locus-tag	class	description
BLD37_RS00020	COG1395	domain, Protein
BLD37_RS00040	COG1121	(ABC) transporter
BLD37_RS00045	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BLD37_RS00055	COG1401	restriction endodeoxyribonuclease activity
BLD37_RS00085	COG0083	homoserine kinase activity
BLD37_RS00110	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BLD37_RS00115	COG0483	inositol monophosphate 1-phosphatase activity
BLD37_RS00120	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BLD37_RS00130	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BLD37_RS00140	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BLD37_RS00170	COG0037	tRNA processing
BLD37_RS00175	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BLD37_RS00180	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BLD37_RS00185	COG1047	Peptidyl-prolyl cis-trans
BLD37_RS00210	COG0848	biopolymer transport protein
BLD37_RS00215	COG0811	peptide transport
BLD37_RS00220	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BLD37_RS00225	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BLD37_RS00240	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BLD37_RS00245	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BLD37_RS00255	COG1475	DNA binding
BLD37_RS00260	COG1192	Involved in chromosome partitioning
BLD37_RS00265	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BLD37_RS00265	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BLD37_RS00315	COG1793	dna ligase
BLD37_RS00330	COG0148	phosphopyruvate hydratase activity
BLD37_RS00335	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BLD37_RS00340	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BLD37_RS00345	COG1987	bacterial-type flagellum assembly
BLD37_RS00360	COG1218	3'(2'),5'-bisphosphate nucleotidase
BLD37_RS00365	COG0372	Belongs to the citrate synthase family
BLD37_RS00380	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BLD37_RS00390	COG0201	protein transport
BLD37_RS00395	COG0200	Binds to the 23S rRNA
BLD37_RS00400	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BLD37_RS00405	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BLD37_RS00410	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BLD37_RS00415	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BLD37_RS00420	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BLD37_RS00425	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BLD37_RS00430	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BLD37_RS00435	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BLD37_RS00440	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BLD37_RS00445	COG0255	Belongs to the universal ribosomal protein uL29 family
BLD37_RS00450	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BLD37_RS00455	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BLD37_RS00460	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
BLD37_RS00465	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BLD37_RS00480	COG0088	Forms part of the polypeptide exit tunnel
BLD37_RS00485	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BLD37_RS00490	COG0051	transcription antitermination factor activity, RNA binding
BLD37_RS00495	COG1187	pseudouridine synthase activity
BLD37_RS00500	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BLD37_RS00560	COG0066	3-isopropylmalate dehydratase activity
BLD37_RS00570	COG0473	3-isopropylmalate dehydrogenase activity
BLD37_RS00595	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BLD37_RS00600	COG0492	ferredoxin-NADP+ reductase activity
BLD37_RS00605	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BLD37_RS00610	COG0425	Belongs to the sulfur carrier protein TusA family
BLD37_RS00615	COG2391	methyltransferase activity
BLD37_RS00630	COG1749	Flagellar hook protein flgE
BLD37_RS00640	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
BLD37_RS00645	COG0592	DNA-directed DNA polymerase activity
BLD37_RS00650	COG0187	DNA topoisomerase II activity
BLD37_RS00680	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BLD37_RS00685	COG3162	membrane
BLD37_RS00690	COG2056	Na+-H+ antiporter family
BLD37_RS00695	COG0070	glutamate synthase
BLD37_RS00695	COG0069	glutamate synthase activity
BLD37_RS00695	COG0067	glutamate synthase
BLD37_RS00700	COG0493	'glutamate synthase
BLD37_RS00710	COG1592	Rubrerythrin
BLD37_RS00725	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BLD37_RS00740	COG0179	Fumarylacetoacetate (FAA) hydrolase
BLD37_RS00745	COG0564	pseudouridine synthase activity
BLD37_RS00750	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BLD37_RS00755	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BLD37_RS00760	COG1823	symporter activity
BLD37_RS00775	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
BLD37_RS00780	COG0252	asparaginase activity
BLD37_RS00865	COG2814	Major facilitator Superfamily
BLD37_RS00880	COG1217	gtp-binding protein TYPA
BLD37_RS00895	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BLD37_RS00920	COG0471	metal ion transport
BLD37_RS00930	COG1611	Belongs to the LOG family
BLD37_RS00955	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BLD37_RS00955	COG1776	CheC inhibitor of MCP methylation
BLD37_RS00960	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BLD37_RS00965	COG1191	sigma factor activity
BLD37_RS00975	COG0455	bacterial-type flagellum organization
BLD37_RS00980	COG1419	protein localization to endoplasmic reticulum
BLD37_RS00985	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BLD37_RS00990	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BLD37_RS00995	COG0402	S-adenosylhomocysteine deaminase activity
BLD37_RS01000	COG0616	signal peptide processing
BLD37_RS01015	COG2703	oxygen carrier activity
BLD37_RS01020	COG2703	oxygen carrier activity
BLD37_RS01030	COG1139	Iron-sulfur cluster binding protein
BLD37_RS01035	COG0247	lactate metabolic process
BLD37_RS01040	COG1620	l-lactate permease
BLD37_RS01050	COG1271	oxidase subunit
