locus-tag	class	description
A6K30_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6K30_RS00010	COG0592	DNA-directed DNA polymerase activity
A6K30_RS00015	COG0187	DNA topoisomerase II activity
A6K30_RS00045	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6K30_RS00050	COG3162	membrane
A6K30_RS00055	COG2056	Na+-H+ antiporter family
A6K30_RS00060	COG0067	glutamate synthase
A6K30_RS00060	COG0070	glutamate synthase
A6K30_RS00060	COG0069	glutamate synthase activity
A6K30_RS00065	COG0493	'glutamate synthase
A6K30_RS00075	COG1592	Rubrerythrin
A6K30_RS00090	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A6K30_RS00105	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6K30_RS00110	COG0564	pseudouridine synthase activity
A6K30_RS00115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6K30_RS00120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6K30_RS00125	COG1823	symporter activity
A6K30_RS00140	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6K30_RS00145	COG0252	asparaginase activity
A6K30_RS00220	COG2814	Major facilitator Superfamily
A6K30_RS00235	COG1217	gtp-binding protein TYPA
A6K30_RS00250	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A6K30_RS00275	COG0471	metal ion transport
A6K30_RS00285	COG1611	Belongs to the LOG family
A6K30_RS00310	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6K30_RS00310	COG1776	CheC inhibitor of MCP methylation
A6K30_RS00315	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6K30_RS00320	COG1191	sigma factor activity
A6K30_RS00330	COG0455	bacterial-type flagellum organization
A6K30_RS00335	COG1419	protein localization to endoplasmic reticulum
A6K30_RS00340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6K30_RS00345	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6K30_RS00350	COG0402	S-adenosylhomocysteine deaminase activity
A6K30_RS00355	COG0616	signal peptide processing
A6K30_RS00370	COG2703	oxygen carrier activity
A6K30_RS00375	COG2703	oxygen carrier activity
A6K30_RS00385	COG1139	Iron-sulfur cluster binding protein
A6K30_RS00390	COG0247	lactate metabolic process
A6K30_RS00395	COG1620	l-lactate permease
A6K30_RS00405	COG1271	oxidase subunit
A6K30_RS00410	COG1294	oxidase, subunit
A6K30_RS00430	COG1794	racemase activity, acting on amino acids and derivatives
A6K30_RS00435	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6K30_RS00440	COG1027	Aspartate ammonia-lyase
A6K30_RS00445	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6K30_RS00465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6K30_RS00470	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6K30_RS00490	COG0577	efflux transmembrane transporter activity
A6K30_RS00490	COG1136	(ABC) transporter
A6K30_RS00515	COG0672	)-iron permease
A6K30_RS00525	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6K30_RS00530	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6K30_RS00535	COG0791	NLP P60 protein
A6K30_RS00540	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6K30_RS00545	COG0024	Methionine aminopeptidase
A6K30_RS00560	COG3218	ABC-type transport auxiliary lipoprotein component
A6K30_RS00560	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6K30_RS00565	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6K30_RS00570	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6K30_RS00590	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6K30_RS00595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6K30_RS00610	COG0358	DNA primase activity
A6K30_RS00620	COG0328	RNA-DNA hybrid ribonuclease activity
A6K30_RS00680	COG0848	biopolymer transport protein
A6K30_RS00685	COG0811	peptide transport
A6K30_RS00700	COG0814	amino acid
A6K30_RS00705	COG1760	l-serine dehydratase
A6K30_RS00715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6K30_RS00715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6K30_RS00760	COG2703	oxygen carrier activity
A6K30_RS00770	COG1194	a g-specific adenine glycosylase
A6K30_RS00775	COG0477	Major facilitator Superfamily
A6K30_RS00785	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6K30_RS00790	COG1120	ATPase activity
A6K30_RS00795	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6K30_RS00800	COG4771	TonB-dependent receptor
A6K30_RS00805	COG0748	coenzyme F420 binding
A6K30_RS00810	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6K30_RS00815	COG0268	Binds directly to 16S ribosomal RNA
A6K30_RS00820	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6K30_RS00825	COG2046	Belongs to the sulfate adenylyltransferase family
A6K30_RS00840	COG0489	protein tyrosine kinase activity
A6K30_RS00845	COG2171	N-acyltransferase activity
A6K30_RS00855	COG0140	phosphoribosyl-ATP diphosphatase activity
A6K30_RS00855	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6K30_RS00875	COG0131	Imidazoleglycerol-phosphate dehydratase
A6K30_RS00875	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6K30_RS00885	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
A6K30_RS00890	COG0203	ribosomal protein L17
A6K30_RS00895	COG0202	RNA polymerase activity
A6K30_RS00905	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6K30_RS00915	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6K30_RS00920	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6K30_RS00960	COG4735	regulation of single-species biofilm formation
A6K30_RS00985	COG4615	Cyclic peptide transporter
A6K30_RS01000	COG0277	FAD linked oxidase domain protein
A6K30_RS01010	COG0601	transmembrane transport
A6K30_RS01015	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6K30_RS01020	COG4172	Belongs to the ABC transporter superfamily
A6K30_RS01030	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6K30_RS01040	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6K30_RS01075	COG0839	Belongs to the complex I subunit 6 family
