locus-tag	class	description
X994_RS00210	COG3511	phospholipase C
X994_RS00240	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
X994_RS00420	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
X994_RS00470	COG0683	leucine binding
X994_RS00625	COG0719	Fe-S assembly protein
X994_RS00795	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
X994_RS00880	COG1804	L-carnitine dehydratase bile acid-inducible protein F
X994_RS00905	COG1643	Atp-dependent helicase
X994_RS01235	COG2333	competence protein COMEC
X994_RS01235	COG0658	competence protein
X994_RS01290	COG0596	Alpha beta hydrolase
X994_RS01550	COG1472	Belongs to the glycosyl hydrolase 3 family
X994_RS01645	COG3511	phospholipase C
X994_RS01810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
X994_RS01825	COG0396	ATPase activity
X994_RS02090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
X994_RS02090	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
X994_RS02140	COG3852	Histidine kinase
X994_RS02170	COG1140	nitrate reductase beta subunit
X994_RS02180	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
X994_RS02370	COG0658	competence protein
X994_RS02370	COG2333	competence protein COMEC
X994_RS02765	COG0527	aspartate kinase activity
X994_RS02825	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
X994_RS03430	COG1752	Esterase of the alpha-beta hydrolase superfamily
X994_RS03640	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
X994_RS04315	COG3960	tartronate-semialdehyde synthase activity
X994_RS04420	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
X994_RS04525	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
X994_RS04545	COG1804	L-carnitine dehydratase bile acid-inducible protein F
X994_RS04585	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
X994_RS04695	COG0488	(ABC) transporter
X994_RS05010	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
X994_RS05075	COG0840	transmembrane signaling receptor activity
X994_RS05220	COG5295	Hep Hag repeat protein
X994_RS05790	COG0165	Argininosuccinate lyase
X994_RS05885	COG1732	Glycine betaine
X994_RS06160	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
X994_RS06200	COG1063	alcohol dehydrogenase
X994_RS06375	COG2719	SpoVR family
X994_RS06805	COG1846	Transcriptional regulator
X994_RS07070	COG0277	FAD linked oxidase domain protein
X994_RS07250	COG1116	anion transmembrane transporter activity
X994_RS07345	COG1804	L-carnitine dehydratase bile acid-inducible protein F
X994_RS07750	COG0366	Alpha amylase catalytic
X994_RS07835	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
X994_RS08035	COG0328	RNA-DNA hybrid ribonuclease activity
X994_RS08140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X994_RS08655	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
X994_RS08695	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
X994_RS09125	COG2205	protein histidine kinase activity
X994_RS09395	COG2706	6-phosphogluconolactonase activity
X994_RS09665	COG0582	viral genome integration into host DNA
X994_RS10310	COG0583	DNA-binding transcription factor activity
X994_RS10465	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
X994_RS10950	COG0469	pyruvate kinase activity
X994_RS11230	COG2010	Cytochrome c
X994_RS11585	COG5265	(ABC) transporter
X994_RS12120	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
X994_RS12125	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
X994_RS12210	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
X994_RS12385	COG1960	acyl-CoA dehydrogenase activity
X994_RS12440	COG0587	DNA-directed DNA polymerase activity
X994_RS12830	COG0288	reversible hydration of carbon dioxide
X994_RS13125	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X994_RS13355	COG0531	amino acid
X994_RS13405	COG1157	protein secretion by the type III secretion system
X994_RS13720	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X994_RS14305	COG0683	leucine binding
X994_RS14325	COG1960	acyl-CoA dehydrogenase activity
X994_RS14335	COG0436	Aminotransferase
X994_RS14595	COG5377	YqaJ viral recombinase family
X994_RS14915	COG0681	Belongs to the peptidase S26 family
X994_RS14920	COG0571	ribonuclease III activity
X994_RS14925	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
X994_RS14950	COG2204	response regulator
X994_RS14970	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
X994_RS14990	COG1956	GAF domain-containing protein
X994_RS14995	COG0583	DNA-binding transcription factor activity
X994_RS15005	COG2153	protein acetylation
X994_RS15020	COG1999	signal sequence binding
X994_RS15035	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
X994_RS15040	COG1132	(ABC) transporter
X994_RS15045	COG0438	transferase activity, transferring glycosyl groups
X994_RS15060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X994_RS15065	COG0683	leucine binding
X994_RS15070	COG3511	phospholipase C
X994_RS15080	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
X994_RS15085	COG0596	Alpha beta hydrolase
X994_RS15090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
X994_RS15105	COG3394	polysaccharide catabolic process
X994_RS15140	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
X994_RS15175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X994_RS15185	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
X994_RS15215	COG1959	2 iron, 2 sulfur cluster binding
X994_RS15225	COG2151	metal-sulfur cluster biosynthetic enzyme
X994_RS15230	COG0822	iron-sulfur transferase activity
X994_RS15235	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
X994_RS15245	COG0396	ATPase activity
X994_RS15250	COG0719	Fe-S assembly protein
X994_RS15260	COG0840	transmembrane signaling receptor activity
X994_RS15265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
X994_RS15270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
X994_RS15285	COG0826	peptidase U32
X994_RS15290	COG0826	peptidase U32
X994_RS15295	COG3154	lipid carrier protein
X994_RS15330	COG2151	metal-sulfur cluster biosynthetic enzyme
X994_RS15345	COG0415	Belongs to the DNA photolyase family
X994_RS15350	COG0529	Catalyzes the synthesis of activated sulfate
X994_RS15385	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
X994_RS15400	COG0402	S-adenosylhomocysteine deaminase activity
X994_RS15425	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
X994_RS15430	COG0174	glutamine synthetase
X994_RS15445	COG3668	Plasmid stabilization system
X994_RS15460	COG0583	DNA-binding transcription factor activity
X994_RS15465	COG1960	acyl-CoA dehydrogenase activity
X994_RS15475	COG0477	Major facilitator Superfamily
X994_RS15485	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
X994_RS15485	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
X994_RS15490	COG1643	Atp-dependent helicase
X994_RS15510	COG1546	Belongs to the CinA family
X994_RS15510	COG1058	Belongs to the CinA family
X994_RS15520	COG0174	glutamine synthetase
X994_RS15540	COG2197	response regulator
X994_RS15545	COG4585	Histidine kinase
X994_RS15550	COG2181	nitrate reductase activity
X994_RS15555	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
X994_RS15560	COG1140	nitrate reductase beta subunit
X994_RS15565	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
X994_RS15570	COG2223	nitrite transmembrane transporter activity
X994_RS15585	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
X994_RS15590	COG0339	signal peptide processing
X994_RS15600	COG4566	intracellular signal transduction
X994_RS15610	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
X994_RS15615	COG0508	dehydrogenase complex catalyzes the overall conversion of
X994_RS15620	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
X994_RS15640	COG1414	Transcriptional regulator
X994_RS15660	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
X994_RS15670	COG1104	cysteine desulfurase activity
X994_RS15675	COG0822	iron-sulfur transferase activity
X994_RS15680	COG0316	Belongs to the HesB IscA family
X994_RS15700	COG2975	iron-sulfur cluster assembly
X994_RS15720	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
X994_RS15735	COG1136	(ABC) transporter
X994_RS15740	COG0084	hydrolase, TatD family'
X994_RS15745	COG2333	competence protein COMEC
X994_RS15745	COG0658	competence protein
X994_RS15750	COG2267	carboxylic ester hydrolase activity
X994_RS15770	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
X994_RS15780	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
X994_RS15790	COG2833	Protein of unknown function (DUF455)
X994_RS15795	COG0596	Alpha beta hydrolase
X994_RS15800	COG0613	PHP domain protein
X994_RS15805	COG0009	L-threonylcarbamoyladenylate synthase
X994_RS15810	COG1994	Peptidase M50
X994_RS15815	COG0180	Tryptophanyl-tRNA synthetase
X994_RS15825	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
X994_RS15830	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
X994_RS15835	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
X994_RS15840	COG2850	peptidyl-arginine hydroxylation
X994_RS16110	COG3311	Transcriptional regulator
X994_RS16135	COG0483	inositol monophosphate 1-phosphatase activity
X994_RS16145	COG1045	serine acetyltransferase
X994_RS16150	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
X994_RS16160	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
X994_RS16185	COG0037	tRNA processing
X994_RS16190	COG0527	aspartate kinase activity
X994_RS16200	COG0326	Molecular chaperone. Has ATPase activity
X994_RS16210	COG2189	Belongs to the N(4) N(6)-methyltransferase family
X994_RS16220	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
X994_RS16240	COG2336	PFAM SpoVT AbrB
X994_RS16285	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
