09340	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
X993_RS09350	COG0438	transferase activity, transferring glycosyl groups
X993_RS09375	COG2201	protein-glutamate methylesterase activity
X993_RS09395	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
X993_RS09405	COG2201	protein-glutamate methylesterase activity
X993_RS09410	COG0745	RESPONSE REGULATOR receiver
X993_RS09415	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
X993_RS09435	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
X993_RS09440	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
X993_RS09465	COG1950	PFAM Membrane protein of
X993_RS09470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
X993_RS09485	COG2070	2-Nitropropane dioxygenase
X993_RS09495	COG0738	Major facilitator superfamily
X993_RS09510	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
X993_RS09515	COG1522	sequence-specific DNA binding
X993_RS09525	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X993_RS09535	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
X993_RS09545	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
X993_RS09550	COG2823	Periplasmic or secreted lipoprotein
X993_RS09565	COG1113	amino acid transport
X993_RS09595	COG2084	Dehydrogenase
X993_RS09600	COG1280	lysine exporter protein (LysE YggA)
X993_RS09605	COG2814	Major facilitator Superfamily
X993_RS09610	COG0583	DNA-binding transcription factor activity
X993_RS09620	COG3047	cAMP biosynthetic process
X993_RS09635	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
X993_RS09645	COG1881	PFAM PEBP family protein
X993_RS09650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
X993_RS09655	COG0281	malic enzyme
X993_RS09655	COG0280	phosphate acetyltransferase
X993_RS09675	COG1522	sequence-specific DNA binding
X993_RS09695	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
X993_RS09700	COG2151	metal-sulfur cluster biosynthetic enzyme
X993_RS09705	COG3396	Phenylacetate-CoA oxygenase
X993_RS09710	COG3460	Phenylacetate-CoA oxygenase
X993_RS09715	COG3396	Phenylacetate-CoA oxygenase
X993_RS09775	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
X993_RS09815	COG0514	ATP-dependent DNA helicase (RecQ)
X993_RS09945	COG0201	protein transport
X993_RS09990	COG4232	protein-disulfide reductase activity
X993_RS10010	COG1333	cytochrome c biogenesis protein
X993_RS10015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
X993_RS10020	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
X993_RS10025	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
X993_RS10080	COG0232	Belongs to the dGTPase family. Type 2 subfamily
X993_RS10090	COG1175	transmembrane transport
X993_RS10095	COG0395	ABC-type sugar transport system, permease component
X993_RS10100	COG3842	ATPase activity
X993_RS10105	COG0584	glycerophosphoryl diester phosphodiesterase
X993_RS10120	COG0070	glutamate synthase
X993_RS10120	COG0069	glutamate synthase activity
X993_RS10120	COG0067	glutamate synthase
X993_RS10130	COG1115	amino acid carrier protein
X993_RS10140	COG4178	(ABC) transporter
X993_RS10165	COG1127	ABC transporter
X993_RS10170	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
X993_RS10175	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
X993_RS10195	COG1131	(ABC) transporter
X993_RS10200	COG0842	Transport permease protein
X993_RS10220	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
X993_RS10225	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
X993_RS10235	COG2095	MarC family integral membrane protein
X993_RS10285	COG0805	protein transport
X993_RS10290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X993_RS10295	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
X993_RS10300	COG0723	plastoquinol--plastocyanin reductase activity
X993_RS10305	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
X993_RS10310	COG2857	Cytochrome c1
X993_RS10315	COG0625	glutathione transferase activity
X993_RS10320	COG2969	positive regulation of protein catabolic process
X993_RS10350	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
X993_RS10355	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
X993_RS10370	COG4683	PFAM Phage derived protein Gp49-like (DUF891)
X993_RS10375	COG0582	viral genome integration into host DNA
X993_RS10515	COG0308	aminopeptidase N
X993_RS10565	COG0443	Heat shock 70 kDa protein
X993_RS10570	COG1278	Cold shock
X993_RS10575	COG0531	amino acid
X993_RS10580	COG3384	dioxygenase
X993_RS10590	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
X993_RS10595	COG2890	protein-(glutamine-N5) methyltransferase activity
X993_RS10620	COG0006	proline dipeptidase activity
X993_RS10625	COG1335	isochorismatase
X993_RS10635	COG0488	(ABC) transporter
X993_RS10650	COG0584	glycerophosphoryl diester phosphodiesterase
X993_RS10680	COG0012	GTP binding
X993_RS10705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
X993_RS10710	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
X993_RS10725	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
