locus-tag	class	description
DSM104627_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
DSM104627_RS00010	COG0592	DNA-directed DNA polymerase activity
DSM104627_RS00015	COG0187	DNA topoisomerase II activity
DSM104627_RS00035	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DSM104627_RS00040	COG3162	membrane
DSM104627_RS00045	COG2056	Na+-H+ antiporter family
DSM104627_RS00050	COG0069	glutamate synthase activity
DSM104627_RS00050	COG0070	glutamate synthase
DSM104627_RS00050	COG0067	glutamate synthase
DSM104627_RS00055	COG0493	'glutamate synthase
DSM104627_RS00065	COG1592	Rubrerythrin
DSM104627_RS00080	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
DSM104627_RS00095	COG0179	Fumarylacetoacetate (FAA) hydrolase
DSM104627_RS00100	COG0564	pseudouridine synthase activity
DSM104627_RS00105	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
DSM104627_RS00110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DSM104627_RS00115	COG1823	symporter activity
DSM104627_RS00130	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
DSM104627_RS00135	COG0252	asparaginase activity
DSM104627_RS00195	COG2814	Major facilitator Superfamily
DSM104627_RS00210	COG1217	gtp-binding protein TYPA
DSM104627_RS00225	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
DSM104627_RS00250	COG0471	metal ion transport
DSM104627_RS00260	COG1611	Belongs to the LOG family
DSM104627_RS00285	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DSM104627_RS00285	COG1776	CheC inhibitor of MCP methylation
DSM104627_RS00290	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DSM104627_RS00295	COG1191	sigma factor activity
DSM104627_RS00305	COG0455	bacterial-type flagellum organization
DSM104627_RS00310	COG1419	protein localization to endoplasmic reticulum
DSM104627_RS00315	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
DSM104627_RS00320	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
DSM104627_RS00325	COG0402	S-adenosylhomocysteine deaminase activity
DSM104627_RS00330	COG0616	signal peptide processing
DSM104627_RS00345	COG2703	oxygen carrier activity
DSM104627_RS00350	COG2703	oxygen carrier activity
DSM104627_RS00360	COG1139	Iron-sulfur cluster binding protein
DSM104627_RS00365	COG0247	lactate metabolic process
DSM104627_RS00370	COG1620	l-lactate permease
DSM104627_RS00380	COG1271	oxidase subunit
DSM104627_RS00385	COG1294	oxidase, subunit
DSM104627_RS00400	COG1794	racemase activity, acting on amino acids and derivatives
DSM104627_RS00405	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
DSM104627_RS00410	COG1027	Aspartate ammonia-lyase
DSM104627_RS00415	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DSM104627_RS00435	COG0261	This protein binds to 23S rRNA in the presence of protein L20
DSM104627_RS00440	COG0211	Belongs to the bacterial ribosomal protein bL27 family
DSM104627_RS00460	COG0577	efflux transmembrane transporter activity
DSM104627_RS00460	COG1136	(ABC) transporter
DSM104627_RS00485	COG0672	)-iron permease
DSM104627_RS00495	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DSM104627_RS00500	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
DSM104627_RS00505	COG0791	NLP P60 protein
DSM104627_RS00510	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
DSM104627_RS00515	COG0024	Methionine aminopeptidase
DSM104627_RS00530	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
DSM104627_RS00530	COG3218	ABC-type transport auxiliary lipoprotein component
DSM104627_RS00535	COG1127	ABC transporter
DSM104627_RS00540	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
DSM104627_RS00545	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
DSM104627_RS00560	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
DSM104627_RS00565	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
DSM104627_RS00580	COG0358	DNA primase activity
DSM104627_RS00590	COG0328	RNA-DNA hybrid ribonuclease activity
DSM104627_RS00660	COG0848	biopolymer transport protein
DSM104627_RS00665	COG0811	peptide transport
DSM104627_RS00680	COG0814	amino acid
DSM104627_RS00685	COG1760	l-serine dehydratase
DSM104627_RS00695	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DSM104627_RS00695	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
DSM104627_RS00760	COG1194	a g-specific adenine glycosylase
DSM104627_RS00765	COG0477	Major facilitator Superfamily
DSM104627_RS00775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
DSM104627_RS00780	COG1120	ATPase activity
DSM104627_RS00785	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSM104627_RS00790	COG4771	TonB-dependent receptor
DSM104627_RS00795	COG0748	coenzyme F420 binding
DSM104627_RS00800	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
DSM104627_RS00805	COG0268	Binds directly to 16S ribosomal RNA
DSM104627_RS00810	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
DSM104627_RS00815	COG2046	Belongs to the sulfate adenylyltransferase family
DSM104627_RS00830	COG0489	protein tyrosine kinase activity
DSM104627_RS00835	COG2171	N-acyltransferase activity
DSM104627_RS00845	COG0140	phosphoribosyl-ATP diphosphatase activity
DSM104627_RS00845	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
DSM104627_RS00865	COG0131	Imidazoleglycerol-phosphate dehydratase
DSM104627_RS00865	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DSM104627_RS00875	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
DSM104627_RS00880	COG0203	ribosomal protein L17
DSM104627_RS00885	COG0202	RNA polymerase activity
DSM104627_RS00895	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
DSM104627_RS00905	COG0257	Belongs to the bacterial ribosomal protein bL36 family
DSM104627_RS00910	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
DSM104627_RS00965	COG4615	Cyclic peptide transporter
DSM104627_RS00980	COG0277	FAD linked oxidase domain protein
DSM104627_RS00990	COG0601	transmembrane transport
DSM104627_RS00995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
DSM104627_RS01000	COG4172	Belongs to the ABC transporter superfamily
DSM104627_RS01010	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM104627_RS01020	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM104627_RS01055	COG0839	Belongs to the complex I subunit 6 family
DSM104627_RS01065	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
DSM104627_RS01070	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