X994_RS16295	COG0583	DNA-binding transcription factor activity
X994_RS16305	COG3842	ATPase activity
X994_RS16315	COG1177	transmembrane transport
X994_RS16330	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X994_RS16330	COG2022	thiamine diphosphate biosynthetic process
X994_RS16335	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
X994_RS16465	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
X994_RS16525	COG0270	DNA (cytosine-5-)-methyltransferase activity
X994_RS16540	COG0629	single-stranded DNA binding
X994_RS16585	COG1309	transcriptional regulator
X994_RS16610	COG0582	viral genome integration into host DNA
X994_RS16650	COG2895	sulfate adenylyltransferase (ATP) activity
X994_RS16650	COG0529	Catalyzes the synthesis of activated sulfate
X994_RS16655	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
X994_RS16685	COG2175	clavaminate synthase activity
X994_RS16705	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
X994_RS16710	COG3958	Transketolase
X994_RS16725	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
X994_RS16745	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
X994_RS16760	COG0024	Methionine aminopeptidase
X994_RS16780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
X994_RS16795	COG0243	molybdopterin cofactor binding
X994_RS16815	COG4166	transmembrane transport
X994_RS16820	COG4174	ABC transporter (Permease)
X994_RS16825	COG4239	(ABC) transporter, permease
X994_RS16830	COG4172	Belongs to the ABC transporter superfamily
X994_RS16835	COG0791	NLP P60 protein
X994_RS16840	COG1752	Esterase of the alpha-beta hydrolase superfamily
X994_RS16895	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
X994_RS16905	COG0583	DNA-binding transcription factor activity
X994_RS16915	COG2224	Isocitrate lyase
X994_RS16920	COG0513	Belongs to the DEAD box helicase family
X994_RS16930	COG1214	PFAM Peptidase M22, glycoprotease
X994_RS16940	COG1573	uracil-dna glycosylase
X994_RS16955	COG0351	phosphomethylpyrimidine kinase
X994_RS16960	COG0477	Major facilitator Superfamily
X994_RS16980	COG0488	(ABC) transporter
X994_RS16985	COG0386	Belongs to the glutathione peroxidase family
X994_RS17000	COG2890	protein-(glutamine-N5) methyltransferase activity
X994_RS17010	COG1393	Belongs to the ArsC family
X994_RS17050	COG0242	peptide deformylase activity
X994_RS17055	COG1187	pseudouridine synthase activity
X994_RS17065	COG0024	Methionine aminopeptidase
X994_RS17095	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
X994_RS17110	COG0750	zinc metalloprotease
X994_RS17150	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
X994_RS17180	COG0330	HflC and HflK could
X994_RS17190	COG2867	negative regulation of translational initiation
X994_RS17200	COG0697	spore germination
X994_RS17260	COG1196	nuclear chromosome segregation
X994_RS17270	COG2814	Major facilitator Superfamily
X994_RS17290	COG1619	proteins homologs of microcin C7 resistance protein MccF
X994_RS17300	COG1953	Uracil, thiamine, allantoin
X994_RS17315	COG3195	allantoin biosynthetic process
X994_RS17315	COG3648	Uricase
X994_RS17320	COG4266	Belongs to the allantoicase family
X994_RS17335	COG2351	hydroxyisourate hydrolase activity
X994_RS17345	COG0583	DNA-binding transcription factor activity
X994_RS17350	COG3360	Dodecin
X994_RS17410	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
X994_RS17425	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
X994_RS17545	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
X994_RS17550	COG1846	Transcriptional regulator
X994_RS17555	COG1929	Belongs to the glycerate kinase type-1 family
X994_RS17575	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
X994_RS17625	COG4181	ATPase activity
X994_RS17640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
X994_RS17650	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
X994_RS17650	COG0047	phosphoribosylformylglycinamidine synthase activity
X994_RS17660	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
X994_RS17685	COG0318	PFAM AMP-dependent synthetase and ligase
X994_RS17690	COG1250	3-hydroxyacyl-CoA dehydrogenase
X994_RS17690	COG1024	Enoyl-CoA hydratase
X994_RS17695	COG1335	isochorismatase
X994_RS17700	COG0183	Belongs to the thiolase family
X994_RS17720	COG2130	NADP-dependent
X994_RS17725	COG0657	acetylesterase activity
X994_RS17740	COG0354	folic acid binding
X994_RS17745	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
X994_RS17760	COG1247	-acetyltransferase
X994_RS17765	COG0084	hydrolase, TatD family'
X994_RS17790	COG0438	transferase activity, transferring glycosyl groups
X994_RS17810	COG0252	asparaginase activity
X994_RS17820	COG1652	LysM domain
X994_RS17830	COG2084	Dehydrogenase
X994_RS17835	COG3622	Belongs to the hyi family
X994_RS17840	COG3960	tartronate-semialdehyde synthase activity
X994_RS17845	COG0583	DNA-binding transcription factor activity
X994_RS17900	COG0306	phosphate transporter
X994_RS17905	COG0791	NLP P60 protein
X994_RS17910	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
X994_RS17915	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
X994_RS17920	COG0726	polysaccharide deacetylase
X994_RS17925	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
X994_RS17925	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
X994_RS17935	COG0463	Glycosyl transferase, family 2
X994_RS17940	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
X994_RS17945	COG2076	Multidrug Resistance protein
X994_RS17950	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
X994_RS17960	COG0436	Aminotransferase
X994_RS17980	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
X994_RS17985	COG0314	molybdopterin synthase activity
X994_RS17990	COG2346	COG2346, Truncated hemoglobins
X994_RS17995	COG1959	2 iron, 2 sulfur cluster binding
X994_RS18000	COG0542	response to heat
X994_RS18025	COG0534	Mate efflux family protein
X994_RS18040	COG3228	Belongs to the MtfA family
X994_RS18045	COG0477	Major facilitator Superfamily
X994_RS18050	COG0789	Transcriptional regulator
X994_RS18055	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
X994_RS18070	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
X994_RS18085	COG1804	L-carnitine dehydratase bile acid-inducible protein F
X994_RS18130	COG0670	Belongs to the BI1 family
X994_RS18165	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
X994_RS18180	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
X994_RS18185	COG0330	HflC and HflK could
X994_RS18190	COG0330	HflC and HflK could
X994_RS18210	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
X994_RS18220	COG2183	response to ionizing radiation
X994_RS18235	COG1199	ATP-dependent helicase activity
X994_RS18245	COG0564	pseudouridine synthase activity
X994_RS18250	COG1496	oxidoreductase activity
X994_RS18255	COG3243	poly(R)-hydroxyalkanoic acid synthase
X994_RS18260	COG0183	Belongs to the thiolase family
X994_RS18265	COG1028	Short-chain dehydrogenase reductase Sdr
X994_RS18285	COG0183	Belongs to the thiolase family
X994_RS18295	COG0626	cystathionine gamma-synthase activity
X994_RS18300	COG0560	Phosphoserine phosphatase
X994_RS18310	COG0390	transport system, permease component
X994_RS18315	COG1122	ATPase activity
X994_RS18320	COG2982	Protein involved in outer membrane biogenesis
X994_RS18330	COG0488	(ABC) transporter
X994_RS18345	COG2070	2-Nitropropane dioxygenase
X994_RS18350	COG3047	cAMP biosynthetic process
X994_RS18360	COG1914	H( )-stimulated, divalent metal cation uptake system
X994_RS18365	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
X994_RS18370	COG3842	ATPase activity
X994_RS18375	COG1176	ABC-type spermidine putrescine transport system, permease component I
X994_RS18380	COG1177	transmembrane transport
X994_RS18385	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X994_RS18385	COG0730	response to heat
X994_RS18410	COG3655	Transcriptional regulator
X994_RS18435	COG1538	Outer membrane efflux protein
X994_RS18440	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
X994_RS18455	COG0038	chloride channel
X994_RS18460	COG2855	membrane
X994_RS18480	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X994_RS18490	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X994_RS18495	COG1609	Transcriptional regulator
X994_RS18625	COG3264	Mechanosensitive ion channel
X994_RS18625	COG1196	nuclear chromosome segregation
X994_RS18655	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
X994_RS18670	COG4263	nitrous-oxide reductase activity
X994_RS18695	COG0840	transmembrane signaling receptor activity
X994_RS18705	COG2376	Dihydroxyacetone kinase
X994_RS18720	COG0475	glutathione-regulated potassium exporter activity
X994_RS18780	COG3121	Chaperone
X994_RS18785	COG3188	usher protein
X994_RS18815	COG5295	Hep Hag repeat protein
X994_RS18830	COG2197	response regulator
X994_RS18885	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
X994_RS18890	COG1012	belongs to the aldehyde dehydrogenase family
X994_RS18905	COG1176	ABC-type spermidine putrescine transport system, permease component I
X994_RS18915	COG3842	ATPase activity
X994_RS18930	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
X994_RS18940	COG2916	Histone family protein nucleoid-structuring protein H-NS
X994_RS18970	COG2274	protein secretion by the type I secretion system
X994_RS18975	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X994_RS18985	COG0859	PFAM glycosyl transferase family 9
X994_RS18985	COG0457	Tetratricopeptide repeat
X994_RS18995	COG0529	Catalyzes the synthesis of activated sulfate
X994_RS19000	COG0745	RESPONSE REGULATOR receiver
X994_RS19025	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
X994_RS19035	COG2986	histidine ammonia-lyase
X994_RS19045	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