BLD37_RS01055	COG1294	oxidase, subunit
BLD37_RS01075	COG1794	racemase activity, acting on amino acids and derivatives
BLD37_RS01080	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
BLD37_RS01085	COG1027	Aspartate ammonia-lyase
BLD37_RS01090	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BLD37_RS01110	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BLD37_RS01115	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BLD37_RS01135	COG0577	efflux transmembrane transporter activity
BLD37_RS01135	COG1136	(ABC) transporter
BLD37_RS01140	COG0577	efflux transmembrane transporter activity
BLD37_RS01140	COG1136	(ABC) transporter
BLD37_RS01160	COG0672	)-iron permease
BLD37_RS01170	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BLD37_RS01175	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
BLD37_RS01180	COG0791	NLP P60 protein
BLD37_RS01185	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BLD37_RS01190	COG0024	Methionine aminopeptidase
BLD37_RS01205	COG3218	ABC-type transport auxiliary lipoprotein component
BLD37_RS01205	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BLD37_RS01210	COG1127	ABC transporter
BLD37_RS01215	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BLD37_RS01220	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BLD37_RS01235	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BLD37_RS01240	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BLD37_RS01255	COG0358	DNA primase activity
BLD37_RS01265	COG0328	RNA-DNA hybrid ribonuclease activity
BLD37_RS01325	COG0848	biopolymer transport protein
BLD37_RS01330	COG0811	peptide transport
BLD37_RS01345	COG0814	amino acid
BLD37_RS01350	COG1760	l-serine dehydratase
BLD37_RS01360	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BLD37_RS01360	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BLD37_RS01405	COG2703	oxygen carrier activity
BLD37_RS01415	COG1194	a g-specific adenine glycosylase
BLD37_RS01420	COG0477	Major facilitator Superfamily
BLD37_RS01430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BLD37_RS01435	COG1120	ATPase activity
BLD37_RS01440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BLD37_RS01445	COG4771	TonB-dependent receptor
BLD37_RS01450	COG0748	coenzyme F420 binding
BLD37_RS01455	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
BLD37_RS01460	COG0268	Binds directly to 16S ribosomal RNA
BLD37_RS01465	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BLD37_RS01470	COG2046	Belongs to the sulfate adenylyltransferase family
BLD37_RS01485	COG0489	protein tyrosine kinase activity
BLD37_RS01490	COG2171	N-acyltransferase activity
BLD37_RS01500	COG0140	phosphoribosyl-ATP diphosphatase activity
BLD37_RS01500	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BLD37_RS01520	COG0131	Imidazoleglycerol-phosphate dehydratase
BLD37_RS01520	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BLD37_RS01530	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
BLD37_RS01535	COG0203	ribosomal protein L17
BLD37_RS01540	COG0202	RNA polymerase activity
BLD37_RS01550	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BLD37_RS01560	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BLD37_RS01565	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BLD37_RS01620	COG4615	Cyclic peptide transporter
BLD37_RS01635	COG0277	FAD linked oxidase domain protein
BLD37_RS01645	COG0601	transmembrane transport
BLD37_RS01650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BLD37_RS01655	COG4172	Belongs to the ABC transporter superfamily
BLD37_RS01665	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BLD37_RS01675	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BLD37_RS01710	COG0839	Belongs to the complex I subunit 6 family
BLD37_RS01720	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BLD37_RS01725	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BLD37_RS01775	COG2249	NAD(P)H dehydrogenase (quinone) activity
BLD37_RS01785	COG3545	Serine hydrolase
BLD37_RS01800	COG0732	type I restriction modification DNA specificity domain
BLD37_RS01805	COG1204	response to ionizing radiation
BLD37_RS01820	COG1064	alcohol dehydrogenase
BLD37_RS01835	COG2249	NAD(P)H dehydrogenase (quinone) activity
BLD37_RS01850	COG1984	allophanate hydrolase subunit 2
BLD37_RS01855	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BLD37_RS01860	COG1914	H( )-stimulated, divalent metal cation uptake system
BLD37_RS01870	COG2998	abc-type tungstate transport system, permease component
BLD37_RS01875	COG4662	Binding-protein-dependent transport system inner membrane component
BLD37_RS01880	COG3839	Belongs to the ABC transporter superfamily
BLD37_RS01900	COG0783	Belongs to the Dps family
BLD37_RS01915	COG2992	FlgJ-related protein
BLD37_RS01920	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BLD37_RS01925	COG0237	dephospho-CoA kinase activity
BLD37_RS01930	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BLD37_RS01940	COG3069	C4-dicarboxylate transmembrane transporter activity
BLD37_RS01960	COG0303	'Molybdopterin
BLD37_RS01965	COG0314	molybdopterin synthase activity
BLD37_RS01995	COG0243	molybdopterin cofactor binding
BLD37_RS02005	COG0437	4 iron, 4 sulfur cluster binding
BLD37_RS02025	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BLD37_RS02035	COG0425	Belongs to the sulfur carrier protein TusA family
BLD37_RS02040	COG0709	Synthesizes selenophosphate from selenide and ATP
BLD37_RS02050	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BLD37_RS02055	COG0425	Belongs to the sulfur carrier protein TusA family
BLD37_RS02070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BLD37_RS02090	COG0505	Belongs to the CarA family
BLD37_RS02105	COG0745	RESPONSE REGULATOR receiver
BLD37_RS02150	COG2887	Belongs to the helicase family. UvrD subfamily
BLD37_RS02155	COG1074	ATP-dependent DNA helicase activity