X993_RS10745	COG0512	Glutamine amidotransferase of anthranilate synthase
X993_RS10755	COG0546	phosphoglycolate phosphatase activity
X993_RS10760	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
X993_RS10765	COG2967	ApaG domain
X993_RS10775	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
X993_RS10785	COG2050	protein possibly involved in aromatic compounds catabolism
X993_RS10790	COG1024	Enoyl-CoA hydratase
X993_RS10795	COG0183	Belongs to the thiolase family
X993_RS10805	COG1024	Enoyl-CoA hydratase
X993_RS10835	COG0243	molybdopterin cofactor binding
X993_RS10840	COG0318	PFAM AMP-dependent synthetase and ligase
X993_RS10845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
X993_RS10865	COG3116	cell division
X993_RS10875	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
X993_RS10880	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
X993_RS10915	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
X993_RS10930	COG0678	peroxiredoxin activity
X993_RS10955	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
X993_RS10965	COG0494	nUDIX hydrolase
X993_RS10970	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
X993_RS10985	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
X993_RS10995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
X993_RS11000	COG4536	flavin adenine dinucleotide binding
X993_RS11010	COG0142	geranyltranstransferase activity
X993_RS11050	COG2095	MarC family integral membrane protein
X993_RS11055	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
X993_RS11060	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
X993_RS11100	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X993_RS11105	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
X993_RS11120	COG0439	Biotin carboxylase
X993_RS11125	COG0511	ligase activity, forming carbon-carbon bonds
X993_RS11130	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
X993_RS11135	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X993_RS11145	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
X993_RS11150	COG3150	esterase
X993_RS11155	COG0557	exoribonuclease II activity
X993_RS11160	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
X993_RS11165	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
X993_RS11180	COG1414	Transcriptional regulator
X993_RS11185	COG3734	2-keto-3-deoxy-galactonokinase
X993_RS11190	COG0352	thiamine-phosphate diphosphorylase activity
X993_RS11195	COG1028	Short-chain dehydrogenase reductase Sdr
X993_RS11210	COG1172	Belongs to the binding-protein-dependent transport system permease family
X993_RS11215	COG1028	Short-chain dehydrogenase reductase Sdr
X993_RS11225	COG0284	orotidine-5'-phosphate decarboxylase activity
X993_RS11230	COG1546	Belongs to the CinA family
X993_RS11235	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
X993_RS11265	COG1385	rRNA (uridine-N3-)-methyltransferase activity
X993_RS11275	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
X993_RS11280	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
X993_RS11285	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
X993_RS11290	COG2814	Major facilitator Superfamily
X993_RS11305	COG0583	DNA-binding transcription factor activity
X993_RS11315	COG1301	dicarboxylic acid transport
X993_RS11320	COG4266	Belongs to the allantoicase family
X993_RS11325	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
X993_RS11330	COG0735	belongs to the Fur family
X993_RS11335	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
X993_RS11365	COG1466	dna polymerase III delta subunit
X993_RS11370	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
X993_RS11375	COG1981	membrane
X993_RS11380	COG0837	glucose binding
X993_RS11380	COG1737	Transcriptional regulator
X993_RS11390	COG0800	Aldolase
X993_RS11410	COG2223	nitrite transmembrane transporter activity
X993_RS11415	COG0583	DNA-binding transcription factor activity
X993_RS11420	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
X993_RS11425	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X993_RS11430	COG0765	amino acid transport
X993_RS11435	COG0765	amino acid transport
X993_RS11440	COG1126	abc transporter atp-binding protein
X993_RS11470	COG0121	glutamine amidotransferase
X993_RS11475	COG0418	dihydroorotase activity
X993_RS11505	COG4977	sequence-specific DNA binding
X993_RS11505	COG1917	Cupin 2, conserved barrel domain protein
X993_RS11510	COG0625	glutathione transferase activity
X993_RS11515	COG0625	glutathione transferase activity
X993_RS11525	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
X993_RS11535	COG0588	phosphoglycerate mutase activity
X993_RS11575	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
X993_RS11580	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
X993_RS11585	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
X993_RS11590	COG0006	proline dipeptidase activity
X993_RS11595	COG0625	glutathione transferase activity
X993_RS11600	COG0069	glutamate synthase activity
