locus-tag	class	description
FOC43_RS00010	COG3069	C4-dicarboxylate transmembrane transporter activity
FOC43_RS00030	COG0303	'Molybdopterin
FOC43_RS00035	COG0314	molybdopterin synthase activity
FOC43_RS00065	COG0243	molybdopterin cofactor binding
FOC43_RS00075	COG0437	4 iron, 4 sulfur cluster binding
FOC43_RS00085	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FOC43_RS00095	COG0425	Belongs to the sulfur carrier protein TusA family
FOC43_RS00110	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FOC43_RS00115	COG0425	Belongs to the sulfur carrier protein TusA family
FOC43_RS00150	COG0505	Belongs to the CarA family
FOC43_RS00165	COG0745	RESPONSE REGULATOR receiver
FOC43_RS00210	COG2887	Belongs to the helicase family. UvrD subfamily
FOC43_RS00215	COG1074	ATP-dependent DNA helicase activity
FOC43_RS00230	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FOC43_RS00235	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FOC43_RS00245	COG0546	phosphoglycolate phosphatase activity
FOC43_RS00280	COG1459	type II secretion system
FOC43_RS00285	COG0730	response to heat
FOC43_RS00310	COG3951	Flagellar rod assembly protein muramidase FlgJ
FOC43_RS00315	COG1706	bacterial-type flagellum-dependent cell motility
FOC43_RS00335	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FOC43_RS00355	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FOC43_RS00405	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FOC43_RS00405	COG0517	IMP dehydrogenase activity
FOC43_RS00415	COG1442	glycosyl transferase family 8
FOC43_RS00415	COG1216	Glycosyl transferase, family 2
FOC43_RS00420	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FOC43_RS00420	COG1215	transferase activity, transferring glycosyl groups
FOC43_RS00425	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
FOC43_RS00425	COG1215	transferase activity, transferring glycosyl groups
FOC43_RS00440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FOC43_RS00455	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
FOC43_RS00470	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FOC43_RS00490	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FOC43_RS00500	COG1218	3'(2'),5'-bisphosphate nucleotidase
FOC43_RS00505	COG0175	sulfate reduction
FOC43_RS00510	COG2895	sulfate adenylyltransferase (ATP) activity
FOC43_RS00515	COG0471	metal ion transport
FOC43_RS00515	COG3273	potassium ion transport
FOC43_RS00520	COG0529	Catalyzes the synthesis of activated sulfate
FOC43_RS00545	COG2124	cytochrome p450
FOC43_RS00555	COG0736	holo-[acyl-carrier-protein] synthase activity
FOC43_RS00560	COG1580	Controls the rotational direction of flagella during chemotaxis
FOC43_RS00575	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
FOC43_RS00580	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FOC43_RS00595	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FOC43_RS00600	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
FOC43_RS00605	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FOC43_RS00625	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FOC43_RS00635	COG3069	C4-dicarboxylate transmembrane transporter activity
FOC43_RS00640	COG0251	oxidation-reduction process
FOC43_RS00645	COG2964	Protein conserved in bacteria
FOC43_RS00655	COG0753	catalase activity
FOC43_RS00670	COG0716	FMN binding
FOC43_RS00690	COG3276	selenocysteine insertion sequence binding
FOC43_RS00705	COG2814	Major facilitator Superfamily
FOC43_RS00730	COG2853	Lipoprotein
FOC43_RS00740	COG2252	PERMEase
FOC43_RS00745	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FOC43_RS00755	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FOC43_RS00760	COG0114	fumarate hydratase activity
FOC43_RS00765	COG0628	permease
FOC43_RS00790	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FOC43_RS00800	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FOC43_RS00815	COG4607	ABC-type enterochelin transport system periplasmic component
FOC43_RS00820	COG4604	ABC transporter, ATP-binding protein
FOC43_RS00825	COG4605	iron ion homeostasis
FOC43_RS00830	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC43_RS00855	COG0575	Belongs to the CDS family
FOC43_RS00875	COG2165	general secretion pathway protein
FOC43_RS00895	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FOC43_RS00920	COG1028	Short-chain dehydrogenase reductase Sdr
FOC43_RS00925	COG1083	cytidylyl-transferase
FOC43_RS00935	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
FOC43_RS00940	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
FOC43_RS00945	COG2089	acid synthase
FOC43_RS00975	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FOC43_RS00980	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FOC43_RS00990	COG2089	acid synthase
FOC43_RS01005	COG0107	imidazoleglycerol-phosphate synthase activity
FOC43_RS01010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FOC43_RS01015	COG3980	spore coat polysaccharide biosynthesis protein
FOC43_RS01020	COG1083	cytidylyl-transferase
FOC43_RS01055	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FOC43_RS01065	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
FOC43_RS01085	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FOC43_RS01090	COG1086	Polysaccharide biosynthesis protein
FOC43_RS01100	COG0511	ligase activity, forming carbon-carbon bonds
FOC43_RS01105	COG0439	Biotin carboxylase
FOC43_RS01110	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FOC43_RS01115	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FOC43_RS01120	COG0281	malic enzyme
FOC43_RS01120	COG0280	phosphate acetyltransferase
FOC43_RS01125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FOC43_RS01130	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FOC43_RS01135	COG0569	domain protein
FOC43_RS01140	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FOC43_RS01160	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FOC43_RS01160	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FOC43_RS01170	COG0028	Belongs to the TPP enzyme family
FOC43_RS01175	COG0440	acetolactate synthase activity
FOC43_RS01190	COG0805	protein transport