X994_RS19060	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
X994_RS19075	COG1595	DNA-templated transcription, initiation
X994_RS19080	COG4944	Protein of unknown function (DUF1109)
X994_RS19100	COG3220	belongs to the UPF0276 family
X994_RS19110	COG2801	Transposase and inactivated derivatives
X994_RS19145	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
X994_RS19195	COG5295	Hep Hag repeat protein
X994_RS19195	COG5295	Hep Hag repeat protein
X994_RS19340	COG2192	nodulation
X994_RS19365	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
X994_RS19385	COG0165	Argininosuccinate lyase
X994_RS19390	COG0137	argininosuccinate synthase activity
X994_RS19405	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
X994_RS19415	COG3251	PFAM MbtH domain protein
X994_RS19430	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
X994_RS19435	COG2207	Transcriptional regulator
X994_RS19440	COG0697	spore germination
X994_RS19445	COG0835	chemotaxis
X994_RS19465	COG0318	PFAM AMP-dependent synthetase and ligase
X994_RS19470	COG0477	Major facilitator Superfamily
X994_RS19480	COG1732	Glycine betaine
X994_RS19485	COG1174	glycine betaine transport
X994_RS19490	COG1125	glycine betaine transport
X994_RS19495	COG1174	glycine betaine transport
X994_RS19510	COG2235	arginine
X994_RS19515	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
X994_RS19540	COG0583	DNA-binding transcription factor activity
X994_RS19545	COG0625	glutathione transferase activity
X994_RS19560	COG1846	Transcriptional regulator
X994_RS19565	COG2807	transmembrane transport
X994_RS19570	COG1649	PFAM Uncharacterised BCR, COG1649
X994_RS19585	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
X994_RS19595	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
X994_RS19625	COG0400	carboxylic ester hydrolase activity
X994_RS19630	COG4644	lycopene metabolic process
X994_RS19640	COG3209	COG3209 Rhs family protein
X994_RS19675	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
X994_RS19700	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
X994_RS19705	COG4774	siderophore transport
X994_RS19710	COG3486	L-lysine 6-monooxygenase (NADPH) activity
X994_RS19750	COG1120	ATPase activity
X994_RS19775	COG1028	Short-chain dehydrogenase reductase Sdr
X994_RS19780	COG1070	Carbohydrate kinase
X994_RS19785	COG1063	alcohol dehydrogenase
X994_RS19790	COG1172	Belongs to the binding-protein-dependent transport system permease family
X994_RS19800	COG1879	ABC-type sugar transport system periplasmic component
X994_RS19820	COG1132	(ABC) transporter
X994_RS19820	COG2375	cellular response to nickel ion
X994_RS19830	COG3121	Chaperone
X994_RS19840	COG3539	Fimbrial protein
X994_RS19855	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
X994_RS19865	COG1309	transcriptional regulator
X994_RS19870	COG0739	heme binding
X994_RS19875	COG0765	amino acid transport
X994_RS19880	COG4597	amino acid ABC transporter
X994_RS19895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X994_RS19940	COG4964	Belongs to the GSP D family
X994_RS19960	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
X994_RS19965	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
X994_RS19980	COG0477	Major facilitator Superfamily
X994_RS19985	COG2719	SpoVR family
X994_RS19990	COG2718	Belongs to the UPF0229 family
X994_RS19995	COG2766	serine protein kinase
X994_RS20000	COG0840	transmembrane signaling receptor activity
X994_RS20005	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X994_RS20010	COG1609	Transcriptional regulator
X994_RS20015	COG1172	Belongs to the binding-protein-dependent transport system permease family
X994_RS20020	COG1129	ABC transporter
X994_RS20025	COG1879	ABC-type sugar transport system periplasmic component
X994_RS20030	COG0583	DNA-binding transcription factor activity
X994_RS20035	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
X994_RS20040	COG4208	sulfate ABC transporter
X994_RS20045	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
X994_RS20050	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
X994_RS20090	COG0701	Predicted permease
X994_RS20095	COG0667	Aldo Keto reductase
X994_RS20120	COG1301	dicarboxylic acid transport
X994_RS20150	COG1116	anion transmembrane transporter activity
X994_RS20155	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
X994_RS20210	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X994_RS20215	COG0765	amino acid transport
X994_RS20220	COG0673	inositol 2-dehydrogenase activity
X994_RS20225	COG1802	Transcriptional regulator
X994_RS20235	COG3023	N-Acetylmuramoyl-L-alanine amidase
X994_RS20245	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
X994_RS20250	COG0557	exoribonuclease II activity
X994_RS20265	COG0840	transmembrane signaling receptor activity
X994_RS20290	COG0519	Catalyzes the synthesis of GMP from XMP
X994_RS20300	COG2814	Major facilitator Superfamily
X994_RS20310	COG0318	PFAM AMP-dependent synthetase and ligase
X994_RS20375	COG4964	Belongs to the GSP D family
X994_RS20430	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
X994_RS20435	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
X994_RS20440	COG0508	dehydrogenase complex catalyzes the overall conversion of
X994_RS20445	COG0567	Dehydrogenase, E1 component
X994_RS20450	COG1217	gtp-binding protein TYPA
X994_RS20455	COG1846	Transcriptional regulator
X994_RS20465	COG1566	PFAM secretion protein HlyD family protein
X994_RS20470	COG2814	Major facilitator Superfamily
X994_RS20475	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
X994_RS20490	COG0195	Participates in both transcription termination and antitermination
X994_RS20490	COG2251	uridine kinase activity
X994_RS20500	COG1187	pseudouridine synthase activity
X994_RS20505	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
X994_RS20510	COG0583	DNA-binding transcription factor activity
X994_RS20550	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
X994_RS20570	COG2755	lipolytic protein G-D-S-L family
X994_RS20570	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
X994_RS20585	COG0776	regulation of translation
X994_RS20610	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
X994_RS20625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
X994_RS20630	COG0251	oxidation-reduction process
X994_RS20635	COG2267	carboxylic ester hydrolase activity
X994_RS20645	COG0583	DNA-binding transcription factor activity
X994_RS20660	COG1028	Short-chain dehydrogenase reductase Sdr
X994_RS20695	COG1028	Short-chain dehydrogenase reductase Sdr
X994_RS20720	COG0477	Major facilitator Superfamily
X994_RS20735	COG1295	ribonuclease BN
X994_RS20750	COG0277	FAD linked oxidase domain protein
X994_RS20765	COG0583	DNA-binding transcription factor activity
X994_RS20790	COG0840	transmembrane signaling receptor activity
X994_RS20795	COG2223	nitrite transmembrane transporter activity
X994_RS20800	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
X994_RS20805	COG0210	DNA helicase
X994_RS20810	COG0525	valine-tRNA ligase activity
X994_RS20815	COG1210	Utp--glucose-1-phosphate uridylyltransferase
X994_RS20825	COG5002	protein histidine kinase activity
X994_RS20835	COG0745	RESPONSE REGULATOR receiver
X994_RS20845	COG0425	Belongs to the sulfur carrier protein TusA family
X994_RS20850	COG0673	inositol 2-dehydrogenase activity
X994_RS20855	COG0673	inositol 2-dehydrogenase activity
X994_RS20870	COG1172	Belongs to the binding-protein-dependent transport system permease family
X994_RS20885	COG3962	Belongs to the TPP enzyme family
X994_RS20895	COG3718	enzyme involved in inositol metabolism
X994_RS20905	COG0411	ABC transporter
X994_RS20915	COG0824	Thioesterase
X994_RS20930	COG2816	NAD+ diphosphatase activity
X994_RS20940	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X994_RS20950	COG0477	Major facilitator Superfamily
X994_RS20965	COG1804	L-carnitine dehydratase bile acid-inducible protein F
X994_RS20975	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
X994_RS20980	COG1051	belongs to the nudix hydrolase family
X994_RS21000	COG1858	cytochrome C peroxidase
X994_RS21005	COG3511	phospholipase C
X994_RS21015	COG1566	PFAM secretion protein HlyD family protein
X994_RS21020	COG2814	Major facilitator Superfamily
X994_RS21025	COG1538	Outer membrane efflux protein
X994_RS21030	COG2197	response regulator
X994_RS21070	COG0583	DNA-binding transcription factor activity
X994_RS21075	COG2814	Major facilitator Superfamily
X994_RS21100	COG1914	H( )-stimulated, divalent metal cation uptake system
X994_RS21255	COG0457	Tetratricopeptide repeat
X994_RS21255	COG0859	PFAM glycosyl transferase family 9
X994_RS21305	COG0745	RESPONSE REGULATOR receiver
X994_RS21310	COG0583	DNA-binding transcription factor activity
X994_RS21350	COG0366	Alpha amylase catalytic
X994_RS21355	COG0366	Alpha amylase catalytic
X994_RS21360	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
X994_RS21430	COG0582	viral genome integration into host DNA
X994_RS21455	COG4942	peptidase
X994_RS21460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
X994_RS21470	COG0534	Mate efflux family protein
X994_RS21540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
X994_RS21550	COG0745	RESPONSE REGULATOR receiver
X994_RS21565	COG0581	inorganic phosphate transmembrane transporter activity
X994_RS21570	COG0573	inorganic phosphate transmembrane transporter activity
X994_RS21575	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
X994_RS21585	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
X994_RS21590	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
X994_RS21600	COG1534	Rna-binding protein
X994_RS21610	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
