locus-tag	class	description
E4F35_RS00015	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4F35_RS00025	COG0735	belongs to the Fur family
E4F35_RS00035	COG1121	(ABC) transporter
E4F35_RS00040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4F35_RS00045	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4F35_RS00060	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4F35_RS00065	COG2233	PERMEase
E4F35_RS00080	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F35_RS00085	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4F35_RS00115	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4F35_RS00160	COG0009	L-threonylcarbamoyladenylate synthase
E4F35_RS00165	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4F35_RS00170	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4F35_RS00175	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4F35_RS00185	COG0469	pyruvate kinase activity
E4F35_RS00195	COG0126	phosphoglycerate kinase activity
E4F35_RS00220	COG0859	PFAM glycosyl transferase family 9
E4F35_RS00230	COG0429	hydrolase of the alpha beta-hydrolase fold
E4F35_RS00240	COG4783	chaperone-mediated protein folding
E4F35_RS00275	COG3307	-O-antigen
E4F35_RS00280	COG4969	Belongs to the N-Me-Phe pilin family
E4F35_RS00285	COG0861	Integral membrane protein TerC family
E4F35_RS00290	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4F35_RS00305	COG2137	regulation of response to DNA damage stimulus
E4F35_RS00310	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4F35_RS00340	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4F35_RS00370	COG0583	DNA-binding transcription factor activity
E4F35_RS00425	COG0784	Response regulator, receiver
E4F35_RS00425	COG5002	protein histidine kinase activity
E4F35_RS00430	COG0583	DNA-binding transcription factor activity
E4F35_RS00470	COG0028	Belongs to the TPP enzyme family
E4F35_RS00475	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4F35_RS00480	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4F35_RS00565	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E4F35_RS00570	COG0583	DNA-binding transcription factor activity
E4F35_RS00575	COG1301	dicarboxylic acid transport
E4F35_RS00590	COG0840	transmembrane signaling receptor activity
E4F35_RS00640	COG4948	Mandelate Racemase Muconate Lactonizing
E4F35_RS00670	COG0513	Belongs to the DEAD box helicase family
E4F35_RS00715	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4F35_RS00720	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4F35_RS00735	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4F35_RS00740	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4F35_RS00745	COG0367	asparagine synthase
E4F35_RS00760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4F35_RS00770	COG1396	sequence-specific DNA binding
E4F35_RS00775	COG2814	Major facilitator Superfamily
E4F35_RS00780	COG0583	DNA-binding transcription factor activity
E4F35_RS00795	COG1702	phosphate starvation-inducible protein PhoH
E4F35_RS00810	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
E4F35_RS00820	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4F35_RS00825	COG0752	glycyl-tRNA synthetase alpha subunit
E4F35_RS00830	COG0751	glycine-tRNA ligase activity
E4F35_RS00835	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4F35_RS00840	COG0204	Acyl-transferase
E4F35_RS00870	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4F35_RS00885	COG3178	'Phosphotransferase
E4F35_RS00890	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4F35_RS00900	COG5265	(ABC) transporter
E4F35_RS00920	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4F35_RS00925	COG1024	Enoyl-CoA hydratase
E4F35_RS00930	COG0183	Belongs to the thiolase family
E4F35_RS00935	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4F35_RS00935	COG1024	Enoyl-CoA hydratase
E4F35_RS00940	COG1960	acyl-CoA dehydrogenase activity
E4F35_RS00955	COG0494	nUDIX hydrolase
E4F35_RS01030	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4F35_RS01040	COG0251	oxidation-reduction process
E4F35_RS01045	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E4F35_RS01070	COG0477	Major facilitator Superfamily
E4F35_RS01115	COG1596	polysaccharide export
E4F35_RS01120	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4F35_RS01140	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4F35_RS01150	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4F35_RS01170	COG2204	response regulator
E4F35_RS01220	COG5001	Diguanylate cyclase
E4F35_RS01220	COG5002	protein histidine kinase activity
E4F35_RS01235	COG0235	Class ii aldolase
E4F35_RS01350	COG0629	single-stranded DNA binding
E4F35_RS01355	COG2814	Major facilitator Superfamily
E4F35_RS01390	COG1280	lysine exporter protein (LysE YggA)
E4F35_RS01415	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4F35_RS01430	COG1137	ATPase activity
E4F35_RS01435	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4F35_RS01445	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4F35_RS01470	COG1194	a g-specific adenine glycosylase
E4F35_RS01485	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E4F35_RS01500	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4F35_RS01510	COG0193	aminoacyl-tRNA hydrolase activity
E4F35_RS01520	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4F35_RS01535	COG0742	ribosomal rna small subunit methyltransferase
E4F35_RS01545	COG0625	glutathione transferase activity
E4F35_RS01555	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4F35_RS01565	COG0243	molybdopterin cofactor binding
E4F35_RS01570	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4F35_RS01585	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4F35_RS01595	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4F35_RS01605	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4F35_RS01620	COG1294	oxidase, subunit
E4F35_RS01650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4F35_RS01650	COG1263	PTS System
E4F35_RS01650	COG2190	(PTS) system
E4F35_RS01655	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4F35_RS01655	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4F35_RS01660	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4F35_RS01665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4F35_RS01670	COG2188	Transcriptional regulator
E4F35_RS01680	COG0583	DNA-binding transcription factor activity
E4F35_RS01725	COG0318	PFAM AMP-dependent synthetase and ligase
E4F35_RS01735	COG1960	acyl-CoA dehydrogenase activity
E4F35_RS01745	COG2226	methyltransferase
E4F35_RS01780	COG2814	Major facilitator Superfamily
E4F35_RS01790	COG0587	DNA-directed DNA polymerase activity
E4F35_RS01805	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4F35_RS01845	COG0840	transmembrane signaling receptor activity
E4F35_RS01860	COG1999	signal sequence binding
E4F35_RS01870	COG1612	heme a metabolic process
E4F35_RS01900	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E4F35_RS01910	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4F35_RS01925	COG2226	methyltransferase
E4F35_RS01930	COG1040	competence protein
E4F35_RS01945	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4F35_RS01965	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4F35_RS01975	COG0793	Belongs to the peptidase S41A family
E4F35_RS01980	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4F35_RS01990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4F35_RS01995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4F35_RS02005	COG0189	ligase activity
E4F35_RS02015	COG0004	ammonium transporteR
E4F35_RS02025	COG2960	long-chain fatty acid transporting porin activity
E4F35_RS02065	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4F35_RS02075	COG4191	Histidine kinase
E4F35_RS02090	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4F35_RS02100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4F35_RS02105	COG1960	acyl-CoA dehydrogenase activity
E4F35_RS02110	COG1960	acyl-CoA dehydrogenase activity
E4F35_RS02115	COG1024	Enoyl-CoA hydratase
E4F35_RS02115	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4F35_RS02120	COG0583	DNA-binding transcription factor activity
E4F35_RS02130	COG0405	Gamma-glutamyltransferase
E4F35_RS02155	COG0583	DNA-binding transcription factor activity
E4F35_RS02160	COG2921	Belongs to the UPF0250 family
E4F35_RS02170	COG1686	Belongs to the peptidase S11 family
E4F35_RS02205	COG1127	ABC transporter
E4F35_RS02210	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4F35_RS02215	COG0737	Belongs to the 5'-nucleotidase family
E4F35_RS02230	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E4F35_RS02240	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4F35_RS02265	COG1024	Enoyl-CoA hydratase
E4F35_RS02335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4F35_RS02340	COG4221	oxidoreductase activity
E4F35_RS02345	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS02365	COG0747	negative chemotaxis
E4F35_RS02370	COG0488	(ABC) transporter
E4F35_RS02390	COG0288	reversible hydration of carbon dioxide
E4F35_RS02395	COG0183	Belongs to the thiolase family
E4F35_RS02405	COG3012	SEC-C Motif Domain Protein
E4F35_RS02425	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4F35_RS02455	COG1785	Belongs to the alkaline phosphatase family
E4F35_RS02475	COG2199	diguanylate cyclase activity
E4F35_RS02475	COG2200	EAL domain
E4F35_RS02480	COG0025	NhaP-type Na H and K H
E4F35_RS02525	COG4650	regulator
E4F35_RS02555	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4F35_RS02575	COG1999	signal sequence binding
E4F35_RS02630	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4F35_RS02660	COG0596	Alpha beta hydrolase
E4F35_RS02675	COG0583	DNA-binding transcription factor activity
E4F35_RS02680	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS02705	COG0840	transmembrane signaling receptor activity
E4F35_RS02710	COG1609	Transcriptional regulator
E4F35_RS02770	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4F35_RS02790	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F35_RS02795	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4F35_RS02815	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4F35_RS02820	COG1704	LemA family
E4F35_RS02940	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS02960	COG2824	Alkylphosphonate utilization operon protein PhnA
E4F35_RS02990	COG0583	DNA-binding transcription factor activity
E4F35_RS03000	COG2233	PERMEase
E4F35_RS03010	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4F35_RS03020	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
E4F35_RS03030	COG1706	bacterial-type flagellum-dependent cell motility
E4F35_RS03035	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E4F35_RS03050	COG1749	Flagellar hook protein flgE
E4F35_RS03055	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4F35_RS03060	COG1558	bacterial-type flagellum-dependent cell motility
E4F35_RS03065	COG1815	bacterial-type flagellum-dependent cell motility
E4F35_RS03075	COG2747	anti-sigma28 factor FlgM
E4F35_RS03120	COG0741	lytic transglycosylase activity
E4F35_RS03125	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4F35_RS03140	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E4F35_RS03145	COG1984	allophanate hydrolase subunit 2
E4F35_RS03175	COG4608	Belongs to the ABC transporter superfamily
E4F35_RS03180	COG0444	Belongs to the ABC transporter superfamily
E4F35_RS03185	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4F35_RS03190	COG0601	transmembrane transport
E4F35_RS03195	COG0747	negative chemotaxis
E4F35_RS03215	COG0579	oxidoreductase
E4F35_RS03235	COG3568	Endonuclease Exonuclease Phosphatase
E4F35_RS03240	COG1280	lysine exporter protein (LysE YggA)
E4F35_RS03260	COG0531	amino acid
E4F35_RS03275	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4F35_RS03335	COG1960	acyl-CoA dehydrogenase activity
E4F35_RS03350	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4F35_RS03360	COG2814	Major facilitator Superfamily
E4F35_RS03380	COG0667	Aldo Keto reductase
E4F35_RS03410	COG1560	Kdo2-lipid A biosynthetic process
E4F35_RS03425	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E4F35_RS03435	COG0523	cobalamin synthesis protein
E4F35_RS03465	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E4F35_RS03495	COG1309	transcriptional regulator
E4F35_RS03510	COG2814	Major facilitator Superfamily
E4F35_RS03520	COG2207	Transcriptional regulator
E4F35_RS03525	COG1064	alcohol dehydrogenase
E4F35_RS03535	COG0708	Exodeoxyribonuclease III
E4F35_RS03540	COG2326	polyphosphate kinase activity
E4F35_RS03545	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4F35_RS03560	COG1077	Cell shape determining protein MreB Mrl
E4F35_RS03575	COG0768	penicillin binding
E4F35_RS03580	COG0772	Belongs to the SEDS family
E4F35_RS03600	COG0720	synthase
E4F35_RS03605	COG0602	queuosine metabolic process
E4F35_RS03625	COG2204	response regulator
E4F35_RS03630	COG5000	phosphorelay sensor kinase activity
E4F35_RS03660	COG0242	peptide deformylase activity
E4F35_RS03665	COG0758	DNA mediated transformation
E4F35_RS03685	COG0583	DNA-binding transcription factor activity
E4F35_RS03690	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4F35_RS03745	COG4695	Portal protein
E4F35_RS03760	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4F35_RS03775	COG0583	DNA-binding transcription factor activity
E4F35_RS03805	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4F35_RS03820	COG2169	Transcriptional regulator
E4F35_RS03820	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4F35_RS03850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4F35_RS03935	COG0582	viral genome integration into host DNA
E4F35_RS03975	COG0592	DNA-directed DNA polymerase activity
E4F35_RS04000	COG0753	catalase activity
E4F35_RS04045	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4F35_RS04050	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4F35_RS04050	COG1024	Enoyl-CoA hydratase
E4F35_RS04055	COG0183	Belongs to the thiolase family
E4F35_RS04065	COG1960	acyl-CoA dehydrogenase activity
E4F35_RS04100	COG1695	Transcriptional regulator
E4F35_RS04180	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS04205	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS04220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4F35_RS04230	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4F35_RS04240	COG4106	trans-aconitate 2-methyltransferase activity