FOC43_RS01200	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FOC43_RS01205	COG0494	nUDIX hydrolase
FOC43_RS01210	COG0527	aspartate kinase activity
FOC43_RS01225	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FOC43_RS01230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FOC43_RS01250	COG2890	protein-(glutamine-N5) methyltransferase activity
FOC43_RS01260	COG2860	membrane
FOC43_RS01270	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FOC43_RS01275	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FOC43_RS01280	COG0191	fructose-bisphosphate aldolase activity
FOC43_RS01300	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FOC43_RS01315	COG1942	4-Oxalocrotonate Tautomerase
FOC43_RS01330	COG1185	polyribonucleotide nucleotidyltransferase activity
FOC43_RS01355	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
FOC43_RS01360	COG2226	methyltransferase
FOC43_RS01385	COG0731	radical SAM domain protein
FOC43_RS01405	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FOC43_RS01430	COG0739	heme binding
FOC43_RS01435	COG0751	glycine-tRNA ligase activity
FOC43_RS01450	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FOC43_RS01450	COG0475	glutathione-regulated potassium exporter activity
FOC43_RS01455	COG0789	Transcriptional regulator
FOC43_RS01460	COG0484	heat shock protein binding
FOC43_RS01465	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FOC43_RS01470	COG0745	RESPONSE REGULATOR receiver
FOC43_RS01475	COG0642	Histidine kinase
FOC43_RS01515	COG2703	oxygen carrier activity
FOC43_RS01520	COG0745	RESPONSE REGULATOR receiver
FOC43_RS01525	COG0642	Histidine kinase
FOC43_RS01545	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FOC43_RS01560	COG1496	oxidoreductase activity
FOC43_RS01570	COG0739	heme binding
FOC43_RS01585	COG1295	ribonuclease BN
FOC43_RS01615	COG0552	protein localization to endoplasmic reticulum
FOC43_RS01620	COG0523	cobalamin synthesis protein
FOC43_RS01640	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FOC43_RS01655	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FOC43_RS01690	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FOC43_RS01705	COG1301	dicarboxylic acid transport
FOC43_RS01730	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FOC43_RS01735	COG0723	plastoquinol--plastocyanin reductase activity
FOC43_RS01740	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FOC43_RS01750	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FOC43_RS01755	COG0052	Belongs to the universal ribosomal protein uS2 family
FOC43_RS01765	COG1136	(ABC) transporter
FOC43_RS01780	COG0194	GDP metabolic process
FOC43_RS01785	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FOC43_RS01790	COG0018	arginyl-trna synthetase
FOC43_RS01805	COG0217	transcriptional regulatory protein
FOC43_RS01810	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FOC43_RS01815	COG0586	Pfam SNARE associated Golgi protein
FOC43_RS01820	COG0039	L-malate dehydrogenase activity
FOC43_RS01830	COG3610	response to peptide
FOC43_RS01850	COG2217	Heavy metal translocating P-type atpase
FOC43_RS01855	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FOC43_RS01860	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FOC43_RS01865	COG2217	Heavy metal translocating P-type atpase
FOC43_RS01880	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FOC43_RS01885	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
FOC43_RS01905	COG1216	Glycosyl transferase, family 2
FOC43_RS01950	COG1442	glycosyl transferase family 8
FOC43_RS01950	COG1216	Glycosyl transferase, family 2
FOC43_RS01975	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FOC43_RS01980	COG1132	(ABC) transporter
FOC43_RS01985	COG0438	transferase activity, transferring glycosyl groups
FOC43_RS01990	COG1215	transferase activity, transferring glycosyl groups
FOC43_RS01995	COG0438	transferase activity, transferring glycosyl groups
FOC43_RS02005	COG0438	transferase activity, transferring glycosyl groups
FOC43_RS02010	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FOC43_RS02015	COG0110	maltose O-acetyltransferase activity
FOC43_RS02020	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FOC43_RS02025	COG1086	Polysaccharide biosynthesis protein
FOC43_RS02030	COG0745	RESPONSE REGULATOR receiver
FOC43_RS02040	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FOC43_RS02050	COG1183	phosphatidylcholine synthase activity
FOC43_RS02055	COG2833	Protein of unknown function (DUF455)
FOC43_RS02060	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FOC43_RS02065	COG2095	MarC family integral membrane protein
FOC43_RS02070	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FOC43_RS02075	COG0542	response to heat
FOC43_RS02085	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
FOC43_RS02090	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FOC43_RS02130	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FOC43_RS02135	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FOC43_RS02150	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FOC43_RS02155	COG1862	Preprotein translocase
FOC43_RS02160	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FOC43_RS02165	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FOC43_RS02190	COG0739	heme binding
FOC43_RS02200	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FOC43_RS02220	COG0352	thiamine-phosphate diphosphorylase activity
FOC43_RS02245	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FOC43_RS02250	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
FOC43_RS02260	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FOC43_RS02265	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FOC43_RS02270	COG0629	single-stranded DNA binding
FOC43_RS02275	COG0360	Binds together with S18 to 16S ribosomal RNA
FOC43_RS02280	COG2271	Major facilitator Superfamily
FOC43_RS02295	COG0750	zinc metalloprotease
FOC43_RS02300	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
FOC43_RS02305	COG0778	Nitroreductase
FOC43_RS02310	COG0778	Nitroreductase
FOC43_RS02320	COG1058	Belongs to the CinA family
FOC43_RS02320	COG1546	Belongs to the CinA family
FOC43_RS02325	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
FOC43_RS02330	COG0154	amidase activity
FOC43_RS02335	COG0516	GMP reductase activity
FOC43_RS02335	COG0517	IMP dehydrogenase activity
FOC43_RS02340	COG1722	exodeoxyribonuclease VII activity
FOC43_RS02380	COG1193	negative regulation of DNA recombination
FOC43_RS02390	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
FOC43_RS02400	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FOC43_RS02445	COG0352	thiamine-phosphate diphosphorylase activity
FOC43_RS02470	COG0772	Belongs to the SEDS family
FOC43_RS02475	COG0439	Biotin carboxylase
FOC43_RS02510	COG0481	GTPase activity
FOC43_RS02525	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FOC43_RS02540	COG2204	response regulator
FOC43_RS02545	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FOC43_RS02555	COG4773	Receptor
FOC43_RS02595	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FOC43_RS02595	COG1333	cytochrome c biogenesis protein
FOC43_RS02630	COG0343	queuine tRNA-ribosyltransferase activity
FOC43_RS02650	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FOC43_RS02655	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FOC43_RS02675	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FOC43_RS02680	COG0583	DNA-binding transcription factor activity
FOC43_RS02685	COG2855	membrane
FOC43_RS02695	COG0357	Ribosomal RNA small subunit methyltransferase G
FOC43_RS02700	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FOC43_RS02705	COG0113	porphobilinogen synthase activity
FOC43_RS02710	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FOC43_RS02720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FOC43_RS02725	COG2181	nitrate reductase activity
FOC43_RS02725	COG0247	lactate metabolic process
FOC43_RS02740	COG3022	response to hydroperoxide
FOC43_RS02750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FOC43_RS02755	COG0477	Major facilitator Superfamily
FOC43_RS02760	COG2195	Cleaves the N-terminal amino acid of tripeptides
FOC43_RS02765	COG1525	nuclease
FOC43_RS02805	COG0733	neurotransmitter:sodium symporter activity
FOC43_RS02810	COG0733	neurotransmitter:sodium symporter activity
FOC43_RS02830	COG0012	GTP binding
FOC43_RS02835	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FOC43_RS02845	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FOC43_RS02860	COG2201	protein-glutamate methylesterase activity
FOC43_RS02865	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FOC43_RS02870	COG1126	abc transporter atp-binding protein
FOC43_RS02875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FOC43_RS02880	COG0765	amino acid transport
FOC43_RS02885	COG0765	amino acid transport
FOC43_RS02890	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FOC43_RS02895	COG1966	Carbon starvation protein
FOC43_RS02900	COG2879	small protein
FOC43_RS02915	COG0776	regulation of translation
FOC43_RS02920	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FOC43_RS02925	COG1999	signal sequence binding
FOC43_RS02950	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FOC43_RS02955	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FOC43_RS02960	COG1115	amino acid carrier protein
FOC43_RS02965	COG1126	abc transporter atp-binding protein
FOC43_RS02970	COG0765	amino acid transport
FOC43_RS02980	COG0537	adenosine 5'-monophosphoramidase activity
FOC43_RS02985	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FOC43_RS03005	COG0539	negative regulation of cytoplasmic translation
FOC43_RS03005	COG1185	polyribonucleotide nucleotidyltransferase activity
FOC43_RS03015	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FOC43_RS03020	COG0745	RESPONSE REGULATOR receiver
FOC43_RS03025	COG2205	protein histidine kinase activity
FOC43_RS03025	COG2202	Pas domain
FOC43_RS03030	COG0488	(ABC) transporter
FOC43_RS03040	COG0303	'Molybdopterin
FOC43_RS03055	COG0512	Glutamine amidotransferase of anthranilate synthase
FOC43_RS03055	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FOC43_RS03065	COG0582	viral genome integration into host DNA
FOC43_RS03090	COG2404	hydrolase activity, acting on ester bonds
FOC43_RS03095	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FOC43_RS03100	COG1959	2 iron, 2 sulfur cluster binding
FOC43_RS03105	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FOC43_RS03110	COG1196	nuclear chromosome segregation
FOC43_RS03110	COG1674	ftsk spoiiie
FOC43_RS03115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FOC43_RS03130	COG0642	Histidine kinase
FOC43_RS03140	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
FOC43_RS03180	COG0765	amino acid transport
FOC43_RS03190	COG4452	Inner membrane protein CreD
FOC43_RS03205	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FOC43_RS03215	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FOC43_RS03230	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FOC43_RS03235	COG2957	Belongs to the agmatine deiminase family
FOC43_RS03245	COG0840	transmembrane signaling receptor activity
FOC43_RS03250	COG0138	bifunctional purine biosynthesis protein purh
FOC43_RS03255	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FOC43_RS03260	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FOC43_RS03275	COG0706	membrane insertase activity
FOC43_RS03280	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FOC43_RS03290	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FOC43_RS03305	COG0824	Thioesterase
FOC43_RS03360	COG0803	Belongs to the bacterial solute-binding protein 9 family
FOC43_RS03370	COG0681	Belongs to the peptidase S26 family
FOC43_RS03385	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FOC43_RS03415	COG0688	phosphatidylethanolamine metabolic process
FOC43_RS03420	COG1408	metallophosphoesterase
FOC43_RS03425	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FOC43_RS03450	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FOC43_RS03460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC43_RS03460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FOC43_RS03470	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FOC43_RS03475	COG1049	propionate catabolic process, 2-methylcitrate cycle
FOC43_RS03485	COG4221	oxidoreductase activity
FOC43_RS03490	COG1757	Na H antiporter
FOC43_RS03510	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FOC43_RS03515	COG0101	tRNA pseudouridine synthase activity
FOC43_RS03545	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FOC43_RS03550	COG1338	Plays a role in the flagellum-specific transport system
FOC43_RS03610	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FOC43_RS03615	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FOC43_RS03620	COG1663	tetraacyldisaccharide 4'-kinase activity
FOC43_RS03625	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FOC43_RS03640	COG1028	Short-chain dehydrogenase reductase Sdr
FOC43_RS03650	COG0612	Peptidase, M16
FOC43_RS03655	COG0167	dihydroorotate dehydrogenase activity
FOC43_RS03660	COG1132	(ABC) transporter
FOC43_RS03665	COG0215	cysteine-tRNA ligase activity
FOC43_RS03670	COG0728	peptidoglycan biosynthetic process
FOC43_RS03680	COG0632	four-way junction helicase activity
FOC43_RS03685	COG1181	Belongs to the D-alanine--D-alanine ligase family
FOC43_RS03705	COG0204	Acyl-transferase
FOC43_RS03705	COG0318	PFAM AMP-dependent synthetase and ligase
FOC43_RS03715	COG0788	formyltetrahydrofolate deformylase activity
FOC43_RS03720	COG0617	tRNA 3'-terminal CCA addition
FOC43_RS03745	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
FOC43_RS03760	COG3043	anaerobic respiration
FOC43_RS03765	COG0348	domain, Protein
FOC43_RS03770	COG0437	4 iron, 4 sulfur cluster binding
FOC43_RS03780	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FOC43_RS03790	COG0210	DNA helicase
FOC43_RS03805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FOC43_RS03810	COG2011	ABC-type metal ion transport system permease component
FOC43_RS03815	COG1464	Belongs to the NlpA lipoprotein family
FOC43_RS03820	COG1464	Belongs to the NlpA lipoprotein family
FOC43_RS03825	COG1464	Belongs to the NlpA lipoprotein family
FOC43_RS03835	COG0163	prenyltransferase activity
FOC43_RS03840	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FOC43_RS03845	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FOC43_RS03855	COG1166	arginine decarboxylase activity
FOC43_RS03860	COG1045	serine acetyltransferase
FOC43_RS03865	COG0436	Aminotransferase
FOC43_RS03885	COG0443	Heat shock 70 kDa protein
FOC43_RS03890	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
FOC43_RS03895	COG1420	regulation of RNA biosynthetic process
FOC43_RS03900	COG4771	TonB-dependent receptor
FOC43_RS03910	COG0675	Transposase, IS605 OrfB family
FOC43_RS03960	COG3842	ATPase activity
FOC43_RS03990	COG0598	Magnesium transport protein CorA
FOC43_RS03995	COG0521	Mo-molybdopterin cofactor biosynthetic process
FOC43_RS04005	COG0501	Belongs to the peptidase M48B family
FOC43_RS04010	COG2890	protein-(glutamine-N5) methyltransferase activity
FOC43_RS04025	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FOC43_RS04030	COG0587	DNA-directed DNA polymerase activity
FOC43_RS04035	COG1393	Belongs to the ArsC family
FOC43_RS04040	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FOC43_RS04045	COG2351	hydroxyisourate hydrolase activity
FOC43_RS04050	COG0335	large ribosomal subunit rRNA binding
FOC43_RS04055	COG0336	Belongs to the RNA methyltransferase TrmD family
FOC43_RS04060	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FOC43_RS04065	COG1837	Belongs to the UPF0109 family
FOC43_RS04070	COG0228	four-way junction DNA binding
FOC43_RS04075	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FOC43_RS04080	COG0564	pseudouridine synthase activity
FOC43_RS04085	COG1519	Transferase
FOC43_RS04095	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FOC43_RS04110	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FOC43_RS04115	COG0826	peptidase U32
FOC43_RS04125	COG0174	glutamine synthetase
FOC43_RS04130	COG4786	Flagellar basal body rod
FOC43_RS04135	COG4786	Flagellar basal body rod
FOC43_RS04140	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FOC43_RS04145	COG0849	cell division
FOC43_RS04150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FOC43_RS04155	COG0275	rRNA processing
FOC43_RS04170	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
FOC43_RS04175	COG0280	phosphate acetyltransferase
FOC43_RS04185	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FOC43_RS04190	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FOC43_RS04215	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FOC43_RS04220	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FOC43_RS04225	COG1137	ATPase activity
FOC43_RS04230	COG0802	atpase or kinase
FOC43_RS04235	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FOC43_RS04240	COG0137	argininosuccinate synthase activity
FOC43_RS04255	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FOC43_RS04260	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FOC43_RS04310	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FOC43_RS04315	COG0741	lytic transglycosylase activity
FOC43_RS04315	COG1388	LysM domain
FOC43_RS04320	COG0084	hydrolase, TatD family'
FOC43_RS04330	COG0497	DNA recombination
FOC43_RS04345	COG0563	adenylate kinase activity
FOC43_RS04350	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FOC43_RS04355	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FOC43_RS04370	COG0758	DNA mediated transformation
FOC43_RS04380	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FOC43_RS04385	COG0557	exoribonuclease II activity
FOC43_RS04390	COG1466	dna polymerase III delta subunit
FOC43_RS04395	COG0375	protein maturation
FOC43_RS04400	COG0309	Hydrogenase expression formation protein (HypE)
FOC43_RS04405	COG0409	Hydrogenase expression formation protein
FOC43_RS04410	COG0298	carbon dioxide binding
FOC43_RS04420	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FOC43_RS04435	COG0534	Mate efflux family protein
FOC43_RS04450	COG0581	inorganic phosphate transmembrane transporter activity
FOC43_RS04455	COG0573	inorganic phosphate transmembrane transporter activity
FOC43_RS04460	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FOC43_RS04465	COG1528	Iron-storage protein
FOC43_RS04470	COG1696	Membrane protein involved in D-alanine export
FOC43_RS04485	COG1538	Outer membrane efflux protein
FOC43_RS04490	COG0577	efflux transmembrane transporter activity
FOC43_RS04490	COG1136	(ABC) transporter
FOC43_RS04495	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FOC43_RS04500	COG1473	amidohydrolase
FOC43_RS04515	COG2258	MOSC domain
FOC43_RS04520	COG0733	neurotransmitter:sodium symporter activity
FOC43_RS04525	COG4773	Receptor
FOC43_RS04535	COG0745	RESPONSE REGULATOR receiver
FOC43_RS04540	COG0642	Histidine kinase
FOC43_RS04550	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
FOC43_RS04555	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
FOC43_RS04560	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
FOC43_RS04565	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
FOC43_RS04585	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FOC43_RS04590	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FOC43_RS04595	COG1758	RNA polymerase activity
FOC43_RS04600	COG0528	UMP kinase activity
FOC43_RS04615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FOC43_RS04620	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FOC43_RS04630	COG0564	pseudouridine synthase activity
FOC43_RS04635	COG0772	Belongs to the SEDS family
FOC43_RS04655	COG0305	Participates in initiation and elongation during chromosome replication
FOC43_RS04670	COG0492	ferredoxin-NADP+ reductase activity
FOC43_RS04675	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FOC43_RS04685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FOC43_RS04705	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FOC43_RS04715	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FOC43_RS04720	COG0181	hydroxymethylbilane synthase activity
FOC43_RS04730	COG0442	prolyl-tRNA aminoacylation
FOC43_RS04735	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FOC43_RS04740	COG0142	geranyltranstransferase activity
FOC43_RS04760	COG1013	pyruvate-flavodoxin oxidoreductase activity
FOC43_RS04765	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FOC43_RS04765	COG0674	pyruvate-flavodoxin oxidoreductase activity
FOC43_RS04775	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FOC43_RS04780	COG0045	succinate-CoA ligase (ADP-forming) activity
FOC43_RS04785	COG0039	L-malate dehydrogenase activity
FOC43_RS04805	COG1815	bacterial-type flagellum-dependent cell motility
FOC43_RS04810	COG1558	bacterial-type flagellum-dependent cell motility
FOC43_RS04815	COG1677	Flagellar hook-basal body complex protein FliE
FOC43_RS04820	COG0768	penicillin binding
FOC43_RS04840	COG0326	Molecular chaperone. Has ATPase activity
FOC43_RS04845	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
FOC43_RS04850	COG0204	Acyl-transferase
FOC43_RS04860	COG0047	phosphoribosylformylglycinamidine synthase activity
FOC43_RS04865	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FOC43_RS04870	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FOC43_RS04875	COG0793	Belongs to the peptidase S41A family
FOC43_RS04885	COG0542	response to heat
FOC43_RS04900	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FOC43_RS04910	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
FOC43_RS04925	COG0004	ammonium transporteR
FOC43_RS04930	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
FOC43_RS04975	COG0049	tRNA binding
FOC43_RS04980	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FOC43_RS04985	COG1012	belongs to the aldehyde dehydrogenase family
FOC43_RS04990	COG3254	rhamnose metabolic process
FOC43_RS05000	COG0738	Major facilitator superfamily
FOC43_RS05005	COG1028	Short-chain dehydrogenase reductase Sdr
FOC43_RS05010	COG2271	Major facilitator Superfamily
FOC43_RS05015	COG2721	sulfolactate sulfo-lyase activity
FOC43_RS05025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
FOC43_RS05040	COG0085	RNA polymerase activity
FOC43_RS05045	COG0222	ribosome binding
FOC43_RS05050	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
FOC43_RS05055	COG0081	regulation of translation
FOC43_RS05060	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FOC43_RS05065	COG0250	Participates in transcription elongation, termination and antitermination
FOC43_RS05080	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FOC43_RS05085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FOC43_RS05110	COG1126	abc transporter atp-binding protein
FOC43_RS05115	COG0765	amino acid transport
FOC43_RS05130	COG2346	COG2346, Truncated hemoglobins
FOC43_RS05135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FOC43_RS05140	COG0612	Peptidase, M16
FOC43_RS05145	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FOC43_RS05155	COG0195	Participates in both transcription termination and antitermination
FOC43_RS05170	COG2121	Domain of unknown function (DUF374)
FOC43_RS05190	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
FOC43_RS05195	COG2176	DNA-directed DNA polymerase activity
FOC43_RS05200	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FOC43_RS05205	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FOC43_RS05225	COG4771	TonB-dependent receptor
FOC43_RS05230	COG2301	Belongs to the HpcH HpaI aldolase family
FOC43_RS05240	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
FOC43_RS05255	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FOC43_RS05260	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FOC43_RS05265	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FOC43_RS05275	COG1028	Short-chain dehydrogenase reductase Sdr
FOC43_RS05285	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FOC43_RS05290	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FOC43_RS05335	COG1739	Uncharacterized protein family UPF0029
FOC43_RS05350	COG0488	(ABC) transporter
FOC43_RS05405	COG1132	(ABC) transporter
FOC43_RS05410	COG1160	GTP binding
FOC43_RS05415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FOC43_RS05420	COG1053	succinate dehydrogenase
FOC43_RS05440	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FOC43_RS05495	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FOC43_RS05500	COG0579	oxidoreductase
FOC43_RS05505	COG0469	pyruvate kinase activity
FOC43_RS05530	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FOC43_RS05535	COG1160	GTP binding
FOC43_RS05540	COG2076	Multidrug Resistance protein
FOC43_RS05550	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FOC43_RS05555	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FOC43_RS05570	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FOC43_RS05580	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FOC43_RS05600	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FOC43_RS05605	COG0754	glutathionylspermidine amidase activity
FOC43_RS05615	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FOC43_RS05630	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FOC43_RS05640	COG1538	Outer membrane efflux protein
FOC43_RS05650	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FOC43_RS05655	COG1981	membrane
FOC43_RS05660	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FOC43_RS05685	COG0745	RESPONSE REGULATOR receiver
FOC43_RS05690	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FOC43_RS05705	COG1776	CheC inhibitor of MCP methylation
FOC43_RS05705	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FOC43_RS05730	COG0512	Glutamine amidotransferase of anthranilate synthase
FOC43_RS05730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FOC43_RS05740	COG0730	response to heat
FOC43_RS05745	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FOC43_RS05765	COG1238	metal cluster binding
FOC43_RS05775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FOC43_RS05780	COG1360	Flagellar Motor Protein
FOC43_RS05785	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FOC43_RS05790	COG0450	alkyl hydroperoxide reductase
FOC43_RS05800	COG0105	UTP biosynthetic process
FOC43_RS05810	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FOC43_RS05815	COG0416	fatty acid biosynthetic process
FOC43_RS05820	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FOC43_RS05830	COG1570	exodeoxyribonuclease VII activity
FOC43_RS05850	COG2226	methyltransferase
FOC43_RS05865	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
FOC43_RS05875	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FOC43_RS05900	COG0019	diaminopimelate decarboxylase activity
FOC43_RS05910	COG0193	aminoacyl-tRNA hydrolase activity
FOC43_RS05925	COG2076	Multidrug Resistance protein
FOC43_RS05930	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FOC43_RS05935	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FOC43_RS05940	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
FOC43_RS05955	COG4106	trans-aconitate 2-methyltransferase activity
FOC43_RS05975	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
FOC43_RS06000	COG0454	-acetyltransferase
FOC43_RS06050	COG0428	transporter
FOC43_RS06055	COG2189	Belongs to the N(4) N(6)-methyltransferase family
FOC43_RS06075	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FOC43_RS06085	COG0784	Response regulator, receiver
FOC43_RS06085	COG0835	chemotaxis
FOC43_RS06090	COG0643	Histidine kinase
FOC43_RS06090	COG2198	Histidine kinase
FOC43_RS06090	COG0784	Response regulator, receiver
FOC43_RS06095	COG0835	chemotaxis
FOC43_RS06105	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FOC43_RS06115	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FOC43_RS06135	COG2079	MmgE PrpD family protein
FOC43_RS06140	COG0372	Belongs to the citrate synthase family
FOC43_RS06145	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
FOC43_RS06165	COG1077	Cell shape determining protein MreB Mrl
FOC43_RS06170	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FOC43_RS06175	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FOC43_RS06185	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FOC43_RS06190	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FOC43_RS06195	COG1942	4-Oxalocrotonate Tautomerase
FOC43_RS06225	COG2264	protein methyltransferase activity
FOC43_RS06235	COG0418	dihydroorotase activity
FOC43_RS06245	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FOC43_RS06250	COG2194	sulfuric ester hydrolase activity
FOC43_RS06255	COG0708	Exodeoxyribonuclease III
FOC43_RS06265	COG2921	Belongs to the UPF0250 family
FOC43_RS06295	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FOC43_RS06300	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FOC43_RS06320	COG0668	transmembrane transport
FOC43_RS06325	COG0288	reversible hydration of carbon dioxide
FOC43_RS06330	COG0670	Belongs to the BI1 family
FOC43_RS06335	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FOC43_RS06355	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOC43_RS06365	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
FOC43_RS06370	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FOC43_RS06375	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FOC43_RS06380	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FOC43_RS06400	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FOC43_RS06410	COG1968	undecaprenyl-diphosphatase activity
FOC43_RS06420	COG4953	penicillin-binding protein 1C
FOC43_RS06425	COG2373	Large extracellular alpha-helical protein
FOC43_RS06440	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FOC43_RS06440	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FOC43_RS06450	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FOC43_RS06465	COG0243	molybdopterin cofactor binding
FOC43_RS06480	COG1157	protein secretion by the type III secretion system
FOC43_RS06485	COG0302	gtp cyclohydrolase
FOC43_RS06500	COG0242	peptide deformylase activity
FOC43_RS06505	COG0606	chelatase, subunit chli
FOC43_RS06515	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FOC43_RS06515	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FOC43_RS06520	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FOC43_RS06535	COG0861	Integral membrane protein TerC family
FOC43_RS06540	COG2824	Alkylphosphonate utilization operon protein PhnA
FOC43_RS06550	COG1253	flavin adenine dinucleotide binding
FOC43_RS06560	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FOC43_RS06570	COG0848	biopolymer transport protein
FOC43_RS06575	COG0811	peptide transport
FOC43_RS06595	COG1840	ABC-type Fe3 transport system, periplasmic component
FOC43_RS06615	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FOC43_RS06635	COG1971	Probably functions as a manganese efflux pump
FOC43_RS06660	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FOC43_RS06665	COG0602	queuosine metabolic process
FOC43_RS06685	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FOC43_RS06690	COG0254	rRNA binding
FOC43_RS06695	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FOC43_RS06715	COG0436	Aminotransferase
FOC43_RS06720	COG0460	homoserine dehydrogenase
FOC43_RS06730	COG3118	belongs to the thioredoxin family
FOC43_RS06735	COG0492	ferredoxin-NADP+ reductase activity
FOC43_RS06755	COG1121	(ABC) transporter
FOC43_RS06760	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FOC43_RS06770	COG1401	restriction endodeoxyribonuclease activity
FOC43_RS06780	COG0779	Required for maturation of 30S ribosomal subunits
FOC43_RS06800	COG0083	homoserine kinase activity
FOC43_RS06825	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FOC43_RS06830	COG0483	inositol monophosphate 1-phosphatase activity
FOC43_RS06835	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FOC43_RS06845	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FOC43_RS06855	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FOC43_RS06885	COG0037	tRNA processing
FOC43_RS06890	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FOC43_RS06895	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FOC43_RS06900	COG1047	Peptidyl-prolyl cis-trans
FOC43_RS06925	COG0848	biopolymer transport protein
FOC43_RS06930	COG0811	peptide transport
FOC43_RS06935	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FOC43_RS06940	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FOC43_RS06955	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FOC43_RS06960	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FOC43_RS06970	COG1475	DNA binding
FOC43_RS06975	COG1192	Involved in chromosome partitioning
FOC43_RS06980	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FOC43_RS06980	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FOC43_RS07030	COG1793	dna ligase
FOC43_RS07045	COG0148	phosphopyruvate hydratase activity
FOC43_RS07050	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FOC43_RS07055	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FOC43_RS07060	COG1987	bacterial-type flagellum assembly
FOC43_RS07075	COG1218	3'(2'),5'-bisphosphate nucleotidase
FOC43_RS07080	COG0372	Belongs to the citrate synthase family
FOC43_RS07095	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FOC43_RS07105	COG0201	protein transport
FOC43_RS07110	COG0200	Binds to the 23S rRNA
FOC43_RS07115	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FOC43_RS07120	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FOC43_RS07125	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FOC43_RS07130	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FOC43_RS07135	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FOC43_RS07140	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FOC43_RS07145	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FOC43_RS07150	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FOC43_RS07155	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FOC43_RS07160	COG0255	Belongs to the universal ribosomal protein uL29 family
FOC43_RS07165	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FOC43_RS07170	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FOC43_RS07175	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FOC43_RS07180	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FOC43_RS07190	COG0089	rRNA binding
FOC43_RS07200	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FOC43_RS07205	COG0051	transcription antitermination factor activity, RNA binding
FOC43_RS07210	COG1187	pseudouridine synthase activity
FOC43_RS07215	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FOC43_RS07265	COG0066	3-isopropylmalate dehydratase activity
FOC43_RS07275	COG0473	3-isopropylmalate dehydrogenase activity
FOC43_RS07300	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FOC43_RS07310	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
FOC43_RS07325	COG1749	Flagellar hook protein flgE
FOC43_RS07335	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FOC43_RS07340	COG0592	DNA-directed DNA polymerase activity
FOC43_RS07345	COG0187	DNA topoisomerase II activity
FOC43_RS07365	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FOC43_RS07370	COG3162	membrane
FOC43_RS07375	COG2056	Na+-H+ antiporter family
FOC43_RS07380	COG0070	glutamate synthase
FOC43_RS07380	COG0069	glutamate synthase activity
FOC43_RS07380	COG0067	glutamate synthase
FOC43_RS07385	COG0493	'glutamate synthase
FOC43_RS07395	COG1592	Rubrerythrin
FOC43_RS07410	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FOC43_RS07425	COG0179	Fumarylacetoacetate (FAA) hydrolase
FOC43_RS07430	COG0564	pseudouridine synthase activity
FOC43_RS07435	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FOC43_RS07440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FOC43_RS07445	COG1823	symporter activity
FOC43_RS07460	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
FOC43_RS07465	COG0252	asparaginase activity
FOC43_RS07510	COG2890	protein-(glutamine-N5) methyltransferase activity
FOC43_RS07525	COG2814	Major facilitator Superfamily
FOC43_RS07540	COG1217	gtp-binding protein TYPA
FOC43_RS07555	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FOC43_RS07580	COG0471	metal ion transport
FOC43_RS07590	COG1611	Belongs to the LOG family
FOC43_RS07615	COG1776	CheC inhibitor of MCP methylation
FOC43_RS07615	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FOC43_RS07620	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FOC43_RS07625	COG1191	sigma factor activity