A6K30_RS01085	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A6K30_RS01090	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6K30_RS01145	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6K30_RS01155	COG3545	Serine hydrolase
A6K30_RS01165	COG3177	Filamentation induced by cAMP protein fic
A6K30_RS01195	COG1064	alcohol dehydrogenase
A6K30_RS01210	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6K30_RS01225	COG1984	allophanate hydrolase subunit 2
A6K30_RS01230	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A6K30_RS01235	COG1914	H( )-stimulated, divalent metal cation uptake system
A6K30_RS01245	COG2998	abc-type tungstate transport system, permease component
A6K30_RS01250	COG4662	Binding-protein-dependent transport system inner membrane component
A6K30_RS01255	COG3839	Belongs to the ABC transporter superfamily
A6K30_RS01270	COG0166	Belongs to the GPI family
A6K30_RS01275	COG0783	Belongs to the Dps family
A6K30_RS01290	COG2992	FlgJ-related protein
A6K30_RS01295	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6K30_RS01300	COG0237	dephospho-CoA kinase activity
A6K30_RS01305	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6K30_RS01340	COG0303	'Molybdopterin
A6K30_RS01345	COG0314	molybdopterin synthase activity
A6K30_RS01375	COG0243	molybdopterin cofactor binding
A6K30_RS01385	COG0437	4 iron, 4 sulfur cluster binding
A6K30_RS01395	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6K30_RS01415	COG0709	Synthesizes selenophosphate from selenide and ATP
A6K30_RS01425	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6K30_RS01430	COG0425	Belongs to the sulfur carrier protein TusA family
A6K30_RS01445	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6K30_RS01465	COG0505	Belongs to the CarA family
A6K30_RS01480	COG0745	RESPONSE REGULATOR receiver
A6K30_RS01485	COG3278	Belongs to the heme-copper respiratory oxidase family
A6K30_RS01525	COG2887	Belongs to the helicase family. UvrD subfamily
A6K30_RS01530	COG1074	ATP-dependent DNA helicase activity
A6K30_RS01545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6K30_RS01550	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6K30_RS01560	COG0546	phosphoglycolate phosphatase activity
A6K30_RS01595	COG1459	type II secretion system
A6K30_RS01600	COG0730	response to heat
A6K30_RS01625	COG3951	Flagellar rod assembly protein muramidase FlgJ
A6K30_RS01630	COG1706	bacterial-type flagellum-dependent cell motility
A6K30_RS01650	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6K30_RS01670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6K30_RS01720	COG0517	IMP dehydrogenase activity
A6K30_RS01720	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6K30_RS01730	COG1216	Glycosyl transferase, family 2
A6K30_RS01730	COG1442	glycosyl transferase family 8
A6K30_RS01745	COG1083	cytidylyl-transferase
A6K30_RS01750	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A6K30_RS01790	COG2124	cytochrome p450
A6K30_RS01800	COG0736	holo-[acyl-carrier-protein] synthase activity
A6K30_RS01805	COG1580	Controls the rotational direction of flagella during chemotaxis
A6K30_RS01825	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6K30_RS01835	COG0126	phosphoglycerate kinase activity
A6K30_RS01845	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6K30_RS01850	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A6K30_RS01855	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A6K30_RS01860	COG1918	ferrous iron import across plasma membrane
A6K30_RS01870	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6K30_RS01880	COG3069	C4-dicarboxylate transmembrane transporter activity
A6K30_RS01885	COG0251	oxidation-reduction process
A6K30_RS01890	COG2964	Protein conserved in bacteria
A6K30_RS01900	COG0753	catalase activity
A6K30_RS01915	COG0716	FMN binding
A6K30_RS01935	COG3276	selenocysteine insertion sequence binding
A6K30_RS01950	COG2814	Major facilitator Superfamily
A6K30_RS01975	COG2853	Lipoprotein
A6K30_RS01985	COG2252	PERMEase
A6K30_RS01990	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A6K30_RS02000	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6K30_RS02005	COG0114	fumarate hydratase activity
A6K30_RS02010	COG0628	permease
A6K30_RS02035	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6K30_RS02045	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A6K30_RS02060	COG4607	ABC-type enterochelin transport system periplasmic component
A6K30_RS02065	COG4604	ABC transporter, ATP-binding protein
A6K30_RS02070	COG4605	iron ion homeostasis
A6K30_RS02075	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6K30_RS02100	COG0575	Belongs to the CDS family
A6K30_RS02115	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6K30_RS02120	COG2165	general secretion pathway protein
A6K30_RS02170	COG1028	Short-chain dehydrogenase reductase Sdr
A6K30_RS02175	COG1083	cytidylyl-transferase
A6K30_RS02185	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6K30_RS02190	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A6K30_RS02195	COG2089	acid synthase
A6K30_RS02225	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6K30_RS02230	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6K30_RS02255	COG0107	imidazoleglycerol-phosphate synthase activity
A6K30_RS02260	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6K30_RS02265	COG3980	spore coat polysaccharide biosynthesis protein
A6K30_RS02270	COG1083	cytidylyl-transferase
A6K30_RS02295	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6K30_RS02320	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6K30_RS02355	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6K30_RS02360	COG1086	Polysaccharide biosynthesis protein
A6K30_RS02370	COG0511	ligase activity, forming carbon-carbon bonds
