locus-tag	class	description
G5B99_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
G5B99_RS00010	COG0592	DNA-directed DNA polymerase activity
G5B99_RS00015	COG0187	DNA topoisomerase II activity
G5B99_RS00020	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
G5B99_RS00040	COG1749	Flagellar hook protein flgE
G5B99_RS00045	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
G5B99_RS00055	COG1217	gtp-binding protein TYPA
G5B99_RS00075	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
G5B99_RS00085	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
G5B99_RS00090	COG0571	ribonuclease III activity
G5B99_RS00095	COG0328	RNA-DNA hybrid ribonuclease activity
G5B99_RS00105	COG0358	DNA primase activity
G5B99_RS00110	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G5B99_RS00115	COG1473	amidohydrolase
G5B99_RS00125	COG3069	C4-dicarboxylate transmembrane transporter activity
G5B99_RS00130	COG2195	Cleaves the N-terminal amino acid of tripeptides
G5B99_RS00135	COG0137	argininosuccinate synthase activity
G5B99_RS00295	COG3875	lactate racemase activity
G5B99_RS00300	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
G5B99_RS00305	COG1606	tRNA processing
G5B99_RS00310	COG1691	(AIR) carboxylase
G5B99_RS00335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G5B99_RS00340	COG1120	ATPase activity
G5B99_RS00350	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
G5B99_RS00365	COG2831	hemolysin activation secretion protein
G5B99_RS00370	COG3210	domain, Protein
G5B99_RS00570	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G5B99_RS00575	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
G5B99_RS00585	COG0745	RESPONSE REGULATOR receiver
G5B99_RS00600	COG0352	thiamine-phosphate diphosphorylase activity
G5B99_RS00600	COG0351	phosphomethylpyrimidine kinase
G5B99_RS00615	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
G5B99_RS00620	COG0237	dephospho-CoA kinase activity
G5B99_RS00630	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
G5B99_RS00635	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
G5B99_RS00640	COG0291	Belongs to the bacterial ribosomal protein bL35 family
G5B99_RS00650	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
G5B99_RS00690	COG1115	amino acid carrier protein
G5B99_RS00700	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
G5B99_RS00700	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
G5B99_RS00715	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
G5B99_RS00720	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G5B99_RS00725	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
G5B99_RS00730	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
G5B99_RS00740	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
G5B99_RS00755	COG0439	Biotin carboxylase
G5B99_RS00765	COG1981	membrane
G5B99_RS00775	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
G5B99_RS00780	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
G5B99_RS00785	COG0268	Binds directly to 16S ribosomal RNA
G5B99_RS00790	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
G5B99_RS00800	COG1053	succinate dehydrogenase
G5B99_RS00815	COG0708	Exodeoxyribonuclease III
G5B99_RS00820	COG5001	Diguanylate cyclase
G5B99_RS00820	COG1716	ATPase activity
G5B99_RS00825	COG1858	cytochrome C peroxidase
G5B99_RS00845	COG1108	ABC-type Mn2 Zn2 transport systems permease components
G5B99_RS00850	COG1121	(ABC) transporter
G5B99_RS00860	COG0803	Belongs to the bacterial solute-binding protein 9 family
G5B99_RS00860	COG3443	Belongs to the bacterial solute-binding protein 9 family
G5B99_RS00890	COG1971	Probably functions as a manganese efflux pump
G5B99_RS00905	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
G5B99_RS00915	COG0318	PFAM AMP-dependent synthetase and ligase
G5B99_RS00925	COG1157	protein secretion by the type III secretion system
G5B99_RS00930	COG0302	gtp cyclohydrolase
G5B99_RS00935	COG0544	peptidyl-prolyl cis-trans isomerase activity
G5B99_RS00940	COG0740	serine-type endopeptidase activity
G5B99_RS00950	COG0242	peptide deformylase activity
G5B99_RS00955	COG0606	chelatase, subunit chli
G5B99_RS00960	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
G5B99_RS00960	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
G5B99_RS00965	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
G5B99_RS00970	COG0861	Integral membrane protein TerC family
G5B99_RS01045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
G5B99_RS01050	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
G5B99_RS01055	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
G5B99_RS01060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G5B99_RS01070	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
G5B99_RS01075	COG1968	undecaprenyl-diphosphatase activity
G5B99_RS01085	COG2921	Belongs to the UPF0250 family
G5B99_RS01090	COG0315	cyclic pyranopterin monophosphate synthase activity
G5B99_RS01100	COG4263	nitrous-oxide reductase activity
G5B99_RS01115	COG0437	4 iron, 4 sulfur cluster binding
G5B99_RS01130	COG0348	domain, Protein
G5B99_RS01155	COG4773	Receptor
G5B99_RS01165	COG0025	NhaP-type Na H and K H
G5B99_RS01195	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
G5B99_RS01205	COG0733	neurotransmitter:sodium symporter activity
G5B99_RS01210	COG1253	flavin adenine dinucleotide binding
G5B99_RS01225	COG1704	LemA family
G5B99_RS01250	COG0251	oxidation-reduction process
G5B99_RS01290	COG0717	Belongs to the dCTP deaminase family
G5B99_RS01300	COG1086	Polysaccharide biosynthesis protein
G5B99_RS01305	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G5B99_RS01315	COG2089	acid synthase
G5B99_RS01320	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
G5B99_RS01325	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
G5B99_RS01335	COG1083	cytidylyl-transferase
G5B99_RS01340	COG1028	Short-chain dehydrogenase reductase Sdr
G5B99_RS01350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
G5B99_RS01360	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
G5B99_RS01365	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
G5B99_RS01375	COG0569	domain protein
G5B99_RS01375	COG0475	glutathione-regulated potassium exporter activity
G5B99_RS01395	COG0500	methyltransferase
G5B99_RS01410	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
G5B99_RS01420	COG0725	ABC transporter, periplasmic molybdate-binding protein
G5B99_RS01455	COG4662	Binding-protein-dependent transport system inner membrane component
G5B99_RS01475	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
G5B99_RS01480	COG1987	bacterial-type flagellum assembly
G5B99_RS01495	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
G5B99_RS01500	COG0148	phosphopyruvate hydratase activity
G5B99_RS01515	COG0582	viral genome integration into host DNA
G5B99_RS01530	COG1929	Belongs to the glycerate kinase type-1 family
G5B99_RS01535	COG2610	gluconate transmembrane transporter activity
G5B99_RS01555	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
G5B99_RS01575	COG1596	polysaccharide export
G5B99_RS01575	COG1555	photosystem II stabilization