X993_RS11675	COG3008	intermembrane lipid transfer
X993_RS11675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
X993_RS11680	COG2995	paraquat-inducible protein a
X993_RS11695	COG2353	YceI-like domain
X993_RS11700	COG2353	YceI-like domain
X993_RS11710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
X993_RS11715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
X993_RS11720	COG1862	Preprotein translocase
X993_RS11725	COG0343	queuine tRNA-ribosyltransferase activity
X993_RS11735	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
X993_RS11755	COG0783	Belongs to the Dps family
X993_RS11780	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
X993_RS11785	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
X993_RS11790	COG2188	Transcriptional regulator
X993_RS11795	COG3624	Phosphonate C-P lyase system protein PhnG
X993_RS11805	COG3626	phosphonate metabolism
X993_RS11810	COG3627	carbon phosphorus lyase activity
X993_RS11815	COG4107	phosphonate C-P lyase system protein PhnK
X993_RS11820	COG4778	phosphonate C-P lyase system protein PhnL
X993_RS11825	COG3454	Phosphonate metabolism
X993_RS11830	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
X993_RS11835	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
X993_RS11840	COG3639	organic phosphonate transmembrane transporter activity
X993_RS11855	COG0247	lactate metabolic process
X993_RS11860	COG0277	FAD linked oxidase domain protein
X993_RS11865	COG0277	FAD linked oxidase domain protein
X993_RS11870	COG0277	FAD linked oxidase domain protein
X993_RS11875	COG2096	Adenosyltransferase
X993_RS11880	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
X993_RS11880	COG1017	nitric oxide dioxygenase activity
X993_RS11885	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
X993_RS11890	COG0312	modulator of DNA gyrase
X993_RS11895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
X993_RS11900	COG3164	Protein of unknown function
X993_RS11905	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
X993_RS11910	COG0497	DNA recombination
X993_RS11915	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
X993_RS11955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
X993_RS11965	COG1428	Deoxynucleoside kinase
X993_RS11970	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
X993_RS11975	COG0617	tRNA 3'-terminal CCA addition
X993_RS11985	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
X993_RS12010	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
X993_RS12015	COG0586	Pfam SNARE associated Golgi protein
X993_RS12120	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
X993_RS12135	COG1368	sulfuric ester hydrolase activity
X993_RS12140	COG1028	Short-chain dehydrogenase reductase Sdr
X993_RS12140	COG0604	alcohol dehydrogenase
X993_RS12140	COG3321	synthase
X993_RS12145	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
X993_RS12150	COG0156	8-amino-7-oxononanoate synthase activity
X993_RS12190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
X993_RS12195	COG3206	protein involved in exopolysaccharide biosynthesis
X993_RS12195	COG0489	protein tyrosine kinase activity
X993_RS12205	COG3562	capsule polysaccharide
X993_RS12210	COG1045	serine acetyltransferase
X993_RS12225	COG2877	3-deoxy-8-phosphooctulonate synthase activity
X993_RS12230	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
X993_RS12235	COG0517	IMP dehydrogenase activity
X993_RS12235	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
X993_RS12260	COG2885	chlorophyll binding
X993_RS12285	COG0824	Thioesterase
X993_RS12290	COG4221	oxidoreductase activity
X993_RS12345	COG0450	alkyl hydroperoxide reductase
X993_RS12355	COG1960	acyl-CoA dehydrogenase activity
X993_RS12380	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
X993_RS12390	COG2814	Major facilitator Superfamily
X993_RS12410	COG2814	Major facilitator Superfamily
X993_RS12415	COG0778	Nitroreductase
X993_RS12420	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X993_RS12425	COG0583	DNA-binding transcription factor activity
X993_RS12430	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
X993_RS12455	COG1529	Aldehyde oxidase and xanthine dehydrogenase
X993_RS12475	COG4774	siderophore transport
X993_RS12480	COG1120	ATPase activity
X993_RS12490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X993_RS12530	COG0730	response to heat
X993_RS12540	COG0584	glycerophosphoryl diester phosphodiesterase
X993_RS12550	COG1280	lysine exporter protein (LysE YggA)
X993_RS12605	COG0604	alcohol dehydrogenase
X993_RS12610	COG1733	regulation of RNA biosynthetic process
X993_RS12620	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
X993_RS12635	COG1773	rubredoxin
X993_RS12655	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
X993_RS12730	COG1215	transferase activity, transferring glycosyl groups
X993_RS12745	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
X993_RS12760	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