A6K30_RS02375	COG0439	Biotin carboxylase
A6K30_RS02380	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6K30_RS02385	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6K30_RS02390	COG0281	malic enzyme
A6K30_RS02390	COG0280	phosphate acetyltransferase
A6K30_RS02395	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6K30_RS02400	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A6K30_RS02405	COG0569	domain protein
A6K30_RS02410	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6K30_RS02430	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6K30_RS02430	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6K30_RS02440	COG0028	Belongs to the TPP enzyme family
A6K30_RS02445	COG0440	acetolactate synthase activity
A6K30_RS02460	COG0805	protein transport
A6K30_RS02470	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6K30_RS02475	COG0494	nUDIX hydrolase
A6K30_RS02480	COG0527	aspartate kinase activity
A6K30_RS02495	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6K30_RS02500	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6K30_RS02520	COG2890	protein-(glutamine-N5) methyltransferase activity
A6K30_RS02530	COG2860	membrane
A6K30_RS02540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6K30_RS02545	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6K30_RS02550	COG0191	fructose-bisphosphate aldolase activity
A6K30_RS02570	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6K30_RS02585	COG1942	4-Oxalocrotonate Tautomerase
A6K30_RS02600	COG1185	polyribonucleotide nucleotidyltransferase activity
A6K30_RS02625	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6K30_RS02630	COG2226	methyltransferase
A6K30_RS02655	COG0731	radical SAM domain protein
A6K30_RS02675	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6K30_RS02700	COG0739	heme binding
A6K30_RS02705	COG0751	glycine-tRNA ligase activity
A6K30_RS02720	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6K30_RS02720	COG0475	glutathione-regulated potassium exporter activity
A6K30_RS02725	COG0789	Transcriptional regulator
A6K30_RS02730	COG0484	heat shock protein binding
A6K30_RS02735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6K30_RS02740	COG0745	RESPONSE REGULATOR receiver
A6K30_RS02745	COG0642	Histidine kinase
A6K30_RS02790	COG2703	oxygen carrier activity
A6K30_RS02795	COG0745	RESPONSE REGULATOR receiver
A6K30_RS02800	COG0642	Histidine kinase
A6K30_RS02820	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6K30_RS02835	COG1496	oxidoreductase activity
A6K30_RS02845	COG0739	heme binding
A6K30_RS02860	COG1295	ribonuclease BN
A6K30_RS02890	COG0552	protein localization to endoplasmic reticulum
A6K30_RS02895	COG0523	cobalamin synthesis protein
A6K30_RS02915	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A6K30_RS02930	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6K30_RS02965	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6K30_RS02980	COG1301	dicarboxylic acid transport
A6K30_RS03005	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A6K30_RS03010	COG0723	plastoquinol--plastocyanin reductase activity
A6K30_RS03015	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6K30_RS03025	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6K30_RS03030	COG0052	Belongs to the universal ribosomal protein uS2 family
A6K30_RS03040	COG1136	(ABC) transporter
A6K30_RS03055	COG0194	GDP metabolic process
A6K30_RS03060	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6K30_RS03065	COG0018	arginyl-trna synthetase
A6K30_RS03075	COG2076	Multidrug Resistance protein
A6K30_RS03080	COG0217	transcriptional regulatory protein
A6K30_RS03085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6K30_RS03100	COG0586	Pfam SNARE associated Golgi protein
A6K30_RS03105	COG0039	L-malate dehydrogenase activity
A6K30_RS03115	COG3610	response to peptide
A6K30_RS03135	COG2217	Heavy metal translocating P-type atpase
A6K30_RS03140	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6K30_RS03145	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6K30_RS03150	COG2217	Heavy metal translocating P-type atpase
A6K30_RS03165	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6K30_RS03170	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6K30_RS03195	COG1216	Glycosyl transferase, family 2
A6K30_RS03205	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
A6K30_RS03230	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6K30_RS03240	COG0028	Belongs to the TPP enzyme family
A6K30_RS03280	COG0859	PFAM glycosyl transferase family 9
A6K30_RS03290	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6K30_RS03295	COG1132	(ABC) transporter
A6K30_RS03300	COG0438	transferase activity, transferring glycosyl groups
A6K30_RS03305	COG1215	transferase activity, transferring glycosyl groups
A6K30_RS03310	COG0438	transferase activity, transferring glycosyl groups
A6K30_RS03320	COG0438	transferase activity, transferring glycosyl groups
A6K30_RS03325	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6K30_RS03330	COG0110	maltose O-acetyltransferase activity
A6K30_RS03335	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6K30_RS03340	COG1086	Polysaccharide biosynthesis protein
A6K30_RS03345	COG0745	RESPONSE REGULATOR receiver
A6K30_RS03355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6K30_RS03365	COG1183	phosphatidylcholine synthase activity
A6K30_RS03370	COG2833	Protein of unknown function (DUF455)
A6K30_RS03375	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6K30_RS03380	COG2095	MarC family integral membrane protein
A6K30_RS03385	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A6K30_RS03390	COG0542	response to heat
