locus-tag	class	description
E4F37_RS00015	COG0583	DNA-binding transcription factor activity
E4F37_RS00020	COG0625	glutathione transferase activity
E4F37_RS00040	COG1846	Transcriptional regulator
E4F37_RS00045	COG2807	transmembrane transport
E4F37_RS00050	COG1649	PFAM Uncharacterised BCR, COG1649
E4F37_RS00070	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E4F37_RS00080	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4F37_RS00100	COG3979	chitinase
E4F37_RS00120	COG0400	carboxylic ester hydrolase activity
E4F37_RS00125	COG4644	lycopene metabolic process
E4F37_RS00140	COG4974	Belongs to the 'phage' integrase family
E4F37_RS00175	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
E4F37_RS00205	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4F37_RS00210	COG4774	siderophore transport
E4F37_RS00215	COG3486	L-lysine 6-monooxygenase (NADPH) activity
E4F37_RS00265	COG1120	ATPase activity
E4F37_RS00300	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS00305	COG1070	Carbohydrate kinase
E4F37_RS00310	COG1063	alcohol dehydrogenase
E4F37_RS00320	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F37_RS00325	COG1129	ABC transporter
E4F37_RS00330	COG1879	ABC-type sugar transport system periplasmic component
E4F37_RS00365	COG2375	cellular response to nickel ion
E4F37_RS00365	COG1132	(ABC) transporter
E4F37_RS00375	COG3121	Chaperone
E4F37_RS00385	COG3539	Fimbrial protein
E4F37_RS00415	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F37_RS00425	COG1309	transcriptional regulator
E4F37_RS00435	COG0739	heme binding
E4F37_RS00440	COG0765	amino acid transport
E4F37_RS00445	COG4597	amino acid ABC transporter
E4F37_RS00460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F37_RS00505	COG4964	Belongs to the GSP D family
E4F37_RS00530	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4F37_RS00535	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E4F37_RS00550	COG0477	Major facilitator Superfamily
E4F37_RS00560	COG2719	SpoVR family
E4F37_RS00565	COG2718	Belongs to the UPF0229 family
E4F37_RS00570	COG2766	serine protein kinase
E4F37_RS00580	COG0840	transmembrane signaling receptor activity
E4F37_RS00585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4F37_RS00590	COG1609	Transcriptional regulator
E4F37_RS00595	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F37_RS00600	COG1129	ABC transporter
E4F37_RS00605	COG1879	ABC-type sugar transport system periplasmic component
E4F37_RS00610	COG0583	DNA-binding transcription factor activity
E4F37_RS00615	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4F37_RS00620	COG4208	sulfate ABC transporter
E4F37_RS00625	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4F37_RS00630	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4F37_RS00680	COG0701	Predicted permease
E4F37_RS00685	COG0667	Aldo Keto reductase
E4F37_RS00715	COG1301	dicarboxylic acid transport
E4F37_RS00760	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4F37_RS00825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F37_RS00830	COG0765	amino acid transport
E4F37_RS00835	COG0673	inositol 2-dehydrogenase activity
E4F37_RS00840	COG1802	Transcriptional regulator
E4F37_RS00850	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4F37_RS00860	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4F37_RS00865	COG0557	exoribonuclease II activity
E4F37_RS00880	COG0840	transmembrane signaling receptor activity
E4F37_RS00910	COG0519	Catalyzes the synthesis of GMP from XMP
E4F37_RS00915	COG2814	Major facilitator Superfamily
E4F37_RS00925	COG0318	PFAM AMP-dependent synthetase and ligase
E4F37_RS00995	COG4964	Belongs to the GSP D family
E4F37_RS01055	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4F37_RS01060	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4F37_RS01065	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4F37_RS01070	COG0567	Dehydrogenase, E1 component
E4F37_RS01075	COG1217	gtp-binding protein TYPA
E4F37_RS01085	COG1846	Transcriptional regulator
E4F37_RS01095	COG1566	PFAM secretion protein HlyD family protein
E4F37_RS01100	COG2814	Major facilitator Superfamily
E4F37_RS01110	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4F37_RS01125	COG2251	uridine kinase activity
E4F37_RS01125	COG0195	Participates in both transcription termination and antitermination
E4F37_RS01135	COG1187	pseudouridine synthase activity
E4F37_RS01140	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4F37_RS01145	COG0583	DNA-binding transcription factor activity
E4F37_RS01205	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E4F37_RS01230	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4F37_RS01230	COG2755	lipolytic protein G-D-S-L family
E4F37_RS01245	COG0776	regulation of translation
E4F37_RS01270	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E4F37_RS01285	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4F37_RS01290	COG0251	oxidation-reduction process
E4F37_RS01295	COG2267	carboxylic ester hydrolase activity
E4F37_RS01305	COG0583	DNA-binding transcription factor activity
E4F37_RS01320	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS01375	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS01410	COG0477	Major facilitator Superfamily
E4F37_RS01435	COG1295	ribonuclease BN
E4F37_RS01450	COG0277	FAD linked oxidase domain protein
E4F37_RS01465	COG0583	DNA-binding transcription factor activity
E4F37_RS01500	COG0840	transmembrane signaling receptor activity
E4F37_RS01505	COG2223	nitrite transmembrane transporter activity
E4F37_RS01510	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4F37_RS01515	COG0210	DNA helicase
E4F37_RS01520	COG0525	valine-tRNA ligase activity
E4F37_RS01525	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4F37_RS01535	COG5002	protein histidine kinase activity
E4F37_RS01545	COG0745	RESPONSE REGULATOR receiver
E4F37_RS01555	COG0425	Belongs to the sulfur carrier protein TusA family
E4F37_RS01565	COG0673	inositol 2-dehydrogenase activity
E4F37_RS01570	COG0673	inositol 2-dehydrogenase activity
E4F37_RS01585	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F37_RS01600	COG3962	Belongs to the TPP enzyme family
E4F37_RS01610	COG3718	enzyme involved in inositol metabolism
E4F37_RS01620	COG0411	ABC transporter
E4F37_RS01630	COG0824	Thioesterase
E4F37_RS01655	COG2816	NAD+ diphosphatase activity
E4F37_RS01670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4F37_RS01680	COG0477	Major facilitator Superfamily
E4F37_RS01705	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4F37_RS01715	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4F37_RS01725	COG0494	nUDIX hydrolase
E4F37_RS01750	COG1858	cytochrome C peroxidase
E4F37_RS01755	COG3511	phospholipase C
E4F37_RS01770	COG1566	PFAM secretion protein HlyD family protein
E4F37_RS01780	COG2814	Major facilitator Superfamily
E4F37_RS01785	COG1538	Outer membrane efflux protein
E4F37_RS01795	COG2197	response regulator
E4F37_RS01850	COG0583	DNA-binding transcription factor activity
E4F37_RS01860	COG2814	Major facilitator Superfamily
E4F37_RS01900	COG1914	H( )-stimulated, divalent metal cation uptake system
E4F37_RS02050	COG0457	Tetratricopeptide repeat
E4F37_RS02050	COG0859	PFAM glycosyl transferase family 9
E4F37_RS02100	COG0583	DNA-binding transcription factor activity
E4F37_RS02150	COG0366	Alpha amylase catalytic
E4F37_RS02155	COG0366	Alpha amylase catalytic
E4F37_RS02205	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E4F37_RS02270	COG4942	peptidase
E4F37_RS02275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4F37_RS02290	COG0534	Mate efflux family protein
E4F37_RS02370	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4F37_RS02385	COG0745	RESPONSE REGULATOR receiver
E4F37_RS02400	COG0581	inorganic phosphate transmembrane transporter activity
E4F37_RS02405	COG0573	inorganic phosphate transmembrane transporter activity
E4F37_RS02410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4F37_RS02425	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4F37_RS02430	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4F37_RS02440	COG1534	Rna-binding protein
E4F37_RS02450	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4F37_RS02455	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4F37_RS02465	COG0505	Belongs to the CarA family
E4F37_RS02495	COG0741	lytic transglycosylase activity
E4F37_RS02495	COG1388	LysM domain
E4F37_RS02500	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4F37_RS02505	COG2226	methyltransferase
E4F37_RS02510	COG0328	RNA-DNA hybrid ribonuclease activity
E4F37_RS02515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4F37_RS02535	COG0477	Major facilitator Superfamily
E4F37_RS02575	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4F37_RS02585	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
E4F37_RS02605	COG3052	prosthetic group binding
E4F37_RS02630	COG0583	DNA-binding transcription factor activity
E4F37_RS02640	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4F37_RS02645	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E4F37_RS02690	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F37_RS02725	COG0583	DNA-binding transcription factor activity
E4F37_RS02755	COG1522	sequence-specific DNA binding
E4F37_RS02830	COG1609	Transcriptional regulator
E4F37_RS02835	COG1840	ABC-type Fe3 transport system, periplasmic component
E4F37_RS02840	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4F37_RS02855	COG1177	transmembrane transport
E4F37_RS02865	COG3842	ATPase activity
E4F37_RS02875	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E4F37_RS02905	COG2814	Major facilitator Superfamily
E4F37_RS02915	COG0697	spore germination
E4F37_RS02930	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E4F37_RS02935	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
E4F37_RS02985	COG2200	EAL domain
E4F37_RS02995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4F37_RS03000	COG1074	ATP-dependent DNA helicase activity
E4F37_RS03005	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4F37_RS03015	COG1289	transmembrane transporter activity
E4F37_RS03040	COG1840	ABC-type Fe3 transport system, periplasmic component
E4F37_RS03045	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F37_RS03050	COG3842	ATPase activity
E4F37_RS03055	COG1522	sequence-specific DNA binding
E4F37_RS03075	COG1959	2 iron, 2 sulfur cluster binding
E4F37_RS03110	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F37_RS03115	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F37_RS03155	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4F37_RS03170	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4F37_RS03170	COG2010	Cytochrome c
E4F37_RS03175	COG2863	cytochrome
E4F37_RS03210	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4F37_RS03230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4F37_RS03245	COG0006	proline dipeptidase activity
E4F37_RS03320	COG2866	Carboxypeptidase
E4F37_RS03335	COG0436	Aminotransferase
E4F37_RS03345	COG1024	Enoyl-CoA hydratase
E4F37_RS03350	COG0588	phosphoglycerate mutase activity
E4F37_RS03360	COG1960	acyl-CoA dehydrogenase activity
E4F37_RS03380	COG2030	dehydratase
E4F37_RS03380	COG1012	belongs to the aldehyde dehydrogenase family
E4F37_RS03385	COG1960	acyl-CoA dehydrogenase activity
E4F37_RS03390	COG1960	acyl-CoA dehydrogenase activity
E4F37_RS03410	COG1007	ATP synthesis coupled electron transport
E4F37_RS03445	COG1034	ATP synthesis coupled electron transport
E4F37_RS03455	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E4F37_RS03490	COG0149	triose-phosphate isomerase activity
E4F37_RS03495	COG0604	alcohol dehydrogenase
E4F37_RS03495	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F37_RS03495	COG3321	synthase
E4F37_RS03495	COG4221	oxidoreductase activity
E4F37_RS03515	COG0683	leucine binding
E4F37_RS03530	COG0288	reversible hydration of carbon dioxide
E4F37_RS03535	COG0659	secondary active sulfate transmembrane transporter activity
E4F37_RS03545	COG1183	phosphatidylcholine synthase activity
E4F37_RS03565	COG0028	Belongs to the TPP enzyme family
E4F37_RS03600	COG0438	transferase activity, transferring glycosyl groups
E4F37_RS03620	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS03630	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4F37_RS03640	COG0154	amidase activity
E4F37_RS03650	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4F37_RS03685	COG0745	RESPONSE REGULATOR receiver
E4F37_RS03690	COG2205	protein histidine kinase activity
E4F37_RS03705	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E4F37_RS03710	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E4F37_RS03745	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS03765	COG0151	Belongs to the GarS family
E4F37_RS03780	COG0799	negative regulation of ribosome biogenesis
E4F37_RS03805	COG2233	PERMEase
E4F37_RS03860	COG1595	DNA-templated transcription, initiation
E4F37_RS03870	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4F37_RS03910	COG0859	PFAM glycosyl transferase family 9
E4F37_RS03915	COG0438	transferase activity, transferring glycosyl groups
E4F37_RS03955	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4F37_RS03965	COG0513	Belongs to the DEAD box helicase family
E4F37_RS04000	COG1674	ftsk spoiiie
E4F37_RS04005	COG2706	6-phosphogluconolactonase activity
E4F37_RS04015	COG3387	PFAM Glycoside hydrolase 15-related
E4F37_RS04025	COG1309	transcriptional regulator
E4F37_RS04030	COG2878	Part of a membrane complex involved in electron transport
E4F37_RS04035	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4F37_RS04075	COG3135	benzoate transporter
E4F37_RS04090	COG2764	glyoxalase bleomycin resistance protein dioxygenase
E4F37_RS04105	COG4106	trans-aconitate 2-methyltransferase activity
E4F37_RS04130	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F37_RS04140	COG0697	spore germination
E4F37_RS04145	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F37_RS04190	COG0477	Major facilitator Superfamily
E4F37_RS04200	COG0583	DNA-binding transcription factor activity
E4F37_RS04215	COG0583	DNA-binding transcription factor activity
E4F37_RS04245	COG0488	(ABC) transporter
E4F37_RS04255	COG1773	rubredoxin
E4F37_RS04435	COG1881	PFAM PEBP family protein
E4F37_RS04440	COG2814	Major facilitator Superfamily
E4F37_RS04460	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E4F37_RS04490	COG1116	anion transmembrane transporter activity
