locus-tag	class	description
E4F39_RS00020	COG2226	methyltransferase
E4F39_RS00030	COG1960	acyl-CoA dehydrogenase activity
E4F39_RS00040	COG0318	PFAM AMP-dependent synthetase and ligase
E4F39_RS00085	COG0583	DNA-binding transcription factor activity
E4F39_RS00095	COG2188	Transcriptional regulator
E4F39_RS00100	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
E4F39_RS00105	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4F39_RS00110	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4F39_RS00110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4F39_RS00115	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
E4F39_RS00115	COG1263	PTS System
E4F39_RS00115	COG2190	(PTS) system
E4F39_RS00150	COG1294	oxidase, subunit
E4F39_RS00165	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4F39_RS00175	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
E4F39_RS00185	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E4F39_RS00200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E4F39_RS00205	COG0243	molybdopterin cofactor binding
E4F39_RS00215	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4F39_RS00225	COG0625	glutathione transferase activity
E4F39_RS00235	COG0742	ribosomal rna small subunit methyltransferase
E4F39_RS00250	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E4F39_RS00260	COG0193	aminoacyl-tRNA hydrolase activity
E4F39_RS00270	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E4F39_RS00285	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
E4F39_RS00300	COG1194	a g-specific adenine glycosylase
E4F39_RS00325	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
E4F39_RS00335	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4F39_RS00340	COG1137	ATPase activity
E4F39_RS00355	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4F39_RS00380	COG1280	lysine exporter protein (LysE YggA)
E4F39_RS00415	COG2814	Major facilitator Superfamily
E4F39_RS00420	COG0629	single-stranded DNA binding
E4F39_RS00535	COG0235	Class ii aldolase
E4F39_RS00550	COG5002	protein histidine kinase activity
E4F39_RS00550	COG5001	Diguanylate cyclase
E4F39_RS00595	COG2204	response regulator
E4F39_RS00615	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E4F39_RS00625	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4F39_RS00645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4F39_RS00650	COG1596	polysaccharide export
E4F39_RS00695	COG0477	Major facilitator Superfamily
E4F39_RS00720	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
E4F39_RS00725	COG0251	oxidation-reduction process
E4F39_RS00735	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4F39_RS00810	COG0494	nUDIX hydrolase
E4F39_RS00825	COG1960	acyl-CoA dehydrogenase activity
E4F39_RS00830	COG1024	Enoyl-CoA hydratase
E4F39_RS00830	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4F39_RS00835	COG0183	Belongs to the thiolase family
E4F39_RS00840	COG1024	Enoyl-CoA hydratase
E4F39_RS00845	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E4F39_RS00865	COG5265	(ABC) transporter
E4F39_RS00875	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E4F39_RS00880	COG3178	'Phosphotransferase
E4F39_RS00925	COG0204	Acyl-transferase
E4F39_RS00930	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4F39_RS00935	COG0751	glycine-tRNA ligase activity
E4F39_RS00940	COG0752	glycyl-tRNA synthetase alpha subunit
E4F39_RS00945	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E4F39_RS00955	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
E4F39_RS00970	COG1702	phosphate starvation-inducible protein PhoH
E4F39_RS00985	COG0583	DNA-binding transcription factor activity
E4F39_RS00990	COG2814	Major facilitator Superfamily
E4F39_RS00995	COG1396	sequence-specific DNA binding
E4F39_RS01005	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4F39_RS01020	COG0367	asparagine synthase
E4F39_RS01025	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4F39_RS01030	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4F39_RS01045	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4F39_RS01050	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4F39_RS01095	COG0513	Belongs to the DEAD box helicase family
E4F39_RS01125	COG4948	Mandelate Racemase Muconate Lactonizing
E4F39_RS01190	COG1301	dicarboxylic acid transport
E4F39_RS01195	COG0583	DNA-binding transcription factor activity
E4F39_RS01200	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E4F39_RS01285	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4F39_RS01290	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
E4F39_RS01295	COG0028	Belongs to the TPP enzyme family
E4F39_RS01335	COG0583	DNA-binding transcription factor activity
E4F39_RS01340	COG5002	protein histidine kinase activity
E4F39_RS01340	COG0784	Response regulator, receiver
E4F39_RS01395	COG0583	DNA-binding transcription factor activity
E4F39_RS01425	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4F39_RS01455	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E4F39_RS01460	COG2137	regulation of response to DNA damage stimulus
E4F39_RS01475	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E4F39_RS01480	COG0861	Integral membrane protein TerC family
E4F39_RS01485	COG4969	Belongs to the N-Me-Phe pilin family
E4F39_RS01490	COG3307	-O-antigen
E4F39_RS01525	COG4783	chaperone-mediated protein folding
E4F39_RS01535	COG0429	hydrolase of the alpha beta-hydrolase fold
E4F39_RS01545	COG0859	PFAM glycosyl transferase family 9
E4F39_RS01570	COG0126	phosphoglycerate kinase activity
E4F39_RS01580	COG0469	pyruvate kinase activity
E4F39_RS01590	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E4F39_RS01595	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E4F39_RS01600	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
E4F39_RS01605	COG0009	L-threonylcarbamoyladenylate synthase
E4F39_RS01650	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4F39_RS01680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4F39_RS01685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F39_RS01700	COG2233	PERMEase
E4F39_RS01705	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4F39_RS01720	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
E4F39_RS01725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E4F39_RS01730	COG1121	(ABC) transporter
E4F39_RS01740	COG0735	belongs to the Fur family
E4F39_RS01750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4F39_RS01765	COG1175	transmembrane transport
E4F39_RS01775	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4F39_RS01780	COG3842	ATPase activity
E4F39_RS01795	COG0583	DNA-binding transcription factor activity
E4F39_RS01810	COG2390	Transcriptional regulator
E4F39_RS01815	COG1070	Carbohydrate kinase
E4F39_RS01820	COG0246	Mannitol dehydrogenase
E4F39_RS01825	COG0583	DNA-binding transcription factor activity
E4F39_RS01835	COG1012	belongs to the aldehyde dehydrogenase family
E4F39_RS01840	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
E4F39_RS01850	COG2271	Major facilitator Superfamily
E4F39_RS01870	COG1522	sequence-specific DNA binding
E4F39_RS01875	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4F39_RS01885	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E4F39_RS01895	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4F39_RS01905	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
E4F39_RS01915	COG3118	belongs to the thioredoxin family
E4F39_RS01920	COG1741	Belongs to the pirin family
E4F39_RS01935	COG0860	N-Acetylmuramoyl-L-alanine amidase
E4F39_RS01940	COG0802	atpase or kinase
E4F39_RS01945	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E4F39_RS01955	COG4974	Belongs to the 'phage' integrase family
E4F39_RS01960	COG0318	PFAM AMP-dependent synthetase and ligase
E4F39_RS01965	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
E4F39_RS01985	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4F39_RS02005	COG0728	peptidoglycan biosynthetic process
E4F39_RS02045	COG1663	tetraacyldisaccharide 4'-kinase activity
E4F39_RS02055	COG1570	exodeoxyribonuclease VII activity
E4F39_RS02060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E4F39_RS02130	COG2814	Major facilitator Superfamily
E4F39_RS02150	COG2188	Transcriptional regulator
E4F39_RS02155	COG0656	L-ascorbic acid biosynthetic process
E4F39_RS02190	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
E4F39_RS02230	COG1278	Cold shock
E4F39_RS02240	COG0542	response to heat
E4F39_RS02245	COG1113	amino acid transport
E4F39_RS02275	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4F39_RS02280	COG0196	riboflavin kinase activity
E4F39_RS02285	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4F39_RS02290	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4F39_RS02290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4F39_RS02295	COG1511	domain protein
E4F39_RS02295	COG3264	Mechanosensitive ion channel
E4F39_RS02320	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
E4F39_RS02340	COG1047	Peptidyl-prolyl cis-trans
E4F39_RS02345	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E4F39_RS02385	COG0456	acetyltransferase
E4F39_RS02390	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4F39_RS02395	COG0543	2 iron, 2 sulfur cluster binding
E4F39_RS02395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4F39_RS02410	COG1187	pseudouridine synthase activity
E4F39_RS02420	COG0583	DNA-binding transcription factor activity
E4F39_RS02430	COG2267	carboxylic ester hydrolase activity
E4F39_RS02435	COG2258	MOSC domain
E4F39_RS02440	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4F39_RS02450	COG1396	sequence-specific DNA binding
E4F39_RS02465	COG0583	DNA-binding transcription factor activity
E4F39_RS02480	COG0175	sulfate reduction
E4F39_RS02490	COG2895	sulfate adenylyltransferase (ATP) activity
E4F39_RS02495	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
E4F39_RS02495	COG1648	precorrin-2 dehydrogenase activity
E4F39_RS02510	COG0795	lipopolysaccharide-transporting ATPase activity
E4F39_RS02530	COG4654	Cytochrome c, class I
E4F39_RS02545	COG0583	DNA-binding transcription factor activity
E4F39_RS02590	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E4F39_RS02595	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
E4F39_RS02600	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
E4F39_RS02620	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E4F39_RS02630	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E4F39_RS02640	COG1492	cobalamin metabolic process
E4F39_RS02645	COG2259	Doxx family
E4F39_RS02650	COG0489	protein tyrosine kinase activity
E4F39_RS02670	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
E4F39_RS02680	COG0729	surface antigen
E4F39_RS02685	COG2911	Protein conserved in bacteria
E4F39_RS02715	COG2885	chlorophyll binding
E4F39_RS02715	COG3047	cAMP biosynthetic process
E4F39_RS02725	COG0489	protein tyrosine kinase activity
E4F39_RS02750	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E4F39_RS02790	COG2226	methyltransferase
E4F39_RS02825	COG2271	Major facilitator Superfamily
E4F39_RS02840	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E4F39_RS02845	COG2827	Endonuclease containing a URI domain
E4F39_RS02875	COG0347	Belongs to the P(II) protein family
E4F39_RS02895	COG4215	(ABC) transporter
E4F39_RS02910	COG1741	Belongs to the pirin family
E4F39_RS02945	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F39_RS02950	COG1116	anion transmembrane transporter activity
E4F39_RS02980	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E4F39_RS03000	COG2814	Major facilitator Superfamily
E4F39_RS03005	COG1881	PFAM PEBP family protein
E4F39_RS03180	COG1773	rubredoxin
E4F39_RS03190	COG0488	(ABC) transporter
E4F39_RS03220	COG0583	DNA-binding transcription factor activity
E4F39_RS03235	COG0583	DNA-binding transcription factor activity
E4F39_RS03245	COG0477	Major facilitator Superfamily
E4F39_RS03290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F39_RS03295	COG0697	spore germination
E4F39_RS03305	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F39_RS03330	COG4106	trans-aconitate 2-methyltransferase activity
E4F39_RS03345	COG2764	glyoxalase bleomycin resistance protein dioxygenase
E4F39_RS03360	COG3135	benzoate transporter
E4F39_RS03400	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E4F39_RS03405	COG2878	Part of a membrane complex involved in electron transport
E4F39_RS03410	COG1309	transcriptional regulator
E4F39_RS03420	COG3387	PFAM Glycoside hydrolase 15-related
E4F39_RS03430	COG2706	6-phosphogluconolactonase activity
E4F39_RS03470	COG0513	Belongs to the DEAD box helicase family
E4F39_RS03480	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4F39_RS03520	COG0438	transferase activity, transferring glycosyl groups
E4F39_RS03525	COG0859	PFAM glycosyl transferase family 9
E4F39_RS03565	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4F39_RS03575	COG1595	DNA-templated transcription, initiation
E4F39_RS03630	COG2233	PERMEase
E4F39_RS03655	COG0799	negative regulation of ribosome biogenesis
E4F39_RS03670	COG0151	Belongs to the GarS family
E4F39_RS03690	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS03725	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
E4F39_RS03730	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E4F39_RS03745	COG2205	protein histidine kinase activity
E4F39_RS03750	COG0745	RESPONSE REGULATOR receiver
E4F39_RS03785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4F39_RS03795	COG0154	amidase activity
E4F39_RS03805	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4F39_RS03835	COG0438	transferase activity, transferring glycosyl groups
E4F39_RS03870	COG0028	Belongs to the TPP enzyme family
E4F39_RS03890	COG1183	phosphatidylcholine synthase activity
E4F39_RS03900	COG0659	secondary active sulfate transmembrane transporter activity
E4F39_RS03905	COG0288	reversible hydration of carbon dioxide