A6K30_RS03400	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6K30_RS03405	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6K30_RS03445	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A6K30_RS03450	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6K30_RS03460	COG1028	Short-chain dehydrogenase reductase Sdr
A6K30_RS03470	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6K30_RS03475	COG1862	Preprotein translocase
A6K30_RS03480	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6K30_RS03485	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6K30_RS03510	COG0739	heme binding
A6K30_RS03520	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6K30_RS03540	COG0352	thiamine-phosphate diphosphorylase activity
A6K30_RS03565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6K30_RS03570	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
A6K30_RS03585	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6K30_RS03590	COG0629	single-stranded DNA binding
A6K30_RS03595	COG0360	Binds together with S18 to 16S ribosomal RNA
A6K30_RS03600	COG2271	Major facilitator Superfamily
A6K30_RS03615	COG0750	zinc metalloprotease
A6K30_RS03620	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6K30_RS03625	COG0778	Nitroreductase
A6K30_RS03630	COG0778	Nitroreductase
A6K30_RS03640	COG1546	Belongs to the CinA family
A6K30_RS03640	COG1058	Belongs to the CinA family
A6K30_RS03645	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6K30_RS03650	COG0154	amidase activity
A6K30_RS03655	COG0516	GMP reductase activity
A6K30_RS03655	COG0517	IMP dehydrogenase activity
A6K30_RS03705	COG1193	negative regulation of DNA recombination
A6K30_RS03715	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6K30_RS03755	COG0352	thiamine-phosphate diphosphorylase activity
A6K30_RS03780	COG0772	Belongs to the SEDS family
A6K30_RS03785	COG0439	Biotin carboxylase
A6K30_RS03835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6K30_RS03850	COG2204	response regulator
A6K30_RS03855	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6K30_RS03865	COG4773	Receptor
A6K30_RS03905	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6K30_RS03905	COG1333	cytochrome c biogenesis protein
A6K30_RS03935	COG0343	queuine tRNA-ribosyltransferase activity
A6K30_RS03955	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6K30_RS03960	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6K30_RS03985	COG0583	DNA-binding transcription factor activity
A6K30_RS03990	COG2855	membrane
A6K30_RS04000	COG0357	Ribosomal RNA small subunit methyltransferase G
A6K30_RS04005	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6K30_RS04010	COG0113	porphobilinogen synthase activity
A6K30_RS04015	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6K30_RS04025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6K30_RS04030	COG0247	lactate metabolic process
A6K30_RS04030	COG2181	nitrate reductase activity
A6K30_RS04045	COG3022	response to hydroperoxide
A6K30_RS04055	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6K30_RS04060	COG0477	Major facilitator Superfamily
A6K30_RS04065	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6K30_RS04070	COG1525	nuclease
A6K30_RS04110	COG0733	neurotransmitter:sodium symporter activity
A6K30_RS04115	COG0733	neurotransmitter:sodium symporter activity
A6K30_RS04135	COG0012	GTP binding
A6K30_RS04140	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6K30_RS04150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6K30_RS04165	COG2201	protein-glutamate methylesterase activity
A6K30_RS04170	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6K30_RS04175	COG1126	abc transporter atp-binding protein
A6K30_RS04180	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6K30_RS04185	COG0765	amino acid transport
A6K30_RS04190	COG0765	amino acid transport
A6K30_RS04195	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6K30_RS04200	COG1966	Carbon starvation protein
A6K30_RS04205	COG2879	small protein
A6K30_RS04220	COG0776	regulation of translation
A6K30_RS04225	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6K30_RS04230	COG1999	signal sequence binding
A6K30_RS04255	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6K30_RS04260	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6K30_RS04265	COG1115	amino acid carrier protein
A6K30_RS04270	COG1126	abc transporter atp-binding protein
A6K30_RS04275	COG0765	amino acid transport
A6K30_RS04290	COG0537	adenosine 5'-monophosphoramidase activity
A6K30_RS04295	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6K30_RS04325	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6K30_RS04330	COG0745	RESPONSE REGULATOR receiver
A6K30_RS04335	COG2205	protein histidine kinase activity
A6K30_RS04335	COG2202	Pas domain
A6K30_RS04340	COG0488	(ABC) transporter
A6K30_RS04350	COG0303	'Molybdopterin
A6K30_RS04365	COG0512	Glutamine amidotransferase of anthranilate synthase
A6K30_RS04365	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6K30_RS04375	COG0582	viral genome integration into host DNA
A6K30_RS04405	COG2404	hydrolase activity, acting on ester bonds
A6K30_RS04410	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6K30_RS04415	COG1959	2 iron, 2 sulfur cluster binding
A6K30_RS04420	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6K30_RS04425	COG1196	nuclear chromosome segregation
A6K30_RS04425	COG1674	ftsk spoiiie
A6K30_RS04430	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6K30_RS04450	COG0642	Histidine kinase
A6K30_RS04460	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6K30_RS04500	COG0765	amino acid transport
A6K30_RS04525	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A6K30_RS04535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6K30_RS04550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6K30_RS04555	COG2957	Belongs to the agmatine deiminase family
A6K30_RS04565	COG0840	transmembrane signaling receptor activity
