locus-tag	class	description
A4V04_RS00005	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A4V04_RS00010	COG0443	Heat shock 70 kDa protein
A4V04_RS00015	COG0633	Ferredoxin
A4V04_RS00020	COG2975	iron-sulfur cluster assembly
A4V04_RS00035	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A4V04_RS00045	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A4V04_RS00050	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A4V04_RS00065	COG1136	(ABC) transporter
A4V04_RS00080	COG2848	UPF0210 protein
A4V04_RS00085	COG0251	oxidation-reduction process
A4V04_RS00090	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4V04_RS00100	COG0583	DNA-binding transcription factor activity
A4V04_RS00140	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4V04_RS00145	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A4V04_RS00160	COG0776	regulation of translation
A4V04_RS00165	COG0072	phenylalanine-tRNA ligase activity
A4V04_RS00165	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V04_RS00170	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A4V04_RS00175	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A4V04_RS00180	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A4V04_RS00185	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A4V04_RS00190	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A4V04_RS00205	COG0731	radical SAM domain protein
A4V04_RS00205	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A4V04_RS00215	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
A4V04_RS00220	COG4942	peptidase
A4V04_RS00225	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A4V04_RS00245	COG0105	UTP biosynthetic process
A4V04_RS00250	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A4V04_RS00260	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A4V04_RS00265	COG0124	histidyl-tRNA synthetase
A4V04_RS00270	COG2976	Protein conserved in bacteria
A4V04_RS00275	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4V04_RS00280	COG1160	GTP binding
A4V04_RS00285	COG1923	regulation of RNA biosynthetic process
A4V04_RS00290	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
A4V04_RS00295	COG0330	HflC and HflK could
A4V04_RS00300	COG0330	HflC and HflK could
A4V04_RS00310	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
A4V04_RS00315	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A4V04_RS00325	COG1763	Mo-molybdopterin cofactor biosynthetic process
A4V04_RS00330	COG0303	'Molybdopterin
A4V04_RS00335	COG0314	molybdopterin synthase activity
A4V04_RS00360	COG1473	amidohydrolase
A4V04_RS00365	COG1473	amidohydrolase
A4V04_RS00605	COG3646	Phage regulatory protein
A4V04_RS00615	COG1598	PFAM Uncharacterised protein family UPF0150
A4V04_RS00660	COG2308	Evidence 4 Homologs of previously reported genes of
A4V04_RS00670	COG1305	Transglutaminase-like
A4V04_RS00685	COG1739	Uncharacterized protein family UPF0029
A4V04_RS00710	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4V04_RS00730	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A4V04_RS00735	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4V04_RS00740	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A4V04_RS00750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A4V04_RS00755	COG0563	adenylate kinase activity
A4V04_RS00760	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A4V04_RS00765	COG2835	tetraacyldisaccharide 4'-kinase activity
A4V04_RS00765	COG1663	tetraacyldisaccharide 4'-kinase activity
A4V04_RS00770	COG1663	tetraacyldisaccharide 4'-kinase activity
A4V04_RS00775	COG1570	exodeoxyribonuclease VII activity
A4V04_RS00780	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A4V04_RS00790	COG1278	Cold shock
A4V04_RS00795	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
A4V04_RS00800	COG0542	response to heat
A4V04_RS00810	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A4V04_RS00815	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A4V04_RS00825	COG0196	riboflavin kinase activity
A4V04_RS00830	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A4V04_RS00835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4V04_RS00835	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A4V04_RS00845	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A4V04_RS00850	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A4V04_RS00860	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A4V04_RS00865	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A4V04_RS00875	COG0358	DNA primase activity
A4V04_RS00900	COG1227	inorganic diphosphatase activity
A4V04_RS00915	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4V04_RS00915	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A4V04_RS00925	COG2840	Smr protein MutS2
A4V04_RS00930	COG0492	ferredoxin-NADP+ reductase activity
A4V04_RS00935	COG1674	ftsk spoiiie
A4V04_RS00970	COG0802	atpase or kinase
A4V04_RS00975	COG0860	N-Acetylmuramoyl-L-alanine amidase
A4V04_RS00985	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A4V04_RS01010	COG1704	LemA family
A4V04_RS01015	COG0778	Nitroreductase
A4V04_RS01025	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A4V04_RS01035	COG1187	pseudouridine synthase activity
A4V04_RS01040	COG0009	L-threonylcarbamoyladenylate synthase
A4V04_RS01045	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A4V04_RS01050	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A4V04_RS01055	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A4V04_RS01070	COG0352	thiamine-phosphate diphosphorylase activity
A4V04_RS01075	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A4V04_RS01080	COG0730	response to heat
A4V04_RS01105	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
A4V04_RS01125	COG2925	Exonuclease
A4V04_RS01130	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A4V04_RS01150	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A4V04_RS01155	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A4V04_RS01160	COG0735	belongs to the Fur family
A4V04_RS01170	COG0497	DNA recombination
A4V04_RS01175	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A4V04_RS01195	COG1388	LysM domain
A4V04_RS01195	COG0741	lytic transglycosylase activity
A4V04_RS01200	COG2226	methyltransferase
A4V04_RS01205	COG0328	RNA-DNA hybrid ribonuclease activity
A4V04_RS01215	COG3069	C4-dicarboxylate transmembrane transporter activity
A4V04_RS01230	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4V04_RS01285	COG1132	(ABC) transporter
A4V04_RS01290	COG0471	metal ion transport
A4V04_RS01325	COG1215	transferase activity, transferring glycosyl groups
A4V04_RS01355	COG2184	nucleotidyltransferase activity
A4V04_RS01380	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A4V04_RS01470	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A4V04_RS01480	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4V04_RS01485	COG0287	Prephenate dehydrogenase
A4V04_RS01495	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A4V04_RS01505	COG0776	regulation of translation
A4V04_RS01520	COG0165	Argininosuccinate lyase
A4V04_RS01525	COG2095	MarC family integral membrane protein
A4V04_RS01530	COG1233	COG1233 Phytoene dehydrogenase and related
A4V04_RS01535	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4V04_RS01555	COG1053	succinate dehydrogenase
A4V04_RS01580	COG0114	fumarate hydratase activity
A4V04_RS01585	COG1027	Aspartate ammonia-lyase
A4V04_RS01590	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4V04_RS01595	COG0583	DNA-binding transcription factor activity
A4V04_RS01600	COG0697	spore germination
A4V04_RS01605	COG1027	Aspartate ammonia-lyase
A4V04_RS01610	COG1027	Aspartate ammonia-lyase
A4V04_RS01620	COG0583	DNA-binding transcription factor activity
A4V04_RS01625	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4V04_RS01640	COG0165	Argininosuccinate lyase
A4V04_RS01645	COG0114	fumarate hydratase activity
A4V04_RS01660	COG1373	ATPase (AAA superfamily
A4V04_RS01665	COG0243	molybdopterin cofactor binding
A4V04_RS01670	COG0437	4 iron, 4 sulfur cluster binding
A4V04_RS01700	COG2801	Transposase and inactivated derivatives
A4V04_RS01715	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A4V04_RS01725	COG3069	C4-dicarboxylate transmembrane transporter activity
A4V04_RS01730	COG1598	PFAM Uncharacterised protein family UPF0150
A4V04_RS01905	COG1215	transferase activity, transferring glycosyl groups
A4V04_RS01910	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A4V04_RS01915	COG0438	transferase activity, transferring glycosyl groups
A4V04_RS01920	COG1216	Glycosyl transferase, family 2
A4V04_RS01965	COG4566	intracellular signal transduction
A4V04_RS01975	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4V04_RS02055	COG2357	RelA SpoT domain protein
A4V04_RS02105	COG1027	Aspartate ammonia-lyase
A4V04_RS02110	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4V04_RS02130	COG4566	intracellular signal transduction