E4F35_RS04240	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4F35_RS04245	COG0789	Transcriptional regulator
E4F35_RS04255	COG1987	bacterial-type flagellum assembly
E4F35_RS04270	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4F35_RS04290	COG1346	cytolysis
E4F35_RS04300	COG0583	DNA-binding transcription factor activity
E4F35_RS04305	COG2814	Major facilitator Superfamily
E4F35_RS04310	COG1846	Transcriptional regulator
E4F35_RS04325	COG2801	Transposase and inactivated derivatives
E4F35_RS04360	COG2165	general secretion pathway protein
E4F35_RS04380	COG1459	type II secretion system
E4F35_RS04405	COG0523	cobalamin synthesis protein
E4F35_RS04450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4F35_RS04450	COG0519	Catalyzes the synthesis of GMP from XMP
E4F35_RS04455	COG1902	pentaerythritol trinitrate reductase activity
E4F35_RS04475	COG0642	Histidine kinase
E4F35_RS04495	COG3186	Phenylalanine-4-hydroxylase
E4F35_RS04500	COG1522	sequence-specific DNA binding
E4F35_RS04515	COG0583	DNA-binding transcription factor activity
E4F35_RS04530	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E4F35_RS04560	COG0559	Belongs to the binding-protein-dependent transport system permease family
E4F35_RS04605	COG1192	Involved in chromosome partitioning
E4F35_RS04610	COG1475	DNA binding
E4F35_RS04615	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4F35_RS04625	COG0356	it plays a direct role in the translocation of protons across the membrane
E4F35_RS04665	COG0318	PFAM AMP-dependent synthetase and ligase
E4F35_RS04685	COG1832	CoA-binding protein
E4F35_RS04705	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4F35_RS04725	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4F35_RS04725	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4F35_RS04725	COG0506	proline dehydrogenase activity
E4F35_RS04740	COG1960	acyl-CoA dehydrogenase activity
E4F35_RS04760	COG0436	Aminotransferase
E4F35_RS04775	COG0277	FAD linked oxidase domain protein
E4F35_RS04785	COG0789	Transcriptional regulator
E4F35_RS04805	COG0668	transmembrane transport
E4F35_RS04825	COG0531	amino acid
E4F35_RS04835	COG4302	ethanolamine ammonia-lyase activity
E4F35_RS04845	COG1012	belongs to the aldehyde dehydrogenase family
E4F35_RS04875	COG1760	l-serine dehydratase
E4F35_RS04900	COG0509	glycine decarboxylation via glycine cleavage system
E4F35_RS04920	COG0673	inositol 2-dehydrogenase activity
E4F35_RS04940	COG0210	DNA helicase
E4F35_RS04945	COG3245	cytochrome
E4F35_RS04965	COG0582	viral genome integration into host DNA
E4F35_RS05010	COG3397	chitin binding
E4F35_RS05035	COG2267	carboxylic ester hydrolase activity
E4F35_RS05110	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS05125	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4F35_RS05165	COG0519	Catalyzes the synthesis of GMP from XMP
E4F35_RS05175	COG0561	phosphatase activity
E4F35_RS05180	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4F35_RS05195	COG0438	transferase activity, transferring glycosyl groups
E4F35_RS05220	COG1360	Flagellar Motor Protein
E4F35_RS05225	COG2201	protein-glutamate methylesterase activity
E4F35_RS05245	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4F35_RS05255	COG2201	protein-glutamate methylesterase activity
E4F35_RS05265	COG0745	RESPONSE REGULATOR receiver
E4F35_RS05270	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E4F35_RS05290	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4F35_RS05295	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4F35_RS05320	COG1950	PFAM Membrane protein of
E4F35_RS05325	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E4F35_RS05345	COG2070	2-Nitropropane dioxygenase
E4F35_RS05380	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4F35_RS05385	COG1522	sequence-specific DNA binding
E4F35_RS05395	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4F35_RS05420	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4F35_RS05425	COG2823	Periplasmic or secreted lipoprotein
E4F35_RS05440	COG1113	amino acid transport
E4F35_RS05485	COG2084	Dehydrogenase
E4F35_RS05490	COG1280	lysine exporter protein (LysE YggA)
E4F35_RS05500	COG0583	DNA-binding transcription factor activity
E4F35_RS05505	COG3047	cAMP biosynthetic process
E4F35_RS05525	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E4F35_RS05540	COG1881	PFAM PEBP family protein
E4F35_RS05545	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4F35_RS05555	COG0280	phosphate acetyltransferase
E4F35_RS05555	COG0281	malic enzyme
E4F35_RS05585	COG1522	sequence-specific DNA binding
E4F35_RS05605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4F35_RS05610	COG2151	metal-sulfur cluster biosynthetic enzyme
E4F35_RS05615	COG3396	Phenylacetate-CoA oxygenase
E4F35_RS05620	COG3460	Phenylacetate-CoA oxygenase
E4F35_RS05625	COG3396	Phenylacetate-CoA oxygenase
E4F35_RS05710	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4F35_RS05750	COG0514	ATP-dependent DNA helicase (RecQ)
E4F35_RS05885	COG0201	protein transport
E4F35_RS05930	COG4232	protein-disulfide reductase activity
E4F35_RS05950	COG1333	cytochrome c biogenesis protein
E4F35_RS05955	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4F35_RS05960	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E4F35_RS05965	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E4F35_RS06020	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E4F35_RS06030	COG1175	transmembrane transport
E4F35_RS06035	COG0395	ABC-type sugar transport system, permease component
E4F35_RS06040	COG3842	ATPase activity
E4F35_RS06045	COG0584	glycerophosphoryl diester phosphodiesterase
E4F35_RS06060	COG0067	glutamate synthase
E4F35_RS06060	COG0069	glutamate synthase activity
E4F35_RS06060	COG0070	glutamate synthase
E4F35_RS06075	COG1115	amino acid carrier protein
E4F35_RS06090	COG4178	(ABC) transporter
E4F35_RS06115	COG1127	ABC transporter
E4F35_RS06120	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4F35_RS06125	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4F35_RS06150	COG1131	(ABC) transporter
E4F35_RS06155	COG0842	Transport permease protein
E4F35_RS06180	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4F35_RS06190	COG2095	MarC family integral membrane protein
E4F35_RS06240	COG0805	protein transport
E4F35_RS06250	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4F35_RS06255	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4F35_RS06260	COG0723	plastoquinol--plastocyanin reductase activity
E4F35_RS06265	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E4F35_RS06270	COG2857	Cytochrome c1
E4F35_RS06275	COG0625	glutathione transferase activity
E4F35_RS06280	COG2969	positive regulation of protein catabolic process
E4F35_RS06295	COG0464	growth
E4F35_RS06305	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E4F35_RS06310	COG2801	Transposase and inactivated derivatives
E4F35_RS06480	COG0308	aminopeptidase N
E4F35_RS06565	COG0443	Heat shock 70 kDa protein
E4F35_RS06575	COG1278	Cold shock
E4F35_RS06580	COG0531	amino acid
E4F35_RS06585	COG3384	dioxygenase
E4F35_RS06595	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4F35_RS06600	COG2890	protein-(glutamine-N5) methyltransferase activity
E4F35_RS06630	COG0006	proline dipeptidase activity
E4F35_RS06635	COG1335	isochorismatase
E4F35_RS06650	COG0488	(ABC) transporter
E4F35_RS06665	COG0584	glycerophosphoryl diester phosphodiesterase
E4F35_RS06710	COG0012	GTP binding
E4F35_RS06740	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4F35_RS06745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4F35_RS06760	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E4F35_RS06780	COG0512	Glutamine amidotransferase of anthranilate synthase
E4F35_RS06795	COG0546	phosphoglycolate phosphatase activity
E4F35_RS06800	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4F35_RS06810	COG2967	ApaG domain
E4F35_RS06820	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E4F35_RS06830	COG2050	protein possibly involved in aromatic compounds catabolism
E4F35_RS06835	COG1024	Enoyl-CoA hydratase
E4F35_RS06840	COG0183	Belongs to the thiolase family
E4F35_RS06850	COG1024	Enoyl-CoA hydratase
E4F35_RS06900	COG0243	molybdopterin cofactor binding
E4F35_RS06905	COG0318	PFAM AMP-dependent synthetase and ligase
E4F35_RS06910	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS06925	COG0275	rRNA processing
E4F35_RS06930	COG3116	cell division
E4F35_RS06940	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4F35_RS06945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4F35_RS06980	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4F35_RS07000	COG0678	peroxiredoxin activity
E4F35_RS07025	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E4F35_RS07035	COG0494	nUDIX hydrolase
E4F35_RS07040	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E4F35_RS07065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4F35_RS07070	COG4536	flavin adenine dinucleotide binding
E4F35_RS07080	COG0142	geranyltranstransferase activity
E4F35_RS07135	COG2095	MarC family integral membrane protein
E4F35_RS07140	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E4F35_RS07145	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4F35_RS07200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4F35_RS07205	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E4F35_RS07215	COG2264	protein methyltransferase activity
E4F35_RS07220	COG0439	Biotin carboxylase
E4F35_RS07225	COG0511	ligase activity, forming carbon-carbon bonds
E4F35_RS07230	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E4F35_RS07235	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4F35_RS07245	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4F35_RS07250	COG3150	esterase
E4F35_RS07255	COG0557	exoribonuclease II activity
E4F35_RS07260	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4F35_RS07265	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4F35_RS07285	COG1414	Transcriptional regulator
E4F35_RS07290	COG3734	2-keto-3-deoxy-galactonokinase
E4F35_RS07300	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS07315	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F35_RS07320	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS07330	COG0284	orotidine-5'-phosphate decarboxylase activity
E4F35_RS07335	COG1546	Belongs to the CinA family
E4F35_RS07340	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4F35_RS07375	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4F35_RS07385	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E4F35_RS07390	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4F35_RS07395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4F35_RS07405	COG2814	Major facilitator Superfamily
E4F35_RS07420	COG0583	DNA-binding transcription factor activity
E4F35_RS07435	COG1301	dicarboxylic acid transport
E4F35_RS07440	COG4266	Belongs to the allantoicase family
E4F35_RS07445	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E4F35_RS07450	COG0735	belongs to the Fur family
E4F35_RS07455	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4F35_RS07485	COG1466	dna polymerase III delta subunit
E4F35_RS07490	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E4F35_RS07495	COG1981	membrane
E4F35_RS07510	COG1737	Transcriptional regulator
E4F35_RS07510	COG0837	glucose binding
E4F35_RS07525	COG0800	Aldolase
E4F35_RS07545	COG2223	nitrite transmembrane transporter activity
E4F35_RS07550	COG0583	DNA-binding transcription factor activity
E4F35_RS07560	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4F35_RS07565	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F35_RS07570	COG0765	amino acid transport
E4F35_RS07575	COG0765	amino acid transport
E4F35_RS07580	COG1126	abc transporter atp-binding protein
E4F35_RS07630	COG0121	glutamine amidotransferase
E4F35_RS07640	COG0418	dihydroorotase activity
E4F35_RS07680	COG1917	Cupin 2, conserved barrel domain protein
E4F35_RS07680	COG4977	sequence-specific DNA binding
E4F35_RS07685	COG0625	glutathione transferase activity
E4F35_RS07690	COG0625	glutathione transferase activity
E4F35_RS07705	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4F35_RS07715	COG0588	phosphoglycerate mutase activity
E4F35_RS07755	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E4F35_RS07760	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4F35_RS07765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4F35_RS07770	COG0006	proline dipeptidase activity
E4F35_RS07780	COG0625	glutathione transferase activity
E4F35_RS07785	COG0069	glutamate synthase activity
E4F35_RS07880	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4F35_RS07880	COG3008	intermembrane lipid transfer
E4F35_RS07885	COG2995	paraquat-inducible protein a
E4F35_RS07905	COG2353	YceI-like domain
E4F35_RS07910	COG2353	YceI-like domain
E4F35_RS07930	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4F35_RS07935	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4F35_RS07940	COG1862	Preprotein translocase
E4F35_RS07945	COG0343	queuine tRNA-ribosyltransferase activity
E4F35_RS07960	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4F35_RS07985	COG0783	Belongs to the Dps family
E4F35_RS08010	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E4F35_RS08015	COG2188	Transcriptional regulator
E4F35_RS08025	COG3624	Phosphonate C-P lyase system protein PhnG
E4F35_RS08035	COG3626	phosphonate metabolism
E4F35_RS08040	COG3627	carbon phosphorus lyase activity
E4F35_RS08045	COG4107	phosphonate C-P lyase system protein PhnK
E4F35_RS08050	COG4778	phosphonate C-P lyase system protein PhnL
E4F35_RS08055	COG3454	Phosphonate metabolism
E4F35_RS08060	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4F35_RS08065	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E4F35_RS08070	COG3639	organic phosphonate transmembrane transporter activity
E4F35_RS08090	COG0247	lactate metabolic process
E4F35_RS08095	COG0277	FAD linked oxidase domain protein
E4F35_RS08100	COG0277	FAD linked oxidase domain protein
E4F35_RS08105	COG0277	FAD linked oxidase domain protein
E4F35_RS08110	COG2096	Adenosyltransferase
E4F35_RS08115	COG1017	nitric oxide dioxygenase activity
E4F35_RS08115	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4F35_RS08125	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4F35_RS08135	COG0312	modulator of DNA gyrase
E4F35_RS08140	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4F35_RS08145	COG3164	Protein of unknown function