X993_RS12785	COG0859	PFAM glycosyl transferase family 9
X993_RS12815	COG0804	urea catabolic process
X993_RS12840	COG1129	ABC transporter
X993_RS12850	COG0559	Belongs to the binding-protein-dependent transport system permease family
X993_RS12860	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
X993_RS12870	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
X993_RS12880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
X993_RS12900	COG0220	tRNA (guanine-N7-)-methyltransferase activity
X993_RS12925	COG2963	transposase activity
X993_RS12930	COG2801	Transposase and inactivated derivatives
X993_RS12945	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
X993_RS12950	COG2226	methyltransferase
X993_RS12970	COG0762	integral membrane protein
X993_RS13005	COG0436	Aminotransferase
X993_RS13030	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
X993_RS13030	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
X993_RS13050	COG2814	Major facilitator Superfamily
X993_RS13065	COG1126	abc transporter atp-binding protein
X993_RS13070	COG0765	amino acid transport
X993_RS13075	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X993_RS13080	COG1737	Transcriptional regulator
X993_RS13080	COG0837	glucose binding
X993_RS13085	COG0363	glucosamine-6-phosphate deaminase activity
X993_RS13090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
X993_RS13100	COG1175	transmembrane transport
X993_RS13105	COG0395	ABC-type sugar transport system, permease component
X993_RS13110	COG3842	ATPase activity
X993_RS13115	COG2860	membrane
X993_RS13120	COG1193	negative regulation of DNA recombination
X993_RS13125	COG0492	ferredoxin-NADP+ reductase activity
X993_RS13130	COG1674	ftsk spoiiie
X993_RS13135	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
X993_RS13145	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
X993_RS13180	COG2894	cell division
X993_RS13205	COG0859	PFAM glycosyl transferase family 9
X993_RS13215	COG0477	Major facilitator Superfamily
X993_RS13245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
X993_RS13250	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
X993_RS13260	COG1561	YicC-like family, N-terminal region
X993_RS13275	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
X993_RS13295	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
X993_RS13305	COG1278	Cold shock
X993_RS13310	COG2176	DNA-directed DNA polymerase activity
X993_RS13330	COG4772	TonB-dependent receptor
X993_RS13375	COG0583	DNA-binding transcription factor activity
X993_RS13385	COG0308	aminopeptidase N
X993_RS13395	COG2119	membrane
X993_RS13400	COG0402	S-adenosylhomocysteine deaminase activity
X993_RS13405	COG2252	PERMEase
X993_RS13410	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
X993_RS13425	COG0154	amidase activity
X993_RS13430	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
X993_RS13455	COG3383	formate dehydrogenase (NAD+) activity
X993_RS13470	COG1910	domain protein
X993_RS13480	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
X993_RS13485	COG0546	phosphoglycolate phosphatase activity
X993_RS13510	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
X993_RS13515	COG1605	Chorismate mutase
X993_RS13515	COG0077	Prephenate dehydratase
X993_RS13520	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
X993_RS13545	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
X993_RS13555	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
X993_RS13580	COG2951	lytic endotransglycosylase activity
X993_RS13585	COG0123	including yeast histone deacetylase and acetoin utilization protein
X993_RS13590	COG2267	carboxylic ester hydrolase activity
X993_RS13600	COG2011	ABC-type metal ion transport system permease component
X993_RS13620	COG1960	acyl-CoA dehydrogenase activity
X993_RS13680	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
X993_RS13695	COG0501	Belongs to the peptidase M48B family
X993_RS13705	COG0521	Mo-molybdopterin cofactor biosynthetic process
X993_RS13710	COG3028	Belongs to the UPF0307 family
X993_RS13715	COG0312	modulator of DNA gyrase
X993_RS13720	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
X993_RS13725	COG2204	response regulator
X993_RS13755	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
X993_RS13765	COG0640	Transcriptional regulator
X993_RS13780	COG0114	fumarate hydratase activity
X993_RS13785	COG0534	Mate efflux family protein
X993_RS13790	COG2501	S4 domain
X993_RS13800	COG3547	Transposase (IS116 IS110 IS902 family)
X993_RS13815	COG3045	CreA protein
X993_RS13830	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
X993_RS13835	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
X993_RS13855	COG1322	Protein conserved in bacteria
X993_RS13870	COG0303	'Molybdopterin
X993_RS13880	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
X993_RS13885	COG1530	ribonuclease E activity
X993_RS13895	COG0546	phosphoglycolate phosphatase activity
X993_RS13920	COG1399	metal-binding, possibly nucleic acid-binding protein