E4F39_RS03920	COG0683	leucine binding
E4F39_RS03940	COG0604	alcohol dehydrogenase
E4F39_RS03940	COG4221	oxidoreductase activity
E4F39_RS03940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F39_RS03940	COG3321	synthase
E4F39_RS03945	COG0149	triose-phosphate isomerase activity
E4F39_RS03980	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
E4F39_RS03990	COG1034	ATP synthesis coupled electron transport
E4F39_RS04025	COG1007	ATP synthesis coupled electron transport
E4F39_RS04045	COG1960	acyl-CoA dehydrogenase activity
E4F39_RS04050	COG1960	acyl-CoA dehydrogenase activity
E4F39_RS04055	COG2030	dehydratase
E4F39_RS04055	COG1012	belongs to the aldehyde dehydrogenase family
E4F39_RS04075	COG1960	acyl-CoA dehydrogenase activity
E4F39_RS04085	COG0588	phosphoglycerate mutase activity
E4F39_RS04090	COG1024	Enoyl-CoA hydratase
E4F39_RS04100	COG0436	Aminotransferase
E4F39_RS04115	COG2866	Carboxypeptidase
E4F39_RS04190	COG0006	proline dipeptidase activity
E4F39_RS04205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4F39_RS04225	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4F39_RS04260	COG2863	cytochrome
E4F39_RS04265	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4F39_RS04265	COG2010	Cytochrome c
E4F39_RS04280	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4F39_RS04325	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F39_RS04330	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F39_RS04385	COG1522	sequence-specific DNA binding
E4F39_RS04390	COG3842	ATPase activity
E4F39_RS04395	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F39_RS04400	COG1840	ABC-type Fe3 transport system, periplasmic component
E4F39_RS04425	COG1289	transmembrane transporter activity
E4F39_RS04435	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
E4F39_RS04440	COG1074	ATP-dependent DNA helicase activity
E4F39_RS04445	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E4F39_RS04455	COG2200	EAL domain
E4F39_RS04505	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
E4F39_RS04510	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E4F39_RS04525	COG0697	spore germination
E4F39_RS04535	COG2814	Major facilitator Superfamily
E4F39_RS04565	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
E4F39_RS04575	COG3842	ATPase activity
E4F39_RS04585	COG1177	transmembrane transport
E4F39_RS04600	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4F39_RS04605	COG1840	ABC-type Fe3 transport system, periplasmic component
E4F39_RS04610	COG1609	Transcriptional regulator
E4F39_RS04685	COG1522	sequence-specific DNA binding
E4F39_RS04715	COG0583	DNA-binding transcription factor activity
E4F39_RS04755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F39_RS04800	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
E4F39_RS04805	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4F39_RS04815	COG0583	DNA-binding transcription factor activity
E4F39_RS04840	COG3052	prosthetic group binding
E4F39_RS04875	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4F39_RS04920	COG0477	Major facilitator Superfamily
E4F39_RS04940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
E4F39_RS04945	COG0328	RNA-DNA hybrid ribonuclease activity
E4F39_RS04950	COG2226	methyltransferase
E4F39_RS04955	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4F39_RS04960	COG0741	lytic transglycosylase activity
E4F39_RS04960	COG1388	LysM domain
E4F39_RS04990	COG0505	Belongs to the CarA family
E4F39_RS05000	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E4F39_RS05005	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4F39_RS05015	COG1534	Rna-binding protein
E4F39_RS05025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E4F39_RS05030	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E4F39_RS05045	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E4F39_RS05050	COG0573	inorganic phosphate transmembrane transporter activity
E4F39_RS05055	COG0581	inorganic phosphate transmembrane transporter activity
E4F39_RS05070	COG0745	RESPONSE REGULATOR receiver
E4F39_RS05085	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E4F39_RS05165	COG0534	Mate efflux family protein
E4F39_RS05180	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4F39_RS05185	COG4942	peptidase
E4F39_RS05250	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E4F39_RS05300	COG0366	Alpha amylase catalytic
E4F39_RS05305	COG0366	Alpha amylase catalytic
E4F39_RS05355	COG0583	DNA-binding transcription factor activity
E4F39_RS05405	COG0859	PFAM glycosyl transferase family 9
E4F39_RS05405	COG0457	Tetratricopeptide repeat
E4F39_RS05555	COG1914	H( )-stimulated, divalent metal cation uptake system
E4F39_RS05595	COG2814	Major facilitator Superfamily
E4F39_RS05605	COG0583	DNA-binding transcription factor activity
E4F39_RS05670	COG1538	Outer membrane efflux protein
E4F39_RS05675	COG2814	Major facilitator Superfamily
E4F39_RS05685	COG1566	PFAM secretion protein HlyD family protein
E4F39_RS05700	COG3511	phospholipase C
E4F39_RS05705	COG1858	cytochrome C peroxidase
E4F39_RS05730	COG0494	nUDIX hydrolase
E4F39_RS05740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E4F39_RS05755	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4F39_RS05780	COG0477	Major facilitator Superfamily
E4F39_RS05805	COG2816	NAD+ diphosphatase activity
E4F39_RS05830	COG0824	Thioesterase
E4F39_RS05850	COG3718	enzyme involved in inositol metabolism
E4F39_RS05860	COG3962	Belongs to the TPP enzyme family
E4F39_RS05875	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F39_RS05890	COG0673	inositol 2-dehydrogenase activity
E4F39_RS05895	COG0673	inositol 2-dehydrogenase activity
E4F39_RS05905	COG0425	Belongs to the sulfur carrier protein TusA family
E4F39_RS05915	COG0745	RESPONSE REGULATOR receiver
E4F39_RS05925	COG5002	protein histidine kinase activity
E4F39_RS05935	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4F39_RS05940	COG0525	valine-tRNA ligase activity
E4F39_RS05945	COG0210	DNA helicase
E4F39_RS05950	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4F39_RS05955	COG2223	nitrite transmembrane transporter activity
E4F39_RS05960	COG0840	transmembrane signaling receptor activity
E4F39_RS05995	COG0583	DNA-binding transcription factor activity
E4F39_RS06010	COG0277	FAD linked oxidase domain protein
E4F39_RS06025	COG1295	ribonuclease BN
E4F39_RS06050	COG0477	Major facilitator Superfamily
E4F39_RS06085	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS06140	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS06155	COG0583	DNA-binding transcription factor activity
E4F39_RS06165	COG2267	carboxylic ester hydrolase activity
E4F39_RS06170	COG0251	oxidation-reduction process
E4F39_RS06175	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4F39_RS06190	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E4F39_RS06215	COG0776	regulation of translation
E4F39_RS06230	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4F39_RS06230	COG2755	lipolytic protein G-D-S-L family
E4F39_RS06255	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E4F39_RS06315	COG0583	DNA-binding transcription factor activity
E4F39_RS06320	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
E4F39_RS06325	COG1187	pseudouridine synthase activity
E4F39_RS06335	COG0195	Participates in both transcription termination and antitermination
E4F39_RS06335	COG2251	uridine kinase activity
E4F39_RS06350	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E4F39_RS06360	COG2814	Major facilitator Superfamily
E4F39_RS06365	COG1566	PFAM secretion protein HlyD family protein
E4F39_RS06375	COG1846	Transcriptional regulator
E4F39_RS06385	COG1217	gtp-binding protein TYPA
E4F39_RS06390	COG0567	Dehydrogenase, E1 component
E4F39_RS06395	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4F39_RS06400	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4F39_RS06405	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
E4F39_RS06470	COG4964	Belongs to the GSP D family
E4F39_RS06540	COG0318	PFAM AMP-dependent synthetase and ligase
E4F39_RS06550	COG2814	Major facilitator Superfamily
E4F39_RS06555	COG0519	Catalyzes the synthesis of GMP from XMP
E4F39_RS06585	COG0840	transmembrane signaling receptor activity
E4F39_RS06600	COG0557	exoribonuclease II activity
E4F39_RS06605	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4F39_RS06615	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4F39_RS06625	COG1802	Transcriptional regulator
E4F39_RS06630	COG0673	inositol 2-dehydrogenase activity
E4F39_RS06635	COG0765	amino acid transport
E4F39_RS06640	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F39_RS06705	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4F39_RS06750	COG1301	dicarboxylic acid transport
E4F39_RS06780	COG0667	Aldo Keto reductase
E4F39_RS06785	COG0701	Predicted permease
E4F39_RS06835	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
E4F39_RS06840	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
E4F39_RS06845	COG4208	sulfate ABC transporter
E4F39_RS06850	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
E4F39_RS06855	COG0583	DNA-binding transcription factor activity
E4F39_RS06860	COG1879	ABC-type sugar transport system periplasmic component
E4F39_RS06870	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F39_RS06875	COG1609	Transcriptional regulator
E4F39_RS06885	COG0840	transmembrane signaling receptor activity
E4F39_RS06895	COG2766	serine protein kinase
E4F39_RS06900	COG2718	Belongs to the UPF0229 family
E4F39_RS06905	COG2719	SpoVR family
E4F39_RS06915	COG0477	Major facilitator Superfamily
E4F39_RS06930	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
E4F39_RS06935	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4F39_RS06960	COG4964	Belongs to the GSP D family
E4F39_RS07005	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F39_RS07020	COG4597	amino acid ABC transporter
E4F39_RS07030	COG0739	heme binding
E4F39_RS07040	COG1309	transcriptional regulator
E4F39_RS07050	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F39_RS07075	COG3539	Fimbrial protein
E4F39_RS07085	COG3121	Chaperone
E4F39_RS07130	COG1879	ABC-type sugar transport system periplasmic component
E4F39_RS07135	COG1129	ABC transporter
E4F39_RS07140	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F39_RS07150	COG1063	alcohol dehydrogenase
E4F39_RS07155	COG1070	Carbohydrate kinase
E4F39_RS07160	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS07250	COG4774	siderophore transport
E4F39_RS07255	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E4F39_RS07285	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
E4F39_RS07320	COG4974	Belongs to the 'phage' integrase family
E4F39_RS07335	COG4644	lycopene metabolic process
E4F39_RS07340	COG0400	carboxylic ester hydrolase activity
E4F39_RS07360	COG3979	chitinase
E4F39_RS07380	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4F39_RS07390	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
E4F39_RS07410	COG1649	PFAM Uncharacterised BCR, COG1649
E4F39_RS07415	COG2807	transmembrane transport
E4F39_RS07420	COG1846	Transcriptional regulator
E4F39_RS07440	COG0625	glutathione transferase activity
E4F39_RS07445	COG0583	DNA-binding transcription factor activity
E4F39_RS07455	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS07470	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E4F39_RS07475	COG2235	arginine
E4F39_RS07500	COG1174	glycine betaine transport
E4F39_RS07505	COG1125	glycine betaine transport
E4F39_RS07510	COG1174	glycine betaine transport
E4F39_RS07515	COG1732	Glycine betaine
E4F39_RS07565	COG0835	chemotaxis
E4F39_RS07580	COG2207	Transcriptional regulator
E4F39_RS07590	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS07610	COG3251	PFAM MbtH domain protein
E4F39_RS07620	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4F39_RS07635	COG0137	argininosuccinate synthase activity
E4F39_RS07640	COG0165	Argininosuccinate lyase
E4F39_RS07660	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4F39_RS07685	COG2192	nodulation
E4F39_RS07715	COG3220	belongs to the UPF0276 family
E4F39_RS07740	COG1595	DNA-templated transcription, initiation
E4F39_RS07765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E4F39_RS07780	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4F39_RS07790	COG2986	histidine ammonia-lyase
E4F39_RS07800	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS07835	COG0745	RESPONSE REGULATOR receiver
E4F39_RS07845	COG0529	Catalyzes the synthesis of activated sulfate
E4F39_RS07850	COG0859	PFAM glycosyl transferase family 9
E4F39_RS07850	COG0457	Tetratricopeptide repeat
E4F39_RS07860	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4F39_RS07865	COG2274	protein secretion by the type I secretion system
E4F39_RS07895	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4F39_RS07920	COG1414	Transcriptional regulator
E4F39_RS08010	COG0475	glutathione-regulated potassium exporter activity
E4F39_RS08030	COG2376	Dihydroxyacetone kinase
E4F39_RS08065	COG4263	nitrous-oxide reductase activity
E4F39_RS08080	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
E4F39_RS08115	COG1196	nuclear chromosome segregation
E4F39_RS08115	COG3264	Mechanosensitive ion channel
E4F39_RS08160	COG0598	Magnesium transport protein CorA
E4F39_RS08250	COG1609	Transcriptional regulator
E4F39_RS08260	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4F39_RS08270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4F39_RS08290	COG2855	membrane
E4F39_RS08295	COG0038	chloride channel
E4F39_RS08310	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F39_RS08315	COG1538	Outer membrane efflux protein
E4F39_RS08340	COG3655	Transcriptional regulator
E4F39_RS08365	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4F39_RS08365	COG0730	response to heat
E4F39_RS08375	COG1177	transmembrane transport
E4F39_RS08380	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F39_RS08385	COG3842	ATPase activity