E4F35_RS08150	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E4F35_RS08155	COG0497	DNA recombination
E4F35_RS08160	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4F35_RS08200	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4F35_RS08210	COG1428	Deoxynucleoside kinase
E4F35_RS08215	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4F35_RS08220	COG0617	tRNA 3'-terminal CCA addition
E4F35_RS08230	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4F35_RS08260	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4F35_RS08265	COG0586	Pfam SNARE associated Golgi protein
E4F35_RS08365	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4F35_RS08380	COG1368	sulfuric ester hydrolase activity
E4F35_RS08385	COG0604	alcohol dehydrogenase
E4F35_RS08385	COG3321	synthase
E4F35_RS08385	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS08390	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E4F35_RS08395	COG0156	8-amino-7-oxononanoate synthase activity
E4F35_RS08445	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4F35_RS08450	COG0489	protein tyrosine kinase activity
E4F35_RS08450	COG3206	protein involved in exopolysaccharide biosynthesis
E4F35_RS08460	COG3562	capsule polysaccharide
E4F35_RS08465	COG1045	serine acetyltransferase
E4F35_RS08480	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E4F35_RS08485	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4F35_RS08490	COG0517	IMP dehydrogenase activity
E4F35_RS08490	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4F35_RS08525	COG2885	chlorophyll binding
E4F35_RS08550	COG0824	Thioesterase
E4F35_RS08555	COG4221	oxidoreductase activity
E4F35_RS08615	COG0450	alkyl hydroperoxide reductase
E4F35_RS08625	COG1960	acyl-CoA dehydrogenase activity
E4F35_RS08660	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4F35_RS08670	COG2814	Major facilitator Superfamily
E4F35_RS08700	COG2814	Major facilitator Superfamily
E4F35_RS08705	COG0778	Nitroreductase
E4F35_RS08715	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4F35_RS08720	COG0583	DNA-binding transcription factor activity
E4F35_RS08730	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4F35_RS08765	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4F35_RS08790	COG4774	siderophore transport
E4F35_RS08795	COG1120	ATPase activity
E4F35_RS08805	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4F35_RS08850	COG0730	response to heat
E4F35_RS08865	COG0584	glycerophosphoryl diester phosphodiesterase
E4F35_RS08875	COG1280	lysine exporter protein (LysE YggA)
E4F35_RS08935	COG0604	alcohol dehydrogenase
E4F35_RS08940	COG1733	regulation of RNA biosynthetic process
E4F35_RS08955	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4F35_RS08975	COG1773	rubredoxin
E4F35_RS08995	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E4F35_RS09070	COG1215	transferase activity, transferring glycosyl groups
E4F35_RS09085	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4F35_RS09100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4F35_RS09130	COG0859	PFAM glycosyl transferase family 9
E4F35_RS09185	COG1129	ABC transporter
E4F35_RS09195	COG0559	Belongs to the binding-protein-dependent transport system permease family
E4F35_RS09210	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4F35_RS09220	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E4F35_RS09230	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4F35_RS09270	COG2226	methyltransferase
E4F35_RS09300	COG0762	integral membrane protein
E4F35_RS09335	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4F35_RS09350	COG0436	Aminotransferase
E4F35_RS09380	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4F35_RS09380	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4F35_RS09405	COG2814	Major facilitator Superfamily
E4F35_RS09420	COG1126	abc transporter atp-binding protein
E4F35_RS09425	COG0765	amino acid transport
E4F35_RS09430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F35_RS09445	COG0363	glucosamine-6-phosphate deaminase activity
E4F35_RS09450	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E4F35_RS09460	COG1175	transmembrane transport
E4F35_RS09465	COG0395	ABC-type sugar transport system, permease component
E4F35_RS09470	COG3842	ATPase activity
E4F35_RS09475	COG2860	membrane
E4F35_RS09480	COG1193	negative regulation of DNA recombination
E4F35_RS09485	COG0492	ferredoxin-NADP+ reductase activity
E4F35_RS09490	COG1674	ftsk spoiiie
E4F35_RS09495	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4F35_RS09500	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4F35_RS09545	COG2894	cell division
E4F35_RS09565	COG0859	PFAM glycosyl transferase family 9
E4F35_RS09575	COG0477	Major facilitator Superfamily
E4F35_RS09610	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4F35_RS09615	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4F35_RS09625	COG1561	YicC-like family, N-terminal region
E4F35_RS09640	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4F35_RS09670	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS09680	COG1278	Cold shock
E4F35_RS09685	COG2176	DNA-directed DNA polymerase activity
E4F35_RS09705	COG4772	TonB-dependent receptor
E4F35_RS09765	COG0583	DNA-binding transcription factor activity
E4F35_RS09775	COG0308	aminopeptidase N
E4F35_RS09790	COG2119	membrane
E4F35_RS09800	COG0402	S-adenosylhomocysteine deaminase activity
E4F35_RS09805	COG2252	PERMEase
E4F35_RS09810	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4F35_RS09830	COG0154	amidase activity
E4F35_RS09840	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4F35_RS09880	COG3383	formate dehydrogenase (NAD+) activity
E4F35_RS09895	COG1910	domain protein
E4F35_RS09905	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4F35_RS09920	COG0546	phosphoglycolate phosphatase activity
E4F35_RS09950	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E4F35_RS09955	COG0077	Prephenate dehydratase
E4F35_RS09955	COG1605	Chorismate mutase
E4F35_RS09965	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4F35_RS09990	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E4F35_RS10000	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4F35_RS10025	COG2951	lytic endotransglycosylase activity
E4F35_RS10030	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4F35_RS10040	COG2267	carboxylic ester hydrolase activity
E4F35_RS10050	COG2011	ABC-type metal ion transport system permease component
E4F35_RS10070	COG1960	acyl-CoA dehydrogenase activity
E4F35_RS10155	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E4F35_RS10170	COG0501	Belongs to the peptidase M48B family
E4F35_RS10180	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4F35_RS10185	COG3028	Belongs to the UPF0307 family
E4F35_RS10195	COG0312	modulator of DNA gyrase
E4F35_RS10210	COG2204	response regulator
E4F35_RS10240	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E4F35_RS10250	COG0640	Transcriptional regulator
E4F35_RS10275	COG0114	fumarate hydratase activity
E4F35_RS10290	COG0534	Mate efflux family protein
E4F35_RS10295	COG2501	S4 domain
E4F35_RS10315	COG3045	CreA protein
E4F35_RS10330	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4F35_RS10340	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4F35_RS10360	COG1322	Protein conserved in bacteria
E4F35_RS10375	COG0303	'Molybdopterin
E4F35_RS10385	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4F35_RS10390	COG1530	ribonuclease E activity
E4F35_RS10405	COG0546	phosphoglycolate phosphatase activity
E4F35_RS10430	COG1399	metal-binding, possibly nucleic acid-binding protein
E4F35_RS10470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4F35_RS10490	COG3026	antisigma factor binding
E4F35_RS10495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4F35_RS10510	COG0681	Belongs to the peptidase S26 family
E4F35_RS10515	COG0571	ribonuclease III activity
E4F35_RS10520	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4F35_RS10545	COG2204	response regulator
E4F35_RS10565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4F35_RS10590	COG1956	GAF domain-containing protein
E4F35_RS10595	COG0583	DNA-binding transcription factor activity
E4F35_RS10610	COG2153	protein acetylation
E4F35_RS10625	COG1999	signal sequence binding
E4F35_RS10640	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E4F35_RS10645	COG1132	(ABC) transporter
E4F35_RS10650	COG0438	transferase activity, transferring glycosyl groups
E4F35_RS10665	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4F35_RS10670	COG0683	leucine binding
E4F35_RS10680	COG3511	phospholipase C
E4F35_RS10700	COG0596	Alpha beta hydrolase
E4F35_RS10710	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4F35_RS10725	COG3394	polysaccharide catabolic process
E4F35_RS10750	COG4598	ABC transporter
E4F35_RS10770	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4F35_RS10805	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F35_RS10815	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4F35_RS10845	COG1959	2 iron, 2 sulfur cluster binding
E4F35_RS10860	COG2151	metal-sulfur cluster biosynthetic enzyme
E4F35_RS10865	COG0822	iron-sulfur transferase activity
E4F35_RS10870	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4F35_RS10880	COG0396	ATPase activity
E4F35_RS10885	COG0719	Fe-S assembly protein
E4F35_RS10905	COG0840	transmembrane signaling receptor activity
E4F35_RS10910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4F35_RS10915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4F35_RS10940	COG0826	peptidase U32
E4F35_RS10945	COG0826	peptidase U32
E4F35_RS10950	COG3154	lipid carrier protein
E4F35_RS10995	COG2151	metal-sulfur cluster biosynthetic enzyme
E4F35_RS11015	COG0415	Belongs to the DNA photolyase family
E4F35_RS11020	COG0529	Catalyzes the synthesis of activated sulfate
E4F35_RS11070	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4F35_RS11085	COG0402	S-adenosylhomocysteine deaminase activity
E4F35_RS11125	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4F35_RS11130	COG0174	glutamine synthetase
E4F35_RS11160	COG0583	DNA-binding transcription factor activity
E4F35_RS11165	COG1960	acyl-CoA dehydrogenase activity
E4F35_RS11180	COG0477	Major facilitator Superfamily
E4F35_RS11190	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4F35_RS11190	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4F35_RS11195	COG1643	Atp-dependent helicase
E4F35_RS11220	COG1546	Belongs to the CinA family
E4F35_RS11220	COG1058	Belongs to the CinA family
E4F35_RS11235	COG0174	glutamine synthetase
E4F35_RS11260	COG2197	response regulator
E4F35_RS11265	COG4585	Histidine kinase
E4F35_RS11270	COG2181	nitrate reductase activity
E4F35_RS11275	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E4F35_RS11280	COG1140	nitrate reductase beta subunit
E4F35_RS11285	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E4F35_RS11290	COG2223	nitrite transmembrane transporter activity
E4F35_RS11315	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4F35_RS11320	COG0339	signal peptide processing
E4F35_RS11345	COG4566	intracellular signal transduction
E4F35_RS11355	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E4F35_RS11360	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4F35_RS11365	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4F35_RS11385	COG1414	Transcriptional regulator
E4F35_RS11410	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4F35_RS11420	COG1104	cysteine desulfurase activity
E4F35_RS11425	COG0822	iron-sulfur transferase activity
E4F35_RS11430	COG0316	Belongs to the HesB IscA family
E4F35_RS11450	COG2975	iron-sulfur cluster assembly
E4F35_RS11480	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4F35_RS11500	COG1136	(ABC) transporter
E4F35_RS11505	COG0084	hydrolase, TatD family'
E4F35_RS11510	COG2333	competence protein COMEC
E4F35_RS11510	COG0658	competence protein
E4F35_RS11515	COG2267	carboxylic ester hydrolase activity
E4F35_RS11535	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E4F35_RS11545	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4F35_RS11555	COG2833	Protein of unknown function (DUF455)
E4F35_RS11565	COG0596	Alpha beta hydrolase
E4F35_RS11575	COG0613	PHP domain protein
E4F35_RS11580	COG0009	L-threonylcarbamoyladenylate synthase
E4F35_RS11585	COG1994	Peptidase M50
E4F35_RS11590	COG0180	Tryptophanyl-tRNA synthetase
E4F35_RS11600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4F35_RS11605	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E4F35_RS11610	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4F35_RS11625	COG2850	peptidyl-arginine hydroxylation
E4F35_RS11940	COG3311	Transcriptional regulator
E4F35_RS12000	COG0483	inositol monophosphate 1-phosphatase activity
E4F35_RS12015	COG1045	serine acetyltransferase
E4F35_RS12025	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4F35_RS12035	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4F35_RS12060	COG0037	tRNA processing
E4F35_RS12070	COG0527	aspartate kinase activity
E4F35_RS12130	COG2895	sulfate adenylyltransferase (ATP) activity
E4F35_RS12130	COG0529	Catalyzes the synthesis of activated sulfate
E4F35_RS12160	COG2175	clavaminate synthase activity
E4F35_RS12180	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4F35_RS12185	COG3958	Transketolase
E4F35_RS12200	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E4F35_RS12220	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4F35_RS12240	COG0024	Methionine aminopeptidase
E4F35_RS12260	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4F35_RS12275	COG0243	molybdopterin cofactor binding
E4F35_RS12300	COG4166	transmembrane transport
E4F35_RS12305	COG4174	ABC transporter (Permease)
E4F35_RS12310	COG4239	(ABC) transporter, permease
E4F35_RS12315	COG4172	Belongs to the ABC transporter superfamily
E4F35_RS12325	COG0791	NLP P60 protein
E4F35_RS12330	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4F35_RS12395	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4F35_RS12405	COG0583	DNA-binding transcription factor activity
E4F35_RS12415	COG2224	Isocitrate lyase
E4F35_RS12425	COG0513	Belongs to the DEAD box helicase family
E4F35_RS12435	COG1214	PFAM Peptidase M22, glycoprotease
E4F35_RS12445	COG1573	uracil-dna glycosylase
E4F35_RS12460	COG0351	phosphomethylpyrimidine kinase
E4F35_RS12465	COG0477	Major facilitator Superfamily