DSM104627_RS01120	COG2249	NAD(P)H dehydrogenase (quinone) activity
DSM104627_RS01130	COG3545	Serine hydrolase
DSM104627_RS01150	COG1204	response to ionizing radiation
DSM104627_RS01165	COG1064	alcohol dehydrogenase
DSM104627_RS01180	COG2249	NAD(P)H dehydrogenase (quinone) activity
DSM104627_RS01195	COG1984	allophanate hydrolase subunit 2
DSM104627_RS01200	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
DSM104627_RS01205	COG1914	H( )-stimulated, divalent metal cation uptake system
DSM104627_RS01215	COG2998	abc-type tungstate transport system, permease component
DSM104627_RS01220	COG4662	Binding-protein-dependent transport system inner membrane component
DSM104627_RS01225	COG3839	Belongs to the ABC transporter superfamily
DSM104627_RS01240	COG0166	Belongs to the GPI family
DSM104627_RS01245	COG0783	Belongs to the Dps family
DSM104627_RS01260	COG2992	FlgJ-related protein
DSM104627_RS01265	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
DSM104627_RS01270	COG0237	dephospho-CoA kinase activity
DSM104627_RS01275	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
DSM104627_RS01300	COG0303	'Molybdopterin
DSM104627_RS01305	COG0314	molybdopterin synthase activity
DSM104627_RS01335	COG0243	molybdopterin cofactor binding
DSM104627_RS01345	COG0437	4 iron, 4 sulfur cluster binding
DSM104627_RS01355	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
DSM104627_RS01385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
DSM104627_RS01390	COG0425	Belongs to the sulfur carrier protein TusA family
DSM104627_RS01405	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
DSM104627_RS01425	COG0505	Belongs to the CarA family
DSM104627_RS01440	COG0745	RESPONSE REGULATOR receiver
DSM104627_RS01445	COG3278	Belongs to the heme-copper respiratory oxidase family
DSM104627_RS01485	COG2887	Belongs to the helicase family. UvrD subfamily
DSM104627_RS01490	COG1074	ATP-dependent DNA helicase activity
DSM104627_RS01505	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
DSM104627_RS01510	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
DSM104627_RS01520	COG0546	phosphoglycolate phosphatase activity
DSM104627_RS01555	COG1459	type II secretion system
DSM104627_RS01560	COG0730	response to heat
DSM104627_RS01585	COG3951	Flagellar rod assembly protein muramidase FlgJ
DSM104627_RS01590	COG1706	bacterial-type flagellum-dependent cell motility
DSM104627_RS01610	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
DSM104627_RS01630	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DSM104627_RS01680	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
DSM104627_RS01680	COG0517	IMP dehydrogenase activity
DSM104627_RS01690	COG1215	transferase activity, transferring glycosyl groups
DSM104627_RS01690	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DSM104627_RS01695	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
DSM104627_RS01695	COG1215	transferase activity, transferring glycosyl groups
DSM104627_RS01715	COG0572	uridine kinase
DSM104627_RS01745	COG2124	cytochrome p450
DSM104627_RS01755	COG0736	holo-[acyl-carrier-protein] synthase activity
DSM104627_RS01760	COG1580	Controls the rotational direction of flagella during chemotaxis
DSM104627_RS01780	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
DSM104627_RS01790	COG0126	phosphoglycerate kinase activity
DSM104627_RS01800	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
DSM104627_RS01805	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
DSM104627_RS01810	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
DSM104627_RS01815	COG1918	ferrous iron import across plasma membrane
DSM104627_RS01835	COG3069	C4-dicarboxylate transmembrane transporter activity
DSM104627_RS01840	COG0251	oxidation-reduction process
DSM104627_RS01845	COG2964	Protein conserved in bacteria
DSM104627_RS01855	COG0753	catalase activity
DSM104627_RS01870	COG0716	FMN binding
DSM104627_RS01890	COG3276	selenocysteine insertion sequence binding
DSM104627_RS01905	COG2814	Major facilitator Superfamily
DSM104627_RS01930	COG2853	Lipoprotein
DSM104627_RS01940	COG2252	PERMEase
DSM104627_RS01945	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DSM104627_RS01955	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
DSM104627_RS01960	COG0114	fumarate hydratase activity
DSM104627_RS01965	COG0628	permease
DSM104627_RS01990	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
DSM104627_RS02000	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
DSM104627_RS02015	COG4607	ABC-type enterochelin transport system periplasmic component
DSM104627_RS02020	COG4604	ABC transporter, ATP-binding protein
DSM104627_RS02025	COG4605	iron ion homeostasis
DSM104627_RS02030	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
DSM104627_RS02055	COG0575	Belongs to the CDS family
DSM104627_RS02075	COG2165	general secretion pathway protein
DSM104627_RS02095	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DSM104627_RS02115	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104627_RS02120	COG1083	cytidylyl-transferase
DSM104627_RS02130	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DSM104627_RS02135	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
DSM104627_RS02140	COG2089	acid synthase
DSM104627_RS02155	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DSM104627_RS02160	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM104627_RS02165	COG2089	acid synthase
DSM104627_RS02180	COG0107	imidazoleglycerol-phosphate synthase activity
DSM104627_RS02185	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
DSM104627_RS02190	COG3980	spore coat polysaccharide biosynthesis protein
DSM104627_RS02195	COG1083	cytidylyl-transferase
DSM104627_RS02205	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DSM104627_RS02220	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
DSM104627_RS02250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DSM104627_RS02285	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DSM104627_RS02290	COG1086	Polysaccharide biosynthesis protein
DSM104627_RS02300	COG0511	ligase activity, forming carbon-carbon bonds
DSM104627_RS02305	COG0439	Biotin carboxylase
DSM104627_RS02310	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DSM104627_RS02315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM104627_RS02320	COG0281	malic enzyme
DSM104627_RS02320	COG0280	phosphate acetyltransferase