E4F39_RS08390	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
E4F39_RS08395	COG1914	H( )-stimulated, divalent metal cation uptake system
E4F39_RS08410	COG3047	cAMP biosynthetic process
E4F39_RS08415	COG2070	2-Nitropropane dioxygenase
E4F39_RS08435	COG0488	(ABC) transporter
E4F39_RS08445	COG2982	Protein involved in outer membrane biogenesis
E4F39_RS08450	COG1122	ATPase activity
E4F39_RS08455	COG0390	transport system, permease component
E4F39_RS08480	COG0560	Phosphoserine phosphatase
E4F39_RS08485	COG0626	cystathionine gamma-synthase activity
E4F39_RS08495	COG0183	Belongs to the thiolase family
E4F39_RS08520	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS08525	COG0183	Belongs to the thiolase family
E4F39_RS08530	COG3243	poly(R)-hydroxyalkanoic acid synthase
E4F39_RS08540	COG0564	pseudouridine synthase activity
E4F39_RS08555	COG1199	ATP-dependent helicase activity
E4F39_RS08570	COG2183	response to ionizing radiation
E4F39_RS08580	COG3547	Transposase (IS116 IS110 IS902 family)
E4F39_RS08595	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
E4F39_RS08620	COG0330	HflC and HflK could
E4F39_RS08625	COG0330	HflC and HflK could
E4F39_RS08630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
E4F39_RS08645	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4F39_RS08680	COG0670	Belongs to the BI1 family
E4F39_RS08725	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4F39_RS08740	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E4F39_RS08765	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E4F39_RS08770	COG0789	Transcriptional regulator
E4F39_RS08775	COG0477	Major facilitator Superfamily
E4F39_RS08780	COG3228	Belongs to the MtfA family
E4F39_RS08800	COG0534	Mate efflux family protein
E4F39_RS08830	COG0542	response to heat
E4F39_RS08835	COG1959	2 iron, 2 sulfur cluster binding
E4F39_RS08840	COG2346	COG2346, Truncated hemoglobins
E4F39_RS08845	COG0314	molybdopterin synthase activity
E4F39_RS08850	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
E4F39_RS08880	COG0436	Aminotransferase
E4F39_RS08890	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
E4F39_RS08895	COG2076	Multidrug Resistance protein
E4F39_RS08900	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4F39_RS08905	COG0463	Glycosyl transferase, family 2
E4F39_RS08915	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4F39_RS08915	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E4F39_RS08920	COG0726	polysaccharide deacetylase
E4F39_RS08925	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E4F39_RS08935	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
E4F39_RS08940	COG0791	NLP P60 protein
E4F39_RS08950	COG0306	phosphate transporter
E4F39_RS08995	COG1595	DNA-templated transcription, initiation
E4F39_RS09010	COG0583	DNA-binding transcription factor activity
E4F39_RS09015	COG3960	tartronate-semialdehyde synthase activity
E4F39_RS09020	COG3622	Belongs to the hyi family
E4F39_RS09025	COG2084	Dehydrogenase
E4F39_RS09035	COG1652	LysM domain
E4F39_RS09045	COG0252	asparaginase activity
E4F39_RS09080	COG0438	transferase activity, transferring glycosyl groups
E4F39_RS09110	COG0084	hydrolase, TatD family'
E4F39_RS09115	COG1247	-acetyltransferase
E4F39_RS09130	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
E4F39_RS09135	COG0354	folic acid binding
E4F39_RS09150	COG0657	acetylesterase activity
E4F39_RS09155	COG2130	NADP-dependent
E4F39_RS09185	COG0183	Belongs to the thiolase family
E4F39_RS09190	COG1335	isochorismatase
E4F39_RS09195	COG1024	Enoyl-CoA hydratase
E4F39_RS09195	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4F39_RS09205	COG0318	PFAM AMP-dependent synthetase and ligase
E4F39_RS09230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4F39_RS09240	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E4F39_RS09240	COG0047	phosphoribosylformylglycinamidine synthase activity
E4F39_RS09250	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4F39_RS09270	COG4181	ATPase activity
E4F39_RS09350	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E4F39_RS09375	COG1929	Belongs to the glycerate kinase type-1 family
E4F39_RS09380	COG1846	Transcriptional regulator
E4F39_RS09525	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4F39_RS09540	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E4F39_RS09630	COG3360	Dodecin
E4F39_RS09640	COG0583	DNA-binding transcription factor activity
E4F39_RS09655	COG2351	hydroxyisourate hydrolase activity
E4F39_RS09675	COG4266	Belongs to the allantoicase family
E4F39_RS09680	COG3648	Uricase
E4F39_RS09680	COG3195	allantoin biosynthetic process
E4F39_RS09695	COG1953	Uracil, thiamine, allantoin
E4F39_RS09705	COG1619	proteins homologs of microcin C7 resistance protein MccF
E4F39_RS09745	COG2814	Major facilitator Superfamily
E4F39_RS09770	COG1196	nuclear chromosome segregation
E4F39_RS09845	COG0697	spore germination
E4F39_RS09855	COG2867	negative regulation of translational initiation
E4F39_RS09865	COG0330	HflC and HflK could
E4F39_RS09910	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E4F39_RS09950	COG0750	zinc metalloprotease
E4F39_RS09965	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
E4F39_RS09995	COG0024	Methionine aminopeptidase
E4F39_RS10005	COG1187	pseudouridine synthase activity
E4F39_RS10010	COG0242	peptide deformylase activity
E4F39_RS10055	COG1393	Belongs to the ArsC family
E4F39_RS10065	COG2890	protein-(glutamine-N5) methyltransferase activity
E4F39_RS10080	COG0386	Belongs to the glutathione peroxidase family
E4F39_RS10085	COG0488	(ABC) transporter
E4F39_RS10105	COG0477	Major facilitator Superfamily
E4F39_RS10110	COG0351	phosphomethylpyrimidine kinase
E4F39_RS10125	COG1573	uracil-dna glycosylase
E4F39_RS10140	COG1214	PFAM Peptidase M22, glycoprotease
E4F39_RS10150	COG0513	Belongs to the DEAD box helicase family
E4F39_RS10155	COG2224	Isocitrate lyase
E4F39_RS10165	COG0583	DNA-binding transcription factor activity
E4F39_RS10175	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
E4F39_RS10240	COG1752	Esterase of the alpha-beta hydrolase superfamily
E4F39_RS10245	COG0791	NLP P60 protein
E4F39_RS10255	COG4172	Belongs to the ABC transporter superfamily
E4F39_RS10260	COG4239	(ABC) transporter, permease
E4F39_RS10265	COG4174	ABC transporter (Permease)
E4F39_RS10270	COG4166	transmembrane transport
E4F39_RS10295	COG0243	molybdopterin cofactor binding
E4F39_RS10310	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4F39_RS10330	COG0024	Methionine aminopeptidase
E4F39_RS10350	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E4F39_RS10370	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E4F39_RS10385	COG3958	Transketolase
E4F39_RS10410	COG2175	clavaminate synthase activity
E4F39_RS10505	COG0527	aspartate kinase activity
E4F39_RS10515	COG0037	tRNA processing
E4F39_RS10540	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E4F39_RS10550	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E4F39_RS10560	COG1045	serine acetyltransferase
E4F39_RS10575	COG0483	inositol monophosphate 1-phosphatase activity
E4F39_RS10635	COG3311	Transcriptional regulator
E4F39_RS10950	COG2850	peptidyl-arginine hydroxylation
E4F39_RS10965	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4F39_RS10970	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
E4F39_RS10975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4F39_RS10985	COG0180	Tryptophanyl-tRNA synthetase
E4F39_RS10990	COG1994	Peptidase M50
E4F39_RS10995	COG0009	L-threonylcarbamoyladenylate synthase
E4F39_RS11000	COG0613	PHP domain protein
E4F39_RS11010	COG0596	Alpha beta hydrolase
E4F39_RS11020	COG2833	Protein of unknown function (DUF455)
E4F39_RS11030	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
E4F39_RS11040	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
E4F39_RS11060	COG2267	carboxylic ester hydrolase activity
E4F39_RS11065	COG0658	competence protein
E4F39_RS11065	COG2333	competence protein COMEC
E4F39_RS11070	COG0084	hydrolase, TatD family'
E4F39_RS11075	COG1136	(ABC) transporter
E4F39_RS11095	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
E4F39_RS11125	COG2975	iron-sulfur cluster assembly
E4F39_RS11145	COG0316	Belongs to the HesB IscA family
E4F39_RS11150	COG0822	iron-sulfur transferase activity
E4F39_RS11155	COG1104	cysteine desulfurase activity
E4F39_RS11165	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4F39_RS11190	COG1414	Transcriptional regulator
E4F39_RS11215	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
E4F39_RS11220	COG0508	dehydrogenase complex catalyzes the overall conversion of
E4F39_RS11225	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
E4F39_RS11235	COG4566	intracellular signal transduction
E4F39_RS11255	COG0339	signal peptide processing
E4F39_RS11260	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
E4F39_RS11285	COG2223	nitrite transmembrane transporter activity
E4F39_RS11290	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E4F39_RS11295	COG1140	nitrate reductase beta subunit
E4F39_RS11305	COG2181	nitrate reductase activity
E4F39_RS11310	COG4585	Histidine kinase
E4F39_RS11315	COG2197	response regulator
E4F39_RS11340	COG0174	glutamine synthetase
E4F39_RS11355	COG1058	Belongs to the CinA family
E4F39_RS11355	COG1546	Belongs to the CinA family
E4F39_RS11380	COG1643	Atp-dependent helicase
E4F39_RS11385	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
E4F39_RS11385	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E4F39_RS11395	COG0477	Major facilitator Superfamily
E4F39_RS11410	COG1960	acyl-CoA dehydrogenase activity
E4F39_RS11415	COG0583	DNA-binding transcription factor activity
E4F39_RS11445	COG0174	glutamine synthetase
E4F39_RS11450	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4F39_RS11490	COG0402	S-adenosylhomocysteine deaminase activity
E4F39_RS11505	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
E4F39_RS11555	COG0529	Catalyzes the synthesis of activated sulfate
E4F39_RS11560	COG0415	Belongs to the DNA photolyase family
E4F39_RS11580	COG2151	metal-sulfur cluster biosynthetic enzyme
E4F39_RS11625	COG3154	lipid carrier protein
E4F39_RS11630	COG0826	peptidase U32
E4F39_RS11635	COG0826	peptidase U32
E4F39_RS11660	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4F39_RS11665	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4F39_RS11670	COG0840	transmembrane signaling receptor activity
E4F39_RS11690	COG0719	Fe-S assembly protein
E4F39_RS11695	COG0396	ATPase activity
E4F39_RS11705	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4F39_RS11710	COG0822	iron-sulfur transferase activity
E4F39_RS11715	COG2151	metal-sulfur cluster biosynthetic enzyme
E4F39_RS11730	COG1959	2 iron, 2 sulfur cluster binding
E4F39_RS11760	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4F39_RS11770	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F39_RS11805	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E4F39_RS11825	COG4598	ABC transporter
E4F39_RS11855	COG3394	polysaccharide catabolic process
E4F39_RS11870	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4F39_RS11880	COG0596	Alpha beta hydrolase
E4F39_RS11900	COG3511	phospholipase C
E4F39_RS11910	COG0683	leucine binding
E4F39_RS11915	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4F39_RS11930	COG0438	transferase activity, transferring glycosyl groups
E4F39_RS11935	COG1132	(ABC) transporter
E4F39_RS11940	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
E4F39_RS11955	COG1999	signal sequence binding
E4F39_RS11970	COG2153	protein acetylation
E4F39_RS11985	COG0583	DNA-binding transcription factor activity
E4F39_RS11990	COG1956	GAF domain-containing protein
E4F39_RS12015	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
E4F39_RS12035	COG2204	response regulator
E4F39_RS12060	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E4F39_RS12065	COG0571	ribonuclease III activity
E4F39_RS12070	COG0681	Belongs to the peptidase S26 family
E4F39_RS12085	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4F39_RS12090	COG3026	antisigma factor binding
E4F39_RS12110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4F39_RS12150	COG1399	metal-binding, possibly nucleic acid-binding protein
E4F39_RS12175	COG0546	phosphoglycolate phosphatase activity
E4F39_RS12190	COG1530	ribonuclease E activity
E4F39_RS12195	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4F39_RS12205	COG0303	'Molybdopterin
E4F39_RS12220	COG1322	Protein conserved in bacteria
E4F39_RS12240	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
E4F39_RS12250	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
E4F39_RS12265	COG3045	CreA protein
E4F39_RS12285	COG2501	S4 domain
E4F39_RS12290	COG0534	Mate efflux family protein
E4F39_RS12305	COG0114	fumarate hydratase activity
E4F39_RS12330	COG0640	Transcriptional regulator
E4F39_RS12340	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
E4F39_RS12365	COG2204	response regulator
E4F39_RS12380	COG0312	modulator of DNA gyrase
E4F39_RS12390	COG3028	Belongs to the UPF0307 family
E4F39_RS12395	COG0521	Mo-molybdopterin cofactor biosynthetic process
E4F39_RS12405	COG0501	Belongs to the peptidase M48B family
E4F39_RS12420	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
E4F39_RS12505	COG1960	acyl-CoA dehydrogenase activity
E4F39_RS12525	COG2011	ABC-type metal ion transport system permease component
E4F39_RS12535	COG2267	carboxylic ester hydrolase activity
E4F39_RS12545	COG0123	including yeast histone deacetylase and acetoin utilization protein
E4F39_RS12550	COG2951	lytic endotransglycosylase activity
E4F39_RS12575	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E4F39_RS12585	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
E4F39_RS12610	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E4F39_RS12620	COG1605	Chorismate mutase
E4F39_RS12620	COG0077	Prephenate dehydratase