FOC43_RS07635	COG0455	bacterial-type flagellum organization
FOC43_RS07640	COG1419	protein localization to endoplasmic reticulum
FOC43_RS07645	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FOC43_RS07650	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FOC43_RS07655	COG0402	S-adenosylhomocysteine deaminase activity
FOC43_RS07660	COG0616	signal peptide processing
FOC43_RS07675	COG2703	oxygen carrier activity
FOC43_RS07680	COG2703	oxygen carrier activity
FOC43_RS07690	COG1139	Iron-sulfur cluster binding protein
FOC43_RS07695	COG0247	lactate metabolic process
FOC43_RS07700	COG1620	l-lactate permease
FOC43_RS07710	COG1271	oxidase subunit
FOC43_RS07715	COG1294	oxidase, subunit
FOC43_RS07730	COG1794	racemase activity, acting on amino acids and derivatives
FOC43_RS07735	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FOC43_RS07740	COG1027	Aspartate ammonia-lyase
FOC43_RS07745	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FOC43_RS07765	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FOC43_RS07770	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FOC43_RS07790	COG0577	efflux transmembrane transporter activity
FOC43_RS07790	COG1136	(ABC) transporter
FOC43_RS07795	COG0577	efflux transmembrane transporter activity
FOC43_RS07795	COG1136	(ABC) transporter
FOC43_RS07815	COG0672	)-iron permease
FOC43_RS07825	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FOC43_RS07830	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FOC43_RS07835	COG0791	NLP P60 protein
FOC43_RS07840	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FOC43_RS07845	COG0024	Methionine aminopeptidase
FOC43_RS07860	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FOC43_RS07860	COG3218	ABC-type transport auxiliary lipoprotein component
FOC43_RS07865	COG1127	ABC transporter
FOC43_RS07870	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FOC43_RS07875	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FOC43_RS07890	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FOC43_RS07895	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FOC43_RS07910	COG0358	DNA primase activity
FOC43_RS07920	COG0328	RNA-DNA hybrid ribonuclease activity
FOC43_RS07985	COG0848	biopolymer transport protein
FOC43_RS07990	COG0811	peptide transport
FOC43_RS08005	COG0814	amino acid
FOC43_RS08010	COG1760	l-serine dehydratase
FOC43_RS08020	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FOC43_RS08020	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FOC43_RS08070	COG1194	a g-specific adenine glycosylase
FOC43_RS08075	COG0477	Major facilitator Superfamily
FOC43_RS08085	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FOC43_RS08090	COG1120	ATPase activity
FOC43_RS08095	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FOC43_RS08100	COG4771	TonB-dependent receptor
FOC43_RS08105	COG0748	coenzyme F420 binding
FOC43_RS08110	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FOC43_RS08115	COG0268	Binds directly to 16S ribosomal RNA
FOC43_RS08120	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FOC43_RS08125	COG2046	Belongs to the sulfate adenylyltransferase family
FOC43_RS08140	COG0489	protein tyrosine kinase activity
FOC43_RS08145	COG2171	N-acyltransferase activity
FOC43_RS08155	COG0140	phosphoribosyl-ATP diphosphatase activity
FOC43_RS08155	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FOC43_RS08175	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FOC43_RS08175	COG0131	Imidazoleglycerol-phosphate dehydratase
FOC43_RS08185	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FOC43_RS08190	COG0203	ribosomal protein L17
FOC43_RS08195	COG0202	RNA polymerase activity
FOC43_RS08205	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FOC43_RS08215	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FOC43_RS08220	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FOC43_RS08270	COG4615	Cyclic peptide transporter
FOC43_RS08285	COG0277	FAD linked oxidase domain protein
FOC43_RS08295	COG0601	transmembrane transport
FOC43_RS08300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FOC43_RS08305	COG4172	Belongs to the ABC transporter superfamily
FOC43_RS08315	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FOC43_RS08325	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FOC43_RS08360	COG0839	Belongs to the complex I subunit 6 family
FOC43_RS08370	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FOC43_RS08375	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FOC43_RS08390	COG0840	transmembrane signaling receptor activity
FOC43_RS08415	COG0701	Predicted permease
FOC43_RS08435	COG3545	Serine hydrolase
FOC43_RS08445	COG3177	Filamentation induced by cAMP protein fic
FOC43_RS08465	COG1064	alcohol dehydrogenase
FOC43_RS08480	COG2249	NAD(P)H dehydrogenase (quinone) activity
FOC43_RS08495	COG1984	allophanate hydrolase subunit 2
FOC43_RS08500	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FOC43_RS08505	COG1914	H( )-stimulated, divalent metal cation uptake system
FOC43_RS08515	COG2998	abc-type tungstate transport system, permease component
FOC43_RS08520	COG4662	Binding-protein-dependent transport system inner membrane component
FOC43_RS08525	COG3839	Belongs to the ABC transporter superfamily
FOC43_RS08540	COG0166	Belongs to the GPI family
FOC43_RS08545	COG0783	Belongs to the Dps family
FOC43_RS08560	COG2992	FlgJ-related protein
FOC43_RS08565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FOC43_RS08570	COG0237	dephospho-CoA kinase activity
FOC43_RS08575	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FOC43_RS08585	COG5268	conjugation
FOC43_RS08590	COG3838	Conjugal transfer protein Trbc
FOC43_RS08595	COG4962	Type ii secretion system protein e
FOC43_RS08620	COG0675	Transposase, IS605 OrfB family
FOC43_RS08645	COG1192	Involved in chromosome partitioning
FOC43_RS08675	COG0675	Transposase, IS605 OrfB family
FOC43_RS08700	COG1192	Involved in chromosome partitioning
FOC43_RS08730	COG0675	Transposase, IS605 OrfB family
FOC43_RS08770	COG3504	Conjugal transfer protein
FOC43_RS08775	COG3701	Conjugal transfer protein