DSM104627_RS02325	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
DSM104627_RS02330	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DSM104627_RS02335	COG0569	domain protein
DSM104627_RS02340	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
DSM104627_RS02360	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DSM104627_RS02360	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DSM104627_RS02370	COG0028	Belongs to the TPP enzyme family
DSM104627_RS02375	COG0440	acetolactate synthase activity
DSM104627_RS02390	COG0805	protein transport
DSM104627_RS02400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DSM104627_RS02405	COG0494	nUDIX hydrolase
DSM104627_RS02410	COG0527	aspartate kinase activity
DSM104627_RS02425	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
DSM104627_RS02430	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
DSM104627_RS02450	COG2890	protein-(glutamine-N5) methyltransferase activity
DSM104627_RS02460	COG2860	membrane
DSM104627_RS02470	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
DSM104627_RS02475	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DSM104627_RS02480	COG0191	fructose-bisphosphate aldolase activity
DSM104627_RS02500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
DSM104627_RS02515	COG1942	4-Oxalocrotonate Tautomerase
DSM104627_RS02525	COG1185	polyribonucleotide nucleotidyltransferase activity
DSM104627_RS02550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DSM104627_RS02555	COG2226	methyltransferase
DSM104627_RS02580	COG0731	radical SAM domain protein
DSM104627_RS02600	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
DSM104627_RS02625	COG0739	heme binding
DSM104627_RS02630	COG0751	glycine-tRNA ligase activity
DSM104627_RS02645	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
DSM104627_RS02645	COG0475	glutathione-regulated potassium exporter activity
DSM104627_RS02650	COG0789	Transcriptional regulator
DSM104627_RS02655	COG0484	heat shock protein binding
DSM104627_RS02660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
DSM104627_RS02665	COG0745	RESPONSE REGULATOR receiver
DSM104627_RS02670	COG0642	Histidine kinase
DSM104627_RS02715	COG2703	oxygen carrier activity
DSM104627_RS02720	COG0745	RESPONSE REGULATOR receiver
DSM104627_RS02725	COG0642	Histidine kinase
DSM104627_RS02745	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
DSM104627_RS02760	COG1496	oxidoreductase activity
DSM104627_RS02770	COG0739	heme binding
DSM104627_RS02785	COG1295	ribonuclease BN
DSM104627_RS02815	COG0552	protein localization to endoplasmic reticulum
DSM104627_RS02820	COG0523	cobalamin synthesis protein
DSM104627_RS02840	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
DSM104627_RS02855	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
DSM104627_RS02890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
DSM104627_RS02905	COG1301	dicarboxylic acid transport
DSM104627_RS02930	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
DSM104627_RS02935	COG0723	plastoquinol--plastocyanin reductase activity
DSM104627_RS02940	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
DSM104627_RS02950	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
DSM104627_RS02955	COG0052	Belongs to the universal ribosomal protein uS2 family
DSM104627_RS02965	COG1136	(ABC) transporter
DSM104627_RS02980	COG0194	GDP metabolic process
DSM104627_RS02985	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
DSM104627_RS02990	COG0018	arginyl-trna synthetase
DSM104627_RS03000	COG2076	Multidrug Resistance protein
DSM104627_RS03005	COG0217	transcriptional regulatory protein
DSM104627_RS03010	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
DSM104627_RS03025	COG0586	Pfam SNARE associated Golgi protein
DSM104627_RS03030	COG0039	L-malate dehydrogenase activity
DSM104627_RS03040	COG3610	response to peptide
DSM104627_RS03060	COG2217	Heavy metal translocating P-type atpase
DSM104627_RS03065	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
DSM104627_RS03070	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
DSM104627_RS03075	COG2217	Heavy metal translocating P-type atpase
DSM104627_RS03090	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
DSM104627_RS03095	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
DSM104627_RS03120	COG1216	Glycosyl transferase, family 2
DSM104627_RS03130	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
DSM104627_RS03155	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
DSM104627_RS03165	COG0028	Belongs to the TPP enzyme family
DSM104627_RS03205	COG0859	PFAM glycosyl transferase family 9
DSM104627_RS03215	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
DSM104627_RS03220	COG1132	(ABC) transporter
DSM104627_RS03225	COG0438	transferase activity, transferring glycosyl groups
DSM104627_RS03230	COG1215	transferase activity, transferring glycosyl groups
DSM104627_RS03235	COG0438	transferase activity, transferring glycosyl groups
DSM104627_RS03245	COG0438	transferase activity, transferring glycosyl groups
DSM104627_RS03250	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
DSM104627_RS03255	COG0110	maltose O-acetyltransferase activity
DSM104627_RS03260	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
DSM104627_RS03265	COG1086	Polysaccharide biosynthesis protein
DSM104627_RS03270	COG0745	RESPONSE REGULATOR receiver
DSM104627_RS03280	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSM104627_RS03290	COG1183	phosphatidylcholine synthase activity
DSM104627_RS03295	COG2833	Protein of unknown function (DUF455)
DSM104627_RS03300	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM104627_RS03305	COG2095	MarC family integral membrane protein
DSM104627_RS03310	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
DSM104627_RS03315	COG0542	response to heat
DSM104627_RS03325	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
DSM104627_RS03330	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
DSM104627_RS03370	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
DSM104627_RS03375	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
DSM104627_RS03395	COG0815	Transfers the fatty acyl group on membrane lipoproteins
DSM104627_RS03400	COG1862	Preprotein translocase
DSM104627_RS03405	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DSM104627_RS03410	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