G5B99_RS01580	COG0511	ligase activity, forming carbon-carbon bonds
G5B99_RS01585	COG0439	Biotin carboxylase
G5B99_RS01590	COG0534	Mate efflux family protein
G5B99_RS01640	COG2814	Major facilitator Superfamily
G5B99_RS01655	COG0716	FMN binding
G5B99_RS01660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G5B99_RS01665	COG0318	PFAM AMP-dependent synthetase and ligase
G5B99_RS01665	COG0204	Acyl-transferase
G5B99_RS01670	COG0445	tRNA wobble uridine modification
G5B99_RS01675	COG0723	plastoquinol--plastocyanin reductase activity
G5B99_RS01680	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
G5B99_RS01685	COG2857	Cytochrome c1
G5B99_RS01705	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
G5B99_RS01710	COG0651	ATP synthesis coupled electron transport
G5B99_RS01715	COG0650	Formate hydrogenlyase subunit 4
G5B99_RS01720	COG4237	Hydrogenase 4 membrane
G5B99_RS01725	COG0651	ATP synthesis coupled electron transport
G5B99_RS01730	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
G5B99_RS01730	COG3261	NADH dehydrogenase
G5B99_RS01740	COG3260	NADH ubiquinone oxidoreductase 20
G5B99_RS01755	COG2116	formate transmembrane transporter activity
G5B99_RS01775	COG3300	MHYT domain
G5B99_RS01775	COG5001	Diguanylate cyclase
G5B99_RS01815	COG3787	Belongs to the UPF0306 family
G5B99_RS01825	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G5B99_RS01830	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G5B99_RS01835	COG0825	malonyl-CoA metabolic process
G5B99_RS01860	COG1496	oxidoreductase activity
G5B99_RS01870	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G5B99_RS01875	COG0052	Belongs to the universal ribosomal protein uS2 family
G5B99_RS01880	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
G5B99_RS01885	COG1136	(ABC) transporter
G5B99_RS01890	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
G5B99_RS01915	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
G5B99_RS01940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
G5B99_RS01955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
G5B99_RS01965	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
G5B99_RS01970	COG0469	pyruvate kinase activity
G5B99_RS02000	COG1028	Short-chain dehydrogenase reductase Sdr
G5B99_RS02005	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
G5B99_RS02025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G5B99_RS02030	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
G5B99_RS02045	COG0463	Glycosyl transferase, family 2
G5B99_RS02050	COG0824	Thioesterase
G5B99_RS02070	COG1546	Belongs to the CinA family
G5B99_RS02070	COG1058	Belongs to the CinA family
G5B99_RS02075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
G5B99_RS02080	COG0154	amidase activity
G5B99_RS02085	COG0517	IMP dehydrogenase activity
G5B99_RS02085	COG0516	GMP reductase activity
G5B99_RS02090	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
G5B99_RS02095	COG1722	exodeoxyribonuclease VII activity
G5B99_RS02105	COG0519	Catalyzes the synthesis of GMP from XMP
G5B99_RS02110	COG3976	FMN-binding domain protein
G5B99_RS02110	COG1053	succinate dehydrogenase
G5B99_RS02115	COG2315	Protein conserved in bacteria
G5B99_RS02135	COG1193	negative regulation of DNA recombination
G5B99_RS02140	COG2199	diguanylate cyclase activity
G5B99_RS02140	COG2200	EAL domain
G5B99_RS02140	COG3287	FIST C domain
G5B99_RS02145	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
G5B99_RS02170	COG3875	lactate racemase activity
G5B99_RS02175	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
G5B99_RS02180	COG1606	tRNA processing
G5B99_RS02185	COG1691	(AIR) carboxylase
G5B99_RS02195	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
G5B99_RS02200	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
G5B99_RS02205	COG2186	Transcriptional regulator
G5B99_RS02210	COG0252	asparaginase activity
G5B99_RS02235	COG0848	biopolymer transport protein
G5B99_RS02240	COG0811	peptide transport
G5B99_RS02245	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
G5B99_RS02250	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G5B99_RS02260	COG0261	This protein binds to 23S rRNA in the presence of protein L20
G5B99_RS02265	COG0211	Belongs to the bacterial ribosomal protein bL27 family
G5B99_RS02280	COG0438	transferase activity, transferring glycosyl groups
G5B99_RS02285	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G5B99_RS02300	COG0351	phosphomethylpyrimidine kinase
G5B99_RS02305	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
G5B99_RS02305	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
G5B99_RS02310	COG1192	Involved in chromosome partitioning
G5B99_RS02315	COG1475	DNA binding
G5B99_RS02325	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
G5B99_RS02330	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G5B99_RS02335	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
G5B99_RS02340	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
G5B99_RS02345	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
G5B99_RS02350	COG0355	proton-transporting ATP synthase activity, rotational mechanism
G5B99_RS02355	COG0811	peptide transport
G5B99_RS02360	COG0848	biopolymer transport protein
G5B99_RS02370	COG0823	Involved in the tonB-independent uptake of proteins
G5B99_RS02385	COG1047	Peptidyl-prolyl cis-trans
G5B99_RS02390	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
G5B99_RS02395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
G5B99_RS02400	COG0037	tRNA processing
G5B99_RS02435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
G5B99_RS02445	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
G5B99_RS02450	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
G5B99_RS02455	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
G5B99_RS02460	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
G5B99_RS02465	COG0287	Prephenate dehydrogenase
G5B99_RS02475	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
G5B99_RS02485	COG0083	homoserine kinase activity
G5B99_RS02495	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
G5B99_RS02505	COG0779	Required for maturation of 30S ribosomal subunits
G5B99_RS02510	COG2759	Belongs to the formate--tetrahydrofolate ligase family
G5B99_RS02530	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
G5B99_RS02535	COG0733	neurotransmitter:sodium symporter activity
G5B99_RS02540	COG0733	neurotransmitter:sodium symporter activity
G5B99_RS02545	COG0733	neurotransmitter:sodium symporter activity
G5B99_RS02575	COG1301	dicarboxylic acid transport
G5B99_RS02580	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
G5B99_RS02585	COG0217	transcriptional regulatory protein
G5B99_RS02600	COG2217	Heavy metal translocating P-type atpase
G5B99_RS02615	COG0165	Argininosuccinate lyase
G5B99_RS02625	COG0537	adenosine 5'-monophosphoramidase activity
G5B99_RS02630	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
G5B99_RS02640	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
G5B99_RS02645	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
G5B99_RS02650	COG0539	negative regulation of cytoplasmic translation