A4V04_RS02140	COG0431	NADPH-dependent FMN reductase
A4V04_RS02140	COG1053	succinate dehydrogenase
A4V04_RS02140	COG3976	FMN-binding domain protein
A4V04_RS02155	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A4V04_RS02155	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A4V04_RS02190	COG0583	DNA-binding transcription factor activity
A4V04_RS02205	COG1053	succinate dehydrogenase
A4V04_RS02250	COG0697	spore germination
A4V04_RS02260	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4V04_RS02265	COG0583	DNA-binding transcription factor activity
A4V04_RS02280	COG1053	succinate dehydrogenase
A4V04_RS02305	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4V04_RS02325	COG3976	FMN-binding domain protein
A4V04_RS02325	COG1053	succinate dehydrogenase
A4V04_RS02330	COG1053	succinate dehydrogenase
A4V04_RS02335	COG4566	intracellular signal transduction
A4V04_RS02340	COG4191	Histidine kinase
A4V04_RS02360	COG1053	succinate dehydrogenase
A4V04_RS02365	COG1053	succinate dehydrogenase
A4V04_RS02365	COG3976	FMN-binding domain protein
A4V04_RS02380	COG0583	DNA-binding transcription factor activity
A4V04_RS02385	COG1053	succinate dehydrogenase
A4V04_RS02395	COG3976	FMN-binding domain protein
A4V04_RS02395	COG1053	succinate dehydrogenase
A4V04_RS02405	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4V04_RS02415	COG0165	Argininosuccinate lyase
A4V04_RS02460	COG0583	DNA-binding transcription factor activity
A4V04_RS02475	COG0527	aspartate kinase activity
A4V04_RS02485	COG0537	adenosine 5'-monophosphoramidase activity
A4V04_RS02495	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4V04_RS02505	COG3069	C4-dicarboxylate transmembrane transporter activity
A4V04_RS02510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4V04_RS02530	COG1473	amidohydrolase
A4V04_RS02545	COG4974	Belongs to the 'phage' integrase family
A4V04_RS02570	COG3328	transposase activity
A4V04_RS02625	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4V04_RS02635	COG2205	protein histidine kinase activity
A4V04_RS02635	COG3850	Histidine kinase
A4V04_RS02635	COG4999	Histidine kinase
A4V04_RS02635	COG3437	response regulator, receiver
A4V04_RS02645	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
A4V04_RS02655	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A4V04_RS02655	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
A4V04_RS02660	COG1643	Atp-dependent helicase
A4V04_RS02665	COG1686	Belongs to the peptidase S11 family
A4V04_RS02685	COG2251	uridine kinase activity
A4V04_RS02685	COG0195	Participates in both transcription termination and antitermination
A4V04_RS02690	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A4V04_RS02695	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A4V04_RS02770	COG1530	ribonuclease E activity
A4V04_RS02780	COG0546	phosphoglycolate phosphatase activity
A4V04_RS02790	COG0424	maF-like protein
A4V04_RS02840	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A4V04_RS02845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A4V04_RS02850	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A4V04_RS02855	COG1028	Short-chain dehydrogenase reductase Sdr
A4V04_RS02860	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A4V04_RS02865	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A4V04_RS02880	COG0571	ribonuclease III activity
A4V04_RS02885	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A4V04_RS02890	COG1381	Involved in DNA repair and RecF pathway recombination
A4V04_RS02900	COG0736	holo-[acyl-carrier-protein] synthase activity
A4V04_RS02905	COG1472	Belongs to the glycosyl hydrolase 3 family
A4V04_RS02940	COG0583	DNA-binding transcription factor activity
A4V04_RS02945	COG3976	FMN-binding domain protein
A4V04_RS02945	COG1053	succinate dehydrogenase
A4V04_RS02945	COG0431	NADPH-dependent FMN reductase
A4V04_RS02950	COG0567	Dehydrogenase, E1 component
A4V04_RS02955	COG0508	dehydrogenase complex catalyzes the overall conversion of
A4V04_RS02960	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A4V04_RS02970	COG1199	ATP-dependent helicase activity
A4V04_RS02985	COG0564	pseudouridine synthase activity
A4V04_RS03005	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V04_RS03030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V04_RS03050	COG0187	DNA topoisomerase II activity
A4V04_RS03060	COG3976	FMN-binding domain protein
A4V04_RS03060	COG1053	succinate dehydrogenase
A4V04_RS03060	COG0431	NADPH-dependent FMN reductase
A4V04_RS03080	COG2321	neutral zinc metallopeptidase
A4V04_RS03090	COG1053	succinate dehydrogenase
A4V04_RS03105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A4V04_RS03110	COG0326	Molecular chaperone. Has ATPase activity
A4V04_RS03120	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A4V04_RS03135	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
A4V04_RS03140	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A4V04_RS03160	COG0047	phosphoribosylformylglycinamidine synthase activity
A4V04_RS03165	COG0504	CTP synthase activity
A4V04_RS03170	COG2877	3-deoxy-8-phosphooctulonate synthase activity
A4V04_RS03175	COG0148	phosphopyruvate hydratase activity
A4V04_RS03180	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
A4V04_RS03185	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A4V04_RS03200	COG0613	PHP domain protein
A4V04_RS03205	COG0009	L-threonylcarbamoyladenylate synthase
A4V04_RS03210	COG1994	Peptidase M50
A4V04_RS03220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A4V04_RS03225	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
A4V04_RS03230	COG1047	Peptidyl-prolyl cis-trans
A4V04_RS03235	COG1966	Carbon starvation protein
A4V04_RS03255	COG1473	amidohydrolase
A4V04_RS03260	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A4V04_RS03265	COG0483	inositol monophosphate 1-phosphatase activity
A4V04_RS03275	COG1045	serine acetyltransferase
A4V04_RS03280	COG1022	Amp-dependent synthetase and ligase
A4V04_RS03285	COG1022	Amp-dependent synthetase and ligase
A4V04_RS03325	COG1757	Na H antiporter
A4V04_RS03330	COG0322	excinuclease ABC activity
A4V04_RS03335	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A4V04_RS03375	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4V04_RS03380	COG0390	transport system, permease component
A4V04_RS03400	COG1253	flavin adenine dinucleotide binding
A4V04_RS03415	COG0252	asparaginase activity
A4V04_RS03420	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A4V04_RS03435	COG3328	transposase activity
A4V04_RS03445	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4V04_RS03450	COG0066	3-isopropylmalate dehydratase activity
A4V04_RS03455	COG0473	3-isopropylmalate dehydrogenase activity
A4V04_RS03465	COG0101	tRNA pseudouridine synthase activity
A4V04_RS03470	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A4V04_RS03475	COG0285	dihydrofolate synthase activity
A4V04_RS03495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V04_RS03520	COG1053	succinate dehydrogenase
A4V04_RS03520	COG3976	FMN-binding domain protein
A4V04_RS03535	COG0179	Fumarylacetoacetate (FAA) hydrolase
A4V04_RS03540	COG2951	lytic endotransglycosylase activity
A4V04_RS03545	COG0123	including yeast histone deacetylase and acetoin utilization protein
A4V04_RS03550	COG0338	D12 class N6 adenine-specific DNA methyltransferase
A4V04_RS03570	COG1238	metal cluster binding
A4V04_RS03585	COG0228	four-way junction DNA binding
A4V04_RS03590	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A4V04_RS03595	COG0336	Belongs to the RNA methyltransferase TrmD family
A4V04_RS03600	COG0335	large ribosomal subunit rRNA binding
A4V04_RS03620	COG1162	GTPase activity
A4V04_RS03625	COG0501	Belongs to the peptidase M48B family
A4V04_RS03630	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
A4V04_RS03635	COG2084	Dehydrogenase
A4V04_RS03645	COG0628	permease
A4V04_RS03650	COG1733	regulation of RNA biosynthetic process
A4V04_RS03675	COG1053	succinate dehydrogenase
A4V04_RS03685	COG1013	pyruvate-flavodoxin oxidoreductase activity
A4V04_RS03690	COG0674	pyruvate-flavodoxin oxidoreductase activity
A4V04_RS03715	COG1216	Glycosyl transferase, family 2
A4V04_RS03745	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A4V04_RS03770	COG3152	Membrane
A4V04_RS03780	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4V04_RS03800	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
A4V04_RS03815	COG0688	phosphatidylethanolamine metabolic process
A4V04_RS03820	COG1183	phosphatidylcholine synthase activity
A4V04_RS03830	COG2801	Transposase and inactivated derivatives
A4V04_RS03835	COG2801	Transposase and inactivated derivatives
A4V04_RS03845	COG2194	sulfuric ester hydrolase activity
A4V04_RS03850	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A4V04_RS03855	COG1185	polyribonucleotide nucleotidyltransferase activity