E4F37_RS04495	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F37_RS04530	COG1741	Belongs to the pirin family
E4F37_RS04545	COG4215	(ABC) transporter
E4F37_RS04565	COG0347	Belongs to the P(II) protein family
E4F37_RS04585	COG1472	Belongs to the glycosyl hydrolase 3 family
E4F37_RS04595	COG2827	Endonuclease containing a URI domain
E4F37_RS04600	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4F37_RS04615	COG2271	Major facilitator Superfamily
E4F37_RS04650	COG2226	methyltransferase
E4F37_RS04690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4F37_RS04715	COG0489	protein tyrosine kinase activity
E4F37_RS04725	COG2885	chlorophyll binding
E4F37_RS04725	COG3047	cAMP biosynthetic process
E4F37_RS04755	COG2911	Protein conserved in bacteria
E4F37_RS04760	COG0729	surface antigen
E4F37_RS04770	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4F37_RS04790	COG0489	protein tyrosine kinase activity
E4F37_RS04795	COG2259	Doxx family
E4F37_RS04800	COG1492	cobalamin metabolic process
E4F37_RS04815	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E4F37_RS04825	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4F37_RS04845	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E4F37_RS04850	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E4F37_RS04855	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E4F37_RS04865	COG4206	TonB-dependent receptor
E4F37_RS04900	COG0583	DNA-binding transcription factor activity
E4F37_RS04915	COG4654	Cytochrome c, class I
E4F37_RS04935	COG0795	lipopolysaccharide-transporting ATPase activity
E4F37_RS04950	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4F37_RS04950	COG1648	precorrin-2 dehydrogenase activity
E4F37_RS04955	COG2895	sulfate adenylyltransferase (ATP) activity
E4F37_RS04965	COG0175	sulfate reduction
E4F37_RS04980	COG0583	DNA-binding transcription factor activity
E4F37_RS04995	COG1396	sequence-specific DNA binding
E4F37_RS05005	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4F37_RS05010	COG2258	MOSC domain
E4F37_RS05015	COG2267	carboxylic ester hydrolase activity
E4F37_RS05025	COG0583	DNA-binding transcription factor activity
E4F37_RS05035	COG1187	pseudouridine synthase activity
E4F37_RS05050	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4F37_RS05050	COG0543	2 iron, 2 sulfur cluster binding
E4F37_RS05055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4F37_RS05060	COG0456	acetyltransferase
E4F37_RS05100	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4F37_RS05105	COG1047	Peptidyl-prolyl cis-trans
E4F37_RS05125	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4F37_RS05150	COG1511	domain protein
E4F37_RS05150	COG3264	Mechanosensitive ion channel
E4F37_RS05155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4F37_RS05155	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4F37_RS05160	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4F37_RS05165	COG0196	riboflavin kinase activity
E4F37_RS05170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4F37_RS05200	COG1113	amino acid transport
E4F37_RS05205	COG0542	response to heat
E4F37_RS05260	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4F37_RS05295	COG0656	L-ascorbic acid biosynthetic process
E4F37_RS05300	COG2188	Transcriptional regulator
E4F37_RS05320	COG2814	Major facilitator Superfamily
E4F37_RS05390	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4F37_RS05395	COG1570	exodeoxyribonuclease VII activity
E4F37_RS05405	COG1663	tetraacyldisaccharide 4'-kinase activity
E4F37_RS05445	COG0728	peptidoglycan biosynthetic process
E4F37_RS05465	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4F37_RS05485	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4F37_RS05490	COG0318	PFAM AMP-dependent synthetase and ligase
E4F37_RS05495	COG4974	Belongs to the 'phage' integrase family
E4F37_RS05505	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4F37_RS05510	COG0802	atpase or kinase
E4F37_RS05515	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4F37_RS05530	COG1741	Belongs to the pirin family
E4F37_RS05535	COG3118	belongs to the thioredoxin family
E4F37_RS05545	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4F37_RS05555	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4F37_RS05565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4F37_RS05575	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4F37_RS05580	COG1522	sequence-specific DNA binding
E4F37_RS05600	COG2271	Major facilitator Superfamily
E4F37_RS05610	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4F37_RS05615	COG1012	belongs to the aldehyde dehydrogenase family
E4F37_RS05625	COG0583	DNA-binding transcription factor activity
E4F37_RS05630	COG0246	Mannitol dehydrogenase
E4F37_RS05635	COG1070	Carbohydrate kinase
E4F37_RS05640	COG2390	Transcriptional regulator
E4F37_RS05655	COG0583	DNA-binding transcription factor activity
E4F37_RS05670	COG3842	ATPase activity
E4F37_RS05675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4F37_RS05685	COG1175	transmembrane transport
E4F37_RS05700	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4F37_RS05710	COG0735	belongs to the Fur family
E4F37_RS05720	COG1121	(ABC) transporter
E4F37_RS05725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4F37_RS05730	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4F37_RS05745	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4F37_RS05750	COG2233	PERMEase
E4F37_RS05765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F37_RS05770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4F37_RS05800	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4F37_RS05845	COG0009	L-threonylcarbamoyladenylate synthase
E4F37_RS05850	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4F37_RS05855	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4F37_RS05860	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4F37_RS05870	COG0469	pyruvate kinase activity
E4F37_RS05880	COG0126	phosphoglycerate kinase activity
E4F37_RS05905	COG0859	PFAM glycosyl transferase family 9
E4F37_RS05915	COG0429	hydrolase of the alpha beta-hydrolase fold
E4F37_RS05925	COG4783	chaperone-mediated protein folding
E4F37_RS05960	COG3307	-O-antigen
E4F37_RS05965	COG4969	Belongs to the N-Me-Phe pilin family
E4F37_RS05970	COG0861	Integral membrane protein TerC family
E4F37_RS05975	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4F37_RS05990	COG2137	regulation of response to DNA damage stimulus
E4F37_RS05995	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4F37_RS06025	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4F37_RS06055	COG0583	DNA-binding transcription factor activity
E4F37_RS06110	COG5002	protein histidine kinase activity
E4F37_RS06110	COG0784	Response regulator, receiver
E4F37_RS06115	COG0583	DNA-binding transcription factor activity
E4F37_RS06155	COG0028	Belongs to the TPP enzyme family
E4F37_RS06160	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4F37_RS06165	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4F37_RS06250	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E4F37_RS06255	COG0583	DNA-binding transcription factor activity
E4F37_RS06260	COG1301	dicarboxylic acid transport
E4F37_RS06275	COG0840	transmembrane signaling receptor activity
E4F37_RS06325	COG4948	Mandelate Racemase Muconate Lactonizing
E4F37_RS06355	COG0513	Belongs to the DEAD box helicase family
E4F37_RS06400	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4F37_RS06405	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4F37_RS06420	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4F37_RS06425	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4F37_RS06430	COG0367	asparagine synthase
E4F37_RS06445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4F37_RS06455	COG1396	sequence-specific DNA binding
E4F37_RS06460	COG2814	Major facilitator Superfamily
E4F37_RS06465	COG0583	DNA-binding transcription factor activity
E4F37_RS06480	COG1702	phosphate starvation-inducible protein PhoH
E4F37_RS06495	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
E4F37_RS06505	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4F37_RS06510	COG0752	glycyl-tRNA synthetase alpha subunit
E4F37_RS06515	COG0751	glycine-tRNA ligase activity
E4F37_RS06520	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4F37_RS06525	COG0204	Acyl-transferase
E4F37_RS06555	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
E4F37_RS06570	COG3178	'Phosphotransferase
E4F37_RS06575	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4F37_RS06585	COG5265	(ABC) transporter
E4F37_RS06605	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4F37_RS06610	COG1024	Enoyl-CoA hydratase
E4F37_RS06615	COG0183	Belongs to the thiolase family
E4F37_RS06620	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4F37_RS06620	COG1024	Enoyl-CoA hydratase
E4F37_RS06625	COG1960	acyl-CoA dehydrogenase activity
E4F37_RS06640	COG0494	nUDIX hydrolase
E4F37_RS06715	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4F37_RS06725	COG0251	oxidation-reduction process
E4F37_RS06730	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E4F37_RS06755	COG0477	Major facilitator Superfamily
E4F37_RS06800	COG1596	polysaccharide export
E4F37_RS06805	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4F37_RS06825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4F37_RS06835	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4F37_RS06855	COG2204	response regulator
E4F37_RS06905	COG5001	Diguanylate cyclase
E4F37_RS06905	COG5002	protein histidine kinase activity
E4F37_RS06920	COG0235	Class ii aldolase
E4F37_RS07040	COG0629	single-stranded DNA binding
E4F37_RS07045	COG2814	Major facilitator Superfamily
E4F37_RS07080	COG1280	lysine exporter protein (LysE YggA)
E4F37_RS07105	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4F37_RS07120	COG1137	ATPase activity
E4F37_RS07125	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4F37_RS07135	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4F37_RS07160	COG1194	a g-specific adenine glycosylase
E4F37_RS07175	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E4F37_RS07190	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4F37_RS07200	COG0193	aminoacyl-tRNA hydrolase activity
E4F37_RS07210	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4F37_RS07225	COG0742	ribosomal rna small subunit methyltransferase
E4F37_RS07235	COG0625	glutathione transferase activity
E4F37_RS07245	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4F37_RS07255	COG0243	molybdopterin cofactor binding
E4F37_RS07260	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4F37_RS07275	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4F37_RS07285	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4F37_RS07295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4F37_RS07310	COG1294	oxidase, subunit
E4F37_RS07340	COG1263	PTS System
E4F37_RS07340	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4F37_RS07340	COG2190	(PTS) system
E4F37_RS07345	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4F37_RS07345	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4F37_RS07350	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4F37_RS07355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4F37_RS07360	COG2188	Transcriptional regulator
E4F37_RS07370	COG0583	DNA-binding transcription factor activity
E4F37_RS07415	COG0318	PFAM AMP-dependent synthetase and ligase
E4F37_RS07425	COG1960	acyl-CoA dehydrogenase activity
E4F37_RS07435	COG2226	methyltransferase
E4F37_RS07470	COG2814	Major facilitator Superfamily
E4F37_RS07480	COG0587	DNA-directed DNA polymerase activity
E4F37_RS07495	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4F37_RS07535	COG0840	transmembrane signaling receptor activity
E4F37_RS07550	COG1999	signal sequence binding
E4F37_RS07560	COG1612	heme a metabolic process
E4F37_RS07590	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E4F37_RS07600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4F37_RS07615	COG2226	methyltransferase
E4F37_RS07620	COG1040	competence protein
E4F37_RS07635	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4F37_RS07655	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4F37_RS07665	COG0793	Belongs to the peptidase S41A family
E4F37_RS07670	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4F37_RS07680	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4F37_RS07685	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4F37_RS07695	COG0189	ligase activity
E4F37_RS07705	COG0004	ammonium transporteR
E4F37_RS07715	COG2960	long-chain fatty acid transporting porin activity
E4F37_RS07755	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4F37_RS07765	COG4191	Histidine kinase
E4F37_RS07780	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4F37_RS07790	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4F37_RS07795	COG1960	acyl-CoA dehydrogenase activity
E4F37_RS07800	COG1960	acyl-CoA dehydrogenase activity
E4F37_RS07805	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4F37_RS07805	COG1024	Enoyl-CoA hydratase
E4F37_RS07810	COG0583	DNA-binding transcription factor activity
E4F37_RS07820	COG0405	Gamma-glutamyltransferase
E4F37_RS07845	COG0583	DNA-binding transcription factor activity
E4F37_RS07850	COG2921	Belongs to the UPF0250 family
E4F37_RS07860	COG1686	Belongs to the peptidase S11 family
E4F37_RS07895	COG1127	ABC transporter
E4F37_RS07900	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4F37_RS07905	COG0737	Belongs to the 5'-nucleotidase family
E4F37_RS07920	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E4F37_RS07930	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4F37_RS07955	COG1024	Enoyl-CoA hydratase
E4F37_RS08025	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4F37_RS08030	COG4221	oxidoreductase activity
E4F37_RS08035	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS08055	COG0747	negative chemotaxis
E4F37_RS08060	COG0488	(ABC) transporter
E4F37_RS08080	COG0288	reversible hydration of carbon dioxide
E4F37_RS08085	COG0183	Belongs to the thiolase family
E4F37_RS08095	COG3012	SEC-C Motif Domain Protein
E4F37_RS08115	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4F37_RS08145	COG1785	Belongs to the alkaline phosphatase family
E4F37_RS08165	COG2199	diguanylate cyclase activity
E4F37_RS08165	COG2200	EAL domain
E4F37_RS08170	COG0025	NhaP-type Na H and K H