G5B99_RS02650	COG1185	polyribonucleotide nucleotidyltransferase activity
G5B99_RS02660	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
G5B99_RS02665	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
G5B99_RS02680	COG0693	protein deglycase activity
G5B99_RS02685	COG0724	RNA recognition motif
G5B99_RS02690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G5B99_RS02695	COG0587	DNA-directed DNA polymerase activity
G5B99_RS02710	COG0642	Histidine kinase
G5B99_RS02725	COG0351	phosphomethylpyrimidine kinase
G5B99_RS02725	COG0352	thiamine-phosphate diphosphorylase activity
G5B99_RS02730	COG0352	thiamine-phosphate diphosphorylase activity
G5B99_RS02735	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
G5B99_RS02755	COG0772	Belongs to the SEDS family
G5B99_RS02760	COG0564	pseudouridine synthase activity
G5B99_RS02770	COG3103	Sh3 type 3 domain protein
G5B99_RS02770	COG0366	Alpha amylase catalytic
G5B99_RS02775	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G5B99_RS02780	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G5B99_RS02795	COG0528	UMP kinase activity
G5B99_RS02800	COG1758	RNA polymerase activity
G5B99_RS02805	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
G5B99_RS02810	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
G5B99_RS02815	COG2070	2-Nitropropane dioxygenase
G5B99_RS02825	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
G5B99_RS02825	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
G5B99_RS02835	COG2814	Major facilitator Superfamily
G5B99_RS02855	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
G5B99_RS02865	COG1185	polyribonucleotide nucleotidyltransferase activity
G5B99_RS02880	COG0616	signal peptide processing
G5B99_RS02885	COG0402	S-adenosylhomocysteine deaminase activity
G5B99_RS02890	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
G5B99_RS02895	COG0006	proline dipeptidase activity
G5B99_RS02900	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
G5B99_RS02905	COG1419	protein localization to endoplasmic reticulum
G5B99_RS02910	COG0455	bacterial-type flagellum organization
G5B99_RS02925	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G5B99_RS02930	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G5B99_RS02930	COG1776	CheC inhibitor of MCP methylation
G5B99_RS02935	COG1611	Belongs to the LOG family
G5B99_RS02940	COG0482	sulfurtransferase activity
G5B99_RS02965	COG2205	protein histidine kinase activity
G5B99_RS02970	COG1433	Dinitrogenase iron-molybdenum cofactor
G5B99_RS02970	COG0535	radical SAM domain protein
G5B99_RS02995	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
G5B99_RS03005	COG0563	adenylate kinase activity
G5B99_RS03010	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
G5B99_RS03020	COG0497	DNA recombination
G5B99_RS03030	COG0084	hydrolase, TatD family'
G5B99_RS03040	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
G5B99_RS03045	COG0131	Imidazoleglycerol-phosphate dehydratase
G5B99_RS03050	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
G5B99_RS03065	COG0218	Necessary for normal cell division and for the maintenance of normal septation
G5B99_RS03075	COG0768	penicillin binding
G5B99_RS03080	COG1151	hydroxylamine reductase activity
G5B99_RS03090	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
G5B99_RS03095	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
G5B99_RS03105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G5B99_RS03105	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
G5B99_RS03115	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
G5B99_RS03120	COG1763	Mo-molybdopterin cofactor biosynthetic process
G5B99_RS03140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G5B99_RS03145	COG1970	mechanosensitive ion channel activity
G5B99_RS03165	COG1408	metallophosphoesterase
G5B99_RS03170	COG0688	phosphatidylethanolamine metabolic process
G5B99_RS03175	COG0012	GTP binding
G5B99_RS03180	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
G5B99_RS03190	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
G5B99_RS03200	COG0698	ribose 5-phosphate isomerase
G5B99_RS03210	COG1994	Peptidase M50
G5B99_RS03215	COG0681	Belongs to the peptidase S26 family
G5B99_RS03220	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
G5B99_RS03230	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
G5B99_RS03255	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G5B99_RS03260	COG2201	protein-glutamate methylesterase activity
G5B99_RS03265	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
G5B99_RS03300	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
G5B99_RS03305	COG0612	Peptidase, M16
G5B99_RS03310	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
G5B99_RS03320	COG1120	ATPase activity
G5B99_RS03325	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
G5B99_RS03345	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
G5B99_RS03380	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
G5B99_RS03390	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
G5B99_RS03395	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
G5B99_RS03400	COG1049	propionate catabolic process, 2-methylcitrate cycle
G5B99_RS03415	COG1757	Na H antiporter
G5B99_RS03420	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
G5B99_RS03425	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
G5B99_RS03430	COG1404	Belongs to the peptidase S8 family
G5B99_RS03445	COG2837	iron assimilation
G5B99_RS03460	COG0243	molybdopterin cofactor binding
G5B99_RS03470	COG0243	molybdopterin cofactor binding
G5B99_RS03475	COG0437	4 iron, 4 sulfur cluster binding
G5B99_RS03480	COG0348	domain, Protein
G5B99_RS03485	COG3043	anaerobic respiration
G5B99_RS03505	COG0840	transmembrane signaling receptor activity
G5B99_RS03535	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
G5B99_RS03555	COG0501	Belongs to the peptidase M48B family
G5B99_RS03570	COG0357	Ribosomal RNA small subunit methyltransferase G
G5B99_RS03575	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G5B99_RS03580	COG0113	porphobilinogen synthase activity
G5B99_RS03585	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
G5B99_RS03595	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G5B99_RS03620	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G5B99_RS03665	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
G5B99_RS03670	COG0267	Belongs to the bacterial ribosomal protein bL33 family
G5B99_RS03685	COG0250	Participates in transcription elongation, termination and antitermination
G5B99_RS03690	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
G5B99_RS03695	COG0081	regulation of translation
G5B99_RS03700	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
G5B99_RS03705	COG0222	ribosome binding
G5B99_RS03710	COG0085	RNA polymerase activity
G5B99_RS03715	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
G5B99_RS03725	COG1757	Na H antiporter
G5B99_RS03730	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
G5B99_RS03735	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
G5B99_RS03740	COG0049	tRNA binding
G5B99_RS03745	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