A4V04_RS03860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A4V04_RS03865	COG0149	triose-phosphate isomerase activity
A4V04_RS03885	COG0454	-acetyltransferase
A4V04_RS03910	COG0477	Major facilitator Superfamily
A4V04_RS03940	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A4V04_RS03965	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4V04_RS03965	COG4651	solute:proton antiporter activity
A4V04_RS03970	COG4651	solute:proton antiporter activity
A4V04_RS03970	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A4V04_RS03975	COG0437	4 iron, 4 sulfur cluster binding
A4V04_RS03980	COG0243	molybdopterin cofactor binding
A4V04_RS03990	COG1414	Transcriptional regulator
A4V04_RS04005	COG0167	dihydroorotate dehydrogenase activity
A4V04_RS04010	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A4V04_RS04015	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A4V04_RS04035	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4V04_RS04040	COG2801	Transposase and inactivated derivatives
A4V04_RS04045	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A4V04_RS04080	COG3344	reverse transcriptase
A4V04_RS04135	COG1272	protein, Hemolysin III
A4V04_RS04150	COG3976	FMN-binding domain protein
A4V04_RS04150	COG1053	succinate dehydrogenase
A4V04_RS04180	COG0583	DNA-binding transcription factor activity
A4V04_RS04190	COG0004	ammonium transporteR
A4V04_RS04200	COG1464	Belongs to the NlpA lipoprotein family
A4V04_RS04215	COG1053	succinate dehydrogenase
A4V04_RS04220	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A4V04_RS04230	COG1027	Aspartate ammonia-lyase
A4V04_RS04235	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4V04_RS04240	COG1027	Aspartate ammonia-lyase
A4V04_RS04255	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4V04_RS04260	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A4V04_RS04260	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A4V04_RS04295	COG0786	glutamate:sodium symporter activity
A4V04_RS04305	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A4V04_RS04310	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A4V04_RS04315	COG0252	asparaginase activity
A4V04_RS04340	COG0129	dihydroxy-acid dehydratase activity
A4V04_RS04345	COG0791	NLP P60 protein
A4V04_RS04355	COG3366	ferrous iron transmembrane transporter activity
A4V04_RS04360	COG0700	Nucleoside recognition
A4V04_RS04365	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A4V04_RS04375	COG0697	spore germination
A4V04_RS04385	COG1301	dicarboxylic acid transport
A4V04_RS04395	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A4V04_RS04415	COG0243	molybdopterin cofactor binding
A4V04_RS04415	COG3383	formate dehydrogenase (NAD+) activity
A4V04_RS04420	COG3064	Membrane
A4V04_RS04420	COG0437	4 iron, 4 sulfur cluster binding
A4V04_RS04430	COG2223	nitrite transmembrane transporter activity
A4V04_RS04435	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A4V04_RS04470	COG0589	response to stress
A4V04_RS04475	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A4V04_RS04485	COG0789	Transcriptional regulator
A4V04_RS04515	COG3118	belongs to the thioredoxin family
A4V04_RS04550	COG2188	Transcriptional regulator
A4V04_RS04555	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A4V04_RS04560	COG0583	DNA-binding transcription factor activity
A4V04_RS04565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A4V04_RS04570	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A4V04_RS04580	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A4V04_RS04585	COG2801	Transposase and inactivated derivatives
A4V04_RS04605	COG2962	Rard protein
A4V04_RS04620	COG0277	FAD linked oxidase domain protein
A4V04_RS04625	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4V04_RS04630	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4V04_RS04640	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A4V04_RS04645	COG0583	DNA-binding transcription factor activity
A4V04_RS04655	COG1131	(ABC) transporter
A4V04_RS04660	COG0842	Transport permease protein
A4V04_RS04665	COG0842	Transport permease protein
A4V04_RS04670	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A4V04_RS04680	COG1380	Effector of murein hydrolase LrgA
A4V04_RS04685	COG1346	cytolysis
A4V04_RS04695	COG0583	DNA-binding transcription factor activity
A4V04_RS04715	COG0525	valine-tRNA ligase activity
A4V04_RS04725	COG4191	Histidine kinase
A4V04_RS04730	COG0492	ferredoxin-NADP+ reductase activity
A4V04_RS04770	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A4V04_RS04775	COG1473	amidohydrolase
A4V04_RS04780	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A4V04_RS04790	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A4V04_RS04805	COG1280	lysine exporter protein (LysE YggA)
A4V04_RS04810	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A4V04_RS04815	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A4V04_RS04820	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A4V04_RS04845	COG1752	Esterase of the alpha-beta hydrolase superfamily
A4V04_RS04850	COG2116	formate transmembrane transporter activity
A4V04_RS04860	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
A4V04_RS04875	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4V04_RS04875	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A4V04_RS04890	COG0210	DNA helicase
A4V04_RS04895	COG0495	leucyl-tRNA aminoacylation
A4V04_RS04910	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A4V04_RS04920	COG1473	amidohydrolase
A4V04_RS04925	COG1053	succinate dehydrogenase
A4V04_RS04950	COG0471	metal ion transport
A4V04_RS04970	COG0733	neurotransmitter:sodium symporter activity
A4V04_RS04975	COG0733	neurotransmitter:sodium symporter activity
A4V04_RS04990	COG1760	l-serine dehydratase
A4V04_RS04995	COG1295	ribonuclease BN
A4V04_RS05025	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A4V04_RS05030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A4V04_RS05035	COG0740	serine-type endopeptidase activity
A4V04_RS05040	COG0544	peptidyl-prolyl cis-trans isomerase activity
A4V04_RS05050	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A4V04_RS05055	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A4V04_RS05060	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A4V04_RS05065	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
A4V04_RS05075	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
A4V04_RS05075	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
A4V04_RS05090	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A4V04_RS05100	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A4V04_RS05105	COG0697	spore germination
A4V04_RS05125	COG0494	nUDIX hydrolase
A4V04_RS05135	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
A4V04_RS05145	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A4V04_RS05150	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A4V04_RS05165	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A4V04_RS05170	COG1918	ferrous iron import across plasma membrane
A4V04_RS05200	COG0612	Peptidase, M16
A4V04_RS05205	COG2917	probably involved in intracellular septation
A4V04_RS05210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4V04_RS05240	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4V04_RS05275	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A4V04_RS05285	COG0728	peptidoglycan biosynthetic process
A4V04_RS05290	COG0268	Binds directly to 16S ribosomal RNA
A4V04_RS05295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A4V04_RS05300	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A4V04_RS05305	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A4V04_RS05310	COG0142	geranyltranstransferase activity
A4V04_RS05315	COG1722	exodeoxyribonuclease VII activity
A4V04_RS05340	COG0745	RESPONSE REGULATOR receiver
A4V04_RS05340	COG4191	Histidine kinase
A4V04_RS05340	COG2205	protein histidine kinase activity
A4V04_RS05350	COG1053	succinate dehydrogenase
A4V04_RS05355	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A4V04_RS05355	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A4V04_RS05360	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A4V04_RS05380	COG1214	PFAM Peptidase M22, glycoprotease
A4V04_RS05395	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A4V04_RS05400	COG0560	Phosphoserine phosphatase
A4V04_RS05425	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
A4V04_RS05425	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
A4V04_RS05445	COG1053	succinate dehydrogenase
A4V04_RS05585	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A4V04_RS05590	COG4191	Histidine kinase
A4V04_RS05595	COG4566	intracellular signal transduction
A4V04_RS05600	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A4V04_RS05615	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A4V04_RS05625	COG3852	Histidine kinase