E4F37_RS08215	COG4650	regulator
E4F37_RS08245	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4F37_RS08265	COG1999	signal sequence binding
E4F37_RS08320	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4F37_RS08350	COG0596	Alpha beta hydrolase
E4F37_RS08365	COG0583	DNA-binding transcription factor activity
E4F37_RS08370	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS08395	COG0840	transmembrane signaling receptor activity
E4F37_RS08400	COG1609	Transcriptional regulator
E4F37_RS08460	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4F37_RS08480	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F37_RS08485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4F37_RS08505	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4F37_RS08510	COG1704	LemA family
E4F37_RS08630	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS08650	COG2824	Alkylphosphonate utilization operon protein PhnA
E4F37_RS08680	COG0583	DNA-binding transcription factor activity
E4F37_RS08690	COG2233	PERMEase
E4F37_RS08700	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4F37_RS08710	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
E4F37_RS08720	COG1706	bacterial-type flagellum-dependent cell motility
E4F37_RS08725	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E4F37_RS08740	COG1749	Flagellar hook protein flgE
E4F37_RS08745	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4F37_RS08750	COG1558	bacterial-type flagellum-dependent cell motility
E4F37_RS08755	COG1815	bacterial-type flagellum-dependent cell motility
E4F37_RS08765	COG2747	anti-sigma28 factor FlgM
E4F37_RS08810	COG0741	lytic transglycosylase activity
E4F37_RS08815	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4F37_RS08825	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E4F37_RS08830	COG1984	allophanate hydrolase subunit 2
E4F37_RS08860	COG4608	Belongs to the ABC transporter superfamily
E4F37_RS08865	COG0444	Belongs to the ABC transporter superfamily
E4F37_RS08870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4F37_RS08875	COG0601	transmembrane transport
E4F37_RS08880	COG0747	negative chemotaxis
E4F37_RS08900	COG0579	oxidoreductase
E4F37_RS08920	COG3568	Endonuclease Exonuclease Phosphatase
E4F37_RS08925	COG1280	lysine exporter protein (LysE YggA)
E4F37_RS08945	COG0531	amino acid
E4F37_RS08960	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4F37_RS09020	COG1960	acyl-CoA dehydrogenase activity
E4F37_RS09035	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4F37_RS09045	COG2814	Major facilitator Superfamily
E4F37_RS09065	COG0667	Aldo Keto reductase
E4F37_RS09095	COG1560	Kdo2-lipid A biosynthetic process
E4F37_RS09110	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E4F37_RS09120	COG0523	cobalamin synthesis protein
E4F37_RS09150	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E4F37_RS09180	COG1309	transcriptional regulator
E4F37_RS09195	COG2814	Major facilitator Superfamily
E4F37_RS09205	COG2207	Transcriptional regulator
E4F37_RS09210	COG1064	alcohol dehydrogenase
E4F37_RS09220	COG0708	Exodeoxyribonuclease III
E4F37_RS09225	COG2326	polyphosphate kinase activity
E4F37_RS09230	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4F37_RS09245	COG1077	Cell shape determining protein MreB Mrl
E4F37_RS09260	COG0768	penicillin binding
E4F37_RS09265	COG0772	Belongs to the SEDS family
E4F37_RS09290	COG0720	synthase
E4F37_RS09295	COG0602	queuosine metabolic process
E4F37_RS09315	COG2204	response regulator
E4F37_RS09320	COG5000	phosphorelay sensor kinase activity
E4F37_RS09350	COG0242	peptide deformylase activity
E4F37_RS09355	COG0758	DNA mediated transformation
E4F37_RS09375	COG0583	DNA-binding transcription factor activity
E4F37_RS09380	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4F37_RS09435	COG4695	Portal protein
E4F37_RS09450	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4F37_RS09465	COG0583	DNA-binding transcription factor activity
E4F37_RS09495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4F37_RS09510	COG2169	Transcriptional regulator
E4F37_RS09510	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4F37_RS09540	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4F37_RS09625	COG0582	viral genome integration into host DNA
E4F37_RS09665	COG0592	DNA-directed DNA polymerase activity
E4F37_RS09690	COG0753	catalase activity
E4F37_RS09735	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4F37_RS09740	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4F37_RS09740	COG1024	Enoyl-CoA hydratase
E4F37_RS09745	COG0183	Belongs to the thiolase family
E4F37_RS09755	COG1960	acyl-CoA dehydrogenase activity
E4F37_RS09790	COG1695	Transcriptional regulator
E4F37_RS09870	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS09895	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS09910	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4F37_RS09920	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4F37_RS09930	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4F37_RS09930	COG4106	trans-aconitate 2-methyltransferase activity
E4F37_RS09935	COG0789	Transcriptional regulator
E4F37_RS09945	COG1987	bacterial-type flagellum assembly
E4F37_RS09960	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4F37_RS09980	COG1346	cytolysis
E4F37_RS09990	COG0583	DNA-binding transcription factor activity
E4F37_RS09995	COG2814	Major facilitator Superfamily
E4F37_RS10000	COG1846	Transcriptional regulator
E4F37_RS10020	COG2801	Transposase and inactivated derivatives
E4F37_RS10055	COG2165	general secretion pathway protein
E4F37_RS10075	COG1459	type II secretion system
E4F37_RS10100	COG0523	cobalamin synthesis protein
E4F37_RS10145	COG0519	Catalyzes the synthesis of GMP from XMP
E4F37_RS10145	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4F37_RS10150	COG1902	pentaerythritol trinitrate reductase activity
E4F37_RS10170	COG0642	Histidine kinase
E4F37_RS10190	COG3186	Phenylalanine-4-hydroxylase
E4F37_RS10195	COG1522	sequence-specific DNA binding
E4F37_RS10210	COG0583	DNA-binding transcription factor activity
E4F37_RS10225	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E4F37_RS10255	COG0559	Belongs to the binding-protein-dependent transport system permease family
E4F37_RS10300	COG1192	Involved in chromosome partitioning
E4F37_RS10305	COG1475	DNA binding
E4F37_RS10310	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4F37_RS10320	COG0356	it plays a direct role in the translocation of protons across the membrane
E4F37_RS10360	COG0318	PFAM AMP-dependent synthetase and ligase
E4F37_RS10380	COG1832	CoA-binding protein
E4F37_RS10400	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4F37_RS10420	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4F37_RS10420	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4F37_RS10420	COG0506	proline dehydrogenase activity
E4F37_RS10435	COG1960	acyl-CoA dehydrogenase activity
E4F37_RS10455	COG0436	Aminotransferase
E4F37_RS10470	COG0277	FAD linked oxidase domain protein
E4F37_RS10480	COG0789	Transcriptional regulator
E4F37_RS10500	COG0668	transmembrane transport
E4F37_RS10520	COG0531	amino acid
E4F37_RS10530	COG4302	ethanolamine ammonia-lyase activity
E4F37_RS10540	COG1012	belongs to the aldehyde dehydrogenase family
E4F37_RS10570	COG1760	l-serine dehydratase
E4F37_RS10595	COG0509	glycine decarboxylation via glycine cleavage system
E4F37_RS10615	COG0673	inositol 2-dehydrogenase activity
E4F37_RS10635	COG0210	DNA helicase
E4F37_RS10640	COG3245	cytochrome
E4F37_RS10660	COG0582	viral genome integration into host DNA
E4F37_RS10705	COG3397	chitin binding
E4F37_RS10730	COG2267	carboxylic ester hydrolase activity
E4F37_RS10805	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS10820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4F37_RS10860	COG0519	Catalyzes the synthesis of GMP from XMP
E4F37_RS10870	COG0561	phosphatase activity
E4F37_RS10875	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4F37_RS10890	COG0438	transferase activity, transferring glycosyl groups
E4F37_RS10915	COG1360	Flagellar Motor Protein
E4F37_RS10920	COG2201	protein-glutamate methylesterase activity
E4F37_RS10940	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4F37_RS10950	COG2201	protein-glutamate methylesterase activity
E4F37_RS10960	COG0745	RESPONSE REGULATOR receiver
E4F37_RS10965	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E4F37_RS10985	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4F37_RS10990	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4F37_RS11015	COG1950	PFAM Membrane protein of
E4F37_RS11020	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E4F37_RS11040	COG2070	2-Nitropropane dioxygenase
E4F37_RS11075	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4F37_RS11080	COG1522	sequence-specific DNA binding
E4F37_RS11090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4F37_RS11115	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4F37_RS11120	COG2823	Periplasmic or secreted lipoprotein
E4F37_RS11135	COG1113	amino acid transport
E4F37_RS11180	COG2084	Dehydrogenase
E4F37_RS11185	COG1280	lysine exporter protein (LysE YggA)
E4F37_RS11195	COG0583	DNA-binding transcription factor activity
E4F37_RS11200	COG3047	cAMP biosynthetic process
E4F37_RS11220	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E4F37_RS11235	COG1881	PFAM PEBP family protein
E4F37_RS11240	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4F37_RS11250	COG0281	malic enzyme
E4F37_RS11250	COG0280	phosphate acetyltransferase
E4F37_RS11280	COG1522	sequence-specific DNA binding
E4F37_RS11300	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4F37_RS11305	COG2151	metal-sulfur cluster biosynthetic enzyme
E4F37_RS11310	COG3396	Phenylacetate-CoA oxygenase
E4F37_RS11315	COG3460	Phenylacetate-CoA oxygenase
E4F37_RS11320	COG3396	Phenylacetate-CoA oxygenase
E4F37_RS11405	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4F37_RS11445	COG0514	ATP-dependent DNA helicase (RecQ)
E4F37_RS11580	COG0201	protein transport
E4F37_RS11625	COG4232	protein-disulfide reductase activity
E4F37_RS11645	COG1333	cytochrome c biogenesis protein
E4F37_RS11650	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4F37_RS11655	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E4F37_RS11660	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E4F37_RS11715	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E4F37_RS11725	COG1175	transmembrane transport
E4F37_RS11730	COG0395	ABC-type sugar transport system, permease component
E4F37_RS11735	COG3842	ATPase activity
E4F37_RS11740	COG0584	glycerophosphoryl diester phosphodiesterase
E4F37_RS11755	COG0069	glutamate synthase activity
E4F37_RS11755	COG0070	glutamate synthase
E4F37_RS11755	COG0067	glutamate synthase
E4F37_RS11770	COG1115	amino acid carrier protein
E4F37_RS11785	COG4178	(ABC) transporter
E4F37_RS11810	COG1127	ABC transporter
E4F37_RS11815	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4F37_RS11820	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4F37_RS11845	COG1131	(ABC) transporter
E4F37_RS11850	COG0842	Transport permease protein
E4F37_RS11875	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4F37_RS11885	COG2095	MarC family integral membrane protein
E4F37_RS11935	COG0805	protein transport
E4F37_RS11945	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4F37_RS11950	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4F37_RS11955	COG0723	plastoquinol--plastocyanin reductase activity
E4F37_RS11960	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E4F37_RS11965	COG2857	Cytochrome c1
E4F37_RS11970	COG0625	glutathione transferase activity
E4F37_RS11975	COG2969	positive regulation of protein catabolic process
E4F37_RS11990	COG0464	growth
E4F37_RS12000	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E4F37_RS12005	COG2801	Transposase and inactivated derivatives
E4F37_RS12175	COG0308	aminopeptidase N
E4F37_RS12260	COG0443	Heat shock 70 kDa protein
E4F37_RS12270	COG1278	Cold shock
E4F37_RS12275	COG0531	amino acid
E4F37_RS12280	COG3384	dioxygenase
E4F37_RS12290	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4F37_RS12295	COG2890	protein-(glutamine-N5) methyltransferase activity
E4F37_RS12325	COG0006	proline dipeptidase activity
E4F37_RS12330	COG1335	isochorismatase
E4F37_RS12345	COG0488	(ABC) transporter
E4F37_RS12360	COG0584	glycerophosphoryl diester phosphodiesterase
E4F37_RS12405	COG0012	GTP binding
E4F37_RS12435	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4F37_RS12440	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4F37_RS12455	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E4F37_RS12475	COG0512	Glutamine amidotransferase of anthranilate synthase
E4F37_RS12490	COG0546	phosphoglycolate phosphatase activity
E4F37_RS12495	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4F37_RS12505	COG2967	ApaG domain
E4F37_RS12515	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E4F37_RS12525	COG2050	protein possibly involved in aromatic compounds catabolism
E4F37_RS12530	COG1024	Enoyl-CoA hydratase
E4F37_RS12535	COG0183	Belongs to the thiolase family
E4F37_RS12545	COG1024	Enoyl-CoA hydratase
E4F37_RS12595	COG0243	molybdopterin cofactor binding
E4F37_RS12600	COG0318	PFAM AMP-dependent synthetase and ligase
E4F37_RS12605	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS12620	COG0275	rRNA processing
E4F37_RS12625	COG3116	cell division
E4F37_RS12635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4F37_RS12640	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4F37_RS12675	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4F37_RS12695	COG0678	peroxiredoxin activity
E4F37_RS12720	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E4F37_RS12730	COG0494	nUDIX hydrolase
E4F37_RS12735	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E4F37_RS12760	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4F37_RS12765	COG4536	flavin adenine dinucleotide binding
E4F37_RS12775	COG0142	geranyltranstransferase activity
E4F37_RS12830	COG2095	MarC family integral membrane protein
E4F37_RS12835	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E4F37_RS12840	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4F37_RS12895	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4F37_RS12900	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E4F37_RS12910	COG2264	protein methyltransferase activity