X994_RS21615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
X994_RS21625	COG0505	Belongs to the CarA family
X994_RS21645	COG1388	LysM domain
X994_RS21645	COG0741	lytic transglycosylase activity
X994_RS21650	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X994_RS21655	COG2226	methyltransferase
X994_RS21660	COG0328	RNA-DNA hybrid ribonuclease activity
X994_RS21665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
X994_RS21675	COG0477	Major facilitator Superfamily
X994_RS21700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
X994_RS21710	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
X994_RS21730	COG3052	prosthetic group binding
X994_RS21750	COG0583	DNA-binding transcription factor activity
X994_RS21755	COG1250	3-hydroxyacyl-CoA dehydrogenase
X994_RS21760	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
X994_RS21795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X994_RS21830	COG0583	DNA-binding transcription factor activity
X994_RS21850	COG1522	sequence-specific DNA binding
X994_RS21900	COG0582	viral genome integration into host DNA
X994_RS21950	COG0592	DNA-directed DNA polymerase activity
X994_RS21955	COG2176	DNA-directed DNA polymerase activity
X994_RS21980	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
X994_RS22150	COG1609	Transcriptional regulator
X994_RS22155	COG1840	ABC-type Fe3 transport system, periplasmic component
X994_RS22160	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
X994_RS22175	COG1177	transmembrane transport
X994_RS22180	COG3842	ATPase activity
X994_RS22185	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
X994_RS22205	COG2814	Major facilitator Superfamily
X994_RS22210	COG0697	spore germination
X994_RS22220	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
X994_RS22225	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
X994_RS22265	COG2200	EAL domain
X994_RS22275	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
X994_RS22280	COG1074	ATP-dependent DNA helicase activity
X994_RS22285	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
X994_RS22295	COG1289	transmembrane transporter activity
X994_RS22310	COG1840	ABC-type Fe3 transport system, periplasmic component
X994_RS22315	COG1176	ABC-type spermidine putrescine transport system, permease component I
X994_RS22320	COG3842	ATPase activity
X994_RS22325	COG1522	sequence-specific DNA binding
X994_RS22340	COG1959	2 iron, 2 sulfur cluster binding
X994_RS22370	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
X994_RS22375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
X994_RS22410	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
X994_RS22425	COG2010	Cytochrome c
X994_RS22425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
X994_RS22430	COG2863	cytochrome
X994_RS22450	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
X994_RS22460	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
X994_RS22480	COG0006	proline dipeptidase activity
X994_RS22530	COG2866	Carboxypeptidase
X994_RS22545	COG0436	Aminotransferase
X994_RS22555	COG1024	Enoyl-CoA hydratase
X994_RS22560	COG0588	phosphoglycerate mutase activity
X994_RS22570	COG1960	acyl-CoA dehydrogenase activity
X994_RS22590	COG2030	dehydratase
X994_RS22590	COG1012	belongs to the aldehyde dehydrogenase family
X994_RS22595	COG1960	acyl-CoA dehydrogenase activity
X994_RS22600	COG1960	acyl-CoA dehydrogenase activity
X994_RS22620	COG1007	ATP synthesis coupled electron transport
X994_RS22655	COG1034	ATP synthesis coupled electron transport
X994_RS22665	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
X994_RS22700	COG0149	triose-phosphate isomerase activity
X994_RS22705	COG4221	oxidoreductase activity
X994_RS22705	COG3321	synthase
X994_RS22705	COG0604	alcohol dehydrogenase
X994_RS22705	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
X994_RS22720	COG0683	leucine binding
X994_RS22730	COG0288	reversible hydration of carbon dioxide
X994_RS22735	COG0659	secondary active sulfate transmembrane transporter activity
X994_RS22745	COG1183	phosphatidylcholine synthase activity
X994_RS22765	COG0028	Belongs to the TPP enzyme family
X994_RS22795	COG0438	transferase activity, transferring glycosyl groups
X994_RS22815	COG1028	Short-chain dehydrogenase reductase Sdr
X994_RS22820	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
X994_RS22830	COG0154	amidase activity
X994_RS22840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
X994_RS22870	COG0745	RESPONSE REGULATOR receiver
X994_RS22875	COG2205	protein histidine kinase activity
X994_RS22890	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
X994_RS22895	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
X994_RS22915	COG1028	Short-chain dehydrogenase reductase Sdr
X994_RS22930	COG0151	Belongs to the GarS family
X994_RS22945	COG0799	negative regulation of ribosome biogenesis
X994_RS22965	COG2233	PERMEase
X994_RS23005	COG1595	DNA-templated transcription, initiation
X994_RS23010	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
X994_RS23040	COG0859	PFAM glycosyl transferase family 9
X994_RS23045	COG0438	transferase activity, transferring glycosyl groups
X994_RS23085	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
X994_RS23090	COG0513	Belongs to the DEAD box helicase family
X994_RS23125	COG1674	ftsk spoiiie
X994_RS23130	COG2706	6-phosphogluconolactonase activity
X994_RS23135	COG3387	PFAM Glycoside hydrolase 15-related
X994_RS23145	COG1309	transcriptional regulator
X994_RS23150	COG2878	Part of a membrane complex involved in electron transport
X994_RS23155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
X994_RS23190	COG3135	benzoate transporter
X994_RS23205	COG2764	glyoxalase bleomycin resistance protein dioxygenase
X994_RS23220	COG4106	trans-aconitate 2-methyltransferase activity
X994_RS23240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X994_RS23250	COG0697	spore germination
X994_RS23255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
X994_RS23295	COG0477	Major facilitator Superfamily
X994_RS23300	COG0583	DNA-binding transcription factor activity
X994_RS23310	COG0583	DNA-binding transcription factor activity
X994_RS23340	COG0488	(ABC) transporter
X994_RS23350	COG1773	rubredoxin
X994_RS23395	COG0582	viral genome integration into host DNA
X994_RS23475	COG2963	transposase activity
X994_RS23535	COG1881	PFAM PEBP family protein
X994_RS23540	COG2814	Major facilitator Superfamily
X994_RS23560	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
X994_RS23580	COG1116	anion transmembrane transporter activity
X994_RS23585	COG1176	ABC-type spermidine putrescine transport system, permease component I
X994_RS23610	COG1741	Belongs to the pirin family
X994_RS23625	COG4215	(ABC) transporter
X994_RS23645	COG0347	Belongs to the P(II) protein family
X994_RS23670	COG2827	Endonuclease containing a URI domain
X994_RS23675	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
X994_RS23690	COG2271	Major facilitator Superfamily
X994_RS23720	COG2226	methyltransferase
X994_RS23760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
X994_RS23785	COG0489	protein tyrosine kinase activity
X994_RS23790	COG2885	chlorophyll binding
X994_RS23790	COG3047	cAMP biosynthetic process
X994_RS23810	COG2911	Protein conserved in bacteria
X994_RS23815	COG0729	surface antigen
X994_RS23825	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
X994_RS23840	COG0489	protein tyrosine kinase activity
X994_RS23845	COG2259	Doxx family
X994_RS23850	COG1492	cobalamin metabolic process
X994_RS23860	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
X994_RS23870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
X994_RS23885	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
X994_RS23890	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
X994_RS23895	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
X994_RS23905	COG4206	TonB-dependent receptor
X994_RS23935	COG0583	DNA-binding transcription factor activity
X994_RS23945	COG4654	Cytochrome c, class I
X994_RS23965	COG0795	lipopolysaccharide-transporting ATPase activity
X994_RS23980	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
X994_RS23980	COG1648	precorrin-2 dehydrogenase activity
X994_RS23985	COG2895	sulfate adenylyltransferase (ATP) activity
X994_RS23995	COG0175	sulfate reduction
X994_RS24010	COG0583	DNA-binding transcription factor activity
X994_RS24020	COG0582	viral genome integration into host DNA
X994_RS24075	COG1396	sequence-specific DNA binding
X994_RS24085	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
X994_RS24090	COG2258	MOSC domain
X994_RS24095	COG2267	carboxylic ester hydrolase activity
X994_RS24105	COG0583	DNA-binding transcription factor activity
X994_RS24115	COG1187	pseudouridine synthase activity
X994_RS24130	COG0543	2 iron, 2 sulfur cluster binding
X994_RS24130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
X994_RS24135	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
X994_RS24140	COG0456	acetyltransferase
X994_RS24175	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
X994_RS24180	COG1047	Peptidyl-prolyl cis-trans
X994_RS24200	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
X994_RS24220	COG1511	domain protein
X994_RS24220	COG3264	Mechanosensitive ion channel
X994_RS24225	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
X994_RS24225	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
X994_RS24230	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
X994_RS24235	COG0196	riboflavin kinase activity
X994_RS24240	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
X994_RS24270	COG1113	amino acid transport
X994_RS24275	COG0542	response to heat
X994_RS24285	COG1278	Cold shock