A6K30_RS04570	COG0138	bifunctional purine biosynthesis protein purh
A6K30_RS04575	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6K30_RS04580	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6K30_RS04595	COG0706	membrane insertase activity
A6K30_RS04600	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A6K30_RS04610	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6K30_RS04630	COG0824	Thioesterase
A6K30_RS04675	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6K30_RS04685	COG0681	Belongs to the peptidase S26 family
A6K30_RS04700	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A6K30_RS04730	COG0688	phosphatidylethanolamine metabolic process
A6K30_RS04735	COG1408	metallophosphoesterase
A6K30_RS04740	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6K30_RS04765	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A6K30_RS04775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6K30_RS04775	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6K30_RS04785	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6K30_RS04790	COG1049	propionate catabolic process, 2-methylcitrate cycle
A6K30_RS04800	COG4221	oxidoreductase activity
A6K30_RS04805	COG1757	Na H antiporter
A6K30_RS04825	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6K30_RS04860	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6K30_RS04865	COG1338	Plays a role in the flagellum-specific transport system
A6K30_RS04890	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A6K30_RS04895	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A6K30_RS04900	COG1663	tetraacyldisaccharide 4'-kinase activity
A6K30_RS04905	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6K30_RS04920	COG1028	Short-chain dehydrogenase reductase Sdr
A6K30_RS04930	COG0612	Peptidase, M16
A6K30_RS04935	COG0167	dihydroorotate dehydrogenase activity
A6K30_RS04940	COG1132	(ABC) transporter
A6K30_RS04945	COG0215	cysteine-tRNA ligase activity
A6K30_RS04950	COG0728	peptidoglycan biosynthetic process
A6K30_RS04960	COG0632	four-way junction helicase activity
A6K30_RS04965	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6K30_RS04985	COG0318	PFAM AMP-dependent synthetase and ligase
A6K30_RS04985	COG0204	Acyl-transferase
A6K30_RS04995	COG0788	formyltetrahydrofolate deformylase activity
A6K30_RS05000	COG0617	tRNA 3'-terminal CCA addition
A6K30_RS05025	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
A6K30_RS05045	COG3043	anaerobic respiration
A6K30_RS05050	COG0348	domain, Protein
A6K30_RS05055	COG0437	4 iron, 4 sulfur cluster binding
A6K30_RS05065	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A6K30_RS05075	COG0210	DNA helicase
A6K30_RS05090	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6K30_RS05095	COG2011	ABC-type metal ion transport system permease component
A6K30_RS05100	COG1464	Belongs to the NlpA lipoprotein family
A6K30_RS05105	COG1464	Belongs to the NlpA lipoprotein family
A6K30_RS05110	COG1464	Belongs to the NlpA lipoprotein family
A6K30_RS05120	COG0163	prenyltransferase activity
A6K30_RS05125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6K30_RS05130	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6K30_RS05140	COG1166	arginine decarboxylase activity
A6K30_RS05145	COG1045	serine acetyltransferase
A6K30_RS05150	COG0436	Aminotransferase
A6K30_RS05170	COG0443	Heat shock 70 kDa protein
A6K30_RS05175	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6K30_RS05180	COG1420	regulation of RNA biosynthetic process
A6K30_RS05185	COG4771	TonB-dependent receptor
A6K30_RS05195	COG0675	Transposase, IS605 OrfB family
A6K30_RS05245	COG3842	ATPase activity
A6K30_RS05275	COG0598	Magnesium transport protein CorA
A6K30_RS05280	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6K30_RS05290	COG0501	Belongs to the peptidase M48B family
A6K30_RS05295	COG2890	protein-(glutamine-N5) methyltransferase activity
A6K30_RS05310	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6K30_RS05315	COG0587	DNA-directed DNA polymerase activity
A6K30_RS05320	COG1393	Belongs to the ArsC family
A6K30_RS05325	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A6K30_RS05330	COG2351	hydroxyisourate hydrolase activity
A6K30_RS05335	COG0335	large ribosomal subunit rRNA binding
A6K30_RS05340	COG0336	Belongs to the RNA methyltransferase TrmD family
A6K30_RS05345	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6K30_RS05350	COG1837	Belongs to the UPF0109 family
A6K30_RS05355	COG0228	four-way junction DNA binding
A6K30_RS05360	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6K30_RS05365	COG0564	pseudouridine synthase activity
A6K30_RS05370	COG1519	Transferase
A6K30_RS05380	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6K30_RS05395	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6K30_RS05400	COG0826	peptidase U32
A6K30_RS05410	COG0174	glutamine synthetase
A6K30_RS05415	COG4786	Flagellar basal body rod
A6K30_RS05420	COG4786	Flagellar basal body rod
A6K30_RS05425	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6K30_RS05430	COG0849	cell division
A6K30_RS05435	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6K30_RS05440	COG0275	rRNA processing
A6K30_RS05455	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6K30_RS05460	COG0280	phosphate acetyltransferase
A6K30_RS05470	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A6K30_RS05475	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6K30_RS05500	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6K30_RS05505	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A6K30_RS05510	COG1137	ATPase activity
A6K30_RS05515	COG0802	atpase or kinase
A6K30_RS05520	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6K30_RS05525	COG0137	argininosuccinate synthase activity