E4F37_RS12915	COG0439	Biotin carboxylase
E4F37_RS12920	COG0511	ligase activity, forming carbon-carbon bonds
E4F37_RS12925	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E4F37_RS12930	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4F37_RS12940	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4F37_RS12945	COG3150	esterase
E4F37_RS12950	COG0557	exoribonuclease II activity
E4F37_RS12955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4F37_RS12960	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4F37_RS12980	COG1414	Transcriptional regulator
E4F37_RS12985	COG3734	2-keto-3-deoxy-galactonokinase
E4F37_RS12995	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS13010	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F37_RS13015	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS13025	COG0284	orotidine-5'-phosphate decarboxylase activity
E4F37_RS13030	COG1546	Belongs to the CinA family
E4F37_RS13035	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4F37_RS13070	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4F37_RS13080	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E4F37_RS13085	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4F37_RS13090	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4F37_RS13100	COG2814	Major facilitator Superfamily
E4F37_RS13115	COG0583	DNA-binding transcription factor activity
E4F37_RS13130	COG1301	dicarboxylic acid transport
E4F37_RS13135	COG4266	Belongs to the allantoicase family
E4F37_RS13140	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E4F37_RS13145	COG0735	belongs to the Fur family
E4F37_RS13150	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4F37_RS13180	COG1466	dna polymerase III delta subunit
E4F37_RS13185	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E4F37_RS13190	COG1981	membrane
E4F37_RS13205	COG1737	Transcriptional regulator
E4F37_RS13205	COG0837	glucose binding
E4F37_RS13220	COG0800	Aldolase
E4F37_RS13240	COG2223	nitrite transmembrane transporter activity
E4F37_RS13245	COG0583	DNA-binding transcription factor activity
E4F37_RS13255	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4F37_RS13260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F37_RS13265	COG0765	amino acid transport
E4F37_RS13270	COG0765	amino acid transport
E4F37_RS13275	COG1126	abc transporter atp-binding protein
E4F37_RS13325	COG0121	glutamine amidotransferase
E4F37_RS13335	COG0418	dihydroorotase activity
E4F37_RS13375	COG4977	sequence-specific DNA binding
E4F37_RS13375	COG1917	Cupin 2, conserved barrel domain protein
E4F37_RS13380	COG0625	glutathione transferase activity
E4F37_RS13385	COG0625	glutathione transferase activity
E4F37_RS13400	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4F37_RS13410	COG0588	phosphoglycerate mutase activity
E4F37_RS13450	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E4F37_RS13455	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4F37_RS13460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4F37_RS13465	COG0006	proline dipeptidase activity
E4F37_RS13475	COG0625	glutathione transferase activity
E4F37_RS13480	COG0069	glutamate synthase activity
E4F37_RS13570	COG3008	intermembrane lipid transfer
E4F37_RS13570	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4F37_RS13575	COG2995	paraquat-inducible protein a
E4F37_RS13595	COG2353	YceI-like domain
E4F37_RS13600	COG2353	YceI-like domain
E4F37_RS13620	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4F37_RS13625	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4F37_RS13630	COG1862	Preprotein translocase
E4F37_RS13635	COG0343	queuine tRNA-ribosyltransferase activity
E4F37_RS13650	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4F37_RS13675	COG0783	Belongs to the Dps family
E4F37_RS13700	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E4F37_RS13705	COG2188	Transcriptional regulator
E4F37_RS13715	COG3624	Phosphonate C-P lyase system protein PhnG
E4F37_RS13725	COG3626	phosphonate metabolism
E4F37_RS13730	COG3627	carbon phosphorus lyase activity
E4F37_RS13735	COG4107	phosphonate C-P lyase system protein PhnK
E4F37_RS13740	COG4778	phosphonate C-P lyase system protein PhnL
E4F37_RS13745	COG3454	Phosphonate metabolism
E4F37_RS13750	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4F37_RS13755	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E4F37_RS13760	COG3639	organic phosphonate transmembrane transporter activity
E4F37_RS13780	COG0247	lactate metabolic process
E4F37_RS13785	COG0277	FAD linked oxidase domain protein
E4F37_RS13790	COG0277	FAD linked oxidase domain protein
E4F37_RS13795	COG0277	FAD linked oxidase domain protein
E4F37_RS13800	COG2096	Adenosyltransferase
E4F37_RS13805	COG1017	nitric oxide dioxygenase activity
E4F37_RS13805	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4F37_RS13815	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4F37_RS13825	COG0312	modulator of DNA gyrase
E4F37_RS13830	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4F37_RS13835	COG3164	Protein of unknown function
E4F37_RS13840	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E4F37_RS13845	COG0497	DNA recombination
E4F37_RS13850	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4F37_RS13890	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4F37_RS13900	COG1428	Deoxynucleoside kinase
E4F37_RS13905	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4F37_RS13910	COG0617	tRNA 3'-terminal CCA addition
E4F37_RS13920	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4F37_RS13950	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4F37_RS13955	COG0586	Pfam SNARE associated Golgi protein
E4F37_RS14055	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4F37_RS14070	COG1368	sulfuric ester hydrolase activity
E4F37_RS14075	COG3321	synthase
E4F37_RS14075	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS14075	COG0604	alcohol dehydrogenase
E4F37_RS14080	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E4F37_RS14085	COG0156	8-amino-7-oxononanoate synthase activity
E4F37_RS14135	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4F37_RS14140	COG3206	protein involved in exopolysaccharide biosynthesis
E4F37_RS14140	COG0489	protein tyrosine kinase activity
E4F37_RS14150	COG3562	capsule polysaccharide
E4F37_RS14155	COG1045	serine acetyltransferase
E4F37_RS14170	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E4F37_RS14175	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4F37_RS14180	COG0517	IMP dehydrogenase activity
E4F37_RS14180	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4F37_RS14215	COG2885	chlorophyll binding
E4F37_RS14240	COG0824	Thioesterase
E4F37_RS14245	COG4221	oxidoreductase activity
E4F37_RS14305	COG0450	alkyl hydroperoxide reductase
E4F37_RS14315	COG1960	acyl-CoA dehydrogenase activity
E4F37_RS14350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4F37_RS14360	COG2814	Major facilitator Superfamily
E4F37_RS14390	COG2814	Major facilitator Superfamily
E4F37_RS14395	COG0778	Nitroreductase
E4F37_RS14400	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4F37_RS14405	COG0583	DNA-binding transcription factor activity
E4F37_RS14415	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4F37_RS14450	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4F37_RS14475	COG4774	siderophore transport
E4F37_RS14480	COG1120	ATPase activity
E4F37_RS14490	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4F37_RS14535	COG0730	response to heat
E4F37_RS14550	COG0584	glycerophosphoryl diester phosphodiesterase
E4F37_RS14560	COG1280	lysine exporter protein (LysE YggA)
E4F37_RS14620	COG0604	alcohol dehydrogenase
E4F37_RS14625	COG1733	regulation of RNA biosynthetic process
E4F37_RS14640	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4F37_RS14660	COG1773	rubredoxin
E4F37_RS14680	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E4F37_RS14755	COG1215	transferase activity, transferring glycosyl groups
E4F37_RS14770	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4F37_RS14785	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4F37_RS14815	COG0859	PFAM glycosyl transferase family 9
E4F37_RS14870	COG1129	ABC transporter
E4F37_RS14880	COG0559	Belongs to the binding-protein-dependent transport system permease family
E4F37_RS14895	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4F37_RS14905	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E4F37_RS14915	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4F37_RS14955	COG2226	methyltransferase
E4F37_RS14985	COG0762	integral membrane protein
E4F37_RS15020	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4F37_RS15035	COG0436	Aminotransferase
E4F37_RS15065	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4F37_RS15065	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4F37_RS15090	COG2814	Major facilitator Superfamily
E4F37_RS15105	COG1126	abc transporter atp-binding protein
E4F37_RS15110	COG0765	amino acid transport
E4F37_RS15115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F37_RS15130	COG0363	glucosamine-6-phosphate deaminase activity
E4F37_RS15135	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E4F37_RS15145	COG1175	transmembrane transport
E4F37_RS15150	COG0395	ABC-type sugar transport system, permease component
E4F37_RS15155	COG3842	ATPase activity
E4F37_RS15160	COG2860	membrane
E4F37_RS15165	COG1193	negative regulation of DNA recombination
E4F37_RS15170	COG0492	ferredoxin-NADP+ reductase activity
E4F37_RS15175	COG1674	ftsk spoiiie
E4F37_RS15180	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4F37_RS15185	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4F37_RS15230	COG2894	cell division
E4F37_RS15250	COG0859	PFAM glycosyl transferase family 9
E4F37_RS15260	COG0477	Major facilitator Superfamily
E4F37_RS15295	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4F37_RS15300	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4F37_RS15310	COG1561	YicC-like family, N-terminal region
E4F37_RS15325	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4F37_RS15355	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS15365	COG1278	Cold shock
E4F37_RS15370	COG2176	DNA-directed DNA polymerase activity
E4F37_RS15390	COG4772	TonB-dependent receptor
E4F37_RS15450	COG0583	DNA-binding transcription factor activity
E4F37_RS15460	COG0308	aminopeptidase N
E4F37_RS15475	COG2119	membrane
E4F37_RS15485	COG0402	S-adenosylhomocysteine deaminase activity
E4F37_RS15490	COG2252	PERMEase
E4F37_RS15495	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4F37_RS15515	COG0154	amidase activity
E4F37_RS15525	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4F37_RS15565	COG3383	formate dehydrogenase (NAD+) activity
E4F37_RS15580	COG1910	domain protein
E4F37_RS15590	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4F37_RS15605	COG0546	phosphoglycolate phosphatase activity
E4F37_RS15635	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E4F37_RS15640	COG0077	Prephenate dehydratase
E4F37_RS15640	COG1605	Chorismate mutase
E4F37_RS15650	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4F37_RS15675	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E4F37_RS15685	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4F37_RS15710	COG2951	lytic endotransglycosylase activity
E4F37_RS15715	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4F37_RS15725	COG2267	carboxylic ester hydrolase activity
E4F37_RS15735	COG2011	ABC-type metal ion transport system permease component
E4F37_RS15755	COG1960	acyl-CoA dehydrogenase activity
E4F37_RS15840	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E4F37_RS15855	COG0501	Belongs to the peptidase M48B family
E4F37_RS15865	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4F37_RS15870	COG3028	Belongs to the UPF0307 family
E4F37_RS15880	COG0312	modulator of DNA gyrase
E4F37_RS15895	COG2204	response regulator
E4F37_RS15925	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E4F37_RS15935	COG0640	Transcriptional regulator
E4F37_RS15960	COG0114	fumarate hydratase activity
E4F37_RS15975	COG0534	Mate efflux family protein
E4F37_RS15980	COG2501	S4 domain
E4F37_RS16000	COG3045	CreA protein
E4F37_RS16015	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4F37_RS16025	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4F37_RS16045	COG1322	Protein conserved in bacteria
E4F37_RS16060	COG0303	'Molybdopterin
E4F37_RS16070	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4F37_RS16075	COG1530	ribonuclease E activity
E4F37_RS16090	COG0546	phosphoglycolate phosphatase activity
E4F37_RS16115	COG1399	metal-binding, possibly nucleic acid-binding protein
E4F37_RS16155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4F37_RS16175	COG3026	antisigma factor binding
E4F37_RS16180	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4F37_RS16195	COG0681	Belongs to the peptidase S26 family
E4F37_RS16200	COG0571	ribonuclease III activity
E4F37_RS16205	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4F37_RS16230	COG2204	response regulator
E4F37_RS16250	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4F37_RS16275	COG1956	GAF domain-containing protein
E4F37_RS16280	COG0583	DNA-binding transcription factor activity
E4F37_RS16295	COG2153	protein acetylation
E4F37_RS16310	COG1999	signal sequence binding
E4F37_RS16325	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E4F37_RS16330	COG1132	(ABC) transporter
E4F37_RS16335	COG0438	transferase activity, transferring glycosyl groups
E4F37_RS16350	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4F37_RS16355	COG0683	leucine binding
E4F37_RS16365	COG3511	phospholipase C
E4F37_RS16385	COG0596	Alpha beta hydrolase
E4F37_RS16395	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4F37_RS16410	COG3394	polysaccharide catabolic process
E4F37_RS16435	COG4598	ABC transporter
E4F37_RS16455	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4F37_RS16490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F37_RS16500	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4F37_RS16530	COG1959	2 iron, 2 sulfur cluster binding
E4F37_RS16545	COG2151	metal-sulfur cluster biosynthetic enzyme
E4F37_RS16550	COG0822	iron-sulfur transferase activity
E4F37_RS16555	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4F37_RS16565	COG0396	ATPase activity
E4F37_RS16570	COG0719	Fe-S assembly protein
E4F37_RS16590	COG0840	transmembrane signaling receptor activity