G5B99_RS03760	COG0783	Belongs to the Dps family
G5B99_RS03775	COG4773	Receptor
G5B99_RS03785	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G5B99_RS03785	COG1333	cytochrome c biogenesis protein
G5B99_RS03805	COG1558	bacterial-type flagellum-dependent cell motility
G5B99_RS03810	COG1815	bacterial-type flagellum-dependent cell motility
G5B99_RS03820	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
G5B99_RS03830	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
G5B99_RS03835	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
G5B99_RS03855	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
G5B99_RS03860	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
G5B99_RS03865	COG0815	Transfers the fatty acyl group on membrane lipoproteins
G5B99_RS03870	COG1862	Preprotein translocase
G5B99_RS03875	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G5B99_RS03880	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
G5B99_RS03890	COG0495	leucyl-tRNA aminoacylation
G5B99_RS03910	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
G5B99_RS03925	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
G5B99_RS03930	COG1045	serine acetyltransferase
G5B99_RS03945	COG0227	Belongs to the bacterial ribosomal protein bL28 family
G5B99_RS03960	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
G5B99_RS03975	COG0733	neurotransmitter:sodium symporter activity
G5B99_RS03985	COG0501	Belongs to the peptidase M48B family
G5B99_RS04005	COG3610	response to peptide
G5B99_RS04010	COG0824	Thioesterase
G5B99_RS04020	COG1573	uracil-dna glycosylase
G5B99_RS04025	COG0230	Belongs to the bacterial ribosomal protein bL34 family
G5B99_RS04035	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
G5B99_RS04040	COG0706	membrane insertase activity
G5B99_RS04050	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
G5B99_RS04055	COG2249	NAD(P)H dehydrogenase (quinone) activity
G5B99_RS04065	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G5B99_RS04075	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
G5B99_RS04090	COG0138	bifunctional purine biosynthesis protein purh
G5B99_RS04110	COG2151	metal-sulfur cluster biosynthetic enzyme
G5B99_RS04115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
G5B99_RS04120	COG0849	cell division
G5B99_RS04135	COG0275	rRNA processing
G5B99_RS04160	COG1683	Conserved Protein
G5B99_RS04175	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
G5B99_RS04190	COG0653	protein targeting
G5B99_RS04195	COG4591	ABC-type transport system involved in lipoprotein release permease component
G5B99_RS04200	COG0475	glutathione-regulated potassium exporter activity
G5B99_RS04200	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
G5B99_RS04205	COG0789	Transcriptional regulator
G5B99_RS04210	COG0484	heat shock protein binding
G5B99_RS04215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
G5B99_RS04220	COG0745	RESPONSE REGULATOR receiver
G5B99_RS04225	COG0642	Histidine kinase
G5B99_RS04270	COG0142	geranyltranstransferase activity
G5B99_RS04275	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
G5B99_RS04280	COG0442	prolyl-tRNA aminoacylation
G5B99_RS04290	COG0181	hydroxymethylbilane synthase activity
G5B99_RS04305	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
G5B99_RS04310	COG2195	Cleaves the N-terminal amino acid of tripeptides
G5B99_RS04315	COG0700	Nucleoside recognition
G5B99_RS04320	COG3366	ferrous iron transmembrane transporter activity
G5B99_RS04330	COG0494	nUDIX hydrolase
G5B99_RS04340	COG0739	heme binding
G5B99_RS04360	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
G5B99_RS04370	COG0642	Histidine kinase
G5B99_RS04375	COG0745	RESPONSE REGULATOR receiver
G5B99_RS04400	COG0776	regulation of translation
G5B99_RS04405	COG3022	response to hydroperoxide
G5B99_RS04410	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
G5B99_RS04415	COG1674	ftsk spoiiie
G5B99_RS04415	COG1196	nuclear chromosome segregation
G5B99_RS04440	COG2863	cytochrome
G5B99_RS04450	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
G5B99_RS04455	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
G5B99_RS04455	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
G5B99_RS04460	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
G5B99_RS04485	COG2204	response regulator
G5B99_RS04490	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
G5B99_RS04500	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
G5B99_RS04505	COG0731	radical SAM domain protein
G5B99_RS04520	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
G5B99_RS04530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G5B99_RS04535	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
G5B99_RS04540	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
G5B99_RS04555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
G5B99_RS04570	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
G5B99_RS04575	COG1924	4 iron, 4 sulfur cluster binding
G5B99_RS04600	COG2121	Domain of unknown function (DUF374)
G5B99_RS04605	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G5B99_RS04615	COG0195	Participates in both transcription termination and antitermination
G5B99_RS04635	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
G5B99_RS04645	COG0251	oxidation-reduction process
G5B99_RS04650	COG2964	Protein conserved in bacteria
G5B99_RS04655	COG2217	Heavy metal translocating P-type atpase
G5B99_RS04675	COG0174	glutamine synthetase
G5B99_RS04690	COG0826	peptidase U32
G5B99_RS04695	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
G5B99_RS04710	COG0752	glycyl-tRNA synthetase alpha subunit
G5B99_RS04715	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
G5B99_RS04725	COG1519	Transferase
G5B99_RS04725	COG0220	tRNA (guanine-N7-)-methyltransferase activity
G5B99_RS04730	COG0564	pseudouridine synthase activity
G5B99_RS04735	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
G5B99_RS04740	COG0228	four-way junction DNA binding
G5B99_RS04750	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
G5B99_RS04760	COG0335	large ribosomal subunit rRNA binding
G5B99_RS04770	COG0343	queuine tRNA-ribosyltransferase activity
G5B99_RS04775	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
G5B99_RS04780	COG1127	ABC transporter
G5B99_RS04800	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
G5B99_RS04810	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
G5B99_RS04815	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G5B99_RS04820	COG0521	Mo-molybdopterin cofactor biosynthetic process
G5B99_RS04840	COG2022	thiamine diphosphate biosynthetic process
G5B99_RS04860	COG1166	arginine decarboxylase activity
G5B99_RS04865	COG0124	histidyl-tRNA synthetase
G5B99_RS04870	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
G5B99_RS04875	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
G5B99_RS04880	COG0163	prenyltransferase activity
G5B99_RS04895	COG0303	'Molybdopterin
G5B99_RS04900	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
G5B99_RS04915	COG2833	Protein of unknown function (DUF455)
G5B99_RS04925	COG0840	transmembrane signaling receptor activity