E4F39_RS12625	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E4F39_RS12655	COG0546	phosphoglycolate phosphatase activity
E4F39_RS12670	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4F39_RS12680	COG1910	domain protein
E4F39_RS12695	COG3383	formate dehydrogenase (NAD+) activity
E4F39_RS12735	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4F39_RS12745	COG0154	amidase activity
E4F39_RS12765	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
E4F39_RS12770	COG2252	PERMEase
E4F39_RS12775	COG0402	S-adenosylhomocysteine deaminase activity
E4F39_RS12785	COG2119	membrane
E4F39_RS12800	COG0308	aminopeptidase N
E4F39_RS12810	COG0583	DNA-binding transcription factor activity
E4F39_RS12870	COG4772	TonB-dependent receptor
E4F39_RS12890	COG2176	DNA-directed DNA polymerase activity
E4F39_RS12895	COG1278	Cold shock
E4F39_RS12905	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS12935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E4F39_RS12950	COG1561	YicC-like family, N-terminal region
E4F39_RS12960	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E4F39_RS12965	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4F39_RS13000	COG0477	Major facilitator Superfamily
E4F39_RS13010	COG0859	PFAM glycosyl transferase family 9
E4F39_RS13030	COG2894	cell division
E4F39_RS13075	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E4F39_RS13080	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E4F39_RS13085	COG1674	ftsk spoiiie
E4F39_RS13090	COG0492	ferredoxin-NADP+ reductase activity
E4F39_RS13100	COG2860	membrane
E4F39_RS13105	COG3842	ATPase activity
E4F39_RS13110	COG0395	ABC-type sugar transport system, permease component
E4F39_RS13115	COG1175	transmembrane transport
E4F39_RS13125	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
E4F39_RS13130	COG0363	glucosamine-6-phosphate deaminase activity
E4F39_RS13145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F39_RS13150	COG0765	amino acid transport
E4F39_RS13155	COG1126	abc transporter atp-binding protein
E4F39_RS13170	COG2814	Major facilitator Superfamily
E4F39_RS13195	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4F39_RS13195	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4F39_RS13225	COG0436	Aminotransferase
E4F39_RS13240	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E4F39_RS13275	COG0762	integral membrane protein
E4F39_RS13305	COG2226	methyltransferase
E4F39_RS13345	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E4F39_RS13355	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E4F39_RS13365	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4F39_RS13380	COG0559	Belongs to the binding-protein-dependent transport system permease family
E4F39_RS13390	COG1129	ABC transporter
E4F39_RS13445	COG0859	PFAM glycosyl transferase family 9
E4F39_RS13475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E4F39_RS13490	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E4F39_RS13505	COG1215	transferase activity, transferring glycosyl groups
E4F39_RS13580	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
E4F39_RS13600	COG1773	rubredoxin
E4F39_RS13620	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4F39_RS13635	COG1733	regulation of RNA biosynthetic process
E4F39_RS13640	COG0604	alcohol dehydrogenase
E4F39_RS13700	COG1280	lysine exporter protein (LysE YggA)
E4F39_RS13710	COG0584	glycerophosphoryl diester phosphodiesterase
E4F39_RS13725	COG0730	response to heat
E4F39_RS13770	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4F39_RS13780	COG1120	ATPase activity
E4F39_RS13785	COG4774	siderophore transport
E4F39_RS13810	COG1529	Aldehyde oxidase and xanthine dehydrogenase
E4F39_RS13845	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4F39_RS13855	COG0583	DNA-binding transcription factor activity
E4F39_RS13860	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4F39_RS13870	COG0778	Nitroreductase
E4F39_RS13875	COG2814	Major facilitator Superfamily
E4F39_RS13905	COG2814	Major facilitator Superfamily
E4F39_RS13915	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4F39_RS13945	COG1960	acyl-CoA dehydrogenase activity
E4F39_RS13955	COG0450	alkyl hydroperoxide reductase
E4F39_RS14015	COG4221	oxidoreductase activity
E4F39_RS14020	COG0824	Thioesterase
E4F39_RS14045	COG2885	chlorophyll binding
E4F39_RS14080	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E4F39_RS14080	COG0517	IMP dehydrogenase activity
E4F39_RS14085	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
E4F39_RS14090	COG2877	3-deoxy-8-phosphooctulonate synthase activity
E4F39_RS14105	COG1045	serine acetyltransferase
E4F39_RS14110	COG3562	capsule polysaccharide
E4F39_RS14120	COG3206	protein involved in exopolysaccharide biosynthesis
E4F39_RS14120	COG0489	protein tyrosine kinase activity
E4F39_RS14125	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E4F39_RS14175	COG0156	8-amino-7-oxononanoate synthase activity
E4F39_RS14180	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E4F39_RS14185	COG3321	synthase
E4F39_RS14185	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS14185	COG0604	alcohol dehydrogenase
E4F39_RS14190	COG1368	sulfuric ester hydrolase activity
E4F39_RS14205	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E4F39_RS14305	COG0586	Pfam SNARE associated Golgi protein
E4F39_RS14310	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
E4F39_RS14340	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E4F39_RS14350	COG0617	tRNA 3'-terminal CCA addition
E4F39_RS14355	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E4F39_RS14360	COG1428	Deoxynucleoside kinase
E4F39_RS14370	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E4F39_RS14410	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E4F39_RS14415	COG0497	DNA recombination
E4F39_RS14420	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
E4F39_RS14425	COG3164	Protein of unknown function
E4F39_RS14430	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4F39_RS14435	COG0312	modulator of DNA gyrase
E4F39_RS14445	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4F39_RS14455	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4F39_RS14455	COG1017	nitric oxide dioxygenase activity
E4F39_RS14460	COG2096	Adenosyltransferase
E4F39_RS14465	COG0277	FAD linked oxidase domain protein
E4F39_RS14470	COG0277	FAD linked oxidase domain protein
E4F39_RS14475	COG0277	FAD linked oxidase domain protein
E4F39_RS14480	COG0247	lactate metabolic process
E4F39_RS14500	COG3639	organic phosphonate transmembrane transporter activity
E4F39_RS14505	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
E4F39_RS14510	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4F39_RS14515	COG3454	Phosphonate metabolism
E4F39_RS14520	COG4778	phosphonate C-P lyase system protein PhnL
E4F39_RS14525	COG4107	phosphonate C-P lyase system protein PhnK
E4F39_RS14530	COG3627	carbon phosphorus lyase activity
E4F39_RS14535	COG3626	phosphonate metabolism
E4F39_RS14545	COG3624	Phosphonate C-P lyase system protein PhnG
E4F39_RS14555	COG2188	Transcriptional regulator
E4F39_RS14560	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
E4F39_RS14585	COG0783	Belongs to the Dps family
E4F39_RS14610	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E4F39_RS14625	COG0343	queuine tRNA-ribosyltransferase activity
E4F39_RS14630	COG1862	Preprotein translocase
E4F39_RS14635	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4F39_RS14640	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E4F39_RS14660	COG2353	YceI-like domain
E4F39_RS14665	COG2353	YceI-like domain
E4F39_RS14685	COG2995	paraquat-inducible protein a
E4F39_RS14690	COG3008	intermembrane lipid transfer
E4F39_RS14690	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4F39_RS14780	COG0069	glutamate synthase activity
E4F39_RS14785	COG0625	glutathione transferase activity
E4F39_RS14795	COG0006	proline dipeptidase activity
E4F39_RS14800	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4F39_RS14805	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E4F39_RS14810	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
E4F39_RS14850	COG0588	phosphoglycerate mutase activity
E4F39_RS14860	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E4F39_RS14875	COG0625	glutathione transferase activity
E4F39_RS14880	COG0625	glutathione transferase activity
E4F39_RS14885	COG1917	Cupin 2, conserved barrel domain protein
E4F39_RS14885	COG4977	sequence-specific DNA binding
E4F39_RS14925	COG0418	dihydroorotase activity
E4F39_RS14935	COG0121	glutamine amidotransferase
E4F39_RS14985	COG1126	abc transporter atp-binding protein
E4F39_RS14990	COG0765	amino acid transport
E4F39_RS14995	COG0765	amino acid transport
E4F39_RS15000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F39_RS15005	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
E4F39_RS15015	COG0583	DNA-binding transcription factor activity
E4F39_RS15020	COG2223	nitrite transmembrane transporter activity
E4F39_RS15040	COG0800	Aldolase
E4F39_RS15055	COG0837	glucose binding
E4F39_RS15055	COG1737	Transcriptional regulator
E4F39_RS15070	COG1981	membrane
E4F39_RS15075	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E4F39_RS15080	COG1466	dna polymerase III delta subunit
E4F39_RS15110	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4F39_RS15115	COG0735	belongs to the Fur family
E4F39_RS15120	COG3194	Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source
E4F39_RS15125	COG4266	Belongs to the allantoicase family
E4F39_RS15130	COG1301	dicarboxylic acid transport
E4F39_RS15145	COG0583	DNA-binding transcription factor activity
E4F39_RS15160	COG2814	Major facilitator Superfamily
E4F39_RS15170	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E4F39_RS15175	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E4F39_RS15180	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
E4F39_RS15190	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E4F39_RS15225	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E4F39_RS15230	COG1546	Belongs to the CinA family
E4F39_RS15235	COG0284	orotidine-5'-phosphate decarboxylase activity
E4F39_RS15245	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS15250	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F39_RS15265	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS15275	COG3734	2-keto-3-deoxy-galactonokinase
E4F39_RS15280	COG1414	Transcriptional regulator
E4F39_RS15300	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
E4F39_RS15305	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4F39_RS15310	COG0557	exoribonuclease II activity
E4F39_RS15315	COG3150	esterase
E4F39_RS15320	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
E4F39_RS15330	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4F39_RS15335	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E4F39_RS15340	COG0511	ligase activity, forming carbon-carbon bonds
E4F39_RS15345	COG0439	Biotin carboxylase
E4F39_RS15350	COG2264	protein methyltransferase activity
E4F39_RS15360	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E4F39_RS15365	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4F39_RS15420	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E4F39_RS15425	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
E4F39_RS15430	COG2095	MarC family integral membrane protein
E4F39_RS15485	COG0142	geranyltranstransferase activity
E4F39_RS15495	COG4536	flavin adenine dinucleotide binding
E4F39_RS15500	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
E4F39_RS15525	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
E4F39_RS15530	COG0494	nUDIX hydrolase
E4F39_RS15540	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
E4F39_RS15565	COG0678	peroxiredoxin activity
E4F39_RS15585	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
E4F39_RS15620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E4F39_RS15625	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E4F39_RS15635	COG3116	cell division
E4F39_RS15640	COG0275	rRNA processing
E4F39_RS15655	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS15660	COG0318	PFAM AMP-dependent synthetase and ligase
E4F39_RS15665	COG0243	molybdopterin cofactor binding
E4F39_RS15715	COG1024	Enoyl-CoA hydratase
E4F39_RS15725	COG0183	Belongs to the thiolase family
E4F39_RS15730	COG1024	Enoyl-CoA hydratase
E4F39_RS15735	COG2050	protein possibly involved in aromatic compounds catabolism
E4F39_RS15745	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
E4F39_RS15755	COG2967	ApaG domain
E4F39_RS15765	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E4F39_RS15770	COG0546	phosphoglycolate phosphatase activity
E4F39_RS15785	COG0512	Glutamine amidotransferase of anthranilate synthase
E4F39_RS15805	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E4F39_RS15820	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4F39_RS15825	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4F39_RS15855	COG0012	GTP binding
E4F39_RS15900	COG0584	glycerophosphoryl diester phosphodiesterase
E4F39_RS15915	COG0488	(ABC) transporter
E4F39_RS15930	COG1335	isochorismatase
E4F39_RS15935	COG0006	proline dipeptidase activity
E4F39_RS15965	COG2890	protein-(glutamine-N5) methyltransferase activity
E4F39_RS15970	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
E4F39_RS15980	COG3384	dioxygenase
E4F39_RS15985	COG0531	amino acid
E4F39_RS15990	COG1278	Cold shock
E4F39_RS16000	COG0443	Heat shock 70 kDa protein
E4F39_RS16085	COG0308	aminopeptidase N
E4F39_RS16255	COG2801	Transposase and inactivated derivatives
E4F39_RS16260	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E4F39_RS16270	COG0464	growth
E4F39_RS16285	COG2969	positive regulation of protein catabolic process
E4F39_RS16290	COG0625	glutathione transferase activity
E4F39_RS16295	COG2857	Cytochrome c1
E4F39_RS16300	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E4F39_RS16305	COG0723	plastoquinol--plastocyanin reductase activity