DSM104627_RS03435	COG0739	heme binding
DSM104627_RS03445	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
DSM104627_RS03465	COG0352	thiamine-phosphate diphosphorylase activity
DSM104627_RS03490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
DSM104627_RS03495	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
DSM104627_RS03505	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
DSM104627_RS03510	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
DSM104627_RS03515	COG0629	single-stranded DNA binding
DSM104627_RS03520	COG0360	Binds together with S18 to 16S ribosomal RNA
DSM104627_RS03525	COG2271	Major facilitator Superfamily
DSM104627_RS03540	COG0750	zinc metalloprotease
DSM104627_RS03545	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
DSM104627_RS03550	COG0778	Nitroreductase
DSM104627_RS03555	COG0778	Nitroreductase
DSM104627_RS03565	COG1058	Belongs to the CinA family
DSM104627_RS03565	COG1546	Belongs to the CinA family
DSM104627_RS03570	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
DSM104627_RS03575	COG0154	amidase activity
DSM104627_RS03580	COG0516	GMP reductase activity
DSM104627_RS03580	COG0517	IMP dehydrogenase activity
DSM104627_RS03630	COG1193	negative regulation of DNA recombination
DSM104627_RS03680	COG0352	thiamine-phosphate diphosphorylase activity
DSM104627_RS03705	COG0772	Belongs to the SEDS family
DSM104627_RS03710	COG0439	Biotin carboxylase
DSM104627_RS03745	COG0481	GTPase activity
DSM104627_RS03760	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
DSM104627_RS03775	COG2204	response regulator
DSM104627_RS03780	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
DSM104627_RS03790	COG4773	Receptor
DSM104627_RS03830	COG1333	cytochrome c biogenesis protein
DSM104627_RS03830	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
DSM104627_RS03870	COG0343	queuine tRNA-ribosyltransferase activity
DSM104627_RS03890	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
DSM104627_RS03895	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSM104627_RS03915	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
DSM104627_RS03920	COG0583	DNA-binding transcription factor activity
DSM104627_RS03925	COG2855	membrane
DSM104627_RS03935	COG0357	Ribosomal RNA small subunit methyltransferase G
DSM104627_RS03940	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
DSM104627_RS03945	COG0113	porphobilinogen synthase activity
DSM104627_RS03950	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
DSM104627_RS03960	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DSM104627_RS03965	COG0247	lactate metabolic process
DSM104627_RS03965	COG2181	nitrate reductase activity
DSM104627_RS03980	COG3022	response to hydroperoxide
DSM104627_RS03990	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM104627_RS03995	COG0477	Major facilitator Superfamily
DSM104627_RS04000	COG2195	Cleaves the N-terminal amino acid of tripeptides
DSM104627_RS04005	COG1525	nuclease
DSM104627_RS04045	COG0733	neurotransmitter:sodium symporter activity
DSM104627_RS04050	COG0733	neurotransmitter:sodium symporter activity
DSM104627_RS04070	COG0012	GTP binding
DSM104627_RS04075	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
DSM104627_RS04085	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
DSM104627_RS04100	COG2201	protein-glutamate methylesterase activity
DSM104627_RS04105	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
DSM104627_RS04110	COG1126	abc transporter atp-binding protein
DSM104627_RS04115	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
DSM104627_RS04120	COG0765	amino acid transport
DSM104627_RS04125	COG0765	amino acid transport
DSM104627_RS04130	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
DSM104627_RS04135	COG1966	Carbon starvation protein
DSM104627_RS04140	COG2879	small protein
DSM104627_RS04155	COG0776	regulation of translation
DSM104627_RS04160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
DSM104627_RS04165	COG1999	signal sequence binding
DSM104627_RS04190	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
DSM104627_RS04195	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
DSM104627_RS04200	COG1115	amino acid carrier protein
DSM104627_RS04205	COG1126	abc transporter atp-binding protein
DSM104627_RS04210	COG0765	amino acid transport
DSM104627_RS04225	COG0537	adenosine 5'-monophosphoramidase activity
DSM104627_RS04230	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
DSM104627_RS04250	COG0539	negative regulation of cytoplasmic translation
DSM104627_RS04250	COG1185	polyribonucleotide nucleotidyltransferase activity
DSM104627_RS04260	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
DSM104627_RS04265	COG0745	RESPONSE REGULATOR receiver
DSM104627_RS04270	COG2205	protein histidine kinase activity
DSM104627_RS04270	COG2202	Pas domain
DSM104627_RS04275	COG0488	(ABC) transporter
DSM104627_RS04285	COG0303	'Molybdopterin
DSM104627_RS04300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DSM104627_RS04300	COG0512	Glutamine amidotransferase of anthranilate synthase
DSM104627_RS04310	COG0582	viral genome integration into host DNA
DSM104627_RS04340	COG2404	hydrolase activity, acting on ester bonds
DSM104627_RS04345	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DSM104627_RS04350	COG1959	2 iron, 2 sulfur cluster binding
DSM104627_RS04355	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
DSM104627_RS04360	COG1674	ftsk spoiiie
DSM104627_RS04360	COG1196	nuclear chromosome segregation
DSM104627_RS04365	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
DSM104627_RS04380	COG0642	Histidine kinase
DSM104627_RS04390	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
DSM104627_RS04430	COG0765	amino acid transport
DSM104627_RS04455	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
DSM104627_RS04465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
DSM104627_RS04480	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
DSM104627_RS04485	COG2957	Belongs to the agmatine deiminase family
DSM104627_RS04495	COG0840	transmembrane signaling receptor activity
DSM104627_RS04500	COG0138	bifunctional purine biosynthesis protein purh
DSM104627_RS04505	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
DSM104627_RS04510	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DSM104627_RS04525	COG0706	membrane insertase activity
DSM104627_RS04530	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
DSM104627_RS04540	COG0230	Belongs to the bacterial ribosomal protein bL34 family
DSM104627_RS04560	COG0824	Thioesterase
DSM104627_RS04595	COG0803	Belongs to the bacterial solute-binding protein 9 family
DSM104627_RS04605	COG0681	Belongs to the peptidase S26 family
DSM104627_RS04620	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
DSM104627_RS04650	COG0688	phosphatidylethanolamine metabolic process
DSM104627_RS04655	COG1408	metallophosphoesterase
DSM104627_RS04660	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
DSM104627_RS04685	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
DSM104627_RS04695	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM104627_RS04695	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
DSM104627_RS04705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
DSM104627_RS04710	COG1049	propionate catabolic process, 2-methylcitrate cycle
DSM104627_RS04720	COG4221	oxidoreductase activity
DSM104627_RS04725	COG1757	Na H antiporter
DSM104627_RS04745	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
DSM104627_RS04750	COG0101	tRNA pseudouridine synthase activity
DSM104627_RS04780	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
DSM104627_RS04785	COG1338	Plays a role in the flagellum-specific transport system
DSM104627_RS04810	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
DSM104627_RS04815	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
DSM104627_RS04820	COG1663	tetraacyldisaccharide 4'-kinase activity
DSM104627_RS04825	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
DSM104627_RS04840	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104627_RS04850	COG0612	Peptidase, M16
DSM104627_RS04855	COG0167	dihydroorotate dehydrogenase activity
DSM104627_RS04860	COG1132	(ABC) transporter
DSM104627_RS04865	COG0215	cysteine-tRNA ligase activity
DSM104627_RS04870	COG0728	peptidoglycan biosynthetic process
DSM104627_RS04880	COG0632	four-way junction helicase activity
DSM104627_RS04885	COG1181	Belongs to the D-alanine--D-alanine ligase family
DSM104627_RS04905	COG0318	PFAM AMP-dependent synthetase and ligase
DSM104627_RS04905	COG0204	Acyl-transferase
DSM104627_RS04915	COG0788	formyltetrahydrofolate deformylase activity
DSM104627_RS04920	COG0617	tRNA 3'-terminal CCA addition
DSM104627_RS04945	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
DSM104627_RS04965	COG3043	anaerobic respiration
DSM104627_RS04970	COG0348	domain, Protein
DSM104627_RS04975	COG0437	4 iron, 4 sulfur cluster binding
DSM104627_RS04985	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
DSM104627_RS04995	COG0210	DNA helicase
DSM104627_RS05010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DSM104627_RS05015	COG2011	ABC-type metal ion transport system permease component
DSM104627_RS05020	COG1464	Belongs to the NlpA lipoprotein family
DSM104627_RS05025	COG1464	Belongs to the NlpA lipoprotein family
DSM104627_RS05030	COG1464	Belongs to the NlpA lipoprotein family
DSM104627_RS05040	COG0163	prenyltransferase activity
DSM104627_RS05045	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
DSM104627_RS05050	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
DSM104627_RS05060	COG1166	arginine decarboxylase activity
DSM104627_RS05065	COG1045	serine acetyltransferase
DSM104627_RS05070	COG0436	Aminotransferase
DSM104627_RS05090	COG0443	Heat shock 70 kDa protein
DSM104627_RS05095	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
DSM104627_RS05100	COG1420	regulation of RNA biosynthetic process
DSM104627_RS05105	COG4771	TonB-dependent receptor
DSM104627_RS05115	COG0675	Transposase, IS605 OrfB family
DSM104627_RS05160	COG3842	ATPase activity
DSM104627_RS05190	COG0598	Magnesium transport protein CorA
DSM104627_RS05195	COG0521	Mo-molybdopterin cofactor biosynthetic process
DSM104627_RS05205	COG0501	Belongs to the peptidase M48B family
DSM104627_RS05210	COG2890	protein-(glutamine-N5) methyltransferase activity
DSM104627_RS05225	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
DSM104627_RS05230	COG0587	DNA-directed DNA polymerase activity
DSM104627_RS05235	COG1393	Belongs to the ArsC family
DSM104627_RS05240	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
DSM104627_RS05245	COG2351	hydroxyisourate hydrolase activity
DSM104627_RS05250	COG0335	large ribosomal subunit rRNA binding
DSM104627_RS05255	COG0336	Belongs to the RNA methyltransferase TrmD family
DSM104627_RS05260	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
DSM104627_RS05265	COG1837	Belongs to the UPF0109 family
DSM104627_RS05270	COG0228	four-way junction DNA binding
DSM104627_RS05275	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
DSM104627_RS05280	COG0564	pseudouridine synthase activity
DSM104627_RS05285	COG1519	Transferase
DSM104627_RS05295	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
DSM104627_RS05310	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
DSM104627_RS05315	COG0826	peptidase U32
DSM104627_RS05325	COG0174	glutamine synthetase
DSM104627_RS05330	COG4786	Flagellar basal body rod
DSM104627_RS05335	COG4786	Flagellar basal body rod
DSM104627_RS05340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
DSM104627_RS05345	COG0849	cell division
DSM104627_RS05350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
DSM104627_RS05355	COG0275	rRNA processing
DSM104627_RS05370	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
DSM104627_RS05375	COG0280	phosphate acetyltransferase
DSM104627_RS05385	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
DSM104627_RS05390	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
DSM104627_RS05415	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
DSM104627_RS05420	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
DSM104627_RS05425	COG1137	ATPase activity
DSM104627_RS05430	COG0802	atpase or kinase
DSM104627_RS05435	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
DSM104627_RS05440	COG0137	argininosuccinate synthase activity
DSM104627_RS05455	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
DSM104627_RS05460	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
DSM104627_RS05510	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
DSM104627_RS05515	COG0741	lytic transglycosylase activity
DSM104627_RS05515	COG1388	LysM domain
DSM104627_RS05520	COG0084	hydrolase, TatD family'
DSM104627_RS05530	COG0497	DNA recombination
DSM104627_RS05545	COG0563	adenylate kinase activity
DSM104627_RS05550	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
DSM104627_RS05555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
DSM104627_RS05570	COG0758	DNA mediated transformation
DSM104627_RS05580	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
DSM104627_RS05585	COG0557	exoribonuclease II activity
DSM104627_RS05590	COG1466	dna polymerase III delta subunit
DSM104627_RS05595	COG0375	protein maturation
DSM104627_RS05600	COG0309	Hydrogenase expression formation protein (HypE)
DSM104627_RS05605	COG0409	Hydrogenase expression formation protein
DSM104627_RS05610	COG0298	carbon dioxide binding
DSM104627_RS05620	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
DSM104627_RS05635	COG0534	Mate efflux family protein
DSM104627_RS05650	COG0581	inorganic phosphate transmembrane transporter activity
DSM104627_RS05655	COG0573	inorganic phosphate transmembrane transporter activity
DSM104627_RS05660	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
DSM104627_RS05665	COG1528	Iron-storage protein
DSM104627_RS05670	COG1696	Membrane protein involved in D-alanine export
DSM104627_RS05685	COG1538	Outer membrane efflux protein
DSM104627_RS05690	COG0577	efflux transmembrane transporter activity
DSM104627_RS05690	COG1136	(ABC) transporter
DSM104627_RS05695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM104627_RS05700	COG1473	amidohydrolase
DSM104627_RS05715	COG2258	MOSC domain
DSM104627_RS05720	COG0733	neurotransmitter:sodium symporter activity
DSM104627_RS05725	COG4773	Receptor
DSM104627_RS05735	COG0745	RESPONSE REGULATOR receiver
DSM104627_RS05740	COG0642	Histidine kinase
DSM104627_RS05750	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
DSM104627_RS05755	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
DSM104627_RS05760	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
DSM104627_RS05765	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
DSM104627_RS05785	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
DSM104627_RS05790	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
DSM104627_RS05795	COG1758	RNA polymerase activity
DSM104627_RS05800	COG0528	UMP kinase activity
DSM104627_RS05815	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
DSM104627_RS05820	COG0220	tRNA (guanine-N7-)-methyltransferase activity
DSM104627_RS05830	COG0564	pseudouridine synthase activity
DSM104627_RS05835	COG0772	Belongs to the SEDS family
DSM104627_RS05850	COG0305	Participates in initiation and elongation during chromosome replication
DSM104627_RS05865	COG0492	ferredoxin-NADP+ reductase activity
DSM104627_RS05870	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
DSM104627_RS05875	COG1289	transmembrane transporter activity
DSM104627_RS05880	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
DSM104627_RS05900	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
DSM104627_RS05910	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
DSM104627_RS05915	COG0181	hydroxymethylbilane synthase activity
DSM104627_RS05925	COG0442	prolyl-tRNA aminoacylation
DSM104627_RS05930	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
DSM104627_RS05935	COG0142	geranyltranstransferase activity
DSM104627_RS05955	COG1013	pyruvate-flavodoxin oxidoreductase activity
DSM104627_RS05960	COG0674	pyruvate-flavodoxin oxidoreductase activity
DSM104627_RS05960	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
DSM104627_RS05970	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
DSM104627_RS05975	COG0045	succinate-CoA ligase (ADP-forming) activity
DSM104627_RS05980	COG0039	L-malate dehydrogenase activity
DSM104627_RS06000	COG1815	bacterial-type flagellum-dependent cell motility
DSM104627_RS06005	COG1558	bacterial-type flagellum-dependent cell motility
DSM104627_RS06010	COG1677	Flagellar hook-basal body complex protein FliE
DSM104627_RS06015	COG0768	penicillin binding
DSM104627_RS06035	COG0326	Molecular chaperone. Has ATPase activity
DSM104627_RS06040	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
DSM104627_RS06045	COG0204	Acyl-transferase
DSM104627_RS06055	COG0047	phosphoribosylformylglycinamidine synthase activity
DSM104627_RS06060	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
DSM104627_RS06065	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
DSM104627_RS06070	COG0793	Belongs to the peptidase S41A family
DSM104627_RS06080	COG0542	response to heat
DSM104627_RS06095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
DSM104627_RS06105	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
DSM104627_RS06170	COG0049	tRNA binding
DSM104627_RS06175	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
DSM104627_RS06180	COG1012	belongs to the aldehyde dehydrogenase family
DSM104627_RS06185	COG3254	rhamnose metabolic process
DSM104627_RS06195	COG0738	Major facilitator superfamily
DSM104627_RS06200	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104627_RS06205	COG2271	Major facilitator Superfamily
DSM104627_RS06210	COG2721	sulfolactate sulfo-lyase activity
DSM104627_RS06220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
DSM104627_RS06235	COG0085	RNA polymerase activity
DSM104627_RS06240	COG0222	ribosome binding
DSM104627_RS06245	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
DSM104627_RS06250	COG0081	regulation of translation
DSM104627_RS06255	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
DSM104627_RS06260	COG0250	Participates in transcription elongation, termination and antitermination
DSM104627_RS06275	COG0267	Belongs to the bacterial ribosomal protein bL33 family
DSM104627_RS06280	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
DSM104627_RS06305	COG1126	abc transporter atp-binding protein
DSM104627_RS06310	COG0765	amino acid transport
DSM104627_RS06325	COG2346	COG2346, Truncated hemoglobins
DSM104627_RS06330	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
DSM104627_RS06335	COG0612	Peptidase, M16
DSM104627_RS06340	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
DSM104627_RS06350	COG0195	Participates in both transcription termination and antitermination
DSM104627_RS06365	COG2121	Domain of unknown function (DUF374)
DSM104627_RS06385	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
DSM104627_RS06390	COG2176	DNA-directed DNA polymerase activity
DSM104627_RS06395	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
DSM104627_RS06400	COG0227	Belongs to the bacterial ribosomal protein bL28 family
DSM104627_RS06420	COG4771	TonB-dependent receptor
DSM104627_RS06450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
DSM104627_RS06455	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
DSM104627_RS06460	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
DSM104627_RS06470	COG1028	Short-chain dehydrogenase reductase Sdr
DSM104627_RS06480	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
DSM104627_RS06485	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
DSM104627_RS06515	COG0840	transmembrane signaling receptor activity
DSM104627_RS06530	COG1739	Uncharacterized protein family UPF0029
DSM104627_RS06545	COG0488	(ABC) transporter
DSM104627_RS06600	COG1132	(ABC) transporter
DSM104627_RS06605	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
DSM104627_RS06610	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
DSM104627_RS06615	COG1053	succinate dehydrogenase
DSM104627_RS06635	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
DSM104627_RS06690	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
DSM104627_RS06695	COG0579	oxidoreductase
DSM104627_RS06700	COG0469	pyruvate kinase activity
DSM104627_RS06725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
DSM104627_RS06730	COG1160	GTP binding
DSM104627_RS06735	COG2076	Multidrug Resistance protein
DSM104627_RS06745	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
DSM104627_RS06750	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
DSM104627_RS06765	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
DSM104627_RS06775	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
DSM104627_RS06795	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
DSM104627_RS06800	COG0754	glutathionylspermidine amidase activity
DSM104627_RS06810	COG0828	Belongs to the bacterial ribosomal protein bS21 family
DSM104627_RS06825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
DSM104627_RS06835	COG1538	Outer membrane efflux protein
DSM104627_RS06845	COG0635	Involved in the biosynthesis of porphyrin-containing compound
DSM104627_RS06850	COG1981	membrane
DSM104627_RS06855	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
DSM104627_RS06880	COG0745	RESPONSE REGULATOR receiver
DSM104627_RS06885	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
DSM104627_RS06900	COG1776	CheC inhibitor of MCP methylation
DSM104627_RS06900	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DSM104627_RS06925	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
DSM104627_RS06925	COG0512	Glutamine amidotransferase of anthranilate synthase
DSM104627_RS06935	COG0730	response to heat
DSM104627_RS06940	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
DSM104627_RS06960	COG1238	metal cluster binding
DSM104627_RS06970	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
DSM104627_RS06975	COG1360	Flagellar Motor Protein
DSM104627_RS06980	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
DSM104627_RS06985	COG0450	alkyl hydroperoxide reductase
DSM104627_RS06995	COG0105	UTP biosynthetic process
DSM104627_RS07005	COG0333	Belongs to the bacterial ribosomal protein bL32 family
DSM104627_RS07010	COG0416	fatty acid biosynthetic process
DSM104627_RS07015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
DSM104627_RS07025	COG1570	exodeoxyribonuclease VII activity
DSM104627_RS07045	COG2226	methyltransferase
DSM104627_RS07060	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
DSM104627_RS07070	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
DSM104627_RS07095	COG0019	diaminopimelate decarboxylase activity
DSM104627_RS07105	COG0193	aminoacyl-tRNA hydrolase activity
DSM104627_RS07120	COG2076	Multidrug Resistance protein
DSM104627_RS07125	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
DSM104627_RS07130	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
DSM104627_RS07135	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
DSM104627_RS07150	COG4106	trans-aconitate 2-methyltransferase activity
DSM104627_RS07170	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
DSM104627_RS07210	COG0454	-acetyltransferase
DSM104627_RS07245	COG0428	transporter
DSM104627_RS07265	COG0784	Response regulator, receiver
DSM104627_RS07265	COG0835	chemotaxis
DSM104627_RS07270	COG0784	Response regulator, receiver
DSM104627_RS07270	COG0643	Histidine kinase
DSM104627_RS07270	COG2198	Histidine kinase
DSM104627_RS07275	COG0835	chemotaxis
DSM104627_RS07285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
DSM104627_RS07295	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
DSM104627_RS07320	COG2079	MmgE PrpD family protein
DSM104627_RS07325	COG0372	Belongs to the citrate synthase family
DSM104627_RS07330	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
DSM104627_RS07350	COG1077	Cell shape determining protein MreB Mrl
DSM104627_RS07355	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
DSM104627_RS07360	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
DSM104627_RS07370	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
DSM104627_RS07375	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
DSM104627_RS07380	COG1942	4-Oxalocrotonate Tautomerase
DSM104627_RS07410	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
DSM104627_RS07420	COG0418	dihydroorotase activity
DSM104627_RS07430	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
DSM104627_RS07435	COG2194	sulfuric ester hydrolase activity
DSM104627_RS07440	COG0708	Exodeoxyribonuclease III
DSM104627_RS07450	COG2921	Belongs to the UPF0250 family
DSM104627_RS07480	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
DSM104627_RS07485	COG0291	Belongs to the bacterial ribosomal protein bL35 family
DSM104627_RS07505	COG0668	transmembrane transport
DSM104627_RS07510	COG0288	reversible hydration of carbon dioxide
DSM104627_RS07515	COG0670	Belongs to the BI1 family
DSM104627_RS07520	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
DSM104627_RS07540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
DSM104627_RS07550	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
DSM104627_RS07555	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
DSM104627_RS07560	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