G5B99_RS04930	COG0840	transmembrane signaling receptor activity
G5B99_RS04980	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
G5B99_RS04985	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
G5B99_RS04990	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
G5B99_RS04995	COG0359	binds to the 23S rRNA
G5B99_RS05000	COG0137	argininosuccinate synthase activity
G5B99_RS05005	COG4771	TonB-dependent receptor
G5B99_RS05015	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
G5B99_RS05020	COG0802	atpase or kinase
G5B99_RS05030	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
G5B99_RS05060	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
G5B99_RS05065	COG0772	Belongs to the SEDS family
G5B99_RS05070	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
G5B99_RS05075	COG0586	Pfam SNARE associated Golgi protein
G5B99_RS05080	COG1464	Belongs to the NlpA lipoprotein family
G5B99_RS05085	COG1464	Belongs to the NlpA lipoprotein family
G5B99_RS05090	COG2011	ABC-type metal ion transport system permease component
G5B99_RS05095	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G5B99_RS05105	COG2373	Large extracellular alpha-helical protein
G5B99_RS05110	COG4953	penicillin-binding protein 1C
G5B99_RS05120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G5B99_RS05130	COG1538	Outer membrane efflux protein
G5B99_RS05155	COG0542	response to heat
G5B99_RS05160	COG0793	Belongs to the peptidase S41A family
G5B99_RS05165	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
G5B99_RS05170	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
G5B99_RS05175	COG0047	phosphoribosylformylglycinamidine synthase activity
G5B99_RS05185	COG0204	Acyl-transferase
G5B99_RS05190	COG0840	transmembrane signaling receptor activity
G5B99_RS05195	COG0326	Molecular chaperone. Has ATPase activity
G5B99_RS05205	COG2048	Heterodisulfide reductase, subunit B
G5B99_RS05210	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G5B99_RS05215	COG1053	succinate dehydrogenase
G5B99_RS05235	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
G5B99_RS05235	COG0674	pyruvate-flavodoxin oxidoreductase activity
G5B99_RS05245	COG0039	L-malate dehydrogenase activity
G5B99_RS05255	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
G5B99_RS05270	COG0309	Hydrogenase expression formation protein (HypE)
G5B99_RS05275	COG0409	Hydrogenase expression formation protein
G5B99_RS05280	COG0298	carbon dioxide binding
G5B99_RS05285	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
G5B99_RS05300	COG0864	Transcriptional regulator
G5B99_RS05305	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
G5B99_RS05315	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
G5B99_RS05320	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
G5B99_RS05325	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
G5B99_RS05330	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
G5B99_RS05335	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
G5B99_RS05340	COG0280	phosphate acetyltransferase
G5B99_RS05345	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
G5B99_RS05350	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G5B99_RS05355	COG0440	acetolactate synthase activity
G5B99_RS05360	COG0028	Belongs to the TPP enzyme family
G5B99_RS05370	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
G5B99_RS05380	COG0134	indole-3-glycerol-phosphate synthase activity
G5B99_RS05395	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
G5B99_RS05405	COG2072	flavoprotein involved in K transport
G5B99_RS05410	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
G5B99_RS05420	COG2962	Rard protein
G5B99_RS05430	COG1401	restriction endodeoxyribonuclease activity
G5B99_RS05455	COG0356	it plays a direct role in the translocation of protons across the membrane
G5B99_RS05460	COG0730	response to heat
G5B99_RS05475	COG4786	Flagellar basal body rod
G5B99_RS05475	COG1256	bacterial-type flagellum assembly
G5B99_RS05490	COG3951	Flagellar rod assembly protein muramidase FlgJ
G5B99_RS05535	COG0840	transmembrane signaling receptor activity
G5B99_RS05540	COG3340	Belongs to the peptidase S51 family
G5B99_RS05550	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
G5B99_RS05580	COG1181	Belongs to the D-alanine--D-alanine ligase family
G5B99_RS05585	COG0632	four-way junction helicase activity
G5B99_RS05595	COG0728	peptidoglycan biosynthetic process
G5B99_RS05600	COG0215	cysteine-tRNA ligase activity
G5B99_RS05605	COG1132	(ABC) transporter
G5B99_RS05610	COG0167	dihydroorotate dehydrogenase activity
G5B99_RS05620	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
G5B99_RS05625	COG1028	Short-chain dehydrogenase reductase Sdr
G5B99_RS05630	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
G5B99_RS05635	COG0628	permease
G5B99_RS05640	COG0750	zinc metalloprotease
G5B99_RS05645	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
G5B99_RS05670	COG1942	4-Oxalocrotonate Tautomerase
G5B99_RS05675	COG0481	GTPase activity
G5B99_RS05700	COG2910	NAD(P)H-binding
G5B99_RS05705	COG1959	2 iron, 2 sulfur cluster binding
G5B99_RS05770	COG1418	mRNA catabolic process
G5B99_RS05780	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
G5B99_RS05785	COG0552	protein localization to endoplasmic reticulum
G5B99_RS05795	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
G5B99_RS05815	COG0736	holo-[acyl-carrier-protein] synthase activity
G5B99_RS05820	COG1580	Controls the rotational direction of flagella during chemotaxis
G5B99_RS05825	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
G5B99_RS05835	COG2860	membrane
G5B99_RS05885	COG1115	amino acid carrier protein
G5B99_RS05895	COG0157	Belongs to the NadC ModD family
G5B99_RS05900	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
G5B99_RS05920	COG0488	(ABC) transporter
G5B99_RS05925	COG0534	Mate efflux family protein
G5B99_RS05955	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
G5B99_RS05970	COG0765	amino acid transport
G5B99_RS05975	COG4215	(ABC) transporter
G5B99_RS05985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G5B99_RS06000	COG0459	protein refolding
G5B99_RS06005	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
G5B99_RS06015	COG2223	nitrite transmembrane transporter activity
G5B99_RS06020	COG0556	nucleotide-excision repair
G5B99_RS06035	COG2165	general secretion pathway protein
G5B99_RS06040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
G5B99_RS06045	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
G5B99_RS06050	COG0305	Participates in initiation and elongation during chromosome replication
G5B99_RS06065	COG0697	spore germination
G5B99_RS06075	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
G5B99_RS06090	COG1338	Plays a role in the flagellum-specific transport system
G5B99_RS06095	COG2885	chlorophyll binding
G5B99_RS06100	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
G5B99_RS06105	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
G5B99_RS06120	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
G5B99_RS06125	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
G5B99_RS06140	COG3383	formate dehydrogenase (NAD+) activity
G5B99_RS06145	COG3383	formate dehydrogenase (NAD+) activity
G5B99_RS06150	COG0437	4 iron, 4 sulfur cluster binding
G5B99_RS06170	COG3839	Belongs to the ABC transporter superfamily
G5B99_RS06175	COG4662	Binding-protein-dependent transport system inner membrane component
G5B99_RS06180	COG2998	abc-type tungstate transport system, permease component
G5B99_RS06240	COG2252	PERMEase
G5B99_RS06245	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
G5B99_RS06250	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
G5B99_RS06255	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
G5B99_RS06285	COG2171	N-acyltransferase activity
G5B99_RS06290	COG3477	response to acidic pH
G5B99_RS06305	COG2848	UPF0210 protein
G5B99_RS06310	COG3830	Belongs to the UPF0237 family
G5B99_RS06315	COG0489	protein tyrosine kinase activity
G5B99_RS06320	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
G5B99_RS06325	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
G5B99_RS06325	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
G5B99_RS06330	COG0745	RESPONSE REGULATOR receiver
G5B99_RS06350	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
G5B99_RS06360	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
G5B99_RS06370	COG0424	maF-like protein
G5B99_RS06390	COG0751	glycine-tRNA ligase activity
G5B99_RS06405	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
G5B99_RS06410	COG0617	tRNA 3'-terminal CCA addition
G5B99_RS06425	COG0473	3-isopropylmalate dehydrogenase activity
G5B99_RS06430	COG0066	3-isopropylmalate dehydratase activity
G5B99_RS06460	COG0252	asparaginase activity
G5B99_RS06465	COG1687	branched-chain amino acid
G5B99_RS06470	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
G5B99_RS06490	COG4786	Flagellar basal body rod
G5B99_RS06495	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
G5B99_RS06505	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
G5B99_RS06525	COG0191	fructose-bisphosphate aldolase activity
G5B99_RS06530	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G5B99_RS06535	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
G5B99_RS06540	COG4232	protein-disulfide reductase activity
G5B99_RS06555	COG0443	Heat shock 70 kDa protein
G5B99_RS06560	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G5B99_RS06565	COG1420	regulation of RNA biosynthetic process
G5B99_RS06580	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
G5B99_RS06585	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
G5B99_RS06595	COG1663	tetraacyldisaccharide 4'-kinase activity
G5B99_RS06600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G5B99_RS06605	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
G5B99_RS06610	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
G5B99_RS06615	COG4773	Receptor
G5B99_RS06625	COG0500	methyltransferase
G5B99_RS06635	COG1305	Transglutaminase-like
G5B99_RS06650	COG2195	Cleaves the N-terminal amino acid of tripeptides
G5B99_RS06655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
G5B99_RS06660	COG0540	Belongs to the ATCase OTCase family
G5B99_RS06680	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
G5B99_RS06685	COG1959	2 iron, 2 sulfur cluster binding
G5B99_RS06690	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
G5B99_RS06695	COG0243	molybdopterin cofactor binding
G5B99_RS06700	COG3383	formate dehydrogenase (NAD+) activity
G5B99_RS06705	COG2890	protein-(glutamine-N5) methyltransferase activity
G5B99_RS06710	COG0196	riboflavin kinase activity
G5B99_RS06720	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
G5B99_RS06730	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
G5B99_RS06745	COG0527	aspartate kinase activity
G5B99_RS06750	COG0494	nUDIX hydrolase
G5B99_RS06760	COG4771	TonB-dependent receptor
G5B99_RS06770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G5B99_RS06775	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G5B99_RS06780	COG0805	protein transport
G5B99_RS06785	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
G5B99_RS06795	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
G5B99_RS06805	COG2861	carbohydrate metabolic process
G5B99_RS06810	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
G5B99_RS06820	COG0557	exoribonuclease II activity
G5B99_RS06830	COG0360	Binds together with S18 to 16S ribosomal RNA
G5B99_RS06835	COG0629	single-stranded DNA binding
G5B99_RS06840	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
G5B99_RS06845	COG1518	maintenance of DNA repeat elements
G5B99_RS06850	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
G5B99_RS06860	COG1203	CRISPR-associated helicase, Cas3
G5B99_RS06905	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G5B99_RS06905	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
G5B99_RS06910	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
G5B99_RS06935	COG0628	permease
G5B99_RS06945	COG2255	four-way junction helicase activity
G5B99_RS06960	COG3301	Polysulphide reductase, NrfD
G5B99_RS06965	COG0437	4 iron, 4 sulfur cluster binding
G5B99_RS06970	COG0243	molybdopterin cofactor binding
G5B99_RS06975	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
G5B99_RS06980	COG1027	Aspartate ammonia-lyase
G5B99_RS06985	COG0488	(ABC) transporter
G5B99_RS06990	COG3738	Protein conserved in bacteria
G5B99_RS06995	COG0166	Belongs to the GPI family
G5B99_RS07005	COG1739	Uncharacterized protein family UPF0029
G5B99_RS07010	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
G5B99_RS07020	COG1053	succinate dehydrogenase
G5B99_RS07025	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
G5B99_RS07055	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
G5B99_RS07075	COG0575	Belongs to the CDS family
G5B99_RS07085	COG0243	molybdopterin cofactor binding
G5B99_RS07105	COG0612	Peptidase, M16
G5B99_RS07115	COG0840	transmembrane signaling receptor activity
G5B99_RS07130	COG1126	abc transporter atp-binding protein
G5B99_RS07135	COG0765	amino acid transport
G5B99_RS07140	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
G5B99_RS07160	COG0519	Catalyzes the synthesis of GMP from XMP
G5B99_RS07165	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
G5B99_RS07205	COG4797	methyltransferase
G5B99_RS07205	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
G5B99_RS07210	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
G5B99_RS07215	COG1570	exodeoxyribonuclease VII activity
G5B99_RS07225	COG2954	triphosphatase activity
G5B99_RS07230	COG0735	belongs to the Fur family
G5B99_RS07235	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
G5B99_RS07245	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G5B99_RS07255	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
G5B99_RS07260	COG0077	Prephenate dehydratase
G5B99_RS07260	COG1605	Chorismate mutase
G5B99_RS07265	COG0019	diaminopimelate decarboxylase activity
G5B99_RS07275	COG0193	aminoacyl-tRNA hydrolase activity
G5B99_RS07280	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
G5B99_RS07290	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
G5B99_RS07300	COG0835	chemotaxis
G5B99_RS07305	COG2198	Histidine kinase