E4F35_RS12485	COG0488	(ABC) transporter
E4F35_RS12490	COG0386	Belongs to the glutathione peroxidase family
E4F35_RS12505	COG2890	protein-(glutamine-N5) methyltransferase activity
E4F35_RS12515	COG1393	Belongs to the ArsC family
E4F35_RS12560	COG0242	peptide deformylase activity
E4F35_RS12565	COG1187	pseudouridine synthase activity
E4F35_RS12575	COG0024	Methionine aminopeptidase
E4F35_RS12605	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4F35_RS12620	COG0750	zinc metalloprotease
E4F35_RS12660	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4F35_RS12705	COG0330	HflC and HflK could
E4F35_RS12715	COG2867	negative regulation of translational initiation
E4F35_RS12725	COG0697	spore germination
E4F35_RS12800	COG1196	nuclear chromosome segregation
E4F35_RS12825	COG2814	Major facilitator Superfamily
E4F35_RS12865	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4F35_RS12875	COG1953	Uracil, thiamine, allantoin
E4F35_RS12890	COG3648	Uricase
E4F35_RS12890	COG3195	allantoin biosynthetic process
E4F35_RS12895	COG4266	Belongs to the allantoicase family
E4F35_RS12915	COG2351	hydroxyisourate hydrolase activity
E4F35_RS12930	COG0583	DNA-binding transcription factor activity
E4F35_RS12940	COG3360	Dodecin
E4F35_RS13035	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4F35_RS13050	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4F35_RS13185	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4F35_RS13195	COG1846	Transcriptional regulator
E4F35_RS13200	COG1929	Belongs to the glycerate kinase type-1 family
E4F35_RS13225	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4F35_RS13305	COG4181	ATPase activity
E4F35_RS13320	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4F35_RS13330	COG0047	phosphoribosylformylglycinamidine synthase activity
E4F35_RS13330	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4F35_RS13340	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4F35_RS13365	COG0318	PFAM AMP-dependent synthetase and ligase
E4F35_RS13375	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4F35_RS13375	COG1024	Enoyl-CoA hydratase
E4F35_RS13380	COG1335	isochorismatase
E4F35_RS13385	COG0183	Belongs to the thiolase family
E4F35_RS13415	COG2130	NADP-dependent
E4F35_RS13420	COG0657	acetylesterase activity
E4F35_RS13435	COG0354	folic acid binding
E4F35_RS13440	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4F35_RS13455	COG1247	-acetyltransferase
E4F35_RS13460	COG0084	hydrolase, TatD family'
E4F35_RS13490	COG0438	transferase activity, transferring glycosyl groups
E4F35_RS13525	COG0252	asparaginase activity
E4F35_RS13535	COG1652	LysM domain
E4F35_RS13545	COG2084	Dehydrogenase
E4F35_RS13550	COG3622	Belongs to the hyi family
E4F35_RS13555	COG3960	tartronate-semialdehyde synthase activity
E4F35_RS13560	COG0583	DNA-binding transcription factor activity
E4F35_RS13575	COG1595	DNA-templated transcription, initiation
E4F35_RS13620	COG0306	phosphate transporter
E4F35_RS13630	COG0791	NLP P60 protein
E4F35_RS13635	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E4F35_RS13645	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4F35_RS13650	COG0726	polysaccharide deacetylase
E4F35_RS13655	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4F35_RS13655	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4F35_RS13665	COG0463	Glycosyl transferase, family 2
E4F35_RS13670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4F35_RS13675	COG2076	Multidrug Resistance protein
E4F35_RS13680	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4F35_RS13690	COG0436	Aminotransferase
E4F35_RS13725	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E4F35_RS13730	COG0314	molybdopterin synthase activity
E4F35_RS13735	COG2346	COG2346, Truncated hemoglobins
E4F35_RS13740	COG1959	2 iron, 2 sulfur cluster binding
E4F35_RS13745	COG0542	response to heat
E4F35_RS13775	COG0534	Mate efflux family protein
E4F35_RS13795	COG3228	Belongs to the MtfA family
E4F35_RS13800	COG0477	Major facilitator Superfamily
E4F35_RS13805	COG0789	Transcriptional regulator
E4F35_RS13810	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4F35_RS13835	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4F35_RS13850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4F35_RS13895	COG0670	Belongs to the BI1 family
E4F35_RS13930	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4F35_RS13945	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4F35_RS13950	COG0330	HflC and HflK could
E4F35_RS13955	COG0330	HflC and HflK could
E4F35_RS13980	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E4F35_RS13995	COG3547	Transposase (IS116 IS110 IS902 family)
E4F35_RS14005	COG2183	response to ionizing radiation
E4F35_RS14020	COG1199	ATP-dependent helicase activity
E4F35_RS14035	COG0564	pseudouridine synthase activity
E4F35_RS14045	COG3243	poly(R)-hydroxyalkanoic acid synthase
E4F35_RS14050	COG0183	Belongs to the thiolase family
E4F35_RS14055	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS14080	COG0183	Belongs to the thiolase family
E4F35_RS14090	COG0626	cystathionine gamma-synthase activity
E4F35_RS14095	COG0560	Phosphoserine phosphatase
E4F35_RS14115	COG0390	transport system, permease component
E4F35_RS14120	COG1122	ATPase activity
E4F35_RS14125	COG2982	Protein involved in outer membrane biogenesis
E4F35_RS14135	COG0488	(ABC) transporter
E4F35_RS14155	COG2070	2-Nitropropane dioxygenase
E4F35_RS14160	COG3047	cAMP biosynthetic process
E4F35_RS14175	COG1914	H( )-stimulated, divalent metal cation uptake system
E4F35_RS14180	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4F35_RS14185	COG3842	ATPase activity
E4F35_RS14190	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F35_RS14195	COG1177	transmembrane transport
E4F35_RS14205	COG0730	response to heat
E4F35_RS14205	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4F35_RS14230	COG3655	Transcriptional regulator
E4F35_RS14255	COG1538	Outer membrane efflux protein
E4F35_RS14260	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F35_RS14275	COG0038	chloride channel
E4F35_RS14280	COG2855	membrane
E4F35_RS14300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4F35_RS14310	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4F35_RS14320	COG1609	Transcriptional regulator
E4F35_RS14410	COG0598	Magnesium transport protein CorA
E4F35_RS14455	COG1196	nuclear chromosome segregation
E4F35_RS14455	COG3264	Mechanosensitive ion channel
E4F35_RS14490	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E4F35_RS14505	COG4263	nitrous-oxide reductase activity
E4F35_RS14530	COG0840	transmembrane signaling receptor activity
E4F35_RS14540	COG2376	Dihydroxyacetone kinase
E4F35_RS14560	COG0475	glutathione-regulated potassium exporter activity
E4F35_RS14650	COG1414	Transcriptional regulator
E4F35_RS14675	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4F35_RS14705	COG2274	protein secretion by the type I secretion system
E4F35_RS14710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4F35_RS14720	COG0859	PFAM glycosyl transferase family 9
E4F35_RS14720	COG0457	Tetratricopeptide repeat
E4F35_RS14725	COG0529	Catalyzes the synthesis of activated sulfate
E4F35_RS14735	COG0745	RESPONSE REGULATOR receiver
E4F35_RS14765	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS14775	COG2986	histidine ammonia-lyase
E4F35_RS14785	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4F35_RS14800	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4F35_RS14825	COG1595	DNA-templated transcription, initiation
E4F35_RS14850	COG3220	belongs to the UPF0276 family
E4F35_RS14880	COG2192	nodulation
E4F35_RS14905	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4F35_RS14925	COG0165	Argininosuccinate lyase
E4F35_RS14930	COG0137	argininosuccinate synthase activity
E4F35_RS14945	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4F35_RS14955	COG3251	PFAM MbtH domain protein
E4F35_RS14975	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS14985	COG2207	Transcriptional regulator
E4F35_RS14995	COG0697	spore germination
E4F35_RS15000	COG0835	chemotaxis
E4F35_RS15030	COG0477	Major facilitator Superfamily
E4F35_RS15045	COG1732	Glycine betaine
E4F35_RS15050	COG1174	glycine betaine transport
E4F35_RS15055	COG1125	glycine betaine transport
E4F35_RS15060	COG1174	glycine betaine transport
E4F35_RS15085	COG2235	arginine
E4F35_RS15090	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4F35_RS15105	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS15115	COG0583	DNA-binding transcription factor activity
E4F35_RS15120	COG0625	glutathione transferase activity
E4F35_RS15140	COG1846	Transcriptional regulator
E4F35_RS15145	COG2807	transmembrane transport
E4F35_RS15150	COG1649	PFAM Uncharacterised BCR, COG1649
E4F35_RS15170	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E4F35_RS15180	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4F35_RS15200	COG3979	chitinase
E4F35_RS15220	COG0400	carboxylic ester hydrolase activity
E4F35_RS15225	COG4644	lycopene metabolic process
E4F35_RS15240	COG4974	Belongs to the 'phage' integrase family
E4F35_RS15275	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
E4F35_RS15305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4F35_RS15310	COG4774	siderophore transport
E4F35_RS15315	COG3486	L-lysine 6-monooxygenase (NADPH) activity
E4F35_RS15365	COG1120	ATPase activity
E4F35_RS15400	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS15405	COG1070	Carbohydrate kinase
E4F35_RS15410	COG1063	alcohol dehydrogenase
E4F35_RS15420	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F35_RS15425	COG1129	ABC transporter
E4F35_RS15430	COG1879	ABC-type sugar transport system periplasmic component
E4F35_RS15465	COG1132	(ABC) transporter
E4F35_RS15465	COG2375	cellular response to nickel ion
E4F35_RS15475	COG3121	Chaperone
E4F35_RS15485	COG3539	Fimbrial protein
E4F35_RS15515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F35_RS15525	COG1309	transcriptional regulator
E4F35_RS15535	COG0739	heme binding
E4F35_RS15540	COG0765	amino acid transport
E4F35_RS15545	COG4597	amino acid ABC transporter
E4F35_RS15560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F35_RS15605	COG4964	Belongs to the GSP D family
E4F35_RS15630	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4F35_RS15635	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E4F35_RS15650	COG0477	Major facilitator Superfamily
E4F35_RS15660	COG2719	SpoVR family
E4F35_RS15665	COG2718	Belongs to the UPF0229 family
E4F35_RS15670	COG2766	serine protein kinase
E4F35_RS15680	COG0840	transmembrane signaling receptor activity
E4F35_RS15685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4F35_RS15690	COG1609	Transcriptional regulator
E4F35_RS15695	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F35_RS15700	COG1129	ABC transporter
E4F35_RS15705	COG1879	ABC-type sugar transport system periplasmic component
E4F35_RS15710	COG0583	DNA-binding transcription factor activity
E4F35_RS15715	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4F35_RS15720	COG4208	sulfate ABC transporter
E4F35_RS15725	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4F35_RS15730	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4F35_RS15780	COG0701	Predicted permease
E4F35_RS15785	COG0667	Aldo Keto reductase
E4F35_RS15815	COG1301	dicarboxylic acid transport
E4F35_RS15860	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4F35_RS15925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F35_RS15930	COG0765	amino acid transport
E4F35_RS15935	COG0673	inositol 2-dehydrogenase activity
E4F35_RS15940	COG1802	Transcriptional regulator
E4F35_RS15950	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4F35_RS15960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4F35_RS15965	COG0557	exoribonuclease II activity
E4F35_RS15980	COG0840	transmembrane signaling receptor activity
E4F35_RS16010	COG0519	Catalyzes the synthesis of GMP from XMP
E4F35_RS16015	COG2814	Major facilitator Superfamily
E4F35_RS16025	COG0318	PFAM AMP-dependent synthetase and ligase
E4F35_RS16095	COG4964	Belongs to the GSP D family
E4F35_RS16155	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4F35_RS16160	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4F35_RS16165	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4F35_RS16170	COG0567	Dehydrogenase, E1 component
E4F35_RS16175	COG1217	gtp-binding protein TYPA
E4F35_RS16185	COG1846	Transcriptional regulator
E4F35_RS16195	COG1566	PFAM secretion protein HlyD family protein
E4F35_RS16200	COG2814	Major facilitator Superfamily
E4F35_RS16210	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4F35_RS16225	COG0195	Participates in both transcription termination and antitermination
E4F35_RS16225	COG2251	uridine kinase activity
E4F35_RS16235	COG1187	pseudouridine synthase activity
E4F35_RS16240	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4F35_RS16245	COG0583	DNA-binding transcription factor activity
E4F35_RS16305	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E4F35_RS16330	COG2755	lipolytic protein G-D-S-L family
E4F35_RS16330	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4F35_RS16345	COG0776	regulation of translation
E4F35_RS16370	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E4F35_RS16385	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4F35_RS16390	COG0251	oxidation-reduction process
E4F35_RS16395	COG2267	carboxylic ester hydrolase activity
E4F35_RS16405	COG0583	DNA-binding transcription factor activity
E4F35_RS16420	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS16475	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS16510	COG0477	Major facilitator Superfamily
E4F35_RS16535	COG1295	ribonuclease BN
E4F35_RS16550	COG0277	FAD linked oxidase domain protein
E4F35_RS16565	COG0583	DNA-binding transcription factor activity
E4F35_RS16600	COG0840	transmembrane signaling receptor activity
E4F35_RS16605	COG2223	nitrite transmembrane transporter activity
E4F35_RS16615	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4F35_RS16620	COG0210	DNA helicase
E4F35_RS16625	COG0525	valine-tRNA ligase activity
E4F35_RS16630	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4F35_RS16640	COG5002	protein histidine kinase activity
E4F35_RS16650	COG0745	RESPONSE REGULATOR receiver
E4F35_RS16660	COG0425	Belongs to the sulfur carrier protein TusA family
E4F35_RS16670	COG0673	inositol 2-dehydrogenase activity