BLD37_RS02170	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BLD37_RS02175	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BLD37_RS02185	COG0546	phosphoglycolate phosphatase activity
BLD37_RS02220	COG1459	type II secretion system
BLD37_RS02250	COG3951	Flagellar rod assembly protein muramidase FlgJ
BLD37_RS02255	COG1706	bacterial-type flagellum-dependent cell motility
BLD37_RS02275	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BLD37_RS02295	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BLD37_RS02345	COG0517	IMP dehydrogenase activity
BLD37_RS02345	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BLD37_RS02360	COG1218	3'(2'),5'-bisphosphate nucleotidase
BLD37_RS02365	COG0175	sulfate reduction
BLD37_RS02370	COG2895	sulfate adenylyltransferase (ATP) activity
BLD37_RS02375	COG3273	potassium ion transport
BLD37_RS02375	COG0471	metal ion transport
BLD37_RS02380	COG0529	Catalyzes the synthesis of activated sulfate
BLD37_RS02405	COG2124	cytochrome p450
BLD37_RS02415	COG0736	holo-[acyl-carrier-protein] synthase activity
BLD37_RS02420	COG1580	Controls the rotational direction of flagella during chemotaxis
BLD37_RS02440	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
BLD37_RS02450	COG0126	phosphoglycerate kinase activity
BLD37_RS02460	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BLD37_RS02465	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
BLD37_RS02470	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
BLD37_RS02475	COG1918	ferrous iron import across plasma membrane
BLD37_RS02485	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BLD37_RS02495	COG3069	C4-dicarboxylate transmembrane transporter activity
BLD37_RS02500	COG0251	oxidation-reduction process
BLD37_RS02505	COG2964	Protein conserved in bacteria
BLD37_RS02515	COG0753	catalase activity
BLD37_RS02530	COG0716	FMN binding
BLD37_RS02550	COG3276	selenocysteine insertion sequence binding
BLD37_RS02565	COG2814	Major facilitator Superfamily
BLD37_RS02590	COG2853	Lipoprotein
BLD37_RS02600	COG2252	PERMEase
BLD37_RS02605	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BLD37_RS02615	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BLD37_RS02620	COG0114	fumarate hydratase activity
BLD37_RS02625	COG0628	permease
BLD37_RS02650	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
BLD37_RS02660	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
BLD37_RS02675	COG4607	ABC-type enterochelin transport system periplasmic component
BLD37_RS02680	COG4604	ABC transporter, ATP-binding protein
BLD37_RS02685	COG4605	iron ion homeostasis
BLD37_RS02690	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BLD37_RS02715	COG0575	Belongs to the CDS family
BLD37_RS02735	COG2165	general secretion pathway protein
BLD37_RS02750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BLD37_RS02750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BLD37_RS02770	COG1028	Short-chain dehydrogenase reductase Sdr
BLD37_RS02775	COG1083	cytidylyl-transferase
BLD37_RS02785	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
BLD37_RS02790	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
BLD37_RS02795	COG2089	acid synthase
BLD37_RS02830	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BLD37_RS02835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BLD37_RS02845	COG2089	acid synthase
BLD37_RS02860	COG0107	imidazoleglycerol-phosphate synthase activity
BLD37_RS02865	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BLD37_RS02870	COG3980	spore coat polysaccharide biosynthesis protein
BLD37_RS02875	COG1083	cytidylyl-transferase
BLD37_RS02885	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BLD37_RS02925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BLD37_RS02960	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BLD37_RS02965	COG1086	Polysaccharide biosynthesis protein
BLD37_RS02975	COG0511	ligase activity, forming carbon-carbon bonds
BLD37_RS02980	COG0439	Biotin carboxylase
BLD37_RS02985	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BLD37_RS02990	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BLD37_RS02995	COG0280	phosphate acetyltransferase
BLD37_RS02995	COG0281	malic enzyme
BLD37_RS03000	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BLD37_RS03005	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BLD37_RS03010	COG0569	domain protein
BLD37_RS03015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BLD37_RS03035	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BLD37_RS03035	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BLD37_RS03045	COG0028	Belongs to the TPP enzyme family
BLD37_RS03050	COG0440	acetolactate synthase activity
BLD37_RS03065	COG0805	protein transport
BLD37_RS03075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BLD37_RS03080	COG0494	nUDIX hydrolase
BLD37_RS03085	COG0527	aspartate kinase activity
BLD37_RS03100	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BLD37_RS03105	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
BLD37_RS03125	COG2890	protein-(glutamine-N5) methyltransferase activity
BLD37_RS03135	COG2860	membrane
BLD37_RS03145	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BLD37_RS03150	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BLD37_RS03155	COG0191	fructose-bisphosphate aldolase activity
BLD37_RS03175	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BLD37_RS03190	COG1942	4-Oxalocrotonate Tautomerase
BLD37_RS03200	COG0739	heme binding
BLD37_RS03205	COG0751	glycine-tRNA ligase activity
BLD37_RS03220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BLD37_RS03220	COG0475	glutathione-regulated potassium exporter activity
BLD37_RS03225	COG0789	Transcriptional regulator
BLD37_RS03230	COG0484	heat shock protein binding
BLD37_RS03235	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BLD37_RS03240	COG0745	RESPONSE REGULATOR receiver
BLD37_RS03245	COG0642	Histidine kinase
BLD37_RS03290	COG2703	oxygen carrier activity
BLD37_RS03295	COG0745	RESPONSE REGULATOR receiver