G5B99_RS07305	COG0643	Histidine kinase
G5B99_RS07305	COG0784	Response regulator, receiver
G5B99_RS07310	COG0784	Response regulator, receiver
G5B99_RS07310	COG0835	chemotaxis
G5B99_RS07320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
G5B99_RS07330	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
G5B99_RS07335	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
G5B99_RS07340	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
G5B99_RS07345	COG1183	phosphatidylcholine synthase activity
G5B99_RS07350	COG0688	phosphatidylethanolamine metabolic process
G5B99_RS07355	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
G5B99_RS07360	COG2264	protein methyltransferase activity
G5B99_RS07365	COG0745	RESPONSE REGULATOR receiver
G5B99_RS07370	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
G5B99_RS07375	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
G5B99_RS07385	COG1086	Polysaccharide biosynthesis protein
G5B99_RS07390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G5B99_RS07395	COG0110	maltose O-acetyltransferase activity
G5B99_RS07400	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G5B99_RS07405	COG0438	transferase activity, transferring glycosyl groups
G5B99_RS07415	COG0438	transferase activity, transferring glycosyl groups
G5B99_RS07425	COG0438	transferase activity, transferring glycosyl groups
G5B99_RS07430	COG1215	transferase activity, transferring glycosyl groups
G5B99_RS07440	COG2244	polysaccharide biosynthetic process
G5B99_RS07450	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
G5B99_RS07465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
G5B99_RS07470	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
G5B99_RS07475	COG1793	dna ligase
G5B99_RS07480	COG0519	Catalyzes the synthesis of GMP from XMP
G5B99_RS07495	COG0579	oxidoreductase
G5B99_RS07505	COG1902	pentaerythritol trinitrate reductase activity
G5B99_RS07515	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
G5B99_RS07520	COG0149	triose-phosphate isomerase activity
G5B99_RS07525	COG0126	phosphoglycerate kinase activity
G5B99_RS07540	COG2855	membrane
G5B99_RS07545	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
G5B99_RS07570	COG0367	asparagine synthase
G5B99_RS07580	COG2244	polysaccharide biosynthetic process
G5B99_RS07595	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
G5B99_RS07610	COG0367	asparagine synthase
G5B99_RS07635	COG0018	arginyl-trna synthetase
G5B99_RS07640	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
G5B99_RS07645	COG0194	GDP metabolic process
G5B99_RS07655	COG1684	flagellar biosynthetic protein fliR
G5B99_RS07665	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
G5B99_RS07695	COG0859	PFAM glycosyl transferase family 9
G5B99_RS07705	COG0463	Glycosyl transferase, family 2
G5B99_RS07710	COG0859	PFAM glycosyl transferase family 9
G5B99_RS07715	COG0438	transferase activity, transferring glycosyl groups
G5B99_RS07715	COG0297	glycogen (starch) synthase activity
G5B99_RS07720	COG0726	polysaccharide deacetylase
G5B99_RS07725	COG0726	polysaccharide deacetylase
G5B99_RS07740	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
G5B99_RS07750	COG0105	UTP biosynthetic process
G5B99_RS07760	COG0333	Belongs to the bacterial ribosomal protein bL32 family
G5B99_RS07765	COG0416	fatty acid biosynthetic process
G5B99_RS07770	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
G5B99_RS07775	COG0450	alkyl hydroperoxide reductase
G5B99_RS07790	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
G5B99_RS07805	COG0642	Histidine kinase
G5B99_RS07820	COG1776	CheC inhibitor of MCP methylation
G5B99_RS07820	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
G5B99_RS07835	COG0133	tryptophan synthase activity
G5B99_RS07845	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
G5B99_RS07845	COG0512	Glutamine amidotransferase of anthranilate synthase
G5B99_RS07850	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
G5B99_RS07855	COG0642	Histidine kinase
G5B99_RS07860	COG0745	RESPONSE REGULATOR receiver
G5B99_RS07865	COG0484	heat shock protein binding
G5B99_RS07870	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
G5B99_RS07875	COG1704	LemA family
G5B99_RS07900	COG0284	orotidine-5'-phosphate decarboxylase activity
G5B99_RS07905	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
G5B99_RS07910	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
G5B99_RS07930	COG2877	3-deoxy-8-phosphooctulonate synthase activity
G5B99_RS07940	COG1160	GTP binding
G5B99_RS07945	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
G5B99_RS07965	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
G5B99_RS07990	COG1136	(ABC) transporter
G5B99_RS07990	COG0577	efflux transmembrane transporter activity
G5B99_RS08000	COG0577	efflux transmembrane transporter activity
G5B99_RS08015	COG0672	)-iron permease
G5B99_RS08020	COG0437	4 iron, 4 sulfur cluster binding
G5B99_RS08030	COG0243	molybdopterin cofactor binding
G5B99_RS08050	COG1921	L-seryl-tRNASec selenium transferase activity
G5B99_RS08070	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
G5B99_RS08075	COG2732	(Barnase) inhibitor
G5B99_RS08085	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
G5B99_RS08090	COG0281	malic enzyme
G5B99_RS08090	COG0280	phosphate acetyltransferase
G5B99_RS08095	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
G5B99_RS08100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
G5B99_RS08110	COG4178	(ABC) transporter
G5B99_RS08120	COG0303	'Molybdopterin
G5B99_RS08130	COG0626	cystathionine gamma-synthase activity
G5B99_RS08135	COG1126	abc transporter atp-binding protein
G5B99_RS08140	COG0765	amino acid transport
G5B99_RS08145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
G5B99_RS08160	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
G5B99_RS08165	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
G5B99_RS08170	COG5001	Diguanylate cyclase
G5B99_RS08175	COG0778	Nitroreductase
G5B99_RS08210	COG0314	molybdopterin synthase activity
G5B99_RS08220	COG2814	Major facilitator Superfamily
G5B99_RS08235	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
G5B99_RS08240	COG2814	Major facilitator Superfamily
G5B99_RS08245	COG2081	HI0933 family
G5B99_RS08250	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G5B99_RS08265	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
G5B99_RS08270	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
G5B99_RS08275	COG1074	ATP-dependent DNA helicase activity
G5B99_RS08290	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
G5B99_RS08325	COG3278	Belongs to the heme-copper respiratory oxidase family
G5B99_RS08330	COG0745	RESPONSE REGULATOR receiver
G5B99_RS08345	COG0505	Belongs to the CarA family
G5B99_RS08360	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G5B99_RS08370	COG1077	Cell shape determining protein MreB Mrl
G5B99_RS08375	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
G5B99_RS08380	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
G5B99_RS08385	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
G5B99_RS08390	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