E4F37_RS16595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4F37_RS16600	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4F37_RS16625	COG0826	peptidase U32
E4F37_RS16630	COG0826	peptidase U32
E4F37_RS16635	COG3154	lipid carrier protein
E4F37_RS16680	COG2151	metal-sulfur cluster biosynthetic enzyme
E4F37_RS16700	COG0415	Belongs to the DNA photolyase family
E4F37_RS16705	COG0529	Catalyzes the synthesis of activated sulfate
E4F37_RS16755	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4F37_RS16770	COG0402	S-adenosylhomocysteine deaminase activity
E4F37_RS16810	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4F37_RS16815	COG0174	glutamine synthetase
E4F37_RS16845	COG0583	DNA-binding transcription factor activity
E4F37_RS16850	COG1960	acyl-CoA dehydrogenase activity
E4F37_RS16865	COG0477	Major facilitator Superfamily
E4F37_RS16875	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4F37_RS16875	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4F37_RS16880	COG1643	Atp-dependent helicase
E4F37_RS16905	COG1546	Belongs to the CinA family
E4F37_RS16905	COG1058	Belongs to the CinA family
E4F37_RS16920	COG0174	glutamine synthetase
E4F37_RS16945	COG2197	response regulator
E4F37_RS16950	COG4585	Histidine kinase
E4F37_RS16955	COG2181	nitrate reductase activity
E4F37_RS16960	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E4F37_RS16965	COG1140	nitrate reductase beta subunit
E4F37_RS16970	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E4F37_RS16975	COG2223	nitrite transmembrane transporter activity
E4F37_RS16995	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4F37_RS17000	COG0339	signal peptide processing
E4F37_RS17020	COG4566	intracellular signal transduction
E4F37_RS17030	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E4F37_RS17035	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4F37_RS17040	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4F37_RS17060	COG1414	Transcriptional regulator
E4F37_RS17085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4F37_RS17095	COG1104	cysteine desulfurase activity
E4F37_RS17100	COG0822	iron-sulfur transferase activity
E4F37_RS17105	COG0316	Belongs to the HesB IscA family
E4F37_RS17125	COG2975	iron-sulfur cluster assembly
E4F37_RS17155	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4F37_RS17175	COG1136	(ABC) transporter
E4F37_RS17180	COG0084	hydrolase, TatD family'
E4F37_RS17185	COG2333	competence protein COMEC
E4F37_RS17185	COG0658	competence protein
E4F37_RS17190	COG2267	carboxylic ester hydrolase activity
E4F37_RS17210	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E4F37_RS17220	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4F37_RS17230	COG2833	Protein of unknown function (DUF455)
E4F37_RS17240	COG0596	Alpha beta hydrolase
E4F37_RS17250	COG0613	PHP domain protein
E4F37_RS17255	COG0009	L-threonylcarbamoyladenylate synthase
E4F37_RS17260	COG1994	Peptidase M50
E4F37_RS17265	COG0180	Tryptophanyl-tRNA synthetase
E4F37_RS17275	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4F37_RS17280	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E4F37_RS17285	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4F37_RS17300	COG2850	peptidyl-arginine hydroxylation
E4F37_RS17615	COG3311	Transcriptional regulator
E4F37_RS17675	COG0483	inositol monophosphate 1-phosphatase activity
E4F37_RS17690	COG1045	serine acetyltransferase
E4F37_RS17700	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4F37_RS17710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4F37_RS17735	COG0037	tRNA processing
E4F37_RS17745	COG0527	aspartate kinase activity
E4F37_RS17805	COG0529	Catalyzes the synthesis of activated sulfate
E4F37_RS17805	COG2895	sulfate adenylyltransferase (ATP) activity
E4F37_RS17835	COG2175	clavaminate synthase activity
E4F37_RS17855	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4F37_RS17860	COG3958	Transketolase
E4F37_RS17875	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E4F37_RS17895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4F37_RS17915	COG0024	Methionine aminopeptidase
E4F37_RS17935	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4F37_RS17950	COG0243	molybdopterin cofactor binding
E4F37_RS17975	COG4166	transmembrane transport
E4F37_RS17980	COG4174	ABC transporter (Permease)
E4F37_RS17985	COG4239	(ABC) transporter, permease
E4F37_RS17990	COG4172	Belongs to the ABC transporter superfamily
E4F37_RS18000	COG0791	NLP P60 protein
E4F37_RS18005	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4F37_RS18070	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4F37_RS18080	COG0583	DNA-binding transcription factor activity
E4F37_RS18090	COG2224	Isocitrate lyase
E4F37_RS18100	COG0513	Belongs to the DEAD box helicase family
E4F37_RS18110	COG1214	PFAM Peptidase M22, glycoprotease
E4F37_RS18120	COG1573	uracil-dna glycosylase
E4F37_RS18135	COG0351	phosphomethylpyrimidine kinase
E4F37_RS18140	COG0477	Major facilitator Superfamily
E4F37_RS18160	COG0488	(ABC) transporter
E4F37_RS18165	COG0386	Belongs to the glutathione peroxidase family
E4F37_RS18180	COG2890	protein-(glutamine-N5) methyltransferase activity
E4F37_RS18190	COG1393	Belongs to the ArsC family
E4F37_RS18235	COG0242	peptide deformylase activity
E4F37_RS18240	COG1187	pseudouridine synthase activity
E4F37_RS18250	COG0024	Methionine aminopeptidase
E4F37_RS18280	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4F37_RS18295	COG0750	zinc metalloprotease
E4F37_RS18335	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4F37_RS18380	COG0330	HflC and HflK could
E4F37_RS18390	COG2867	negative regulation of translational initiation
E4F37_RS18400	COG0697	spore germination
E4F37_RS18475	COG1196	nuclear chromosome segregation
E4F37_RS18500	COG2814	Major facilitator Superfamily
E4F37_RS18540	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4F37_RS18550	COG1953	Uracil, thiamine, allantoin
E4F37_RS18565	COG3195	allantoin biosynthetic process
E4F37_RS18565	COG3648	Uricase
E4F37_RS18570	COG4266	Belongs to the allantoicase family
E4F37_RS18590	COG2351	hydroxyisourate hydrolase activity
E4F37_RS18605	COG0583	DNA-binding transcription factor activity
E4F37_RS18615	COG3360	Dodecin
E4F37_RS18710	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4F37_RS18725	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4F37_RS18860	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4F37_RS18870	COG1846	Transcriptional regulator
E4F37_RS18875	COG1929	Belongs to the glycerate kinase type-1 family
E4F37_RS18900	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4F37_RS18980	COG4181	ATPase activity
E4F37_RS18995	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4F37_RS19005	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4F37_RS19005	COG0047	phosphoribosylformylglycinamidine synthase activity
E4F37_RS19015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4F37_RS19040	COG0318	PFAM AMP-dependent synthetase and ligase
E4F37_RS19050	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4F37_RS19050	COG1024	Enoyl-CoA hydratase
E4F37_RS19055	COG1335	isochorismatase
E4F37_RS19060	COG0183	Belongs to the thiolase family
E4F37_RS19090	COG2130	NADP-dependent
E4F37_RS19095	COG0657	acetylesterase activity
E4F37_RS19110	COG0354	folic acid binding
E4F37_RS19115	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4F37_RS19130	COG1247	-acetyltransferase
E4F37_RS19135	COG0084	hydrolase, TatD family'
E4F37_RS19165	COG0438	transferase activity, transferring glycosyl groups
E4F37_RS19200	COG0252	asparaginase activity
E4F37_RS19210	COG1652	LysM domain
E4F37_RS19220	COG2084	Dehydrogenase
E4F37_RS19225	COG3622	Belongs to the hyi family
E4F37_RS19230	COG3960	tartronate-semialdehyde synthase activity
E4F37_RS19235	COG0583	DNA-binding transcription factor activity
E4F37_RS19250	COG1595	DNA-templated transcription, initiation
E4F37_RS19295	COG0306	phosphate transporter
E4F37_RS19305	COG0791	NLP P60 protein
E4F37_RS19310	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E4F37_RS19320	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4F37_RS19325	COG0726	polysaccharide deacetylase
E4F37_RS19330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4F37_RS19330	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4F37_RS19340	COG0463	Glycosyl transferase, family 2
E4F37_RS19345	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4F37_RS19350	COG2076	Multidrug Resistance protein
E4F37_RS19355	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4F37_RS19365	COG0436	Aminotransferase
E4F37_RS19400	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E4F37_RS19405	COG0314	molybdopterin synthase activity
E4F37_RS19410	COG2346	COG2346, Truncated hemoglobins
E4F37_RS19415	COG1959	2 iron, 2 sulfur cluster binding
E4F37_RS19420	COG0542	response to heat
E4F37_RS19450	COG0534	Mate efflux family protein
E4F37_RS19470	COG3228	Belongs to the MtfA family
E4F37_RS19475	COG0477	Major facilitator Superfamily
E4F37_RS19480	COG0789	Transcriptional regulator
E4F37_RS19485	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4F37_RS19510	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4F37_RS19525	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4F37_RS19570	COG0670	Belongs to the BI1 family
E4F37_RS19605	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4F37_RS19620	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4F37_RS19625	COG0330	HflC and HflK could
E4F37_RS19630	COG0330	HflC and HflK could
E4F37_RS19655	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E4F37_RS19670	COG3547	Transposase (IS116 IS110 IS902 family)
E4F37_RS19680	COG2183	response to ionizing radiation
E4F37_RS19695	COG1199	ATP-dependent helicase activity
E4F37_RS19710	COG0564	pseudouridine synthase activity
E4F37_RS19720	COG3243	poly(R)-hydroxyalkanoic acid synthase
E4F37_RS19725	COG0183	Belongs to the thiolase family
E4F37_RS19730	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS19755	COG0183	Belongs to the thiolase family
E4F37_RS19765	COG0626	cystathionine gamma-synthase activity
E4F37_RS19770	COG0560	Phosphoserine phosphatase
E4F37_RS19790	COG0390	transport system, permease component
E4F37_RS19795	COG1122	ATPase activity
E4F37_RS19800	COG2982	Protein involved in outer membrane biogenesis
E4F37_RS19810	COG0488	(ABC) transporter
E4F37_RS19830	COG2070	2-Nitropropane dioxygenase
E4F37_RS19835	COG3047	cAMP biosynthetic process
E4F37_RS19850	COG1914	H( )-stimulated, divalent metal cation uptake system
E4F37_RS19855	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4F37_RS19860	COG3842	ATPase activity
E4F37_RS19865	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F37_RS19870	COG1177	transmembrane transport
E4F37_RS19880	COG0730	response to heat
E4F37_RS19880	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4F37_RS19905	COG3655	Transcriptional regulator
E4F37_RS19930	COG1538	Outer membrane efflux protein
E4F37_RS19935	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F37_RS19950	COG0038	chloride channel
E4F37_RS19955	COG2855	membrane
E4F37_RS19975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4F37_RS19985	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4F37_RS19995	COG1609	Transcriptional regulator
E4F37_RS20085	COG0598	Magnesium transport protein CorA
E4F37_RS20125	COG1196	nuclear chromosome segregation
E4F37_RS20125	COG3264	Mechanosensitive ion channel
E4F37_RS20160	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E4F37_RS20175	COG4263	nitrous-oxide reductase activity
E4F37_RS20200	COG0840	transmembrane signaling receptor activity
E4F37_RS20210	COG2376	Dihydroxyacetone kinase
E4F37_RS20230	COG0475	glutathione-regulated potassium exporter activity
E4F37_RS20320	COG1414	Transcriptional regulator
E4F37_RS20345	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4F37_RS20375	COG2274	protein secretion by the type I secretion system
E4F37_RS20380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4F37_RS20390	COG0859	PFAM glycosyl transferase family 9
E4F37_RS20390	COG0457	Tetratricopeptide repeat
E4F37_RS20395	COG0529	Catalyzes the synthesis of activated sulfate
E4F37_RS20405	COG0745	RESPONSE REGULATOR receiver
E4F37_RS20435	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS20445	COG2986	histidine ammonia-lyase
E4F37_RS20455	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4F37_RS20470	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4F37_RS20495	COG1595	DNA-templated transcription, initiation
E4F37_RS20520	COG3220	belongs to the UPF0276 family
E4F37_RS20550	COG2192	nodulation
E4F37_RS20575	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4F37_RS20595	COG0165	Argininosuccinate lyase
E4F37_RS20600	COG0137	argininosuccinate synthase activity
E4F37_RS20615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4F37_RS20625	COG3251	PFAM MbtH domain protein
E4F37_RS20645	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS20655	COG2207	Transcriptional regulator
E4F37_RS20665	COG0697	spore germination
E4F37_RS20670	COG0835	chemotaxis
E4F37_RS20700	COG0477	Major facilitator Superfamily
E4F37_RS20720	COG1732	Glycine betaine
E4F37_RS20725	COG1174	glycine betaine transport
E4F37_RS20730	COG1125	glycine betaine transport
E4F37_RS20735	COG1174	glycine betaine transport
E4F37_RS20760	COG2235	arginine
E4F37_RS20765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4F37_RS20780	COG1621	beta-fructofuranosidase activity
E4F37_RS20790	COG1566	PFAM secretion protein HlyD family protein
E4F37_RS20815	COG2814	Major facilitator Superfamily
E4F37_RS20980	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E4F37_RS20980	COG0028	Belongs to the TPP enzyme family
E4F37_RS20985	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4F37_RS20995	COG4977	sequence-specific DNA binding
E4F37_RS21015	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F37_RS21020	COG1305	Transglutaminase-like
E4F37_RS21050	COG2308	Evidence 4 Homologs of previously reported genes of
E4F37_RS21060	COG0778	Nitroreductase
E4F37_RS21085	COG3634	alkyl hydroperoxide reductase activity
E4F37_RS21115	COG0318	PFAM AMP-dependent synthetase and ligase
E4F37_RS21135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4F37_RS21170	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4F37_RS21180	COG0010	Belongs to the arginase family
E4F37_RS21185	COG1012	belongs to the aldehyde dehydrogenase family
E4F37_RS21190	COG1917	Cupin 2, conserved barrel domain protein
E4F37_RS21190	COG1396	sequence-specific DNA binding
E4F37_RS21205	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4F37_RS21210	COG0174	glutamine synthetase
E4F37_RS21225	COG3842	ATPase activity
E4F37_RS21230	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F37_RS21235	COG1177	transmembrane transport
E4F37_RS21245	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4F37_RS21250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4F37_RS21295	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E4F37_RS21295	COG1796	DNA polymerase
E4F37_RS21330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F37_RS21340	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4F37_RS21390	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E4F37_RS21400	COG1335	isochorismatase
E4F37_RS21405	COG0583	DNA-binding transcription factor activity
E4F37_RS21415	COG2814	Major facilitator Superfamily
E4F37_RS21455	COG1741	Belongs to the pirin family
E4F37_RS21460	COG0583	DNA-binding transcription factor activity
E4F37_RS21510	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4F37_RS21560	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4F37_RS21760	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4F37_RS21795	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4F37_RS21845	COG3193	protein, possibly involved in utilization of glycolate and propanediol
E4F37_RS21855	COG0672	)-iron permease
E4F37_RS21860	COG4633	Protein conserved in bacteria
E4F37_RS21870	COG0556	nucleotide-excision repair
E4F37_RS21885	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS21890	COG0667	Aldo Keto reductase
E4F37_RS21895	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4F37_RS21910	COG0789	Transcriptional regulator
E4F37_RS21965	COG1012	belongs to the aldehyde dehydrogenase family
E4F37_RS21980	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F37_RS22005	COG2271	Major facilitator Superfamily
E4F37_RS22010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4F37_RS22015	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E4F37_RS22060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4F37_RS22075	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4F37_RS22085	COG0531	amino acid
E4F37_RS22095	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E4F37_RS22120	COG2259	Doxx family
E4F37_RS22130	COG1620	l-lactate permease
E4F37_RS22135	COG1556	Lactate utilization protein
E4F37_RS22140	COG1139	Iron-sulfur cluster binding protein
E4F37_RS22145	COG0247	lactate metabolic process
E4F37_RS22150	COG2186	Transcriptional regulator
E4F37_RS22180	COG2011	ABC-type metal ion transport system permease component
E4F37_RS22185	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4F37_RS22205	COG2197	response regulator
E4F37_RS22255	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4F37_RS22265	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4F37_RS22265	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F37_RS22265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4F37_RS22265	COG3321	synthase
E4F37_RS22265	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS22270	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E4F37_RS22280	COG0019	diaminopimelate decarboxylase activity
E4F37_RS22285	COG0318	PFAM AMP-dependent synthetase and ligase
E4F37_RS22330	COG1301	dicarboxylic acid transport
E4F37_RS22345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4F37_RS22350	COG0657	acetylesterase activity
E4F37_RS22355	COG0583	DNA-binding transcription factor activity
E4F37_RS22390	COG1942	4-Oxalocrotonate Tautomerase
E4F37_RS22395	COG0583	DNA-binding transcription factor activity
E4F37_RS22400	COG0709	Synthesizes selenophosphate from selenide and ATP
E4F37_RS22435	COG1414	Transcriptional regulator
E4F37_RS22440	COG1288	antiporter activity
E4F37_RS22450	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4F37_RS22490	COG0840	transmembrane signaling receptor activity
E4F37_RS22505	COG0183	Belongs to the thiolase family
E4F37_RS22515	COG1414	Transcriptional regulator
E4F37_RS22520	COG1309	transcriptional regulator
E4F37_RS22540	COG1473	amidohydrolase
E4F37_RS22545	COG0583	DNA-binding transcription factor activity
E4F37_RS22560	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4F37_RS22560	COG2755	lipolytic protein G-D-S-L family
E4F37_RS22590	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS22625	COG2376	Dihydroxyacetone kinase
E4F37_RS22630	COG1063	alcohol dehydrogenase
E4F37_RS22635	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS22640	COG1879	ABC-type sugar transport system periplasmic component
E4F37_RS22645	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F37_RS22650	COG1129	ABC transporter
E4F37_RS22655	COG0698	ribose 5-phosphate isomerase
E4F37_RS22665	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS22680	COG1840	ABC-type Fe3 transport system, periplasmic component
E4F37_RS22685	COG3842	ATPase activity
E4F37_RS22715	COG3720	iron ion transport
E4F37_RS22720	COG4558	Periplasmic binding protein
E4F37_RS22730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4F37_RS22735	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E4F37_RS22740	COG2860	membrane
E4F37_RS22760	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E4F37_RS22770	COG1271	oxidase subunit
E4F37_RS22775	COG1294	oxidase, subunit
E4F37_RS22800	COG1562	ergosterol biosynthetic process
E4F37_RS22810	COG0346	lactoylglutathione lyase activity
E4F37_RS22900	COG1285	pathogenesis
E4F37_RS22925	COG0840	transmembrane signaling receptor activity
E4F37_RS22935	COG0535	radical SAM domain protein
E4F37_RS23000	COG0840	transmembrane signaling receptor activity
E4F37_RS23060	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E4F37_RS23065	COG0511	ligase activity, forming carbon-carbon bonds
E4F37_RS23080	COG1984	allophanate hydrolase subunit 2
E4F37_RS23135	COG0583	DNA-binding transcription factor activity
E4F37_RS23250	COG2885	chlorophyll binding
E4F37_RS23290	COG0367	asparagine synthase
E4F37_RS23320	COG3537	Alpha-1,2-mannosidase
E4F37_RS23350	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS23410	COG0583	DNA-binding transcription factor activity
E4F37_RS23415	COG1473	amidohydrolase
E4F37_RS23430	COG0513	Belongs to the DEAD box helicase family
E4F37_RS23465	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F37_RS23470	COG1879	ABC-type sugar transport system periplasmic component
E4F37_RS23520	COG4251	negative regulation of phosphorylation
E4F37_RS23520	COG3706	GGDEF domain
E4F37_RS23520	COG2203	Gaf domain
E4F37_RS23520	COG5001	Diguanylate cyclase
E4F37_RS23555	COG3321	synthase
E4F37_RS23555	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS23555	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F37_RS23555	COG0318	PFAM AMP-dependent synthetase and ligase
E4F37_RS23555	COG0300	oxidoreductase activity
E4F37_RS23570	COG3835	regulator
E4F37_RS23575	COG0469	pyruvate kinase activity
E4F37_RS23580	COG1929	Belongs to the glycerate kinase type-1 family
E4F37_RS23585	COG2271	Major facilitator Superfamily
E4F37_RS23605	COG3547	Transposase (IS116 IS110 IS902 family)
E4F37_RS23630	COG3188	usher protein
E4F37_RS23770	COG2885	chlorophyll binding
E4F37_RS23785	COG3188	usher protein
E4F37_RS23790	COG3121	Chaperone
E4F37_RS23815	COG5295	Hep Hag repeat protein
E4F37_RS23845	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4F37_RS23885	COG0432	Pfam Uncharacterised protein family UPF0047
E4F37_RS23930	COG1177	transmembrane transport
E4F37_RS23935	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F37_RS24030	COG0477	Major facilitator Superfamily
E4F37_RS24045	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4F37_RS24080	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4F37_RS24085	COG1595	DNA-templated transcription, initiation
E4F37_RS24165	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4F37_RS24170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4F37_RS24175	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4F37_RS24180	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4F37_RS24200	COG0302	gtp cyclohydrolase
E4F37_RS24205	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS24215	COG1045	serine acetyltransferase
E4F37_RS24265	COG0589	response to stress
E4F37_RS24270	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4F37_RS24275	COG0583	DNA-binding transcription factor activity
E4F37_RS24350	COG0671	phosphoesterase, PA-phosphatase related
E4F37_RS24360	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS24385	COG0625	glutathione transferase activity
E4F37_RS24400	COG0583	DNA-binding transcription factor activity
E4F37_RS24405	COG0473	3-isopropylmalate dehydrogenase activity
E4F37_RS24430	COG1309	transcriptional regulator
E4F37_RS24455	COG1396	sequence-specific DNA binding
E4F37_RS24495	COG1192	Involved in chromosome partitioning
E4F37_RS24505	COG1393	Belongs to the ArsC family
E4F37_RS24515	COG1595	DNA-templated transcription, initiation
E4F37_RS24565	COG1562	ergosterol biosynthetic process
E4F37_RS24575	COG1657	PFAM Prenyltransferase squalene oxidase
E4F37_RS24590	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F37_RS24595	COG0765	amino acid transport
E4F37_RS24600	COG1126	abc transporter atp-binding protein
E4F37_RS24610	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4F37_RS24635	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS24645	COG2072	flavoprotein involved in K transport
E4F37_RS24650	COG1136	(ABC) transporter
E4F37_RS24695	COG5002	protein histidine kinase activity
E4F37_RS24695	COG3447	MASE1 domain protein
E4F37_RS24695	COG5001	Diguanylate cyclase
E4F37_RS24760	COG0456	acetyltransferase
E4F37_RS24760	COG0454	-acetyltransferase
E4F37_RS24785	COG0154	amidase activity
E4F37_RS24795	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS24860	COG3302	dmso reductase anchor subunit
E4F37_RS24865	COG0437	4 iron, 4 sulfur cluster binding
E4F37_RS24870	COG0243	molybdopterin cofactor binding
E4F37_RS24895	COG3246	L-lysine catabolic process to acetate
E4F37_RS24900	COG2175	clavaminate synthase activity
E4F37_RS24920	COG2909	trisaccharide binding
E4F37_RS24945	COG0071	Belongs to the small heat shock protein (HSP20) family
E4F37_RS24960	COG2239	Acts as a magnesium transporter
E4F37_RS25025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4F37_RS25085	COG0022	dehydrogenase e1 component
E4F37_RS25115	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4F37_RS25135	COG2091	lysine biosynthetic process via aminoadipic acid
E4F37_RS25145	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4F37_RS25150	COG2084	Dehydrogenase
E4F37_RS25165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4F37_RS25170	COG0688	phosphatidylethanolamine metabolic process
E4F37_RS25190	COG5265	(ABC) transporter
E4F37_RS25200	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS25210	COG0859	PFAM glycosyl transferase family 9
E4F37_RS25215	COG2192	nodulation
E4F37_RS25250	COG2204	response regulator
E4F37_RS25265	COG0784	Response regulator, receiver
E4F37_RS25265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F37_RS25265	COG2205	protein histidine kinase activity
E4F37_RS25265	COG2198	Histidine kinase
E4F37_RS25280	COG2823	Periplasmic or secreted lipoprotein
E4F37_RS25285	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS25310	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS25330	COG1914	H( )-stimulated, divalent metal cation uptake system
E4F37_RS25335	COG1573	uracil-dna glycosylase
E4F37_RS25355	COG0517	IMP dehydrogenase activity
E4F37_RS25355	COG0516	GMP reductase activity
E4F37_RS25445	COG3685	Protein conserved in bacteria
E4F37_RS25450	COG3546	catalase activity
E4F37_RS25460	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4F37_RS25535	COG2271	Major facilitator Superfamily
E4F37_RS25555	COG1113	amino acid transport
E4F37_RS25560	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS25575	COG1522	sequence-specific DNA binding
E4F37_RS25620	COG4964	Belongs to the GSP D family
E4F37_RS25670	COG0463	Glycosyl transferase, family 2
E4F37_RS25725	COG1966	Carbon starvation protein
E4F37_RS25730	COG2879	small protein
E4F37_RS25750	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4F37_RS25770	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4F37_RS25800	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4F37_RS25850	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4F37_RS25865	COG2801	Transposase and inactivated derivatives
E4F37_RS25900	COG3104	oligopeptide transport
E4F37_RS25925	COG0601	transmembrane transport
E4F37_RS25930	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4F37_RS25980	COG2610	gluconate transmembrane transporter activity
E4F37_RS26005	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4F37_RS26050	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4F37_RS26060	COG0583	DNA-binding transcription factor activity
E4F37_RS26065	COG0477	Major facilitator Superfamily
E4F37_RS26085	COG1104	cysteine desulfurase activity
E4F37_RS26090	COG0477	Major facilitator Superfamily
E4F37_RS26120	COG0583	DNA-binding transcription factor activity
E4F37_RS26125	COG3048	D-serine ammonia-lyase activity
E4F37_RS26135	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS26290	COG1609	Transcriptional regulator
E4F37_RS26310	COG3842	ATPase activity
E4F37_RS26315	COG1653	transport
E4F37_RS26320	COG1175	transmembrane transport
E4F37_RS26325	COG0395	ABC-type sugar transport system, permease component
E4F37_RS26350	COG3436	PFAM IS66 Orf2 family protein
E4F37_RS26360	COG0251	oxidation-reduction process
E4F37_RS26365	COG1301	dicarboxylic acid transport
E4F37_RS26395	COG3209	COG3209 Rhs family protein
E4F37_RS26455	COG0402	S-adenosylhomocysteine deaminase activity
E4F37_RS26475	COG0494	nUDIX hydrolase
E4F37_RS26540	COG1022	Amp-dependent synthetase and ligase
E4F37_RS26550	COG3246	L-lysine catabolic process to acetate
E4F37_RS26565	COG1960	acyl-CoA dehydrogenase activity
E4F37_RS26570	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4F37_RS26575	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS26585	COG1960	acyl-CoA dehydrogenase activity
E4F37_RS26605	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4F37_RS26660	COG1253	flavin adenine dinucleotide binding
E4F37_RS26665	COG0583	DNA-binding transcription factor activity