BLD37_RS03300	COG0642	Histidine kinase
BLD37_RS03315	COG1185	polyribonucleotide nucleotidyltransferase activity
BLD37_RS03340	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
BLD37_RS03345	COG2226	methyltransferase
BLD37_RS03370	COG0731	radical SAM domain protein
BLD37_RS03390	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
BLD37_RS03420	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BLD37_RS03435	COG1496	oxidoreductase activity
BLD37_RS03445	COG0739	heme binding
BLD37_RS03460	COG1295	ribonuclease BN
BLD37_RS03490	COG0552	protein localization to endoplasmic reticulum
BLD37_RS03495	COG0523	cobalamin synthesis protein
BLD37_RS03515	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BLD37_RS03530	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BLD37_RS03565	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BLD37_RS03580	COG1301	dicarboxylic acid transport
BLD37_RS03605	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
BLD37_RS03610	COG0723	plastoquinol--plastocyanin reductase activity
BLD37_RS03615	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BLD37_RS03625	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BLD37_RS03630	COG0052	Belongs to the universal ribosomal protein uS2 family
BLD37_RS03640	COG1136	(ABC) transporter
BLD37_RS03655	COG0194	GDP metabolic process
BLD37_RS03660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BLD37_RS03665	COG0018	arginyl-trna synthetase
BLD37_RS03685	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BLD37_RS03690	COG0586	Pfam SNARE associated Golgi protein
BLD37_RS03695	COG0039	L-malate dehydrogenase activity
BLD37_RS03705	COG3610	response to peptide
BLD37_RS03725	COG2217	Heavy metal translocating P-type atpase
BLD37_RS03730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BLD37_RS03735	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BLD37_RS03740	COG2217	Heavy metal translocating P-type atpase
BLD37_RS03755	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BLD37_RS03780	COG1216	Glycosyl transferase, family 2
BLD37_RS03790	COG1442	glycosyl transferase family 8
BLD37_RS03790	COG1216	Glycosyl transferase, family 2
BLD37_RS03815	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BLD37_RS03820	COG1132	(ABC) transporter
BLD37_RS03825	COG0438	transferase activity, transferring glycosyl groups
BLD37_RS03830	COG1215	transferase activity, transferring glycosyl groups
BLD37_RS03835	COG0438	transferase activity, transferring glycosyl groups
BLD37_RS03845	COG0438	transferase activity, transferring glycosyl groups
BLD37_RS03850	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BLD37_RS03855	COG0110	maltose O-acetyltransferase activity
BLD37_RS03860	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BLD37_RS03865	COG1086	Polysaccharide biosynthesis protein
BLD37_RS03870	COG0745	RESPONSE REGULATOR receiver
BLD37_RS03880	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BLD37_RS03890	COG1183	phosphatidylcholine synthase activity
BLD37_RS03895	COG2833	Protein of unknown function (DUF455)
BLD37_RS03900	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BLD37_RS03905	COG2095	MarC family integral membrane protein
BLD37_RS03910	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BLD37_RS03915	COG0542	response to heat
BLD37_RS03925	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
BLD37_RS03930	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BLD37_RS03970	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BLD37_RS03975	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BLD37_RS03985	COG1028	Short-chain dehydrogenase reductase Sdr
BLD37_RS03995	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BLD37_RS04000	COG1862	Preprotein translocase
BLD37_RS04005	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BLD37_RS04010	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BLD37_RS04035	COG0739	heme binding
BLD37_RS04045	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BLD37_RS04065	COG0352	thiamine-phosphate diphosphorylase activity
BLD37_RS04090	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BLD37_RS04095	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BLD37_RS04105	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BLD37_RS04110	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BLD37_RS04115	COG0629	single-stranded DNA binding
BLD37_RS04120	COG0360	Binds together with S18 to 16S ribosomal RNA
BLD37_RS04125	COG2271	Major facilitator Superfamily
BLD37_RS04140	COG0750	zinc metalloprotease
BLD37_RS04145	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
BLD37_RS04150	COG0778	Nitroreductase
BLD37_RS04155	COG0778	Nitroreductase
BLD37_RS04165	COG1546	Belongs to the CinA family
BLD37_RS04165	COG1058	Belongs to the CinA family
BLD37_RS04170	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
BLD37_RS04175	COG0154	amidase activity
BLD37_RS04180	COG0517	IMP dehydrogenase activity
BLD37_RS04180	COG0516	GMP reductase activity
BLD37_RS04220	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
BLD37_RS04230	COG1193	negative regulation of DNA recombination
BLD37_RS04240	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
BLD37_RS04280	COG0352	thiamine-phosphate diphosphorylase activity
BLD37_RS04305	COG0772	Belongs to the SEDS family
BLD37_RS04310	COG0439	Biotin carboxylase
BLD37_RS04345	COG0481	GTPase activity
BLD37_RS04360	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BLD37_RS04375	COG2204	response regulator
BLD37_RS04380	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BLD37_RS04390	COG4773	Receptor
BLD37_RS04430	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BLD37_RS04430	COG1333	cytochrome c biogenesis protein
BLD37_RS04465	COG0343	queuine tRNA-ribosyltransferase activity
BLD37_RS04485	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BLD37_RS04490	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BLD37_RS04510	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BLD37_RS04515	COG0583	DNA-binding transcription factor activity