X994_RS24290	COG2132	Multicopper oxidase
X994_RS24310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
X994_RS24330	COG0656	L-ascorbic acid biosynthetic process
X994_RS24335	COG2188	Transcriptional regulator
X994_RS24355	COG2814	Major facilitator Superfamily
X994_RS24400	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
X994_RS24405	COG1570	exodeoxyribonuclease VII activity
X994_RS24440	COG0728	peptidoglycan biosynthetic process
X994_RS24455	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
X994_RS24460	COG0812	UDP-N-acetylmuramate dehydrogenase activity
X994_RS24475	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
X994_RS24480	COG0318	PFAM AMP-dependent synthetase and ligase
X994_RS24485	COG4974	Belongs to the 'phage' integrase family
X994_RS24495	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
X994_RS24500	COG0802	atpase or kinase
X994_RS24505	COG0860	N-Acetylmuramoyl-L-alanine amidase
X994_RS24515	COG1741	Belongs to the pirin family
X994_RS24520	COG3118	belongs to the thioredoxin family
X994_RS24525	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
X994_RS24535	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
X994_RS24550	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
X994_RS24560	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
X994_RS24565	COG1522	sequence-specific DNA binding
X994_RS24585	COG2271	Major facilitator Superfamily
X994_RS24595	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
X994_RS24600	COG1012	belongs to the aldehyde dehydrogenase family
X994_RS24610	COG0583	DNA-binding transcription factor activity
X994_RS24615	COG0246	Mannitol dehydrogenase
X994_RS24620	COG1070	Carbohydrate kinase
X994_RS24625	COG2390	Transcriptional regulator
X994_RS24640	COG0583	DNA-binding transcription factor activity
X994_RS24650	COG3842	ATPase activity
X994_RS24655	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
X994_RS24665	COG1175	transmembrane transport
X994_RS24680	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X994_RS24690	COG0735	belongs to the Fur family
X994_RS24700	COG1121	(ABC) transporter
X994_RS24705	COG1108	ABC-type Mn2 Zn2 transport systems permease components
X994_RS24710	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
X994_RS24725	COG1070	Carbohydrate kinase
X994_RS24730	COG2233	PERMEase
X994_RS24745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
X994_RS24750	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X994_RS24775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X994_RS24805	COG0009	L-threonylcarbamoyladenylate synthase
X994_RS24810	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
X994_RS24815	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
X994_RS24820	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
X994_RS24830	COG0469	pyruvate kinase activity
X994_RS24835	COG0126	phosphoglycerate kinase activity
X994_RS24860	COG0859	PFAM glycosyl transferase family 9
X994_RS24870	COG0429	hydrolase of the alpha beta-hydrolase fold
X994_RS24880	COG4783	chaperone-mediated protein folding
X994_RS24900	COG3307	-O-antigen
X994_RS24905	COG4969	Belongs to the N-Me-Phe pilin family
X994_RS24910	COG0861	Integral membrane protein TerC family
X994_RS24915	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
X994_RS24930	COG2137	regulation of response to DNA damage stimulus
X994_RS24935	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
X994_RS24970	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
X994_RS25000	COG0583	DNA-binding transcription factor activity
X994_RS25045	COG0784	Response regulator, receiver
X994_RS25045	COG5002	protein histidine kinase activity
X994_RS25050	COG0583	DNA-binding transcription factor activity
X994_RS25090	COG0028	Belongs to the TPP enzyme family
X994_RS25095	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
X994_RS25100	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
X994_RS25170	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
X994_RS25175	COG0583	DNA-binding transcription factor activity
X994_RS25195	COG0840	transmembrane signaling receptor activity
X994_RS25235	COG4948	Mandelate Racemase Muconate Lactonizing
X994_RS25255	COG0513	Belongs to the DEAD box helicase family
X994_RS25295	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
X994_RS25300	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
X994_RS25310	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
X994_RS25315	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
X994_RS25320	COG0367	asparagine synthase
X994_RS25335	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
X994_RS25345	COG1396	sequence-specific DNA binding
X994_RS25350	COG2814	Major facilitator Superfamily
X994_RS25355	COG0583	DNA-binding transcription factor activity
X994_RS25365	COG1702	phosphate starvation-inducible protein PhoH
X994_RS25375	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
X994_RS25385	COG0815	Transfers the fatty acyl group on membrane lipoproteins
X994_RS25390	COG0752	glycyl-tRNA synthetase alpha subunit
X994_RS25395	COG0751	glycine-tRNA ligase activity
X994_RS25400	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
X994_RS25405	COG0204	Acyl-transferase
X994_RS25430	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
X994_RS25450	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
X994_RS25460	COG5265	(ABC) transporter
X994_RS25475	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
X994_RS25480	COG1024	Enoyl-CoA hydratase
X994_RS25485	COG0183	Belongs to the thiolase family
X994_RS25490	COG1250	3-hydroxyacyl-CoA dehydrogenase
X994_RS25490	COG1024	Enoyl-CoA hydratase
X994_RS25495	COG1960	acyl-CoA dehydrogenase activity
X994_RS25510	COG0494	nUDIX hydrolase
X994_RS25575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
X994_RS25585	COG0251	oxidation-reduction process
X994_RS25590	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
X994_RS25615	COG0477	Major facilitator Superfamily
X994_RS25645	COG1596	polysaccharide export
X994_RS25650	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
X994_RS25665	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
X994_RS25675	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
X994_RS25695	COG2204	response regulator
X994_RS25730	COG5002	protein histidine kinase activity
X994_RS25730	COG5001	Diguanylate cyclase
X994_RS25735	COG0235	Class ii aldolase
X994_RS25805	COG3328	transposase activity
X994_RS25875	COG0629	single-stranded DNA binding
X994_RS25880	COG2814	Major facilitator Superfamily
X994_RS25905	COG1280	lysine exporter protein (LysE YggA)
X994_RS25925	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
X994_RS25940	COG1137	ATPase activity
X994_RS25945	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
X994_RS25950	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
X994_RS25975	COG1194	a g-specific adenine glycosylase
X994_RS25990	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
X994_RS26005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
X994_RS26025	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
X994_RS26035	COG0742	ribosomal rna small subunit methyltransferase
X994_RS26045	COG0625	glutathione transferase activity
X994_RS26055	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
X994_RS26065	COG0243	molybdopterin cofactor binding
X994_RS26070	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
X994_RS26080	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
X994_RS26090	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
X994_RS26095	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
X994_RS26110	COG1294	oxidase, subunit
X994_RS26130	COG1263	PTS System
X994_RS26130	COG2190	(PTS) system
X994_RS26130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
X994_RS26135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
X994_RS26135	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
X994_RS26140	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
X994_RS26145	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
X994_RS26150	COG2188	Transcriptional regulator
X994_RS26155	COG0583	DNA-binding transcription factor activity
X994_RS26200	COG0318	PFAM AMP-dependent synthetase and ligase
X994_RS26210	COG1960	acyl-CoA dehydrogenase activity
X994_RS26220	COG2226	methyltransferase
X994_RS26230	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
X994_RS26255	COG2814	Major facilitator Superfamily
X994_RS26265	COG0587	DNA-directed DNA polymerase activity
X994_RS26280	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
X994_RS26300	COG0840	transmembrane signaling receptor activity
X994_RS26310	COG1999	signal sequence binding
X994_RS26320	COG1612	heme a metabolic process
X994_RS26350	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
X994_RS26360	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
X994_RS26375	COG2226	methyltransferase
X994_RS26380	COG1040	competence protein
X994_RS26390	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
X994_RS26410	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
X994_RS26420	COG0793	Belongs to the peptidase S41A family
X994_RS26425	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
X994_RS26430	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
X994_RS26435	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
X994_RS26445	COG0189	ligase activity
X994_RS26455	COG0004	ammonium transporteR
X994_RS26465	COG2960	long-chain fatty acid transporting porin activity
X994_RS26495	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X994_RS26505	COG4191	Histidine kinase
X994_RS26515	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