E4F37_RS26700	COG1215	transferase activity, transferring glycosyl groups
E4F37_RS26805	COG0504	CTP synthase activity
E4F37_RS26820	COG0672	)-iron permease
E4F37_RS26890	COG1404	Belongs to the peptidase S8 family
E4F37_RS26900	COG2936	dipeptidyl-peptidase activity
E4F37_RS26905	COG1573	uracil-dna glycosylase
E4F37_RS27060	COG0596	Alpha beta hydrolase
E4F37_RS27095	COG0625	glutathione transferase activity
E4F37_RS27110	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4F37_RS27115	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4F37_RS27150	COG0295	cytidine deaminase activity
E4F37_RS27160	COG2823	Periplasmic or secreted lipoprotein
E4F37_RS27185	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4F37_RS27190	COG0280	phosphate acetyltransferase
E4F37_RS27195	COG3243	poly(R)-hydroxyalkanoic acid synthase
E4F37_RS27210	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E4F37_RS27225	COG0356	it plays a direct role in the translocation of protons across the membrane
E4F37_RS27235	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4F37_RS27235	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E4F37_RS27240	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E4F37_RS27245	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E4F37_RS27265	COG0840	transmembrane signaling receptor activity
E4F37_RS27275	COG0784	Response regulator, receiver
E4F37_RS27275	COG4191	Histidine kinase
E4F37_RS27280	COG0842	Transport permease protein
E4F37_RS27285	COG0842	Transport permease protein
E4F37_RS27285	COG1129	ABC transporter
E4F37_RS27290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4F37_RS27300	COG1309	transcriptional regulator
E4F37_RS27310	COG0589	response to stress
E4F37_RS27325	COG1136	(ABC) transporter
E4F37_RS27350	COG0840	transmembrane signaling receptor activity
E4F37_RS27390	COG1611	Belongs to the LOG family
E4F37_RS27425	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4F37_RS27435	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS27445	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4F37_RS27485	COG0833	amino acid
E4F37_RS27520	COG1335	isochorismatase
E4F37_RS27540	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS27545	COG0543	2 iron, 2 sulfur cluster binding
E4F37_RS27545	COG0633	Ferredoxin
E4F37_RS27550	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E4F37_RS27555	COG4638	Rieske (2fe-2S)
E4F37_RS27560	COG0583	DNA-binding transcription factor activity
E4F37_RS27580	COG1902	pentaerythritol trinitrate reductase activity
E4F37_RS27580	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4F37_RS27600	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4F37_RS27630	COG4638	Rieske (2fe-2S)
E4F37_RS27635	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E4F37_RS27640	COG2146	nitrite reductase [NAD(P)H] activity
E4F37_RS27655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4F37_RS27670	COG2733	membrane
E4F37_RS27675	COG0025	NhaP-type Na H and K H
E4F37_RS27685	COG1012	belongs to the aldehyde dehydrogenase family
E4F37_RS27700	COG0642	Histidine kinase
E4F37_RS27705	COG0840	transmembrane signaling receptor activity
E4F37_RS27745	COG0038	chloride channel
E4F37_RS27785	COG4977	sequence-specific DNA binding
E4F37_RS27795	COG5265	(ABC) transporter
E4F37_RS27805	COG2837	iron assimilation
E4F37_RS27840	COG0583	DNA-binding transcription factor activity
E4F37_RS27865	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS27890	COG2130	NADP-dependent
E4F37_RS27925	COG0628	permease
E4F37_RS27960	COG3795	YCII-related domain
E4F37_RS27965	COG3795	YCII-related domain
E4F37_RS27975	COG4941	Belongs to the sigma-70 factor family
E4F37_RS27990	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4F37_RS28000	COG1592	Rubrerythrin
E4F37_RS28035	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4F37_RS28055	COG0489	protein tyrosine kinase activity
E4F37_RS28055	COG3206	protein involved in exopolysaccharide biosynthesis
E4F37_RS28075	COG0438	transferase activity, transferring glycosyl groups
E4F37_RS28080	COG0438	transferase activity, transferring glycosyl groups
E4F37_RS28105	COG5642	Protein of unknown function (DUF2384)
E4F37_RS28110	COG5654	RES domain protein
E4F37_RS28115	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4F37_RS28155	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F37_RS28175	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4F37_RS28190	COG4569	acetaldehyde dehydrogenase (acetylating) activity
E4F37_RS28260	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4F37_RS28265	COG0352	thiamine-phosphate diphosphorylase activity
E4F37_RS28270	COG1253	flavin adenine dinucleotide binding
E4F37_RS28285	COG0583	DNA-binding transcription factor activity
E4F37_RS28320	COG4149	molybdate abc transporter
E4F37_RS28325	COG0725	ABC transporter, periplasmic molybdate-binding protein
E4F37_RS28350	COG1764	response to oxidative stress
E4F37_RS28355	COG1846	Transcriptional regulator
E4F37_RS28380	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4F37_RS28390	COG4695	Portal protein
E4F37_RS28430	COG1683	Conserved Protein
E4F37_RS28445	COG1611	Belongs to the LOG family
E4F37_RS28455	COG1252	NADH dehydrogenase
E4F37_RS28475	COG0412	Dienelactone hydrolase
E4F37_RS28505	COG0142	geranyltranstransferase activity
E4F37_RS28530	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4F37_RS28555	COG2081	HI0933 family
E4F37_RS28610	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4F37_RS28615	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4F37_RS28660	COG3038	cytochrome b561
E4F37_RS28670	COG4774	siderophore transport
E4F37_RS28675	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E4F37_RS28690	COG3842	ATPase activity
E4F37_RS28700	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F37_RS28705	COG1177	transmembrane transport
E4F37_RS28765	COG2831	hemolysin activation secretion protein
E4F37_RS28770	COG3064	Membrane
E4F37_RS28770	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
E4F37_RS28770	COG3210	domain, Protein
E4F37_RS28775	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E4F37_RS28800	COG2188	Transcriptional regulator
E4F37_RS28810	COG2009	succinate dehydrogenase
E4F37_RS28820	COG1053	succinate dehydrogenase
E4F37_RS28825	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4F37_RS28830	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E4F37_RS28835	COG0372	Belongs to the citrate synthase family
E4F37_RS28865	COG1522	sequence-specific DNA binding
E4F37_RS28890	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4F37_RS28945	COG0135	phosphoribosylanthranilate isomerase activity
E4F37_RS28950	COG0133	tryptophan synthase activity
E4F37_RS28960	COG0159	tryptophan synthase activity
E4F37_RS28965	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4F37_RS28970	COG0285	dihydrofolate synthase activity
E4F37_RS29005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4F37_RS29010	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E4F37_RS29015	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4F37_RS29015	COG2755	lipolytic protein G-D-S-L family
E4F37_RS29035	COG0438	transferase activity, transferring glycosyl groups
E4F37_RS29050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4F37_RS29060	COG2755	lipolytic protein G-D-S-L family
E4F37_RS29060	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4F37_RS29085	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS29090	COG1295	ribonuclease BN
E4F37_RS29120	COG3608	succinylglutamate desuccinylase aspartoacylase
E4F37_RS29140	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F37_RS29150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4F37_RS29155	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4F37_RS29160	COG1126	abc transporter atp-binding protein
E4F37_RS29170	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F37_RS29195	COG0437	4 iron, 4 sulfur cluster binding
E4F37_RS29200	COG2864	formate dehydrogenase
E4F37_RS29210	COG1921	L-seryl-tRNASec selenium transferase activity
E4F37_RS29215	COG3276	selenocysteine insertion sequence binding
E4F37_RS29235	COG0154	amidase activity
E4F37_RS29245	COG1472	Belongs to the glycosyl hydrolase 3 family
E4F37_RS29290	COG3621	Patatin-like phospholipase
E4F37_RS29330	COG4191	Histidine kinase
E4F37_RS29340	COG2814	Major facilitator Superfamily
E4F37_RS29360	COG0583	DNA-binding transcription factor activity
E4F37_RS29370	COG2030	dehydratase
E4F37_RS29375	COG0427	acetyl-CoA hydrolase
E4F37_RS29380	COG0028	Belongs to the TPP enzyme family
E4F37_RS29480	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4F37_RS29485	COG4789	Type iii secretion
E4F37_RS29500	COG4790	Type iii secretion
E4F37_RS29505	COG4794	Type iii secretion
E4F37_RS29540	COG2207	Transcriptional regulator
E4F37_RS29590	COG1450	Type ii and iii secretion system protein
E4F37_RS29715	COG3550	peptidyl-serine autophosphorylation
E4F37_RS29730	COG1215	transferase activity, transferring glycosyl groups
E4F37_RS29735	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
E4F37_RS29740	COG0457	Tetratricopeptide repeat
E4F37_RS29760	COG1215	transferase activity, transferring glycosyl groups
E4F37_RS29765	COG2194	sulfuric ester hydrolase activity
E4F37_RS29775	COG2175	clavaminate synthase activity
E4F37_RS29785	COG4521	taurine ABC transporter
E4F37_RS29795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4F37_RS29825	COG0318	PFAM AMP-dependent synthetase and ligase
E4F37_RS29845	COG0306	phosphate transporter
E4F37_RS29860	COG1522	sequence-specific DNA binding
E4F37_RS29865	COG1280	lysine exporter protein (LysE YggA)
E4F37_RS29900	COG0477	Major facilitator Superfamily
E4F37_RS30050	COG4790	Type iii secretion
E4F37_RS30085	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4F37_RS30100	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4F37_RS30185	COG0302	gtp cyclohydrolase
E4F37_RS30320	COG5295	Hep Hag repeat protein
E4F37_RS30330	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4F37_RS30365	COG5564	TIM-barrel signal transduction protein
E4F37_RS30370	COG5441	Belongs to the UPF0261 family
E4F37_RS30410	COG1063	alcohol dehydrogenase
E4F37_RS30415	COG4948	Mandelate Racemase Muconate Lactonizing
E4F37_RS30425	COG0246	Mannitol dehydrogenase
E4F37_RS30435	COG2271	Major facilitator Superfamily
E4F37_RS30445	COG1349	DNA-binding transcription factor activity
E4F37_RS30470	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4F37_RS30485	COG0583	DNA-binding transcription factor activity
E4F37_RS30500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F37_RS30505	COG1012	belongs to the aldehyde dehydrogenase family
E4F37_RS30510	COG1477	protein flavinylation
E4F37_RS30560	COG2271	Major facilitator Superfamily
E4F37_RS30600	COG4638	Rieske (2fe-2S)
E4F37_RS30650	COG1960	acyl-CoA dehydrogenase activity
E4F37_RS30655	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4F37_RS30695	COG5295	Hep Hag repeat protein
E4F37_RS30695	COG5295	Hep Hag repeat protein
E4F37_RS30720	COG0798	PFAM Bile acid sodium symporter
E4F37_RS30735	COG0640	Transcriptional regulator
E4F37_RS30770	COG4175	Glycine betaine
E4F37_RS30820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4F37_RS30825	COG3622	Belongs to the hyi family
E4F37_RS30830	COG2271	Major facilitator Superfamily
E4F37_RS30835	COG0235	Class ii aldolase
E4F37_RS30840	COG3395	kinase activity
E4F37_RS30845	COG2084	Dehydrogenase
E4F37_RS30850	COG2186	Transcriptional regulator
E4F37_RS30930	COG4789	Type iii secretion
E4F37_RS30935	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4F37_RS30980	COG2207	Transcriptional regulator
E4F37_RS30985	COG1450	Type ii and iii secretion system protein
E4F37_RS31020	COG4644	lycopene metabolic process
E4F37_RS31030	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4F37_RS31060	COG1285	pathogenesis
E4F37_RS31075	COG1271	oxidase subunit
E4F37_RS31080	COG1294	oxidase, subunit
E4F37_RS31120	COG1760	l-serine dehydratase
E4F37_RS31140	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4F37_RS31140	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4F37_RS31180	COG1278	Cold shock
E4F37_RS31210	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4F37_RS31225	COG4251	negative regulation of phosphorylation
E4F37_RS31230	COG0784	Response regulator, receiver
E4F37_RS31240	COG0477	Major facilitator Superfamily
E4F37_RS31295	COG2814	Major facilitator Superfamily
E4F37_RS31320	COG1566	PFAM secretion protein HlyD family protein
E4F37_RS31330	COG1505	serine-type exopeptidase activity
E4F37_RS31345	COG1045	serine acetyltransferase
E4F37_RS31355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4F37_RS31360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4F37_RS31365	COG3038	cytochrome b561
E4F37_RS31375	COG0640	Transcriptional regulator
E4F37_RS31380	COG2391	methyltransferase activity
E4F37_RS31390	COG0456	acetyltransferase
E4F37_RS31390	COG0454	-acetyltransferase
E4F37_RS31415	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E4F37_RS31420	COG1858	cytochrome C peroxidase
E4F37_RS31435	COG2814	Major facilitator Superfamily
E4F37_RS31440	COG2188	Transcriptional regulator
E4F37_RS31495	COG0277	FAD linked oxidase domain protein
E4F37_RS31500	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4F37_RS31510	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4F37_RS31555	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4F37_RS31565	COG1446	asparaginase
E4F37_RS31570	COG4172	Belongs to the ABC transporter superfamily
E4F37_RS31580	COG0747	negative chemotaxis
E4F37_RS31585	COG0601	transmembrane transport
E4F37_RS31590	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4F37_RS31605	COG3485	protocatechuate 3,4-dioxygenase
E4F37_RS31610	COG3485	protocatechuate 3,4-dioxygenase
E4F37_RS31615	COG0583	DNA-binding transcription factor activity
E4F37_RS31635	COG4251	negative regulation of phosphorylation
E4F37_RS31635	COG3706	GGDEF domain
E4F37_RS31635	COG2203	Gaf domain
E4F37_RS31635	COG5001	Diguanylate cyclase
E4F37_RS31645	COG4122	O-methyltransferase activity
E4F37_RS31650	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4F37_RS31670	COG0531	amino acid
E4F37_RS31680	COG1201	RNA secondary structure unwinding
E4F37_RS31730	COG2274	protein secretion by the type I secretion system
E4F37_RS31770	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4F37_RS31800	COG1739	Uncharacterized protein family UPF0029