E4F35_RS16675	COG0673	inositol 2-dehydrogenase activity
E4F35_RS16690	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F35_RS16705	COG3962	Belongs to the TPP enzyme family
E4F35_RS16715	COG3718	enzyme involved in inositol metabolism
E4F35_RS16725	COG0411	ABC transporter
E4F35_RS16735	COG0824	Thioesterase
E4F35_RS16760	COG2816	NAD+ diphosphatase activity
E4F35_RS16775	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4F35_RS16785	COG0477	Major facilitator Superfamily
E4F35_RS16810	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4F35_RS16820	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4F35_RS16830	COG0494	nUDIX hydrolase
E4F35_RS16855	COG1858	cytochrome C peroxidase
E4F35_RS16860	COG3511	phospholipase C
E4F35_RS16875	COG1566	PFAM secretion protein HlyD family protein
E4F35_RS16885	COG2814	Major facilitator Superfamily
E4F35_RS16890	COG1538	Outer membrane efflux protein
E4F35_RS16900	COG2197	response regulator
E4F35_RS16955	COG0583	DNA-binding transcription factor activity
E4F35_RS16965	COG2814	Major facilitator Superfamily
E4F35_RS17005	COG1914	H( )-stimulated, divalent metal cation uptake system
E4F35_RS17155	COG0457	Tetratricopeptide repeat
E4F35_RS17155	COG0859	PFAM glycosyl transferase family 9
E4F35_RS17205	COG0583	DNA-binding transcription factor activity
E4F35_RS17260	COG0366	Alpha amylase catalytic
E4F35_RS17265	COG0366	Alpha amylase catalytic
E4F35_RS17315	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E4F35_RS17380	COG4942	peptidase
E4F35_RS17385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4F35_RS17400	COG0534	Mate efflux family protein
E4F35_RS17480	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4F35_RS17495	COG0745	RESPONSE REGULATOR receiver
E4F35_RS17510	COG0581	inorganic phosphate transmembrane transporter activity
E4F35_RS17515	COG0573	inorganic phosphate transmembrane transporter activity
E4F35_RS17520	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4F35_RS17535	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4F35_RS17540	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4F35_RS17550	COG1534	Rna-binding protein
E4F35_RS17560	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4F35_RS17565	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4F35_RS17575	COG0505	Belongs to the CarA family
E4F35_RS17605	COG0741	lytic transglycosylase activity
E4F35_RS17605	COG1388	LysM domain
E4F35_RS17610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4F35_RS17615	COG2226	methyltransferase
E4F35_RS17620	COG0328	RNA-DNA hybrid ribonuclease activity
E4F35_RS17625	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4F35_RS17645	COG0477	Major facilitator Superfamily
E4F35_RS17675	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4F35_RS17685	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E4F35_RS17705	COG3052	prosthetic group binding
E4F35_RS17730	COG0583	DNA-binding transcription factor activity
E4F35_RS17740	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4F35_RS17745	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E4F35_RS17790	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F35_RS17830	COG0583	DNA-binding transcription factor activity
E4F35_RS17860	COG1522	sequence-specific DNA binding
E4F35_RS17935	COG1609	Transcriptional regulator
E4F35_RS17940	COG1840	ABC-type Fe3 transport system, periplasmic component
E4F35_RS17945	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4F35_RS17960	COG1177	transmembrane transport
E4F35_RS17970	COG3842	ATPase activity
E4F35_RS17980	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E4F35_RS18010	COG2814	Major facilitator Superfamily
E4F35_RS18020	COG0697	spore germination
E4F35_RS18035	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E4F35_RS18040	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
E4F35_RS18090	COG2200	EAL domain
E4F35_RS18100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4F35_RS18105	COG1074	ATP-dependent DNA helicase activity
E4F35_RS18110	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4F35_RS18120	COG1289	transmembrane transporter activity
E4F35_RS18145	COG1840	ABC-type Fe3 transport system, periplasmic component
E4F35_RS18150	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F35_RS18155	COG3842	ATPase activity
E4F35_RS18160	COG1522	sequence-specific DNA binding
E4F35_RS18180	COG1959	2 iron, 2 sulfur cluster binding
E4F35_RS18215	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F35_RS18220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F35_RS18260	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4F35_RS18275	COG2010	Cytochrome c
E4F35_RS18275	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4F35_RS18280	COG2863	cytochrome
E4F35_RS18315	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4F35_RS18335	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4F35_RS18350	COG0006	proline dipeptidase activity
E4F35_RS18425	COG2866	Carboxypeptidase
E4F35_RS18440	COG0436	Aminotransferase
E4F35_RS18450	COG1024	Enoyl-CoA hydratase
E4F35_RS18455	COG0588	phosphoglycerate mutase activity
E4F35_RS18465	COG1960	acyl-CoA dehydrogenase activity
E4F35_RS18485	COG1012	belongs to the aldehyde dehydrogenase family
E4F35_RS18485	COG2030	dehydratase
E4F35_RS18490	COG1960	acyl-CoA dehydrogenase activity
E4F35_RS18495	COG1960	acyl-CoA dehydrogenase activity
E4F35_RS18515	COG1007	ATP synthesis coupled electron transport
E4F35_RS18550	COG1034	ATP synthesis coupled electron transport
E4F35_RS18560	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E4F35_RS18595	COG0149	triose-phosphate isomerase activity
E4F35_RS18600	COG3321	synthase
E4F35_RS18600	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F35_RS18600	COG0604	alcohol dehydrogenase
E4F35_RS18600	COG4221	oxidoreductase activity
E4F35_RS18620	COG0683	leucine binding
E4F35_RS18635	COG0288	reversible hydration of carbon dioxide
E4F35_RS18640	COG0659	secondary active sulfate transmembrane transporter activity
E4F35_RS18650	COG1183	phosphatidylcholine synthase activity
E4F35_RS18670	COG0028	Belongs to the TPP enzyme family
E4F35_RS18705	COG0438	transferase activity, transferring glycosyl groups
E4F35_RS18725	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS18735	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4F35_RS18745	COG0154	amidase activity
E4F35_RS18755	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4F35_RS18790	COG0745	RESPONSE REGULATOR receiver
E4F35_RS18795	COG2205	protein histidine kinase activity
E4F35_RS18810	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E4F35_RS18815	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E4F35_RS18850	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS18870	COG0151	Belongs to the GarS family
E4F35_RS18885	COG0799	negative regulation of ribosome biogenesis
E4F35_RS18910	COG2233	PERMEase
E4F35_RS18965	COG1595	DNA-templated transcription, initiation
E4F35_RS18975	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4F35_RS19015	COG0859	PFAM glycosyl transferase family 9
E4F35_RS19020	COG0438	transferase activity, transferring glycosyl groups
E4F35_RS19060	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4F35_RS19070	COG0513	Belongs to the DEAD box helicase family
E4F35_RS19105	COG1674	ftsk spoiiie
E4F35_RS19110	COG2706	6-phosphogluconolactonase activity
E4F35_RS19120	COG3387	PFAM Glycoside hydrolase 15-related
E4F35_RS19130	COG1309	transcriptional regulator
E4F35_RS19135	COG2878	Part of a membrane complex involved in electron transport
E4F35_RS19140	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4F35_RS19180	COG3135	benzoate transporter
E4F35_RS19195	COG2764	glyoxalase bleomycin resistance protein dioxygenase
E4F35_RS19210	COG4106	trans-aconitate 2-methyltransferase activity
E4F35_RS19235	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F35_RS19245	COG0697	spore germination
E4F35_RS19250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F35_RS19295	COG0477	Major facilitator Superfamily
E4F35_RS19305	COG0583	DNA-binding transcription factor activity
E4F35_RS19320	COG0583	DNA-binding transcription factor activity
E4F35_RS19350	COG0488	(ABC) transporter
E4F35_RS19360	COG1773	rubredoxin
E4F35_RS19540	COG1881	PFAM PEBP family protein
E4F35_RS19545	COG2814	Major facilitator Superfamily
E4F35_RS19565	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E4F35_RS19595	COG1116	anion transmembrane transporter activity
E4F35_RS19600	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F35_RS19635	COG1741	Belongs to the pirin family
E4F35_RS19650	COG4215	(ABC) transporter
E4F35_RS19670	COG0347	Belongs to the P(II) protein family
E4F35_RS19690	COG1472	Belongs to the glycosyl hydrolase 3 family
E4F35_RS19700	COG2827	Endonuclease containing a URI domain
E4F35_RS19705	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4F35_RS19720	COG2271	Major facilitator Superfamily
E4F35_RS19755	COG2226	methyltransferase
E4F35_RS19795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4F35_RS19820	COG0489	protein tyrosine kinase activity
E4F35_RS19830	COG2885	chlorophyll binding
E4F35_RS19830	COG3047	cAMP biosynthetic process
E4F35_RS19860	COG2911	Protein conserved in bacteria
E4F35_RS19865	COG0729	surface antigen
E4F35_RS19875	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4F35_RS19895	COG0489	protein tyrosine kinase activity
E4F35_RS19900	COG2259	Doxx family
E4F35_RS19905	COG1492	cobalamin metabolic process
E4F35_RS19915	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E4F35_RS19925	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4F35_RS19945	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E4F35_RS19950	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E4F35_RS19955	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E4F35_RS19965	COG4206	TonB-dependent receptor
E4F35_RS20000	COG0583	DNA-binding transcription factor activity
E4F35_RS20015	COG4654	Cytochrome c, class I
E4F35_RS20035	COG0795	lipopolysaccharide-transporting ATPase activity
E4F35_RS20050	COG1648	precorrin-2 dehydrogenase activity
E4F35_RS20050	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4F35_RS20055	COG2895	sulfate adenylyltransferase (ATP) activity
E4F35_RS20065	COG0175	sulfate reduction
E4F35_RS20080	COG0583	DNA-binding transcription factor activity
E4F35_RS20095	COG1396	sequence-specific DNA binding
E4F35_RS20105	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4F35_RS20110	COG2258	MOSC domain
E4F35_RS20115	COG2267	carboxylic ester hydrolase activity
E4F35_RS20125	COG0583	DNA-binding transcription factor activity
E4F35_RS20135	COG1187	pseudouridine synthase activity
E4F35_RS20150	COG0543	2 iron, 2 sulfur cluster binding
E4F35_RS20150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4F35_RS20155	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4F35_RS20160	COG0456	acetyltransferase
E4F35_RS20200	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4F35_RS20205	COG1047	Peptidyl-prolyl cis-trans
E4F35_RS20225	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4F35_RS20250	COG3264	Mechanosensitive ion channel
E4F35_RS20250	COG1511	domain protein
E4F35_RS20255	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4F35_RS20255	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4F35_RS20260	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4F35_RS20265	COG0196	riboflavin kinase activity
E4F35_RS20270	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4F35_RS20300	COG1113	amino acid transport
E4F35_RS20305	COG0542	response to heat
E4F35_RS20315	COG1278	Cold shock
E4F35_RS20355	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4F35_RS20390	COG0656	L-ascorbic acid biosynthetic process
E4F35_RS20395	COG2188	Transcriptional regulator
E4F35_RS20415	COG2814	Major facilitator Superfamily
E4F35_RS20485	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4F35_RS20490	COG1570	exodeoxyribonuclease VII activity
E4F35_RS20500	COG1663	tetraacyldisaccharide 4'-kinase activity
E4F35_RS20540	COG0728	peptidoglycan biosynthetic process
E4F35_RS20560	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4F35_RS20580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4F35_RS20585	COG0318	PFAM AMP-dependent synthetase and ligase
E4F35_RS20590	COG4974	Belongs to the 'phage' integrase family
E4F35_RS20600	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4F35_RS20605	COG0802	atpase or kinase
E4F35_RS20610	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4F35_RS20625	COG1741	Belongs to the pirin family
E4F35_RS20630	COG3118	belongs to the thioredoxin family
E4F35_RS20640	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4F35_RS20650	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4F35_RS20660	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4F35_RS20670	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4F35_RS20675	COG1522	sequence-specific DNA binding
E4F35_RS20695	COG2271	Major facilitator Superfamily
E4F35_RS20705	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4F35_RS20710	COG1012	belongs to the aldehyde dehydrogenase family
E4F35_RS20720	COG0583	DNA-binding transcription factor activity
E4F35_RS20725	COG0246	Mannitol dehydrogenase
E4F35_RS20730	COG1070	Carbohydrate kinase
E4F35_RS20735	COG2390	Transcriptional regulator
E4F35_RS20750	COG0583	DNA-binding transcription factor activity
E4F35_RS20765	COG3842	ATPase activity
E4F35_RS20770	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4F35_RS20780	COG1175	transmembrane transport
E4F35_RS20795	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4F35_RS20800	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4F35_RS20845	COG3038	cytochrome b561
E4F35_RS20855	COG4774	siderophore transport
E4F35_RS20860	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E4F35_RS20875	COG3842	ATPase activity
E4F35_RS20885	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F35_RS20890	COG1177	transmembrane transport
E4F35_RS20950	COG2831	hemolysin activation secretion protein
E4F35_RS20955	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
E4F35_RS20955	COG3064	Membrane
E4F35_RS20955	COG3210	domain, Protein
E4F35_RS20960	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E4F35_RS20985	COG2188	Transcriptional regulator
E4F35_RS20995	COG2009	succinate dehydrogenase
E4F35_RS21005	COG1053	succinate dehydrogenase