G5B99_RS08395	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
G5B99_RS08400	COG0444	Belongs to the ABC transporter superfamily
G5B99_RS08410	COG0601	transmembrane transport
G5B99_RS08430	COG1942	4-Oxalocrotonate Tautomerase
G5B99_RS08435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G5B99_RS08440	COG2194	sulfuric ester hydrolase activity
G5B99_RS08445	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
G5B99_RS08460	COG0140	phosphoribosyl-ATP diphosphatase activity
G5B99_RS08460	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
G5B99_RS08480	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
G5B99_RS08485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
G5B99_RS08490	COG0492	ferredoxin-NADP+ reductase activity
G5B99_RS08500	COG3118	belongs to the thioredoxin family
G5B99_RS08505	COG0792	nuclease activity
G5B99_RS08510	COG0460	homoserine dehydrogenase
G5B99_RS08515	COG0436	Aminotransferase
G5B99_RS08530	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
G5B99_RS08535	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
G5B99_RS08540	COG0254	rRNA binding
G5B99_RS08545	COG1385	rRNA (uridine-N3-)-methyltransferase activity
G5B99_RS08565	COG0602	queuosine metabolic process
G5B99_RS08570	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
G5B99_RS08595	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
G5B99_RS08605	COG1104	cysteine desulfurase activity
G5B99_RS08780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
G5B99_RS08790	COG0348	domain, Protein
G5B99_RS08795	COG0828	Belongs to the bacterial ribosomal protein bS21 family
G5B99_RS08810	COG0754	glutathionylspermidine amidase activity
G5B99_RS08815	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
G5B99_RS08825	COG1666	GTP binding
G5B99_RS08840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
G5B99_RS08845	COG4615	Cyclic peptide transporter
G5B99_RS08850	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G5B99_RS08855	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G5B99_RS08865	COG0649	NAD binding
G5B99_RS08885	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
G5B99_RS08890	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G5B99_RS08895	COG0839	Belongs to the complex I subunit 6 family
G5B99_RS08900	COG0713	ATP synthesis coupled electron transport
G5B99_RS08905	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
G5B99_RS08910	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
G5B99_RS08915	COG1007	ATP synthesis coupled electron transport
G5B99_RS08955	COG0203	ribosomal protein L17
G5B99_RS08960	COG0202	RNA polymerase activity
G5B99_RS08965	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
G5B99_RS08970	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
G5B99_RS08975	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G5B99_RS08980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
G5B99_RS08985	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
G5B99_RS08990	COG0024	Methionine aminopeptidase
G5B99_RS08995	COG0201	protein transport
G5B99_RS09000	COG0200	Binds to the 23S rRNA
G5B99_RS09005	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
G5B99_RS09010	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
G5B99_RS09015	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
G5B99_RS09020	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
G5B99_RS09025	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
G5B99_RS09030	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G5B99_RS09035	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
G5B99_RS09040	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
G5B99_RS09045	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
G5B99_RS09050	COG0255	Belongs to the universal ribosomal protein uL29 family
G5B99_RS09055	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
G5B99_RS09060	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
G5B99_RS09065	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
G5B99_RS09070	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
G5B99_RS09075	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G5B99_RS09080	COG0089	rRNA binding
G5B99_RS09085	COG0088	Forms part of the polypeptide exit tunnel
G5B99_RS09090	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
G5B99_RS09095	COG0051	transcription antitermination factor activity, RNA binding
G5B99_RS09110	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
G5B99_RS09120	COG0233	cytoplasmic translational termination
G5B99_RS09130	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
G5B99_RS09135	COG0352	thiamine-phosphate diphosphorylase activity
G5B99_RS09140	COG0670	Belongs to the BI1 family
G5B99_RS09145	COG0288	reversible hydration of carbon dioxide
G5B99_RS09150	COG0668	transmembrane transport
G5B99_RS09165	COG3706	GGDEF domain
G5B99_RS09185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
G5B99_RS09190	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
G5B99_RS09200	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
G5B99_RS09240	COG0515	serine threonine protein kinase
G5B99_RS09250	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G5B99_RS09265	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
G5B99_RS09295	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
G5B99_RS09320	COG1271	oxidase subunit
G5B99_RS09325	COG1294	oxidase, subunit
G5B99_RS09360	COG1322	Protein conserved in bacteria
G5B99_RS09370	COG1592	Rubrerythrin
G5B99_RS09405	COG4221	oxidoreductase activity
G5B99_RS09415	COG1979	alcohol dehydrogenase
G5B99_RS09440	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
G5B99_RS09445	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
G5B99_RS09450	COG0564	pseudouridine synthase activity
G5B99_RS09455	COG0820	rRNA (adenine-C2-)-methyltransferase activity
G5B99_RS09465	COG0107	imidazoleglycerol-phosphate synthase activity
G5B99_RS09475	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
G5B99_RS09480	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
G5B99_RS09485	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
G5B99_RS09485	COG0517	IMP dehydrogenase activity
G5B99_RS09490	COG1187	pseudouridine synthase activity
G5B99_RS09555	COG1333	cytochrome c biogenesis protein
G5B99_RS09555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
G5B99_RS09560	COG3301	Polysulphide reductase, NrfD
G5B99_RS09565	COG0437	4 iron, 4 sulfur cluster binding
G5B99_RS09570	COG0545	Peptidyl-prolyl cis-trans isomerase
G5B99_RS09575	COG0484	heat shock protein binding
G5B99_RS09580	COG3852	Histidine kinase
G5B99_RS09585	COG0745	RESPONSE REGULATOR receiver
G5B99_RS09590	COG0840	transmembrane signaling receptor activity
G5B99_RS09595	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
G5B99_RS09600	COG2056	Na+-H+ antiporter family
G5B99_RS09605	COG1749	Flagellar hook protein flgE
G5B99_RS09620	COG1854	S-ribosylhomocysteine lyase activity
G5B99_RS09625	COG0840	transmembrane signaling receptor activity
G5B99_RS09630	COG2258	MOSC domain
G5B99_RS09635	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group