E4F37_RS31835	COG0318	PFAM AMP-dependent synthetase and ligase
E4F37_RS31875	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F37_RS31940	COG1979	alcohol dehydrogenase
E4F37_RS31945	COG2130	NADP-dependent
E4F37_RS31980	COG0583	DNA-binding transcription factor activity
E4F37_RS31995	COG0583	DNA-binding transcription factor activity
E4F37_RS32000	COG0477	Major facilitator Superfamily
E4F37_RS32040	COG0302	gtp cyclohydrolase
E4F37_RS32050	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4F37_RS32050	COG1116	anion transmembrane transporter activity
E4F37_RS32055	COG3707	response regulator
E4F37_RS32075	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4F37_RS32080	COG2146	nitrite reductase [NAD(P)H] activity
E4F37_RS32085	COG0243	molybdopterin cofactor binding
E4F37_RS32110	COG1070	Carbohydrate kinase
E4F37_RS32120	COG3842	ATPase activity
E4F37_RS32125	COG1063	alcohol dehydrogenase
E4F37_RS32170	COG2223	nitrite transmembrane transporter activity
E4F37_RS32175	COG1349	DNA-binding transcription factor activity
E4F37_RS32230	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4F37_RS32230	COG4651	solute:proton antiporter activity
E4F37_RS32235	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS32265	COG0840	transmembrane signaling receptor activity
E4F37_RS32285	COG0352	thiamine-phosphate diphosphorylase activity
E4F37_RS32290	COG0477	Major facilitator Superfamily
E4F37_RS32370	COG0540	Belongs to the ATCase OTCase family
E4F37_RS32390	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4F37_RS32450	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4F37_RS32455	COG0318	PFAM AMP-dependent synthetase and ligase
E4F37_RS32515	COG0475	glutathione-regulated potassium exporter activity
E4F37_RS32535	COG0339	signal peptide processing
E4F37_RS32540	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F37_RS32565	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E4F37_RS32585	COG2175	clavaminate synthase activity
E4F37_RS32610	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4F37_RS32635	COG3851	Histidine kinase
E4F37_RS32645	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E4F37_RS32650	COG1140	nitrate reductase beta subunit
E4F37_RS32655	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E4F37_RS32660	COG2181	nitrate reductase activity
E4F37_RS32665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4F37_RS32705	COG0651	ATP synthesis coupled electron transport
E4F37_RS32710	COG0650	Formate hydrogenlyase subunit 4
E4F37_RS32720	COG0651	ATP synthesis coupled electron transport
E4F37_RS32725	COG0649	NAD binding
E4F37_RS32730	COG3260	NADH ubiquinone oxidoreductase 20
E4F37_RS32780	COG1695	Transcriptional regulator
E4F37_RS32785	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4F37_RS32785	COG1902	pentaerythritol trinitrate reductase activity
E4F37_RS32830	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4F37_RS32830	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4F37_RS32835	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4F37_RS32850	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4F37_RS32865	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F37_RS32870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4F37_RS32930	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4F37_RS32975	COG2264	protein methyltransferase activity
E4F37_RS33025	COG0443	Heat shock 70 kDa protein
E4F37_RS33030	COG0443	Heat shock 70 kDa protein
E4F37_RS33070	COG0686	Belongs to the AlaDH PNT family
E4F37_RS33160	COG2271	Major facilitator Superfamily
E4F37_RS33170	COG1960	acyl-CoA dehydrogenase activity
E4F37_RS33205	COG1129	ABC transporter
E4F37_RS33210	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F37_RS33215	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F37_RS33220	COG4774	siderophore transport
E4F37_RS33225	COG3712	iron ion homeostasis
E4F37_RS33230	COG1595	DNA-templated transcription, initiation
E4F37_RS33275	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4F37_RS33320	COG2842	Transposition protein
E4F37_RS33350	COG0776	regulation of translation
E4F37_RS33420	COG4386	tail sheath protein
E4F37_RS33495	COG2353	YceI-like domain
E4F37_RS33525	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4F37_RS33550	COG0387	Pfam Sodium calcium exchanger
E4F37_RS33560	COG0583	DNA-binding transcription factor activity
E4F37_RS33600	COG4221	oxidoreductase activity
E4F37_RS33600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4F37_RS33600	COG3321	synthase
E4F37_RS33600	COG0300	oxidoreductase activity
E4F37_RS33605	COG3321	synthase
E4F37_RS33605	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F37_RS33605	COG0318	PFAM AMP-dependent synthetase and ligase
E4F37_RS33605	COG0300	oxidoreductase activity
E4F37_RS33605	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS33610	COG3321	synthase
E4F37_RS33610	COG4221	oxidoreductase activity
E4F37_RS33610	COG0300	oxidoreductase activity
E4F37_RS33610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4F37_RS33610	COG3321	synthase
E4F37_RS33610	COG4221	oxidoreductase activity
E4F37_RS33610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4F37_RS33610	COG0300	oxidoreductase activity
E4F37_RS33615	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS33615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F37_RS33615	COG4221	oxidoreductase activity
E4F37_RS33615	COG3321	synthase
E4F37_RS33625	COG0475	glutathione-regulated potassium exporter activity
E4F37_RS33625	COG0569	domain protein
E4F37_RS33630	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E4F37_RS33630	COG2070	2-Nitropropane dioxygenase
E4F37_RS33640	COG3547	Transposase (IS116 IS110 IS902 family)
E4F37_RS33660	COG3425	synthase
E4F37_RS33665	COG1024	Enoyl-CoA hydratase
E4F37_RS33670	COG1024	Enoyl-CoA hydratase
E4F37_RS33675	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4F37_RS33680	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4F37_RS33700	COG2207	Transcriptional regulator
E4F37_RS33705	COG0500	methyltransferase
E4F37_RS33730	COG3275	phosphorelay sensor kinase activity
E4F37_RS33785	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4F37_RS33795	COG4160	amino acid transport
E4F37_RS33820	COG2259	Doxx family
E4F37_RS33845	COG1404	Belongs to the peptidase S8 family
E4F37_RS33870	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F37_RS33875	COG0243	molybdopterin cofactor binding
E4F37_RS33880	COG3781	membrane
E4F37_RS33885	COG4682	membrane
E4F37_RS33895	COG1914	H( )-stimulated, divalent metal cation uptake system
E4F37_RS33900	COG2140	Oxalate decarboxylase
E4F37_RS33945	COG3209	COG3209 Rhs family protein
E4F37_RS33980	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
E4F37_RS33990	COG0601	transmembrane transport
E4F37_RS33995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4F37_RS34020	COG0583	DNA-binding transcription factor activity
E4F37_RS34055	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS34100	COG0596	Alpha beta hydrolase
E4F37_RS34105	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4F37_RS34125	COG0840	transmembrane signaling receptor activity
E4F37_RS34150	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4F37_RS34180	COG0596	Alpha beta hydrolase
E4F37_RS34260	COG1522	sequence-specific DNA binding
E4F37_RS34270	COG0154	amidase activity
E4F37_RS34300	COG0477	Major facilitator Superfamily
E4F37_RS34315	COG1012	belongs to the aldehyde dehydrogenase family
E4F37_RS34325	COG0028	Belongs to the TPP enzyme family
E4F37_RS34330	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS34335	COG1414	Transcriptional regulator
E4F37_RS34365	COG2146	nitrite reductase [NAD(P)H] activity
E4F37_RS34375	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS34380	COG1414	Transcriptional regulator
E4F37_RS34395	COG1408	metallophosphoesterase
E4F37_RS34405	COG1285	pathogenesis
E4F37_RS34410	COG2197	response regulator
E4F37_RS34435	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4F37_RS34440	COG0517	IMP dehydrogenase activity
E4F37_RS34440	COG0516	GMP reductase activity
E4F37_RS34455	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4F37_RS34460	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS34480	COG1902	pentaerythritol trinitrate reductase activity
E4F37_RS34500	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS34515	COG0531	amino acid
E4F37_RS34520	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4F37_RS34525	COG1012	belongs to the aldehyde dehydrogenase family
E4F37_RS34560	COG0583	DNA-binding transcription factor activity
E4F37_RS34570	COG0583	DNA-binding transcription factor activity
E4F37_RS34615	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4F37_RS34670	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4F37_RS34685	COG1113	amino acid transport
E4F37_RS34700	COG4221	oxidoreductase activity
E4F37_RS34740	COG0589	response to stress
E4F37_RS34815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4F37_RS34830	COG3291	Pkd domain containing protein
E4F37_RS34850	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4F37_RS34855	COG2175	clavaminate synthase activity
E4F37_RS34870	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E4F37_RS34875	COG0495	leucyl-tRNA aminoacylation
E4F37_RS34905	COG2373	Large extracellular alpha-helical protein
E4F37_RS34915	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4F37_RS34925	COG2201	protein-glutamate methylesterase activity
E4F37_RS34930	COG4191	Histidine kinase
E4F37_RS34930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F37_RS34985	COG1448	Aminotransferase
E4F37_RS35000	COG1522	sequence-specific DNA binding
E4F37_RS35020	COG1272	protein, Hemolysin III
E4F37_RS35075	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4F37_RS35085	COG5295	Hep Hag repeat protein
E4F37_RS35085	COG5295	Hep Hag repeat protein
E4F37_RS35110	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS35120	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS35135	COG2721	sulfolactate sulfo-lyase activity
E4F37_RS35145	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F37_RS35150	COG1129	ABC transporter
E4F37_RS35175	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS35190	COG2814	Major facilitator Superfamily
E4F37_RS35195	COG3320	Male sterility
E4F37_RS35195	COG1022	Amp-dependent synthetase and ligase
E4F37_RS35200	COG1012	belongs to the aldehyde dehydrogenase family
E4F37_RS35205	COG1024	Enoyl-CoA hydratase
E4F37_RS35280	COG2197	response regulator
E4F37_RS35300	COG3511	phospholipase C
E4F37_RS35305	COG1858	cytochrome C peroxidase
E4F37_RS35350	COG0402	S-adenosylhomocysteine deaminase activity
E4F37_RS35355	COG2508	Transcriptional regulator
E4F37_RS35360	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4F37_RS35375	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS35400	COG0583	DNA-binding transcription factor activity
E4F37_RS35445	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS35550	COG1215	transferase activity, transferring glycosyl groups
E4F37_RS35560	COG0840	transmembrane signaling receptor activity
E4F37_RS35570	COG0318	PFAM AMP-dependent synthetase and ligase
E4F37_RS35605	COG1028	Short-chain dehydrogenase reductase Sdr
E4F37_RS35615	COG0628	permease
E4F37_RS35630	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4F37_RS35645	COG1902	pentaerythritol trinitrate reductase activity
E4F37_RS35665	COG1309	transcriptional regulator
E4F37_RS35700	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
E4F37_RS35705	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4F37_RS35730	COG1024	Enoyl-CoA hydratase
E4F37_RS35750	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F37_RS35760	COG0633	Ferredoxin
E4F37_RS35760	COG3217	Mosc domain protein beta barrel domain protein
E4F37_RS35770	COG0642	Histidine kinase
E4F37_RS35785	COG4208	sulfate ABC transporter
E4F37_RS35790	COG3842	ATPase activity
E4F37_RS35805	COG2207	Transcriptional regulator
E4F37_RS35815	COG3971	2-oxopent-4-enoate hydratase activity
E4F37_RS35825	COG3384	dioxygenase
E4F37_RS35830	COG1012	belongs to the aldehyde dehydrogenase family
E4F37_RS35845	COG1846	Transcriptional regulator
E4F37_RS35860	COG0745	RESPONSE REGULATOR receiver
E4F37_RS35865	COG2205	protein histidine kinase activity
E4F37_RS35915	COG2207	Transcriptional regulator
E4F37_RS35975	COG1845	cytochrome c oxidase, subunit III
E4F37_RS35995	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E4F37_RS36005	COG0477	Major facilitator Superfamily
E4F37_RS36015	COG3214	Protein conserved in bacteria
E4F37_RS36035	COG3291	Pkd domain containing protein
E4F37_RS36185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4F37_RS36215	COG0642	Histidine kinase
E4F37_RS36300	COG2205	protein histidine kinase activity
E4F37_RS36305	COG0745	RESPONSE REGULATOR receiver
E4F37_RS36315	COG2066	Belongs to the glutaminase family
E4F37_RS36345	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4F37_RS36355	COG1538	Outer membrane efflux protein
E4F37_RS36365	COG1024	Enoyl-CoA hydratase
E4F37_RS36370	COG1024	Enoyl-CoA hydratase
E4F37_RS36385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4F37_RS36390	COG1960	acyl-CoA dehydrogenase activity
E4F37_RS36405	COG0330	HflC and HflK could
E4F37_RS36440	COG0028	Belongs to the TPP enzyme family
E4F37_RS36440	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E4F37_RS36450	COG1012	belongs to the aldehyde dehydrogenase family
E4F37_RS36495	COG2252	PERMEase
E4F37_RS36520	COG3284	Transcriptional regulator
E4F37_RS36560	COG1132	(ABC) transporter
E4F37_RS36580	COG3547	Transposase (IS116 IS110 IS902 family)
E4F37_RS36590	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F37_RS36590	COG3433	isochorismatase activity
E4F37_RS36590	COG2226	methyltransferase
E4F37_RS36600	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4F37_RS36695	COG0657	acetylesterase activity
E4F37_RS36705	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4F37_RS36710	COG3246	L-lysine catabolic process to acetate
E4F37_RS36750	COG3119	arylsulfatase activity
E4F37_RS36755	COG0583	DNA-binding transcription factor activity
E4F37_RS36770	COG2113	Glycine betaine
E4F37_RS36790	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E4F37_RS36795	COG2181	nitrate reductase activity
E4F37_RS36795	COG0247	lactate metabolic process
E4F37_RS36800	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4F37_RS36800	COG1902	pentaerythritol trinitrate reductase activity