E4F35_RS21010	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4F35_RS21015	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E4F35_RS21020	COG0372	Belongs to the citrate synthase family
E4F35_RS21050	COG1522	sequence-specific DNA binding
E4F35_RS21075	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4F35_RS21130	COG0135	phosphoribosylanthranilate isomerase activity
E4F35_RS21135	COG0133	tryptophan synthase activity
E4F35_RS21145	COG0159	tryptophan synthase activity
E4F35_RS21150	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4F35_RS21155	COG0285	dihydrofolate synthase activity
E4F35_RS21190	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4F35_RS21195	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E4F35_RS21200	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4F35_RS21200	COG2755	lipolytic protein G-D-S-L family
E4F35_RS21220	COG0438	transferase activity, transferring glycosyl groups
E4F35_RS21235	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4F35_RS21245	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4F35_RS21245	COG2755	lipolytic protein G-D-S-L family
E4F35_RS21270	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS21275	COG1295	ribonuclease BN
E4F35_RS21295	COG3608	succinylglutamate desuccinylase aspartoacylase
E4F35_RS21315	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F35_RS21325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4F35_RS21330	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4F35_RS21335	COG1126	abc transporter atp-binding protein
E4F35_RS21345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F35_RS21370	COG0437	4 iron, 4 sulfur cluster binding
E4F35_RS21375	COG2864	formate dehydrogenase
E4F35_RS21385	COG1921	L-seryl-tRNASec selenium transferase activity
E4F35_RS21390	COG3276	selenocysteine insertion sequence binding
E4F35_RS21410	COG0154	amidase activity
E4F35_RS21420	COG1472	Belongs to the glycosyl hydrolase 3 family
E4F35_RS21465	COG3621	Patatin-like phospholipase
E4F35_RS21505	COG4191	Histidine kinase
E4F35_RS21515	COG2814	Major facilitator Superfamily
E4F35_RS21535	COG0583	DNA-binding transcription factor activity
E4F35_RS21545	COG2030	dehydratase
E4F35_RS21550	COG0427	acetyl-CoA hydrolase
E4F35_RS21555	COG0028	Belongs to the TPP enzyme family
E4F35_RS21660	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4F35_RS21665	COG4789	Type iii secretion
E4F35_RS21680	COG4790	Type iii secretion
E4F35_RS21685	COG4794	Type iii secretion
E4F35_RS21720	COG2207	Transcriptional regulator
E4F35_RS21770	COG1450	Type ii and iii secretion system protein
E4F35_RS21900	COG3550	peptidyl-serine autophosphorylation
E4F35_RS21915	COG1215	transferase activity, transferring glycosyl groups
E4F35_RS21920	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
E4F35_RS21925	COG0457	Tetratricopeptide repeat
E4F35_RS21945	COG1215	transferase activity, transferring glycosyl groups
E4F35_RS21950	COG2194	sulfuric ester hydrolase activity
E4F35_RS21960	COG2175	clavaminate synthase activity
E4F35_RS21970	COG4521	taurine ABC transporter
E4F35_RS21980	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4F35_RS22010	COG0318	PFAM AMP-dependent synthetase and ligase
E4F35_RS22030	COG0306	phosphate transporter
E4F35_RS22045	COG1522	sequence-specific DNA binding
E4F35_RS22050	COG1280	lysine exporter protein (LysE YggA)
E4F35_RS22085	COG0477	Major facilitator Superfamily
E4F35_RS22235	COG4790	Type iii secretion
E4F35_RS22270	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4F35_RS22285	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4F35_RS22370	COG0302	gtp cyclohydrolase
E4F35_RS22510	COG5295	Hep Hag repeat protein
E4F35_RS22520	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4F35_RS22555	COG5564	TIM-barrel signal transduction protein
E4F35_RS22560	COG5441	Belongs to the UPF0261 family
E4F35_RS22600	COG1063	alcohol dehydrogenase
E4F35_RS22605	COG4948	Mandelate Racemase Muconate Lactonizing
E4F35_RS22615	COG0246	Mannitol dehydrogenase
E4F35_RS22625	COG2271	Major facilitator Superfamily
E4F35_RS22635	COG1349	DNA-binding transcription factor activity
E4F35_RS22660	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4F35_RS22675	COG0583	DNA-binding transcription factor activity
E4F35_RS22690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F35_RS22695	COG1012	belongs to the aldehyde dehydrogenase family
E4F35_RS22700	COG1477	protein flavinylation
E4F35_RS22750	COG2271	Major facilitator Superfamily
E4F35_RS22790	COG4638	Rieske (2fe-2S)
E4F35_RS22840	COG1960	acyl-CoA dehydrogenase activity
E4F35_RS22845	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4F35_RS22885	COG5295	Hep Hag repeat protein
E4F35_RS22885	COG5295	Hep Hag repeat protein
E4F35_RS22910	COG0798	PFAM Bile acid sodium symporter
E4F35_RS22925	COG0640	Transcriptional regulator
E4F35_RS22960	COG4175	Glycine betaine
E4F35_RS23010	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4F35_RS23015	COG3622	Belongs to the hyi family
E4F35_RS23020	COG2271	Major facilitator Superfamily
E4F35_RS23025	COG0235	Class ii aldolase
E4F35_RS23030	COG3395	kinase activity
E4F35_RS23035	COG2084	Dehydrogenase
E4F35_RS23040	COG2186	Transcriptional regulator
E4F35_RS23120	COG4789	Type iii secretion
E4F35_RS23125	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4F35_RS23170	COG2207	Transcriptional regulator
E4F35_RS23175	COG1450	Type ii and iii secretion system protein
E4F35_RS23210	COG4644	lycopene metabolic process
E4F35_RS23220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4F35_RS23250	COG1285	pathogenesis
E4F35_RS23265	COG1271	oxidase subunit
E4F35_RS23270	COG1294	oxidase, subunit
E4F35_RS23310	COG1760	l-serine dehydratase
E4F35_RS23330	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4F35_RS23330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4F35_RS23370	COG1278	Cold shock
E4F35_RS23400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4F35_RS23415	COG4251	negative regulation of phosphorylation
E4F35_RS23420	COG0784	Response regulator, receiver
E4F35_RS23430	COG0477	Major facilitator Superfamily
E4F35_RS23485	COG2814	Major facilitator Superfamily
E4F35_RS23510	COG1566	PFAM secretion protein HlyD family protein
E4F35_RS23520	COG1505	serine-type exopeptidase activity
E4F35_RS23535	COG1045	serine acetyltransferase
E4F35_RS23545	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4F35_RS23550	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4F35_RS23555	COG3038	cytochrome b561
E4F35_RS23565	COG0640	Transcriptional regulator
E4F35_RS23570	COG2391	methyltransferase activity
E4F35_RS23580	COG0454	-acetyltransferase
E4F35_RS23580	COG0456	acetyltransferase
E4F35_RS23605	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E4F35_RS23610	COG1858	cytochrome C peroxidase
E4F35_RS23625	COG2814	Major facilitator Superfamily
E4F35_RS23630	COG2188	Transcriptional regulator
E4F35_RS23685	COG0277	FAD linked oxidase domain protein
E4F35_RS23695	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4F35_RS23705	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4F35_RS23750	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4F35_RS23760	COG1446	asparaginase
E4F35_RS23765	COG4172	Belongs to the ABC transporter superfamily
E4F35_RS23775	COG0747	negative chemotaxis
E4F35_RS23780	COG0601	transmembrane transport
E4F35_RS23785	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4F35_RS23800	COG3485	protocatechuate 3,4-dioxygenase
E4F35_RS23805	COG3485	protocatechuate 3,4-dioxygenase
E4F35_RS23810	COG0583	DNA-binding transcription factor activity
E4F35_RS23830	COG2203	Gaf domain
E4F35_RS23830	COG5001	Diguanylate cyclase
E4F35_RS23830	COG3706	GGDEF domain
E4F35_RS23830	COG4251	negative regulation of phosphorylation
E4F35_RS23840	COG4122	O-methyltransferase activity
E4F35_RS23845	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4F35_RS23865	COG0531	amino acid
E4F35_RS23875	COG1201	RNA secondary structure unwinding
E4F35_RS23925	COG2274	protein secretion by the type I secretion system
E4F35_RS23965	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4F35_RS23995	COG1739	Uncharacterized protein family UPF0029
E4F35_RS24030	COG0318	PFAM AMP-dependent synthetase and ligase
E4F35_RS24070	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F35_RS24135	COG1979	alcohol dehydrogenase
E4F35_RS24140	COG2130	NADP-dependent
E4F35_RS24175	COG0583	DNA-binding transcription factor activity
E4F35_RS24190	COG0583	DNA-binding transcription factor activity
E4F35_RS24195	COG0477	Major facilitator Superfamily
E4F35_RS24235	COG0302	gtp cyclohydrolase
E4F35_RS24245	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4F35_RS24245	COG1116	anion transmembrane transporter activity
E4F35_RS24250	COG3707	response regulator
E4F35_RS24270	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4F35_RS24275	COG2146	nitrite reductase [NAD(P)H] activity
E4F35_RS24280	COG0243	molybdopterin cofactor binding
E4F35_RS24305	COG1070	Carbohydrate kinase
E4F35_RS24315	COG3842	ATPase activity
E4F35_RS24320	COG1063	alcohol dehydrogenase
E4F35_RS24365	COG2223	nitrite transmembrane transporter activity
E4F35_RS24370	COG1349	DNA-binding transcription factor activity
E4F35_RS24425	COG4651	solute:proton antiporter activity
E4F35_RS24425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4F35_RS24430	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS24455	COG0840	transmembrane signaling receptor activity
E4F35_RS24475	COG0352	thiamine-phosphate diphosphorylase activity
E4F35_RS24480	COG0477	Major facilitator Superfamily
E4F35_RS24560	COG0540	Belongs to the ATCase OTCase family
E4F35_RS24580	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4F35_RS24640	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4F35_RS24645	COG0318	PFAM AMP-dependent synthetase and ligase
E4F35_RS24705	COG0475	glutathione-regulated potassium exporter activity
E4F35_RS24725	COG0339	signal peptide processing
E4F35_RS24730	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F35_RS24755	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E4F35_RS24775	COG2175	clavaminate synthase activity
E4F35_RS24800	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4F35_RS24825	COG3851	Histidine kinase
E4F35_RS24835	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E4F35_RS24840	COG1140	nitrate reductase beta subunit
E4F35_RS24845	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E4F35_RS24850	COG2181	nitrate reductase activity
E4F35_RS24855	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4F35_RS24895	COG0651	ATP synthesis coupled electron transport
E4F35_RS24900	COG0650	Formate hydrogenlyase subunit 4
E4F35_RS24910	COG0651	ATP synthesis coupled electron transport
E4F35_RS24915	COG0649	NAD binding
E4F35_RS24920	COG3260	NADH ubiquinone oxidoreductase 20
E4F35_RS24970	COG1695	Transcriptional regulator
E4F35_RS24975	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4F35_RS24975	COG1902	pentaerythritol trinitrate reductase activity
E4F35_RS25020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4F35_RS25020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4F35_RS25025	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4F35_RS25040	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4F35_RS25055	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F35_RS25060	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4F35_RS25120	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4F35_RS25165	COG2264	protein methyltransferase activity
E4F35_RS25215	COG0443	Heat shock 70 kDa protein
E4F35_RS25220	COG0443	Heat shock 70 kDa protein
E4F35_RS25260	COG0686	Belongs to the AlaDH PNT family
E4F35_RS25345	COG2271	Major facilitator Superfamily
E4F35_RS25355	COG1960	acyl-CoA dehydrogenase activity
E4F35_RS25390	COG1129	ABC transporter
E4F35_RS25395	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F35_RS25400	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F35_RS25405	COG4774	siderophore transport
E4F35_RS25410	COG3712	iron ion homeostasis
E4F35_RS25415	COG1595	DNA-templated transcription, initiation
E4F35_RS25460	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4F35_RS25505	COG2842	Transposition protein
E4F35_RS25535	COG0776	regulation of translation
E4F35_RS25605	COG4386	tail sheath protein
E4F35_RS25680	COG2353	YceI-like domain
E4F35_RS25710	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4F35_RS25735	COG0387	Pfam Sodium calcium exchanger
E4F35_RS25745	COG0583	DNA-binding transcription factor activity
E4F35_RS25785	COG4221	oxidoreductase activity
E4F35_RS25785	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4F35_RS25785	COG0300	oxidoreductase activity
E4F35_RS25785	COG3321	synthase
E4F35_RS25790	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS25790	COG0318	PFAM AMP-dependent synthetase and ligase
E4F35_RS25790	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F35_RS25790	COG3321	synthase
E4F35_RS25790	COG0300	oxidoreductase activity
E4F35_RS25795	COG4221	oxidoreductase activity
E4F35_RS25795	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4F35_RS25795	COG0300	oxidoreductase activity
E4F35_RS25795	COG3321	synthase
E4F35_RS25800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F35_RS25800	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS25800	COG3321	synthase
E4F35_RS25800	COG4221	oxidoreductase activity
E4F35_RS25810	COG0475	glutathione-regulated potassium exporter activity
E4F35_RS25810	COG0569	domain protein
E4F35_RS25815	COG2070	2-Nitropropane dioxygenase
E4F35_RS25815	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4F35_RS25820	COG3547	Transposase (IS116 IS110 IS902 family)
E4F35_RS25840	COG3425	synthase
E4F35_RS25845	COG1024	Enoyl-CoA hydratase
E4F35_RS25850	COG1024	Enoyl-CoA hydratase
E4F35_RS25855	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4F35_RS25860	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4F35_RS25880	COG2207	Transcriptional regulator
E4F35_RS25885	COG0500	methyltransferase
E4F35_RS25910	COG3275	phosphorelay sensor kinase activity
E4F35_RS25965	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4F35_RS25975	COG4160	amino acid transport
E4F35_RS26000	COG2259	Doxx family
E4F35_RS26025	COG1404	Belongs to the peptidase S8 family
E4F35_RS26050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F35_RS26055	COG0243	molybdopterin cofactor binding
E4F35_RS26060	COG3781	membrane