X994_RS26525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
X994_RS26530	COG1960	acyl-CoA dehydrogenase activity
X994_RS26535	COG1960	acyl-CoA dehydrogenase activity
X994_RS26540	COG1250	3-hydroxyacyl-CoA dehydrogenase
X994_RS26540	COG1024	Enoyl-CoA hydratase
X994_RS26545	COG0583	DNA-binding transcription factor activity
X994_RS26585	COG0583	DNA-binding transcription factor activity
X994_RS26590	COG2921	Belongs to the UPF0250 family
X994_RS26600	COG1686	Belongs to the peptidase S11 family
X994_RS26635	COG1127	ABC transporter
X994_RS26640	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
X994_RS26645	COG0737	Belongs to the 5'-nucleotidase family
X994_RS26660	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
X994_RS26670	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
X994_RS26690	COG1024	Enoyl-CoA hydratase
X994_RS26740	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
X994_RS26745	COG4221	oxidoreductase activity
X994_RS26750	COG1028	Short-chain dehydrogenase reductase Sdr
X994_RS26765	COG0747	negative chemotaxis
X994_RS26770	COG0488	(ABC) transporter
X994_RS26785	COG0288	reversible hydration of carbon dioxide
X994_RS26790	COG0183	Belongs to the thiolase family
X994_RS26800	COG3012	SEC-C Motif Domain Protein
X994_RS26820	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
X994_RS26845	COG1785	Belongs to the alkaline phosphatase family
X994_RS26855	COG2200	EAL domain
X994_RS26855	COG2199	diguanylate cyclase activity
X994_RS26860	COG0025	NhaP-type Na H and K H
X994_RS26890	COG2204	response regulator
X994_RS26920	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
X994_RS26935	COG1999	signal sequence binding
X994_RS26970	COG3511	phospholipase C
X994_RS26990	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
X994_RS27020	COG0596	Alpha beta hydrolase
X994_RS27030	COG0583	DNA-binding transcription factor activity
X994_RS27035	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
X994_RS27050	COG0840	transmembrane signaling receptor activity
X994_RS27055	COG1609	Transcriptional regulator
X994_RS27110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
X994_RS27130	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
X994_RS27135	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
X994_RS27155	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
X994_RS27160	COG1704	LemA family
X994_RS27255	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
X994_RS27265	COG2824	Alkylphosphonate utilization operon protein PhnA
X994_RS27285	COG0583	DNA-binding transcription factor activity
X994_RS27290	COG2233	PERMEase
X994_RS27295	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
X994_RS27305	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
X994_RS27315	COG1706	bacterial-type flagellum-dependent cell motility
X994_RS27320	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
X994_RS27335	COG1749	Flagellar hook protein flgE
X994_RS27340	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
X994_RS27345	COG1558	bacterial-type flagellum-dependent cell motility
X994_RS27350	COG1815	bacterial-type flagellum-dependent cell motility
X994_RS27360	COG2747	anti-sigma28 factor FlgM
X994_RS27390	COG0741	lytic transglycosylase activity
X994_RS27395	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
X994_RS27405	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
X994_RS27410	COG1984	allophanate hydrolase subunit 2
X994_RS27440	COG4608	Belongs to the ABC transporter superfamily
X994_RS27445	COG0444	Belongs to the ABC transporter superfamily
X994_RS27450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
X994_RS27455	COG0601	transmembrane transport
X994_RS27460	COG0747	negative chemotaxis
X994_RS27475	COG0579	oxidoreductase
X994_RS27495	COG3568	Endonuclease Exonuclease Phosphatase
X994_RS27500	COG1280	lysine exporter protein (LysE YggA)
X994_RS27520	COG0531	amino acid
X994_RS27535	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
X994_RS27595	COG1960	acyl-CoA dehydrogenase activity
X994_RS27610	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
X994_RS27620	COG2814	Major facilitator Superfamily
X994_RS27635	COG0667	Aldo Keto reductase
X994_RS27660	COG1560	Kdo2-lipid A biosynthetic process
X994_RS27675	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
X994_RS27685	COG0523	cobalamin synthesis protein
X994_RS27705	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
X994_RS27730	COG1309	transcriptional regulator
X994_RS27745	COG2814	Major facilitator Superfamily
X994_RS27755	COG2207	Transcriptional regulator
X994_RS27760	COG1064	alcohol dehydrogenase
X994_RS27765	COG0708	Exodeoxyribonuclease III
X994_RS27770	COG2326	polyphosphate kinase activity
X994_RS27790	COG1077	Cell shape determining protein MreB Mrl
X994_RS27805	COG0768	penicillin binding
X994_RS27810	COG0772	Belongs to the SEDS family
X994_RS27830	COG0720	synthase
X994_RS27835	COG0602	queuosine metabolic process
X994_RS27850	COG2204	response regulator
X994_RS27855	COG5000	phosphorelay sensor kinase activity
X994_RS27865	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
X994_RS27865	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
X994_RS27890	COG0242	peptide deformylase activity
X994_RS27895	COG0758	DNA mediated transformation
X994_RS27910	COG0583	DNA-binding transcription factor activity
X994_RS27915	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X994_RS27940	COG3328	transposase activity
X994_RS27945	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
X994_RS27965	COG4695	Portal protein
X994_RS27975	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
X994_RS27990	COG0583	DNA-binding transcription factor activity
X994_RS28010	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
X994_RS28025	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
X994_RS28025	COG2169	Transcriptional regulator
X994_RS28045	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
X994_RS28120	COG0582	viral genome integration into host DNA
X994_RS28160	COG0592	DNA-directed DNA polymerase activity
X994_RS28175	COG0753	catalase activity
X994_RS28215	COG1804	L-carnitine dehydratase bile acid-inducible protein F
X994_RS28220	COG1250	3-hydroxyacyl-CoA dehydrogenase
X994_RS28220	COG1024	Enoyl-CoA hydratase
X994_RS28225	COG0183	Belongs to the thiolase family
X994_RS28230	COG1960	acyl-CoA dehydrogenase activity
X994_RS28255	COG1695	Transcriptional regulator
X994_RS28335	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
X994_RS28350	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
X994_RS28360	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
X994_RS28375	COG0789	Transcriptional regulator
X994_RS28385	COG1987	bacterial-type flagellum assembly
X994_RS28400	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
X994_RS28415	COG1346	cytolysis
X994_RS28425	COG0583	DNA-binding transcription factor activity
X994_RS28430	COG2814	Major facilitator Superfamily
X994_RS28435	COG1846	Transcriptional regulator
X994_RS28480	COG2165	general secretion pathway protein
X994_RS28495	COG1459	type II secretion system
X994_RS28515	COG0523	cobalamin synthesis protein
X994_RS28545	COG0518	GMP synthase (glutamine-hydrolyzing) activity
X994_RS28545	COG0519	Catalyzes the synthesis of GMP from XMP
X994_RS28550	COG1902	pentaerythritol trinitrate reductase activity
X994_RS28565	COG0642	Histidine kinase
X994_RS28585	COG3186	Phenylalanine-4-hydroxylase
X994_RS28590	COG1522	sequence-specific DNA binding
X994_RS28600	COG0583	DNA-binding transcription factor activity
X994_RS28610	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
X994_RS28630	COG0559	Belongs to the binding-protein-dependent transport system permease family
X994_RS28675	COG1192	Involved in chromosome partitioning
X994_RS28680	COG1475	DNA binding
X994_RS28685	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
X994_RS28695	COG0356	it plays a direct role in the translocation of protons across the membrane
X994_RS28735	COG0318	PFAM AMP-dependent synthetase and ligase
X994_RS28740	COG1832	CoA-binding protein
X994_RS28755	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
X994_RS28765	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
X994_RS28765	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
X994_RS28765	COG0506	proline dehydrogenase activity
X994_RS28780	COG1960	acyl-CoA dehydrogenase activity
X994_RS28790	COG0436	Aminotransferase
X994_RS28805	COG0277	FAD linked oxidase domain protein
X994_RS28815	COG0789	Transcriptional regulator
X994_RS28835	COG0668	transmembrane transport
X994_RS28855	COG0531	amino acid
X994_RS28860	COG4303	Ethanolamine ammonia lyase large subunit
X994_RS28865	COG4302	ethanolamine ammonia-lyase activity
X994_RS28875	COG1012	belongs to the aldehyde dehydrogenase family
X994_RS28900	COG1760	l-serine dehydratase
X994_RS28915	COG0509	glycine decarboxylation via glycine cleavage system
X994_RS28930	COG0673	inositol 2-dehydrogenase activity
X994_RS28945	COG0210	DNA helicase
X994_RS28950	COG3245	cytochrome
X994_RS28965	COG3311	Transcriptional regulator
X994_RS29045	COG5377	YqaJ viral recombinase family
X994_RS29060	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
X994_RS29065	COG0210	DNA helicase
X994_RS29090	COG0582	viral genome integration into host DNA
X994_RS29125	COG3397	chitin binding
X994_RS29145	COG2267	carboxylic ester hydrolase activity
X994_RS29205	COG1028	Short-chain dehydrogenase reductase Sdr
X994_RS29220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
X994_RS29255	COG0519	Catalyzes the synthesis of GMP from XMP
X994_RS29265	COG0561	phosphatase activity
X994_RS29270	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