A6K30_RS05540	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6K30_RS05545	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6K30_RS05560	COG0006	proline dipeptidase activity
A6K30_RS05595	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6K30_RS05600	COG0741	lytic transglycosylase activity
A6K30_RS05600	COG1388	LysM domain
A6K30_RS05605	COG0084	hydrolase, TatD family'
A6K30_RS05615	COG0497	DNA recombination
A6K30_RS05630	COG0563	adenylate kinase activity
A6K30_RS05635	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6K30_RS05640	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6K30_RS05655	COG0758	DNA mediated transformation
A6K30_RS05665	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6K30_RS05670	COG0557	exoribonuclease II activity
A6K30_RS05675	COG1466	dna polymerase III delta subunit
A6K30_RS05680	COG0375	protein maturation
A6K30_RS05685	COG0309	Hydrogenase expression formation protein (HypE)
A6K30_RS05690	COG0409	Hydrogenase expression formation protein
A6K30_RS05695	COG0298	carbon dioxide binding
A6K30_RS05720	COG0534	Mate efflux family protein
A6K30_RS05735	COG0581	inorganic phosphate transmembrane transporter activity
A6K30_RS05740	COG0573	inorganic phosphate transmembrane transporter activity
A6K30_RS05745	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A6K30_RS05750	COG1528	Iron-storage protein
A6K30_RS05755	COG1696	Membrane protein involved in D-alanine export
A6K30_RS05770	COG1538	Outer membrane efflux protein
A6K30_RS05775	COG1136	(ABC) transporter
A6K30_RS05775	COG0577	efflux transmembrane transporter activity
A6K30_RS05780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6K30_RS05785	COG1473	amidohydrolase
A6K30_RS05800	COG2258	MOSC domain
A6K30_RS05805	COG0733	neurotransmitter:sodium symporter activity
A6K30_RS05810	COG4773	Receptor
A6K30_RS05820	COG0745	RESPONSE REGULATOR receiver
A6K30_RS05825	COG0642	Histidine kinase
A6K30_RS05835	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A6K30_RS05840	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
A6K30_RS05845	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A6K30_RS05850	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A6K30_RS05870	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6K30_RS05875	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6K30_RS05880	COG1758	RNA polymerase activity
A6K30_RS05885	COG0528	UMP kinase activity
A6K30_RS05900	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6K30_RS05905	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6K30_RS05915	COG0564	pseudouridine synthase activity
A6K30_RS05920	COG0772	Belongs to the SEDS family
A6K30_RS05940	COG0305	Participates in initiation and elongation during chromosome replication
A6K30_RS05955	COG0492	ferredoxin-NADP+ reductase activity
A6K30_RS05960	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6K30_RS05965	COG1289	transmembrane transporter activity
A6K30_RS05970	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6K30_RS05990	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A6K30_RS06000	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A6K30_RS06005	COG0181	hydroxymethylbilane synthase activity
A6K30_RS06015	COG0442	prolyl-tRNA aminoacylation
A6K30_RS06020	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6K30_RS06025	COG0142	geranyltranstransferase activity
A6K30_RS06045	COG1013	pyruvate-flavodoxin oxidoreductase activity
A6K30_RS06050	COG0674	pyruvate-flavodoxin oxidoreductase activity
A6K30_RS06050	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A6K30_RS06060	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A6K30_RS06065	COG0045	succinate-CoA ligase (ADP-forming) activity
A6K30_RS06070	COG0039	L-malate dehydrogenase activity
A6K30_RS06095	COG1558	bacterial-type flagellum-dependent cell motility
A6K30_RS06100	COG1677	Flagellar hook-basal body complex protein FliE
A6K30_RS06105	COG0768	penicillin binding
A6K30_RS06125	COG0326	Molecular chaperone. Has ATPase activity
A6K30_RS06130	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6K30_RS06135	COG0204	Acyl-transferase
A6K30_RS06150	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6K30_RS06155	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6K30_RS06160	COG0793	Belongs to the peptidase S41A family
A6K30_RS06170	COG0542	response to heat
A6K30_RS06185	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6K30_RS06195	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6K30_RS06200	COG0673	inositol 2-dehydrogenase activity
A6K30_RS06210	COG0004	ammonium transporteR
A6K30_RS06215	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
A6K30_RS06255	COG0049	tRNA binding
A6K30_RS06260	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6K30_RS06265	COG1012	belongs to the aldehyde dehydrogenase family
A6K30_RS06270	COG3254	rhamnose metabolic process
A6K30_RS06280	COG0738	Major facilitator superfamily
A6K30_RS06285	COG1028	Short-chain dehydrogenase reductase Sdr
A6K30_RS06290	COG2271	Major facilitator Superfamily
A6K30_RS06295	COG2721	sulfolactate sulfo-lyase activity
A6K30_RS06305	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6K30_RS06325	COG0222	ribosome binding
A6K30_RS06330	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6K30_RS06335	COG0081	regulation of translation
A6K30_RS06340	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6K30_RS06345	COG0250	Participates in transcription elongation, termination and antitermination
A6K30_RS06360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6K30_RS06365	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6K30_RS06390	COG1126	abc transporter atp-binding protein
A6K30_RS06395	COG0765	amino acid transport
A6K30_RS06410	COG2346	COG2346, Truncated hemoglobins