DSM104627_RS07565	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
DSM104627_RS07585	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
DSM104627_RS07595	COG1968	undecaprenyl-diphosphatase activity
DSM104627_RS07605	COG4953	penicillin-binding protein 1C
DSM104627_RS07610	COG2373	Large extracellular alpha-helical protein
DSM104627_RS07625	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
DSM104627_RS07625	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
DSM104627_RS07635	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
DSM104627_RS07650	COG0243	molybdopterin cofactor binding
DSM104627_RS07655	COG0428	transporter
DSM104627_RS07665	COG1157	protein secretion by the type III secretion system
DSM104627_RS07670	COG0302	gtp cyclohydrolase
DSM104627_RS07685	COG0242	peptide deformylase activity
DSM104627_RS07690	COG0606	chelatase, subunit chli
DSM104627_RS07700	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
DSM104627_RS07700	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
DSM104627_RS07705	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
DSM104627_RS07720	COG0861	Integral membrane protein TerC family
DSM104627_RS07725	COG2824	Alkylphosphonate utilization operon protein PhnA
DSM104627_RS07735	COG1253	flavin adenine dinucleotide binding
DSM104627_RS07745	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
DSM104627_RS07755	COG0848	biopolymer transport protein
DSM104627_RS07760	COG0811	peptide transport
DSM104627_RS07765	COG4206	TonB-dependent receptor
DSM104627_RS07765	COG1629	transport
DSM104627_RS07780	COG1840	ABC-type Fe3 transport system, periplasmic component
DSM104627_RS07800	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
DSM104627_RS07820	COG1971	Probably functions as a manganese efflux pump
DSM104627_RS07845	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
DSM104627_RS07850	COG0602	queuosine metabolic process
DSM104627_RS07870	COG1385	rRNA (uridine-N3-)-methyltransferase activity
DSM104627_RS07875	COG0254	rRNA binding
DSM104627_RS07880	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
DSM104627_RS07900	COG0436	Aminotransferase
DSM104627_RS07905	COG0460	homoserine dehydrogenase
DSM104627_RS07915	COG3118	belongs to the thioredoxin family
DSM104627_RS07920	COG0492	ferredoxin-NADP+ reductase activity
DSM104627_RS07930	COG0840	transmembrane signaling receptor activity
DSM104627_RS07940	COG1121	(ABC) transporter
DSM104627_RS07945	COG1108	ABC-type Mn2 Zn2 transport systems permease components
DSM104627_RS07955	COG1401	restriction endodeoxyribonuclease activity
DSM104627_RS07965	COG0779	Required for maturation of 30S ribosomal subunits
DSM104627_RS07985	COG0083	homoserine kinase activity
DSM104627_RS08010	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
DSM104627_RS08015	COG0483	inositol monophosphate 1-phosphatase activity
DSM104627_RS08020	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
DSM104627_RS08030	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
DSM104627_RS08040	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
DSM104627_RS08070	COG0037	tRNA processing
DSM104627_RS08075	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
DSM104627_RS08080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
DSM104627_RS08085	COG1047	Peptidyl-prolyl cis-trans
DSM104627_RS08110	COG0848	biopolymer transport protein
DSM104627_RS08115	COG0811	peptide transport
DSM104627_RS08120	COG0355	proton-transporting ATP synthase activity, rotational mechanism
DSM104627_RS08125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
DSM104627_RS08140	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
DSM104627_RS08145	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
DSM104627_RS08155	COG1475	DNA binding
DSM104627_RS08160	COG1192	Involved in chromosome partitioning
DSM104627_RS08165	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
DSM104627_RS08165	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
DSM104627_RS08210	COG1793	dna ligase
DSM104627_RS08225	COG0148	phosphopyruvate hydratase activity
DSM104627_RS08230	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
DSM104627_RS08235	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
DSM104627_RS08240	COG1987	bacterial-type flagellum assembly
DSM104627_RS08260	COG1218	3'(2'),5'-bisphosphate nucleotidase
DSM104627_RS08265	COG0372	Belongs to the citrate synthase family
DSM104627_RS08280	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
DSM104627_RS08290	COG0201	protein transport
DSM104627_RS08295	COG0200	Binds to the 23S rRNA
DSM104627_RS08300	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
DSM104627_RS08305	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
DSM104627_RS08310	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
DSM104627_RS08315	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
DSM104627_RS08320	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
DSM104627_RS08325	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
DSM104627_RS08330	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
DSM104627_RS08335	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
DSM104627_RS08340	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
DSM104627_RS08345	COG0255	Belongs to the universal ribosomal protein uL29 family
DSM104627_RS08350	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
DSM104627_RS08355	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
DSM104627_RS08360	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
DSM104627_RS08365	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
DSM104627_RS08375	COG0089	rRNA binding
DSM104627_RS08385	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
DSM104627_RS08390	COG0051	transcription antitermination factor activity, RNA binding
DSM104627_RS08395	COG1187	pseudouridine synthase activity
DSM104627_RS08400	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
DSM104627_RS08450	COG0066	3-isopropylmalate dehydratase activity
DSM104627_RS08460	COG0473	3-isopropylmalate dehydrogenase activity
DSM104627_RS08485	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
DSM104627_RS08495	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
DSM104627_RS08500	COG0425	Belongs to the sulfur carrier protein TusA family
DSM104627_RS08505	COG2391	methyltransferase activity
DSM104627_RS08515	COG1749	Flagellar hook protein flgE