E4F35_RS26065	COG4682	membrane
E4F35_RS26075	COG1914	H( )-stimulated, divalent metal cation uptake system
E4F35_RS26080	COG2140	Oxalate decarboxylase
E4F35_RS26125	COG3209	COG3209 Rhs family protein
E4F35_RS26160	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
E4F35_RS26170	COG0601	transmembrane transport
E4F35_RS26175	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4F35_RS26200	COG0583	DNA-binding transcription factor activity
E4F35_RS26235	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS26285	COG0596	Alpha beta hydrolase
E4F35_RS26290	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4F35_RS26310	COG0840	transmembrane signaling receptor activity
E4F35_RS26335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4F35_RS26365	COG0596	Alpha beta hydrolase
E4F35_RS26445	COG1522	sequence-specific DNA binding
E4F35_RS26455	COG0154	amidase activity
E4F35_RS26485	COG0477	Major facilitator Superfamily
E4F35_RS26500	COG1012	belongs to the aldehyde dehydrogenase family
E4F35_RS26510	COG0028	Belongs to the TPP enzyme family
E4F35_RS26515	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS26520	COG1414	Transcriptional regulator
E4F35_RS26550	COG2146	nitrite reductase [NAD(P)H] activity
E4F35_RS26560	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS26565	COG1414	Transcriptional regulator
E4F35_RS26580	COG1408	metallophosphoesterase
E4F35_RS26590	COG1285	pathogenesis
E4F35_RS26595	COG2197	response regulator
E4F35_RS26620	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4F35_RS26625	COG0516	GMP reductase activity
E4F35_RS26625	COG0517	IMP dehydrogenase activity
E4F35_RS26640	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4F35_RS26645	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS26665	COG1902	pentaerythritol trinitrate reductase activity
E4F35_RS26685	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS26700	COG0531	amino acid
E4F35_RS26705	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4F35_RS26710	COG1012	belongs to the aldehyde dehydrogenase family
E4F35_RS26745	COG0583	DNA-binding transcription factor activity
E4F35_RS26755	COG0583	DNA-binding transcription factor activity
E4F35_RS26800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4F35_RS26855	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4F35_RS26870	COG1113	amino acid transport
E4F35_RS26885	COG4221	oxidoreductase activity
E4F35_RS26925	COG0589	response to stress
E4F35_RS27000	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4F35_RS27015	COG3291	Pkd domain containing protein
E4F35_RS27035	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4F35_RS27040	COG2175	clavaminate synthase activity
E4F35_RS27055	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E4F35_RS27060	COG0495	leucyl-tRNA aminoacylation
E4F35_RS27090	COG2373	Large extracellular alpha-helical protein
E4F35_RS27100	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4F35_RS27110	COG2201	protein-glutamate methylesterase activity
E4F35_RS27115	COG4191	Histidine kinase
E4F35_RS27115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F35_RS27175	COG1448	Aminotransferase
E4F35_RS27190	COG1522	sequence-specific DNA binding
E4F35_RS27210	COG1272	protein, Hemolysin III
E4F35_RS27265	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4F35_RS27275	COG5295	Hep Hag repeat protein
E4F35_RS27275	COG5295	Hep Hag repeat protein
E4F35_RS27300	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS27310	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS27325	COG2721	sulfolactate sulfo-lyase activity
E4F35_RS27335	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F35_RS27340	COG1129	ABC transporter
E4F35_RS27365	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS27375	COG2814	Major facilitator Superfamily
E4F35_RS27380	COG3320	Male sterility
E4F35_RS27380	COG1022	Amp-dependent synthetase and ligase
E4F35_RS27385	COG1012	belongs to the aldehyde dehydrogenase family
E4F35_RS27390	COG1024	Enoyl-CoA hydratase
E4F35_RS27465	COG2197	response regulator
E4F35_RS27485	COG3511	phospholipase C
E4F35_RS27490	COG1858	cytochrome C peroxidase
E4F35_RS27535	COG0402	S-adenosylhomocysteine deaminase activity
E4F35_RS27540	COG2508	Transcriptional regulator
E4F35_RS27545	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4F35_RS27560	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS27585	COG0583	DNA-binding transcription factor activity
E4F35_RS27630	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS27735	COG1215	transferase activity, transferring glycosyl groups
E4F35_RS27745	COG0840	transmembrane signaling receptor activity
E4F35_RS27755	COG0318	PFAM AMP-dependent synthetase and ligase
E4F35_RS27790	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS27800	COG0628	permease
E4F35_RS27815	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4F35_RS27830	COG1902	pentaerythritol trinitrate reductase activity
E4F35_RS27850	COG1309	transcriptional regulator
E4F35_RS27885	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
E4F35_RS27890	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4F35_RS27915	COG1024	Enoyl-CoA hydratase
E4F35_RS27935	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS27945	COG3217	Mosc domain protein beta barrel domain protein
E4F35_RS27945	COG0633	Ferredoxin
E4F35_RS27955	COG0642	Histidine kinase
E4F35_RS27970	COG4208	sulfate ABC transporter
E4F35_RS27975	COG3842	ATPase activity
E4F35_RS27990	COG2207	Transcriptional regulator
E4F35_RS28000	COG3971	2-oxopent-4-enoate hydratase activity
E4F35_RS28010	COG3384	dioxygenase
E4F35_RS28015	COG1012	belongs to the aldehyde dehydrogenase family
E4F35_RS28030	COG1846	Transcriptional regulator
E4F35_RS28045	COG0745	RESPONSE REGULATOR receiver
E4F35_RS28050	COG2205	protein histidine kinase activity
E4F35_RS28100	COG2207	Transcriptional regulator
E4F35_RS28160	COG1845	cytochrome c oxidase, subunit III
E4F35_RS28180	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E4F35_RS28190	COG0477	Major facilitator Superfamily
E4F35_RS28200	COG3214	Protein conserved in bacteria
E4F35_RS28220	COG3291	Pkd domain containing protein
E4F35_RS28365	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4F35_RS28395	COG0642	Histidine kinase
E4F35_RS28480	COG2205	protein histidine kinase activity
E4F35_RS28485	COG0745	RESPONSE REGULATOR receiver
E4F35_RS28495	COG2066	Belongs to the glutaminase family
E4F35_RS28525	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4F35_RS28535	COG1538	Outer membrane efflux protein
E4F35_RS28545	COG1024	Enoyl-CoA hydratase
E4F35_RS28550	COG1024	Enoyl-CoA hydratase
E4F35_RS28565	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4F35_RS28570	COG1960	acyl-CoA dehydrogenase activity
E4F35_RS28585	COG0330	HflC and HflK could
E4F35_RS28620	COG0028	Belongs to the TPP enzyme family
E4F35_RS28620	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E4F35_RS28630	COG1012	belongs to the aldehyde dehydrogenase family
E4F35_RS28675	COG2252	PERMEase
E4F35_RS28700	COG3284	Transcriptional regulator
E4F35_RS28740	COG1132	(ABC) transporter
E4F35_RS28760	COG3547	Transposase (IS116 IS110 IS902 family)
E4F35_RS28770	COG3433	isochorismatase activity
E4F35_RS28770	COG2226	methyltransferase
E4F35_RS28770	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F35_RS28780	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4F35_RS28875	COG0657	acetylesterase activity
E4F35_RS28885	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4F35_RS28890	COG3246	L-lysine catabolic process to acetate
E4F35_RS28930	COG3119	arylsulfatase activity
E4F35_RS28935	COG0583	DNA-binding transcription factor activity
E4F35_RS28950	COG2113	Glycine betaine
E4F35_RS28970	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E4F35_RS28975	COG2181	nitrate reductase activity
E4F35_RS28975	COG0247	lactate metabolic process
E4F35_RS28980	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4F35_RS28980	COG1902	pentaerythritol trinitrate reductase activity
E4F35_RS29025	COG1621	beta-fructofuranosidase activity
E4F35_RS29035	COG1566	PFAM secretion protein HlyD family protein
E4F35_RS29060	COG2814	Major facilitator Superfamily
E4F35_RS29225	COG0028	Belongs to the TPP enzyme family
E4F35_RS29225	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E4F35_RS29230	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4F35_RS29240	COG4977	sequence-specific DNA binding
E4F35_RS29260	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F35_RS29265	COG1305	Transglutaminase-like
E4F35_RS29295	COG2308	Evidence 4 Homologs of previously reported genes of
E4F35_RS29305	COG0778	Nitroreductase
E4F35_RS29330	COG3634	alkyl hydroperoxide reductase activity
E4F35_RS29360	COG0318	PFAM AMP-dependent synthetase and ligase
E4F35_RS29380	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4F35_RS29415	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4F35_RS29425	COG0010	Belongs to the arginase family
E4F35_RS29430	COG1012	belongs to the aldehyde dehydrogenase family
E4F35_RS29435	COG1396	sequence-specific DNA binding
E4F35_RS29435	COG1917	Cupin 2, conserved barrel domain protein
E4F35_RS29450	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4F35_RS29455	COG0174	glutamine synthetase
E4F35_RS29470	COG3842	ATPase activity
E4F35_RS29475	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F35_RS29480	COG1177	transmembrane transport
E4F35_RS29490	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4F35_RS29495	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4F35_RS29540	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E4F35_RS29540	COG1796	DNA polymerase
E4F35_RS29575	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F35_RS29585	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4F35_RS29635	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E4F35_RS29645	COG1335	isochorismatase
E4F35_RS29650	COG0583	DNA-binding transcription factor activity
E4F35_RS29660	COG2814	Major facilitator Superfamily
E4F35_RS29700	COG1741	Belongs to the pirin family
E4F35_RS29705	COG0583	DNA-binding transcription factor activity
E4F35_RS29755	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4F35_RS29805	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4F35_RS30005	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4F35_RS30040	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4F35_RS30090	COG3193	protein, possibly involved in utilization of glycolate and propanediol
E4F35_RS30100	COG0672	)-iron permease
E4F35_RS30105	COG4633	Protein conserved in bacteria
E4F35_RS30115	COG0556	nucleotide-excision repair
E4F35_RS30130	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS30135	COG0667	Aldo Keto reductase
E4F35_RS30140	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4F35_RS30155	COG0789	Transcriptional regulator
E4F35_RS30210	COG1012	belongs to the aldehyde dehydrogenase family
E4F35_RS30225	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F35_RS30250	COG2271	Major facilitator Superfamily
E4F35_RS30255	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4F35_RS30260	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E4F35_RS30305	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4F35_RS30320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4F35_RS30330	COG0531	amino acid
E4F35_RS30340	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E4F35_RS30365	COG2259	Doxx family
E4F35_RS30375	COG1620	l-lactate permease
E4F35_RS30380	COG1556	Lactate utilization protein
E4F35_RS30385	COG1139	Iron-sulfur cluster binding protein
E4F35_RS30390	COG0247	lactate metabolic process
E4F35_RS30395	COG2186	Transcriptional regulator
E4F35_RS30425	COG2011	ABC-type metal ion transport system permease component
E4F35_RS30430	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4F35_RS30450	COG2197	response regulator
E4F35_RS30500	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4F35_RS30510	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F35_RS30510	COG3321	synthase
E4F35_RS30510	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS30510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4F35_RS30510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4F35_RS30515	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E4F35_RS30525	COG0019	diaminopimelate decarboxylase activity
E4F35_RS30530	COG0318	PFAM AMP-dependent synthetase and ligase
E4F35_RS30575	COG1301	dicarboxylic acid transport
E4F35_RS30590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4F35_RS30595	COG0657	acetylesterase activity
E4F35_RS30600	COG0583	DNA-binding transcription factor activity
E4F35_RS30635	COG1942	4-Oxalocrotonate Tautomerase
E4F35_RS30640	COG0583	DNA-binding transcription factor activity
E4F35_RS30645	COG0709	Synthesizes selenophosphate from selenide and ATP
E4F35_RS30680	COG1414	Transcriptional regulator
E4F35_RS30685	COG1288	antiporter activity
E4F35_RS30695	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4F35_RS30735	COG0840	transmembrane signaling receptor activity
E4F35_RS30750	COG0183	Belongs to the thiolase family
E4F35_RS30760	COG1414	Transcriptional regulator
E4F35_RS30765	COG1309	transcriptional regulator
E4F35_RS30785	COG1473	amidohydrolase
E4F35_RS30790	COG0583	DNA-binding transcription factor activity
E4F35_RS30805	COG2755	lipolytic protein G-D-S-L family
E4F35_RS30805	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4F35_RS30835	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS30870	COG2376	Dihydroxyacetone kinase
E4F35_RS30875	COG1063	alcohol dehydrogenase
E4F35_RS30880	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS30885	COG1879	ABC-type sugar transport system periplasmic component
E4F35_RS30890	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F35_RS30895	COG1129	ABC transporter
E4F35_RS30900	COG0698	ribose 5-phosphate isomerase
E4F35_RS30910	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS30925	COG1840	ABC-type Fe3 transport system, periplasmic component
E4F35_RS30930	COG3842	ATPase activity
E4F35_RS30960	COG3720	iron ion transport
E4F35_RS30965	COG4558	Periplasmic binding protein
E4F35_RS30975	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4F35_RS30980	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E4F35_RS30985	COG2860	membrane
E4F35_RS31005	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E4F35_RS31015	COG1271	oxidase subunit
E4F35_RS31020	COG1294	oxidase, subunit