E4F39_RS16310	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E4F39_RS16315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E4F39_RS16325	COG0805	protein transport
E4F39_RS16375	COG2095	MarC family integral membrane protein
E4F39_RS16385	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E4F39_RS16410	COG0842	Transport permease protein
E4F39_RS16415	COG1131	(ABC) transporter
E4F39_RS16440	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E4F39_RS16445	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4F39_RS16450	COG1127	ABC transporter
E4F39_RS16475	COG4178	(ABC) transporter
E4F39_RS16490	COG1115	amino acid carrier protein
E4F39_RS16505	COG0070	glutamate synthase
E4F39_RS16505	COG0069	glutamate synthase activity
E4F39_RS16505	COG0067	glutamate synthase
E4F39_RS16520	COG0584	glycerophosphoryl diester phosphodiesterase
E4F39_RS16525	COG3842	ATPase activity
E4F39_RS16530	COG0395	ABC-type sugar transport system, permease component
E4F39_RS16535	COG1175	transmembrane transport
E4F39_RS16545	COG0232	Belongs to the dGTPase family. Type 2 subfamily
E4F39_RS16600	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E4F39_RS16610	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E4F39_RS16615	COG1333	cytochrome c biogenesis protein
E4F39_RS16635	COG4232	protein-disulfide reductase activity
E4F39_RS16680	COG0201	protein transport
E4F39_RS16815	COG0514	ATP-dependent DNA helicase (RecQ)
E4F39_RS16855	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E4F39_RS16935	COG3396	Phenylacetate-CoA oxygenase
E4F39_RS16940	COG3460	Phenylacetate-CoA oxygenase
E4F39_RS16945	COG3396	Phenylacetate-CoA oxygenase
E4F39_RS16950	COG2151	metal-sulfur cluster biosynthetic enzyme
E4F39_RS16955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
E4F39_RS16975	COG1522	sequence-specific DNA binding
E4F39_RS17005	COG0280	phosphate acetyltransferase
E4F39_RS17005	COG0281	malic enzyme
E4F39_RS17015	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
E4F39_RS17020	COG1881	PFAM PEBP family protein
E4F39_RS17035	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
E4F39_RS17055	COG3047	cAMP biosynthetic process
E4F39_RS17060	COG0583	DNA-binding transcription factor activity
E4F39_RS17070	COG1280	lysine exporter protein (LysE YggA)
E4F39_RS17075	COG2084	Dehydrogenase
E4F39_RS17120	COG1113	amino acid transport
E4F39_RS17135	COG2823	Periplasmic or secreted lipoprotein
E4F39_RS17140	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E4F39_RS17165	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E4F39_RS17175	COG1522	sequence-specific DNA binding
E4F39_RS17180	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E4F39_RS17215	COG2070	2-Nitropropane dioxygenase
E4F39_RS17235	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E4F39_RS17240	COG1950	PFAM Membrane protein of
E4F39_RS17265	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4F39_RS17270	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4F39_RS17290	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
E4F39_RS17295	COG0745	RESPONSE REGULATOR receiver
E4F39_RS17305	COG2201	protein-glutamate methylesterase activity
E4F39_RS17315	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E4F39_RS17335	COG2201	protein-glutamate methylesterase activity
E4F39_RS17340	COG1360	Flagellar Motor Protein
E4F39_RS17365	COG0438	transferase activity, transferring glycosyl groups
E4F39_RS17380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
E4F39_RS17385	COG0561	phosphatase activity
E4F39_RS17395	COG0519	Catalyzes the synthesis of GMP from XMP
E4F39_RS17435	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4F39_RS17450	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS17525	COG2267	carboxylic ester hydrolase activity
E4F39_RS17550	COG3397	chitin binding
E4F39_RS17595	COG0582	viral genome integration into host DNA
E4F39_RS17615	COG3245	cytochrome
E4F39_RS17620	COG0210	DNA helicase
E4F39_RS17640	COG0673	inositol 2-dehydrogenase activity
E4F39_RS17660	COG0509	glycine decarboxylation via glycine cleavage system
E4F39_RS17685	COG1760	l-serine dehydratase
E4F39_RS17715	COG1012	belongs to the aldehyde dehydrogenase family
E4F39_RS17725	COG4302	ethanolamine ammonia-lyase activity
E4F39_RS17735	COG0531	amino acid
E4F39_RS17755	COG0668	transmembrane transport
E4F39_RS17775	COG0789	Transcriptional regulator
E4F39_RS17785	COG0277	FAD linked oxidase domain protein
E4F39_RS17800	COG0436	Aminotransferase
E4F39_RS17820	COG1960	acyl-CoA dehydrogenase activity
E4F39_RS17835	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4F39_RS17835	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
E4F39_RS17835	COG0506	proline dehydrogenase activity
E4F39_RS17855	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E4F39_RS17875	COG1832	CoA-binding protein
E4F39_RS17895	COG0318	PFAM AMP-dependent synthetase and ligase
E4F39_RS17935	COG0356	it plays a direct role in the translocation of protons across the membrane
E4F39_RS17945	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E4F39_RS17950	COG1475	DNA binding
E4F39_RS17955	COG1192	Involved in chromosome partitioning
E4F39_RS18000	COG0559	Belongs to the binding-protein-dependent transport system permease family
E4F39_RS18030	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
E4F39_RS18060	COG1522	sequence-specific DNA binding
E4F39_RS18065	COG3186	Phenylalanine-4-hydroxylase
E4F39_RS18085	COG0642	Histidine kinase
E4F39_RS18105	COG1902	pentaerythritol trinitrate reductase activity
E4F39_RS18110	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E4F39_RS18110	COG0519	Catalyzes the synthesis of GMP from XMP
E4F39_RS18155	COG0523	cobalamin synthesis protein
E4F39_RS18180	COG1459	type II secretion system
E4F39_RS18200	COG2165	general secretion pathway protein
E4F39_RS18235	COG2801	Transposase and inactivated derivatives
E4F39_RS18250	COG1846	Transcriptional regulator
E4F39_RS18255	COG2814	Major facilitator Superfamily
E4F39_RS18260	COG0583	DNA-binding transcription factor activity
E4F39_RS18270	COG1346	cytolysis
E4F39_RS18290	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E4F39_RS18305	COG1987	bacterial-type flagellum assembly
E4F39_RS18315	COG0789	Transcriptional regulator
E4F39_RS18320	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4F39_RS18320	COG4106	trans-aconitate 2-methyltransferase activity
E4F39_RS18330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4F39_RS18340	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4F39_RS18355	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS18380	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS18460	COG1695	Transcriptional regulator
E4F39_RS18495	COG1960	acyl-CoA dehydrogenase activity
E4F39_RS18505	COG0183	Belongs to the thiolase family
E4F39_RS18510	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4F39_RS18510	COG1024	Enoyl-CoA hydratase
E4F39_RS18515	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4F39_RS18560	COG0753	catalase activity
E4F39_RS18585	COG0592	DNA-directed DNA polymerase activity
E4F39_RS18625	COG0582	viral genome integration into host DNA
E4F39_RS18710	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E4F39_RS18740	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E4F39_RS18740	COG2169	Transcriptional regulator
E4F39_RS18755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4F39_RS18785	COG0583	DNA-binding transcription factor activity
E4F39_RS18800	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
E4F39_RS18815	COG4695	Portal protein
E4F39_RS18870	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4F39_RS18875	COG0583	DNA-binding transcription factor activity
E4F39_RS18895	COG0758	DNA mediated transformation
E4F39_RS18900	COG0242	peptide deformylase activity
E4F39_RS18925	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
E4F39_RS18925	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
E4F39_RS18935	COG5000	phosphorelay sensor kinase activity
E4F39_RS18940	COG2204	response regulator
E4F39_RS18960	COG0602	queuosine metabolic process
E4F39_RS18965	COG0720	synthase
E4F39_RS18990	COG0772	Belongs to the SEDS family
E4F39_RS18995	COG0768	penicillin binding
E4F39_RS19010	COG1077	Cell shape determining protein MreB Mrl
E4F39_RS19025	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E4F39_RS19030	COG2326	polyphosphate kinase activity
E4F39_RS19035	COG0708	Exodeoxyribonuclease III
E4F39_RS19045	COG1064	alcohol dehydrogenase
E4F39_RS19050	COG2207	Transcriptional regulator
E4F39_RS19060	COG2814	Major facilitator Superfamily
E4F39_RS19075	COG1309	transcriptional regulator
E4F39_RS19105	COG4567	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain
E4F39_RS19135	COG0523	cobalamin synthesis protein
E4F39_RS19145	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
E4F39_RS19160	COG1560	Kdo2-lipid A biosynthetic process
E4F39_RS19190	COG0667	Aldo Keto reductase
E4F39_RS19210	COG2814	Major facilitator Superfamily
E4F39_RS19220	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
E4F39_RS19235	COG1960	acyl-CoA dehydrogenase activity
E4F39_RS19295	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4F39_RS19310	COG0531	amino acid
E4F39_RS19330	COG1280	lysine exporter protein (LysE YggA)
E4F39_RS19335	COG3568	Endonuclease Exonuclease Phosphatase
E4F39_RS19355	COG0579	oxidoreductase
E4F39_RS19375	COG0747	negative chemotaxis
E4F39_RS19380	COG0601	transmembrane transport
E4F39_RS19385	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4F39_RS19390	COG0444	Belongs to the ABC transporter superfamily
E4F39_RS19425	COG1984	allophanate hydrolase subunit 2
E4F39_RS19430	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E4F39_RS19440	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
E4F39_RS19445	COG0741	lytic transglycosylase activity
E4F39_RS19490	COG2747	anti-sigma28 factor FlgM
E4F39_RS19500	COG1815	bacterial-type flagellum-dependent cell motility
E4F39_RS19505	COG1558	bacterial-type flagellum-dependent cell motility
E4F39_RS19510	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E4F39_RS19515	COG1749	Flagellar hook protein flgE
E4F39_RS19530	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
E4F39_RS19535	COG1706	bacterial-type flagellum-dependent cell motility
E4F39_RS19545	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
E4F39_RS19555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E4F39_RS19565	COG2233	PERMEase
E4F39_RS19575	COG0583	DNA-binding transcription factor activity
E4F39_RS19605	COG2824	Alkylphosphonate utilization operon protein PhnA
E4F39_RS19625	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS19745	COG1704	LemA family
E4F39_RS19750	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
E4F39_RS19770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4F39_RS19775	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F39_RS19795	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E4F39_RS19855	COG1609	Transcriptional regulator
E4F39_RS19860	COG0840	transmembrane signaling receptor activity
E4F39_RS19885	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS19890	COG0583	DNA-binding transcription factor activity
E4F39_RS19905	COG0596	Alpha beta hydrolase
E4F39_RS19935	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E4F39_RS19990	COG1999	signal sequence binding
E4F39_RS20010	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4F39_RS20040	COG4650	regulator
E4F39_RS20085	COG0025	NhaP-type Na H and K H
E4F39_RS20090	COG2200	EAL domain
E4F39_RS20090	COG2199	diguanylate cyclase activity
E4F39_RS20110	COG1785	Belongs to the alkaline phosphatase family
E4F39_RS20140	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E4F39_RS20170	COG0183	Belongs to the thiolase family
E4F39_RS20175	COG0288	reversible hydration of carbon dioxide
E4F39_RS20195	COG0488	(ABC) transporter
E4F39_RS20200	COG0747	negative chemotaxis
E4F39_RS20220	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS20225	COG4221	oxidoreductase activity
E4F39_RS20230	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
E4F39_RS20300	COG1024	Enoyl-CoA hydratase
E4F39_RS20325	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E4F39_RS20335	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E4F39_RS20350	COG0737	Belongs to the 5'-nucleotidase family
E4F39_RS20355	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E4F39_RS20360	COG1127	ABC transporter
E4F39_RS20395	COG1686	Belongs to the peptidase S11 family
E4F39_RS20405	COG2921	Belongs to the UPF0250 family
E4F39_RS20410	COG0583	DNA-binding transcription factor activity
E4F39_RS20435	COG0405	Gamma-glutamyltransferase
E4F39_RS20445	COG0583	DNA-binding transcription factor activity
E4F39_RS20450	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4F39_RS20450	COG1024	Enoyl-CoA hydratase
E4F39_RS20455	COG1960	acyl-CoA dehydrogenase activity
E4F39_RS20460	COG1960	acyl-CoA dehydrogenase activity
E4F39_RS20465	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4F39_RS20475	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4F39_RS20490	COG4191	Histidine kinase
E4F39_RS20500	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
E4F39_RS20540	COG2960	long-chain fatty acid transporting porin activity
E4F39_RS20550	COG0004	ammonium transporteR
E4F39_RS20560	COG0189	ligase activity
E4F39_RS20570	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
E4F39_RS20575	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
E4F39_RS20580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
E4F39_RS20585	COG0793	Belongs to the peptidase S41A family
E4F39_RS20595	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4F39_RS20615	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E4F39_RS20635	COG2226	methyltransferase
E4F39_RS20650	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4F39_RS20660	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