BLD37_RS04520	COG2855	membrane
BLD37_RS04530	COG0357	Ribosomal RNA small subunit methyltransferase G
BLD37_RS04535	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BLD37_RS04540	COG0113	porphobilinogen synthase activity
BLD37_RS04545	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BLD37_RS04555	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BLD37_RS04560	COG2181	nitrate reductase activity
BLD37_RS04560	COG0247	lactate metabolic process
BLD37_RS04575	COG3022	response to hydroperoxide
BLD37_RS04585	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLD37_RS04590	COG0477	Major facilitator Superfamily
BLD37_RS04595	COG2195	Cleaves the N-terminal amino acid of tripeptides
BLD37_RS04600	COG1525	nuclease
BLD37_RS04640	COG0733	neurotransmitter:sodium symporter activity
BLD37_RS04645	COG0733	neurotransmitter:sodium symporter activity
BLD37_RS04665	COG0012	GTP binding
BLD37_RS04670	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BLD37_RS04680	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
BLD37_RS04695	COG2201	protein-glutamate methylesterase activity
BLD37_RS04700	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BLD37_RS04705	COG1126	abc transporter atp-binding protein
BLD37_RS04710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLD37_RS04715	COG0765	amino acid transport
BLD37_RS04720	COG0765	amino acid transport
BLD37_RS04725	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BLD37_RS04730	COG1966	Carbon starvation protein
BLD37_RS04735	COG2879	small protein
BLD37_RS04750	COG0776	regulation of translation
BLD37_RS04755	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BLD37_RS04760	COG1999	signal sequence binding
BLD37_RS04785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
BLD37_RS04790	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BLD37_RS04795	COG1115	amino acid carrier protein
BLD37_RS04800	COG1126	abc transporter atp-binding protein
BLD37_RS04805	COG0765	amino acid transport
BLD37_RS04820	COG0537	adenosine 5'-monophosphoramidase activity
BLD37_RS04825	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BLD37_RS04845	COG1185	polyribonucleotide nucleotidyltransferase activity
BLD37_RS04845	COG0539	negative regulation of cytoplasmic translation
BLD37_RS04855	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BLD37_RS04860	COG0745	RESPONSE REGULATOR receiver
BLD37_RS04865	COG2205	protein histidine kinase activity
BLD37_RS04865	COG2202	Pas domain
BLD37_RS04870	COG0488	(ABC) transporter
BLD37_RS04880	COG0303	'Molybdopterin
BLD37_RS04895	COG0512	Glutamine amidotransferase of anthranilate synthase
BLD37_RS04895	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BLD37_RS04905	COG0582	viral genome integration into host DNA
BLD37_RS04935	COG2404	hydrolase activity, acting on ester bonds
BLD37_RS04940	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BLD37_RS04945	COG1959	2 iron, 2 sulfur cluster binding
BLD37_RS04950	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BLD37_RS04955	COG1196	nuclear chromosome segregation
BLD37_RS04955	COG1674	ftsk spoiiie
BLD37_RS04960	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BLD37_RS04980	COG0642	Histidine kinase
BLD37_RS04990	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BLD37_RS05030	COG0765	amino acid transport
BLD37_RS05055	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BLD37_RS05065	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
BLD37_RS05080	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BLD37_RS05085	COG2957	Belongs to the agmatine deiminase family
BLD37_RS05095	COG0840	transmembrane signaling receptor activity
BLD37_RS05100	COG0138	bifunctional purine biosynthesis protein purh
BLD37_RS05105	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BLD37_RS05110	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BLD37_RS05125	COG0706	membrane insertase activity
BLD37_RS05130	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
BLD37_RS05140	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BLD37_RS05160	COG0824	Thioesterase
BLD37_RS05200	COG0803	Belongs to the bacterial solute-binding protein 9 family
BLD37_RS05210	COG0681	Belongs to the peptidase S26 family
BLD37_RS05225	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
BLD37_RS05255	COG0688	phosphatidylethanolamine metabolic process
BLD37_RS05260	COG1408	metallophosphoesterase
BLD37_RS05265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
BLD37_RS05290	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BLD37_RS05300	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BLD37_RS05300	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BLD37_RS05310	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BLD37_RS05315	COG1049	propionate catabolic process, 2-methylcitrate cycle
BLD37_RS05325	COG4221	oxidoreductase activity
BLD37_RS05330	COG1757	Na H antiporter
BLD37_RS05350	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BLD37_RS05390	COG1338	Plays a role in the flagellum-specific transport system
BLD37_RS05415	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BLD37_RS05420	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BLD37_RS05425	COG1663	tetraacyldisaccharide 4'-kinase activity
BLD37_RS05430	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BLD37_RS05445	COG1028	Short-chain dehydrogenase reductase Sdr
BLD37_RS05455	COG0612	Peptidase, M16
BLD37_RS05460	COG0167	dihydroorotate dehydrogenase activity
BLD37_RS05465	COG1132	(ABC) transporter
BLD37_RS05470	COG0215	cysteine-tRNA ligase activity
BLD37_RS05475	COG0728	peptidoglycan biosynthetic process
BLD37_RS05485	COG0632	four-way junction helicase activity
BLD37_RS05490	COG1181	Belongs to the D-alanine--D-alanine ligase family
BLD37_RS05510	COG0318	PFAM AMP-dependent synthetase and ligase
BLD37_RS05510	COG0204	Acyl-transferase