A6K30_RS06415	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6K30_RS06420	COG0612	Peptidase, M16
A6K30_RS06425	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A6K30_RS06435	COG0195	Participates in both transcription termination and antitermination
A6K30_RS06450	COG2121	Domain of unknown function (DUF374)
A6K30_RS06470	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A6K30_RS06475	COG2176	DNA-directed DNA polymerase activity
A6K30_RS06480	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6K30_RS06485	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6K30_RS06505	COG4771	TonB-dependent receptor
A6K30_RS06510	COG2301	Belongs to the HpcH HpaI aldolase family
A6K30_RS06520	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
A6K30_RS06535	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6K30_RS06540	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6K30_RS06545	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A6K30_RS06555	COG1028	Short-chain dehydrogenase reductase Sdr
A6K30_RS06565	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6K30_RS06570	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6K30_RS06600	COG0840	transmembrane signaling receptor activity
A6K30_RS06615	COG1739	Uncharacterized protein family UPF0029
A6K30_RS06630	COG0488	(ABC) transporter
A6K30_RS06685	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6K30_RS06690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6K30_RS06695	COG1053	succinate dehydrogenase
A6K30_RS06715	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6K30_RS06775	COG0579	oxidoreductase
A6K30_RS06780	COG0469	pyruvate kinase activity
A6K30_RS06805	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6K30_RS06810	COG1160	GTP binding
A6K30_RS06815	COG2076	Multidrug Resistance protein
A6K30_RS06825	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6K30_RS06830	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6K30_RS06845	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6K30_RS06855	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6K30_RS06875	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6K30_RS06880	COG0754	glutathionylspermidine amidase activity
A6K30_RS06890	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6K30_RS06905	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6K30_RS06915	COG1538	Outer membrane efflux protein
A6K30_RS06925	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6K30_RS06930	COG1981	membrane
A6K30_RS06935	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6K30_RS06960	COG0745	RESPONSE REGULATOR receiver
A6K30_RS06965	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6K30_RS06980	COG1776	CheC inhibitor of MCP methylation
A6K30_RS06980	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6K30_RS07005	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6K30_RS07005	COG0512	Glutamine amidotransferase of anthranilate synthase
A6K30_RS07015	COG0730	response to heat
A6K30_RS07020	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6K30_RS07040	COG1238	metal cluster binding
A6K30_RS07050	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6K30_RS07055	COG1360	Flagellar Motor Protein
A6K30_RS07060	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6K30_RS07065	COG0450	alkyl hydroperoxide reductase
A6K30_RS07075	COG0105	UTP biosynthetic process
A6K30_RS07085	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6K30_RS07090	COG0416	fatty acid biosynthetic process
A6K30_RS07105	COG1570	exodeoxyribonuclease VII activity
A6K30_RS07125	COG2226	methyltransferase
A6K30_RS07140	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6K30_RS07150	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6K30_RS07175	COG0019	diaminopimelate decarboxylase activity
A6K30_RS07185	COG0193	aminoacyl-tRNA hydrolase activity
A6K30_RS07200	COG2076	Multidrug Resistance protein
A6K30_RS07205	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6K30_RS07210	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6K30_RS07215	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
A6K30_RS07230	COG4106	trans-aconitate 2-methyltransferase activity
A6K30_RS07250	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
A6K30_RS07285	COG0454	-acetyltransferase
A6K30_RS07320	COG0428	transporter
A6K30_RS07340	COG0784	Response regulator, receiver
A6K30_RS07340	COG0835	chemotaxis
A6K30_RS07345	COG0784	Response regulator, receiver
A6K30_RS07345	COG0643	Histidine kinase
A6K30_RS07345	COG2198	Histidine kinase
A6K30_RS07350	COG0835	chemotaxis
A6K30_RS07360	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
A6K30_RS07370	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6K30_RS07395	COG2079	MmgE PrpD family protein
A6K30_RS07400	COG0372	Belongs to the citrate synthase family
A6K30_RS07405	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
A6K30_RS07425	COG1077	Cell shape determining protein MreB Mrl
A6K30_RS07430	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6K30_RS07435	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6K30_RS07445	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6K30_RS07450	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6K30_RS07455	COG1942	4-Oxalocrotonate Tautomerase
A6K30_RS07485	COG2264	protein methyltransferase activity
A6K30_RS07495	COG0418	dihydroorotase activity
A6K30_RS07505	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6K30_RS07510	COG2194	sulfuric ester hydrolase activity
A6K30_RS07515	COG0708	Exodeoxyribonuclease III
A6K30_RS07525	COG2921	Belongs to the UPF0250 family
A6K30_RS07555	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6K30_RS07560	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6K30_RS07580	COG0668	transmembrane transport
A6K30_RS07585	COG0288	reversible hydration of carbon dioxide