E4F35_RS31045	COG1562	ergosterol biosynthetic process
E4F35_RS31055	COG0346	lactoylglutathione lyase activity
E4F35_RS31145	COG1285	pathogenesis
E4F35_RS31170	COG0840	transmembrane signaling receptor activity
E4F35_RS31180	COG0535	radical SAM domain protein
E4F35_RS31245	COG0840	transmembrane signaling receptor activity
E4F35_RS31305	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E4F35_RS31310	COG0511	ligase activity, forming carbon-carbon bonds
E4F35_RS31325	COG1984	allophanate hydrolase subunit 2
E4F35_RS31380	COG0583	DNA-binding transcription factor activity
E4F35_RS31495	COG2885	chlorophyll binding
E4F35_RS31535	COG0367	asparagine synthase
E4F35_RS31565	COG3537	Alpha-1,2-mannosidase
E4F35_RS31595	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS31655	COG0583	DNA-binding transcription factor activity
E4F35_RS31660	COG1473	amidohydrolase
E4F35_RS31675	COG0513	Belongs to the DEAD box helicase family
E4F35_RS31710	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F35_RS31715	COG1879	ABC-type sugar transport system periplasmic component
E4F35_RS31765	COG5001	Diguanylate cyclase
E4F35_RS31765	COG2203	Gaf domain
E4F35_RS31765	COG4251	negative regulation of phosphorylation
E4F35_RS31765	COG3706	GGDEF domain
E4F35_RS31800	COG3321	synthase
E4F35_RS31800	COG0300	oxidoreductase activity
E4F35_RS31800	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS31800	COG0318	PFAM AMP-dependent synthetase and ligase
E4F35_RS31800	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F35_RS31815	COG3835	regulator
E4F35_RS31820	COG0469	pyruvate kinase activity
E4F35_RS31825	COG1929	Belongs to the glycerate kinase type-1 family
E4F35_RS31830	COG2271	Major facilitator Superfamily
E4F35_RS31850	COG3547	Transposase (IS116 IS110 IS902 family)
E4F35_RS31875	COG3188	usher protein
E4F35_RS32015	COG2885	chlorophyll binding
E4F35_RS32030	COG3188	usher protein
E4F35_RS32035	COG3121	Chaperone
E4F35_RS32060	COG5295	Hep Hag repeat protein
E4F35_RS32090	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4F35_RS32130	COG0432	Pfam Uncharacterised protein family UPF0047
E4F35_RS32175	COG1177	transmembrane transport
E4F35_RS32180	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F35_RS32275	COG0477	Major facilitator Superfamily
E4F35_RS32290	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4F35_RS32325	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4F35_RS32330	COG1595	DNA-templated transcription, initiation
E4F35_RS32410	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4F35_RS32415	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4F35_RS32420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4F35_RS32425	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4F35_RS32445	COG0302	gtp cyclohydrolase
E4F35_RS32450	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS32460	COG1045	serine acetyltransferase
E4F35_RS32505	COG0589	response to stress
E4F35_RS32510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4F35_RS32515	COG0583	DNA-binding transcription factor activity
E4F35_RS32590	COG0671	phosphoesterase, PA-phosphatase related
E4F35_RS32600	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS32625	COG0625	glutathione transferase activity
E4F35_RS32645	COG0583	DNA-binding transcription factor activity
E4F35_RS32650	COG0473	3-isopropylmalate dehydrogenase activity
E4F35_RS32675	COG1309	transcriptional regulator
E4F35_RS32700	COG1396	sequence-specific DNA binding
E4F35_RS32740	COG1192	Involved in chromosome partitioning
E4F35_RS32750	COG1393	Belongs to the ArsC family
E4F35_RS32760	COG1595	DNA-templated transcription, initiation
E4F35_RS32810	COG1562	ergosterol biosynthetic process
E4F35_RS32820	COG1657	PFAM Prenyltransferase squalene oxidase
E4F35_RS32835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F35_RS32840	COG0765	amino acid transport
E4F35_RS32845	COG1126	abc transporter atp-binding protein
E4F35_RS32855	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4F35_RS32885	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS32895	COG2072	flavoprotein involved in K transport
E4F35_RS32900	COG1136	(ABC) transporter
E4F35_RS32945	COG5002	protein histidine kinase activity
E4F35_RS32945	COG3447	MASE1 domain protein
E4F35_RS32945	COG5001	Diguanylate cyclase
E4F35_RS33010	COG0454	-acetyltransferase
E4F35_RS33010	COG0456	acetyltransferase
E4F35_RS33040	COG0154	amidase activity
E4F35_RS33050	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS33110	COG3302	dmso reductase anchor subunit
E4F35_RS33115	COG0437	4 iron, 4 sulfur cluster binding
E4F35_RS33120	COG0243	molybdopterin cofactor binding
E4F35_RS33145	COG3246	L-lysine catabolic process to acetate
E4F35_RS33150	COG2175	clavaminate synthase activity
E4F35_RS33170	COG2909	trisaccharide binding
E4F35_RS33195	COG0071	Belongs to the small heat shock protein (HSP20) family
E4F35_RS33210	COG2239	Acts as a magnesium transporter
E4F35_RS33275	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4F35_RS33335	COG0022	dehydrogenase e1 component
E4F35_RS33365	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4F35_RS33385	COG2091	lysine biosynthetic process via aminoadipic acid
E4F35_RS33395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4F35_RS33400	COG2084	Dehydrogenase
E4F35_RS33415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4F35_RS33420	COG0688	phosphatidylethanolamine metabolic process
E4F35_RS33440	COG5265	(ABC) transporter
E4F35_RS33450	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS33460	COG0859	PFAM glycosyl transferase family 9
E4F35_RS33465	COG2192	nodulation
E4F35_RS33500	COG2204	response regulator
E4F35_RS33515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F35_RS33515	COG0784	Response regulator, receiver
E4F35_RS33515	COG2198	Histidine kinase
E4F35_RS33515	COG2205	protein histidine kinase activity
E4F35_RS33530	COG2823	Periplasmic or secreted lipoprotein
E4F35_RS33535	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS33560	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS33580	COG1914	H( )-stimulated, divalent metal cation uptake system
E4F35_RS33585	COG1573	uracil-dna glycosylase
E4F35_RS33605	COG0517	IMP dehydrogenase activity
E4F35_RS33605	COG0516	GMP reductase activity
E4F35_RS33695	COG3685	Protein conserved in bacteria
E4F35_RS33700	COG3546	catalase activity
E4F35_RS33710	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4F35_RS33785	COG2271	Major facilitator Superfamily
E4F35_RS33805	COG1113	amino acid transport
E4F35_RS33810	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F35_RS33825	COG1522	sequence-specific DNA binding
E4F35_RS33870	COG4964	Belongs to the GSP D family
E4F35_RS33920	COG0463	Glycosyl transferase, family 2
E4F35_RS33975	COG1966	Carbon starvation protein
E4F35_RS33980	COG2879	small protein
E4F35_RS34000	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4F35_RS34020	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4F35_RS34050	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4F35_RS34100	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4F35_RS34115	COG2801	Transposase and inactivated derivatives
E4F35_RS34150	COG3104	oligopeptide transport
E4F35_RS34175	COG0601	transmembrane transport
E4F35_RS34180	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4F35_RS34230	COG2610	gluconate transmembrane transporter activity
E4F35_RS34255	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4F35_RS34300	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4F35_RS34310	COG0583	DNA-binding transcription factor activity
E4F35_RS34320	COG0477	Major facilitator Superfamily
E4F35_RS34340	COG1104	cysteine desulfurase activity
E4F35_RS34345	COG0477	Major facilitator Superfamily
E4F35_RS34375	COG0583	DNA-binding transcription factor activity
E4F35_RS34380	COG3048	D-serine ammonia-lyase activity
E4F35_RS34395	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS34550	COG1609	Transcriptional regulator
E4F35_RS34570	COG3842	ATPase activity
E4F35_RS34575	COG1653	transport
E4F35_RS34580	COG1175	transmembrane transport
E4F35_RS34585	COG0395	ABC-type sugar transport system, permease component
E4F35_RS34610	COG3436	PFAM IS66 Orf2 family protein
E4F35_RS34620	COG0251	oxidation-reduction process
E4F35_RS34625	COG1301	dicarboxylic acid transport
E4F35_RS34655	COG3209	COG3209 Rhs family protein
E4F35_RS34715	COG0402	S-adenosylhomocysteine deaminase activity
E4F35_RS34735	COG0494	nUDIX hydrolase
E4F35_RS34800	COG1022	Amp-dependent synthetase and ligase
E4F35_RS34810	COG3246	L-lysine catabolic process to acetate
E4F35_RS34825	COG1960	acyl-CoA dehydrogenase activity
E4F35_RS34830	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4F35_RS34835	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS34845	COG1960	acyl-CoA dehydrogenase activity
E4F35_RS34865	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4F35_RS34920	COG1253	flavin adenine dinucleotide binding
E4F35_RS34925	COG0583	DNA-binding transcription factor activity
E4F35_RS34960	COG1215	transferase activity, transferring glycosyl groups
E4F35_RS35065	COG0504	CTP synthase activity
E4F35_RS35080	COG0672	)-iron permease
E4F35_RS35150	COG1404	Belongs to the peptidase S8 family
E4F35_RS35160	COG2936	dipeptidyl-peptidase activity
E4F35_RS35165	COG1573	uracil-dna glycosylase
E4F35_RS35320	COG0596	Alpha beta hydrolase
E4F35_RS35355	COG0625	glutathione transferase activity
E4F35_RS35370	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4F35_RS35375	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4F35_RS35410	COG0295	cytidine deaminase activity
E4F35_RS35420	COG2823	Periplasmic or secreted lipoprotein
E4F35_RS35445	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4F35_RS35450	COG0280	phosphate acetyltransferase
E4F35_RS35455	COG3243	poly(R)-hydroxyalkanoic acid synthase
E4F35_RS35470	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E4F35_RS35485	COG0356	it plays a direct role in the translocation of protons across the membrane
E4F35_RS35495	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4F35_RS35495	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E4F35_RS35500	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E4F35_RS35505	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E4F35_RS35525	COG0840	transmembrane signaling receptor activity
E4F35_RS35535	COG4191	Histidine kinase
E4F35_RS35535	COG0784	Response regulator, receiver
E4F35_RS35540	COG0842	Transport permease protein
E4F35_RS35545	COG1129	ABC transporter
E4F35_RS35545	COG0842	Transport permease protein
E4F35_RS35550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4F35_RS35560	COG1309	transcriptional regulator
E4F35_RS35570	COG0589	response to stress
E4F35_RS35585	COG1136	(ABC) transporter
E4F35_RS35610	COG0840	transmembrane signaling receptor activity
E4F35_RS35650	COG1611	Belongs to the LOG family
E4F35_RS35685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4F35_RS35695	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS35705	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4F35_RS35745	COG0833	amino acid
E4F35_RS35780	COG1335	isochorismatase
E4F35_RS35800	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS35805	COG0633	Ferredoxin
E4F35_RS35805	COG0543	2 iron, 2 sulfur cluster binding
E4F35_RS35810	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E4F35_RS35815	COG4638	Rieske (2fe-2S)
E4F35_RS35820	COG0583	DNA-binding transcription factor activity
E4F35_RS35840	COG1902	pentaerythritol trinitrate reductase activity
E4F35_RS35840	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4F35_RS35860	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4F35_RS35890	COG4638	Rieske (2fe-2S)
E4F35_RS35895	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E4F35_RS35900	COG2146	nitrite reductase [NAD(P)H] activity
E4F35_RS35915	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4F35_RS35930	COG2733	membrane
E4F35_RS35935	COG0025	NhaP-type Na H and K H
E4F35_RS35945	COG1012	belongs to the aldehyde dehydrogenase family
E4F35_RS35960	COG0642	Histidine kinase
E4F35_RS35965	COG0840	transmembrane signaling receptor activity
E4F35_RS36005	COG0038	chloride channel
E4F35_RS36040	COG4977	sequence-specific DNA binding
E4F35_RS36050	COG5265	(ABC) transporter
E4F35_RS36060	COG2837	iron assimilation
E4F35_RS36095	COG0583	DNA-binding transcription factor activity
E4F35_RS36120	COG1028	Short-chain dehydrogenase reductase Sdr
E4F35_RS36145	COG2130	NADP-dependent
E4F35_RS36180	COG0628	permease
E4F35_RS36215	COG3795	YCII-related domain
E4F35_RS36220	COG3795	YCII-related domain
E4F35_RS36230	COG4941	Belongs to the sigma-70 factor family
E4F35_RS36245	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4F35_RS36255	COG1592	Rubrerythrin
E4F35_RS36290	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4F35_RS36310	COG0489	protein tyrosine kinase activity
E4F35_RS36310	COG3206	protein involved in exopolysaccharide biosynthesis
E4F35_RS36330	COG0438	transferase activity, transferring glycosyl groups
E4F35_RS36335	COG0438	transferase activity, transferring glycosyl groups
E4F35_RS36360	COG5642	Protein of unknown function (DUF2384)
E4F35_RS36365	COG5654	RES domain protein
E4F35_RS36370	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4F35_RS36410	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F35_RS36430	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4F35_RS36445	COG4569	acetaldehyde dehydrogenase (acetylating) activity
E4F35_RS36515	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4F35_RS36520	COG0352	thiamine-phosphate diphosphorylase activity
E4F35_RS36525	COG1253	flavin adenine dinucleotide binding
E4F35_RS36540	COG0583	DNA-binding transcription factor activity
E4F35_RS36575	COG4149	molybdate abc transporter
E4F35_RS36580	COG0725	ABC transporter, periplasmic molybdate-binding protein
E4F35_RS36605	COG1764	response to oxidative stress
E4F35_RS36610	COG1846	Transcriptional regulator
E4F35_RS36635	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4F35_RS36645	COG4695	Portal protein
E4F35_RS36685	COG1683	Conserved Protein
E4F35_RS36700	COG1611	Belongs to the LOG family
E4F35_RS36710	COG1252	NADH dehydrogenase
E4F35_RS36730	COG0412	Dienelactone hydrolase
E4F35_RS36750	COG0142	geranyltranstransferase activity
E4F35_RS36775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4F35_RS36800	COG2081	HI0933 family