BLD37_RS05520	COG0788	formyltetrahydrofolate deformylase activity
BLD37_RS05525	COG0617	tRNA 3'-terminal CCA addition
BLD37_RS05550	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
BLD37_RS05570	COG3043	anaerobic respiration
BLD37_RS05575	COG0348	domain, Protein
BLD37_RS05580	COG0437	4 iron, 4 sulfur cluster binding
BLD37_RS05590	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BLD37_RS05600	COG0210	DNA helicase
BLD37_RS05615	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BLD37_RS05620	COG2011	ABC-type metal ion transport system permease component
BLD37_RS05625	COG1464	Belongs to the NlpA lipoprotein family
BLD37_RS05630	COG1464	Belongs to the NlpA lipoprotein family
BLD37_RS05635	COG1464	Belongs to the NlpA lipoprotein family
BLD37_RS05645	COG0163	prenyltransferase activity
BLD37_RS05650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BLD37_RS05655	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
BLD37_RS05665	COG1166	arginine decarboxylase activity
BLD37_RS05670	COG1045	serine acetyltransferase
BLD37_RS05675	COG0436	Aminotransferase
BLD37_RS05695	COG0443	Heat shock 70 kDa protein
BLD37_RS05700	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
BLD37_RS05705	COG1420	regulation of RNA biosynthetic process
BLD37_RS05710	COG4771	TonB-dependent receptor
BLD37_RS05720	COG0675	Transposase, IS605 OrfB family
BLD37_RS05745	COG3842	ATPase activity
BLD37_RS05775	COG0598	Magnesium transport protein CorA
BLD37_RS05780	COG0521	Mo-molybdopterin cofactor biosynthetic process
BLD37_RS05790	COG0501	Belongs to the peptidase M48B family
BLD37_RS05795	COG2890	protein-(glutamine-N5) methyltransferase activity
BLD37_RS05810	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BLD37_RS05815	COG0587	DNA-directed DNA polymerase activity
BLD37_RS05820	COG1393	Belongs to the ArsC family
BLD37_RS05825	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BLD37_RS05830	COG2351	hydroxyisourate hydrolase activity
BLD37_RS05835	COG0335	large ribosomal subunit rRNA binding
BLD37_RS05840	COG0336	Belongs to the RNA methyltransferase TrmD family
BLD37_RS05845	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
BLD37_RS05850	COG1837	Belongs to the UPF0109 family
BLD37_RS05855	COG0228	four-way junction DNA binding
BLD37_RS05860	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BLD37_RS05865	COG0564	pseudouridine synthase activity
BLD37_RS05870	COG1519	Transferase
BLD37_RS05880	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BLD37_RS05895	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BLD37_RS05900	COG0826	peptidase U32
BLD37_RS05910	COG0174	glutamine synthetase
BLD37_RS05915	COG4786	Flagellar basal body rod
BLD37_RS05920	COG4786	Flagellar basal body rod
BLD37_RS05925	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BLD37_RS05930	COG0849	cell division
BLD37_RS05935	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BLD37_RS05940	COG0275	rRNA processing
BLD37_RS05955	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
BLD37_RS05960	COG0280	phosphate acetyltransferase
BLD37_RS05970	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BLD37_RS05975	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BLD37_RS06000	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BLD37_RS06005	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BLD37_RS06010	COG1137	ATPase activity
BLD37_RS06015	COG0802	atpase or kinase
BLD37_RS06020	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BLD37_RS06025	COG0137	argininosuccinate synthase activity
BLD37_RS06040	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
BLD37_RS06045	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BLD37_RS06060	COG0006	proline dipeptidase activity
BLD37_RS06095	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BLD37_RS06100	COG0741	lytic transglycosylase activity
BLD37_RS06100	COG1388	LysM domain
BLD37_RS06105	COG0084	hydrolase, TatD family'
BLD37_RS06115	COG0497	DNA recombination
BLD37_RS06130	COG0563	adenylate kinase activity
BLD37_RS06135	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BLD37_RS06140	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BLD37_RS06155	COG0758	DNA mediated transformation
BLD37_RS06165	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BLD37_RS06170	COG0557	exoribonuclease II activity
BLD37_RS06175	COG1466	dna polymerase III delta subunit
BLD37_RS06180	COG0375	protein maturation
BLD37_RS06185	COG0309	Hydrogenase expression formation protein (HypE)
BLD37_RS06190	COG0409	Hydrogenase expression formation protein
BLD37_RS06195	COG0298	carbon dioxide binding
BLD37_RS06205	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BLD37_RS06220	COG0534	Mate efflux family protein
BLD37_RS06235	COG0581	inorganic phosphate transmembrane transporter activity
BLD37_RS06240	COG0573	inorganic phosphate transmembrane transporter activity
BLD37_RS06245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BLD37_RS06250	COG1528	Iron-storage protein
BLD37_RS06255	COG1696	Membrane protein involved in D-alanine export
BLD37_RS06270	COG1538	Outer membrane efflux protein
BLD37_RS06275	COG0577	efflux transmembrane transporter activity
BLD37_RS06275	COG1136	(ABC) transporter
BLD37_RS06280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BLD37_RS06285	COG1473	amidohydrolase
BLD37_RS06300	COG2258	MOSC domain
BLD37_RS06305	COG0733	neurotransmitter:sodium symporter activity
BLD37_RS06310	COG4773	Receptor
BLD37_RS06320	COG0745	RESPONSE REGULATOR receiver
BLD37_RS06325	COG0642	Histidine kinase
BLD37_RS06335	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BLD37_RS06340	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
BLD37_RS06345	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
BLD37_RS06350	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
BLD37_RS06370	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BLD37_RS06375	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BLD37_RS06380	COG1758	RNA polymerase activity