E4F39_RS20690	COG1612	heme a metabolic process
E4F39_RS20700	COG1999	signal sequence binding
E4F39_RS20715	COG0840	transmembrane signaling receptor activity
E4F39_RS20755	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
E4F39_RS20770	COG0587	DNA-directed DNA polymerase activity
E4F39_RS20780	COG2814	Major facilitator Superfamily
E4F39_RS20840	COG0583	DNA-binding transcription factor activity
E4F39_RS20845	COG0477	Major facilitator Superfamily
E4F39_RS20865	COG1104	cysteine desulfurase activity
E4F39_RS20870	COG0477	Major facilitator Superfamily
E4F39_RS20900	COG0583	DNA-binding transcription factor activity
E4F39_RS20905	COG3048	D-serine ammonia-lyase activity
E4F39_RS20915	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS21070	COG1609	Transcriptional regulator
E4F39_RS21090	COG3842	ATPase activity
E4F39_RS21095	COG1653	transport
E4F39_RS21100	COG1175	transmembrane transport
E4F39_RS21105	COG0395	ABC-type sugar transport system, permease component
E4F39_RS21130	COG3436	PFAM IS66 Orf2 family protein
E4F39_RS21140	COG0251	oxidation-reduction process
E4F39_RS21145	COG1301	dicarboxylic acid transport
E4F39_RS21175	COG3209	COG3209 Rhs family protein
E4F39_RS21235	COG0402	S-adenosylhomocysteine deaminase activity
E4F39_RS21255	COG0494	nUDIX hydrolase
E4F39_RS21320	COG1022	Amp-dependent synthetase and ligase
E4F39_RS21330	COG3246	L-lysine catabolic process to acetate
E4F39_RS21345	COG1960	acyl-CoA dehydrogenase activity
E4F39_RS21350	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4F39_RS21355	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS21365	COG1960	acyl-CoA dehydrogenase activity
E4F39_RS21385	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
E4F39_RS21440	COG1253	flavin adenine dinucleotide binding
E4F39_RS21445	COG0583	DNA-binding transcription factor activity
E4F39_RS21480	COG1215	transferase activity, transferring glycosyl groups
E4F39_RS21585	COG0504	CTP synthase activity
E4F39_RS21600	COG0672	)-iron permease
E4F39_RS21670	COG1404	Belongs to the peptidase S8 family
E4F39_RS21680	COG2936	dipeptidyl-peptidase activity
E4F39_RS21685	COG1573	uracil-dna glycosylase
E4F39_RS21840	COG0596	Alpha beta hydrolase
E4F39_RS21875	COG0625	glutathione transferase activity
E4F39_RS21890	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
E4F39_RS21895	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
E4F39_RS21930	COG0295	cytidine deaminase activity
E4F39_RS21940	COG2823	Periplasmic or secreted lipoprotein
E4F39_RS21965	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E4F39_RS21970	COG0280	phosphate acetyltransferase
E4F39_RS21990	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E4F39_RS22005	COG0356	it plays a direct role in the translocation of protons across the membrane
E4F39_RS22015	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E4F39_RS22015	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E4F39_RS22020	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
E4F39_RS22025	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E4F39_RS22045	COG0840	transmembrane signaling receptor activity
E4F39_RS22055	COG0784	Response regulator, receiver
E4F39_RS22055	COG4191	Histidine kinase
E4F39_RS22060	COG0842	Transport permease protein
E4F39_RS22065	COG1129	ABC transporter
E4F39_RS22065	COG0842	Transport permease protein
E4F39_RS22070	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4F39_RS22080	COG1309	transcriptional regulator
E4F39_RS22090	COG0589	response to stress
E4F39_RS22105	COG1136	(ABC) transporter
E4F39_RS22130	COG0840	transmembrane signaling receptor activity
E4F39_RS22170	COG1611	Belongs to the LOG family
E4F39_RS22205	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4F39_RS22215	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS22225	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
E4F39_RS22265	COG0833	amino acid
E4F39_RS22300	COG1335	isochorismatase
E4F39_RS22320	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS22325	COG0633	Ferredoxin
E4F39_RS22325	COG0543	2 iron, 2 sulfur cluster binding
E4F39_RS22330	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E4F39_RS22335	COG4638	Rieske (2fe-2S)
E4F39_RS22340	COG0583	DNA-binding transcription factor activity
E4F39_RS22360	COG1902	pentaerythritol trinitrate reductase activity
E4F39_RS22360	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4F39_RS22380	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
E4F39_RS22410	COG4638	Rieske (2fe-2S)
E4F39_RS22415	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
E4F39_RS22420	COG2146	nitrite reductase [NAD(P)H] activity
E4F39_RS22435	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
E4F39_RS22450	COG2733	membrane
E4F39_RS22455	COG0025	NhaP-type Na H and K H
E4F39_RS22465	COG1012	belongs to the aldehyde dehydrogenase family
E4F39_RS22480	COG0642	Histidine kinase
E4F39_RS22485	COG0840	transmembrane signaling receptor activity
E4F39_RS22525	COG0038	chloride channel
E4F39_RS22560	COG4977	sequence-specific DNA binding
E4F39_RS22570	COG5265	(ABC) transporter
E4F39_RS22580	COG2837	iron assimilation
E4F39_RS22615	COG0583	DNA-binding transcription factor activity
E4F39_RS22640	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS22665	COG2130	NADP-dependent
E4F39_RS22700	COG0628	permease
E4F39_RS22735	COG3795	YCII-related domain
E4F39_RS22740	COG3795	YCII-related domain
E4F39_RS22750	COG4941	Belongs to the sigma-70 factor family
E4F39_RS22765	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4F39_RS22775	COG1592	Rubrerythrin
E4F39_RS22810	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E4F39_RS22830	COG3206	protein involved in exopolysaccharide biosynthesis
E4F39_RS22830	COG0489	protein tyrosine kinase activity
E4F39_RS22850	COG0438	transferase activity, transferring glycosyl groups
E4F39_RS22855	COG0438	transferase activity, transferring glycosyl groups
E4F39_RS22880	COG5642	Protein of unknown function (DUF2384)
E4F39_RS22885	COG5654	RES domain protein
E4F39_RS22890	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
E4F39_RS22930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F39_RS22950	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
E4F39_RS22965	COG4569	acetaldehyde dehydrogenase (acetylating) activity
E4F39_RS23035	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
E4F39_RS23040	COG0352	thiamine-phosphate diphosphorylase activity
E4F39_RS23045	COG1253	flavin adenine dinucleotide binding
E4F39_RS23060	COG0583	DNA-binding transcription factor activity
E4F39_RS23095	COG4149	molybdate abc transporter
E4F39_RS23100	COG0725	ABC transporter, periplasmic molybdate-binding protein
E4F39_RS23125	COG1764	response to oxidative stress
E4F39_RS23130	COG1846	Transcriptional regulator
E4F39_RS23155	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E4F39_RS23165	COG4695	Portal protein
E4F39_RS23205	COG1683	Conserved Protein
E4F39_RS23220	COG1611	Belongs to the LOG family
E4F39_RS23230	COG1252	NADH dehydrogenase
E4F39_RS23250	COG0412	Dienelactone hydrolase
E4F39_RS23270	COG0142	geranyltranstransferase activity
E4F39_RS23295	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E4F39_RS23320	COG2081	HI0933 family
E4F39_RS23380	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4F39_RS23385	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
E4F39_RS23430	COG3038	cytochrome b561
E4F39_RS23440	COG4774	siderophore transport
E4F39_RS23445	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
E4F39_RS23460	COG3842	ATPase activity
E4F39_RS23470	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F39_RS23475	COG1177	transmembrane transport
E4F39_RS23535	COG2831	hemolysin activation secretion protein
E4F39_RS23540	COG3064	Membrane
E4F39_RS23540	COG3210	domain, Protein
E4F39_RS23540	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
E4F39_RS23545	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
E4F39_RS23570	COG2188	Transcriptional regulator
E4F39_RS23580	COG2009	succinate dehydrogenase
E4F39_RS23590	COG1053	succinate dehydrogenase
E4F39_RS23595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4F39_RS23600	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
E4F39_RS23605	COG0372	Belongs to the citrate synthase family
E4F39_RS23635	COG1522	sequence-specific DNA binding
E4F39_RS23660	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4F39_RS23715	COG0135	phosphoribosylanthranilate isomerase activity
E4F39_RS23720	COG0133	tryptophan synthase activity
E4F39_RS23730	COG0159	tryptophan synthase activity
E4F39_RS23735	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E4F39_RS23740	COG0285	dihydrofolate synthase activity
E4F39_RS23775	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4F39_RS23780	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
E4F39_RS23785	COG2755	lipolytic protein G-D-S-L family
E4F39_RS23785	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4F39_RS23805	COG0438	transferase activity, transferring glycosyl groups
E4F39_RS23820	COG1210	Utp--glucose-1-phosphate uridylyltransferase
E4F39_RS23830	COG2755	lipolytic protein G-D-S-L family
E4F39_RS23830	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4F39_RS23855	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS23860	COG1295	ribonuclease BN
E4F39_RS23880	COG3608	succinylglutamate desuccinylase aspartoacylase
E4F39_RS23900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F39_RS23910	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4F39_RS23915	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4F39_RS23930	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F39_RS23955	COG0437	4 iron, 4 sulfur cluster binding
E4F39_RS23960	COG2864	formate dehydrogenase
E4F39_RS23970	COG1921	L-seryl-tRNASec selenium transferase activity
E4F39_RS23975	COG3276	selenocysteine insertion sequence binding
E4F39_RS23995	COG0154	amidase activity
E4F39_RS24005	COG1472	Belongs to the glycosyl hydrolase 3 family
E4F39_RS24050	COG3621	Patatin-like phospholipase
E4F39_RS24090	COG4191	Histidine kinase
E4F39_RS24100	COG2814	Major facilitator Superfamily
E4F39_RS24115	COG0583	DNA-binding transcription factor activity
E4F39_RS24125	COG2030	dehydratase
E4F39_RS24130	COG0427	acetyl-CoA hydrolase
E4F39_RS24135	COG0028	Belongs to the TPP enzyme family
E4F39_RS24230	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4F39_RS24235	COG4789	Type iii secretion
E4F39_RS24250	COG4790	Type iii secretion
E4F39_RS24255	COG4794	Type iii secretion
E4F39_RS24290	COG2207	Transcriptional regulator
E4F39_RS24335	COG1450	Type ii and iii secretion system protein
E4F39_RS24465	COG3550	peptidyl-serine autophosphorylation
E4F39_RS24480	COG1215	transferase activity, transferring glycosyl groups
E4F39_RS24490	COG0457	Tetratricopeptide repeat
E4F39_RS24510	COG1215	transferase activity, transferring glycosyl groups
E4F39_RS24515	COG2194	sulfuric ester hydrolase activity
E4F39_RS24525	COG2175	clavaminate synthase activity
E4F39_RS24535	COG4521	taurine ABC transporter
E4F39_RS24545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
E4F39_RS24575	COG0318	PFAM AMP-dependent synthetase and ligase
E4F39_RS24595	COG0306	phosphate transporter
E4F39_RS24610	COG1522	sequence-specific DNA binding
E4F39_RS24615	COG1280	lysine exporter protein (LysE YggA)
E4F39_RS24650	COG0477	Major facilitator Superfamily
E4F39_RS24800	COG4790	Type iii secretion
E4F39_RS24835	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4F39_RS24850	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4F39_RS24935	COG0302	gtp cyclohydrolase
E4F39_RS25075	COG5295	Hep Hag repeat protein
E4F39_RS25085	COG3023	N-Acetylmuramoyl-L-alanine amidase
E4F39_RS25120	COG5564	TIM-barrel signal transduction protein
E4F39_RS25125	COG5441	Belongs to the UPF0261 family
E4F39_RS25165	COG1063	alcohol dehydrogenase
E4F39_RS25170	COG4948	Mandelate Racemase Muconate Lactonizing
E4F39_RS25180	COG0246	Mannitol dehydrogenase
E4F39_RS25190	COG2271	Major facilitator Superfamily
E4F39_RS25200	COG1349	DNA-binding transcription factor activity
E4F39_RS25225	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4F39_RS25240	COG0583	DNA-binding transcription factor activity
E4F39_RS25255	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F39_RS25260	COG1012	belongs to the aldehyde dehydrogenase family
E4F39_RS25265	COG1477	protein flavinylation
E4F39_RS25310	COG2271	Major facilitator Superfamily
E4F39_RS25350	COG4638	Rieske (2fe-2S)
E4F39_RS25400	COG1960	acyl-CoA dehydrogenase activity
E4F39_RS25405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
E4F39_RS25445	COG5295	Hep Hag repeat protein
E4F39_RS25445	COG5295	Hep Hag repeat protein
E4F39_RS25470	COG0798	PFAM Bile acid sodium symporter
E4F39_RS25485	COG0640	Transcriptional regulator
E4F39_RS25520	COG4175	Glycine betaine
E4F39_RS25570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4F39_RS25575	COG3622	Belongs to the hyi family
E4F39_RS25580	COG2271	Major facilitator Superfamily
E4F39_RS25585	COG0235	Class ii aldolase
E4F39_RS25590	COG3395	kinase activity
E4F39_RS25595	COG2084	Dehydrogenase
E4F39_RS25600	COG2186	Transcriptional regulator
E4F39_RS25680	COG4789	Type iii secretion
E4F39_RS25685	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E4F39_RS25730	COG2207	Transcriptional regulator
E4F39_RS25735	COG1450	Type ii and iii secretion system protein
E4F39_RS25770	COG4644	lycopene metabolic process
E4F39_RS25780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4F39_RS25810	COG1285	pathogenesis
E4F39_RS25825	COG1271	oxidase subunit
E4F39_RS25830	COG1294	oxidase, subunit
E4F39_RS25870	COG1760	l-serine dehydratase
E4F39_RS25890	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4F39_RS25890	COG0404	The glycine cleavage system catalyzes the degradation of glycine
E4F39_RS25930	COG1278	Cold shock