A6K30_RS07590	COG0670	Belongs to the BI1 family
A6K30_RS07595	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6K30_RS07615	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6K30_RS07625	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6K30_RS07630	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6K30_RS07635	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6K30_RS07640	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6K30_RS07660	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6K30_RS07670	COG1968	undecaprenyl-diphosphatase activity
A6K30_RS07680	COG4953	penicillin-binding protein 1C
A6K30_RS07700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6K30_RS07700	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A6K30_RS07710	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6K30_RS07745	COG0492	ferredoxin-NADP+ reductase activity
A6K30_RS07750	COG3118	belongs to the thioredoxin family
A6K30_RS07760	COG0460	homoserine dehydrogenase
A6K30_RS07765	COG0436	Aminotransferase
A6K30_RS07790	COG0254	rRNA binding
A6K30_RS07815	COG0602	queuosine metabolic process
A6K30_RS07820	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6K30_RS07845	COG1971	Probably functions as a manganese efflux pump
A6K30_RS07865	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6K30_RS07900	COG4206	TonB-dependent receptor
A6K30_RS07900	COG1629	transport
A6K30_RS07905	COG0811	peptide transport
A6K30_RS07910	COG0848	biopolymer transport protein
A6K30_RS07920	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
A6K30_RS07930	COG1253	flavin adenine dinucleotide binding
A6K30_RS07940	COG2824	Alkylphosphonate utilization operon protein PhnA
A6K30_RS07945	COG0861	Integral membrane protein TerC family
A6K30_RS07960	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6K30_RS07965	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6K30_RS07965	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A6K30_RS07975	COG0606	chelatase, subunit chli
A6K30_RS07980	COG0242	peptide deformylase activity
A6K30_RS07995	COG0302	gtp cyclohydrolase
A6K30_RS08000	COG1157	protein secretion by the type III secretion system
A6K30_RS08015	COG1121	(ABC) transporter
A6K30_RS08020	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6K30_RS08040	COG0779	Required for maturation of 30S ribosomal subunits
A6K30_RS08060	COG0083	homoserine kinase activity
A6K30_RS08085	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6K30_RS08090	COG0483	inositol monophosphate 1-phosphatase activity
A6K30_RS08095	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6K30_RS08105	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6K30_RS08115	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6K30_RS08145	COG0037	tRNA processing
A6K30_RS08150	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6K30_RS08155	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6K30_RS08160	COG1047	Peptidyl-prolyl cis-trans
A6K30_RS08185	COG0848	biopolymer transport protein
A6K30_RS08190	COG0811	peptide transport
A6K30_RS08195	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6K30_RS08200	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6K30_RS08215	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6K30_RS08220	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6K30_RS08230	COG1475	DNA binding
A6K30_RS08235	COG1192	Involved in chromosome partitioning
A6K30_RS08240	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6K30_RS08240	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6K30_RS08290	COG1793	dna ligase
A6K30_RS08305	COG0148	phosphopyruvate hydratase activity
A6K30_RS08310	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6K30_RS08315	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A6K30_RS08320	COG1987	bacterial-type flagellum assembly
A6K30_RS08335	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6K30_RS08340	COG0372	Belongs to the citrate synthase family
A6K30_RS08355	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6K30_RS08365	COG0201	protein transport
A6K30_RS08370	COG0200	Binds to the 23S rRNA
A6K30_RS08375	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6K30_RS08380	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6K30_RS08385	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6K30_RS08390	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6K30_RS08395	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6K30_RS08400	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6K30_RS08405	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6K30_RS08410	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6K30_RS08415	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6K30_RS08420	COG0255	Belongs to the universal ribosomal protein uL29 family
A6K30_RS08425	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6K30_RS08430	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6K30_RS08435	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6K30_RS08440	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6K30_RS08450	COG0089	rRNA binding
A6K30_RS08460	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6K30_RS08465	COG0051	transcription antitermination factor activity, RNA binding
A6K30_RS08475	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A6K30_RS08530	COG0066	3-isopropylmalate dehydratase activity
A6K30_RS08540	COG0473	3-isopropylmalate dehydrogenase activity
A6K30_RS08565	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6K30_RS08570	COG0492	ferredoxin-NADP+ reductase activity
A6K30_RS08575	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A6K30_RS08580	COG0425	Belongs to the sulfur carrier protein TusA family
A6K30_RS08585	COG2391	methyltransferase activity
A6K30_RS08600	COG1749	Flagellar hook protein flgE