X993_RS13955	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
X993_RS13975	COG3026	antisigma factor binding
X993_RS13980	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X993_RS13995	COG0681	Belongs to the peptidase S26 family
X993_RS14000	COG0571	ribonuclease III activity
X993_RS14005	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
X993_RS14030	COG2204	response regulator
X993_RS14050	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
X993_RS14075	COG1956	GAF domain-containing protein
X993_RS14080	COG0583	DNA-binding transcription factor activity
X993_RS14090	COG2153	protein acetylation
X993_RS14105	COG1999	signal sequence binding
X993_RS14120	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
X993_RS14125	COG1132	(ABC) transporter
X993_RS14130	COG0438	transferase activity, transferring glycosyl groups
X993_RS14145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X993_RS14150	COG0683	leucine binding
X993_RS14155	COG3511	phospholipase C
X993_RS14160	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
X993_RS14165	COG0596	Alpha beta hydrolase
X993_RS14170	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
X993_RS14185	COG3394	polysaccharide catabolic process
X993_RS14230	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
X993_RS14265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X993_RS14275	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
X993_RS14305	COG1959	2 iron, 2 sulfur cluster binding
X993_RS14315	COG2151	metal-sulfur cluster biosynthetic enzyme
X993_RS14320	COG0822	iron-sulfur transferase activity
X993_RS14325	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
X993_RS14335	COG0396	ATPase activity
X993_RS14340	COG0719	Fe-S assembly protein
X993_RS14350	COG0840	transmembrane signaling receptor activity
X993_RS14355	COG0635	Involved in the biosynthesis of porphyrin-containing compound
X993_RS14360	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
X993_RS14375	COG0826	peptidase U32
X993_RS14380	COG0826	peptidase U32
X993_RS14385	COG3154	lipid carrier protein
X993_RS14420	COG2151	metal-sulfur cluster biosynthetic enzyme
X993_RS14435	COG0415	Belongs to the DNA photolyase family
X993_RS14440	COG0529	Catalyzes the synthesis of activated sulfate
X993_RS14475	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
X993_RS14490	COG0402	S-adenosylhomocysteine deaminase activity
X993_RS14510	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
X993_RS14515	COG0174	glutamine synthetase
X993_RS14530	COG3668	Plasmid stabilization system
X993_RS14540	COG0583	DNA-binding transcription factor activity
X993_RS14545	COG1960	acyl-CoA dehydrogenase activity
X993_RS14555	COG0477	Major facilitator Superfamily
X993_RS14565	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
X993_RS14565	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
X993_RS14570	COG1643	Atp-dependent helicase
X993_RS14590	COG1058	Belongs to the CinA family
X993_RS14590	COG1546	Belongs to the CinA family
X993_RS14600	COG0174	glutamine synthetase
X993_RS14620	COG2197	response regulator
X993_RS14625	COG4585	Histidine kinase
X993_RS14630	COG2181	nitrate reductase activity
X993_RS14635	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
X993_RS14640	COG1140	nitrate reductase beta subunit
X993_RS14645	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
X993_RS14650	COG2223	nitrite transmembrane transporter activity
X993_RS14665	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
X993_RS14670	COG0339	signal peptide processing
X993_RS14680	COG4566	intracellular signal transduction
X993_RS14690	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
X993_RS14695	COG0508	dehydrogenase complex catalyzes the overall conversion of
X993_RS14700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
X993_RS14720	COG1414	Transcriptional regulator
X993_RS14740	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
X993_RS14750	COG1104	cysteine desulfurase activity
X993_RS14755	COG0822	iron-sulfur transferase activity
X993_RS14760	COG0316	Belongs to the HesB IscA family
X993_RS14780	COG2975	iron-sulfur cluster assembly
X993_RS14800	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
X993_RS14815	COG1136	(ABC) transporter
X993_RS14820	COG0084	hydrolase, TatD family'
X993_RS14825	COG2333	competence protein COMEC
X993_RS14825	COG0658	competence protein
X993_RS14830	COG2267	carboxylic ester hydrolase activity
X993_RS14850	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
X993_RS14860	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
X993_RS14870	COG2833	Protein of unknown function (DUF455)
X993_RS14875	COG0596	Alpha beta hydrolase
X993_RS14880	COG0613	PHP domain protein
X993_RS14885	COG0009	L-threonylcarbamoyladenylate synthase
X993_RS14890	COG1994	Peptidase M50
X993_RS14895	COG0180	Tryptophanyl-tRNA synthetase
X993_RS14905	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
X993_RS14910	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
X993_RS14915	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
X993_RS14920	COG2850	peptidyl-arginine hydroxylation
X993_RS14950	COG0483	inositol monophosphate 1-phosphatase activity
X993_RS14960	COG1045	serine acetyltransferase
X993_RS14965	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
X993_RS14975	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
X993_RS15000	COG0037	tRNA processing
X993_RS15005	COG0527	aspartate kinase activity
X993_RS15035	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
X993_RS15040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X993_RS15045	COG2895	sulfate adenylyltransferase (ATP) activity
X993_RS15045	COG0529	Catalyzes the synthesis of activated sulfate
X993_RS15050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
X993_RS15075	COG2175	clavaminate synthase activity
X993_RS15095	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
X993_RS15100	COG3958	Transketolase
X993_RS15115	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
X993_RS15135	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
X993_RS15150	COG0024	Methionine aminopeptidase
X993_RS15165	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
X993_RS15175	COG0243	molybdopterin cofactor binding
X993_RS15195	COG4166	transmembrane transport
X993_RS15200	COG4174	ABC transporter (Permease)
X993_RS15205	COG4239	(ABC) transporter, permease
X993_RS15210	COG4172	Belongs to the ABC transporter superfamily
X993_RS15215	COG0791	NLP P60 protein
X993_RS15220	COG1752	Esterase of the alpha-beta hydrolase superfamily
X993_RS15280	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
X993_RS15290	COG0583	DNA-binding transcription factor activity
X993_RS15300	COG2224	Isocitrate lyase
X993_RS15305	COG0513	Belongs to the DEAD box helicase family
X993_RS15315	COG1214	PFAM Peptidase M22, glycoprotease
X993_RS15325	COG1573	uracil-dna glycosylase
X993_RS15340	COG0351	phosphomethylpyrimidine kinase
X993_RS15345	COG0477	Major facilitator Superfamily
X993_RS15365	COG0488	(ABC) transporter
X993_RS15370	COG0386	Belongs to the glutathione peroxidase family
X993_RS15385	COG2890	protein-(glutamine-N5) methyltransferase activity
X993_RS15395	COG1393	Belongs to the ArsC family
X993_RS15435	COG0242	peptide deformylase activity
X993_RS15440	COG1187	pseudouridine synthase activity
X993_RS15450	COG0024	Methionine aminopeptidase
X993_RS15480	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
X993_RS15495	COG0750	zinc metalloprotease
X993_RS15535	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
X993_RS15565	COG0330	HflC and HflK could
X993_RS15575	COG2867	negative regulation of translational initiation
X993_RS15585	COG0697	spore germination
X993_RS15620	COG2814	Major facilitator Superfamily
X993_RS15640	COG1619	proteins homologs of microcin C7 resistance protein MccF
X993_RS15650	COG1953	Uracil, thiamine, allantoin
X993_RS15665	COG3195	allantoin biosynthetic process
X993_RS15665	COG3648	Uricase
X993_RS15670	COG4266	Belongs to the allantoicase family
X993_RS15685	COG2351	hydroxyisourate hydrolase activity
X993_RS15695	COG0583	DNA-binding transcription factor activity
X993_RS15700	COG3360	Dodecin
X993_RS15755	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
X993_RS15770	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
X993_RS15880	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
X993_RS15885	COG1846	Transcriptional regulator
X993_RS15890	COG1929	Belongs to the glycerate kinase type-1 family
X993_RS15910	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
X993_RS15945	COG3547	Transposase (IS116 IS110 IS902 family)
X993_RS15970	COG4181	ATPase activity
X993_RS15985	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X993_RS15995	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
X993_RS15995	COG0047	phosphoribosylformylglycinamidine synthase activity
X993_RS16005	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
X993_RS16030	COG0318	PFAM AMP-dependent synthetase and ligase
X993_RS16035	COG1024	Enoyl-CoA hydratase
X993_RS16035	COG1250	3-hydroxyacyl-CoA dehydrogenase
X993_RS16040	COG1335	isochorismatase
X993_RS16045	COG0183	Belongs to the thiolase family
X993_RS16065	COG2130	NADP-dependent
X993_RS16070	COG0657	acetylesterase activity
X993_RS16085	COG0354	folic acid binding
X993_RS16090	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
X993_RS16105	COG1247	-acetyltransferase
X993_RS16110	COG0084	hydrolase, TatD family'
X993_RS16135	COG0438	transferase activity, transferring glycosyl groups
X993_RS16155	COG0252	asparaginase activity
X993_RS16165	COG1652	LysM domain
X993_RS16170	COG2084	Dehydrogenase
X993_RS16175	COG3622	Belongs to the hyi family
X993_RS16180	COG3960	tartronate-semialdehyde synthase activity
X993_RS16185	COG0583	DNA-binding transcription factor activity
X993_RS16240	COG0306	phosphate transporter
X993_RS16245	COG0791	NLP P60 protein
X993_RS16250	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
X993_RS16255	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
X993_RS16260	COG0726	polysaccharide deacetylase
X993_RS16265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
X993_RS16265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
X993_RS16275	COG0463	Glycosyl transferase, family 2
X993_RS16280	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
X993_RS16285	COG2076	Multidrug Resistance protein
X993_RS16290	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
X993_RS16300	COG0436	Aminotransferase
X993_RS16320	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
X993_RS16325	COG0314	molybdopterin synthase activity
X993_RS16330	COG2346	COG2346, Truncated hemoglobins
X993_RS16335	COG1959	2 iron, 2 sulfur cluster binding
X993_RS16340	COG0542	response to heat
X993_RS16365	COG0534	Mate efflux family protein
X993_RS16380	COG3228	Belongs to the MtfA family
X993_RS16385	COG0477	Major facilitator Superfamily
X993_RS16390	COG0789	Transcriptional regulator
X993_RS16395	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
X993_RS16410	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
X993_RS16425	COG1804	L-carnitine dehydratase bile acid-inducible protein F
X993_RS16470	COG0670	Belongs to the BI1 family
X993_RS16505	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
X993_RS16520	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
X993_RS16525	COG0330	HflC and HflK could
X993_RS16530	COG0330	HflC and HflK could
X993_RS16550	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
X993_RS16560	COG2183	response to ionizing radiation
X993_RS16575	COG1199	ATP-dependent helicase activity
X993_RS16585	COG0564	pseudouridine synthase activity
X993_RS16590	COG1496	oxidoreductase activity
X993_RS16595	COG3243	poly(R)-hydroxyalkanoic acid synthase
X993_RS16600	COG0183	Belongs to the thiolase family
X993_RS16605	COG1028	Short-chain dehydrogenase reductase Sdr
X993_RS16625	COG0183	Belongs to the thiolase family
X993_RS16635	COG0626	cystathionine gamma-synthase activity
X993_RS16640	COG0560	Phosphoserine phosphatase
X993_RS16655	COG0390	transport system, permease component
X993_RS16660	COG1122	ATPase activity
X993_RS16665	COG2982	Protein involved in outer membrane biogenesis
X993_RS16675	COG0488	(ABC) transporter
X993_RS16690	COG2070	2-Nitropropane dioxygenase
X993_RS16695	COG3047	cAMP biosynthetic process
X993_RS16705	COG1914	H( )-stimulated, divalent metal cation uptake system
X993_RS16710	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
X993_RS16715	COG3842	ATPase activity
X993_RS16720	COG1176	ABC-type spermidine putrescine transport system, permease component I
X993_RS16725	COG1177	transmembrane transport
X993_RS16730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X993_RS16730	COG0730	response to heat
X993_RS16755	COG3655	Transcriptional regulator
X993_RS16775	COG1538	Outer membrane efflux protein
X993_RS16780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
X993_RS16795	COG0038	chloride channel
X993_RS16800	COG2855	membrane
X993_RS16820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X993_RS16830	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X993_RS16835	COG1609	Transcriptional regulator
X993_RS16925	COG0598	Magnesium transport protein CorA
X993_RS16955	COG3264	Mechanosensitive ion channel
X993_RS16955	COG1196	nuclear chromosome segregation
X993_RS16985	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
X993_RS17000	COG4263	nitrous-oxide reductase activity
X993_RS17020	COG0840	transmembrane signaling receptor activity
X993_RS17030	COG2376	Dihydroxyacetone kinase
X993_RS17050	COG0475	glutathione-regulated potassium exporter activity
X993_RS17110	COG3121	Chaperone
X993_RS17115	COG3188	usher protein
X993_RS17145	COG5295	Hep Hag repeat protein
X993_RS17160	COG2197	response regulator
X993_RS17210	COG4145	pantothenate transmembrane transporter activity
X993_RS17220	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
X993_RS17285	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
X993_RS17290	COG1012	belongs to the aldehyde dehydrogenase family
X993_RS17315	COG3842	ATPase activity
X993_RS17330	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
X993_RS17340	COG2916	Histone family protein nucleoid-structuring protein H-NS
X993_RS17370	COG2274	protein secretion by the type I secretion system
X993_RS17375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X993_RS17385	COG0457	Tetratricopeptide repeat
X993_RS17385	COG0859	PFAM glycosyl transferase family 9
X993_RS17395	COG0529	Catalyzes the synthesis of activated sulfate
X993_RS17400	COG0745	RESPONSE REGULATOR receiver
X993_RS17405	COG3547	Transposase (IS116 IS110 IS902 family)
X993_RS17430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
X993_RS17440	COG2986	histidine ammonia-lyase
X993_RS17450	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
X993_RS17465	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