E4F39_RS25960	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E4F39_RS25975	COG4251	negative regulation of phosphorylation
E4F39_RS25980	COG0784	Response regulator, receiver
E4F39_RS25990	COG0477	Major facilitator Superfamily
E4F39_RS26045	COG2814	Major facilitator Superfamily
E4F39_RS26075	COG1621	beta-fructofuranosidase activity
E4F39_RS26120	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4F39_RS26120	COG1902	pentaerythritol trinitrate reductase activity
E4F39_RS26125	COG2181	nitrate reductase activity
E4F39_RS26125	COG0247	lactate metabolic process
E4F39_RS26130	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
E4F39_RS26150	COG2113	Glycine betaine
E4F39_RS26165	COG0583	DNA-binding transcription factor activity
E4F39_RS26170	COG3119	arylsulfatase activity
E4F39_RS26210	COG3246	L-lysine catabolic process to acetate
E4F39_RS26215	COG1250	3-hydroxyacyl-CoA dehydrogenase
E4F39_RS26225	COG0657	acetylesterase activity
E4F39_RS26320	COG1021	2,3-dihydroxybenzoate-AMP ligase
E4F39_RS26360	COG1132	(ABC) transporter
E4F39_RS26400	COG3284	Transcriptional regulator
E4F39_RS26425	COG2252	PERMEase
E4F39_RS26470	COG1012	belongs to the aldehyde dehydrogenase family
E4F39_RS26480	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E4F39_RS26480	COG0028	Belongs to the TPP enzyme family
E4F39_RS26515	COG0330	HflC and HflK could
E4F39_RS26530	COG1960	acyl-CoA dehydrogenase activity
E4F39_RS26535	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E4F39_RS26550	COG1024	Enoyl-CoA hydratase
E4F39_RS26555	COG1024	Enoyl-CoA hydratase
E4F39_RS26565	COG1538	Outer membrane efflux protein
E4F39_RS26575	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4F39_RS26605	COG2066	Belongs to the glutaminase family
E4F39_RS26615	COG0745	RESPONSE REGULATOR receiver
E4F39_RS26620	COG2205	protein histidine kinase activity
E4F39_RS26705	COG0642	Histidine kinase
E4F39_RS26735	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E4F39_RS26885	COG3291	Pkd domain containing protein
E4F39_RS26905	COG3214	Protein conserved in bacteria
E4F39_RS26915	COG0477	Major facilitator Superfamily
E4F39_RS26925	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
E4F39_RS26945	COG1845	cytochrome c oxidase, subunit III
E4F39_RS27005	COG2207	Transcriptional regulator
E4F39_RS27055	COG2205	protein histidine kinase activity
E4F39_RS27075	COG1846	Transcriptional regulator
E4F39_RS27090	COG1012	belongs to the aldehyde dehydrogenase family
E4F39_RS27095	COG3384	dioxygenase
E4F39_RS27105	COG3971	2-oxopent-4-enoate hydratase activity
E4F39_RS27130	COG3842	ATPase activity
E4F39_RS27135	COG4208	sulfate ABC transporter
E4F39_RS27150	COG0642	Histidine kinase
E4F39_RS27160	COG3217	Mosc domain protein beta barrel domain protein
E4F39_RS27160	COG0633	Ferredoxin
E4F39_RS27170	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS27190	COG1024	Enoyl-CoA hydratase
E4F39_RS27215	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4F39_RS27220	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
E4F39_RS27255	COG1309	transcriptional regulator
E4F39_RS27275	COG1902	pentaerythritol trinitrate reductase activity
E4F39_RS27290	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E4F39_RS27305	COG0628	permease
E4F39_RS27320	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS27355	COG0318	PFAM AMP-dependent synthetase and ligase
E4F39_RS27365	COG0840	transmembrane signaling receptor activity
E4F39_RS27375	COG1215	transferase activity, transferring glycosyl groups
E4F39_RS27480	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS27525	COG0583	DNA-binding transcription factor activity
E4F39_RS27550	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS27565	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
E4F39_RS27570	COG2508	Transcriptional regulator
E4F39_RS27575	COG0402	S-adenosylhomocysteine deaminase activity
E4F39_RS27620	COG1858	cytochrome C peroxidase
E4F39_RS27625	COG3511	phospholipase C
E4F39_RS27645	COG2197	response regulator
E4F39_RS27720	COG1024	Enoyl-CoA hydratase
E4F39_RS27725	COG1012	belongs to the aldehyde dehydrogenase family
E4F39_RS27730	COG3320	Male sterility
E4F39_RS27730	COG1022	Amp-dependent synthetase and ligase
E4F39_RS27735	COG2814	Major facilitator Superfamily
E4F39_RS27745	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS27770	COG1129	ABC transporter
E4F39_RS27775	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F39_RS27785	COG2721	sulfolactate sulfo-lyase activity
E4F39_RS27800	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS27810	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS27835	COG5295	Hep Hag repeat protein
E4F39_RS27835	COG5295	Hep Hag repeat protein
E4F39_RS27845	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4F39_RS27900	COG1272	protein, Hemolysin III
E4F39_RS27920	COG1522	sequence-specific DNA binding
E4F39_RS27935	COG1448	Aminotransferase
E4F39_RS27990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F39_RS27990	COG4191	Histidine kinase
E4F39_RS27995	COG2201	protein-glutamate methylesterase activity
E4F39_RS28060	COG2175	clavaminate synthase activity
E4F39_RS28065	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E4F39_RS28085	COG3291	Pkd domain containing protein
E4F39_RS28100	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
E4F39_RS28175	COG0589	response to stress
E4F39_RS28215	COG4221	oxidoreductase activity
E4F39_RS28230	COG1113	amino acid transport
E4F39_RS28245	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4F39_RS28300	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
E4F39_RS28345	COG0583	DNA-binding transcription factor activity
E4F39_RS28355	COG0583	DNA-binding transcription factor activity
E4F39_RS28390	COG1012	belongs to the aldehyde dehydrogenase family
E4F39_RS28395	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4F39_RS28400	COG0531	amino acid
E4F39_RS28415	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS28435	COG1902	pentaerythritol trinitrate reductase activity
E4F39_RS28455	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS28460	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
E4F39_RS28475	COG0516	GMP reductase activity
E4F39_RS28475	COG0517	IMP dehydrogenase activity
E4F39_RS28480	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4F39_RS28505	COG2197	response regulator
E4F39_RS28510	COG1285	pathogenesis
E4F39_RS28520	COG1408	metallophosphoesterase
E4F39_RS28535	COG1414	Transcriptional regulator
E4F39_RS28540	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS28550	COG2146	nitrite reductase [NAD(P)H] activity
E4F39_RS28580	COG1414	Transcriptional regulator
E4F39_RS28585	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS28590	COG0028	Belongs to the TPP enzyme family
E4F39_RS28600	COG1012	belongs to the aldehyde dehydrogenase family
E4F39_RS28615	COG0477	Major facilitator Superfamily
E4F39_RS28645	COG0154	amidase activity
E4F39_RS28655	COG1522	sequence-specific DNA binding
E4F39_RS28735	COG0596	Alpha beta hydrolase
E4F39_RS28765	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4F39_RS28790	COG0840	transmembrane signaling receptor activity
E4F39_RS28810	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4F39_RS28815	COG0596	Alpha beta hydrolase
E4F39_RS28865	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS28900	COG0583	DNA-binding transcription factor activity
E4F39_RS28925	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4F39_RS28930	COG0601	transmembrane transport
E4F39_RS28940	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
E4F39_RS28975	COG3209	COG3209 Rhs family protein
E4F39_RS29020	COG2140	Oxalate decarboxylase
E4F39_RS29025	COG1914	H( )-stimulated, divalent metal cation uptake system
E4F39_RS29035	COG4682	membrane
E4F39_RS29040	COG3781	membrane
E4F39_RS29045	COG0243	molybdopterin cofactor binding
E4F39_RS29050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F39_RS29075	COG1404	Belongs to the peptidase S8 family
E4F39_RS29100	COG2259	Doxx family
E4F39_RS29125	COG4160	amino acid transport
E4F39_RS29135	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
E4F39_RS29190	COG3275	phosphorelay sensor kinase activity
E4F39_RS29215	COG0500	methyltransferase
E4F39_RS29220	COG2207	Transcriptional regulator
E4F39_RS29240	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E4F39_RS29245	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4F39_RS29250	COG1024	Enoyl-CoA hydratase
E4F39_RS29255	COG1024	Enoyl-CoA hydratase
E4F39_RS29260	COG3425	synthase
E4F39_RS29280	COG3547	Transposase (IS116 IS110 IS902 family)
E4F39_RS29295	COG0475	glutathione-regulated potassium exporter activity
E4F39_RS29295	COG0569	domain protein
E4F39_RS29320	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E4F39_RS29320	COG3321	synthase
E4F39_RS29320	COG4221	oxidoreductase activity
E4F39_RS29320	COG0300	oxidoreductase activity
E4F39_RS29355	COG0583	DNA-binding transcription factor activity
E4F39_RS29365	COG0387	Pfam Sodium calcium exchanger
E4F39_RS29390	COG0179	Fumarylacetoacetate (FAA) hydrolase
E4F39_RS29495	COG4386	tail sheath protein
E4F39_RS29565	COG0776	regulation of translation
E4F39_RS29595	COG2842	Transposition protein
E4F39_RS29640	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
E4F39_RS29685	COG1595	DNA-templated transcription, initiation
E4F39_RS29695	COG4774	siderophore transport
E4F39_RS29700	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F39_RS29705	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F39_RS29745	COG1960	acyl-CoA dehydrogenase activity
E4F39_RS29755	COG2271	Major facilitator Superfamily
E4F39_RS29840	COG0686	Belongs to the AlaDH PNT family
E4F39_RS29880	COG0443	Heat shock 70 kDa protein
E4F39_RS29885	COG0443	Heat shock 70 kDa protein
E4F39_RS29935	COG2264	protein methyltransferase activity
E4F39_RS29980	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E4F39_RS30045	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
E4F39_RS30060	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E4F39_RS30075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
E4F39_RS30080	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4F39_RS30080	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E4F39_RS30125	COG1902	pentaerythritol trinitrate reductase activity
E4F39_RS30125	COG0446	pyridine nucleotide-disulphide oxidoreductase
E4F39_RS30130	COG1695	Transcriptional regulator
E4F39_RS30180	COG3260	NADH ubiquinone oxidoreductase 20
E4F39_RS30185	COG0649	NAD binding
E4F39_RS30190	COG0651	ATP synthesis coupled electron transport
E4F39_RS30200	COG0650	Formate hydrogenlyase subunit 4
E4F39_RS30205	COG0651	ATP synthesis coupled electron transport
E4F39_RS30245	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E4F39_RS30250	COG2181	nitrate reductase activity
E4F39_RS30255	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
E4F39_RS30260	COG1140	nitrate reductase beta subunit
E4F39_RS30265	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
E4F39_RS30275	COG3851	Histidine kinase
E4F39_RS30300	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4F39_RS30325	COG2175	clavaminate synthase activity
E4F39_RS30345	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
E4F39_RS30370	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F39_RS30375	COG0339	signal peptide processing
E4F39_RS30395	COG0475	glutathione-regulated potassium exporter activity
E4F39_RS30455	COG0318	PFAM AMP-dependent synthetase and ligase
E4F39_RS30460	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4F39_RS30520	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4F39_RS30540	COG0540	Belongs to the ATCase OTCase family
E4F39_RS30620	COG0477	Major facilitator Superfamily
E4F39_RS30625	COG0352	thiamine-phosphate diphosphorylase activity
E4F39_RS30645	COG0840	transmembrane signaling receptor activity
E4F39_RS30675	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS30680	COG4651	solute:proton antiporter activity
E4F39_RS30680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E4F39_RS30735	COG1349	DNA-binding transcription factor activity
E4F39_RS30740	COG2223	nitrite transmembrane transporter activity
E4F39_RS30785	COG1063	alcohol dehydrogenase
E4F39_RS30790	COG3842	ATPase activity
E4F39_RS30830	COG2146	nitrite reductase [NAD(P)H] activity
E4F39_RS30835	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4F39_RS30855	COG3707	response regulator
E4F39_RS30860	COG1116	anion transmembrane transporter activity
E4F39_RS30860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
E4F39_RS30870	COG0302	gtp cyclohydrolase
E4F39_RS30910	COG0477	Major facilitator Superfamily
E4F39_RS30915	COG0583	DNA-binding transcription factor activity
E4F39_RS30930	COG0583	DNA-binding transcription factor activity
E4F39_RS30965	COG2130	NADP-dependent
E4F39_RS30970	COG1979	alcohol dehydrogenase
E4F39_RS31075	COG0318	PFAM AMP-dependent synthetase and ligase
E4F39_RS31110	COG1739	Uncharacterized protein family UPF0029
E4F39_RS31140	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E4F39_RS31180	COG2274	protein secretion by the type I secretion system
E4F39_RS31255	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
E4F39_RS31260	COG4122	O-methyltransferase activity
E4F39_RS31270	COG5001	Diguanylate cyclase
E4F39_RS31270	COG4251	negative regulation of phosphorylation
E4F39_RS31270	COG3706	GGDEF domain
E4F39_RS31270	COG2203	Gaf domain
E4F39_RS31300	COG3485	protocatechuate 3,4-dioxygenase
E4F39_RS31305	COG3485	protocatechuate 3,4-dioxygenase
E4F39_RS31320	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4F39_RS31325	COG0601	transmembrane transport
E4F39_RS31330	COG0747	negative chemotaxis
E4F39_RS31340	COG4172	Belongs to the ABC transporter superfamily
E4F39_RS31345	COG1446	asparaginase
E4F39_RS31355	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