BLD37_RS06385	COG0528	UMP kinase activity
BLD37_RS06400	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BLD37_RS06405	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BLD37_RS06415	COG0564	pseudouridine synthase activity
BLD37_RS06420	COG0772	Belongs to the SEDS family
BLD37_RS06435	COG0305	Participates in initiation and elongation during chromosome replication
BLD37_RS06450	COG0492	ferredoxin-NADP+ reductase activity
BLD37_RS06455	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BLD37_RS06465	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BLD37_RS06485	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BLD37_RS06495	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BLD37_RS06500	COG0181	hydroxymethylbilane synthase activity
BLD37_RS06510	COG0442	prolyl-tRNA aminoacylation
BLD37_RS06515	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BLD37_RS06520	COG0142	geranyltranstransferase activity
BLD37_RS06540	COG1013	pyruvate-flavodoxin oxidoreductase activity
BLD37_RS06545	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BLD37_RS06545	COG0674	pyruvate-flavodoxin oxidoreductase activity
BLD37_RS06555	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BLD37_RS06560	COG0045	succinate-CoA ligase (ADP-forming) activity
BLD37_RS06565	COG0039	L-malate dehydrogenase activity
BLD37_RS06585	COG1815	bacterial-type flagellum-dependent cell motility
BLD37_RS06590	COG1558	bacterial-type flagellum-dependent cell motility
BLD37_RS06595	COG1677	Flagellar hook-basal body complex protein FliE
BLD37_RS06600	COG0768	penicillin binding
BLD37_RS06620	COG0326	Molecular chaperone. Has ATPase activity
BLD37_RS06625	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
BLD37_RS06630	COG0204	Acyl-transferase
BLD37_RS06640	COG0047	phosphoribosylformylglycinamidine synthase activity
BLD37_RS06645	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BLD37_RS06650	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BLD37_RS06655	COG0793	Belongs to the peptidase S41A family
BLD37_RS06665	COG0542	response to heat
BLD37_RS06680	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
BLD37_RS06690	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
BLD37_RS06705	COG0004	ammonium transporteR
BLD37_RS06710	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BLD37_RS06750	COG0049	tRNA binding
BLD37_RS06755	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BLD37_RS06760	COG1012	belongs to the aldehyde dehydrogenase family
BLD37_RS06765	COG3254	rhamnose metabolic process
BLD37_RS06775	COG0738	Major facilitator superfamily
BLD37_RS06780	COG1028	Short-chain dehydrogenase reductase Sdr
BLD37_RS06785	COG2271	Major facilitator Superfamily
BLD37_RS06790	COG2721	sulfolactate sulfo-lyase activity
BLD37_RS06800	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BLD37_RS06820	COG0222	ribosome binding
BLD37_RS06825	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
BLD37_RS06830	COG0081	regulation of translation
BLD37_RS06835	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BLD37_RS06840	COG0250	Participates in transcription elongation, termination and antitermination
BLD37_RS06855	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BLD37_RS06860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BLD37_RS06885	COG1126	abc transporter atp-binding protein
BLD37_RS06890	COG0765	amino acid transport
BLD37_RS06905	COG2346	COG2346, Truncated hemoglobins
BLD37_RS06910	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BLD37_RS06915	COG0612	Peptidase, M16
BLD37_RS06920	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BLD37_RS06930	COG0195	Participates in both transcription termination and antitermination
BLD37_RS06945	COG2121	Domain of unknown function (DUF374)
BLD37_RS06965	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
BLD37_RS06970	COG2176	DNA-directed DNA polymerase activity
BLD37_RS06975	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BLD37_RS06980	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BLD37_RS07000	COG4771	TonB-dependent receptor
BLD37_RS07005	COG2301	Belongs to the HpcH HpaI aldolase family
BLD37_RS07015	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
BLD37_RS07030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BLD37_RS07035	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BLD37_RS07040	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BLD37_RS07050	COG1028	Short-chain dehydrogenase reductase Sdr
BLD37_RS07255	COG4397	Mu-like prophage major head subunit gpT
BLD37_RS07390	COG0840	transmembrane signaling receptor activity
BLD37_RS07405	COG1739	Uncharacterized protein family UPF0029
BLD37_RS07420	COG0488	(ABC) transporter
BLD37_RS07475	COG1132	(ABC) transporter
BLD37_RS07480	COG1160	GTP binding
BLD37_RS07485	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BLD37_RS07490	COG1053	succinate dehydrogenase
BLD37_RS07510	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BLD37_RS07565	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BLD37_RS07570	COG0579	oxidoreductase
BLD37_RS07575	COG0469	pyruvate kinase activity
BLD37_RS07600	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
BLD37_RS07605	COG1160	GTP binding
BLD37_RS07610	COG2076	Multidrug Resistance protein
BLD37_RS07620	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BLD37_RS07625	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
BLD37_RS07640	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BLD37_RS07650	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BLD37_RS07670	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BLD37_RS07675	COG0754	glutathionylspermidine amidase activity
BLD37_RS07685	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BLD37_RS07700	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BLD37_RS07710	COG1538	Outer membrane efflux protein