X993_RS17485	COG1595	DNA-templated transcription, initiation
X993_RS17490	COG4944	Protein of unknown function (DUF1109)
X993_RS17510	COG3220	belongs to the UPF0276 family
X993_RS17530	COG2192	nodulation
X993_RS17555	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
X993_RS17575	COG0165	Argininosuccinate lyase
X993_RS17580	COG0137	argininosuccinate synthase activity
X993_RS17595	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
X993_RS17605	COG3251	PFAM MbtH domain protein
X993_RS17620	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
X993_RS17625	COG2207	Transcriptional regulator
X993_RS17630	COG0697	spore germination
X993_RS17635	COG0835	chemotaxis
X993_RS17660	COG0318	PFAM AMP-dependent synthetase and ligase
X993_RS17675	COG1732	Glycine betaine
X993_RS17680	COG1174	glycine betaine transport
X993_RS17685	COG1125	glycine betaine transport
X993_RS17690	COG1174	glycine betaine transport
X993_RS17705	COG2235	arginine
X993_RS17710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
X993_RS17730	COG0583	DNA-binding transcription factor activity
X993_RS17735	COG0625	glutathione transferase activity
X993_RS17750	COG1846	Transcriptional regulator
X993_RS17755	COG2807	transmembrane transport
X993_RS17760	COG1649	PFAM Uncharacterised BCR, COG1649
X993_RS17780	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
X993_RS17790	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
X993_RS17810	COG3979	chitinase
X993_RS17820	COG0400	carboxylic ester hydrolase activity
X993_RS17885	COG4774	siderophore transport
X993_RS18045	COG0840	transmembrane signaling receptor activity
X993_RS18590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
X993_RS18790	COG0840	transmembrane signaling receptor activity
X993_RS18820	COG0210	DNA helicase
X993_RS18845	COG5002	protein histidine kinase activity
X993_RS19085	COG4999	Histidine kinase
X993_RS19085	COG3850	Histidine kinase
X993_RS19085	COG3437	response regulator, receiver
X993_RS19085	COG2205	protein histidine kinase activity
X993_RS19455	COG1523	belongs to the glycosyl hydrolase 13 family
X993_RS19605	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
X993_RS20005	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X993_RS20010	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X993_RS20015	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X993_RS20110	COG0556	nucleotide-excision repair
X993_RS20290	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
X993_RS20405	COG0154	amidase activity
X993_RS21200	COG1028	Short-chain dehydrogenase reductase Sdr
X993_RS21505	COG0795	lipopolysaccharide-transporting ATPase activity
X993_RS22765	COG5265	(ABC) transporter
X993_RS22815	COG1960	acyl-CoA dehydrogenase activity
X993_RS23155	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
X993_RS23450	COG0587	DNA-directed DNA polymerase activity
X993_RS23490	COG1612	heme a metabolic process
X993_RS23725	COG0405	Gamma-glutamyltransferase
X993_RS23800	COG0737	Belongs to the 5'-nucleotidase family
X993_RS23985	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
X993_RS24255	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X993_RS24970	COG5000	phosphorelay sensor kinase activity
X993_RS25235	COG0582	viral genome integration into host DNA
X993_RS25285	COG0187	DNA topoisomerase II activity
X993_RS26080	COG5377	YqaJ viral recombinase family
X993_RS26315	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
X993_RS27590	COG0006	proline dipeptidase activity
X993_RS27995	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
X993_RS28115	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
X993_RS28115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
X993_RS28355	COG0625	glutathione transferase activity
X993_RS28430	COG0006	proline dipeptidase activity
X993_RS28525	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
X993_RS28745	COG0497	DNA recombination
X993_RS28850	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
X993_RS29185	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
X993_RS29520	COG1215	transferase activity, transferring glycosyl groups
X993_RS29855	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
X993_RS29890	COG1674	ftsk spoiiie
X993_RS29905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
X993_RS29990	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
X993_RS30075	COG0308	aminopeptidase N
X993_RS30080	COG0308	aminopeptidase N
X993_RS30160	COG3383	formate dehydrogenase (NAD+) activity
X993_RS30165	COG3383	formate dehydrogenase (NAD+) activity
X993_RS30210	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
X993_RS30240	COG2011	ABC-type metal ion transport system permease component
X993_RS30360	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
X993_RS30400	COG3547	Transposase (IS116 IS110 IS902 family)
X993_RS30475	COG1530	ribonuclease E activity
X993_RS31430	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
X993_RS31460	COG1529	Aldehyde oxidase and xanthine dehydrogenase