X994_RS29280	COG0438	transferase activity, transferring glycosyl groups
X994_RS29300	COG1360	Flagellar Motor Protein
X994_RS29305	COG2201	protein-glutamate methylesterase activity
X994_RS29325	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
X994_RS29335	COG2201	protein-glutamate methylesterase activity
X994_RS29340	COG0745	RESPONSE REGULATOR receiver
X994_RS29345	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
X994_RS29365	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
X994_RS29370	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
X994_RS29395	COG1950	PFAM Membrane protein of
X994_RS29400	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
X994_RS29415	COG2070	2-Nitropropane dioxygenase
X994_RS29440	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
X994_RS29445	COG1522	sequence-specific DNA binding
X994_RS29455	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
X994_RS29475	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
X994_RS29480	COG2823	Periplasmic or secreted lipoprotein
X994_RS29495	COG1113	amino acid transport
X994_RS29525	COG2084	Dehydrogenase
X994_RS29530	COG1280	lysine exporter protein (LysE YggA)
X994_RS29535	COG2814	Major facilitator Superfamily
X994_RS29540	COG0583	DNA-binding transcription factor activity
X994_RS29545	COG3047	cAMP biosynthetic process
X994_RS29560	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
X994_RS29570	COG1881	PFAM PEBP family protein
X994_RS29575	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
X994_RS29580	COG0281	malic enzyme
X994_RS29580	COG0280	phosphate acetyltransferase
X994_RS29600	COG1522	sequence-specific DNA binding
X994_RS29620	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
X994_RS29625	COG2151	metal-sulfur cluster biosynthetic enzyme
X994_RS29630	COG3396	Phenylacetate-CoA oxygenase
X994_RS29635	COG3460	Phenylacetate-CoA oxygenase
X994_RS29640	COG3396	Phenylacetate-CoA oxygenase
X994_RS29700	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
X994_RS29740	COG0514	ATP-dependent DNA helicase (RecQ)
X994_RS29870	COG0201	protein transport
X994_RS29915	COG4232	protein-disulfide reductase activity
X994_RS29935	COG1333	cytochrome c biogenesis protein
X994_RS29940	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
X994_RS29945	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
X994_RS29950	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
X994_RS30005	COG0232	Belongs to the dGTPase family. Type 2 subfamily
X994_RS30015	COG1175	transmembrane transport
X994_RS30020	COG0395	ABC-type sugar transport system, permease component
X994_RS30025	COG3842	ATPase activity
X994_RS30030	COG0584	glycerophosphoryl diester phosphodiesterase
X994_RS30045	COG0067	glutamate synthase
X994_RS30045	COG0069	glutamate synthase activity
X994_RS30045	COG0070	glutamate synthase
X994_RS30055	COG1115	amino acid carrier protein
X994_RS30065	COG4178	(ABC) transporter
X994_RS30090	COG1127	ABC transporter
X994_RS30095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
X994_RS30100	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
X994_RS30120	COG1131	(ABC) transporter
X994_RS30125	COG0842	Transport permease protein
X994_RS30150	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
X994_RS30160	COG2095	MarC family integral membrane protein
X994_RS30210	COG0805	protein transport
X994_RS30220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
X994_RS30225	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
X994_RS30230	COG0723	plastoquinol--plastocyanin reductase activity
X994_RS30235	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
X994_RS30240	COG2857	Cytochrome c1
X994_RS30245	COG0625	glutathione transferase activity
X994_RS30250	COG2969	positive regulation of protein catabolic process
X994_RS30265	COG4695	Portal protein
X994_RS30270	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
X994_RS30275	COG3657	addiction module killer protein
X994_RS30305	COG3328	transposase activity
X994_RS30430	COG0308	aminopeptidase N
X994_RS30475	COG0443	Heat shock 70 kDa protein
X994_RS30480	COG1278	Cold shock
X994_RS30485	COG0531	amino acid
X994_RS30490	COG3384	dioxygenase
X994_RS30500	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
X994_RS30505	COG2890	protein-(glutamine-N5) methyltransferase activity
X994_RS30530	COG0006	proline dipeptidase activity
X994_RS30540	COG1335	isochorismatase
X994_RS30550	COG0488	(ABC) transporter
X994_RS30560	COG0584	glycerophosphoryl diester phosphodiesterase
X994_RS30590	COG0012	GTP binding
X994_RS30605	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
X994_RS30610	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
X994_RS30625	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
X994_RS30645	COG0512	Glutamine amidotransferase of anthranilate synthase
X994_RS30655	COG0546	phosphoglycolate phosphatase activity
X994_RS30660	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
X994_RS30665	COG2967	ApaG domain
X994_RS30675	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
X994_RS30685	COG2050	protein possibly involved in aromatic compounds catabolism
X994_RS30690	COG1024	Enoyl-CoA hydratase
X994_RS30695	COG0183	Belongs to the thiolase family
X994_RS30705	COG1024	Enoyl-CoA hydratase
X994_RS30735	COG0243	molybdopterin cofactor binding
X994_RS30740	COG0318	PFAM AMP-dependent synthetase and ligase
X994_RS30745	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
X994_RS30765	COG3116	cell division
X994_RS30775	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
X994_RS30780	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
X994_RS30815	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
X994_RS30830	COG0678	peroxiredoxin activity
X994_RS30850	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
X994_RS30860	COG0494	nUDIX hydrolase
X994_RS30865	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
X994_RS30880	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
X994_RS30890	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
X994_RS30895	COG4536	flavin adenine dinucleotide binding
X994_RS30905	COG0142	geranyltranstransferase activity
X994_RS30945	COG2095	MarC family integral membrane protein
X994_RS30950	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
X994_RS30955	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
X994_RS30995	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
X994_RS31000	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
X994_RS31015	COG0439	Biotin carboxylase
X994_RS31020	COG0511	ligase activity, forming carbon-carbon bonds
X994_RS31025	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
X994_RS31030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
X994_RS31040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
X994_RS31045	COG3150	esterase
X994_RS31050	COG0557	exoribonuclease II activity
X994_RS31055	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
X994_RS31060	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
X994_RS31075	COG1414	Transcriptional regulator
X994_RS31080	COG3734	2-keto-3-deoxy-galactonokinase
X994_RS31090	COG1028	Short-chain dehydrogenase reductase Sdr
X994_RS31105	COG1172	Belongs to the binding-protein-dependent transport system permease family
X994_RS31110	COG1028	Short-chain dehydrogenase reductase Sdr
X994_RS31120	COG0284	orotidine-5'-phosphate decarboxylase activity
X994_RS31125	COG1546	Belongs to the CinA family
X994_RS31130	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
X994_RS31160	COG1385	rRNA (uridine-N3-)-methyltransferase activity
X994_RS31170	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
X994_RS31175	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
X994_RS31180	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
X994_RS31185	COG2814	Major facilitator Superfamily
X994_RS31200	COG0583	DNA-binding transcription factor activity
X994_RS31210	COG1301	dicarboxylic acid transport
X994_RS31215	COG4266	Belongs to the allantoicase family
X994_RS31220	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
X994_RS31225	COG0735	belongs to the Fur family
X994_RS31230	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
X994_RS31260	COG1466	dna polymerase III delta subunit
X994_RS31265	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
X994_RS31270	COG1981	membrane
X994_RS31280	COG0837	glucose binding
X994_RS31280	COG1737	Transcriptional regulator
X994_RS31290	COG0800	Aldolase
X994_RS31310	COG2223	nitrite transmembrane transporter activity
X994_RS31315	COG0583	DNA-binding transcription factor activity
X994_RS31320	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
X994_RS31325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X994_RS31330	COG0765	amino acid transport
X994_RS31335	COG0765	amino acid transport
X994_RS31340	COG1126	abc transporter atp-binding protein
X994_RS31375	COG0121	glutamine amidotransferase
X994_RS31380	COG0418	dihydroorotase activity
X994_RS31410	COG1917	Cupin 2, conserved barrel domain protein
X994_RS31410	COG4977	sequence-specific DNA binding
X994_RS31415	COG0625	glutathione transferase activity
X994_RS31420	COG0625	glutathione transferase activity
X994_RS31430	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
X994_RS31440	COG0588	phosphoglycerate mutase activity
X994_RS31480	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
X994_RS31485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
X994_RS31490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
X994_RS31495	COG0006	proline dipeptidase activity
X994_RS31500	COG0625	glutathione transferase activity
X994_RS31505	COG0069	glutamate synthase activity
X994_RS31575	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