E4F39_RS31405	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E4F39_RS31415	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E4F39_RS31425	COG0277	FAD linked oxidase domain protein
E4F39_RS31480	COG2188	Transcriptional regulator
E4F39_RS31485	COG2814	Major facilitator Superfamily
E4F39_RS31500	COG1858	cytochrome C peroxidase
E4F39_RS31505	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
E4F39_RS31530	COG0456	acetyltransferase
E4F39_RS31530	COG0454	-acetyltransferase
E4F39_RS31540	COG2391	methyltransferase activity
E4F39_RS31545	COG0640	Transcriptional regulator
E4F39_RS31555	COG3038	cytochrome b561
E4F39_RS31560	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E4F39_RS31565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4F39_RS31575	COG1045	serine acetyltransferase
E4F39_RS31590	COG1505	serine-type exopeptidase activity
E4F39_RS31600	COG1566	PFAM secretion protein HlyD family protein
E4F39_RS31790	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
E4F39_RS31790	COG0028	Belongs to the TPP enzyme family
E4F39_RS31795	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
E4F39_RS31805	COG4977	sequence-specific DNA binding
E4F39_RS31825	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F39_RS31830	COG1305	Transglutaminase-like
E4F39_RS31860	COG2308	Evidence 4 Homologs of previously reported genes of
E4F39_RS31870	COG0778	Nitroreductase
E4F39_RS31895	COG3634	alkyl hydroperoxide reductase activity
E4F39_RS31925	COG0318	PFAM AMP-dependent synthetase and ligase
E4F39_RS31945	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E4F39_RS31980	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E4F39_RS31990	COG0010	Belongs to the arginase family
E4F39_RS31995	COG1012	belongs to the aldehyde dehydrogenase family
E4F39_RS32000	COG1396	sequence-specific DNA binding
E4F39_RS32000	COG1917	Cupin 2, conserved barrel domain protein
E4F39_RS32015	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E4F39_RS32020	COG0174	glutamine synthetase
E4F39_RS32035	COG3842	ATPase activity
E4F39_RS32040	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F39_RS32045	COG1177	transmembrane transport
E4F39_RS32060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4F39_RS32105	COG1796	DNA polymerase
E4F39_RS32105	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
E4F39_RS32140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
E4F39_RS32150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4F39_RS32200	COG1574	metal-dependent hydrolase with the TIM-barrel fold
E4F39_RS32210	COG1335	isochorismatase
E4F39_RS32215	COG0583	DNA-binding transcription factor activity
E4F39_RS32225	COG2814	Major facilitator Superfamily
E4F39_RS32265	COG1741	Belongs to the pirin family
E4F39_RS32270	COG0583	DNA-binding transcription factor activity
E4F39_RS32320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E4F39_RS32370	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E4F39_RS32570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E4F39_RS32605	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E4F39_RS32655	COG3193	protein, possibly involved in utilization of glycolate and propanediol
E4F39_RS32665	COG0672	)-iron permease
E4F39_RS32670	COG4633	Protein conserved in bacteria
E4F39_RS32680	COG0556	nucleotide-excision repair
E4F39_RS32695	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS32700	COG0667	Aldo Keto reductase
E4F39_RS32705	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
E4F39_RS32720	COG0789	Transcriptional regulator
E4F39_RS32775	COG1012	belongs to the aldehyde dehydrogenase family
E4F39_RS32790	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F39_RS32815	COG2271	Major facilitator Superfamily
E4F39_RS32820	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E4F39_RS32825	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E4F39_RS32870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E4F39_RS32885	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E4F39_RS32895	COG0531	amino acid
E4F39_RS32905	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
E4F39_RS32930	COG2259	Doxx family
E4F39_RS32945	COG1556	Lactate utilization protein
E4F39_RS32950	COG1139	Iron-sulfur cluster binding protein
E4F39_RS32955	COG0247	lactate metabolic process
E4F39_RS32960	COG2186	Transcriptional regulator
E4F39_RS32990	COG2011	ABC-type metal ion transport system permease component
E4F39_RS32995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E4F39_RS33015	COG2197	response regulator
E4F39_RS33065	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4F39_RS33080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E4F39_RS33090	COG0019	diaminopimelate decarboxylase activity
E4F39_RS33095	COG0318	PFAM AMP-dependent synthetase and ligase
E4F39_RS33140	COG1301	dicarboxylic acid transport
E4F39_RS33155	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E4F39_RS33160	COG0657	acetylesterase activity
E4F39_RS33165	COG0583	DNA-binding transcription factor activity
E4F39_RS33195	COG1942	4-Oxalocrotonate Tautomerase
E4F39_RS33200	COG0583	DNA-binding transcription factor activity
E4F39_RS33205	COG0709	Synthesizes selenophosphate from selenide and ATP
E4F39_RS33240	COG1414	Transcriptional regulator
E4F39_RS33245	COG1288	antiporter activity
E4F39_RS33255	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
E4F39_RS33295	COG0840	transmembrane signaling receptor activity
E4F39_RS33310	COG0183	Belongs to the thiolase family
E4F39_RS33320	COG1414	Transcriptional regulator
E4F39_RS33325	COG1309	transcriptional regulator
E4F39_RS33340	COG1473	amidohydrolase
E4F39_RS33345	COG0583	DNA-binding transcription factor activity
E4F39_RS33360	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
E4F39_RS33360	COG2755	lipolytic protein G-D-S-L family
E4F39_RS33390	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS33425	COG2376	Dihydroxyacetone kinase
E4F39_RS33430	COG1063	alcohol dehydrogenase
E4F39_RS33435	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS33440	COG1879	ABC-type sugar transport system periplasmic component
E4F39_RS33445	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F39_RS33450	COG1129	ABC transporter
E4F39_RS33455	COG0698	ribose 5-phosphate isomerase
E4F39_RS33465	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS33480	COG1840	ABC-type Fe3 transport system, periplasmic component
E4F39_RS33485	COG3842	ATPase activity
E4F39_RS33515	COG3720	iron ion transport
E4F39_RS33520	COG4558	Periplasmic binding protein
E4F39_RS33530	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E4F39_RS33535	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
E4F39_RS33540	COG2860	membrane
E4F39_RS33560	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
E4F39_RS33570	COG1271	oxidase subunit
E4F39_RS33575	COG1294	oxidase, subunit
E4F39_RS33600	COG1562	ergosterol biosynthetic process
E4F39_RS33610	COG0346	lactoylglutathione lyase activity
E4F39_RS33700	COG1285	pathogenesis
E4F39_RS33725	COG0840	transmembrane signaling receptor activity
E4F39_RS33735	COG0535	radical SAM domain protein
E4F39_RS33800	COG0840	transmembrane signaling receptor activity
E4F39_RS33860	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E4F39_RS33865	COG0511	ligase activity, forming carbon-carbon bonds
E4F39_RS33880	COG1984	allophanate hydrolase subunit 2
E4F39_RS33935	COG0583	DNA-binding transcription factor activity
E4F39_RS34050	COG2885	chlorophyll binding
E4F39_RS34090	COG0367	asparagine synthase
E4F39_RS34120	COG3537	Alpha-1,2-mannosidase
E4F39_RS34150	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS34205	COG0583	DNA-binding transcription factor activity
E4F39_RS34210	COG1473	amidohydrolase
E4F39_RS34225	COG0513	Belongs to the DEAD box helicase family
E4F39_RS34260	COG1172	Belongs to the binding-protein-dependent transport system permease family
E4F39_RS34265	COG1879	ABC-type sugar transport system periplasmic component
E4F39_RS34315	COG2203	Gaf domain
E4F39_RS34315	COG5001	Diguanylate cyclase
E4F39_RS34315	COG4251	negative regulation of phosphorylation
E4F39_RS34315	COG3706	GGDEF domain
E4F39_RS34350	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
E4F39_RS34350	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS34350	COG3321	synthase
E4F39_RS34350	COG0318	PFAM AMP-dependent synthetase and ligase
E4F39_RS34350	COG0300	oxidoreductase activity
E4F39_RS34365	COG3835	regulator
E4F39_RS34370	COG0469	pyruvate kinase activity
E4F39_RS34375	COG1929	Belongs to the glycerate kinase type-1 family
E4F39_RS34380	COG2271	Major facilitator Superfamily
E4F39_RS34400	COG3547	Transposase (IS116 IS110 IS902 family)
E4F39_RS34425	COG3188	usher protein
E4F39_RS34565	COG2885	chlorophyll binding
E4F39_RS34580	COG3188	usher protein
E4F39_RS34585	COG3121	Chaperone
E4F39_RS34610	COG5295	Hep Hag repeat protein
E4F39_RS34640	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
E4F39_RS34680	COG0432	Pfam Uncharacterised protein family UPF0047
E4F39_RS34725	COG1177	transmembrane transport
E4F39_RS34730	COG1176	ABC-type spermidine putrescine transport system, permease component I
E4F39_RS34825	COG0477	Major facilitator Superfamily
E4F39_RS34840	COG2916	Histone family protein nucleoid-structuring protein H-NS
E4F39_RS34875	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E4F39_RS34880	COG1595	DNA-templated transcription, initiation
E4F39_RS34960	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
E4F39_RS34965	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
E4F39_RS34970	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E4F39_RS34975	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
E4F39_RS34995	COG0302	gtp cyclohydrolase
E4F39_RS35010	COG1045	serine acetyltransferase
E4F39_RS35060	COG0589	response to stress
E4F39_RS35065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
E4F39_RS35070	COG0583	DNA-binding transcription factor activity
E4F39_RS35145	COG0671	phosphoesterase, PA-phosphatase related
E4F39_RS35155	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS35180	COG0625	glutathione transferase activity
E4F39_RS35195	COG0583	DNA-binding transcription factor activity
E4F39_RS35200	COG0473	3-isopropylmalate dehydrogenase activity
E4F39_RS35225	COG1309	transcriptional regulator
E4F39_RS35250	COG1396	sequence-specific DNA binding
E4F39_RS35295	COG1192	Involved in chromosome partitioning
E4F39_RS35305	COG1393	Belongs to the ArsC family
E4F39_RS35315	COG1595	DNA-templated transcription, initiation
E4F39_RS35365	COG1562	ergosterol biosynthetic process
E4F39_RS35375	COG1657	PFAM Prenyltransferase squalene oxidase
E4F39_RS35390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E4F39_RS35395	COG0765	amino acid transport
E4F39_RS35400	COG1126	abc transporter atp-binding protein
E4F39_RS35410	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E4F39_RS35440	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS35450	COG2072	flavoprotein involved in K transport
E4F39_RS35455	COG1136	(ABC) transporter
E4F39_RS35500	COG3447	MASE1 domain protein
E4F39_RS35500	COG5002	protein histidine kinase activity
E4F39_RS35500	COG5001	Diguanylate cyclase
E4F39_RS35565	COG0454	-acetyltransferase
E4F39_RS35565	COG0456	acetyltransferase
E4F39_RS35590	COG0154	amidase activity
E4F39_RS35600	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS35665	COG3302	dmso reductase anchor subunit
E4F39_RS35670	COG0437	4 iron, 4 sulfur cluster binding
E4F39_RS35675	COG0243	molybdopterin cofactor binding
E4F39_RS35700	COG3246	L-lysine catabolic process to acetate
E4F39_RS35705	COG2175	clavaminate synthase activity
E4F39_RS35720	COG2909	trisaccharide binding
E4F39_RS35745	COG0071	Belongs to the small heat shock protein (HSP20) family
E4F39_RS35760	COG2239	Acts as a magnesium transporter
E4F39_RS35825	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
E4F39_RS35885	COG0022	dehydrogenase e1 component
E4F39_RS35915	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
E4F39_RS35935	COG2091	lysine biosynthetic process via aminoadipic acid
E4F39_RS35945	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
E4F39_RS35950	COG2084	Dehydrogenase
E4F39_RS35965	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E4F39_RS35970	COG0688	phosphatidylethanolamine metabolic process
E4F39_RS36005	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS36020	COG2192	nodulation
E4F39_RS36085	COG2823	Periplasmic or secreted lipoprotein
E4F39_RS36090	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS36115	COG1028	Short-chain dehydrogenase reductase Sdr
E4F39_RS36135	COG1914	H( )-stimulated, divalent metal cation uptake system
E4F39_RS36140	COG1573	uracil-dna glycosylase
E4F39_RS36160	COG0516	GMP reductase activity
E4F39_RS36160	COG0517	IMP dehydrogenase activity
E4F39_RS36250	COG3685	Protein conserved in bacteria
E4F39_RS36255	COG3546	catalase activity
E4F39_RS36265	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E4F39_RS36350	COG2271	Major facilitator Superfamily
E4F39_RS36370	COG1113	amino acid transport
E4F39_RS36375	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
E4F39_RS36390	COG1522	sequence-specific DNA binding
E4F39_RS36435	COG4964	Belongs to the GSP D family
E4F39_RS36485	COG0463	Glycosyl transferase, family 2
E4F39_RS36540	COG1966	Carbon starvation protein
E4F39_RS36545	COG2879	small protein
E4F39_RS36565	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
E4F39_RS36585	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E4F39_RS36615	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E4F39_RS36665	COG1804	L-carnitine dehydratase bile acid-inducible protein F
E4F39_RS36680	COG2801	Transposase and inactivated derivatives
E4F39_RS36715	COG3104	oligopeptide transport
E4F39_RS36740	COG0601	transmembrane transport
E4F39_RS36745	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E4F39_RS36795	COG2610	gluconate transmembrane transporter activity
E4F39_RS36820	COG2916	Histone family protein nucleoid-structuring protein H-NS