A4V04_RS05630	COG0174	glutamine synthetase
A4V04_RS05635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4V04_RS05640	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A4V04_RS05645	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
A4V04_RS05650	COG1561	YicC-like family, N-terminal region
A4V04_RS05695	COG0586	Pfam SNARE associated Golgi protein
A4V04_RS05700	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A4V04_RS05705	COG0440	acetolactate synthase activity
A4V04_RS05710	COG0028	Belongs to the TPP enzyme family
A4V04_RS05715	COG2205	protein histidine kinase activity
A4V04_RS05715	COG0745	RESPONSE REGULATOR receiver
A4V04_RS05715	COG4191	Histidine kinase
A4V04_RS05720	COG1619	proteins homologs of microcin C7 resistance protein MccF
A4V04_RS05725	COG0590	tRNA wobble adenosine to inosine editing
A4V04_RS05730	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A4V04_RS05740	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A4V04_RS05740	COG0519	Catalyzes the synthesis of GMP from XMP
A4V04_RS05745	COG0517	IMP dehydrogenase activity
A4V04_RS05745	COG0516	GMP reductase activity
A4V04_RS05755	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A4V04_RS05760	COG1979	alcohol dehydrogenase
A4V04_RS05785	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A4V04_RS05790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4V04_RS05795	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A4V04_RS05800	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4V04_RS05810	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A4V04_RS05815	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4V04_RS05820	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
A4V04_RS05835	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A4V04_RS05840	COG0575	Belongs to the CDS family
A4V04_RS05845	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A4V04_RS05850	COG0233	cytoplasmic translational termination
A4V04_RS05860	COG0528	UMP kinase activity
A4V04_RS05865	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A4V04_RS05870	COG0052	Belongs to the universal ribosomal protein uS2 family
A4V04_RS05875	COG0024	Methionine aminopeptidase
A4V04_RS05880	COG0679	Auxin Efflux Carrier
A4V04_RS05890	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
A4V04_RS05900	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A4V04_RS05910	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A4V04_RS05915	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A4V04_RS05920	COG2171	N-acyltransferase activity
A4V04_RS05925	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4V04_RS05930	COG2890	protein-(glutamine-N5) methyltransferase activity
A4V04_RS05935	COG0488	(ABC) transporter
A4V04_RS05975	COG3976	FMN-binding domain protein
A4V04_RS05975	COG1053	succinate dehydrogenase
A4V04_RS05980	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A4V04_RS06005	COG2217	Heavy metal translocating P-type atpase
A4V04_RS06015	COG0433	COG0433 Predicted ATPase
A4V04_RS06025	COG1966	Carbon starvation protein
A4V04_RS06065	COG0746	molybdenum cofactor guanylyltransferase activity
A4V04_RS06070	COG0303	'Molybdopterin
A4V04_RS06075	COG2129	metallophosphoesterase
A4V04_RS06080	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A4V04_RS06085	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A4V04_RS06090	COG0402	S-adenosylhomocysteine deaminase activity
A4V04_RS06110	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A4V04_RS06125	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4V04_RS06260	COG3736	Type IV secretory pathway, component VirB8
A4V04_RS06270	COG2337	Toxic component of a toxin-antitoxin (TA) module
A4V04_RS06290	COG3077	Addiction module antitoxin, RelB DinJ family
A4V04_RS06365	COG3041	Addiction module toxin RelE StbE family
A4V04_RS06470	COG1192	Involved in chromosome partitioning
A4V04_RS06475	COG1475	DNA binding
A4V04_RS06505	COG2026	Addiction module toxin, RelE StbE family
A4V04_RS06545	COG4974	Belongs to the 'phage' integrase family
A4V04_RS06590	COG3681	Belongs to the UPF0597 family
A4V04_RS06600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4V04_RS06605	COG0765	amino acid transport
A4V04_RS06620	COG4120	Belongs to the binding-protein-dependent transport system permease family
A4V04_RS06625	COG1122	ATPase activity
A4V04_RS06630	COG0037	tRNA processing
A4V04_RS06645	COG0215	cysteine-tRNA ligase activity
A4V04_RS06655	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4V04_RS06660	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A4V04_RS06665	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A4V04_RS06670	COG0084	hydrolase, TatD family'
A4V04_RS06680	COG0826	peptidase U32
A4V04_RS06695	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A4V04_RS06705	COG3088	subunit of a heme lyase
A4V04_RS06710	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V04_RS06720	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
A4V04_RS06730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4V04_RS06735	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A4V04_RS06740	COG4133	protoheme IX ABC transporter activity
A4V04_RS06760	COG3093	addiction module antidote protein HigA
A4V04_RS06765	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A4V04_RS06775	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V04_RS06800	COG0375	protein maturation
A4V04_RS06810	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A4V04_RS06820	COG0409	Hydrogenase expression formation protein
A4V04_RS06845	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4V04_RS06850	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A4V04_RS06855	COG1862	Preprotein translocase
A4V04_RS06860	COG0343	queuine tRNA-ribosyltransferase activity
A4V04_RS06865	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A4V04_RS06875	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A4V04_RS06885	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
A4V04_RS06890	COG1534	Rna-binding protein
A4V04_RS06895	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A4V04_RS06900	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A4V04_RS06905	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A4V04_RS06910	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A4V04_RS06915	COG0505	Belongs to the CarA family
A4V04_RS06925	COG0194	GDP metabolic process
A4V04_RS06930	COG1758	RNA polymerase activity
A4V04_RS06935	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A4V04_RS06940	COG3111	PFAM Bacterial OB fold (BOF) protein
A4V04_RS06950	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4V04_RS06965	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A4V04_RS06985	COG2814	Major facilitator Superfamily
A4V04_RS06995	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A4V04_RS07000	COG0254	rRNA binding
A4V04_RS07010	COG0534	Mate efflux family protein
A4V04_RS07015	COG4187	Peptidase family M20/M25/M40
A4V04_RS07045	COG3069	C4-dicarboxylate transmembrane transporter activity
A4V04_RS07050	COG0501	Belongs to the peptidase M48B family
A4V04_RS07055	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
A4V04_RS07090	COG3344	reverse transcriptase
A4V04_RS07105	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A4V04_RS07110	COG0582	viral genome integration into host DNA
A4V04_RS07115	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A4V04_RS07125	COG1053	succinate dehydrogenase
A4V04_RS07130	COG0745	RESPONSE REGULATOR receiver
A4V04_RS07135	COG5002	protein histidine kinase activity
A4V04_RS07140	COG0165	Argininosuccinate lyase
A4V04_RS07145	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A4V04_RS07150	COG0312	modulator of DNA gyrase
A4V04_RS07155	COG3028	Belongs to the UPF0307 family
A4V04_RS07160	COG0521	Mo-molybdopterin cofactor biosynthetic process
A4V04_RS07170	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A4V04_RS07175	COG0513	Belongs to the DEAD box helicase family
A4V04_RS07200	COG3976	FMN-binding domain protein
A4V04_RS07200	COG1053	succinate dehydrogenase
A4V04_RS07205	COG0419	ATPase involved in DNA repair
A4V04_RS07210	COG0420	3'-5' exonuclease activity
A4V04_RS07215	COG0675	Transposase, IS605 OrfB family
A4V04_RS07240	COG0471	metal ion transport
A4V04_RS07245	COG0159	tryptophan synthase activity
A4V04_RS07250	COG0133	tryptophan synthase activity
A4V04_RS07270	COG0436	Aminotransferase
A4V04_RS07275	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
A4V04_RS07290	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A4V04_RS07295	COG0305	Participates in initiation and elongation during chromosome replication
A4V04_RS07305	COG0243	molybdopterin cofactor binding
A4V04_RS07310	COG0437	4 iron, 4 sulfur cluster binding
A4V04_RS07320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4V04_RS07335	COG0359	binds to the 23S rRNA
A4V04_RS07340	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A4V04_RS07350	COG0360	Binds together with S18 to 16S ribosomal RNA
A4V04_RS07355	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A4V04_RS07360	COG0557	exoribonuclease II activity
A4V04_RS07370	COG0791	NLP P60 protein
A4V04_RS07375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A4V04_RS07385	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
A4V04_RS07390	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
A4V04_RS07400	COG0765	amino acid transport
A4V04_RS07415	COG0431	NADPH-dependent FMN reductase
A4V04_RS07415	COG3976	FMN-binding domain protein
A4V04_RS07415	COG0431	NADPH-dependent FMN reductase
A4V04_RS07415	COG1053	succinate dehydrogenase
A4V04_RS07415	COG1053	succinate dehydrogenase
A4V04_RS07415	COG3976	FMN-binding domain protein
A4V04_RS07425	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
A4V04_RS07430	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
A4V04_RS07440	COG0617	tRNA 3'-terminal CCA addition
A4V04_RS07465	COG0493	'glutamate synthase
A4V04_RS07485	COG0437	4 iron, 4 sulfur cluster binding
A4V04_RS07490	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A4V04_RS07495	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A4V04_RS07510	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A4V04_RS07515	COG1115	amino acid carrier protein
A4V04_RS07535	COG2814	Major facilitator Superfamily
A4V04_RS07545	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
A4V04_RS07550	COG0586	Pfam SNARE associated Golgi protein
A4V04_RS07560	COG0126	phosphoglycerate kinase activity
A4V04_RS07565	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A4V04_RS07570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A4V04_RS07575	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A4V04_RS07580	COG0741	lytic transglycosylase activity
A4V04_RS07605	COG0745	RESPONSE REGULATOR receiver
A4V04_RS07610	COG5002	protein histidine kinase activity
A4V04_RS07615	COG1053	succinate dehydrogenase
A4V04_RS07625	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A4V04_RS07635	COG3585	molybdate ion transport
A4V04_RS07640	COG2239	Acts as a magnesium transporter
A4V04_RS07645	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A4V04_RS07655	COG3150	esterase
A4V04_RS07660	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4V04_RS07670	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A4V04_RS07675	COG0511	ligase activity, forming carbon-carbon bonds
A4V04_RS07680	COG0439	Biotin carboxylase
A4V04_RS07685	COG2264	protein methyltransferase activity
A4V04_RS07695	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A4V04_RS07725	COG0308	aminopeptidase N
A4V04_RS07730	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A4V04_RS07740	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A4V04_RS07750	COG1473	amidohydrolase
A4V04_RS07755	COG3069	C4-dicarboxylate transmembrane transporter activity
A4V04_RS07765	COG3850	Histidine kinase
A4V04_RS07770	COG2197	response regulator
A4V04_RS07780	COG0348	domain, Protein
A4V04_RS07785	COG0437	4 iron, 4 sulfur cluster binding
A4V04_RS07790	COG0243	molybdopterin cofactor binding
A4V04_RS07810	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4V04_RS07815	COG1691	(AIR) carboxylase
A4V04_RS07820	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
A4V04_RS07830	COG4566	intracellular signal transduction
A4V04_RS07835	COG4191	Histidine kinase
A4V04_RS07835	COG2205	protein histidine kinase activity
A4V04_RS07835	COG0745	RESPONSE REGULATOR receiver
A4V04_RS07840	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V04_RS07865	COG3301	Polysulphide reductase, NrfD
A4V04_RS07870	COG0437	4 iron, 4 sulfur cluster binding
A4V04_RS07875	COG0545	Peptidyl-prolyl cis-trans isomerase
A4V04_RS07885	COG0484	heat shock protein binding
A4V04_RS07895	COG3875	lactate racemase activity
A4V04_RS07900	COG0217	transcriptional regulatory protein
A4V04_RS07905	COG0151	Belongs to the GarS family
A4V04_RS07915	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A4V04_RS07925	COG0437	4 iron, 4 sulfur cluster binding
A4V04_RS07930	COG0243	molybdopterin cofactor binding
A4V04_RS07950	COG0243	molybdopterin cofactor binding
A4V04_RS07965	COG1408	metallophosphoesterase
A4V04_RS07970	COG0799	negative regulation of ribosome biogenesis
A4V04_RS07995	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
A4V04_RS08005	COG0513	Belongs to the DEAD box helicase family
A4V04_RS08020	COG0006	proline dipeptidase activity
A4V04_RS08025	COG2855	membrane
A4V04_RS08035	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A4V04_RS08055	COG0564	pseudouridine synthase activity
A4V04_RS08070	COG0443	Heat shock 70 kDa protein
A4V04_RS08075	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A4V04_RS08090	COG2194	sulfuric ester hydrolase activity
A4V04_RS08095	COG0745	RESPONSE REGULATOR receiver
A4V04_RS08100	COG3850	Histidine kinase
A4V04_RS08100	COG5002	protein histidine kinase activity
A4V04_RS08105	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A4V04_RS08120	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
A4V04_RS08130	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
A4V04_RS08135	COG0312	modulator of DNA gyrase
A4V04_RS08145	COG0494	nUDIX hydrolase
A4V04_RS08165	COG1053	succinate dehydrogenase
A4V04_RS08185	COG3328	transposase activity
A4V04_RS08195	COG0431	NADPH-dependent FMN reductase
A4V04_RS08195	COG1053	succinate dehydrogenase
A4V04_RS08195	COG3976	FMN-binding domain protein
A4V04_RS08205	COG4589	Belongs to the CDS family
A4V04_RS08215	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
A4V04_RS08225	COG1538	Outer membrane efflux protein
A4V04_RS08240	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A4V04_RS08245	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A4V04_RS08255	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4V04_RS08295	COG0795	lipopolysaccharide-transporting ATPase activity
A4V04_RS08305	COG4608	Belongs to the ABC transporter superfamily
A4V04_RS08310	COG0444	Belongs to the ABC transporter superfamily
A4V04_RS08315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4V04_RS08320	COG1473	amidohydrolase
A4V04_RS08325	COG0601	transmembrane transport
A4V04_RS08330	COG0747	negative chemotaxis
A4V04_RS08370	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A4V04_RS08375	COG0546	phosphoglycolate phosphatase activity
A4V04_RS08380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A4V04_RS08385	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
A4V04_RS08390	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
A4V04_RS08405	COG2119	membrane
A4V04_RS08420	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A4V04_RS08425	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A4V04_RS08445	COG2969	positive regulation of protein catabolic process
A4V04_RS08450	COG0625	glutathione transferase activity
A4V04_RS08455	COG1970	mechanosensitive ion channel activity
A4V04_RS08465	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A4V04_RS08480	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
A4V04_RS08485	COG0589	response to stress
A4V04_RS08495	COG2197	response regulator
A4V04_RS08500	COG0315	cyclic pyranopterin monophosphate synthase activity
A4V04_RS08505	COG4783	chaperone-mediated protein folding
A4V04_RS08510	COG0492	ferredoxin-NADP+ reductase activity
A4V04_RS08520	COG0489	protein tyrosine kinase activity
A4V04_RS08530	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V04_RS08530	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A4V04_RS08535	COG0659	secondary active sulfate transmembrane transporter activity
A4V04_RS08540	COG0281	malic enzyme
A4V04_RS08555	COG2885	chlorophyll binding
A4V04_RS08560	COG0823	Involved in the tonB-independent uptake of proteins
A4V04_RS08570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A4V04_RS08590	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A4V04_RS08595	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A4V04_RS08610	COG0751	glycine-tRNA ligase activity
A4V04_RS08615	COG0752	glycyl-tRNA synthetase alpha subunit
A4V04_RS08620	COG0154	amidase activity
A4V04_RS08625	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A4V04_RS08630	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A4V04_RS08635	COG4535	Mg2 and Co2 transporter CorC
A4V04_RS08640	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A4V04_RS08645	COG1702	phosphate starvation-inducible protein PhoH
A4V04_RS08650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A4V04_RS08655	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A4V04_RS08665	COG3976	FMN-binding domain protein
A4V04_RS08665	COG1053	succinate dehydrogenase
A4V04_RS08670	COG2986	histidine ammonia-lyase
A4V04_RS08680	COG0351	phosphomethylpyrimidine kinase
A4V04_RS08705	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A4V04_RS08710	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A4V04_RS08715	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A4V04_RS08720	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A4V04_RS08735	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A4V04_RS08740	COG1678	Uncharacterized ACR, COG1678
A4V04_RS08770	COG3069	C4-dicarboxylate transmembrane transporter activity
A4V04_RS08775	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4V04_RS08785	COG0165	Argininosuccinate lyase
A4V04_RS08790	COG2223	nitrite transmembrane transporter activity
A4V04_RS08795	COG1280	lysine exporter protein (LysE YggA)
A4V04_RS08800	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A4V04_RS08800	COG0047	phosphoribosylformylglycinamidine synthase activity
A4V04_RS08810	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A4V04_RS08815	COG0629	single-stranded DNA binding
A4V04_RS08820	COG0697	spore germination
A4V04_RS08830	COG1053	succinate dehydrogenase
A4V04_RS08840	COG4191	Histidine kinase
A4V04_RS08850	COG1136	(ABC) transporter
A4V04_RS08850	COG0577	efflux transmembrane transporter activity
A4V04_RS08855	COG1136	(ABC) transporter
A4V04_RS08855	COG0577	efflux transmembrane transporter activity
A4V04_RS08870	COG0483	inositol monophosphate 1-phosphatase activity
A4V04_RS08875	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A4V04_RS08885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A4V04_RS08905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A4V04_RS08905	COG1042	CoA-binding domain protein
A4V04_RS08905	COG0045	succinate-CoA ligase (ADP-forming) activity
A4V04_RS08915	COG3976	FMN-binding domain protein
A4V04_RS08915	COG1053	succinate dehydrogenase
A4V04_RS08920	COG1053	succinate dehydrogenase
A4V04_RS08920	COG3976	FMN-binding domain protein
A4V04_RS08925	COG4566	intracellular signal transduction
A4V04_RS08935	COG1024	Enoyl-CoA hydratase
A4V04_RS08945	COG1126	abc transporter atp-binding protein
A4V04_RS08955	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
A4V04_RS08970	COG1137	ATPase activity
A4V04_RS08975	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A4V04_RS08985	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A4V04_RS08995	COG1660	Displays ATPase and GTPase activities
A4V04_RS09000	COG1194	a g-specific adenine glycosylase
A4V04_RS09005	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A4V04_RS09010	COG2233	PERMEase
A4V04_RS09015	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A4V04_RS09020	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A4V04_RS09025	COG1160	GTP binding
A4V04_RS09040	COG4624	Iron only hydrogenase large subunit, C-terminal domain
A4V04_RS09040	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4V04_RS09045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A4V04_RS09050	COG1022	Amp-dependent synthetase and ligase
A4V04_RS09060	COG0488	(ABC) transporter
A4V04_RS09070	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A4V04_RS09075	COG2326	polyphosphate kinase activity
A4V04_RS09085	COG2205	protein histidine kinase activity
A4V04_RS09100	COG3976	FMN-binding domain protein
A4V04_RS09100	COG1053	succinate dehydrogenase
A4V04_RS09130	COG3328	transposase activity
A4V04_RS09140	COG3301	Polysulphide reductase, NrfD
A4V04_RS09145	COG0437	4 iron, 4 sulfur cluster binding
A4V04_RS09150	COG0484	heat shock protein binding
A4V04_RS09160	COG2414	aldehyde ferredoxin oxidoreductase
A4V04_RS09165	COG0437	4 iron, 4 sulfur cluster binding
A4V04_RS09175	COG3976	FMN-binding domain protein
A4V04_RS09175	COG1053	succinate dehydrogenase
A4V04_RS09180	COG4566	intracellular signal transduction
A4V04_RS09185	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A4V04_RS09190	COG4191	Histidine kinase
A4V04_RS09205	COG0037	tRNA processing
A4V04_RS09245	COG1473	amidohydrolase
A4V04_RS09250	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A4V04_RS09255	COG1560	Kdo2-lipid A biosynthetic process
A4V04_RS09260	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A4V04_RS09270	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A4V04_RS09280	COG0523	cobalamin synthesis protein
A4V04_RS09300	COG2188	Transcriptional regulator
A4V04_RS09305	COG1473	amidohydrolase
A4V04_RS09310	COG2223	nitrite transmembrane transporter activity
A4V04_RS09315	COG3069	C4-dicarboxylate transmembrane transporter activity
A4V04_RS09340	COG3069	C4-dicarboxylate transmembrane transporter activity
A4V04_RS09345	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A4V04_RS09355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A4V04_RS09360	COG1309	transcriptional regulator
A4V04_RS09365	COG0793	Belongs to the peptidase S41A family
A4V04_RS09370	COG4942	peptidase
A4V04_RS09375	COG0588	phosphoglycerate mutase activity
A4V04_RS09415	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A4V04_RS09430	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A4V04_RS09440	COG3845	ABC transporter
A4V04_RS09445	COG4603	Belongs to the binding-protein-dependent transport system permease family
A4V04_RS09450	COG1079	Belongs to the binding-protein-dependent transport system permease family
A4V04_RS09465	COG0573	inorganic phosphate transmembrane transporter activity
A4V04_RS09475	COG1733	regulation of RNA biosynthetic process
A4V04_RS09480	COG2910	NAD(P)H-binding
A4V04_RS09485	COG2252	PERMEase
A4V04_RS09490	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A4V04_RS09495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A4V04_RS09505	COG1136	(ABC) transporter
A4V04_RS09510	COG0248	Ppx GppA phosphatase
A4V04_RS09520	COG0742	ribosomal rna small subunit methyltransferase
A4V04_RS09525	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A4V04_RS09535	COG1053	succinate dehydrogenase
A4V04_RS09545	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A4V04_RS09555	COG0277	FAD linked oxidase domain protein
A4V04_RS09560	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A4V04_RS09570	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4V04_RS09575	COG1757	Na H antiporter
A4V04_RS09580	COG4235	cytochrome complex assembly
A4V04_RS09580	COG3088	subunit of a heme lyase
A4V04_RS09585	COG1138	Cytochrome C-type biogenesis protein
A4V04_RS09595	COG0165	Argininosuccinate lyase
A4V04_RS09615	COG2249	NAD(P)H dehydrogenase (quinone) activity
A4V04_RS09625	COG1027	Aspartate ammonia-lyase
A4V04_RS09650	COG0583	DNA-binding transcription factor activity
A4V04_RS09655	COG1027	Aspartate ammonia-lyase
A4V04_RS09660	COG0583	DNA-binding transcription factor activity
A4V04_RS09690	COG0114	fumarate hydratase activity
A4V04_RS09695	COG1027	Aspartate ammonia-lyase
A4V04_RS09700	COG0697	spore germination
A4V04_RS09705	COG0583	DNA-binding transcription factor activity
A4V04_RS09710	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4V04_RS09720	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A4V04_RS09725	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A4V04_RS09730	COG0772	Belongs to the SEDS family
A4V04_RS09735	COG0768	penicillin binding
A4V04_RS09750	COG1077	Cell shape determining protein MreB Mrl
A4V04_RS09760	COG0154	amidase activity
A4V04_RS09780	COG0288	reversible hydration of carbon dioxide
A4V04_RS09800	COG3301	Polysulphide reductase, NrfD
A4V04_RS09805	COG0437	4 iron, 4 sulfur cluster binding
A4V04_RS09810	COG0484	heat shock protein binding
A4V04_RS09820	COG2414	aldehyde ferredoxin oxidoreductase
A4V04_RS09825	COG0437	4 iron, 4 sulfur cluster binding
A4V04_RS09830	COG0531	amino acid
A4V04_RS09840	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A4V04_RS09845	COG0708	Exodeoxyribonuclease III
A4V04_RS09850	COG1187	pseudouridine synthase activity
A4V04_RS09865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A4V04_RS09870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A4V04_RS09890	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A4V04_RS09895	COG0569	domain protein
A4V04_RS09900	COG2204	response regulator
A4V04_RS09905	COG5000	phosphorelay sensor kinase activity
A4V04_RS09920	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A4V04_RS09935	COG0551	DNA topoisomerase type I activity
A4V04_RS09935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A4V04_RS09945	COG1253	flavin adenine dinucleotide binding
A4V04_RS09970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A4V04_RS09975	COG4597	amino acid ABC transporter
A4V04_RS09980	COG0765	amino acid transport
A4V04_RS10000	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A4V04_RS10010	COG4178	(ABC) transporter
A4V04_RS10020	COG2801	Transposase and inactivated derivatives
A4V04_RS10025	COG2801	Transposase and inactivated derivatives
A4V04_RS10030	COG2801	Transposase and inactivated derivatives
A4V04_RS10040	COG3069	C4-dicarboxylate transmembrane transporter activity
A4V04_RS10045	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4V04_RS10050	COG0583	DNA-binding transcription factor activity
A4V04_RS10060	COG2195	Cleaves the N-terminal amino acid of tripeptides
A4V04_RS10065	COG3069	C4-dicarboxylate transmembrane transporter activity
A4V04_RS10070	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A4V04_RS10080	COG1053	succinate dehydrogenase
A4V04_RS10085	COG3976	FMN-binding domain protein
A4V04_RS10085	COG1053	succinate dehydrogenase
A4V04_RS10090	COG4191	Histidine kinase
A4V04_RS10095	COG4566	intracellular signal transduction
A4V04_RS10100	COG1301	dicarboxylic acid transport
A4V04_RS10115	COG3069	C4-dicarboxylate transmembrane transporter activity
A4V04_RS10120	COG0252	asparaginase activity
A4V04_RS10125	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A4V04_RS10140	COG1053	succinate dehydrogenase
A4V04_RS10160	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A4V04_RS10170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A4V04_RS10175	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A4V04_RS10180	COG0513	Belongs to the DEAD box helicase family
A4V04_RS10195	COG0012	GTP binding
A4V04_RS10205	COG0583	DNA-binding transcription factor activity
A4V04_RS10210	COG2954	triphosphatase activity
A4V04_RS10275	COG4566	intracellular signal transduction
A4V04_RS10295	COG1053	succinate dehydrogenase
A4V04_RS10295	COG3976	FMN-binding domain protein
A4V04_RS10295	COG0431	NADPH-dependent FMN reductase
A4V04_RS10300	COG1053	succinate dehydrogenase
A4V04_RS10300	COG3976	FMN-binding domain protein
A4V04_RS10305	COG4566	intracellular signal transduction
A4V04_RS10315	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A4V04_RS10325	COG2945	thiolester hydrolase activity
A4V04_RS10335	COG2921	Belongs to the UPF0250 family
A4V04_RS10340	COG0321	lipoyl(octanoyl) transferase activity
A4V04_RS10370	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
A4V04_RS10375	COG2823	Periplasmic or secreted lipoprotein
A4V04_RS10410	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A4V04_RS10415	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A4V04_RS10420	COG0594	ribonuclease P activity
A4V04_RS10425	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A4V04_RS10430	COG0706	membrane insertase activity
A4V04_RS10435	COG2814	Major facilitator Superfamily
A4V04_RS10440	COG2986	histidine ammonia-lyase
A4V04_RS10445	COG2986	histidine ammonia-lyase
A4V04_RS10455	COG1053	succinate dehydrogenase
A4V04_RS10460	COG1309	transcriptional regulator
A4V04_RS10470	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A4V04_RS10475	COG0445	tRNA wobble uridine modification
A4V04_RS10480	COG0357	Ribosomal RNA small subunit methyltransferase G
A4V04_RS10495	COG1053	succinate dehydrogenase
A4V04_RS10495	COG3976	FMN-binding domain protein
A4V04_RS10505	COG2986	histidine ammonia-lyase
A4V04_RS10525	COG3842	ATPase activity
A4V04_RS10535	COG1840	ABC-type Fe3 transport system, periplasmic component
A4V04_RS10550	COG1127	ABC transporter
A4V04_RS10555	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4V04_RS10560	COG1192	Involved in chromosome partitioning
A4V04_RS10565	COG1475	DNA binding
A4V04_RS10575	COG0356	it plays a direct role in the translocation of protons across the membrane
A4V04_RS10590	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A4V04_RS10600	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A4V04_RS10605	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A4V04_RS10610	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A4V04_RS10620	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A4V04_RS10625	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A4V04_RS10630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A4V04_RS10635	COG0826	peptidase U32
A4V04_RS10645	COG1280	lysine exporter protein (LysE YggA)
A4V04_RS10655	COG3069	C4-dicarboxylate transmembrane transporter activity
A4V04_RS10665	COG0583	DNA-binding transcription factor activity
A4V04_RS10675	COG2226	methyltransferase
A4V04_RS10690	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A4V04_RS10700	COG3976	FMN-binding domain protein
A4V04_RS10700	COG1053	succinate dehydrogenase
A4V04_RS10715	COG2188	Transcriptional regulator
A4V04_RS10720	COG2095	MarC family integral membrane protein
A4V04_RS10735	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
A4V04_RS10745	COG1053	succinate dehydrogenase
A4V04_RS10750	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A4V04_RS10755	COG0318	PFAM AMP-dependent synthetase and ligase
A4V04_RS10760	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A4V04_RS10770	COG0642	Histidine kinase
A4V04_RS10810	COG1294	oxidase, subunit
A4V04_RS10830	COG1053	succinate dehydrogenase
A4V04_RS10830	COG3976	FMN-binding domain protein
A4V04_RS10855	COG0583	DNA-binding transcription factor activity
A4V04_RS10865	COG2843	Capsule synthesis protein
A4V04_RS10890	COG3069	C4-dicarboxylate transmembrane transporter activity
A4V04_RS10895	COG2188	Transcriptional regulator
A4V04_RS10920	COG2304	oxidoreductase activity
A4V04_RS10925	COG0789	Transcriptional regulator
A4V04_RS10930	COG1222	aaa ATPase
A4V04_RS10935	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A4V04_RS10940	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
A4V04_RS10950	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
A4V04_RS10955	COG1140	nitrate reductase beta subunit
A4V04_RS10960	COG2181	nitrate reductase activity
A4V04_RS10965	COG0626	cystathionine gamma-synthase activity
A4V04_RS10970	COG0300	oxidoreductase activity
A4V04_RS10985	COG0018	arginyl-trna synthetase
A4V04_RS10990	COG1469	GTP cyclohydrolase I activity
A4V04_RS11025	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4V04_RS11035	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A4V04_RS11050	COG0081	regulation of translation
A4V04_RS11055	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A4V04_RS11060	COG0222	ribosome binding
A4V04_RS11065	COG0085	RNA polymerase activity
A4V04_RS11070	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A4V04_RS11075	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A4V04_RS11080	COG0049	tRNA binding
A4V04_RS11090	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A4V04_RS11095	COG0051	transcription antitermination factor activity, RNA binding
A4V04_RS11115	COG0697	spore germination
A4V04_RS11130	COG1053	succinate dehydrogenase
A4V04_RS11135	COG1477	protein flavinylation
A4V04_RS11140	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A4V04_RS11145	COG0088	Forms part of the polypeptide exit tunnel
A4V04_RS11150	COG0089	rRNA binding
A4V04_RS11155	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A4V04_RS11160	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A4V04_RS11165	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A4V04_RS11170	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A4V04_RS11175	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A4V04_RS11180	COG0255	Belongs to the universal ribosomal protein uL29 family
A4V04_RS11190	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A4V04_RS11195	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A4V04_RS11200	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A4V04_RS11205	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A4V04_RS11210	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A4V04_RS11215	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A4V04_RS11225	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A4V04_RS11230	COG1841	ribosomal large subunit assembly
A4V04_RS11235	COG0200	Binds to the 23S rRNA
A4V04_RS11240	COG0201	protein transport
A4V04_RS11245	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A4V04_RS11250	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A4V04_RS11260	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A4V04_RS11265	COG0202	RNA polymerase activity
A4V04_RS11270	COG0203	ribosomal protein L17
A4V04_RS11275	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A4V04_RS11290	COG0243	molybdopterin cofactor binding
A4V04_RS11325	COG0437	4 iron, 4 sulfur cluster binding
A4V04_RS11345	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
A4V04_RS11345	COG0493	'glutamate synthase
A4V04_RS11355	COG1053	succinate dehydrogenase
A4V04_RS11355	COG0431	NADPH-dependent FMN reductase
A4V04_RS11355	COG3976	FMN-binding domain protein
A4V04_RS11370	COG0456	acetyltransferase
A4V04_RS11375	COG4650	regulator
A4V04_RS11385	COG1690	Belongs to the RtcB family
A4V04_RS11395	COG0252	asparaginase activity
A4V04_RS11425	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A4V04_RS11460	COG1053	succinate dehydrogenase
A4V04_RS11465	COG1053	succinate dehydrogenase
A4V04_RS11470	COG1053	succinate dehydrogenase
A4V04_RS11475	COG1053	succinate dehydrogenase
A4V04_RS11475	COG3976	FMN-binding domain protein
A4V04_RS11485	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4V04_RS11490	COG1396	sequence-specific DNA binding