X994_RS31575	COG3008	intermembrane lipid transfer
X994_RS31580	COG2995	paraquat-inducible protein a
X994_RS31595	COG2353	YceI-like domain
X994_RS31600	COG2353	YceI-like domain
X994_RS31610	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
X994_RS31615	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
X994_RS31620	COG1862	Preprotein translocase
X994_RS31630	COG0343	queuine tRNA-ribosyltransferase activity
X994_RS31635	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
X994_RS31640	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
X994_RS31660	COG0783	Belongs to the Dps family
X994_RS31685	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
X994_RS31690	COG2188	Transcriptional regulator
X994_RS31695	COG3624	Phosphonate C-P lyase system protein PhnG
X994_RS31705	COG3626	phosphonate metabolism
X994_RS31710	COG3627	carbon phosphorus lyase activity
X994_RS31715	COG4107	phosphonate C-P lyase system protein PhnK
X994_RS31720	COG4778	phosphonate C-P lyase system protein PhnL
X994_RS31725	COG3454	Phosphonate metabolism
X994_RS31730	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
X994_RS31735	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
X994_RS31740	COG3639	organic phosphonate transmembrane transporter activity
X994_RS31755	COG0247	lactate metabolic process
X994_RS31760	COG0277	FAD linked oxidase domain protein
X994_RS31765	COG0277	FAD linked oxidase domain protein
X994_RS31770	COG0277	FAD linked oxidase domain protein
X994_RS31775	COG2096	Adenosyltransferase
X994_RS31780	COG1017	nitric oxide dioxygenase activity
X994_RS31780	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
X994_RS31785	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
X994_RS31790	COG0312	modulator of DNA gyrase
X994_RS31795	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
X994_RS31800	COG3164	Protein of unknown function
X994_RS31805	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
X994_RS31810	COG0497	DNA recombination
X994_RS31815	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
X994_RS31855	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
X994_RS31865	COG1428	Deoxynucleoside kinase
X994_RS31870	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
X994_RS31875	COG0617	tRNA 3'-terminal CCA addition
X994_RS31885	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
X994_RS31910	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
X994_RS31915	COG0586	Pfam SNARE associated Golgi protein
X994_RS32020	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
X994_RS32035	COG1368	sulfuric ester hydrolase activity
X994_RS32040	COG1028	Short-chain dehydrogenase reductase Sdr
X994_RS32040	COG0604	alcohol dehydrogenase
X994_RS32040	COG3321	synthase
X994_RS32045	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
X994_RS32050	COG0156	8-amino-7-oxononanoate synthase activity
X994_RS32090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
X994_RS32095	COG3206	protein involved in exopolysaccharide biosynthesis
X994_RS32095	COG0489	protein tyrosine kinase activity
X994_RS32110	COG1045	serine acetyltransferase
X994_RS32125	COG2877	3-deoxy-8-phosphooctulonate synthase activity
X994_RS32130	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
X994_RS32135	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
X994_RS32135	COG0517	IMP dehydrogenase activity
X994_RS32160	COG2885	chlorophyll binding
X994_RS32185	COG0824	Thioesterase
X994_RS32190	COG4221	oxidoreductase activity
X994_RS32245	COG0450	alkyl hydroperoxide reductase
X994_RS32255	COG1960	acyl-CoA dehydrogenase activity
X994_RS32280	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
X994_RS32290	COG2814	Major facilitator Superfamily
X994_RS32315	COG2814	Major facilitator Superfamily
X994_RS32320	COG0778	Nitroreductase
X994_RS32325	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
X994_RS32330	COG0583	DNA-binding transcription factor activity
X994_RS32335	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
X994_RS32365	COG1529	Aldehyde oxidase and xanthine dehydrogenase
X994_RS32385	COG4774	siderophore transport
X994_RS32390	COG1120	ATPase activity
X994_RS32400	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
X994_RS32440	COG0730	response to heat
X994_RS32450	COG0584	glycerophosphoryl diester phosphodiesterase
X994_RS32455	COG1280	lysine exporter protein (LysE YggA)
X994_RS32505	COG0604	alcohol dehydrogenase
X994_RS32510	COG1733	regulation of RNA biosynthetic process
X994_RS32520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
X994_RS32535	COG1773	rubredoxin
X994_RS32555	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
X994_RS32630	COG1215	transferase activity, transferring glycosyl groups
X994_RS32645	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
X994_RS32660	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
X994_RS32685	COG0859	PFAM glycosyl transferase family 9
X994_RS32740	COG1129	ABC transporter
X994_RS32750	COG0559	Belongs to the binding-protein-dependent transport system permease family
X994_RS32760	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
X994_RS32770	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
X994_RS32780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
X994_RS32820	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
X994_RS32825	COG2226	methyltransferase
X994_RS32845	COG0762	integral membrane protein
X994_RS32885	COG0436	Aminotransferase
X994_RS32910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
X994_RS32910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
X994_RS32930	COG2814	Major facilitator Superfamily
X994_RS32945	COG1126	abc transporter atp-binding protein
X994_RS32950	COG0765	amino acid transport
X994_RS32955	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
X994_RS32960	COG0837	glucose binding
X994_RS32960	COG1737	Transcriptional regulator
X994_RS32965	COG0363	glucosamine-6-phosphate deaminase activity
X994_RS32970	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
X994_RS32980	COG1175	transmembrane transport
X994_RS32985	COG0395	ABC-type sugar transport system, permease component
X994_RS32990	COG3842	ATPase activity
X994_RS32995	COG2860	membrane
X994_RS33000	COG1193	negative regulation of DNA recombination
X994_RS33005	COG0492	ferredoxin-NADP+ reductase activity
X994_RS33010	COG1674	ftsk spoiiie
X994_RS33015	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
X994_RS33025	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
X994_RS33060	COG2894	cell division
X994_RS33085	COG0859	PFAM glycosyl transferase family 9
X994_RS33095	COG0477	Major facilitator Superfamily
X994_RS33125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
X994_RS33130	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
X994_RS33140	COG1561	YicC-like family, N-terminal region
X994_RS33155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
X994_RS33175	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
X994_RS33185	COG1278	Cold shock
X994_RS33190	COG2176	DNA-directed DNA polymerase activity
X994_RS33210	COG4772	TonB-dependent receptor
X994_RS33260	COG0583	DNA-binding transcription factor activity
X994_RS33270	COG0308	aminopeptidase N
X994_RS33280	COG2119	membrane
X994_RS33290	COG0402	S-adenosylhomocysteine deaminase activity
X994_RS33295	COG2252	PERMEase
X994_RS33300	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
X994_RS33320	COG0154	amidase activity
X994_RS33325	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
X994_RS33350	COG3383	formate dehydrogenase (NAD+) activity
X994_RS33365	COG1910	domain protein
X994_RS33375	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
X994_RS33380	COG0546	phosphoglycolate phosphatase activity
X994_RS33405	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
X994_RS33410	COG1605	Chorismate mutase
X994_RS33410	COG0077	Prephenate dehydratase
X994_RS33415	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
X994_RS33440	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
X994_RS33450	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
X994_RS33475	COG2951	lytic endotransglycosylase activity
X994_RS33480	COG0123	including yeast histone deacetylase and acetoin utilization protein
X994_RS33485	COG2267	carboxylic ester hydrolase activity
X994_RS33495	COG2011	ABC-type metal ion transport system permease component
X994_RS33515	COG1960	acyl-CoA dehydrogenase activity
X994_RS33575	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
X994_RS33590	COG0501	Belongs to the peptidase M48B family
X994_RS33600	COG0521	Mo-molybdopterin cofactor biosynthetic process
X994_RS33605	COG3028	Belongs to the UPF0307 family
X994_RS33610	COG0312	modulator of DNA gyrase
X994_RS33615	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
X994_RS33620	COG2204	response regulator
X994_RS33650	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
X994_RS33660	COG0640	Transcriptional regulator
X994_RS33675	COG0114	fumarate hydratase activity
X994_RS33685	COG0534	Mate efflux family protein
X994_RS33690	COG2501	S4 domain
X994_RS33705	COG3045	CreA protein
X994_RS33720	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
X994_RS33725	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
X994_RS33745	COG1322	Protein conserved in bacteria
X994_RS33760	COG0303	'Molybdopterin
X994_RS33770	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
X994_RS33775	COG1530	ribonuclease E activity
X994_RS33785	COG0546	phosphoglycolate phosphatase activity
X994_RS33810	COG1399	metal-binding, possibly nucleic acid-binding protein
X994_RS33845	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
X994_RS33865	COG3026	antisigma factor binding