BLD37_RS07720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BLD37_RS07725	COG1981	membrane
BLD37_RS07730	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BLD37_RS07755	COG0745	RESPONSE REGULATOR receiver
BLD37_RS07760	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BLD37_RS07775	COG1776	CheC inhibitor of MCP methylation
BLD37_RS07775	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BLD37_RS07800	COG0512	Glutamine amidotransferase of anthranilate synthase
BLD37_RS07800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BLD37_RS07810	COG0730	response to heat
BLD37_RS07815	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BLD37_RS07845	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BLD37_RS07850	COG1360	Flagellar Motor Protein
BLD37_RS07855	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BLD37_RS07860	COG0450	alkyl hydroperoxide reductase
BLD37_RS07870	COG0105	UTP biosynthetic process
BLD37_RS07880	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BLD37_RS07885	COG0416	fatty acid biosynthetic process
BLD37_RS07890	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BLD37_RS07900	COG1570	exodeoxyribonuclease VII activity
BLD37_RS07920	COG2226	methyltransferase
BLD37_RS07935	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BLD37_RS07945	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BLD37_RS07970	COG0019	diaminopimelate decarboxylase activity
BLD37_RS07980	COG0193	aminoacyl-tRNA hydrolase activity
BLD37_RS07995	COG2076	Multidrug Resistance protein
BLD37_RS08000	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BLD37_RS08005	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BLD37_RS08010	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
BLD37_RS08025	COG4106	trans-aconitate 2-methyltransferase activity
BLD37_RS08045	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BLD37_RS08070	COG0454	-acetyltransferase
BLD37_RS08110	COG0428	transporter
BLD37_RS08130	COG0835	chemotaxis
BLD37_RS08130	COG0784	Response regulator, receiver
BLD37_RS08135	COG0784	Response regulator, receiver
BLD37_RS08135	COG2198	Histidine kinase
BLD37_RS08135	COG0643	Histidine kinase
BLD37_RS08140	COG0835	chemotaxis
BLD37_RS08150	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
BLD37_RS08160	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BLD37_RS08180	COG2079	MmgE PrpD family protein
BLD37_RS08185	COG0372	Belongs to the citrate synthase family
BLD37_RS08190	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
BLD37_RS08210	COG1077	Cell shape determining protein MreB Mrl
BLD37_RS08215	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BLD37_RS08220	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
BLD37_RS08230	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BLD37_RS08235	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BLD37_RS08240	COG1942	4-Oxalocrotonate Tautomerase
BLD37_RS08270	COG2264	protein methyltransferase activity
BLD37_RS08295	COG2194	sulfuric ester hydrolase activity
BLD37_RS08310	COG2921	Belongs to the UPF0250 family
BLD37_RS08340	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BLD37_RS08345	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BLD37_RS08365	COG0668	transmembrane transport
BLD37_RS08370	COG0288	reversible hydration of carbon dioxide
BLD37_RS08375	COG0670	Belongs to the BI1 family
BLD37_RS08380	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BLD37_RS08400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BLD37_RS08410	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
BLD37_RS08415	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BLD37_RS08420	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BLD37_RS08425	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BLD37_RS08445	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BLD37_RS08455	COG1968	undecaprenyl-diphosphatase activity
BLD37_RS08465	COG4953	penicillin-binding protein 1C
BLD37_RS08470	COG2373	Large extracellular alpha-helical protein
BLD37_RS08485	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BLD37_RS08485	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BLD37_RS08495	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BLD37_RS08525	COG0492	ferredoxin-NADP+ reductase activity
BLD37_RS08530	COG3118	belongs to the thioredoxin family
BLD37_RS08540	COG0460	homoserine dehydrogenase
BLD37_RS08545	COG0436	Aminotransferase
BLD37_RS08565	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BLD37_RS08570	COG0254	rRNA binding
BLD37_RS08575	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BLD37_RS08595	COG0602	queuosine metabolic process
BLD37_RS08600	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BLD37_RS08625	COG1971	Probably functions as a manganese efflux pump
BLD37_RS08645	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BLD37_RS08665	COG1840	ABC-type Fe3 transport system, periplasmic component
BLD37_RS08680	COG4206	TonB-dependent receptor
BLD37_RS08680	COG1629	transport
BLD37_RS08685	COG0811	peptide transport
BLD37_RS08690	COG0848	biopolymer transport protein
BLD37_RS08700	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
BLD37_RS08710	COG1253	flavin adenine dinucleotide binding
BLD37_RS08720	COG2824	Alkylphosphonate utilization operon protein PhnA
BLD37_RS08725	COG0861	Integral membrane protein TerC family
BLD37_RS08740	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BLD37_RS08745	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BLD37_RS08745	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BLD37_RS08755	COG0606	chelatase, subunit chli
BLD37_RS08760	COG0242	peptide deformylase activity
BLD37_RS08775	COG0302	gtp cyclohydrolase
BLD37_RS08780	COG1157	protein secretion by the type III secretion system
BLD37_RS09100	COG1401	restriction endodeoxyribonuclease activity
BLD37_RS09105	COG1401	restriction endodeoxyribonuclease activity
BLD37_RS09140	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity