locus-tag class description BADSM9389_RS00005 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) BADSM9389_RS00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) BADSM9389_RS00015 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BADSM9389_RS00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BADSM9389_RS00025 ENOG4105VP5 Bacterial protein of unknown function (DUF937) BADSM9389_RS00030 ENOG410667J hydrolase BADSM9389_RS00035 ENOG4105EMF GntR family transcriptional regulator BADSM9389_RS00040 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 BADSM9389_RS00045 ENOG4108RTU Aldolase BADSM9389_RS00050 ENOG4105CXK mandelate racemase muconate lactonizing BADSM9389_RS00055 ENOG4105DJB Major Facilitator Superfamily BADSM9389_RS00065 ENOG4105D99 atp gtp-binding protein BADSM9389_RS00070 ENOG4105R2A (LipO)protein BADSM9389_RS00075 ENOG4108ZNX Heat shock protein BADSM9389_RS00090 ENOG4105FDP GntR family transcriptional regulator BADSM9389_RS00095 ENOG4105CI1 PTS System BADSM9389_RS00100 ENOG4105F8D glycoside hydrolase family 4 BADSM9389_RS00115 ENOG4105W8I Transcriptional regulator BADSM9389_RS00120 ENOG4106PMH Extracellular solute-binding protein family 3 BADSM9389_RS00125 ENOG4105E5Q amino acid AbC transporter BADSM9389_RS00130 ENOG4105CDA abc transporter atp-binding protein BADSM9389_RS00135 ENOG4105E5M Multidrug resistance protein D BADSM9389_RS00155 ENOG4108ZG0 Ompa motb domain protein BADSM9389_RS00160 ENOG4107QY8 reductase BADSM9389_RS00170 ENOG4108R3E Dna-3-methyladenine glycosylase i BADSM9389_RS00175 ENOG4105EAX Putative lipase BADSM9389_RS00180 ENOG4105FCD Major Facilitator BADSM9389_RS00190 ENOG4105DIJ Phosphoethanolamine transferase BADSM9389_RS00200 ENOG4105DEF Extracellular solute-binding protein, family 5 BADSM9389_RS00205 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BADSM9389_RS00210 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BADSM9389_RS00215 ENOG4105C3U ABC transporter BADSM9389_RS00220 ENOG4108JQ7 (ABC) transporter BADSM9389_RS00235 ENOG4105UTS cellulose synthase operon protein YhjQ BADSM9389_RS00240 ENOG4107QZ7 Cellulose synthase catalytic subunit BADSM9389_RS00245 ENOG4107EEX Cellulose synthase regulator protein BADSM9389_RS00250 ENOG4105EJG cellulose synthase BADSM9389_RS00260 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) BADSM9389_RS00265 ENOG4105WDY DNA (cytosine-5-)-methyltransferase BADSM9389_RS00270 ENOG4105BZU Histidine kinase BADSM9389_RS00275 ENOG4105CK2 sodium dicarboxylate symporter BADSM9389_RS00280 ENOG4105CS0 peptidase BADSM9389_RS00285 ENOG4107SS6 2-dehydro-3-deoxygluconokinase BADSM9389_RS00290 ENOG4105CMB EAL domain-containing protein BADSM9389_RS00295 ENOG41066T0 asmA family BADSM9389_RS00300 ENOG4105CSH Transporter BADSM9389_RS00305 ENOG4107H3J ribonuclease BADSM9389_RS00310 ENOG4105CBN LysR family transcriptional regulator BADSM9389_RS00315 ENOG4105CHR reductase BADSM9389_RS00320 ENOG4105VMI -acetyltransferase BADSM9389_RS00335 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BADSM9389_RS00345 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) BADSM9389_RS00350 ENOG4105VCP PTS System BADSM9389_RS00355 ENOG4105CK1 PTS System BADSM9389_RS00360 ENOG4105VZJ PTS System BADSM9389_RS00365 ENOG4105ETE Transcriptional regulator (LacI family BADSM9389_RS00375 ENOG4105DC8 reductase BADSM9389_RS00380 ENOG4105D6S protein involved in catabolism of external DNA BADSM9389_RS00385 ENOG4105DGW oligopeptidase A BADSM9389_RS00400 ENOG4108V6B universal stress protein B BADSM9389_RS00405 ENOG4105CJ3 phosphate transporter BADSM9389_RS00410 ENOG4105CBX hi0933 family BADSM9389_RS00415 ENOG4105E8G Major facilitator Superfamily BADSM9389_RS00425 ENOG4105DSF transport protein BADSM9389_RS00430 ENOG4105F9N Major Facilitator Superfamily BADSM9389_RS00435 ENOG4108W1V Lipoprotein BADSM9389_RS00440 ENOG4105EX9 Membrane BADSM9389_RS00445 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) BADSM9389_RS00450 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BADSM9389_RS00460 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BADSM9389_RS00470 ENOG4107FS9 Membrane BADSM9389_RS00480 ENOG4105MG3 Membrane BADSM9389_RS00485 ENOG4106H78 methyltransferase BADSM9389_RS00490 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) BADSM9389_RS00495 ENOG4105CAK Cell division ATP-binding protein ftsE BADSM9389_RS00500 ENOG4105CRP Part of the ABC transporter FtsEX involved in BADSM9389_RS00505 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BADSM9389_RS00510 ENOG4105CP9 extracellular ligand-binding receptor BADSM9389_RS00515 ENOG4105U59 -acetyltransferase BADSM9389_RS00520 ENOG4105CP9 extracellular ligand-binding receptor BADSM9389_RS00525 ENOG4105C32 Amino acid ABC transporter (Permease) BADSM9389_RS00530 ENOG4105CF8 branched-chain amino acid ABC transporter, permease BADSM9389_RS00535 ENOG4105C0Z ABC transporter BADSM9389_RS00540 ENOG4108IV0 ABC, transporter BADSM9389_RS00545 ENOG4105BZ7 extracellular solute-binding protein family 1 BADSM9389_RS00550 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component BADSM9389_RS00560 ENOG4108IJ9 (ABC) transporter BADSM9389_RS00565 ENOG4107T6V glycerophosphoryl diester phosphodiesterase BADSM9389_RS00570 ENOG4105WC8 Conserved Protein BADSM9389_RS00575 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BADSM9389_RS00580 ENOG4105WCN acetyltransferase BADSM9389_RS00585 ENOG4105D9R oxidoreductase BADSM9389_RS00590 ENOG4105C2I pirin domain protein BADSM9389_RS00595 ENOG4105DIQ Transcriptional regulator BADSM9389_RS00600 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family BADSM9389_RS00605 ENOG4105C6Z Gluconate BADSM9389_RS00610 ENOG4105CMG Carbohydrate kinase BADSM9389_RS00615 ENOG4105C93 Xylose Isomerase BADSM9389_RS00620 ENOG4105DFW ABC transporter BADSM9389_RS00630 ENOG4108HWW ABC transporter BADSM9389_RS00635 ENOG4105T16 Transcriptional regulator (AraC family) BADSM9389_RS00640 ENOG4108UR8 BAX protein BADSM9389_RS00645 ENOG4107T9C Alpha amylase catalytic region BADSM9389_RS00650 ENOG4105JKW Valine--pyruvate aminotransferase BADSM9389_RS00660 ENOG4105C8H hydrogenase maturation protein Hypf BADSM9389_RS00665 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BADSM9389_RS00670 ENOG4108RC0 Electron transport protein BADSM9389_RS00675 ENOG4108MG9 hydrogenase 3 maturation protease BADSM9389_RS00680 ENOG4105I6X formate hydrogenlyase maturation BADSM9389_RS00685 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit BADSM9389_RS00690 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit BADSM9389_RS00695 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BADSM9389_RS00700 ENOG4107TDF Formate hydrogenlyase subunit 4 BADSM9389_RS00705 ENOG4107R30 NADH dehydrogenase BADSM9389_RS00710 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) BADSM9389_RS00715 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA BADSM9389_RS00720 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) BADSM9389_RS00725 ENOG4107RSS Hydrogenase accessory protein HypB BADSM9389_RS00730 ENOG41083WG hydrogenase assembly chaperone BADSM9389_RS00735 ENOG4105CQS hydrogenase expression formation protein HypD BADSM9389_RS00740 ENOG4105C45 hydrogenase expression formation protein (HypE) BADSM9389_RS00750 ENOG4105N1F Hnh endonuclease BADSM9389_RS00755 ENOG4105ESV Glycosyl transferase, family 4 BADSM9389_RS00760 ENOG4105DAY polysaccharide export protein BADSM9389_RS00765 ENOG4105KJF protein tyrosine phosphatase BADSM9389_RS00770 ENOG4105D75 Capsular exopolysaccharide family BADSM9389_RS00800 ENOG4108MRJ BADSM9389_RS00805 ENOG4105ESV Glycosyl transferase, family 4 BADSM9389_RS00810 ENOG4105DAY polysaccharide export protein BADSM9389_RS00815 ENOG4105KJF protein tyrosine phosphatase BADSM9389_RS00820 ENOG4105D75 Capsular exopolysaccharide family BADSM9389_RS00840 ENOG4105E3R (LipO)protein BADSM9389_RS00845 ENOG4105C8Q Methyl-accepting chemotaxis BADSM9389_RS00855 ENOG4108TC1 Transcriptional regulator BADSM9389_RS00870 ENOG4105CT4 transporter BADSM9389_RS00880 ENOG4105EFX secretion protein, HlyD family BADSM9389_RS00885 ENOG4105KK7 inner membrane protein YiaW BADSM9389_RS00890 ENOG4108PNB DNA-binding transcriptional regulator BADSM9389_RS00895 ENOG4105UYK outer membrane protein a BADSM9389_RS00900 ENOG41066F8 ROK family BADSM9389_RS00905 ENOG4105C26 Dehydrogenase BADSM9389_RS00910 ENOG4105EM7 Selenocysteine-specific translation elongation factor BADSM9389_RS00920 ENOG4108U78 Glutathione S-transferase BADSM9389_RS00925 ENOG4105CTS PTS system mannitol-specific BADSM9389_RS00935 ENOG4105E61 Mannitol repressor protein BADSM9389_RS00940 ENOG4108YYI Protein of unknown function (DUF2810) BADSM9389_RS00950 ENOG41084S7 Plasmid maintenance system antidote protein BADSM9389_RS00955 ENOG4105C5I Dehydrogenase BADSM9389_RS00965 ENOG4105D7K pfkb domain protein BADSM9389_RS00975 ENOG4108M60 Transcriptional regulator BADSM9389_RS00980 ENOG4105D3W isochorismatase BADSM9389_RS00995 ENOG4105MEV Acyl-transferase BADSM9389_RS01005 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit BADSM9389_RS01010 ENOG4105C38 Glycyl-tRNA synthetase beta subunit BADSM9389_RS01015 ENOG4108RW8 Universal stress protein F BADSM9389_RS01020 ENOG4105MVF Transcriptional regulator BADSM9389_RS01025 ENOG4105D2S major facilitator superfamily BADSM9389_RS01030 ENOG4106JH6 (LipO)protein BADSM9389_RS01040 ENOG4108RPX mosc domain containing protein BADSM9389_RS01045 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BADSM9389_RS01055 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) BADSM9389_RS01060 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) BADSM9389_RS01065 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) BADSM9389_RS01070 ENOG4105DET Rhamnulokinase BADSM9389_RS01085 ENOG4105D4B ABC, transporter BADSM9389_RS01090 ENOG4105C2J ABC transporter BADSM9389_RS01095 ENOG4105CNN ABC, transporter BADSM9389_RS01100 ENOG4105CNN ABC, transporter BADSM9389_RS01105 ENOG4105C0A alcohol dehydrogenase BADSM9389_RS01110 ENOG4105M10 Involved in the anomeric conversion of L-rhamnose (By similarity) BADSM9389_RS01125 ENOG4105CS6 Rhs element vgr protein BADSM9389_RS01140 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia BADSM9389_RS01150 ENOG4105D2N Aldolase BADSM9389_RS01165 ENOG4105CTQ phosphohexokinase BADSM9389_RS01170 ENOG4108UW5 maltose o-acetyltransferase BADSM9389_RS01175 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) BADSM9389_RS01190 ENOG41064BA PTS system, fructose-specific, IIA component BADSM9389_RS01195 ENOG4105DM4 PTS System BADSM9389_RS01200 ENOG4105CN9 Peptidase m42 family protein BADSM9389_RS01205 ENOG4106C3V frv operon regulatory protein BADSM9389_RS01220 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BADSM9389_RS01225 ENOG4108MG3 formate dehydrogenase BADSM9389_RS01230 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) BADSM9389_RS01255 ENOG41068KX affects formate dehydrogenase-N BADSM9389_RS01260 ENOG4105SUV lipoprotein YgdR BADSM9389_RS01310 ENOG4105CJQ hydrolase, family 31 BADSM9389_RS01315 ENOG41076UM multiple antibiotic resistance (MarC)-related protein BADSM9389_RS01320 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BADSM9389_RS01325 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) BADSM9389_RS01330 ENOG4108IUM Glycogen debranching enzyme BADSM9389_RS01340 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) BADSM9389_RS01345 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) BADSM9389_RS01350 ENOG4105E98 transcriptional regulator DeoR family BADSM9389_RS01360 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) BADSM9389_RS01365 ENOG4105C6V Glycerol-3-phosphate dehydrogenase BADSM9389_RS01370 ENOG41061ZR Transcriptional regulator BADSM9389_RS01375 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) BADSM9389_RS01380 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) BADSM9389_RS01385 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) BADSM9389_RS01390 ENOG4105MJ2 Competence protein BADSM9389_RS01405 ENOG4105CE1 Ferrous iron transport protein b BADSM9389_RS01410 ENOG4105XFK Ferrous iron transport protein A BADSM9389_RS01415 ENOG4105BZM domain protein BADSM9389_RS01420 ENOG4108RRZ Transcription elongation factor GreB BADSM9389_RS01430 ENOG4105E0F Histidine kinase BADSM9389_RS01455 ENOG4105CS6 Rhs element vgr protein BADSM9389_RS01460 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase BADSM9389_RS01470 ENOG4105VEJ Heat shock protein BADSM9389_RS01475 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 BADSM9389_RS01480 ENOG4105DQY intracellular growth attenuator BADSM9389_RS01485 ENOG4107RK2 ADP-ribose diphosphatase NudE BADSM9389_RS01490 ENOG4108JQC penicillin-binding protein 1A BADSM9389_RS01495 ENOG4108U1Q Pilus assembly protein BADSM9389_RS01515 ENOG4105E4G Type IV pilus BADSM9389_RS01520 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BADSM9389_RS01530 ENOG4105EGB membrane protein DamX BADSM9389_RS01535 ENOG4105DFE Dna adenine methylase BADSM9389_RS01540 ENOG4105DJV ribulose-phosphate 3-epimerase BADSM9389_RS01550 ENOG4105C31 Tryptophanyl-tRNA synthetase BADSM9389_RS01555 ENOG4108M21 BADSM9389_RS01560 ENOG4105RMW regulation of transcription, DNA-dependent BADSM9389_RS01565 ENOG4108626 Racemase BADSM9389_RS01570 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) BADSM9389_RS01575 ENOG41080QX K07048 phosphotriesterase-related protein BADSM9389_RS01580 ENOG4105MUZ Protein of unknown function DUF2620 BADSM9389_RS01585 ENOG4106M0N transport system permease protein BADSM9389_RS01590 ENOG4106PKC pyridoxal phosphate binding BADSM9389_RS01595 ENOG4105VYH BADSM9389_RS01605 ENOG4107V9H nitrite transporter BADSM9389_RS01610 ENOG4105WZK nitrite reductase NADPH small subunit BADSM9389_RS01615 ENOG4107QZF nitrite reductase NADPH large subunit BADSM9389_RS01620 ENOG4105DZC cytosine deaminase BADSM9389_RS01625 ENOG4106DTQ Protein TsgA homolog BADSM9389_RS01630 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BADSM9389_RS01635 ENOG4105MZU cell filamentation protein BADSM9389_RS01645 ENOG4105C8Y Acetylornithine aminotransferase BADSM9389_RS01650 ENOG410613R integral membrane protein, YccS YhfK family BADSM9389_RS01655 ENOG4107RYR Transcriptional regulator, Crp Fnr family BADSM9389_RS01660 ENOG4108UKZ OsmC family BADSM9389_RS01665 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) BADSM9389_RS01670 ENOG4105YP7 UPF0270 protein BADSM9389_RS01675 ENOG4105DNZ Alpha Beta Hydrolase BADSM9389_RS01685 ENOG4105C5H ABC transporter BADSM9389_RS01690 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein BADSM9389_RS01695 ENOG4105CKD glutathione-regulated potassium-efflux system protein BADSM9389_RS01700 ENOG4105VKU nucleicacid-binding protein BADSM9389_RS01705 ENOG4108YZY peptidylprolyl cis-trans isomerase BADSM9389_RS01715 ENOG4108V1T peptidylprolyl cis-trans isomerase BADSM9389_RS01720 ENOG4105WWK YheO domain protein BADSM9389_RS01730 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) BADSM9389_RS01745 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) BADSM9389_RS01750 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) BADSM9389_RS01755 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BADSM9389_RS01760 ENOG4105W53 bacterioferritin-associated ferredoxin BADSM9389_RS01765 ENOG4108UQY Iron-storage protein BADSM9389_RS01780 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) BADSM9389_RS01785 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) BADSM9389_RS01790 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) BADSM9389_RS01800 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) BADSM9389_RS01805 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) BADSM9389_RS01815 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) BADSM9389_RS01820 ENOG41083MP 50s ribosomal protein l29 BADSM9389_RS01830 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) BADSM9389_RS01835 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) BADSM9389_RS01840 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits BADSM9389_RS01845 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) BADSM9389_RS01850 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) BADSM9389_RS01855 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) BADSM9389_RS01860 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) BADSM9389_RS01865 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) BADSM9389_RS01870 ENOG4105VPB 50S ribosomal protein L30 BADSM9389_RS01875 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) BADSM9389_RS01880 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) BADSM9389_RS01885 ENOG41067V7 50S ribosomal protein L36 BADSM9389_RS01895 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) BADSM9389_RS01900 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) BADSM9389_RS01905 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BADSM9389_RS01910 ENOG4108ZT0 50S ribosomal protein l17 BADSM9389_RS01915 ENOG4105W1Y Transcriptional regulator BADSM9389_RS01920 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system BADSM9389_RS01925 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) BADSM9389_RS01930 ENOG4105C1A potassium transporter peripheral membrane BADSM9389_RS01935 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B BADSM9389_RS01950 ENOG4105C79 DNA protecting protein DprA BADSM9389_RS01960 ENOG4108WI1 Dna topoisomerase BADSM9389_RS01965 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BADSM9389_RS01975 ENOG4105SG3 Protein of unknown function (DUF1488) BADSM9389_RS01980 ENOG4108Z0R Transferase BADSM9389_RS02020 ENOG4105CDA abc transporter atp-binding protein BADSM9389_RS02025 ENOG4105DRP amino acid AbC transporter BADSM9389_RS02030 ENOG4105EZ7 amino acid ABC transporter BADSM9389_RS02040 ENOG4105XCM membrane LIPOPROTEIN BADSM9389_RS02045 ENOG4105V2F Uncharacterized protein yoac BADSM9389_RS02090 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BADSM9389_RS02105 ENOG4108IA2 Sodium pantothenate symporter BADSM9389_RS02110 ENOG4105RG0 Membrane BADSM9389_RS02115 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase BADSM9389_RS02120 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein BADSM9389_RS02125 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) BADSM9389_RS02130 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) BADSM9389_RS02140 ENOG41062P1 Diguanylate cyclase phosphodiesterase BADSM9389_RS02150 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) BADSM9389_RS02155 ENOG4105VQ7 Rod shape-determining protein MreD BADSM9389_RS02160 ENOG4108Z03 MAF-like protein BADSM9389_RS02165 ENOG4105C03 ribonuclease BADSM9389_RS02170 ENOG4105QD6 exported protein BADSM9389_RS02175 ENOG4105D1U peptidase U62 modulator of DNA gyrase BADSM9389_RS02180 ENOG4105CR8 Transcriptional regulator BADSM9389_RS02185 ENOG4105ZQC membrane protein AaeX BADSM9389_RS02190 ENOG4105Y49 secretion protein, HlyD family BADSM9389_RS02195 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) BADSM9389_RS02200 ENOG4105C26 Dehydrogenase BADSM9389_RS02205 ENOG4105UNR (Barnase) inhibitor BADSM9389_RS02210 ENOG4105RID UPF0379 protein yhcN BADSM9389_RS02215 ENOG4105RID UPF0379 protein yhcN BADSM9389_RS02220 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) BADSM9389_RS02230 ENOG4105C0H protease BADSM9389_RS02235 ENOG4105C0H protease BADSM9389_RS02240 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III BADSM9389_RS02245 ENOG4105D6Z AFG1 family ATPase BADSM9389_RS02250 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) BADSM9389_RS02260 ENOG4107MKT Stringent starvation protein a BADSM9389_RS02265 ENOG4105KB2 stringent starvation protein b BADSM9389_RS02270 ENOG4108QBF Transcriptional regulator BADSM9389_RS02275 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BADSM9389_RS02280 ENOG4105JHE Major Facilitator Superfamily BADSM9389_RS02285 ENOG4105BZ8 glutamate synthase BADSM9389_RS02290 ENOG4105CBC glutamate synthase BADSM9389_RS02295 ENOG4105N5T Radical SAM Protein BADSM9389_RS02300 ENOG4105BZU Histidine kinase BADSM9389_RS02305 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain BADSM9389_RS02310 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase BADSM9389_RS02315 ENOG41080Z8 PHOSPHOCARRIER protein BADSM9389_RS02325 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN BADSM9389_RS02330 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA BADSM9389_RS02335 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BADSM9389_RS02340 ENOG4108IUZ ABC transporter BADSM9389_RS02345 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA BADSM9389_RS02350 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) BADSM9389_RS02360 ENOG4105C2X Arabinose 5-phosphate isomerase BADSM9389_RS02365 ENOG4105FEU K -dependent Na -Ca exchanger BADSM9389_RS02370 ENOG4105DHJ ABC, transporter BADSM9389_RS02375 ENOG4105CY3 ABC transporter, permease BADSM9389_RS02380 ENOG4107PE3 Mammalian cell entry related domain protein BADSM9389_RS02385 ENOG4105E3I toluene tolerance BADSM9389_RS02390 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane BADSM9389_RS02395 ENOG4105VFK BolA family BADSM9389_RS02400 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) BADSM9389_RS02405 ENOG4105HVQ Regulatory factor of maltose metabolism BADSM9389_RS02410 ENOG4105EAH synthase BADSM9389_RS02415 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) BADSM9389_RS02420 ENOG4105K46 50S ribosomal protein l27 BADSM9389_RS02425 ENOG4105QYV Membrane BADSM9389_RS02430 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control BADSM9389_RS02445 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase BADSM9389_RS02450 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) BADSM9389_RS02455 ENOG4105HBR Rna-binding protein BADSM9389_RS02465 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) BADSM9389_RS02470 ENOG4105EEI dihydropteroate synthase BADSM9389_RS02475 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) BADSM9389_RS02480 ENOG4105NTZ Preprotein translocase subunit SecG BADSM9389_RS02495 ENOG4105K7D Required for maturation of 30S ribosomal subunits (By similarity) BADSM9389_RS02500 ENOG4105CHV Transcription elongation factor NusA BADSM9389_RS02505 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) BADSM9389_RS02515 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) BADSM9389_RS02520 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) BADSM9389_RS02540 ENOG4105C1J atp-dependent rna helicase BADSM9389_RS02545 ENOG4105CIC tryptophan-specific transport protein BADSM9389_RS02550 ENOG4105DEN Luciferase family BADSM9389_RS02570 ENOG4108YYD acetyltransferase BADSM9389_RS02580 ENOG4108ZPB UPF0306 protein BADSM9389_RS02585 ENOG4105K4T epimerase BADSM9389_RS02590 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) BADSM9389_RS02595 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase BADSM9389_RS02600 ENOG4105CG3 alpha amylase, catalytic region BADSM9389_RS02605 ENOG4105C5Y PTS System BADSM9389_RS02610 ENOG4105D4X repressor BADSM9389_RS02620 ENOG4105E2D ec 3.2.1.52 BADSM9389_RS02625 ENOG4105KME endoribonuclease L-psp BADSM9389_RS02630 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) BADSM9389_RS02635 ENOG4105CXT aspartate transcarbamylase BADSM9389_RS02640 ENOG4105D5Q Arginine ornithine antiporter BADSM9389_RS02645 ENOG4105CXN decarboxylase BADSM9389_RS02655 ENOG4105XEP YhcH YjgK YiaL family protein BADSM9389_RS02665 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) BADSM9389_RS02670 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase BADSM9389_RS02675 ENOG4108MJ3 acetyltransferase BADSM9389_RS02680 ENOG4108M3P Membrane BADSM9389_RS02690 ENOG4105MYG DNA polymerase iii, chi subunit BADSM9389_RS02695 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BADSM9389_RS02700 ENOG4108M8S permease YjgP YjgQ family protein BADSM9389_RS02705 ENOG4108K5H permease YjgP YjgQ family protein BADSM9389_RS02710 ENOG4105D7A ATP-binding protein BADSM9389_RS02720 ENOG4108VKG metal-dependent hydrolase BADSM9389_RS02725 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) BADSM9389_RS02730 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BADSM9389_RS02740 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) BADSM9389_RS02745 ENOG4105DKT Transcriptional regulator BADSM9389_RS02750 ENOG4105C2J ABC transporter BADSM9389_RS02755 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane BADSM9389_RS02760 ENOG4105F5R ABC transporter BADSM9389_RS02765 ENOG4105D4B ABC, transporter BADSM9389_RS02770 ENOG41061GT Aldolase BADSM9389_RS02775 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound BADSM9389_RS02780 ENOG4105C8Y Acetylornithine aminotransferase BADSM9389_RS02785 ENOG4108JQ7 (ABC) transporter BADSM9389_RS02790 ENOG4105C3U ABC transporter BADSM9389_RS02795 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BADSM9389_RS02800 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BADSM9389_RS02810 ENOG4105CSH Transporter BADSM9389_RS02815 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor BADSM9389_RS02820 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein BADSM9389_RS02825 ENOG4105DDV Transcriptional regulator (LacI family BADSM9389_RS02830 ENOG4105C5Y PTS System BADSM9389_RS02835 ENOG4105CS2 ec 3.2.1.21 BADSM9389_RS02845 ENOG4105RI1 glycoprotein receptor BADSM9389_RS02855 ENOG4107XM3 UPF0442 protein BADSM9389_RS02860 ENOG4105DWK Membrane BADSM9389_RS02865 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase BADSM9389_RS02880 ENOG4108N8T regulatoR BADSM9389_RS02885 ENOG4108UIN ybak prolyl-trna synthetase associated region BADSM9389_RS02890 ENOG4105CK1 PTS System BADSM9389_RS02895 ENOG4108819 ferric iron reductase BADSM9389_RS02900 ENOG4105BZU Histidine kinase BADSM9389_RS02905 ENOG4105YBH Protein of unknown function (DUF1435) BADSM9389_RS02930 ENOG4108WPU DNA polymerase III subunit psi BADSM9389_RS02935 ENOG4105KEG ribosomal-protein-alanine acetyltransferase BADSM9389_RS02940 ENOG4105PAD Hydrolase BADSM9389_RS02945 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) BADSM9389_RS02950 ENOG4105K3G Periplasmic Protein BADSM9389_RS02960 ENOG4108NRW Phospholipase, patatin family BADSM9389_RS02965 ENOG4105EYA deoxyribonuclease BADSM9389_RS02970 ENOG4105D9N nucleoside BADSM9389_RS02975 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) BADSM9389_RS02990 ENOG4105D3A purine nucleoside phosphorylase DeoD-type BADSM9389_RS02995 ENOG4105EUP HipA domain protein BADSM9389_RS03005 ENOG41062Z9 Membrane BADSM9389_RS03010 ENOG4105EAC phosphoserine phosphatase BADSM9389_RS03015 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) BADSM9389_RS03020 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase BADSM9389_RS03025 ENOG4105C5H ABC transporter BADSM9389_RS03030 ENOG4107SC1 transglycosylase BADSM9389_RS03035 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) BADSM9389_RS03040 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BADSM9389_RS03045 ENOG4105CVJ phosphoglycerate mutase BADSM9389_RS03050 ENOG4105UEI Transcriptional Regulator AraC Family BADSM9389_RS03055 ENOG4108RH0 Crea protein BADSM9389_RS03060 ENOG4105E3W Two component transcriptional regulator (Winged helix family BADSM9389_RS03065 ENOG4105EB3 Histidine kinase BADSM9389_RS03070 ENOG4105CT7 inner membrane cred family protein BADSM9389_RS03075 ENOG41065U4 response regulator BADSM9389_RS03085 ENOG4106FVC RNA methyltransferase BADSM9389_RS03095 ENOG4105CFH Aspartokinase BADSM9389_RS03100 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) BADSM9389_RS03105 ENOG4105D98 threonine synthase BADSM9389_RS03110 ENOG41062C6 Protein of unknown function (DUF2502) BADSM9389_RS03115 ENOG4105D1Q UPF0246 protein BADSM9389_RS03120 ENOG4105BZG amino acid carrier protein BADSM9389_RS03125 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BADSM9389_RS03130 ENOG4108RIR Molybdenum cofactor biosynthesis protein BADSM9389_RS03140 ENOG4106HK8 GPR1 FUN34 yaaH family protein BADSM9389_RS03150 ENOG4105CFG Acts as a chaperone (By similarity) BADSM9389_RS03155 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) BADSM9389_RS03160 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) BADSM9389_RS03165 ENOG41063Z6 transcriptional regulator, lysR family BADSM9389_RS03175 ENOG4105DTN riboflavin biosynthesis protein ribF BADSM9389_RS03180 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) BADSM9389_RS03185 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) BADSM9389_RS03190 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase BADSM9389_RS03195 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) BADSM9389_RS03200 ENOG4105CHR reductase BADSM9389_RS03205 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BADSM9389_RS03210 ENOG4105C01 Dihydroxy-acid dehydratase BADSM9389_RS03215 ENOG4105CSP Major Facilitator Superfamily BADSM9389_RS03220 ENOG4107QNK )-transporter BADSM9389_RS03225 ENOG4108RTU Aldolase BADSM9389_RS03230 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 BADSM9389_RS03240 ENOG4105DU0 nucleoside hydrolase BADSM9389_RS03245 ENOG4108Y83 glucose-6-phosphate isomerase BADSM9389_RS03255 ENOG4105F3R pts system mannose fructose sorbose family iid BADSM9389_RS03260 ENOG4105ETZ PTS System BADSM9389_RS03265 ENOG4105DAS pts system BADSM9389_RS03280 ENOG4107P2S Transcriptional regulator BADSM9389_RS03290 ENOG4105CT4 transporter BADSM9389_RS03295 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) BADSM9389_RS03310 ENOG4105CMD Transcriptional regulator, GntR family BADSM9389_RS03320 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain BADSM9389_RS03325 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain BADSM9389_RS03330 ENOG4105M5B (LipO)protein BADSM9389_RS03345 ENOG4105CCF Lysine exporter protein (Lyse ygga) BADSM9389_RS03350 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) BADSM9389_RS03355 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) BADSM9389_RS03360 ENOG4105NWN ApaG protein BADSM9389_RS03365 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) BADSM9389_RS03370 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) BADSM9389_RS03380 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) BADSM9389_RS03390 ENOG4105D3G Pseudouridine synthase BADSM9389_RS03395 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) BADSM9389_RS03400 ENOG4105CQ2 DNA polymerase BADSM9389_RS03415 ENOG4105GMB type VI secretion system effector, hcp1 family BADSM9389_RS03420 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase BADSM9389_RS03425 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) BADSM9389_RS03430 ENOG4105EF1 ribulokinase BADSM9389_RS03440 ENOG4108KF1 Membrane BADSM9389_RS03450 ENOG4106SMU thiamine transporter membrane protein BADSM9389_RS03470 ENOG4105S8Q sugar efflux transporter BADSM9389_RS03475 ENOG4105CSA Coproporphyrinogen iii oxidase BADSM9389_RS03480 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) BADSM9389_RS03485 ENOG4105VZ9 UPF0235 protein BADSM9389_RS03490 ENOG4108VIA integral membrane protein BADSM9389_RS03495 ENOG4105DFA alanine racemase domain protein BADSM9389_RS03500 ENOG4105CZX twitching motility protein BADSM9389_RS03515 ENOG4108UJU UPF0301 protein BADSM9389_RS03520 ENOG4105D7Z glutathione synthase BADSM9389_RS03525 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) BADSM9389_RS03530 ENOG4105RWS endonuclease I BADSM9389_RS03535 ENOG4105GPY SprT protein BADSM9389_RS03540 ENOG4107QNK )-transporter BADSM9389_RS03545 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BADSM9389_RS03555 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) BADSM9389_RS03560 ENOG4105CYW agmatinase BADSM9389_RS03565 ENOG4108K0D peptidase, M48 BADSM9389_RS03570 ENOG4105CV1 Transketolase (EC 2.2.1.1) BADSM9389_RS03575 ENOG4108NS2 receptor BADSM9389_RS03580 ENOG4105D05 Receptor BADSM9389_RS03585 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia BADSM9389_RS03590 ENOG4105CTS PTS system mannitol-specific BADSM9389_RS03595 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein BADSM9389_RS03600 ENOG4108Q8A Fructose-1,6-bisphosphatase BADSM9389_RS03605 ENOG4108R4K DNA-binding, transcriptional regulator BADSM9389_RS03610 ENOG4107Z1W Fructose transport system kinase BADSM9389_RS03615 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BADSM9389_RS03620 ENOG4105BZA Phosphoglycerate kinase BADSM9389_RS03625 ENOG4105D2N Aldolase BADSM9389_RS03630 ENOG410811B TRANSCRIPTIONal BADSM9389_RS03635 ENOG4105C7B Threonine dehydratase BADSM9389_RS03640 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) BADSM9389_RS03645 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BADSM9389_RS03650 ENOG4105C6N Formate acetyltransferase BADSM9389_RS03655 ENOG4105D64 Mechanosensitive ion channel BADSM9389_RS03660 ENOG4108ZUB Lysine exporter protein (Lyse ygga) BADSM9389_RS03665 ENOG4105MPN Membrane BADSM9389_RS03670 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) BADSM9389_RS03675 ENOG4105E66 phosphoriboisomerase A BADSM9389_RS03680 ENOG4108JQ1 Dehydrogenase BADSM9389_RS03685 ENOG4108R5S membrane BADSM9389_RS03690 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase BADSM9389_RS03700 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) BADSM9389_RS03705 ENOG4105E07 UPF0149 protein BADSM9389_RS03710 ENOG4107RAQ aminopeptidase BADSM9389_RS03715 ENOG4105D0A hydroxylase BADSM9389_RS03720 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family BADSM9389_RS03725 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) BADSM9389_RS03730 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) BADSM9389_RS03740 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BADSM9389_RS03750 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) BADSM9389_RS03755 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) BADSM9389_RS03760 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BADSM9389_RS03765 ENOG4105BZU Histidine kinase BADSM9389_RS03770 ENOG4105CS2 ec 3.2.1.21 BADSM9389_RS03775 ENOG4108Q3X Transcriptional regulator BADSM9389_RS03780 ENOG4108UT2 hemolysin iii BADSM9389_RS03795 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB BADSM9389_RS03800 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) BADSM9389_RS03805 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BADSM9389_RS03810 ENOG4105T95 Thiol disulfide interChange protein BADSM9389_RS03815 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) BADSM9389_RS03825 ENOG4105CRK lysyL-tRNA synthetase BADSM9389_RS03830 ENOG4108K5P (LipO)protein BADSM9389_RS03850 ENOG4105CGD Nad-dependent epimerase dehydratase BADSM9389_RS03855 ENOG4105EQ2 LysR family Transcriptional regulator BADSM9389_RS03860 ENOG4107SET aldo keto reductase BADSM9389_RS03890 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BADSM9389_RS03895 ENOG4105DEN Luciferase family BADSM9389_RS03910 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BADSM9389_RS03915 ENOG4105F27 Major Facilitator BADSM9389_RS03940 ENOG4105GR3 Histidine kinase BADSM9389_RS03950 ENOG4105CPC Aldo Keto reductase BADSM9389_RS03955 ENOG4105ENX hydrolase BADSM9389_RS03965 ENOG4108K2B transcriptional regulator BADSM9389_RS03970 ENOG4105F8D glycoside hydrolase family 4 BADSM9389_RS03975 ENOG4105CT4 transporter BADSM9389_RS03980 ENOG4105W3H MtN3 and saliva related transmembrane protein BADSM9389_RS03985 ENOG4106NDP Transcriptional regulator BADSM9389_RS03995 ENOG4108HKT sucrose-6-phosphate hydrolase BADSM9389_RS04005 ENOG4105D7K pfkb domain protein BADSM9389_RS04010 ENOG4105BZU Histidine kinase BADSM9389_RS04015 ENOG4105BZU Histidine kinase BADSM9389_RS04020 ENOG4105CK1 PTS System BADSM9389_RS04045 ENOG4108JJA ABC, transporter BADSM9389_RS04050 ENOG4105DFG type I secretion outer membrane protein BADSM9389_RS04065 ENOG4105BZU Histidine kinase BADSM9389_RS04085 ENOG4105BZU Histidine kinase BADSM9389_RS04090 ENOG4105BZU Histidine kinase BADSM9389_RS04095 ENOG4105C8Q Methyl-accepting chemotaxis BADSM9389_RS04100 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BADSM9389_RS04105 ENOG4105BZU Histidine kinase BADSM9389_RS04110 ENOG4105CBS Chea signal transduction histidine kinase BADSM9389_RS04135 ENOG410620I Diguanylate cyclase BADSM9389_RS04140 ENOG4105CHU acetyl-coa acetyltransferase BADSM9389_RS04145 ENOG4108QGT oligogalacturonate-specific porin BADSM9389_RS04150 ENOG4105CAZ oligogalacturonide lyase BADSM9389_RS04155 ENOG4105CHR reductase BADSM9389_RS04160 ENOG4105CAZ oligogalacturonide lyase BADSM9389_RS04175 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component BADSM9389_RS04180 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component BADSM9389_RS04195 ENOG4105F27 Major Facilitator BADSM9389_RS04200 ENOG4105RQF LysR family Transcriptional regulator BADSM9389_RS04210 ENOG4105DDV Transcriptional regulator (LacI family BADSM9389_RS04215 ENOG4105CK1 PTS System BADSM9389_RS04220 ENOG4105CS2 ec 3.2.1.21 BADSM9389_RS04225 ENOG4107YCY Transcriptional regulator BADSM9389_RS04255 ENOG41060NJ transcriptional regulator BADSM9389_RS04265 ENOG4105CEY Amp-dependent synthetase and ligase BADSM9389_RS04270 ENOG4107S74 Lysophospholipid transporter LplT BADSM9389_RS04275 ENOG4105CPC Aldo Keto reductase BADSM9389_RS04280 ENOG4105SUV lipoprotein YgdR BADSM9389_RS04285 ENOG4105EE5 Membrane protein terC BADSM9389_RS04295 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) BADSM9389_RS04300 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase BADSM9389_RS04305 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) BADSM9389_RS04310 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) BADSM9389_RS04315 ENOG4105IPU prepilin peptidase dependent protein A BADSM9389_RS04320 ENOG4105JCS prepilin peptidase dependent protein BADSM9389_RS04330 ENOG4105RVB Prepilin peptidase dependent protein c BADSM9389_RS04335 ENOG4105DSY exodeoxyribonuclease V, gamma BADSM9389_RS04340 ENOG4107QXK peptidase BADSM9389_RS04345 ENOG4107QKA exodeoxyribonuclease V beta BADSM9389_RS04350 ENOG4107QYX exodeoxyribonuclease v alpha BADSM9389_RS04355 ENOG4107QZM n-acetylglutamate synthase BADSM9389_RS04360 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BADSM9389_RS04380 ENOG4105CA3 membrane-bound lytic murein transglycosylase BADSM9389_RS04385 ENOG4105CUZ uba thif-type nad fad binding protein BADSM9389_RS04390 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) BADSM9389_RS04395 ENOG4105C9B Cysteine desulfurase BADSM9389_RS04400 ENOG4105M5B (LipO)protein BADSM9389_RS04405 ENOG4105ETT transcriptional Regulator, LysR family BADSM9389_RS04410 ENOG4105M08 Membrane BADSM9389_RS04415 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) BADSM9389_RS04420 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease BADSM9389_RS04425 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BADSM9389_RS04430 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) BADSM9389_RS04435 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) BADSM9389_RS04440 ENOG4105EJQ L-serine dehydratase BADSM9389_RS04445 ENOG4105C44 Serine transporter BADSM9389_RS04450 ENOG4105EWT decarboxylase family BADSM9389_RS04465 ENOG4105WP7 tRNA pseudouridine synthase C BADSM9389_RS04470 ENOG4105DR9 pseudouridine synthase BADSM9389_RS04475 ENOG4105QDK Flavodoxin BADSM9389_RS04480 ENOG4105DJB Major Facilitator Superfamily BADSM9389_RS04485 ENOG4105EQX glucarate dehydratase BADSM9389_RS04490 ENOG4105EQX glucarate dehydratase BADSM9389_RS04495 ENOG4105BZW Glycerate kinase BADSM9389_RS04500 ENOG4105BZU Histidine kinase BADSM9389_RS04505 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) BADSM9389_RS04510 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BADSM9389_RS04515 ENOG4108WC9 type VI secretion system effector, hcp1 family BADSM9389_RS04525 ENOG4105DXN mazG family BADSM9389_RS04530 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BADSM9389_RS04535 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) BADSM9389_RS04540 ENOG4105DQ4 alcohol dehydrogenase BADSM9389_RS04550 ENOG4108P2H Inner membrane protein YjiG BADSM9389_RS04555 ENOG41074DU domain protein BADSM9389_RS04560 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) BADSM9389_RS04565 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase BADSM9389_RS04570 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) BADSM9389_RS04580 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) BADSM9389_RS04585 ENOG4108MXK alkaline phosphatase isozyme conversion BADSM9389_RS04590 ENOG4105C11 sulfate adenylyltransferase), subunit 2 BADSM9389_RS04595 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) BADSM9389_RS04600 ENOG4107UCJ Catalyzes the synthesis of activated sulfate (By similarity) BADSM9389_RS04605 ENOG4105N0Z inner membrane protein ygbE BADSM9389_RS04610 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) BADSM9389_RS04640 ENOG4108K5P (LipO)protein BADSM9389_RS04645 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BADSM9389_RS04650 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) BADSM9389_RS04655 ENOG4105CVE Lytic murein transglycosylase BADSM9389_RS04660 ENOG4105C2X Arabinose 5-phosphate isomerase BADSM9389_RS04665 ENOG410804X Transcriptional regulator BADSM9389_RS04670 ENOG4105J92 DNA-binding transcriptional activator GutM BADSM9389_RS04675 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase BADSM9389_RS04680 ENOG4105VI0 Pts system, glucitol sorbitol-specific BADSM9389_RS04685 ENOG4105DZY Pts system, glucitol sorbitol-specific BADSM9389_RS04690 ENOG410787A Pts system, glucitol sorbitol-specific BADSM9389_RS04695 ENOG4105DIK (ABC) transporter BADSM9389_RS04700 ENOG4105CC5 ABC transporter BADSM9389_RS04705 ENOG4105DSE periplasmic solute binding protein BADSM9389_RS04710 ENOG4107TH8 cina domain protein BADSM9389_RS04715 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) BADSM9389_RS04720 ENOG4105Y3E Modulates RecA activity (By similarity) BADSM9389_RS04725 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) BADSM9389_RS04730 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) BADSM9389_RS04760 ENOG4107VXZ Hydrolase BADSM9389_RS04765 ENOG4105W39 Membrane BADSM9389_RS04775 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) BADSM9389_RS04780 ENOG4105C0R drug resistance transporter emrb qaca subfamily BADSM9389_RS04785 ENOG4105CW7 secretion protein, HlyD family BADSM9389_RS04790 ENOG4105NTK Transcriptional repressor Mpra BADSM9389_RS04795 ENOG4105ZED uncharacterized protein ygaH BADSM9389_RS04800 ENOG4108UMN azlc family BADSM9389_RS04805 ENOG4105EQ0 Major Facilitator superfamily BADSM9389_RS04810 ENOG4105GIJ Glycine betaine BADSM9389_RS04815 ENOG4108HQS Glycine betaine BADSM9389_RS04820 ENOG4108IJ7 Glycine betaine BADSM9389_RS04825 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BADSM9389_RS04830 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BADSM9389_RS04835 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) BADSM9389_RS04840 ENOG4105WAZ (Glutaredoxin-like protein) NrdH BADSM9389_RS04845 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BADSM9389_RS04855 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) BADSM9389_RS04860 ENOG4108WMJ Protein of unknown function (DUF2002) BADSM9389_RS04865 ENOG4108RNS Exports L-alanine (By similarity) BADSM9389_RS04875 ENOG4108V62 Rhodanese domain protein BADSM9389_RS04880 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP BADSM9389_RS04885 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BADSM9389_RS04905 ENOG4107R1I NAD-dependent malic enzyme BADSM9389_RS04925 ENOG4105HVQ Regulatory factor of maltose metabolism BADSM9389_RS04935 ENOG4105VT2 5-hydroxyisourate hydrolase BADSM9389_RS04945 ENOG4105DFP Integrase BADSM9389_RS04960 ENOG4105BZ1 (ABC) transporter BADSM9389_RS04975 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) BADSM9389_RS04980 ENOG4108Z1B Cyclase dehydrase BADSM9389_RS04985 ENOG4105VDB UPF0125 protein BADSM9389_RS04990 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BADSM9389_RS04995 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) BADSM9389_RS05010 ENOG4108JU6 CBS domain protein BADSM9389_RS05015 ENOG4106KVJ cytochrome C assembly protein BADSM9389_RS05020 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY BADSM9389_RS05025 ENOG4105K5M 30s ribosomal protein S16 BADSM9389_RS05030 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) BADSM9389_RS05040 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) BADSM9389_RS05045 ENOG4105QP9 Protein of unknown function (DUF2799) BADSM9389_RS05050 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BADSM9389_RS05055 ENOG4105EHE chorismate mutase- prephenate dehydrogenase BADSM9389_RS05065 ENOG4105CQC Prephenate dehydratase BADSM9389_RS05070 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA BADSM9389_RS05075 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane BADSM9389_RS05080 ENOG4105C34 Pseudouridine synthase BADSM9389_RS05085 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase BADSM9389_RS05090 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BADSM9389_RS05120 ENOG4105CSH Transporter BADSM9389_RS05125 ENOG4105T42 (LipO)protein BADSM9389_RS05130 ENOG4105JIM Phosphatidylserine synthase BADSM9389_RS05135 ENOG4105CD5 CoA-binding domain protein BADSM9389_RS05140 ENOG4106IUH DTW domain containing protein BADSM9389_RS05145 ENOG4105K63 Thioredoxin BADSM9389_RS05150 ENOG4105EIB trna rrna methyltransferase BADSM9389_RS05155 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) BADSM9389_RS05165 ENOG4105C1J atp-dependent rna helicase BADSM9389_RS05170 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) BADSM9389_RS05175 ENOG4108IYU L-aspartate oxidase BADSM9389_RS05195 ENOG4105VQK sigma E regulatory protein, MucB RseB BADSM9389_RS05200 ENOG4105WMJ Positive regulator of sigma E, RseC MucC BADSM9389_RS05205 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) BADSM9389_RS05210 ENOG4105C3F Signal peptidase i BADSM9389_RS05215 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) BADSM9389_RS05220 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) BADSM9389_RS05230 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) BADSM9389_RS05235 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) BADSM9389_RS05240 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding BADSM9389_RS05245 ENOG4106G6Q Transcriptional regulator BADSM9389_RS05250 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB BADSM9389_RS05255 ENOG4108Z6B deaminase BADSM9389_RS05260 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) BADSM9389_RS05265 ENOG4108ETH Formylglycinamide ribotide synthetase BADSM9389_RS05270 ENOG4107WP9 Histidine kinase BADSM9389_RS05275 ENOG4108SKK alpha helix protein BADSM9389_RS05280 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BADSM9389_RS05285 ENOG4108YZA Nitrogen regulatory protein pii BADSM9389_RS05290 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BADSM9389_RS05300 ENOG4108NZE NAGC-like transcriptional regulator BADSM9389_RS05305 ENOG4107HQ7 repeat protein BADSM9389_RS05310 ENOG4107QNK )-transporter BADSM9389_RS05315 ENOG4108ZKT aldose 1-epimerase BADSM9389_RS05320 ENOG4105D8G Major Facilitator superfamily BADSM9389_RS05325 ENOG4108MN2 Stationary phase inducible protein CsiE BADSM9389_RS05330 ENOG41065CD Exported protein BADSM9389_RS05335 ENOG4105D7X high-affinity nickel-transporter BADSM9389_RS05340 ENOG4105ECY inositol monophosphatase BADSM9389_RS05345 ENOG4105CVS RNA methyltransferase TrmH family, group 1 BADSM9389_RS05350 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family BADSM9389_RS05355 ENOG4105C3J Cysteine desulfurase BADSM9389_RS05360 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins BADSM9389_RS05380 ENOG4108ZIT Ferredoxin, 2FE-2S BADSM9389_RS05385 ENOG4105WVQ Fe-S assembly protein IscX BADSM9389_RS05390 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BADSM9389_RS05395 ENOG4105YYA enhanced serine sensitivity protein SseB BADSM9389_RS05400 ENOG4108Q3X Transcriptional regulator BADSM9389_RS05405 ENOG4105KHC sulfurtransferase BADSM9389_RS05415 ENOG4105CI1 PTS System BADSM9389_RS05420 ENOG4105DN3 alpha-2-macroglobulin domain protein BADSM9389_RS05425 ENOG4108JQB penicillin-binding protein 1C BADSM9389_RS05435 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs BADSM9389_RS05440 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) BADSM9389_RS05445 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) BADSM9389_RS05455 ENOG4105N21 Membrane BADSM9389_RS05460 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BADSM9389_RS05465 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) BADSM9389_RS05475 ENOG4107FQ9 ethanolamine ammonia-lyase BADSM9389_RS05480 ENOG4105CPD ethanolamine ammonia-lyase BADSM9389_RS05485 ENOG4105VPD cellular component movement BADSM9389_RS05490 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BADSM9389_RS05495 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) BADSM9389_RS05500 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) BADSM9389_RS05505 ENOG4105E2M Manganese-dependent inorganic pyrophosphatase BADSM9389_RS05510 ENOG41062G3 Protein of unknown function (DUF2633) BADSM9389_RS05515 ENOG4105BZU Histidine kinase BADSM9389_RS05520 ENOG4105C9X ppx gppa phosphatase BADSM9389_RS05525 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) BADSM9389_RS05530 ENOG4108V3E phosphoribosylglycinamide formyltransferase BADSM9389_RS05535 ENOG4105CXB phosphoribosylaminoimidazole synthetase BADSM9389_RS05540 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) BADSM9389_RS05545 ENOG4105C2W permease BADSM9389_RS05550 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) BADSM9389_RS05555 ENOG4105K89 arsenate reductase BADSM9389_RS05560 ENOG4105ERG peptidase m48, ste24p BADSM9389_RS05565 ENOG4105C02 permease BADSM9389_RS05570 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BADSM9389_RS05575 ENOG4105RH4 Glycine cleavage system transcriptional repressor BADSM9389_RS05585 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) BADSM9389_RS05590 ENOG4105C8V SAICAR synthetase BADSM9389_RS05595 ENOG4105CGZ zinc metallopeptidase BADSM9389_RS05600 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) BADSM9389_RS05605 ENOG4106KED esterase YpfH BADSM9389_RS05610 ENOG4105XYK UPF0370 protein BADSM9389_RS05615 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) BADSM9389_RS05620 ENOG4105KUZ arsenate reductase BADSM9389_RS05630 ENOG4105BZS acriflavin resistance protein BADSM9389_RS05635 ENOG4105WH1 Two component transcriptional regulator luxr family BADSM9389_RS05640 ENOG4105BZU Histidine kinase BADSM9389_RS05645 ENOG4105BZ8 glutamate synthase BADSM9389_RS05650 ENOG4108ZNS ferredoxin-type protein NapF BADSM9389_RS05655 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase BADSM9389_RS05660 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) BADSM9389_RS05665 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) BADSM9389_RS05670 ENOG4105CUW cytochrome C-TYPE protein BADSM9389_RS05675 ENOG4107VIJ nudix hydrolase BADSM9389_RS05680 ENOG4108PVD exported protein BADSM9389_RS05685 ENOG4105CV1 Transketolase (EC 2.2.1.1) BADSM9389_RS05690 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BADSM9389_RS05695 ENOG4105C6K Malic enzyme BADSM9389_RS05700 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) BADSM9389_RS05705 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase BADSM9389_RS05710 ENOG4108R6G acetyltransferase BADSM9389_RS05715 ENOG4105QZU Inner membrane protein YfeZ BADSM9389_RS05720 ENOG4105E7K (LipO)protein BADSM9389_RS05725 ENOG4105EZR dyp-type peroxidase family protein BADSM9389_RS05730 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein BADSM9389_RS05735 ENOG4108I5D sulfate abc transporter BADSM9389_RS05740 ENOG4105ECW sulfate abc transporter BADSM9389_RS05745 ENOG4108IJ6 ABC transporter BADSM9389_RS05750 ENOG4105C6T cysteine synthase BADSM9389_RS05755 ENOG4105C5Y PTS System BADSM9389_RS05760 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BADSM9389_RS05770 ENOG4105C6T cysteine synthase BADSM9389_RS05780 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) BADSM9389_RS05790 ENOG4105VRT cytoplasmic protein BADSM9389_RS05795 ENOG4105DHU Bile acid BADSM9389_RS05800 ENOG4108M0I Transcriptional regulator BADSM9389_RS05830 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) BADSM9389_RS05835 ENOG4105HZG regulatoR BADSM9389_RS05850 ENOG4108KMM Diguanylate cyclase BADSM9389_RS05860 ENOG4105D9N nucleoside BADSM9389_RS05870 ENOG4109076 Conserved Protein BADSM9389_RS05875 ENOG4105CPC Aldo Keto reductase BADSM9389_RS05880 ENOG4107RA9 decarboxylase BADSM9389_RS05885 ENOG4105VCT ion-transport protein YfeO BADSM9389_RS05895 ENOG4105DY9 regulatoR BADSM9389_RS05900 ENOG4108HRK Histidine kinase BADSM9389_RS05905 ENOG41072TH Protein of unknown function (DUF1479) BADSM9389_RS05910 ENOG4105CHM Aminotransferase BADSM9389_RS05925 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) BADSM9389_RS05935 ENOG4105E7W lamb ycsf family protein BADSM9389_RS05975 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme BADSM9389_RS06020 ENOG4105S64 Formate nitrite transporter BADSM9389_RS06030 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) BADSM9389_RS06035 ENOG41060IM Heme exporter protein BADSM9389_RS06040 ENOG4105X3C heme exporter protein BADSM9389_RS06045 ENOG4108ZKK Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity) BADSM9389_RS06050 ENOG4105DA4 cytochrome c-type biogenesis protein BADSM9389_RS06055 ENOG4107QX9 Thiol disulfide interChange protein BADSM9389_RS06060 ENOG4105KWW Biogenesis protein BADSM9389_RS06065 ENOG410903C (LipO)protein BADSM9389_RS06070 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation BADSM9389_RS06075 ENOG4105KZW UPF0381 protein BADSM9389_RS06080 ENOG4105CHU acetyl-coa acetyltransferase BADSM9389_RS06085 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BADSM9389_RS06090 ENOG4108BY2 phosphohistidine phosphatase BADSM9389_RS06100 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) BADSM9389_RS06105 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase BADSM9389_RS06110 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) BADSM9389_RS06115 ENOG4105EJ9 Membrane BADSM9389_RS06120 ENOG4108BPE -transporting atpase BADSM9389_RS06125 ENOG4105MH2 YfcL protein BADSM9389_RS06130 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) BADSM9389_RS06135 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BADSM9389_RS06145 ENOG4106WZ1 flagella biosynthesis regulator BADSM9389_RS06155 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BADSM9389_RS06160 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) BADSM9389_RS06165 ENOG4105DQR SNARE associated Golgi BADSM9389_RS06170 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) BADSM9389_RS06175 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase BADSM9389_RS06180 ENOG4108S3P Sporulation domain protein BADSM9389_RS06185 ENOG4105E96 Colicin v production protein BADSM9389_RS06190 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase BADSM9389_RS06195 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase BADSM9389_RS06200 ENOG4105E89 ABC transporter BADSM9389_RS06205 ENOG4105E89 ABC transporter BADSM9389_RS06210 ENOG4105DSP amino acid AbC transporter BADSM9389_RS06215 ENOG4106YG3 ABC transporter BADSM9389_RS06220 ENOG4108JEH abc transporter atp-binding protein BADSM9389_RS06225 ENOG4105ECP epimerase BADSM9389_RS06230 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase BADSM9389_RS06235 ENOG4105CYM Glutathione S-transferase BADSM9389_RS06240 ENOG4108SHQ Glutathione S-transferase BADSM9389_RS06245 ENOG4108RE9 Phosphodiesterase BADSM9389_RS06250 ENOG4105PTV Nudix Hydrolase BADSM9389_RS06255 ENOG4105C6K Malic enzyme BADSM9389_RS06260 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) BADSM9389_RS06265 ENOG4105PQ6 UPF0208 membrane protein BADSM9389_RS06275 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 BADSM9389_RS06280 ENOG4107QWE )-transporter BADSM9389_RS06285 ENOG4105DK2 UPF0207 protein BADSM9389_RS06290 ENOG4105CHM Aminotransferase BADSM9389_RS06295 ENOG4107NQ8 LysR family Transcriptional regulator BADSM9389_RS06300 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain BADSM9389_RS06305 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BADSM9389_RS06310 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BADSM9389_RS06315 ENOG4105GKE subunit e BADSM9389_RS06320 ENOG4107QIZ NADH dehydrogenase BADSM9389_RS06325 ENOG4108IEH NADH dehydrogenase subunit g BADSM9389_RS06330 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) BADSM9389_RS06340 ENOG4107UFS subunit j BADSM9389_RS06345 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BADSM9389_RS06350 ENOG4105D65 subunit l BADSM9389_RS06355 ENOG4105C8S subunit m BADSM9389_RS06360 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) BADSM9389_RS06365 ENOG4105CVP deoxyribo-dipyrimidine photolyase BADSM9389_RS06370 ENOG4107QNR UPF0135 protein BADSM9389_RS06375 ENOG4105P4J Allophanate hydrolase, subunit 1 BADSM9389_RS06380 ENOG4107R7A Allophanate hydrolase subunit 2 BADSM9389_RS06395 ENOG4105BZN citrate synthase BADSM9389_RS06400 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit BADSM9389_RS06405 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein BADSM9389_RS06410 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) BADSM9389_RS06415 ENOG4105E33 succinate dehydrogenase BADSM9389_RS06420 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 BADSM9389_RS06425 ENOG4105C7S Dehydrogenase BADSM9389_RS06430 ENOG4105CMV Succinyl-CoA synthetase subunit beta BADSM9389_RS06435 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha BADSM9389_RS06450 ENOG4105CS6 Rhs element vgr protein BADSM9389_RS06455 ENOG4105FDP GntR family transcriptional regulator BADSM9389_RS06460 ENOG4105DM4 PTS System BADSM9389_RS06465 ENOG4105C8I hydrolase, family 38 BADSM9389_RS06470 ENOG4105C4M (Ubiquinol oxidase) subunit I BADSM9389_RS06475 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BADSM9389_RS06485 ENOG4105KJB cyd operon protein YbgE BADSM9389_RS06490 ENOG4107YD3 Thioesterase BADSM9389_RS06495 ENOG4105E02 MotA TolQ exbB proton channel BADSM9389_RS06505 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA BADSM9389_RS06515 ENOG4105KCK Peptidoglycan-associated lipoprotein BADSM9389_RS06520 ENOG4105UFD tol-pal system protein YbgF BADSM9389_RS06565 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) BADSM9389_RS06570 ENOG4106Z1T Nicotinamide Mononucleotide Transporter BADSM9389_RS06575 ENOG4105PGM cation diffusion facilitator family transporter BADSM9389_RS06580 ENOG4105JND homeobox protein BADSM9389_RS06585 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BADSM9389_RS06595 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) BADSM9389_RS06600 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) BADSM9389_RS06605 ENOG4105F0Z galactose-1-phosphate uridylyltransferase BADSM9389_RS06610 ENOG4105CMR udp-glucose 4-epimerase BADSM9389_RS06615 ENOG4105DKW ABC transporter BADSM9389_RS06620 ENOG4105F4R Transcriptional regulator mode BADSM9389_RS06630 ENOG4106BRA Membrane BADSM9389_RS06635 ENOG4105KT5 UmuD protein BADSM9389_RS06640 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BADSM9389_RS06645 ENOG4105BZU Histidine kinase BADSM9389_RS06655 ENOG4105E68 Sulfatase BADSM9389_RS06660 ENOG4105PAN UPF0352 protein BADSM9389_RS06665 ENOG4106V8H Nucleoid-associated protein BADSM9389_RS06670 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) BADSM9389_RS06675 ENOG4105CFI type iii restriction protein res subunit BADSM9389_RS06680 ENOG4105I08 Pseudouridine synthase BADSM9389_RS06685 ENOG4105C2C drug resistance transporter, Bcr CflA BADSM9389_RS06690 ENOG4105HG6 BADSM9389_RS06695 ENOG4108JQ5 ABC transporter BADSM9389_RS06700 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component BADSM9389_RS06705 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component BADSM9389_RS06710 ENOG4105E43 Extracellular solute-binding protein, family 5 BADSM9389_RS06715 ENOG4105CXC rtn protein BADSM9389_RS06720 ENOG4107TT5 NLP P60 protein BADSM9389_RS06725 ENOG41076MN Phosphoesterase, PA-phosphatase related BADSM9389_RS06730 ENOG4105CKI cobalamin synthesis protein BADSM9389_RS06735 ENOG4105DEI Mannitol dehydrogenase BADSM9389_RS06740 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) BADSM9389_RS06750 ENOG4105J0Q Transcriptional regulator BADSM9389_RS06760 ENOG4105KRS Proteinase inhibitor BADSM9389_RS06765 ENOG4105S8Q sugar efflux transporter BADSM9389_RS06770 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein BADSM9389_RS06775 ENOG4105DE4 1-phosphofructokinase BADSM9389_RS06780 ENOG4105DM4 PTS System BADSM9389_RS06785 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) BADSM9389_RS06790 ENOG4105HMI Membrane BADSM9389_RS06795 ENOG4105DUM transcriptional regulator, lysR family BADSM9389_RS06800 ENOG4105QYK bacteriophage lambda Bor protein homolog BADSM9389_RS06810 ENOG4108IQI permease BADSM9389_RS06815 ENOG4105D05 Receptor BADSM9389_RS06825 ENOG4105CBP Major Facilitator BADSM9389_RS06830 ENOG4105EUJ GTP cyclohydrolase i BADSM9389_RS06835 ENOG4105DHF Membrane BADSM9389_RS06840 ENOG41060NJ transcriptional regulator BADSM9389_RS06850 ENOG4105C2J ABC transporter BADSM9389_RS06855 ENOG4107SDZ Galactoside transport system permease protein mglC BADSM9389_RS06860 ENOG4107GZ4 SanA protein BADSM9389_RS06865 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) BADSM9389_RS06870 ENOG41067MG lrgb family BADSM9389_RS06880 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BADSM9389_RS06885 ENOG4105C5H ABC transporter BADSM9389_RS06895 ENOG4105DPW Major facilitator superfamily MFS_1 BADSM9389_RS06900 ENOG4105ETE Transcriptional regulator (LacI family BADSM9389_RS06905 ENOG4105D06 uba thif-type nad fad binding protein BADSM9389_RS06910 ENOG4105CVM Molybdenum cofactor synthesis domain protein BADSM9389_RS06915 ENOG4105D44 asparaginase BADSM9389_RS06920 ENOG4108JQ6 ABC transporter BADSM9389_RS06925 ENOG4105DEF Extracellular solute-binding protein, family 5 BADSM9389_RS06940 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) BADSM9389_RS06950 ENOG4107R6D beta-lactam binding protein AmpH BADSM9389_RS06955 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway BADSM9389_RS06960 ENOG4105D8V Glucose sorbosone dehydrogenase BADSM9389_RS06965 ENOG4108TGY Glutathione S-transferase BADSM9389_RS06970 ENOG4105DZ1 carboxypeptidase BADSM9389_RS06975 ENOG4107FB0 transcriptional regulator DeoR family BADSM9389_RS06980 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase BADSM9389_RS06985 ENOG4107QF7 multi-drug BADSM9389_RS06990 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) BADSM9389_RS06995 ENOG4105D1F ATP-binding protein BADSM9389_RS07000 ENOG4108HRK Histidine kinase BADSM9389_RS07005 ENOG4108NEV two component transcriptional regulator, LytTR family BADSM9389_RS07010 ENOG4108W15 Protein of unknown function (DUF1456) BADSM9389_RS07015 ENOG4107XAN XdhC and CoxI family BADSM9389_RS07025 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding BADSM9389_RS07035 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding BADSM9389_RS07050 ENOG4105EGS Mechanosensitive ion channel BADSM9389_RS07055 ENOG4108WDE Fimbrial protein BADSM9389_RS07065 ENOG4108AF8 Chaperone BADSM9389_RS07070 ENOG4105CW0 outer membrane usher protein BADSM9389_RS07075 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) BADSM9389_RS07080 ENOG4108ZI2 Fimbrial protein BADSM9389_RS07085 ENOG4108Q9V regulatoR BADSM9389_RS07095 ENOG4106KCD HTH_LUXR BADSM9389_RS07100 ENOG4105BZU Histidine kinase BADSM9389_RS07230 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase BADSM9389_RS07235 ENOG4105DWF phosphomethylpyrimidine kinase BADSM9389_RS07240 ENOG4105FDP GntR family transcriptional regulator BADSM9389_RS07245 ENOG4108TFM Kinase, PfkB family BADSM9389_RS07250 ENOG4108KD5 ADP-ribosylation crystallin J1 BADSM9389_RS07255 ENOG4105EAA nucleoside BADSM9389_RS07260 ENOG4105EIE fructose-bisphosphate aldolase BADSM9389_RS07265 ENOG4105CXK mandelate racemase muconate lactonizing BADSM9389_RS07270 ENOG4105DEF Extracellular solute-binding protein, family 5 BADSM9389_RS07275 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BADSM9389_RS07280 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BADSM9389_RS07290 ENOG4108JQ7 (ABC) transporter BADSM9389_RS07305 ENOG4108D1K outer membrane usher protein BADSM9389_RS07315 ENOG4108VCD Chaperone BADSM9389_RS07330 ENOG4107TE5 Lipid kinase BADSM9389_RS07335 ENOG4105CFP Peptidase U32 BADSM9389_RS07340 ENOG4105E3W Two component transcriptional regulator (Winged helix family BADSM9389_RS07345 ENOG4105EB3 Histidine kinase BADSM9389_RS07350 ENOG4105C0R drug resistance transporter emrb qaca subfamily BADSM9389_RS07355 ENOG4105BZS acriflavin resistance protein BADSM9389_RS07360 ENOG4105BZS acriflavin resistance protein BADSM9389_RS07380 ENOG4105R8A Heat shock protein BADSM9389_RS07385 ENOG4105D03 DNA-3-methyladenine glycosylase II BADSM9389_RS07390 ENOG4105BZU Histidine kinase BADSM9389_RS07395 ENOG4105DBI uridine monophosphokinase BADSM9389_RS07400 ENOG4105DHP deoxycytidine triphosphate deaminase BADSM9389_RS07405 ENOG4108GAE asmA family BADSM9389_RS07410 ENOG4105EE5 Membrane protein terC BADSM9389_RS07415 ENOG4105DAY polysaccharide export protein BADSM9389_RS07420 ENOG4105KJF protein tyrosine phosphatase BADSM9389_RS07425 ENOG4105D75 Capsular exopolysaccharide family BADSM9389_RS07430 ENOG41090RK glycosyl transferase BADSM9389_RS07435 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB BADSM9389_RS07440 ENOG4107RXY Glycosyl transferase BADSM9389_RS07445 ENOG4108NYJ Colanic acid BADSM9389_RS07450 ENOG4105ECJ Glycosyl Transferase BADSM9389_RS07455 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF BADSM9389_RS07460 ENOG4105C0K Gdp-mannose 4,6-dehydratase BADSM9389_RS07465 ENOG4105C30 Nad-dependent epimerase dehydratase BADSM9389_RS07470 ENOG4105FGF GDP-mannose mannosyl hydrolase BADSM9389_RS07475 ENOG4106CD9 glycosyl transferase group 1 BADSM9389_RS07480 ENOG4105CJT Mannose-1-phosphate guanylyltransferase BADSM9389_RS07485 ENOG4107QKV phosphomannomutase BADSM9389_RS07490 ENOG4105D3Q Sugar transferase BADSM9389_RS07495 ENOG4105PSV Polysaccharide Biosynthesis Protein BADSM9389_RS07500 ENOG4105C74 pyruvyl transferase BADSM9389_RS07505 ENOG4107T8Q Glycosyl transferase (Group 1 BADSM9389_RS07510 ENOG4105G1A colanic acid biosynthesis protein BADSM9389_RS07515 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BADSM9389_RS07520 ENOG4105ER6 polysaccharide biosynthesis protein BADSM9389_RS07525 ENOG4105ECJ Glycosyl Transferase BADSM9389_RS07545 ENOG4105C0K Gdp-mannose 4,6-dehydratase BADSM9389_RS07550 ENOG4105C30 Nad-dependent epimerase dehydratase BADSM9389_RS07555 ENOG4105FGF GDP-mannose mannosyl hydrolase BADSM9389_RS07575 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) BADSM9389_RS07580 ENOG4105C1B dTDP-glucose 4-6-dehydratase BADSM9389_RS07585 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) BADSM9389_RS07590 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) BADSM9389_RS07610 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) BADSM9389_RS07615 ENOG4105ECC imidazole-glycerol-phosphate dehydratase BADSM9389_RS07620 ENOG4105CIH Imidazole acetol-phosphate transaminase BADSM9389_RS07630 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) BADSM9389_RS07640 ENOG4107SRH Nad-dependent epimerase dehydratase BADSM9389_RS07645 ENOG4105EQ1 Transcriptional regulator BADSM9389_RS07650 ENOG4108JPW Aminotransferase BADSM9389_RS07660 ENOG4105CUB amino acid BADSM9389_RS07665 ENOG4105CJB Exodeoxyribonuclease I BADSM9389_RS07670 ENOG4105DZ1 carboxypeptidase BADSM9389_RS07675 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) BADSM9389_RS07680 ENOG4105DR8 Membrane BADSM9389_RS07685 ENOG41090HJ UPF0265 protein BADSM9389_RS07690 ENOG4105JZC GHMP kinase BADSM9389_RS07695 ENOG4105C0Y Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BADSM9389_RS07700 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) BADSM9389_RS07705 ENOG41081F0 Precorrin-8x methylmutase BADSM9389_RS07710 ENOG4105EE8 May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity) BADSM9389_RS07715 ENOG4108DR9 Cobalt-precorrin-6Y C(5)-methyltransferase BADSM9389_RS07720 ENOG4107XSI cobalt-precorrin-6y C15-methyltransferase BADSM9389_RS07725 ENOG4105CIA precorrin-4 C(11)-methyltransferase BADSM9389_RS07730 ENOG4108P62 biosynthesis protein (CbiG) BADSM9389_RS07735 ENOG4105E4R Precorrin-3B C17-methyltransferase BADSM9389_RS07740 ENOG4105QUC reductase BADSM9389_RS07745 ENOG4107PPM cobalt chelatase BADSM9389_RS07750 ENOG4105DVK Precorrin-2 c20-methyltransferase BADSM9389_RS07755 ENOG4105CFT Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) BADSM9389_RS07760 ENOG4105W4R Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity) BADSM9389_RS07765 ENOG4108V4M Cobalt abc transporter BADSM9389_RS07775 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) BADSM9389_RS07780 ENOG4108YZT Adenosylcobinamide kinase BADSM9389_RS07790 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) BADSM9389_RS07795 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family BADSM9389_RS07810 ENOG4105EFP binding-protein-dependent transport systems inner membrane Component BADSM9389_RS07830 ENOG4105BZU Histidine kinase BADSM9389_RS07835 ENOG4108UY2 Chloramphenicol acetyltransferase BADSM9389_RS07840 ENOG4108V06 Glutathione peroxidase BADSM9389_RS07845 ENOG4105D3G Pseudouridine synthase BADSM9389_RS07860 ENOG4105C32 Amino acid ABC transporter (Permease) BADSM9389_RS07865 ENOG4105CF8 branched-chain amino acid ABC transporter, permease BADSM9389_RS07870 ENOG4105C0Z ABC transporter BADSM9389_RS07875 ENOG4108IV0 ABC, transporter BADSM9389_RS07880 ENOG4105UQX Mate efflux family protein BADSM9389_RS07885 ENOG4105CFC Transporter BADSM9389_RS07890 ENOG4105EJC lysr family transcriptional regulator BADSM9389_RS07895 ENOG4105CIS alcohol dehydrogenase BADSM9389_RS07900 ENOG4108RCM Nitroreductase BADSM9389_RS07905 ENOG41067V3 Antibiotic biosynthesis monooxygenase BADSM9389_RS07910 ENOG4105JQN Transcriptional regulator BADSM9389_RS07915 ENOG4105C0R drug resistance transporter emrb qaca subfamily BADSM9389_RS07945 ENOG4105DC7 peptidase M24 BADSM9389_RS07950 ENOG4105FYV Amp nucleosidase BADSM9389_RS07970 ENOG4108SGR YheO domain-containing protein BADSM9389_RS07980 ENOG4105C7B Threonine dehydratase BADSM9389_RS07985 ENOG41061EV selenium-binding protein YdfZ BADSM9389_RS08010 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) BADSM9389_RS08020 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen BADSM9389_RS08030 ENOG4107R11 Transcriptional regulator BADSM9389_RS08035 ENOG4108PXI ErfK YbiS YcfS YnhG BADSM9389_RS08045 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) BADSM9389_RS08050 ENOG4105FCK Membrane BADSM9389_RS08060 ENOG4105EST Metal Dependent Phosphohydrolase BADSM9389_RS08075 ENOG41090BB DNA mismatch endonuclease (vsr) BADSM9389_RS08080 ENOG4105FDR Membrane BADSM9389_RS08085 ENOG4105CKW Inner membrane protein yedI BADSM9389_RS08090 ENOG4105VNZ cytoplasmic protein BADSM9389_RS08105 ENOG4105YX3 cellular response to acidity BADSM9389_RS08110 ENOG4105VZF DsrB protein BADSM9389_RS08115 ENOG4107TKS colanic acid capsular biosynthesis activation protein A BADSM9389_RS08120 ENOG4105D19 Role in flagellar biosynthesis (By similarity) BADSM9389_RS08130 ENOG4105CN7 Flagellar biosynthetic protein FliP BADSM9389_RS08135 ENOG4105K0P flagellar biosynthesis protein BADSM9389_RS08140 ENOG4105DD5 Flagellar motor switch protein BADSM9389_RS08145 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BADSM9389_RS08150 ENOG4107ZI8 flagellar basal body-associated protein flil BADSM9389_RS08155 ENOG4105WF4 Flagellar hook-length control protein BADSM9389_RS08160 ENOG4105GSA Flagellar export protein flij BADSM9389_RS08165 ENOG4108JIR Flagellum-specific ATP synthase BADSM9389_RS08170 ENOG41090PJ Flagellar assembly protein BADSM9389_RS08175 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) BADSM9389_RS08180 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) BADSM9389_RS08185 ENOG4105VQ0 flagellar hook-basal body complex protein fliE BADSM9389_RS08190 ENOG4105JCU Inherit from NOG: (Lipo)protein BADSM9389_RS08195 ENOG4105E5K Alpha-amylase BADSM9389_RS08205 ENOG4105MQ3 flagellar protein FliS BADSM9389_RS08210 ENOG4105DTS flagellar hook-associated BADSM9389_RS08215 ENOG4105I03 Flagellin BADSM9389_RS08220 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BADSM9389_RS08225 ENOG4108M9K flagella biosynthesis protein FliZ BADSM9389_RS08230 ENOG4105EAB amino acid AbC transporter BADSM9389_RS08235 ENOG4105K6H D-cysteine desulfhydrase BADSM9389_RS08240 ENOG4105E5Q amino acid AbC transporter BADSM9389_RS08245 ENOG4105CDA abc transporter atp-binding protein BADSM9389_RS08250 ENOG4105VJY transcriptional regulator BADSM9389_RS08255 ENOG4105XVG cytoplasmic protein BADSM9389_RS08260 ENOG4105WH1 Two component transcriptional regulator luxr family BADSM9389_RS08265 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) BADSM9389_RS08290 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate BADSM9389_RS08295 ENOG4108EKE The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in N-acetylmuramic acid (MurNAc) transport, yielding cytoplasmic MurNAc-6-P. Is also able to take up anhydro-N-acetylmuramic acid (anhMurNAc), but cannot phosphorylate the carbon 6, probably because of the 1,6-anhydro ring (By similarity) BADSM9389_RS08300 ENOG4106RHG Yeca family BADSM9389_RS08305 ENOG4105D3Q Sugar transferase BADSM9389_RS08345 ENOG4107RA4 Glycosyl transferase (Group 1 BADSM9389_RS08360 ENOG4105CMR udp-glucose 4-epimerase BADSM9389_RS08370 ENOG41090A1 ferritin BADSM9389_RS08380 ENOG4105C8Q Methyl-accepting chemotaxis BADSM9389_RS08390 ENOG4105C0R drug resistance transporter emrb qaca subfamily BADSM9389_RS08410 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BADSM9389_RS08415 ENOG4105C3U ABC transporter BADSM9389_RS08420 ENOG4108JQ7 (ABC) transporter BADSM9389_RS08435 ENOG4105N4N Protein of unknown function (DUF2766) BADSM9389_RS08440 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BADSM9389_RS08445 ENOG4105EY3 heparinase II III family protein BADSM9389_RS08455 ENOG4105E0S extracellular solute-binding protein family 1 BADSM9389_RS08465 ENOG4105DRS transport system, permease BADSM9389_RS08480 ENOG4108UEC Ferritin-like protein BADSM9389_RS08485 ENOG4105E7U AraC family transcriptional regulator BADSM9389_RS08495 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) BADSM9389_RS08500 ENOG4105EP8 Glycosyl Hydrolase Family 88 BADSM9389_RS08510 ENOG4108WC9 type VI secretion system effector, hcp1 family BADSM9389_RS08525 ENOG4105Q95 Cupin 2, conserved barrel domain protein BADSM9389_RS08530 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator BADSM9389_RS08540 ENOG4105CNN ABC, transporter BADSM9389_RS08545 ENOG4108K4C ec 3.1.3.12 BADSM9389_RS08550 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase BADSM9389_RS08555 ENOG4108VA4 Universal stress protein BADSM9389_RS08560 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) BADSM9389_RS08565 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region BADSM9389_RS08570 ENOG4107RD7 Flagellar Motor Protein, MotA BADSM9389_RS08575 ENOG4105ER2 Ompa motb domain protein BADSM9389_RS08580 ENOG4105CBS Chea signal transduction histidine kinase BADSM9389_RS08585 ENOG4108V3W Chemotaxis protein, CheW BADSM9389_RS08590 ENOG4107QJT sodium dicarboxylate symporter BADSM9389_RS08620 ENOG4105C8Q Methyl-accepting chemotaxis BADSM9389_RS08625 ENOG4105C8Q Methyl-accepting chemotaxis BADSM9389_RS08630 ENOG4105BZU Histidine kinase BADSM9389_RS08635 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) BADSM9389_RS08640 ENOG4108VYJ response regulator receiver protein BADSM9389_RS08645 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) BADSM9389_RS08670 ENOG4105D00 flagellar biosynthetic protein flhB BADSM9389_RS08675 ENOG4105D7B Flagellar biosynthesis protein flha BADSM9389_RS08680 ENOG4105IRD Flagellar protein FlhE BADSM9389_RS08685 ENOG4105CT4 transporter BADSM9389_RS08690 ENOG4105F5H Glycosyl Hydrolase Family 88 BADSM9389_RS08695 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BADSM9389_RS08700 ENOG4105C75 arginyL-tRNA synthetase BADSM9389_RS08705 ENOG4106ZCM YecM protein BADSM9389_RS08710 ENOG4105C87 Aminotransferase class I and II BADSM9389_RS08715 ENOG4106N3A copper homeostasis protein cutc BADSM9389_RS08720 ENOG4105RFR Protein of unknown function (DUF2767) BADSM9389_RS08725 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) BADSM9389_RS08735 ENOG4105WJG Glutathione BADSM9389_RS08740 ENOG41081XQ Conserved Protein BADSM9389_RS08745 ENOG4105D3W isochorismatase BADSM9389_RS08750 ENOG4105C9M aspartyl-trna synthetase BADSM9389_RS08755 ENOG4108TIT dATP pyrophosphohydrolase BADSM9389_RS08760 ENOG4105CDY transcriptional regulatory protein BADSM9389_RS08765 ENOG4105NHU Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity) BADSM9389_RS08770 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) BADSM9389_RS08780 ENOG4105FAV ABC, transporter BADSM9389_RS08790 ENOG4105NXV High-affinity zinc uptake system protein BADSM9389_RS08795 ENOG4105DR5 peptidase BADSM9389_RS08800 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase BADSM9389_RS08805 ENOG4105CA9 Pyruvate kinase BADSM9389_RS08810 ENOG4106KNT transcriptional regulator BADSM9389_RS08815 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase BADSM9389_RS08820 ENOG4105C01 Dihydroxy-acid dehydratase BADSM9389_RS08825 ENOG4108UHU Aldolase BADSM9389_RS08830 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR BADSM9389_RS08835 ENOG4105X2V dna damage-inducible protein BADSM9389_RS08840 ENOG4108Q2J Inner membrane protein YebE BADSM9389_RS08845 ENOG4105CUG Oligopeptidase b BADSM9389_RS08850 ENOG4105UMD exodeoxyribonuclease X BADSM9389_RS08860 ENOG4105MPK DNA polymerase III subunit theta BADSM9389_RS08865 ENOG4105FXM Copper resistance protein BADSM9389_RS08870 ENOG4108PNC copper resistance BADSM9389_RS08875 ENOG4105NKT exported protein BADSM9389_RS08885 ENOG4105CHH sulfate transporter BADSM9389_RS08895 ENOG4108R1E Serine threonine protein phosphatase 1 BADSM9389_RS08900 ENOG4105UVW uncharacterized protein yebW BADSM9389_RS08905 ENOG4105WT8 Protein of unknown function (DUF1480) BADSM9389_RS08915 ENOG4105DY2 Paraquat-inducible protein b BADSM9389_RS08920 ENOG4105H2K paraquat-inducible protein a BADSM9389_RS08925 ENOG4108ZGC gaf domain protein BADSM9389_RS08930 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) BADSM9389_RS08935 ENOG4105CN1 protease BADSM9389_RS08940 ENOG4105D0M Protease HtpX homolog BADSM9389_RS08945 ENOG4105C0R drug resistance transporter emrb qaca subfamily BADSM9389_RS08950 ENOG4105J4Q Transcriptional regulator BADSM9389_RS08955 ENOG4105TIK BADSM9389_RS08960 ENOG4106CCY Protein MgrB homolog BADSM9389_RS08965 ENOG4105Q3Y exported protein BADSM9389_RS08980 ENOG4105CJN penicillin-binding protein BADSM9389_RS08985 ENOG4105DHI Methyltransferase BADSM9389_RS08990 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) BADSM9389_RS09000 ENOG4105F3R pts system mannose fructose sorbose family iid BADSM9389_RS09005 ENOG4105ETZ PTS System BADSM9389_RS09010 ENOG4105DAS pts system BADSM9389_RS09015 ENOG4105EE5 Membrane protein terC BADSM9389_RS09020 ENOG4107XTP (EAL) domain protein BADSM9389_RS09030 ENOG4105DJB Major Facilitator Superfamily BADSM9389_RS09035 ENOG4106KR7 LysR family Transcriptional regulator BADSM9389_RS09040 ENOG4105EJQ L-serine dehydratase BADSM9389_RS09045 ENOG4105P8F nudix hydrolase BADSM9389_RS09050 ENOG4105CRQ synthase (Component I) BADSM9389_RS09055 ENOG4105X5C UPF0181 protein BADSM9389_RS09060 ENOG4105M4H endoribonuclease L-psp BADSM9389_RS09065 ENOG4105DVT helicase BADSM9389_RS09070 ENOG41072GX Peptidase M22 Glycoprotease BADSM9389_RS09075 ENOG4105Y4Z Outer Membrane Lipoprotein BADSM9389_RS09080 ENOG4105CEY Amp-dependent synthetase and ligase BADSM9389_RS09090 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) BADSM9389_RS09095 ENOG4107QMS site-determining protein BADSM9389_RS09100 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) BADSM9389_RS09105 ENOG4105VNG YcgL domain-containing protein BADSM9389_RS09110 ENOG4105CVE Lytic murein transglycosylase BADSM9389_RS09115 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase BADSM9389_RS09125 ENOG41064RH membrane protein YliF BADSM9389_RS09130 ENOG4105UCG Domain of unknown function (DUF333) BADSM9389_RS09135 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) BADSM9389_RS09145 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) BADSM9389_RS09150 ENOG4105ED1 spovr family BADSM9389_RS09160 ENOG4105MWK D-amino acid dehydrogenase, small subunit BADSM9389_RS09175 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A BADSM9389_RS09180 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division BADSM9389_RS09185 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) BADSM9389_RS09195 ENOG4107WCA isomerase BADSM9389_RS09200 ENOG4107W6W Conserved Protein BADSM9389_RS09205 ENOG4105CQ4 Transcriptional regulator BADSM9389_RS09210 ENOG4105CNT hydrolase family 2 BADSM9389_RS09215 ENOG4105FK9 beta-D-galactosidase beta subunit BADSM9389_RS09220 ENOG4105E5D amino acid BADSM9389_RS09225 ENOG4105E0K tonB-dependent siderophore receptor BADSM9389_RS09230 ENOG4105E53 ec 3.2.1.28 BADSM9389_RS09235 ENOG4108AHD Transcriptional regulator BADSM9389_RS09240 ENOG4107RUZ Sss sodium solute transporter superfamily BADSM9389_RS09245 ENOG4105CBG Sulfatase BADSM9389_RS09250 ENOG4105VG5 Membrane BADSM9389_RS09255 ENOG4105JP4 Inner membrane protein yidG BADSM9389_RS09260 ENOG4105C4X radical SAM domain protein BADSM9389_RS09265 ENOG4105D9P serine threonine protein kinase BADSM9389_RS09280 ENOG4105C2X Arabinose 5-phosphate isomerase BADSM9389_RS09285 ENOG4108JDX DNA polymerase iii, epsilon subunit BADSM9389_RS09290 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) BADSM9389_RS09295 ENOG4108MEK Metal-binding protein YodA BADSM9389_RS09310 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon BADSM9389_RS09315 ENOG4108VCD Chaperone BADSM9389_RS09320 ENOG4105CW0 outer membrane usher protein BADSM9389_RS09340 ENOG4108JPW Aminotransferase BADSM9389_RS09345 ENOG4105C26 Dehydrogenase BADSM9389_RS09350 ENOG4105E5D amino acid BADSM9389_RS09365 ENOG4105C26 Dehydrogenase BADSM9389_RS09385 ENOG4106PH7 chaperone BADSM9389_RS09390 ENOG4106EAR Fimbrial protein BADSM9389_RS09400 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) BADSM9389_RS09405 ENOG4105CW0 outer membrane usher protein BADSM9389_RS09410 ENOG4108AF8 Chaperone BADSM9389_RS09430 ENOG41064T2 transcriptional regulator, lysR family BADSM9389_RS09440 ENOG4105C7W Xanthine dehydrogenase BADSM9389_RS09445 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding BADSM9389_RS09450 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit BADSM9389_RS09455 ENOG4108NS2 receptor BADSM9389_RS09465 ENOG4105CYX Short-chain dehydrogenase reductase Sdr BADSM9389_RS09470 ENOG4108UZ3 Transporter BADSM9389_RS09475 ENOG4105DIJ Phosphoethanolamine transferase BADSM9389_RS09480 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BADSM9389_RS09485 ENOG4105CKK Glycosyl transferase, family 2 BADSM9389_RS09490 ENOG4105C3I Nad-dependent epimerase dehydratase BADSM9389_RS09495 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) BADSM9389_RS09500 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) BADSM9389_RS09505 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) BADSM9389_RS09510 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) BADSM9389_RS09515 ENOG4105DUX Transporter BADSM9389_RS09530 ENOG4105KBH arsR family transcriptional regulator BADSM9389_RS09535 ENOG4105CAU Arsenical resistance protein, ArsH BADSM9389_RS09540 ENOG4108Z9Z response to DNA damage stimulus BADSM9389_RS09560 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component BADSM9389_RS09565 ENOG4105BZU Histidine kinase BADSM9389_RS09570 ENOG4108XDN Transcriptional regulator BADSM9389_RS09575 ENOG4106NZI LysR family Transcriptional regulator BADSM9389_RS09580 ENOG4105DR8 Membrane BADSM9389_RS09585 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BADSM9389_RS09600 ENOG4108PNB DNA-binding transcriptional regulator BADSM9389_RS09605 ENOG4108PNB DNA-binding transcriptional regulator BADSM9389_RS09615 ENOG4108NAE Fimbrial chaperone protein BADSM9389_RS09620 ENOG4105CW0 outer membrane usher protein BADSM9389_RS09655 ENOG4108R6K riboflavin synthase, subunit alpha BADSM9389_RS09660 ENOG4105DDV Transcriptional regulator (LacI family BADSM9389_RS09665 ENOG4105CS2 ec 3.2.1.21 BADSM9389_RS09670 ENOG4105CK1 PTS System BADSM9389_RS09675 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase BADSM9389_RS09680 ENOG4105CZQ inner membrane transport protein YdhC BADSM9389_RS09685 ENOG4105F52 Transcriptional regulator BADSM9389_RS09690 ENOG4105ETE Transcriptional regulator (LacI family BADSM9389_RS09700 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BADSM9389_RS09705 ENOG4105K4H Nlp p60 protein BADSM9389_RS09710 ENOG4105M2J Glutaredoxin BADSM9389_RS09715 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) BADSM9389_RS09720 ENOG4108UYE Lactoylglutathione lyase BADSM9389_RS09725 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase BADSM9389_RS09730 ENOG4108WUH Transcriptional regulator, TetR family BADSM9389_RS09740 ENOG4105XZD Fe-S protein BADSM9389_RS09745 ENOG4107RGM aldo keto reductase BADSM9389_RS09750 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) BADSM9389_RS09755 ENOG4105DSW Fusaric acid resistance protein BADSM9389_RS09760 ENOG4105Y49 secretion protein, HlyD family BADSM9389_RS09775 ENOG4108XTF Outer Membrane Lipoprotein BADSM9389_RS09780 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) BADSM9389_RS09785 ENOG410642K Lysozyme inhibitor BADSM9389_RS09790 ENOG4108S7T Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity) BADSM9389_RS09795 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) BADSM9389_RS09805 ENOG4108K3A Glutathione S-transferase BADSM9389_RS09810 ENOG4105DUX Transporter BADSM9389_RS09815 ENOG4105CSM endonuclease III BADSM9389_RS09825 ENOG4108UQQ Electron transport complex BADSM9389_RS09830 ENOG4105D6A Electron transport complex BADSM9389_RS09845 ENOG4105DGN Electron transport complex BADSM9389_RS09850 ENOG4105M9B inner membrane protein ydgK BADSM9389_RS09855 ENOG4105QZ5 OriC-binding nucleoid-associated protein BADSM9389_RS09860 ENOG4105D9R oxidoreductase BADSM9389_RS09865 ENOG4108MK9 spermidine N(1)-acetyltransferase BADSM9389_RS09870 ENOG4105M5Q UPF0482 protein BADSM9389_RS09875 ENOG4105KK4 UPF0060 membrane protein BADSM9389_RS09880 ENOG4105CXK mandelate racemase muconate lactonizing BADSM9389_RS09885 ENOG4105CPQ Dehydrogenase BADSM9389_RS09895 ENOG4105DEI Mannitol dehydrogenase BADSM9389_RS09900 ENOG4107XBN GntR Family Transcriptional Regulator BADSM9389_RS09905 ENOG4105EMU Dehydrogenase BADSM9389_RS09910 ENOG4107QUY Guanine deaminase BADSM9389_RS09920 ENOG4105CE2 Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding BADSM9389_RS09930 ENOG4105DGW oligopeptidase A BADSM9389_RS09950 ENOG4108VCD Chaperone BADSM9389_RS09955 ENOG4105CW0 outer membrane usher protein BADSM9389_RS09970 ENOG4108ZXC Two component transcriptional regulator, luxr family BADSM9389_RS09980 ENOG4108PNB DNA-binding transcriptional regulator BADSM9389_RS09990 ENOG4108VCD Chaperone BADSM9389_RS09995 ENOG4105CW0 outer membrane usher protein BADSM9389_RS10015 ENOG4105NAU thioesterase Superfamily protein BADSM9389_RS10030 ENOG4108S3I UPF0259 membrane protein BADSM9389_RS10035 ENOG4105EIF outer membrane protein W BADSM9389_RS10045 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) BADSM9389_RS10050 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) BADSM9389_RS10055 ENOG4105DK0 Indole-3-glycerol phosphate synthase BADSM9389_RS10060 ENOG4108EFP Anthranilate synthase component II BADSM9389_RS10065 ENOG4105CRQ synthase (Component I) BADSM9389_RS10070 ENOG4105DB7 PHP domain protein BADSM9389_RS10075 ENOG4107RTD sua5 ycio yrdc ywlc family protein BADSM9389_RS10080 ENOG4105FE9 pseudouridine synthase BADSM9389_RS10085 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase BADSM9389_RS10090 ENOG4105UBK short-chain dehydrogenase reductase BADSM9389_RS10095 ENOG4105ERU peptidase BADSM9389_RS10100 ENOG4105RKX Protein of unknown function (DUF2498) BADSM9389_RS10105 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BADSM9389_RS10110 ENOG4107R11 Transcriptional regulator BADSM9389_RS10125 ENOG4107QM5 aconitate hydratase BADSM9389_RS10130 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) BADSM9389_RS10135 ENOG4105EYK Phosphatidylglycerophosphatase B BADSM9389_RS10140 ENOG4105Q4A inner membrane protein yciS BADSM9389_RS10145 ENOG4105CFV Tetratricopeptide repeat protein BADSM9389_RS10150 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) BADSM9389_RS10155 ENOG4108ZJT translation initiation factor, Sui1 BADSM9389_RS10160 ENOG41061RM osmotically inducible lipoprotein BADSM9389_RS10165 ENOG4105N2W Transcriptional regulator BADSM9389_RS10175 ENOG4105F1A Pyruvate formate-lyase BADSM9389_RS10180 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BADSM9389_RS10185 ENOG4106BSC UPF0509 protein BADSM9389_RS10190 ENOG4105E39 Enoyl-CoA hydratase BADSM9389_RS10195 ENOG4107RSM transcriptional regulator BADSM9389_RS10205 ENOG4105BZU Histidine kinase BADSM9389_RS10210 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) BADSM9389_RS10215 ENOG4105Q4T oxidoreductase BADSM9389_RS10220 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH BADSM9389_RS10230 ENOG4108JQ2 peptide transport system atp-binding protein BADSM9389_RS10235 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein BADSM9389_RS10240 ENOG4108EU3 peptide transport system, permease BADSM9389_RS10245 ENOG4108EKA peptide transport system, permease BADSM9389_RS10250 ENOG4108J59 Extracellular solute-binding protein, family 5 BADSM9389_RS10255 ENOG4105E51 psp operon transcriptional activator BADSM9389_RS10260 ENOG41087YS Phage shock protein A BADSM9389_RS10265 ENOG4105YYT phage shock protein B BADSM9389_RS10270 ENOG4105FM1 phage shock protein C BADSM9389_RS10275 ENOG4105NNG Peripheral inner membrane phage-shock protein BADSM9389_RS10280 ENOG4107QW3 Sucrose phosphorylase BADSM9389_RS10285 ENOG4105WEM extracellular solute-binding protein BADSM9389_RS10290 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component BADSM9389_RS10295 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component BADSM9389_RS10300 ENOG4107RRD Dehydrogenase BADSM9389_RS10305 ENOG4107TYA transient receptor potential locus BADSM9389_RS10310 ENOG4105CK5 oxidoreductase BADSM9389_RS10315 ENOG4105C71 hydrolase family 65, central catalytic BADSM9389_RS10320 ENOG4107URF beta-phospho-glucomutase BADSM9389_RS10325 ENOG4108IJ9 (ABC) transporter BADSM9389_RS10330 ENOG4107EFV Outer membrane protein G BADSM9389_RS10335 ENOG4105FKQ transcriptional regulator BADSM9389_RS10340 ENOG4105CM6 amino acid regulated cytosolic protein BADSM9389_RS10345 ENOG4106K28 UPF0283 membrane protein BADSM9389_RS10350 ENOG4105E3S small subunit BADSM9389_RS10355 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BADSM9389_RS10360 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit BADSM9389_RS10365 ENOG4105DPX Hydrogenase, large subunit BADSM9389_RS10370 ENOG4108USZ hydrogenase BADSM9389_RS10375 ENOG4108WGS hydrogenase 2-specific chaperone BADSM9389_RS10380 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) BADSM9389_RS10385 ENOG41082MF Hydrogenase assembly chaperone hypC hupF BADSM9389_RS10390 ENOG4108JU8 Transcriptional regulator BADSM9389_RS10395 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) BADSM9389_RS10400 ENOG4107S8C mandelate racemase muconate lactonizing BADSM9389_RS10405 ENOG4105KXI murein peptide amidase A BADSM9389_RS10410 ENOG4107QSI ABC, transporter BADSM9389_RS10445 ENOG4105QYK bacteriophage lambda Bor protein homolog BADSM9389_RS10450 ENOG4105C1J atp-dependent rna helicase BADSM9389_RS10455 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase BADSM9389_RS10460 ENOG4105CPW cytochrome b561 BADSM9389_RS10480 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) BADSM9389_RS10495 ENOG4105RR0 Protein of unknown function (DUF2554) BADSM9389_RS10500 ENOG410814C multidrug resistance protein BADSM9389_RS10505 ENOG410802X bacteriophage n4 adsorption protein b BADSM9389_RS10510 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit BADSM9389_RS10515 ENOG4105QUW BADSM9389_RS10525 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii BADSM9389_RS10530 ENOG4105C4M (Ubiquinol oxidase) subunit I BADSM9389_RS10540 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family BADSM9389_RS10545 ENOG4108YYQ gCN5-related N-acetyltransferase BADSM9389_RS10560 ENOG4105KHA Glyoxalase Bleomycin resistance protein (Dioxygenase BADSM9389_RS10565 ENOG4107TYH extracellular solute-binding protein family 1 BADSM9389_RS10570 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BADSM9389_RS10575 ENOG4105D81 ABC transporter, permease BADSM9389_RS10580 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component BADSM9389_RS10585 ENOG4105C26 Dehydrogenase BADSM9389_RS10595 ENOG4105EFX secretion protein, HlyD family BADSM9389_RS10600 ENOG4105KK7 inner membrane protein YiaW BADSM9389_RS10605 ENOG410654E Membrane BADSM9389_RS10610 ENOG4105N5Z UPF0267 protein BADSM9389_RS10615 ENOG4105Z2P Protein of unknown function (DUF465) BADSM9389_RS10620 ENOG4105Q26 Siderophore-interacting protein BADSM9389_RS10630 ENOG4105C8Q Methyl-accepting chemotaxis BADSM9389_RS10635 ENOG4108KSB HipA-like N-terminal domain BADSM9389_RS10640 ENOG4105MHH HipA N-terminal domain protein BADSM9389_RS10645 ENOG4107A4G HTH_XRE BADSM9389_RS10650 ENOG4105DEN Luciferase family BADSM9389_RS10665 ENOG4105EAB amino acid AbC transporter BADSM9389_RS10675 ENOG4105E5Q amino acid AbC transporter BADSM9389_RS10680 ENOG4105CDA abc transporter atp-binding protein BADSM9389_RS10700 ENOG4105E0U tyrosine-specific transport protein BADSM9389_RS10710 ENOG4106P55 Transcriptional regulator BADSM9389_RS10715 ENOG4105F11 amine oxidase BADSM9389_RS10720 ENOG4105DXM phenylacetic acid degradation protein BADSM9389_RS10725 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit BADSM9389_RS10730 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit BADSM9389_RS10735 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit BADSM9389_RS10740 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit BADSM9389_RS10745 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BADSM9389_RS10750 ENOG4105E39 Enoyl-CoA hydratase BADSM9389_RS10755 ENOG4108UKI Enoyl-CoA hydratase BADSM9389_RS10760 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase BADSM9389_RS10765 ENOG4108ZJI phenylacetic acid degradation protein BADSM9389_RS10770 ENOG4105CHU acetyl-coa acetyltransferase BADSM9389_RS10775 ENOG4105DZS Phenylacetate-CoA ligase BADSM9389_RS10790 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein BADSM9389_RS10795 ENOG4108Z0R Transferase BADSM9389_RS10800 ENOG4108WFR AraC Family Transcriptional Regulator BADSM9389_RS10805 ENOG4105C26 Dehydrogenase BADSM9389_RS10810 ENOG4105F32 YngK protein BADSM9389_RS10815 ENOG4107QZV Type I secretion membrane fusion protein BADSM9389_RS10820 ENOG4108JJ6 Type I secretion system ATPase BADSM9389_RS10830 ENOG4107SEY Conserved Protein BADSM9389_RS10835 ENOG4108XDN Transcriptional regulator BADSM9389_RS10865 ENOG4105DEF Extracellular solute-binding protein, family 5 BADSM9389_RS10870 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BADSM9389_RS10880 ENOG4105CQ7 ATP-dependent helicase BADSM9389_RS10885 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) BADSM9389_RS10890 ENOG4105DY8 decarboxylase BADSM9389_RS10895 ENOG4108JPW Aminotransferase BADSM9389_RS10900 ENOG4105WXT Conserved Protein BADSM9389_RS10905 ENOG410689M (LipO)protein BADSM9389_RS10910 ENOG4107H52 Dicarboxylate transport BADSM9389_RS10915 ENOG4105C5I Dehydrogenase BADSM9389_RS10920 ENOG41090X5 Heat shock protein hslJ BADSM9389_RS10925 ENOG4105IKK cytoplasmic protein BADSM9389_RS10930 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) BADSM9389_RS10940 ENOG4108NS2 receptor BADSM9389_RS10945 ENOG4105C26 Dehydrogenase BADSM9389_RS10950 ENOG4105DKT Transcriptional regulator BADSM9389_RS10955 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BADSM9389_RS10965 ENOG4105C2J ABC transporter BADSM9389_RS10970 ENOG4105CNN ABC, transporter BADSM9389_RS10975 ENOG4108HHA Transketolase BADSM9389_RS10980 ENOG4108IUS Transketolase BADSM9389_RS10985 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BADSM9389_RS10995 ENOG4107DB1 DUF218 domain BADSM9389_RS11005 ENOG4105CG3 alpha amylase, catalytic region BADSM9389_RS11025 ENOG4107T3P ABC, transporter BADSM9389_RS11050 ENOG4105CK5 oxidoreductase BADSM9389_RS11055 ENOG4105EAA nucleoside BADSM9389_RS11060 ENOG4105ETE Transcriptional regulator (LacI family BADSM9389_RS11080 ENOG4105C8Q Methyl-accepting chemotaxis BADSM9389_RS11090 ENOG4105FFC UPF0187 protein BADSM9389_RS11110 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly BADSM9389_RS11135 ENOG4105CF7 AraC family transcriptional regulator BADSM9389_RS11155 ENOG4105C5Q Transcriptional regulator BADSM9389_RS11160 ENOG4105CFP Peptidase U32 BADSM9389_RS11165 ENOG4105BZU Histidine kinase BADSM9389_RS11170 ENOG4105DKK Benzoate BADSM9389_RS11175 ENOG4105ECQ AraC Family Transcriptional Regulator BADSM9389_RS11185 ENOG4108KKZ (LipO)protein BADSM9389_RS11190 ENOG4105HB7 Glyoxalase Bleomycin resistance protein (Dioxygenase BADSM9389_RS11195 ENOG41088CC tellurite resistance protein tehB BADSM9389_RS11200 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein BADSM9389_RS11205 ENOG4107WE3 acetyltransferase YdcK BADSM9389_RS11210 ENOG4108Z9I -acetyltransferase BADSM9389_RS11215 ENOG41061H0 Monooxygenase BADSM9389_RS11225 ENOG4105DJ9 glucan biosynthesis protein BADSM9389_RS11230 ENOG4105E89 ABC transporter BADSM9389_RS11235 ENOG4105CHM Aminotransferase BADSM9389_RS11245 ENOG4108KX4 response regulator BADSM9389_RS11250 ENOG4105BZU Histidine kinase BADSM9389_RS11255 ENOG4105CXY transporter BADSM9389_RS11260 ENOG4105C4Y ABC transporter BADSM9389_RS11265 ENOG4107RCV ABC transporter, permease BADSM9389_RS11270 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BADSM9389_RS11275 ENOG4105E32 cytoplasmic protein BADSM9389_RS11280 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta BADSM9389_RS11285 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha BADSM9389_RS11290 ENOG4105DDW LysR family Transcriptional regulator BADSM9389_RS11295 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase BADSM9389_RS11300 ENOG4105F2Z 3-oxoadipate enol-lactonase BADSM9389_RS11305 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase BADSM9389_RS11310 ENOG4105CHU acetyl-coa acetyltransferase BADSM9389_RS11315 ENOG4107QNJ CoA-transferase subunit B BADSM9389_RS11325 ENOG4107HP6 Transcriptional regulator BADSM9389_RS11330 ENOG4108DG9 Smr protein MutS2 BADSM9389_RS11335 ENOG4106KR7 LysR family Transcriptional regulator BADSM9389_RS11340 ENOG4105CH2 amidohydrolase BADSM9389_RS11345 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B BADSM9389_RS11350 ENOG4105CFC Transporter BADSM9389_RS11355 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BADSM9389_RS11360 ENOG4105DS0 Transcriptional regulator, Crp Fnr family BADSM9389_RS11365 ENOG4105Q9Y Universal stress protein BADSM9389_RS11380 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BADSM9389_RS11385 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) BADSM9389_RS11390 ENOG4105C5D exported protein BADSM9389_RS11395 ENOG4105D5Q Arginine ornithine antiporter BADSM9389_RS11400 ENOG410642E Short chain dehydrogenase BADSM9389_RS11405 ENOG4107EXC regulatoR BADSM9389_RS11410 ENOG4105JJR Histidine kinase BADSM9389_RS11415 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) BADSM9389_RS11420 ENOG4105C9Q fumarate hydratase class II BADSM9389_RS11425 ENOG4107GFK fumarate BADSM9389_RS11430 ENOG4105EIP mannose-6-phosphate isomerase BADSM9389_RS11435 ENOG4106J39 exported protein BADSM9389_RS11440 ENOG4105EUZ Beta-lactamase domain protein BADSM9389_RS11445 ENOG4107P2S Transcriptional regulator BADSM9389_RS11450 ENOG4105CI1 PTS System BADSM9389_RS11455 ENOG4105C87 Aminotransferase class I and II BADSM9389_RS11465 ENOG4105DHU Bile acid BADSM9389_RS11475 ENOG4105KBG Protein of unknown function (DUF1161) BADSM9389_RS11480 ENOG4107QY8 reductase BADSM9389_RS11485 ENOG4105QAX Iron-sulfur BADSM9389_RS11490 ENOG4107KGK dmso reductase anchor subunit BADSM9389_RS11495 ENOG4108NEM leader-binding protein dmsD BADSM9389_RS11500 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component BADSM9389_RS11505 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system BADSM9389_RS11510 ENOG4105E90 ABC transporter BADSM9389_RS11515 ENOG4108IJ8 ABC transporter BADSM9389_RS11520 ENOG4105CMQ Chloride channel BADSM9389_RS11525 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BADSM9389_RS11530 ENOG4105DAG ROK family BADSM9389_RS11535 ENOG4106NZI LysR family Transcriptional regulator BADSM9389_RS11540 ENOG4105D94 Major Facilitator Superfamily BADSM9389_RS11545 ENOG4105CTD carboxy-peptidase BADSM9389_RS11555 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap BADSM9389_RS11565 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) BADSM9389_RS11570 ENOG4105DSF transport protein BADSM9389_RS11575 ENOG4105WBD 4-oxalocrotonate tautomerase BADSM9389_RS11580 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase BADSM9389_RS11585 ENOG4105ETE Transcriptional regulator (LacI family BADSM9389_RS11595 ENOG4105C85 amino acid BADSM9389_RS11600 ENOG4105CHB tonB-dependent Receptor BADSM9389_RS11605 ENOG410822N TonB family BADSM9389_RS11610 ENOG4105K9H YciI-like protein BADSM9389_RS11625 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) BADSM9389_RS11630 ENOG4108W5H UPF0263 protein BADSM9389_RS11635 ENOG4105EYW Ion transport protein BADSM9389_RS11640 ENOG4108JQ7 (ABC) transporter BADSM9389_RS11645 ENOG4105C3U ABC transporter BADSM9389_RS11650 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component BADSM9389_RS11655 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component BADSM9389_RS11660 ENOG4108J59 Extracellular solute-binding protein, family 5 BADSM9389_RS11665 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein BADSM9389_RS11670 ENOG4105C0A alcohol dehydrogenase BADSM9389_RS11675 ENOG4107104 thymidine kinase BADSM9389_RS11685 ENOG4105C6Y Udp-glucose 6-dehydrogenase BADSM9389_RS11690 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase BADSM9389_RS11695 ENOG4105I93 response regulator BADSM9389_RS11700 ENOG4105D78 K07001 NTE family protein BADSM9389_RS11705 ENOG4105K5B UPF0225 protein BADSM9389_RS11710 ENOG4105CIY formyltetrahydrofolate deformylase BADSM9389_RS11725 ENOG41076YT nitrate reductase, gamma subunit BADSM9389_RS11730 ENOG4105R3A Nitrate reductase BADSM9389_RS11735 ENOG4108IUE nitrate reductase beta subunit BADSM9389_RS11740 ENOG4105CRU nitrate reductase, alpha subunit BADSM9389_RS11745 ENOG4105R9B Major Facilitator BADSM9389_RS11750 ENOG4108KHF Resistance protein BADSM9389_RS11755 ENOG4108K85 Transcriptional regulator BADSM9389_RS11760 ENOG4105DQQ Major facilitator superfamily MFS_1 BADSM9389_RS11765 ENOG4105BZU Histidine kinase BADSM9389_RS11770 ENOG4105WH1 Two component transcriptional regulator luxr family BADSM9389_RS11775 ENOG4105ID0 Putative invasin BADSM9389_RS11785 ENOG4107QZF nitrite reductase NADPH large subunit BADSM9389_RS11790 ENOG4105D7T ABC transporter BADSM9389_RS11810 ENOG41090EX DsrE family BADSM9389_RS11820 ENOG4108NH8 Cation transport protein BADSM9389_RS11825 ENOG4105WS7 Cation transport regulator BADSM9389_RS11830 ENOG4105EWV Sodium calcium exchanger membrane region BADSM9389_RS11835 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase BADSM9389_RS11840 ENOG41063JG Transcriptional regulator BADSM9389_RS11845 ENOG4108YY7 Invasion gene expression up-regulator SirB BADSM9389_RS11850 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) BADSM9389_RS11855 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) BADSM9389_RS11860 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) BADSM9389_RS11865 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) BADSM9389_RS11870 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) BADSM9389_RS11875 ENOG4105C5T Phosphoribosyl pyrophosphate synthase BADSM9389_RS11880 ENOG4105CHH sulfate transporter BADSM9389_RS11885 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria BADSM9389_RS11890 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) BADSM9389_RS11895 ENOG4105C3G gtp-binding protein BADSM9389_RS11905 ENOG4108VCD Chaperone BADSM9389_RS11910 ENOG4105CW0 outer membrane usher protein BADSM9389_RS11915 ENOG4108MDY Fimbrial BADSM9389_RS11940 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) BADSM9389_RS11945 ENOG4105CNT hydrolase family 2 BADSM9389_RS11950 ENOG4105ETE Transcriptional regulator (LacI family BADSM9389_RS11960 ENOG4105BZU Histidine kinase BADSM9389_RS11995 ENOG4105ETE Transcriptional regulator (LacI family BADSM9389_RS12010 ENOG4108R85 Short chain dehydrogenase BADSM9389_RS12015 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BADSM9389_RS12035 ENOG4105CA9 Pyruvate kinase BADSM9389_RS12045 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BADSM9389_RS12060 ENOG4105JRK feS assembly protein SufD BADSM9389_RS12065 ENOG4105C3K feS assembly ATPase SufC BADSM9389_RS12070 ENOG4105DIW FeS assembly protein SUFB BADSM9389_RS12075 ENOG4108Z4V iron-sulfur cluster assembly BADSM9389_RS12090 ENOG4108ZXC Two component transcriptional regulator, luxr family BADSM9389_RS12095 ENOG4105BZU Histidine kinase BADSM9389_RS12100 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) BADSM9389_RS12110 ENOG4105MVF Transcriptional regulator BADSM9389_RS12115 ENOG4105KA0 thioesterase Superfamily protein BADSM9389_RS12120 ENOG4105CQB FAD linked oxidase domain protein BADSM9389_RS12125 ENOG4105IPI Membrane BADSM9389_RS12140 ENOG4105CT4 transporter BADSM9389_RS12145 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) BADSM9389_RS12150 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) BADSM9389_RS12155 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) BADSM9389_RS12165 ENOG4107ENK receptor BADSM9389_RS12170 ENOG4106QJH hemin transport protein BADSM9389_RS12175 ENOG4107R4I Periplasmic binding protein BADSM9389_RS12180 ENOG4105EHG Permease protein BADSM9389_RS12185 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) BADSM9389_RS12200 ENOG41060NJ transcriptional regulator BADSM9389_RS12205 ENOG4108QBX (LipO)protein BADSM9389_RS12215 ENOG4108V06 Glutathione peroxidase BADSM9389_RS12230 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) BADSM9389_RS12235 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) BADSM9389_RS12250 ENOG41082NX 50s ribosomal protein l35 BADSM9389_RS12255 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) BADSM9389_RS12270 ENOG4108NE3 Salt-induced outer membrane protein BADSM9389_RS12275 ENOG4105DE4 1-phosphofructokinase BADSM9389_RS12280 ENOG4105P10 Uncharacterized protein ydiZ BADSM9389_RS12290 ENOG4107PN8 YfeABCD locus regulator BADSM9389_RS12295 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 BADSM9389_RS12300 ENOG4105CHR reductase BADSM9389_RS12305 ENOG4107K5X Membrane-bound metal-dependent hydrolase BADSM9389_RS12310 ENOG4108ETY sodium dicarboxylate symporter BADSM9389_RS12315 ENOG41082ND Uncharacterized protein yjcO BADSM9389_RS12320 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) BADSM9389_RS12325 ENOG4105CH6 catalase BADSM9389_RS12330 ENOG4105KKI DNA-binding transcriptional activator OsmE BADSM9389_RS12335 ENOG4107RA1 nh(3)-dependent nad( ) synthetase BADSM9389_RS12350 ENOG4105C84 Histidine ammonia-lyase BADSM9389_RS12355 ENOG4105CZE histidine utilization repressor BADSM9389_RS12360 ENOG41090B9 response to stress BADSM9389_RS12365 ENOG4107SYB Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BADSM9389_RS12370 ENOG4105CI2 imidazolone-5-propionate hydrolase BADSM9389_RS12380 ENOG4108SPG Periplasmic Protein BADSM9389_RS12390 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) BADSM9389_RS12395 ENOG4105C26 Dehydrogenase BADSM9389_RS12400 ENOG4105F4X arginine BADSM9389_RS12405 ENOG4105C8Y Acetylornithine aminotransferase BADSM9389_RS12410 ENOG4105CGK Exodeoxyribonuclease III BADSM9389_RS12420 ENOG4105VNH ABC transporter solute-binding protein BADSM9389_RS12425 ENOG4105CXZ ABC transporter, permease BADSM9389_RS12430 ENOG4108VGW abc transporter atp-binding protein BADSM9389_RS12435 ENOG4107RM6 sulfurtransferase BADSM9389_RS12440 ENOG4108T9J Cdp-alcohol phosphatidyltransferase BADSM9389_RS12445 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) BADSM9389_RS12450 ENOG4105M6F mutator MutT protein BADSM9389_RS12455 ENOG4105MTM Protein of unknown function (DUF1496) BADSM9389_RS12460 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) BADSM9389_RS12465 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) BADSM9389_RS12470 ENOG41069NU Nitroreductase BADSM9389_RS12475 ENOG4105D07 Signal peptide peptidase, SppA BADSM9389_RS12480 ENOG4105HDK L-asparaginase BADSM9389_RS12485 ENOG4108RWI nicotinamidase BADSM9389_RS12495 ENOG4105VUT cytoplasmic protein BADSM9389_RS12510 ENOG4105DSB aldose 1-epimerase BADSM9389_RS12515 ENOG4105CV8 reductase BADSM9389_RS12520 ENOG4105GNX MltA-interacting MipA family protein BADSM9389_RS12525 ENOG4105CYN Serine protein kinase BADSM9389_RS12535 ENOG4108KHP Diguanylate cyclase BADSM9389_RS12545 ENOG4108VMM UPF0756 membrane protein BADSM9389_RS12550 ENOG4105R1U AraC Family Transcriptional Regulator BADSM9389_RS12555 ENOG4105DJ2 Major Facilitator Superfamily BADSM9389_RS12560 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) BADSM9389_RS12565 ENOG4105EWC Purine nucleoside phosphorylase BADSM9389_RS12575 ENOG4105VPI YqaE family transport protein BADSM9389_RS12580 ENOG4105VEQ Cold shock protein BADSM9389_RS12585 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) BADSM9389_RS12590 ENOG4105Y50 Virulence Protein BADSM9389_RS12605 ENOG4108HMX isocitrate dehydrogenase (NADP) BADSM9389_RS12610 ENOG4108R99 pseudouridine synthase BADSM9389_RS12615 ENOG4108Z5K methylglyoxal synthase BADSM9389_RS12625 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) BADSM9389_RS12630 ENOG41075W9 High frequency lysogenization protein HflD homolog BADSM9389_RS12635 ENOG4107QTF adenylosuccinate lyase BADSM9389_RS12640 ENOG4105XJC Two component transcriptional regulator (Winged helix family BADSM9389_RS12650 ENOG4105EZE Cupin 4 family protein BADSM9389_RS12665 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) BADSM9389_RS12680 ENOG4105D38 putrescine abc transporter BADSM9389_RS12685 ENOG4107RUE extracellular solute-binding protein family 1 BADSM9389_RS12700 ENOG4105CS6 Rhs element vgr protein BADSM9389_RS12705 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) BADSM9389_RS12710 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) BADSM9389_RS12715 ENOG4105D60 lipoprotein releasing system transmembrane protein BADSM9389_RS12725 ENOG4105D60 lipoprotein releasing system transmembrane protein BADSM9389_RS12730 ENOG4105IQC Inner membrane protein YcfT BADSM9389_RS12735 ENOG4108JA2 transcriptioN-repair coupling factor BADSM9389_RS12740 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein BADSM9389_RS12745 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction BADSM9389_RS12750 ENOG4108IND Tetr family transcriptional regulator BADSM9389_RS12755 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction BADSM9389_RS12760 ENOG4108IND Tetr family transcriptional regulator BADSM9389_RS12780 ENOG4107MBR 17 kDa surface antigen BADSM9389_RS12785 ENOG4105CEP NADH dehydrogenase BADSM9389_RS12790 ENOG4105D0Y UPF0227 protein BADSM9389_RS12795 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) BADSM9389_RS12800 ENOG4108RUM thiamine kinase BADSM9389_RS12810 ENOG41090DQ Lipoprotein BADSM9389_RS12815 ENOG4105K59 histidine triad (HIT) protein BADSM9389_RS12820 ENOG4105CNM Receptor BADSM9389_RS12825 ENOG4105CI1 PTS System BADSM9389_RS12830 ENOG4105F8V Hydrolase, tatD family BADSM9389_RS12835 ENOG4107QRG dna polymerase iii BADSM9389_RS12845 ENOG4105HHA aminodeoxychorismate lyase BADSM9389_RS12850 ENOG4105YAZ 4-amino-4-deoxychorismate lyase BADSM9389_RS12855 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BADSM9389_RS12860 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) BADSM9389_RS12865 ENOG4105CHR reductase BADSM9389_RS12870 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BADSM9389_RS12880 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) BADSM9389_RS12885 ENOG4105VGS 50s ribosomal protein l32 BADSM9389_RS12890 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein BADSM9389_RS12895 ENOG4108UHJ MAF-like protein BADSM9389_RS12900 ENOG4105EI2 Pseudouridine synthase BADSM9389_RS12905 ENOG4107QQB Ribonuclease E BADSM9389_RS12910 ENOG4105DTJ flagellar hook-associated protein BADSM9389_RS12915 ENOG4105E1Q flagellar hook-associated protein BADSM9389_RS12920 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj BADSM9389_RS12925 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) BADSM9389_RS12935 ENOG4105CGA flagellar basal-body rod protein FlgG BADSM9389_RS12940 ENOG4108KPB Flagellar basal-body rod protein FlgF BADSM9389_RS12945 ENOG4105BZE flagellar hook protein, FlgE BADSM9389_RS12950 ENOG4105W00 Flagellar hook capping protein BADSM9389_RS12955 ENOG4108ZC9 flagellar basal-body rod protein flgc BADSM9389_RS12960 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) BADSM9389_RS12965 ENOG4105CKS Flagella basal body P-ring formation protein flgA BADSM9389_RS12970 ENOG4105M9M anti-sigma28 factor FlgM BADSM9389_RS12975 ENOG4105QVD Flagella synthesis protein FlgN BADSM9389_RS12985 ENOG4105CJR Integral membrane protein (MviN BADSM9389_RS12990 ENOG4105EP9 oxidoreductase BADSM9389_RS13000 ENOG4105D9U N-acetyltransferase BADSM9389_RS13010 ENOG4105E9S glutaredoxin 2 BADSM9389_RS13015 ENOG4105F3T (LipO)protein BADSM9389_RS13025 ENOG4105MEA DNA damage-inducible protein i BADSM9389_RS13030 ENOG4105PVA Biofilm formation regulatory protein BssS BADSM9389_RS13035 ENOG4105F76 Sarcosine oxidase BADSM9389_RS13040 ENOG4105C72 UPF0176 protein BADSM9389_RS13045 ENOG4105D1S lipid A biosynthesis BADSM9389_RS13050 ENOG4105C6X Major Facilitator BADSM9389_RS13055 ENOG4108W47 Acidic protein msyB BADSM9389_RS13060 ENOG4105NAC (LipO)protein BADSM9389_RS13065 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) BADSM9389_RS13075 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) BADSM9389_RS13080 ENOG4107RZC phospholipase d BADSM9389_RS13085 ENOG4108UVJ appr-1-p processing domain protein BADSM9389_RS13100 ENOG41064T2 transcriptional regulator, lysR family BADSM9389_RS13120 ENOG4105D5Q Arginine ornithine antiporter BADSM9389_RS13125 ENOG4105CXN decarboxylase BADSM9389_RS13130 ENOG4107YAK holo-(acyl carrier protein) synthase 2 BADSM9389_RS13135 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) BADSM9389_RS13140 ENOG4105C2D reductase BADSM9389_RS13175 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) BADSM9389_RS13220 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) BADSM9389_RS13230 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers BADSM9389_RS13235 ENOG41086KC Transcriptional regulator BADSM9389_RS13240 ENOG4108XDW curli assembly protein CsgE BADSM9389_RS13245 ENOG4108WYR Curli production assembly transport component, CsgF BADSM9389_RS13250 ENOG4105P8Q Curli production assembly transport component CsgG BADSM9389_RS13255 ENOG4108UQ5 membrane protein YcdZ BADSM9389_RS13260 ENOG4107XHZ cytoplasmic chaperone TorD family protein BADSM9389_RS13265 ENOG4107SSZ Phosphatase BADSM9389_RS13285 ENOG4105BZS acriflavin resistance protein BADSM9389_RS13290 ENOG4105C1P efflux transporter, rnd family, mfp subunit BADSM9389_RS13295 ENOG4105BZS acriflavin resistance protein BADSM9389_RS13300 ENOG4108XG4 DNA-binding transcriptional regulator BADSM9389_RS13305 ENOG410901P UPF0249 protein BADSM9389_RS13310 ENOG4105F8D glycoside hydrolase family 4 BADSM9389_RS13315 ENOG4105EZV Transcriptional regulator BADSM9389_RS13320 ENOG4105VCP PTS System BADSM9389_RS13325 ENOG4105CK1 PTS System BADSM9389_RS13330 ENOG4105VZJ PTS System BADSM9389_RS13335 ENOG4105D5M phosphate starvation-inducible protein BADSM9389_RS13340 ENOG4105DBE peroxidase BADSM9389_RS13345 ENOG410650H (LipO)protein BADSM9389_RS13350 ENOG4105EKT )-iron permease BADSM9389_RS13355 ENOG4105CK7 Sodium proline symporter BADSM9389_RS13360 ENOG4105C26 Dehydrogenase BADSM9389_RS13370 ENOG4108R86 Transcriptional regulator BADSM9389_RS13380 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) BADSM9389_RS13390 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) BADSM9389_RS13395 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) BADSM9389_RS13405 ENOG4105C2W permease BADSM9389_RS13415 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 BADSM9389_RS13420 ENOG4105CS1 NAD(P)H quinone oxidoreductase BADSM9389_RS13425 ENOG4105XH3 BADSM9389_RS13430 ENOG4105D6F Phosphatase BADSM9389_RS13435 ENOG4105EMU Dehydrogenase BADSM9389_RS13450 ENOG4107QSI ABC, transporter BADSM9389_RS13455 ENOG4108MN8 Membrane BADSM9389_RS13460 ENOG4108Z0T Part of a sulfur-relay system (By similarity) BADSM9389_RS13465 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 BADSM9389_RS13470 ENOG4105DR4 Methyltransferase BADSM9389_RS13475 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) BADSM9389_RS13480 ENOG4105K4P CoA-binding domain protein BADSM9389_RS13485 ENOG4108Q67 UPF0319 protein BADSM9389_RS13495 ENOG41088T4 Helicase IV BADSM9389_RS13500 ENOG410901E Membrane BADSM9389_RS13505 ENOG4105EM2 membrane BADSM9389_RS13510 ENOG4108RZ1 DNA transformation protein BADSM9389_RS13515 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) BADSM9389_RS13530 ENOG4105DAN ATP-dependent protease BADSM9389_RS13540 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) BADSM9389_RS13545 ENOG4108Q2G (LipO)protein BADSM9389_RS13550 ENOG4105DY2 Paraquat-inducible protein b BADSM9389_RS13555 ENOG4105F1S paraquat-inducible protein a BADSM9389_RS13560 ENOG4105C5H ABC transporter BADSM9389_RS13565 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) BADSM9389_RS13570 ENOG4105QVC MOSC domain-containing protein BADSM9389_RS13575 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) BADSM9389_RS13585 ENOG4108UZX fmn reductase BADSM9389_RS13590 ENOG4105GVF (ABC) transporter BADSM9389_RS13600 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component BADSM9389_RS13610 ENOG4105CD8 aminopeptidase N BADSM9389_RS13615 ENOG4107RH7 Nicotinate phosphoribosyltransferase BADSM9389_RS13620 ENOG4105C5S asparaginyl-tRNA synthetase BADSM9389_RS13625 ENOG4105ZIT Porin Gram-negative type BADSM9389_RS13630 ENOG4105CGF Aromatic amino acid aminotransferase BADSM9389_RS13635 ENOG4105C5X domain protein BADSM9389_RS13640 ENOG4105EAQ (twin-arginine translocation) pathway signal BADSM9389_RS13645 ENOG4105DIT ErfK YbiS YcfS YnhG family protein BADSM9389_RS13650 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) BADSM9389_RS13655 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) BADSM9389_RS13665 ENOG4106371 Methyltransferase BADSM9389_RS13670 ENOG4107S90 membrAne BADSM9389_RS13675 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups BADSM9389_RS13680 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) BADSM9389_RS13685 ENOG4105W49 UPF0434 protein BADSM9389_RS13690 ENOG4105T0Z Conserved Protein BADSM9389_RS13695 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) BADSM9389_RS13700 ENOG4105BZ1 (ABC) transporter BADSM9389_RS13705 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 BADSM9389_RS13710 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) BADSM9389_RS13715 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) BADSM9389_RS13720 ENOG4105CAT Cytidine monophosphate kinase BADSM9389_RS13730 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase BADSM9389_RS13735 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) BADSM9389_RS13740 ENOG4107VMU Membrane BADSM9389_RS13745 ENOG4105DDY UPF0142 protein ycaO BADSM9389_RS13750 ENOG4105TMB Formate nitrite transporter BADSM9389_RS13755 ENOG4105C6N Formate acetyltransferase BADSM9389_RS13760 ENOG4105F1A Pyruvate formate-lyase BADSM9389_RS13765 ENOG4108ISG Major Facilitator BADSM9389_RS13770 ENOG4107KGK dmso reductase anchor subunit BADSM9389_RS13775 ENOG4105QAX Iron-sulfur BADSM9389_RS13780 ENOG4107QY8 reductase BADSM9389_RS13785 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) BADSM9389_RS13790 ENOG4105D1H recombination factor protein RarA BADSM9389_RS13800 ENOG4105CNU cell division protein FtsK BADSM9389_RS13805 ENOG4105EW9 transcriptional regulator AsnC family BADSM9389_RS13810 ENOG4105C3M thioredoxin reductase BADSM9389_RS13815 ENOG4108JJ9 ABC, transporter BADSM9389_RS13820 ENOG4108JJ8 (ABC) transporter BADSM9389_RS13835 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BADSM9389_RS13840 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) BADSM9389_RS13845 ENOG4105VEQ Cold shock protein BADSM9389_RS13855 ENOG4105DJY efflux transporter, rnd family, mfp subunit BADSM9389_RS13860 ENOG4108MJ5 VirK protein BADSM9389_RS13865 ENOG4105CPB ATP-dependent endonuclease of the OLD family BADSM9389_RS13870 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BADSM9389_RS13875 ENOG4105DWU Membrane BADSM9389_RS13880 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) BADSM9389_RS13885 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) BADSM9389_RS13890 ENOG4105C7K acetolactate synthase BADSM9389_RS13895 ENOG4105C5W Aldolase BADSM9389_RS13900 ENOG4105CGD Nad-dependent epimerase dehydratase BADSM9389_RS13905 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase BADSM9389_RS13910 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase BADSM9389_RS13915 ENOG41064MM (LipO)protein BADSM9389_RS13920 ENOG4105E5Z arginine transporter ATP-binding subunit BADSM9389_RS13925 ENOG4106PMH Extracellular solute-binding protein family 3 BADSM9389_RS13930 ENOG4105GBT ABC transporter BADSM9389_RS13935 ENOG4105DMR ABC, transporter BADSM9389_RS13940 ENOG4106TNF Periplasmic binding protein BADSM9389_RS13950 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) BADSM9389_RS13955 ENOG4105RBQ inner membrane protein ybjO BADSM9389_RS13960 ENOG4105D38 putrescine abc transporter BADSM9389_RS13965 ENOG4105F38 ABC transporter, permease BADSM9389_RS13970 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) BADSM9389_RS13975 ENOG4107RUE extracellular solute-binding protein family 1 BADSM9389_RS13980 ENOG4108RMJ sensory transduction regulator BADSM9389_RS13985 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) BADSM9389_RS13990 ENOG4105CN8 Transcriptional regulator BADSM9389_RS13995 ENOG4105EAA nucleoside BADSM9389_RS14000 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) BADSM9389_RS14005 ENOG4108DBC nitroreductase BADSM9389_RS14010 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress BADSM9389_RS14015 ENOG41090BQ Glutaredoxin BADSM9389_RS14020 ENOG4105GWF inner membrane protein YbjM BADSM9389_RS14035 ENOG4108RFG Tetr family transcriptional regulator BADSM9389_RS14040 ENOG4106UW1 Major Facilitator superfamily BADSM9389_RS14045 ENOG4108HCJ Hydrolase BADSM9389_RS14050 ENOG4105F4P )-transporter BADSM9389_RS14055 ENOG4105KST dependent repressor BADSM9389_RS14065 ENOG4108I6E Sulfatase BADSM9389_RS14070 ENOG4108T1M outer membrane protein x BADSM9389_RS14080 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction BADSM9389_RS14085 ENOG4107R0W ABC transporter BADSM9389_RS14090 ENOG4105E5Q amino acid AbC transporter BADSM9389_RS14095 ENOG4105CDA abc transporter atp-binding protein BADSM9389_RS14100 ENOG4105D8X mechanosensitive ion channel BADSM9389_RS14105 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) BADSM9389_RS14110 ENOG4105EW6 flavin reductase domain protein, FMN-binding BADSM9389_RS14115 ENOG4105ZY9 UPF0379 protein ybiM BADSM9389_RS14120 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BADSM9389_RS14125 ENOG41069H7 transport system small permease component BADSM9389_RS14130 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BADSM9389_RS14135 ENOG4105CK1 PTS System BADSM9389_RS14145 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) BADSM9389_RS14160 ENOG4105VR4 UPF0379 protein ybiJ BADSM9389_RS14165 ENOG4108MTB glycosyl transferase family BADSM9389_RS14170 ENOG4105DVT helicase BADSM9389_RS14175 ENOG4105EZE Cupin 4 family protein BADSM9389_RS14180 ENOG4108XDN Transcriptional regulator BADSM9389_RS14185 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component BADSM9389_RS14190 ENOG4108IJ8 ABC transporter BADSM9389_RS14195 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component BADSM9389_RS14200 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system BADSM9389_RS14205 ENOG4105CS6 Rhs element vgr protein BADSM9389_RS14210 ENOG4105NVB glycoside hydrolase, family 19 BADSM9389_RS14230 ENOG4107QK4 glycoside hydrolase, family 3 domain protein BADSM9389_RS14235 ENOG4105CXG d-lactate dehydrogenase BADSM9389_RS14245 ENOG41061WM D-Alanyl-D-Alanine BADSM9389_RS14250 ENOG41069YE inner membrane protein yohC BADSM9389_RS14260 ENOG4105KHU inner membrane protein YohD BADSM9389_RS14265 ENOG4105H9W Short-chain dehydrogenase reductase Sdr BADSM9389_RS14285 ENOG4105CT4 transporter BADSM9389_RS14290 ENOG4108M0B Sucrose porin BADSM9389_RS14315 ENOG4105CS2 ec 3.2.1.21 BADSM9389_RS14330 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) BADSM9389_RS14335 ENOG4105C1J atp-dependent rna helicase BADSM9389_RS14340 ENOG4107MVR Transcriptional regulator BADSM9389_RS14345 ENOG4105D0S secretion protein (HlyD BADSM9389_RS14350 ENOG4105CJ1 ABC, transporter BADSM9389_RS14355 ENOG4107QWP ABC-2 type transporter BADSM9389_RS14360 ENOG4107QWP ABC-2 type transporter BADSM9389_RS14365 ENOG4105I9U inner membrane protein ybhQ BADSM9389_RS14370 ENOG4105X23 Endonuclease Exonuclease phosphatase BADSM9389_RS14375 ENOG4105DZQ phospholipase D Transphosphatidylase BADSM9389_RS14380 ENOG4107UXM Membrane BADSM9389_RS14385 ENOG4105HFZ Membrane BADSM9389_RS14390 ENOG4108ZAF Molybdopterin BADSM9389_RS14395 ENOG4105M00 molybdopterin converting factor, subunit 1 BADSM9389_RS14405 ENOG4108RIR Molybdenum cofactor biosynthesis protein BADSM9389_RS14415 ENOG4105CHW UPF0052 protein BADSM9389_RS14425 ENOG4108IV0 ABC, transporter BADSM9389_RS14440 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) BADSM9389_RS14445 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) BADSM9389_RS14455 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) BADSM9389_RS14470 ENOG4108V1U phospholipid-binding protein BADSM9389_RS14475 ENOG4105NBR Pectinesterase BADSM9389_RS14480 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) BADSM9389_RS14485 ENOG4108K4B hydrolase BADSM9389_RS14495 ENOG4105E0C molybdate abc transporter BADSM9389_RS14500 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein BADSM9389_RS14505 ENOG4105CJW magnesium transporter BADSM9389_RS14510 ENOG4105IBP Cyclic peptide transporter BADSM9389_RS14515 ENOG4105CF1 Alkylated DNA repair protein BADSM9389_RS14520 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) BADSM9389_RS14535 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC BADSM9389_RS14540 ENOG41068CG regulatoR BADSM9389_RS14545 ENOG4105BZU Histidine kinase BADSM9389_RS14555 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BADSM9389_RS14565 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BADSM9389_RS14570 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) BADSM9389_RS14575 ENOG4105XPH Ferredoxin BADSM9389_RS14580 ENOG4105CXY transporter BADSM9389_RS14585 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A BADSM9389_RS14595 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) BADSM9389_RS14605 ENOG4108UII YfaZ family BADSM9389_RS14610 ENOG4105DHQ Histidine kinase BADSM9389_RS14635 ENOG4105CEY Amp-dependent synthetase and ligase BADSM9389_RS14640 ENOG4105DNI Converts SHCHC to OSB (By similarity) BADSM9389_RS14645 ENOG4108IPT Naphthoate synthase BADSM9389_RS14660 ENOG4105E4F Isochorismate synthase BADSM9389_RS14665 ENOG4105TNS Conserved Protein BADSM9389_RS14670 ENOG4105XIQ Protein of unknown function (DUF2517) BADSM9389_RS14680 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BADSM9389_RS14685 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) BADSM9389_RS14690 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) BADSM9389_RS14695 ENOG4105C08 Histidine kinase BADSM9389_RS14700 ENOG4105EEX Two component transcriptional regulator (Winged helix family BADSM9389_RS14705 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 BADSM9389_RS14710 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) BADSM9389_RS14715 ENOG4105EV9 Alpha Beta Hydrolase BADSM9389_RS14720 ENOG4105NNH LexA regulated protein BADSM9389_RS14725 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) BADSM9389_RS14730 ENOG41090R7 Ferric uptake BADSM9389_RS14735 ENOG4105GX6 (LipO)protein BADSM9389_RS14750 ENOG4105CI1 PTS System BADSM9389_RS14760 ENOG4105CE4 GlcNAc 6-P deacetylase BADSM9389_RS14765 ENOG4105E2R ROK family BADSM9389_RS14770 ENOG4105D4U had-superfamily hydrolase, subfamily iia BADSM9389_RS14775 ENOG4105CAQ asparagine synthetase BADSM9389_RS14810 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family BADSM9389_RS14815 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) BADSM9389_RS14820 ENOG4105C9A Phoh family BADSM9389_RS14825 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) BADSM9389_RS14830 ENOG4108JU5 Magnesium and cobalt efflux protein BADSM9389_RS14835 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) BADSM9389_RS14840 ENOG4107RP9 extracellular solute-binding protein, family 3 BADSM9389_RS14845 ENOG4105EAD ABC transporter BADSM9389_RS14850 ENOG4105DRP amino acid AbC transporter BADSM9389_RS14855 ENOG4105CDA abc transporter atp-binding protein BADSM9389_RS14865 ENOG4107PAI alpha helical protein BADSM9389_RS14870 ENOG4105C8T Leucyl-tRNA synthetase BADSM9389_RS14880 ENOG4105DJF DNA polymerase III, delta' subunit BADSM9389_RS14890 ENOG4107QZB decarboxylase BADSM9389_RS14895 ENOG4108TGR phosphatase BADSM9389_RS14900 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) BADSM9389_RS14905 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) BADSM9389_RS14910 ENOG4105CJN penicillin-binding protein BADSM9389_RS14915 ENOG4105CNI cell division protein FtsW BADSM9389_RS14920 ENOG4105K6T rare lipoprotein A BADSM9389_RS14925 ENOG4105DZ1 carboxypeptidase BADSM9389_RS14930 ENOG4108Z43 UPF0250 protein BADSM9389_RS14940 ENOG41064T2 transcriptional regulator, lysR family BADSM9389_RS14960 ENOG4107Z6W Protein CrcB homolog BADSM9389_RS14970 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) BADSM9389_RS14975 ENOG4108IJF Heavy metal efflux pump, CzcA BADSM9389_RS14980 ENOG4105EP1 Efflux transporter rnd family, mfp subunit BADSM9389_RS14990 ENOG410624V efflux system protein BADSM9389_RS15000 ENOG4105CEE C4-dicarboxylate transporter BADSM9389_RS15005 ENOG4106YYS transcriptional regulatory protein BADSM9389_RS15010 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism BADSM9389_RS15015 ENOG4105DUA (citrate (pro-3S)-lyase ligase BADSM9389_RS15025 ENOG4105CI0 Citrate lyase BADSM9389_RS15030 ENOG4105CHY citrate lyase, alpha BADSM9389_RS15040 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase BADSM9389_RS15045 ENOG4107QPK )-transporter BADSM9389_RS15050 ENOG4105KTS ribonuclease BADSM9389_RS15070 ENOG4105C6Z Gluconate BADSM9389_RS15075 ENOG4105NXH GreA GreB family elongation factor BADSM9389_RS15080 ENOG4107P2S Transcriptional regulator BADSM9389_RS15085 ENOG4105CI1 PTS System BADSM9389_RS15090 ENOG4105S2T inner membrane protein YbcI BADSM9389_RS15095 ENOG4105WQ3 Rna-binding protein BADSM9389_RS15100 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) BADSM9389_RS15110 ENOG4107QJH Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) BADSM9389_RS15115 ENOG4105E5W Transporter BADSM9389_RS15130 ENOG4108T65 Fimbrial BADSM9389_RS15140 ENOG4105CW0 outer membrane usher protein BADSM9389_RS15145 ENOG4108VCD Chaperone BADSM9389_RS15150 ENOG4105US4 fimbrial-like protein yfcP BADSM9389_RS15155 ENOG4108PNB DNA-binding transcriptional regulator BADSM9389_RS15160 ENOG4108PNB DNA-binding transcriptional regulator BADSM9389_RS15170 ENOG4105C87 Aminotransferase class I and II BADSM9389_RS15175 ENOG4105DFD Na H antiporter BADSM9389_RS15180 ENOG41060NJ transcriptional regulator BADSM9389_RS15195 ENOG4108RTU Aldolase BADSM9389_RS15200 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 BADSM9389_RS15230 ENOG4105VZJ PTS System BADSM9389_RS15235 ENOG4105F8D glycoside hydrolase family 4 BADSM9389_RS15240 ENOG4105CK1 PTS System BADSM9389_RS15245 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain BADSM9389_RS15265 ENOG4105J12 Multidrug resistance protein mdtN BADSM9389_RS15275 ENOG4105IPI Membrane BADSM9389_RS15280 ENOG4105TDT uncharacterized protein yahO BADSM9389_RS15285 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) BADSM9389_RS15315 ENOG4105DZC cytosine deaminase BADSM9389_RS15320 ENOG4105C5B carbamate kinase BADSM9389_RS15330 ENOG4107REC cytoplasmic protein BADSM9389_RS15335 ENOG4107R1Q Membrane protein FdrA BADSM9389_RS15340 ENOG4105N16 Protein of unknown function (DUF2877) BADSM9389_RS15345 ENOG4107SNB ankyrin repeat protein YahD BADSM9389_RS15350 ENOG4108NUU Transcriptional regulator BADSM9389_RS15365 ENOG4105EJC lysr family transcriptional regulator BADSM9389_RS15375 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein BADSM9389_RS15380 ENOG4108MG3 formate dehydrogenase BADSM9389_RS15385 ENOG4105WQ6 Membrane BADSM9389_RS15390 ENOG4105CUY Mechanosensitive ion channel BADSM9389_RS15395 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) BADSM9389_RS15410 ENOG4105DQ4 alcohol dehydrogenase BADSM9389_RS15425 ENOG4105DAA L-lactate BADSM9389_RS15430 ENOG41073TP transcriptional regulator BADSM9389_RS15435 ENOG4105DMF Dehydrogenase BADSM9389_RS15440 ENOG4108Z9K Osmotically inducible protein BADSM9389_RS15450 ENOG4105EMN RNA polymerase sigma factor BADSM9389_RS15470 ENOG4105M71 acetolactate synthase 1 regulatory subunit BADSM9389_RS15475 ENOG4105C7K acetolactate synthase BADSM9389_RS15485 ENOG4105CKI cobalamin synthesis protein BADSM9389_RS15490 ENOG4105VCD cytoplasmic protein BADSM9389_RS15495 ENOG4105D22 carbon starvation protein BADSM9389_RS15500 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) BADSM9389_RS15505 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase BADSM9389_RS15510 ENOG4105WQI isochorismatase BADSM9389_RS15515 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase BADSM9389_RS15520 ENOG4105E4F Isochorismate synthase BADSM9389_RS15525 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein BADSM9389_RS15535 ENOG4105DQ5 transport system permease protein BADSM9389_RS15540 ENOG4105TVJ transport system, permease BADSM9389_RS15545 ENOG4105E0A ABC, transporter BADSM9389_RS15550 ENOG4105C0W non-ribosomal peptide synthetase BADSM9389_RS15555 ENOG41085A6 mbth domain-containing protein BADSM9389_RS15560 ENOG4105E93 esterase BADSM9389_RS15565 ENOG4107RNH Outer membrane receptor FepA BADSM9389_RS15570 ENOG4108TSE Transferase BADSM9389_RS15575 ENOG4105D82 Glutamate dehydrogenase BADSM9389_RS15585 ENOG4105D3R alkyl hydroperoxide reductase BADSM9389_RS15590 ENOG4108JU3 Alkyl hydroperoxide reductase BADSM9389_RS15600 ENOG4108PNB DNA-binding transcriptional regulator BADSM9389_RS15605 ENOG4105C8N cysteinyl-tRNA synthetase BADSM9389_RS15610 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) BADSM9389_RS15620 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) BADSM9389_RS15625 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit BADSM9389_RS15630 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) BADSM9389_RS15635 ENOG4105C5B carbamate kinase BADSM9389_RS15640 ENOG4105G5A Protein of unknown function (DUF2877) BADSM9389_RS15645 ENOG4107REC cytoplasmic protein BADSM9389_RS15650 ENOG4107R1Q Membrane protein FdrA BADSM9389_RS15655 ENOG4105DG4 malate L-lactate dehydrogenase BADSM9389_RS15660 ENOG4105CE7 Amidase, hydantoinase carbamoylase family BADSM9389_RS15665 ENOG4105S0E allantoin catabolism protein BADSM9389_RS15670 ENOG4105BZW Glycerate kinase BADSM9389_RS15675 ENOG4105DTE Xanthine uracil vitamin C permease BADSM9389_RS15680 ENOG4105CD3 dihydroorotase BADSM9389_RS15685 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BADSM9389_RS15690 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BADSM9389_RS15695 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) BADSM9389_RS15700 ENOG41060W2 glyoxylate carboligase BADSM9389_RS15720 ENOG4105CV6 ABC transporter, permease BADSM9389_RS15725 ENOG4108I0Y (ABC) transporter BADSM9389_RS15730 ENOG4108UJV acyl-CoA thioesterase i BADSM9389_RS15735 ENOG4105E1F short-chain dehydrogenase reductase BADSM9389_RS15740 ENOG4107QR8 Thioredoxin BADSM9389_RS15745 ENOG4107QX8 SPFH domain, Band 7 family protein BADSM9389_RS15750 ENOG4105G5H Membrane BADSM9389_RS15755 ENOG4105CS6 Rhs element vgr protein BADSM9389_RS15770 ENOG4108Z6Z Transcriptional regulator BADSM9389_RS15780 ENOG4105C59 p-type ATPase BADSM9389_RS15785 ENOG4105MBR gumn family BADSM9389_RS15790 ENOG4108Z66 YbaK ebsC protein BADSM9389_RS15795 ENOG4105F4I Transcriptional regulator BADSM9389_RS15800 ENOG4105CGH 5'-nucleotidase BADSM9389_RS15805 ENOG4105EU0 Major facilitator Superfamily BADSM9389_RS15810 ENOG4105CKD glutathione-regulated potassium-efflux system protein BADSM9389_RS15815 ENOG4107RE1 Inosine-guanosine kinase BADSM9389_RS15820 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) BADSM9389_RS15825 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) BADSM9389_RS15830 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) BADSM9389_RS15840 ENOG4105CHJ isochorismatase hydrolase BADSM9389_RS15845 ENOG4105EUB pirin domain protein BADSM9389_RS15850 ENOG4105CR8 Transcriptional regulator BADSM9389_RS15855 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) BADSM9389_RS15860 ENOG4107QMP dna polymerase iii subunits gamma and tau BADSM9389_RS15865 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) BADSM9389_RS15870 ENOG4105WD1 Membrane BADSM9389_RS15880 ENOG4106428 Protein of unknown function (DUF2496) BADSM9389_RS15885 ENOG4105EGS Mechanosensitive ion channel BADSM9389_RS15890 ENOG4107XI7 Tetr family transcriptional regulator BADSM9389_RS15895 ENOG4105C1P efflux transporter, rnd family, mfp subunit BADSM9389_RS15900 ENOG4105BZS acriflavin resistance protein BADSM9389_RS15905 ENOG4108UKR Biofilm formation regulator YbaJ BADSM9389_RS15915 ENOG4108UW5 maltose o-acetyltransferase BADSM9389_RS15920 ENOG4105GSJ Inner membrane protein ylaC BADSM9389_RS15925 ENOG4105YK5 50S ribosomal protein L36 BADSM9389_RS15935 ENOG4105D01 (LipO)protein BADSM9389_RS15945 ENOG4108UMI ABC transporter, permease BADSM9389_RS15950 ENOG4105C5Y PTS System BADSM9389_RS15955 ENOG4105CXK mandelate racemase muconate lactonizing BADSM9389_RS15965 ENOG41066DG (EAL) domain protein BADSM9389_RS15970 ENOG4108JUA Transcriptional regulator BADSM9389_RS15985 ENOG4105KCV RNA signal recognition particle 4.5S RNA BADSM9389_RS15995 ENOG4108VW9 Membrane BADSM9389_RS16010 ENOG4105EUZ Beta-lactamase domain protein BADSM9389_RS16020 ENOG41080UX Methyltransferase BADSM9389_RS16025 ENOG4108MNP Glycoprotein polysaccharide metabolism BADSM9389_RS16030 ENOG4105C29 acyl-CoA thioesterase BADSM9389_RS16035 ENOG4105BZU Histidine kinase BADSM9389_RS16040 ENOG4108YZA Nitrogen regulatory protein pii BADSM9389_RS16045 ENOG4105BZ1 (ABC) transporter BADSM9389_RS16050 ENOG4105BZ1 (ABC) transporter BADSM9389_RS16055 ENOG4108XM1 transcriptional regulator AsnC family BADSM9389_RS16065 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) BADSM9389_RS16070 ENOG4108NFA extracellular solute-binding protein BADSM9389_RS16075 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) BADSM9389_RS16080 ENOG4108TGP Thioesterase superfamily protein BADSM9389_RS16085 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein BADSM9389_RS16090 ENOG4105EIN peptidylprolyl cis-trans isomerase BADSM9389_RS16095 ENOG4105K70 DNA-binding protein BADSM9389_RS16100 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) BADSM9389_RS16115 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation BADSM9389_RS16120 ENOG4105M85 Bola protein BADSM9389_RS16125 ENOG4105IEY (LipO)protein BADSM9389_RS16130 ENOG4105EYM Major Facilitator superfamily BADSM9389_RS16135 ENOG4105E2S oxidase) subunit II BADSM9389_RS16140 ENOG4105BZ9 Cytochrome C oxidase, subunit I BADSM9389_RS16145 ENOG4105CCU oxidase (Subunit III) BADSM9389_RS16150 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) BADSM9389_RS16155 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) BADSM9389_RS16160 ENOG4107RDB Major Facilitator BADSM9389_RS16165 ENOG4108VPT UPF0234 protein BADSM9389_RS16170 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) BADSM9389_RS16175 ENOG4107S0N DJ-1 family BADSM9389_RS16185 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) BADSM9389_RS16190 ENOG4105CTB Polyprenyl synthetase BADSM9389_RS16195 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) BADSM9389_RS16200 ENOG4105CPC Aldo Keto reductase BADSM9389_RS16205 ENOG4108ZAI phosphatidylglycerophosphatase a BADSM9389_RS16210 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) BADSM9389_RS16220 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) BADSM9389_RS16225 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) BADSM9389_RS16235 ENOG4108KIC (LipO)protein BADSM9389_RS16240 ENOG4105DRB nucleoside-specific channel-forming protein BADSM9389_RS16245 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) BADSM9389_RS16255 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) BADSM9389_RS16265 ENOG4105VIE preprotein translocase, subunit YajC BADSM9389_RS16270 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) BADSM9389_RS16275 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) BADSM9389_RS16280 ENOG4108ZYK Acyl carrier protein phosphodiesterase BADSM9389_RS16285 ENOG4105D3R alkyl hydroperoxide reductase BADSM9389_RS16290 ENOG4105EFZ amidohydrolase BADSM9389_RS16300 ENOG4105CHJ isochorismatase hydrolase BADSM9389_RS16305 ENOG4107R28 alpha amylase, catalytic region BADSM9389_RS16310 ENOG4105T8A Uncharacterized protein YicS BADSM9389_RS16315 ENOG4105C85 amino acid BADSM9389_RS16320 ENOG4105CWM branched-chain amino acid transport system II carrier protein BADSM9389_RS16325 ENOG4105BZU Histidine kinase BADSM9389_RS16330 ENOG4105CK6 Two component transcriptional regulator (Winged helix family BADSM9389_RS16335 ENOG4107RH8 nuclease SbcCD subunit D BADSM9389_RS16340 ENOG4105EYH Exonuclease BADSM9389_RS16360 ENOG4105CS6 Rhs element vgr protein BADSM9389_RS16365 ENOG4105DKQ ROK family BADSM9389_RS16375 ENOG4105NBK UPF0345 protein BADSM9389_RS16380 ENOG4105HBA AroM protein BADSM9389_RS16385 ENOG4105SS3 BADSM9389_RS16390 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) BADSM9389_RS16395 ENOG4108UPT UPF0178 protein BADSM9389_RS16400 ENOG4105II7 pyrroline-5-carboxylate reductase BADSM9389_RS16405 ENOG4105BZU Histidine kinase BADSM9389_RS16410 ENOG4105VIF phosphate starvation-inducible protein BADSM9389_RS16415 ENOG4105RZQ Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway (By similarity) BADSM9389_RS16420 ENOG4105C6X Major Facilitator BADSM9389_RS16430 ENOG4105CPF Cell wall formation (By similarity) BADSM9389_RS16435 ENOG4105UNH Membrane BADSM9389_RS16440 ENOG4105FR5 inner membrane protein YaiY BADSM9389_RS16445 ENOG4107QS8 (LipO)protein BADSM9389_RS16450 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes BADSM9389_RS16455 ENOG4105CW7 secretion protein, HlyD family BADSM9389_RS16460 ENOG4105C0R drug resistance transporter emrb qaca subfamily BADSM9389_RS16465 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 BADSM9389_RS16470 ENOG4108RWI nicotinamidase BADSM9389_RS16475 ENOG4105D1S lipid A biosynthesis BADSM9389_RS16480 ENOG4107R6D beta-lactam binding protein AmpH BADSM9389_RS16485 ENOG4108PNB DNA-binding transcriptional regulator BADSM9389_RS16490 ENOG4108NSE outer membrane autotransporter barrel BADSM9389_RS16495 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) BADSM9389_RS16500 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) BADSM9389_RS16505 ENOG4105FCK Membrane BADSM9389_RS16520 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) BADSM9389_RS16525 ENOG4105CIN aminoacyl-histidine dipeptidase BADSM9389_RS16530 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) BADSM9389_RS16540 ENOG4105D26 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. The first step is catalyzed by NqrF, which accepts electrons from NADH and reduces ubiquinone-1 to ubisemiquinone by a one-electron transfer pathway (By similarity) BADSM9389_RS16545 ENOG4108IUB NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BADSM9389_RS16550 ENOG4105F5D NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BADSM9389_RS16555 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BADSM9389_RS16560 ENOG4108J5C NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) BADSM9389_RS16570 ENOG4105F7V ErfK ybiS ycfS ynhG family protein BADSM9389_RS16575 ENOG4105E7A Glutamine amidotransferase BADSM9389_RS16580 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) BADSM9389_RS16585 ENOG4107QPN acyl-Coa dehydrogenase BADSM9389_RS16590 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase BADSM9389_RS16595 ENOG4105VT2 5-hydroxyisourate hydrolase BADSM9389_RS16605 ENOG4105C5R Aminotransferase BADSM9389_RS16615 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) BADSM9389_RS16640 ENOG410633P Hydantoin racemase BADSM9389_RS16645 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease BADSM9389_RS16650 ENOG410600K aminopeptidase BADSM9389_RS16655 ENOG4108WC9 type VI secretion system effector, hcp1 family BADSM9389_RS16705 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit BADSM9389_RS16730 ENOG4105GMB type VI secretion system effector, hcp1 family BADSM9389_RS16755 ENOG4107RZZ dna polymerase iii epsilon subunit BADSM9389_RS16760 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) BADSM9389_RS16765 ENOG4105D1A Methyltransferase BADSM9389_RS16775 ENOG4105E9H Lytic Murein transglycosylase BADSM9389_RS16780 ENOG4105F2W methyltransferase BADSM9389_RS16785 ENOG4107NA1 Endonuclease Exonuclease phosphatase BADSM9389_RS16790 ENOG4105F27 Major Facilitator BADSM9389_RS16795 ENOG4105HEI LysR family (Transcriptional regulator BADSM9389_RS16800 ENOG4105CV8 reductase BADSM9389_RS16830 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase BADSM9389_RS16835 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) BADSM9389_RS16840 ENOG4108UMI ABC transporter, permease BADSM9389_RS16845 ENOG4105D01 (LipO)protein BADSM9389_RS16850 ENOG4108R8X outer membrane lipoprotein BADSM9389_RS16855 ENOG4108R96 Methyltransferase, YaeB family BADSM9389_RS16860 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) BADSM9389_RS16865 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion BADSM9389_RS16870 ENOG4108YZN class I peptide chain release factor BADSM9389_RS16875 ENOG4108VWS Yaeq family BADSM9389_RS16880 ENOG4105W1I UPF0253 protein BADSM9389_RS16885 ENOG4105M1T rho-binding antiterminator BADSM9389_RS16890 ENOG4105N7H Cytochrome BADSM9389_RS16895 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) BADSM9389_RS16900 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase BADSM9389_RS16905 ENOG4105CXN decarboxylase BADSM9389_RS16910 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) BADSM9389_RS16915 ENOG4105C0B DNA polymerase III (alpha subunit) BADSM9389_RS16925 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BADSM9389_RS16930 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BADSM9389_RS16935 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) BADSM9389_RS16940 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) BADSM9389_RS16945 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) BADSM9389_RS16950 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane BADSM9389_RS16955 ENOG4105DZP Membrane-associated zinc metalloprotease BADSM9389_RS16960 ENOG4105KNE Phosphatidate cytidylyltransferase BADSM9389_RS16970 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) BADSM9389_RS16975 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) BADSM9389_RS16990 ENOG4105CE9 30S ribosomal protein S2 BADSM9389_RS16995 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) BADSM9389_RS17000 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) BADSM9389_RS17010 ENOG4108T8E UPF0325 protein BADSM9389_RS17015 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR BADSM9389_RS17020 ENOG4105C0H protease BADSM9389_RS17025 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein BADSM9389_RS17040 ENOG4105EN6 Membrane BADSM9389_RS17045 ENOG4108YX9 iron--sulfur cluster insertion protein erpA BADSM9389_RS17050 ENOG4105CMQ Chloride channel BADSM9389_RS17060 ENOG4105S6R Iron-hydroxamate transporter permease subunit BADSM9389_RS17065 ENOG4105J76 Periplasmic binding protein BADSM9389_RS17070 ENOG4105E0A ABC, transporter BADSM9389_RS17075 ENOG4105E0K tonB-dependent siderophore receptor BADSM9389_RS17080 ENOG4105BZ4 penicillin-binding protein BADSM9389_RS17085 ENOG4105CQ7 ATP-dependent helicase BADSM9389_RS17090 ENOG4107XID 2'-5' rna ligase BADSM9389_RS17095 ENOG4105PW4 Sugar fermentation stimulation protein homolog BADSM9389_RS17100 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters BADSM9389_RS17105 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) BADSM9389_RS17110 ENOG4105DJ0 Poly(A) Polymerase BADSM9389_RS17115 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase BADSM9389_RS17120 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) BADSM9389_RS17130 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) BADSM9389_RS17135 ENOG4107BJW polysaccharide deacetylase BADSM9389_RS17140 ENOG4108YTN IIa component BADSM9389_RS17145 ENOG4105E3A (ABC) transporter BADSM9389_RS17150 ENOG4105DA5 (ABC) transporter BADSM9389_RS17155 ENOG41077A9 carbonic anhydrase BADSM9389_RS17160 ENOG4108UGV hypoxanthine phosphoribosyltransferase BADSM9389_RS17165 ENOG4105DZG Dehydrogenase BADSM9389_RS17170 ENOG4105E3B Multicopper oxidase BADSM9389_RS17175 ENOG4108ZRK uncharacterized protein yacC BADSM9389_RS17185 ENOG4108V1T peptidylprolyl cis-trans isomerase BADSM9389_RS17195 ENOG4107QIJ Aconitate hydratase 2 BADSM9389_RS17200 ENOG4108NST exported protein BADSM9389_RS17210 ENOG4107QN2 dihydrolipoyl dehydrogenase BADSM9389_RS17215 ENOG4107QSN dihydrolipoamide acetyltransferase BADSM9389_RS17220 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) BADSM9389_RS17235 ENOG4105CT4 transporter BADSM9389_RS17240 ENOG4105CUK Alpha-N-arabinofuranosidase (EC 3.2.1.55) BADSM9389_RS17245 ENOG4105CT4 transporter BADSM9389_RS17250 ENOG4105E4I Glycoside hydrolase family 28 BADSM9389_RS17255 ENOG4106A72 regulatory protein AmpE BADSM9389_RS17265 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase BADSM9389_RS17270 ENOG4108ZUW Major pilin subunit BADSM9389_RS17275 ENOG4107QHF type ii secretion system protein e BADSM9389_RS17280 ENOG4105D7Q type ii secretion system BADSM9389_RS17290 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) BADSM9389_RS17295 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) BADSM9389_RS17300 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) BADSM9389_RS17305 ENOG4105M6F mutator MutT protein BADSM9389_RS17315 ENOG4106Q9Y Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) BADSM9389_RS17330 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) BADSM9389_RS17335 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) BADSM9389_RS17340 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) BADSM9389_RS17350 ENOG4105DFU Cell wall formation (By similarity) BADSM9389_RS17360 ENOG4105CNI cell division protein FtsW BADSM9389_RS17370 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) BADSM9389_RS17375 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) BADSM9389_RS17380 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) BADSM9389_RS17385 ENOG4105CJN penicillin-binding protein BADSM9389_RS17390 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) BADSM9389_RS17400 ENOG4108V6E Cell division protein mraZ BADSM9389_RS17405 ENOG4107B7Y DNA-binding transcriptional regulator FruR BADSM9389_RS17410 ENOG4108ZP8 Acetolactate synthase small subunit BADSM9389_RS17415 ENOG4105C7K acetolactate synthase BADSM9389_RS17420 ENOG41064T2 transcriptional regulator, lysR family BADSM9389_RS17430 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) BADSM9389_RS17445 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) BADSM9389_RS17450 ENOG4105K33 Periplasmic Protein BADSM9389_RS17455 ENOG41090ED Protein with unknown function (DUF469) BADSM9389_RS17465 ENOG4105CEN a g-specific adenine glycosylase BADSM9389_RS17470 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) BADSM9389_RS17475 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division BADSM9389_RS17480 ENOG4105EAA nucleoside BADSM9389_RS17485 ENOG4105CXN decarboxylase BADSM9389_RS17500 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) BADSM9389_RS17510 ENOG4107TT5 NLP P60 protein BADSM9389_RS17530 ENOG4107EDW L-fucose operon activator BADSM9389_RS17545 ENOG4108ZZF transport protein (ExbD) BADSM9389_RS17550 ENOG4105CWK Biopolymer transport protein, ExbB BADSM9389_RS17555 ENOG4105C28 cystathionine BADSM9389_RS17560 ENOG4108K81 inner membrane protein YghB BADSM9389_RS17570 ENOG4105CF7 AraC family transcriptional regulator BADSM9389_RS17575 ENOG4108I6A alcohol dehydrogenase BADSM9389_RS17580 ENOG4105CV8 reductase BADSM9389_RS17585 ENOG4105CCT upf0313 protein BADSM9389_RS17590 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) BADSM9389_RS17595 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase BADSM9389_RS17600 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BADSM9389_RS17605 ENOG4105H4F exported protein BADSM9389_RS17610 ENOG4105XJC Two component transcriptional regulator (Winged helix family BADSM9389_RS17615 ENOG4105DHQ Histidine kinase BADSM9389_RS17620 ENOG4105NF4 modulator of drug activity BADSM9389_RS17625 ENOG4105VRH Antibiotic biosynthesis monooxygenase BADSM9389_RS17630 ENOG41064T2 transcriptional regulator, lysR family BADSM9389_RS17645 ENOG4105QEK Transcriptional regulator BADSM9389_RS17650 ENOG4108R66 Conserved Protein BADSM9389_RS17655 ENOG4107RJ1 sodium solute BADSM9389_RS17665 ENOG4105C9S Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity) BADSM9389_RS17670 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) BADSM9389_RS17675 ENOG4105IPS esterase BADSM9389_RS17680 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) BADSM9389_RS17685 ENOG4108SX3 cytoplasmic protein BADSM9389_RS17690 ENOG41087AY ADP-Ribose pyrophosphatase BADSM9389_RS17695 ENOG4105DFG type I secretion outer membrane protein BADSM9389_RS17700 ENOG4105F1G UPF0441 protein BADSM9389_RS17705 ENOG4106032 Glutathionylspermidine synthase BADSM9389_RS17710 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b BADSM9389_RS17720 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) BADSM9389_RS17725 ENOG4105W0Z cytoplasmic protein BADSM9389_RS17735 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) BADSM9389_RS17740 ENOG4105I7R Adenylate cyclase BADSM9389_RS17745 ENOG4106MWK domain protein BADSM9389_RS17750 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate BADSM9389_RS17755 ENOG4105EDR glucose galactose transporter BADSM9389_RS17760 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BADSM9389_RS17765 ENOG4105C8I hydrolase, family 38 BADSM9389_RS17770 ENOG4105DM4 PTS System BADSM9389_RS17775 ENOG4108YRF PTS System BADSM9389_RS17790 ENOG4107ZVW dihydroneopterin aldolase BADSM9389_RS17795 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) BADSM9389_RS17800 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) BADSM9389_RS17810 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) BADSM9389_RS17815 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) BADSM9389_RS17820 ENOG4108VCA G U mismatch-specific DNA glycosylase BADSM9389_RS17840 ENOG4105DFE Dna adenine methylase BADSM9389_RS17875 ENOG4105MEH BADSM9389_RS17890 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BADSM9389_RS17920 ENOG4105E2B Taurine dioxygenase BADSM9389_RS17925 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component BADSM9389_RS17930 ENOG4108ETV ABC transporter BADSM9389_RS17935 ENOG4106FTQ Taurine ABC transporter, periplasmic BADSM9389_RS18045 ENOG4105FA0 parb-like partition protein BADSM9389_RS18075 ENOG4105EE0 oxidoreductase BADSM9389_RS18080 ENOG4105DU1 integral membrane protein, terc BADSM9389_RS18085 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) BADSM9389_RS18090 ENOG4105P66 Membrane BADSM9389_RS18095 ENOG4105CTX dehydratase BADSM9389_RS18105 ENOG4105DPW Major facilitator superfamily MFS_1 BADSM9389_RS18110 ENOG4107YCY Transcriptional regulator BADSM9389_RS18115 ENOG4106W5V Membrane BADSM9389_RS18120 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) BADSM9389_RS18125 ENOG4105WAY exported protein BADSM9389_RS18130 ENOG4105NE1 Conserved Protein BADSM9389_RS18135 ENOG41090KG Inner membrane protein YqjE BADSM9389_RS18140 ENOG4105YJD BADSM9389_RS18145 ENOG4108VBZ doxx family BADSM9389_RS18150 ENOG4105CHF Glutathione S-transferase BADSM9389_RS18155 ENOG4105KAF membrAne BADSM9389_RS18160 ENOG4105CWB LysR family transcriptional Regulator BADSM9389_RS18165 ENOG4108CNN domain protein BADSM9389_RS18175 ENOG4105CEM UPF0597 protein BADSM9389_RS18180 ENOG4105C44 Serine transporter BADSM9389_RS18185 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) BADSM9389_RS18195 ENOG4105BZW Glycerate kinase BADSM9389_RS18200 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BADSM9389_RS18205 ENOG4105CNV Aldolase BADSM9389_RS18210 ENOG4105DJB Major Facilitator Superfamily BADSM9389_RS18215 ENOG4105CTX dehydratase BADSM9389_RS18220 ENOG4105G2Y Transcriptional regulator BADSM9389_RS18225 ENOG4105C0R drug resistance transporter emrb qaca subfamily BADSM9389_RS18230 ENOG4105E98 transcriptional regulator DeoR family BADSM9389_RS18235 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of BADSM9389_RS18240 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB BADSM9389_RS18250 ENOG4105F3R pts system mannose fructose sorbose family iid BADSM9389_RS18255 ENOG4108YTN IIa component BADSM9389_RS18260 ENOG4105CE4 GlcNAc 6-P deacetylase BADSM9389_RS18265 ENOG4105E70 isomerase BADSM9389_RS18270 ENOG4105D2N Aldolase BADSM9389_RS18285 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) BADSM9389_RS18295 ENOG41082RQ UPF0102 protein BADSM9389_RS18300 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) BADSM9389_RS18305 ENOG4105W4M Transport-associated protein BADSM9389_RS18310 ENOG4105EMD TRANSCRIPTIONal BADSM9389_RS18330 ENOG41069H0 dihydroorotase EC 3.5.2.3 BADSM9389_RS18365 ENOG4105CW0 outer membrane usher protein BADSM9389_RS18370 ENOG4108AF8 Chaperone BADSM9389_RS18390 ENOG4105CG6 trap dicarboxylate transporter dctm subunit BADSM9389_RS18400 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit BADSM9389_RS18405 ENOG4108K70 Transcriptional regulator BADSM9389_RS18410 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase BADSM9389_RS18415 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase BADSM9389_RS18420 ENOG4107TT2 Auxin Efflux Carrier BADSM9389_RS18470 ENOG4105CMS peptidase U62, modulator of DNA gyrase BADSM9389_RS18475 ENOG4105N42 UPF0307 protein BADSM9389_RS18480 ENOG4105DFU Cell wall formation (By similarity) BADSM9389_RS18490 ENOG4105C8Q Methyl-accepting chemotaxis BADSM9389_RS18495 ENOG41062B0 ABC transporter, permease BADSM9389_RS18500 ENOG4107R9N ABC transporter BADSM9389_RS18505 ENOG4105C2J ABC transporter BADSM9389_RS18510 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator BADSM9389_RS18515 ENOG4105F0N pyrophosphate phospho-hydrolase BADSM9389_RS18520 ENOG4108ZHD aig2 family BADSM9389_RS18525 ENOG4105MA0 exported protein BADSM9389_RS18530 ENOG4105CFU surface antigen BADSM9389_RS18555 ENOG4105C59 p-type ATPase BADSM9389_RS18560 ENOG4105C37 (CBS) domain BADSM9389_RS18565 ENOG41061GZ Protein of unknown function (DUF1107) BADSM9389_RS18570 ENOG4108UUE Transcriptional regulator BADSM9389_RS18575 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase BADSM9389_RS18580 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic BADSM9389_RS18585 ENOG4105KVH Transcriptional regulator BADSM9389_RS18590 ENOG4105ECR NmrA family BADSM9389_RS18600 ENOG4105DXC membrane BADSM9389_RS18605 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) BADSM9389_RS18615 ENOG4108V1T peptidylprolyl cis-trans isomerase BADSM9389_RS18620 ENOG4105FHY Opacity-associated protein A BADSM9389_RS18625 ENOG4105K9Q Binds to the 23S rRNA (By similarity) BADSM9389_RS18635 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) BADSM9389_RS18640 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) BADSM9389_RS18645 ENOG4105KIT UPF0379 protein yjfY BADSM9389_RS18650 ENOG4108MXZ Esterase BADSM9389_RS18655 ENOG4105WSB biofilm stress and motility protein A BADSM9389_RS18660 ENOG4105S17 UPF0379 protein yjfN BADSM9389_RS18665 ENOG4105CSU acyl-Coa dehydrogenase BADSM9389_RS18670 ENOG4105C2N RNA methyltransferase TrmH family group 3 BADSM9389_RS18675 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) BADSM9389_RS18685 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis BADSM9389_RS18695 ENOG4105EPW hflc protein BADSM9389_RS18700 ENOG4107QJR hflk protein BADSM9389_RS18705 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) BADSM9389_RS18710 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) BADSM9389_RS18715 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) BADSM9389_RS18725 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase BADSM9389_RS18730 ENOG4105K8N protein family UPF0079, ATPase BADSM9389_RS18735 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) BADSM9389_RS18740 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) BADSM9389_RS18760 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) BADSM9389_RS18770 ENOG4105DJ4 phosphatidylserine decarboxylase BADSM9389_RS18775 ENOG4105EGS Mechanosensitive ion channel BADSM9389_RS18790 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) BADSM9389_RS18795 ENOG4105E33 succinate dehydrogenase BADSM9389_RS18805 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) BADSM9389_RS18820 ENOG4105KPY Small multidrug resistance protein BADSM9389_RS18830 ENOG4106BSU Entericidin B BADSM9389_RS18835 ENOG4107PEH Entericidin EcnA/B family BADSM9389_RS18840 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) BADSM9389_RS18845 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein BADSM9389_RS18850 ENOG4108ZVF (LipO)protein BADSM9389_RS18855 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) BADSM9389_RS18860 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) BADSM9389_RS18865 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 BADSM9389_RS18870 ENOG4108IJ0 Aspartate ammonia-lyase BADSM9389_RS18875 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter BADSM9389_RS18880 ENOG4105VF7 tolerance protein BADSM9389_RS18890 ENOG4108SIC Transcriptional regulator BADSM9389_RS18900 ENOG4108HF7 Gcn5-related n-acetyltransferase BADSM9389_RS18940 ENOG41061MV Arylsulfatase BADSM9389_RS18945 ENOG4105C4X radical SAM domain protein BADSM9389_RS18950 ENOG4105C7R Atpase associated with various cellular activities aaa_3 BADSM9389_RS18990 ENOG4107V59 shikimate BADSM9389_RS18995 ENOG4105DJB Major Facilitator Superfamily BADSM9389_RS19005 ENOG4105CYM Glutathione S-transferase BADSM9389_RS19020 ENOG4108UII YfaZ family BADSM9389_RS19030 ENOG4108PNB DNA-binding transcriptional regulator BADSM9389_RS19035 ENOG4105KK7 inner membrane protein YiaW BADSM9389_RS19040 ENOG4105EFX secretion protein, HlyD family BADSM9389_RS19045 ENOG4105DWP Membrane BADSM9389_RS19050 ENOG4105BZU Histidine kinase BADSM9389_RS19060 ENOG4107RT3 EamA-like transporter family BADSM9389_RS19065 ENOG4105E5D amino acid BADSM9389_RS19070 ENOG4105CVK Glutamate decarboxylase BADSM9389_RS19080 ENOG4108V08 YfdX protein BADSM9389_RS19085 ENOG4105BZU Histidine kinase BADSM9389_RS19090 ENOG4108WQH regulatoR BADSM9389_RS19095 ENOG4105CK1 PTS System BADSM9389_RS19100 ENOG4105CS2 ec 3.2.1.21 BADSM9389_RS19110 ENOG4108YIV BADSM9389_RS19115 ENOG4108F5E vimentin BADSM9389_RS19120 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA BADSM9389_RS19125 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase BADSM9389_RS19135 ENOG4105D5T phosphonate abc transporter BADSM9389_RS19140 ENOG4105EHI Phosphonate ABC transporter, periplasmic BADSM9389_RS19150 ENOG4107RJJ Transcriptional regulator BADSM9389_RS19155 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG BADSM9389_RS19160 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH BADSM9389_RS19165 ENOG4105EKV Phosphonate metabolism protein BADSM9389_RS19170 ENOG4105FT8 Phosphonate metabolism BADSM9389_RS19175 ENOG4105ENV phosphonate C-P lyase system protein PhnK BADSM9389_RS19180 ENOG4105HRV phosphonate c-p lyase system protein phnl BADSM9389_RS19185 ENOG4105FD8 phosphonate metabolism protein PhnM BADSM9389_RS19190 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) BADSM9389_RS19195 ENOG410849A acetyltransferase, (GNAT) family BADSM9389_RS19200 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein BADSM9389_RS19205 ENOG4108UK5 Transposase BADSM9389_RS19210 ENOG4105E3R (LipO)protein BADSM9389_RS19215 ENOG4108Q9C Periplasmic Protein BADSM9389_RS19220 ENOG4108MDC (LipO)protein BADSM9389_RS19240 ENOG4105CFH Aspartokinase BADSM9389_RS19270 ENOG4105DZP Membrane-associated zinc metalloprotease BADSM9389_RS19295 ENOG4105CNN ABC, transporter BADSM9389_RS19300 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BADSM9389_RS19310 ENOG4105D2N Aldolase BADSM9389_RS19335 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) BADSM9389_RS19340 ENOG41062QD Membrane BADSM9389_RS19345 ENOG4107QN1 sodium solute BADSM9389_RS19350 ENOG4105DDC Oxidoreductase domain protein BADSM9389_RS19355 ENOG41067MG lrgb family BADSM9389_RS19365 ENOG4105CMU LysR family (Transcriptional regulator BADSM9389_RS19370 ENOG4105EEQ Na H antiporter BADSM9389_RS19375 ENOG4105C7N Xanthine uracil vitamin C permease BADSM9389_RS19380 ENOG4108K3A Glutathione S-transferase BADSM9389_RS19385 ENOG4108Z4X TRANSCRIPTIONal BADSM9389_RS19390 ENOG4108W3Q Transcriptional regulator BADSM9389_RS19395 ENOG4105PMV Membrane BADSM9389_RS19400 ENOG4105E89 ABC transporter BADSM9389_RS19405 ENOG4105CH2 amidohydrolase BADSM9389_RS19410 ENOG4108UUM single-stranded DNA-binding protein BADSM9389_RS19415 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) BADSM9389_RS19430 ENOG4105MSB protein, conserved in bacteria BADSM9389_RS19435 ENOG4105F0S class B acid phosphatase BADSM9389_RS19440 ENOG4105CGF Aromatic amino acid aminotransferase BADSM9389_RS19445 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) BADSM9389_RS19450 ENOG4105CDU Replicative dna helicase BADSM9389_RS19455 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein BADSM9389_RS19460 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) BADSM9389_RS19475 ENOG4105MYN Zinc uptake regulation protein BADSM9389_RS19480 ENOG4105VDW Csbd family BADSM9389_RS19485 ENOG4107R73 Mate efflux family protein BADSM9389_RS19490 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) BADSM9389_RS19495 ENOG41080IJ Diacylglycerol kinase BADSM9389_RS19510 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) BADSM9389_RS19515 ENOG4107W52 maltose operon periplasmic protein BADSM9389_RS19520 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) BADSM9389_RS19525 ENOG4108IJ9 (ABC) transporter BADSM9389_RS19530 ENOG4107FKK extracellular solute-binding protein family 1 BADSM9389_RS19535 ENOG4105D56 permease protein BADSM9389_RS19540 ENOG4105EG2 ABC transporter, permease BADSM9389_RS19550 ENOG4108ZR5 Conserved Protein BADSM9389_RS19555 ENOG4105FE9 pseudouridine synthase BADSM9389_RS19565 ENOG4105EAM Na Pi-cotransporter BADSM9389_RS19570 ENOG4105C3R Methionine synthase BADSM9389_RS19575 ENOG41069M3 Transcriptional regulator BADSM9389_RS19580 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) BADSM9389_RS19585 ENOG4108I9X Isocitrate lyase BADSM9389_RS19590 ENOG4107QP3 malate synthase g BADSM9389_RS19625 ENOG4105C12 Phosphoribosylglycinamide synthetase BADSM9389_RS19630 ENOG4108T8B Protein of unknown function (DUF1481) BADSM9389_RS19635 ENOG4105K70 DNA-binding protein BADSM9389_RS19640 ENOG4105R2J Conserved Protein BADSM9389_RS19645 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) BADSM9389_RS19660 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) BADSM9389_RS19665 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) BADSM9389_RS19675 ENOG4105D06 uba thif-type nad fad binding protein BADSM9389_RS19680 ENOG4105WHD thiamine biosynthesis protein ThiS BADSM9389_RS19685 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) BADSM9389_RS19690 ENOG4105D41 biosynthesis protein thiH BADSM9389_RS19695 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BADSM9389_RS19705 ENOG4105F8D glycoside hydrolase family 4 BADSM9389_RS19710 ENOG4105CK1 PTS System BADSM9389_RS19720 ENOG4105VCP PTS System BADSM9389_RS19725 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BADSM9389_RS19730 ENOG4107QIH DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) BADSM9389_RS19735 ENOG4105KBC Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity) BADSM9389_RS19740 ENOG4108VZM 50s ribosomal protein L10 BADSM9389_RS19745 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) BADSM9389_RS19755 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) BADSM9389_RS19760 ENOG4105PM1 preprotein translocase subunit SecE BADSM9389_RS19765 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) BADSM9389_RS19790 ENOG4105CS9 pantothenic acid kinase BADSM9389_RS19795 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase BADSM9389_RS19800 ENOG4105D4A Cell wall formation (By similarity) BADSM9389_RS19825 ENOG4108RR8 protoporphyrinogen oxidase BADSM9389_RS19830 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) BADSM9389_RS19835 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein BADSM9389_RS19840 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) BADSM9389_RS19850 ENOG4105CHU acetyl-coa acetyltransferase BADSM9389_RS19855 ENOG4107QK7 reductase BADSM9389_RS19860 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) BADSM9389_RS19865 ENOG4105MDZ Transcriptional activator rfaH BADSM9389_RS19870 ENOG4105D52 delta-aminolevulinic acid dehydratase BADSM9389_RS19875 ENOG4105F8V Hydrolase, tatD family BADSM9389_RS19880 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) BADSM9389_RS19885 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) BADSM9389_RS19890 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) BADSM9389_RS19895 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) BADSM9389_RS19900 ENOG4105JC1 sterol-binding domain protein BADSM9389_RS19905 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) BADSM9389_RS19910 ENOG4105CGY Dna recombination protein BADSM9389_RS19915 ENOG4107SXA Phosphorylase BADSM9389_RS19920 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) BADSM9389_RS19950 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) BADSM9389_RS19955 ENOG4105DZ2 Transcriptional regulator BADSM9389_RS19960 ENOG4105EMK carboxylate amino acid amine transporter BADSM9389_RS19965 ENOG4105DQF Hydrolase BADSM9389_RS19970 ENOG4108EUD Lysophospholipase BADSM9389_RS19975 ENOG410829K Lysine exporter protein (Lyse ygga) BADSM9389_RS19980 ENOG4105CCF Lysine exporter protein (Lyse ygga) BADSM9389_RS19985 ENOG4105C9U ATP-dependent DNA helicase RecQ BADSM9389_RS19990 ENOG4105HDD phospholipase BADSM9389_RS19995 ENOG4108VUY thioesterase Superfamily protein BADSM9389_RS20000 ENOG4105FR1 rard protein BADSM9389_RS20005 ENOG4107QUT magnesium and cobalt transport protein CorA BADSM9389_RS20010 ENOG4105C4R Atp-dependent dna helicase BADSM9389_RS20015 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant BADSM9389_RS20020 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) BADSM9389_RS20025 ENOG4105CT0 Protein of unknown function, DUF484 BADSM9389_RS20035 ENOG4105S7Z (LipO)protein BADSM9389_RS20045 ENOG4107T0K Adenylate cyclase BADSM9389_RS20050 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) BADSM9389_RS20055 ENOG41076E6 Uroporphyrinogen-III Synthase BADSM9389_RS20060 ENOG4105ECF c-methyltransferase BADSM9389_RS20065 ENOG410601J HemY protein BADSM9389_RS20095 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family BADSM9389_RS20100 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) BADSM9389_RS20110 ENOG4105EGZ biosynthesis protein BADSM9389_RS20115 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase BADSM9389_RS20120 ENOG4108WJ1 acetyltransferase BADSM9389_RS20125 ENOG4107QQG Dehydrogenase BADSM9389_RS20130 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase BADSM9389_RS20135 ENOG4105SFE lipopolysaccharide biosynthesis protein BADSM9389_RS20140 ENOG4105ESV Glycosyl transferase, family 4 BADSM9389_RS20145 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) BADSM9389_RS20155 ENOG4105C1J atp-dependent rna helicase BADSM9389_RS20160 ENOG4105C9X ppx gppa phosphatase BADSM9389_RS20165 ENOG4105C4R Atp-dependent dna helicase BADSM9389_RS20170 ENOG4105KQ5 peptidylprolyl cis-trans isomerase BADSM9389_RS20175 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase BADSM9389_RS20180 ENOG4105EMY transcriptional regulator BADSM9389_RS20185 ENOG4105C7B Threonine dehydratase BADSM9389_RS20195 ENOG4105CM2 brancheD-chain amino acid aminotransferase BADSM9389_RS20200 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit BADSM9389_RS20215 ENOG4105C0P Mg chelatase subunit ChlI BADSM9389_RS20225 ENOG4108WFC UPF0438 protein yifE BADSM9389_RS20270 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) BADSM9389_RS20280 ENOG4108Y73 Membrane BADSM9389_RS20285 ENOG4105EJ2 Transcriptional regulator BADSM9389_RS20290 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) BADSM9389_RS20295 ENOG4105C5Q Transcriptional regulator BADSM9389_RS20305 ENOG4105CDH Citrulline--aspartate ligase BADSM9389_RS20310 ENOG4105CAS nag kinase BADSM9389_RS20315 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase BADSM9389_RS20330 ENOG4105DIJ Phosphoethanolamine transferase BADSM9389_RS20335 ENOG4106R3P AraC family transcriptional regulator BADSM9389_RS20340 ENOG4108XCZ PTS System BADSM9389_RS20345 ENOG4108AHH pyruvate formate lyase II activase BADSM9389_RS20355 ENOG4108YRF PTS System BADSM9389_RS20360 ENOG4105DM4 PTS System BADSM9389_RS20365 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) BADSM9389_RS20370 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) BADSM9389_RS20375 ENOG4105DCT glycerol dehydrogenase BADSM9389_RS20380 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) BADSM9389_RS20385 ENOG4105SYT Methylenetetrahydrofolate reductase BADSM9389_RS20390 ENOG4105CFH Aspartokinase BADSM9389_RS20395 ENOG4105C28 cystathionine BADSM9389_RS20400 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) BADSM9389_RS20405 ENOG4105VFB Binds the 23S rRNA (By similarity) BADSM9389_RS20410 ENOG4105C25 Primosomal protein n' BADSM9389_RS20415 ENOG4105ETE Transcriptional regulator (LacI family BADSM9389_RS20420 ENOG41063M6 Cell Division Protein BADSM9389_RS20425 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) BADSM9389_RS20435 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase BADSM9389_RS20445 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) BADSM9389_RS20450 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) BADSM9389_RS20455 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) BADSM9389_RS20460 ENOG4105CBT Fructose-1,6-bisphosphatase BADSM9389_RS20465 ENOG4105DP0 ferredoxin-NADP reductase BADSM9389_RS20470 ENOG4108VTS Membrane BADSM9389_RS20475 ENOG4105EBK exported protein BADSM9389_RS20480 ENOG4105CP7 Triose-phosphate isomerase BADSM9389_RS20485 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) BADSM9389_RS20490 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein BADSM9389_RS20495 ENOG4105CTQ phosphohexokinase BADSM9389_RS20500 ENOG41076HS cation diffusion facilitator family transporter BADSM9389_RS20505 ENOG4105FMW periplasmic BADSM9389_RS20510 ENOG4105E3W Two component transcriptional regulator (Winged helix family BADSM9389_RS20515 ENOG4105E0F Histidine kinase BADSM9389_RS20520 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) BADSM9389_RS20525 ENOG4105D7W serine acetyltransferase BADSM9389_RS20530 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase BADSM9389_RS20535 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) BADSM9389_RS20540 ENOG4105VW4 glutaredoxin 3 BADSM9389_RS20545 ENOG4107YZP Rhodanese domain protein BADSM9389_RS20555 ENOG41063SB peptidase BADSM9389_RS20560 ENOG4105PXI polysaccharide deacetylase BADSM9389_RS20565 ENOG4105K64 Glycosyl transferase, family 2 BADSM9389_RS20575 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) BADSM9389_RS20580 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) BADSM9389_RS20585 ENOG4105XA0 heptosyltransferase ii BADSM9389_RS20590 ENOG4105D16 lipopolysaccharide heptosyltransferase i BADSM9389_RS20605 ENOG4105X1N Glycosyl transferase family 8 BADSM9389_RS20610 ENOG4108SEH involved in lipopolysaccharide biosynthesis BADSM9389_RS20615 ENOG4106AH0 Glycosyl Transferase BADSM9389_RS20620 ENOG4107XU6 Glycosyl transferase (Group 1 BADSM9389_RS20625 ENOG4107543 (lipo)polysaccharide BADSM9389_RS20630 ENOG4107RJ7 Glycosyl transferase (Group 1 BADSM9389_RS20635 ENOG4105DKP glycosyl transferase, family 9 BADSM9389_RS20640 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase BADSM9389_RS20645 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) BADSM9389_RS20650 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) BADSM9389_RS20660 ENOG4105KDC 50s ribosomal protein l28 BADSM9389_RS20670 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase BADSM9389_RS20675 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) BADSM9389_RS20680 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) BADSM9389_RS20690 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) BADSM9389_RS20695 ENOG4105DSJ YicC domain protein BADSM9389_RS20700 ENOG4105EN6 Membrane BADSM9389_RS20705 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) BADSM9389_RS20715 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) BADSM9389_RS20720 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) BADSM9389_RS20725 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase BADSM9389_RS20730 ENOG4105CB5 ATP-dependent DNA helicase recG BADSM9389_RS20735 ENOG4105D6U Sodium Glutamate Symporter BADSM9389_RS20740 ENOG4105C2W permease BADSM9389_RS20745 ENOG4105JV1 AsmA family BADSM9389_RS20750 ENOG4105SUU thioesterase domain BADSM9389_RS20765 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 BADSM9389_RS20770 ENOG4105E98 transcriptional regulator DeoR family BADSM9389_RS20775 ENOG4108MGF sugar kinase BADSM9389_RS20780 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase BADSM9389_RS20785 ENOG4105D2M Aldolase BADSM9389_RS20790 ENOG4107QKS N-acylglucosamine 2-epimerase BADSM9389_RS20795 ENOG4105CJQ hydrolase, family 31 BADSM9389_RS20800 ENOG4105CT4 transporter BADSM9389_RS20805 ENOG4105CT4 transporter BADSM9389_RS20810 ENOG4105CI3 gtp-binding protein typa BADSM9389_RS20815 ENOG4105C5F glutamine synthetase BADSM9389_RS20820 ENOG4105CUX Signal transduction histidine kinase BADSM9389_RS20825 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family BADSM9389_RS20830 ENOG4105D4P Coproporphyrinogen iii oxidase BADSM9389_RS20835 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) BADSM9389_RS20840 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) BADSM9389_RS20845 ENOG4105C2M dna polymerase I BADSM9389_RS20850 ENOG4106HNH Acyl-transferase BADSM9389_RS20855 ENOG4108Z33 Thiol disulfide Interchange Protein BADSM9389_RS20865 ENOG4105PC1 Conserved Protein BADSM9389_RS20870 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) BADSM9389_RS20875 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b BADSM9389_RS20905 ENOG4107EJG GntR family transcriptional regulator BADSM9389_RS20910 ENOG4105C0R drug resistance transporter emrb qaca subfamily BADSM9389_RS20915 ENOG4105ETE Transcriptional regulator (LacI family BADSM9389_RS20920 ENOG4108RVA ribokinase BADSM9389_RS20925 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator BADSM9389_RS20930 ENOG4105CNN ABC, transporter BADSM9389_RS20935 ENOG4105C2J ABC transporter BADSM9389_RS20945 ENOG4105DFH Transport of potassium into the cell (By similarity) BADSM9389_RS20955 ENOG4105EV2 VWA domain protein interacting with AAA ATPase BADSM9389_RS20960 ENOG4105CU9 asparagine synthetase A BADSM9389_RS20965 ENOG4108VVK transcriptional Regulator, AsnC BADSM9389_RS20970 ENOG4105QTB Flavodoxin BADSM9389_RS20975 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) BADSM9389_RS20980 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) BADSM9389_RS20985 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation BADSM9389_RS20990 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) BADSM9389_RS21005 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) BADSM9389_RS21020 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) BADSM9389_RS21025 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) BADSM9389_RS21040 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) BADSM9389_RS21045 ENOG4105DPW Major facilitator superfamily MFS_1 BADSM9389_RS21050 ENOG4105FE9 pseudouridine synthase BADSM9389_RS21055 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) BADSM9389_RS21060 ENOG4105C8U phosphate abc transporter BADSM9389_RS21065 ENOG4105E2Z phosphate ABC transporter (Permease BADSM9389_RS21070 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) BADSM9389_RS21080 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC BADSM9389_RS21090 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia BADSM9389_RS21100 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 BADSM9389_RS21105 ENOG4105C7N Xanthine uracil vitamin C permease BADSM9389_RS21110 ENOG4105HFT AraC family transcriptional regulator BADSM9389_RS21120 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) BADSM9389_RS21125 ENOG4108YYH Nadph-dependent fmn reductase BADSM9389_RS21130 ENOG4105E8Q phosphopantetheinyl transferase BADSM9389_RS21135 ENOG4105CY0 Metallo-Beta-Lactamase BADSM9389_RS21140 ENOG4105ETT transcriptional Regulator, LysR family BADSM9389_RS21150 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins BADSM9389_RS21155 ENOG4105VAS Could be involved in insertion of integral membrane proteins into the membrane (By similarity) BADSM9389_RS21165 ENOG4105VG0 50S ribosomal protein l34