A4V04_RS11495	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
A4V04_RS11495	COG1017	nitric oxide dioxygenase activity
A4V04_RS11505	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A4V04_RS11520	COG0824	Thioesterase
A4V04_RS11525	COG0811	peptide transport
A4V04_RS11540	COG1511	domain protein
A4V04_RS11540	COG3264	Mechanosensitive ion channel
A4V04_RS11555	COG0442	prolyl-tRNA aminoacylation
A4V04_RS11560	COG0494	nUDIX hydrolase
A4V04_RS11565	COG0675	Transposase, IS605 OrfB family
A4V04_RS11575	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A4V04_RS11580	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A4V04_RS11585	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A4V04_RS11600	COG1301	dicarboxylic acid transport
A4V04_RS11605	COG1473	amidohydrolase
A4V04_RS11610	COG0142	geranyltranstransferase activity
A4V04_RS11645	COG2189	Belongs to the N(4) N(6)-methyltransferase family
A4V04_RS11725	COG0114	fumarate hydratase activity
A4V04_RS11735	COG0842	Transport permease protein
A4V04_RS11740	COG1131	(ABC) transporter
A4V04_RS11765	COG1129	ABC transporter
A4V04_RS11780	COG0811	peptide transport
A4V04_RS11785	COG0848	biopolymer transport protein
A4V04_RS11815	COG3069	C4-dicarboxylate transmembrane transporter activity
A4V04_RS11820	COG0165	Argininosuccinate lyase
A4V04_RS11830	COG1592	Rubrerythrin
A4V04_RS11845	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
A4V04_RS11850	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
A4V04_RS11855	COG0494	nUDIX hydrolase
A4V04_RS11865	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
A4V04_RS11870	COG0653	protein targeting
A4V04_RS11885	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A4V04_RS11890	COG0471	metal ion transport
A4V04_RS11895	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A4V04_RS11905	COG0849	cell division
A4V04_RS11910	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
A4V04_RS11915	COG1181	Belongs to the D-alanine--D-alanine ligase family
A4V04_RS11920	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A4V04_RS11925	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A4V04_RS11935	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A4V04_RS11940	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A4V04_RS11945	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A4V04_RS11950	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A4V04_RS11965	COG0275	rRNA processing
A4V04_RS11970	COG2001	Belongs to the MraZ family
A4V04_RS11985	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A4V04_RS11995	COG0733	neurotransmitter:sodium symporter activity
A4V04_RS12005	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A4V04_RS12010	COG0066	3-isopropylmalate dehydratase activity
A4V04_RS12020	COG0284	orotidine-5'-phosphate decarboxylase activity
A4V04_RS12035	COG3069	C4-dicarboxylate transmembrane transporter activity
A4V04_RS12050	COG0243	molybdopterin cofactor binding
A4V04_RS12050	COG3383	formate dehydrogenase (NAD+) activity
A4V04_RS12055	COG0437	4 iron, 4 sulfur cluster binding
A4V04_RS12080	COG0310	cobalt ion transport
A4V04_RS12090	COG1122	ATPase activity
A4V04_RS12095	COG3976	FMN-binding domain protein
A4V04_RS12095	COG1053	succinate dehydrogenase
A4V04_RS12105	COG3069	C4-dicarboxylate transmembrane transporter activity
A4V04_RS12115	COG0459	protein refolding
A4V04_RS12120	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A4V04_RS12130	COG4575	ribosome binding
A4V04_RS12160	COG1253	flavin adenine dinucleotide binding
A4V04_RS12170	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A4V04_RS12180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A4V04_RS12185	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A4V04_RS12190	COG0307	riboflavin synthase, alpha
A4V04_RS12195	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4V04_RS12195	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A4V04_RS12200	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A4V04_RS12205	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A4V04_RS12220	COG0739	heme binding
A4V04_RS12230	COG1490	D-aminoacyl-tRNA deacylase activity
A4V04_RS12240	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A4V04_RS12245	COG0318	PFAM AMP-dependent synthetase and ligase
A4V04_RS12255	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A4V04_RS12260	COG0700	Nucleoside recognition
A4V04_RS12265	COG3366	ferrous iron transmembrane transporter activity
A4V04_RS12285	COG1335	isochorismatase
A4V04_RS12290	COG2070	2-Nitropropane dioxygenase
A4V04_RS12305	COG0482	sulfurtransferase activity
A4V04_RS12310	COG0861	Integral membrane protein TerC family
A4V04_RS12315	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A4V04_RS12320	COG0045	succinate-CoA ligase (ADP-forming) activity
A4V04_RS12325	COG2137	regulation of response to DNA damage stimulus
A4V04_RS12330	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A4V04_RS12390	COG1053	succinate dehydrogenase
A4V04_RS12425	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A4V04_RS12430	COG2011	ABC-type metal ion transport system permease component
A4V04_RS12440	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A4V04_RS12445	COG1968	undecaprenyl-diphosphatase activity
A4V04_RS12455	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A4V04_RS12455	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A4V04_RS12460	COG0488	(ABC) transporter
A4V04_RS12475	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4V04_RS12480	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A4V04_RS12490	COG0140	phosphoribosyl-ATP diphosphatase activity
A4V04_RS12495	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A4V04_RS12500	COG0107	imidazoleglycerol-phosphate synthase activity
A4V04_RS12510	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A4V04_RS12515	COG0131	Imidazoleglycerol-phosphate dehydratase
A4V04_RS12520	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A4V04_RS12525	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A4V04_RS12530	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A4V04_RS12535	COG2194	sulfuric ester hydrolase activity
A4V04_RS12540	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
A4V04_RS12545	COG1215	transferase activity, transferring glycosyl groups
A4V04_RS12550	COG1215	transferase activity, transferring glycosyl groups
A4V04_RS12610	COG2853	Lipoprotein
A4V04_RS12615	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A4V04_RS12620	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A4V04_RS12625	COG1127	ABC transporter
A4V04_RS12635	COG1053	succinate dehydrogenase
A4V04_RS12650	COG0069	glutamate synthase activity
A4V04_RS12650	COG0067	glutamate synthase
A4V04_RS12650	COG0070	glutamate synthase
A4V04_RS12670	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A4V04_RS12680	COG0232	Belongs to the dGTPase family. Type 2 subfamily
A4V04_RS12685	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A4V04_RS12690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A4V04_RS12715	COG1053	succinate dehydrogenase
A4V04_RS12765	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
A4V04_RS12775	COG0789	Transcriptional regulator
A4V04_RS12775	COG4978	Transcriptional regulator
A4V04_RS12815	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A4V04_RS12820	COG1120	ATPase activity
A4V04_RS12825	COG2226	methyltransferase
A4V04_RS12830	COG0864	Transcriptional regulator
A4V04_RS12860	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A4V04_RS12895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A4V04_RS12900	COG1674	ftsk spoiiie
A4V04_RS12915	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A4V04_RS12935	COG1053	succinate dehydrogenase
A4V04_RS12945	COG2770	Histidine kinase
A4V04_RS12945	COG2205	protein histidine kinase activity
A4V04_RS12950	COG1053	succinate dehydrogenase
A4V04_RS12950	COG3976	FMN-binding domain protein
A4V04_RS12955	COG1053	succinate dehydrogenase
A4V04_RS12970	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A4V04_RS12980	COG4149	molybdate abc transporter
A4V04_RS12990	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A4V04_RS12995	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A4V04_RS13000	COG1074	ATP-dependent DNA helicase activity
A4V04_RS13030	COG0632	four-way junction helicase activity
A4V04_RS13040	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A4V04_RS13055	COG3023	N-Acetylmuramoyl-L-alanine amidase
A4V04_RS13080	COG1982	Orn Lys Arg decarboxylase major
A4V04_RS13085	COG0531	amino acid
A4V04_RS13100	COG0556	nucleotide-excision repair
A4V04_RS13105	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A4V04_RS13110	COG1959	2 iron, 2 sulfur cluster binding
A4V04_RS13115	COG1104	cysteine desulfurase activity
A4V04_RS13125	COG0316	Belongs to the HesB IscA family