locus-tag	class	description
CR44_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CR44_RS00010	COG0592	DNA-directed DNA polymerase activity
CR44_RS00015	COG0187	DNA topoisomerase II activity
CR44_RS00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CR44_RS00045	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CR44_RS00055	COG2814	Major facilitator Superfamily
CR44_RS00060	COG1217	gtp-binding protein TYPA
CR44_RS00085	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CR44_RS00135	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CR44_RS00150	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CR44_RS00155	COG0051	transcription antitermination factor activity, RNA binding
CR44_RS00160	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CR44_RS00165	COG0088	Forms part of the polypeptide exit tunnel
CR44_RS00170	COG0089	rRNA binding
CR44_RS00175	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CR44_RS00180	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CR44_RS00185	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CR44_RS00190	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CR44_RS00195	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CR44_RS00205	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CR44_RS00210	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CR44_RS00215	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CR44_RS00225	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CR44_RS00230	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CR44_RS00235	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CR44_RS00240	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CR44_RS00245	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CR44_RS00250	COG0200	Binds to the 23S rRNA
CR44_RS00255	COG0201	protein transport
CR44_RS00260	COG0024	Methionine aminopeptidase
CR44_RS00265	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CR44_RS00285	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CR44_RS00290	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CR44_RS00295	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CR44_RS00300	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CR44_RS00305	COG0202	RNA polymerase activity
CR44_RS00310	COG0203	ribosomal protein L17
CR44_RS00325	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CR44_RS00330	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CR44_RS00340	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CR44_RS00355	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CR44_RS00360	COG1012	belongs to the aldehyde dehydrogenase family
CR44_RS00370	COG1966	Carbon starvation protein
CR44_RS00390	COG3976	FMN-binding domain protein
CR44_RS00390	COG1053	succinate dehydrogenase
CR44_RS00405	COG2022	thiamine diphosphate biosynthetic process
CR44_RS00415	COG1739	Uncharacterized protein family UPF0029
CR44_RS00425	COG0166	Belongs to the GPI family
CR44_RS00430	COG0783	Belongs to the Dps family
CR44_RS00435	COG2353	YceI-like domain
CR44_RS00445	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CR44_RS00450	COG4106	trans-aconitate 2-methyltransferase activity
CR44_RS00490	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CR44_RS00515	COG3951	Flagellar rod assembly protein muramidase FlgJ
CR44_RS00550	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CR44_RS00555	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CR44_RS00585	COG0716	FMN binding
CR44_RS00590	COG1854	S-ribosylhomocysteine lyase activity
CR44_RS00595	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CR44_RS00600	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CR44_RS00605	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CR44_RS00610	COG1840	ABC-type Fe3 transport system, periplasmic component
CR44_RS00640	COG0348	domain, Protein
CR44_RS00645	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CR44_RS00660	COG3260	NADH ubiquinone oxidoreductase 20
CR44_RS00665	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CR44_RS00670	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CR44_RS00670	COG3261	NADH dehydrogenase
CR44_RS00675	COG0651	ATP synthesis coupled electron transport
CR44_RS00680	COG4237	Hydrogenase 4 membrane
CR44_RS00685	COG0650	Formate hydrogenlyase subunit 4
CR44_RS00690	COG0651	ATP synthesis coupled electron transport
CR44_RS00695	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CR44_RS00710	COG3976	FMN-binding domain protein
CR44_RS00710	COG1053	succinate dehydrogenase
CR44_RS00725	COG4191	Histidine kinase
CR44_RS00730	COG0745	RESPONSE REGULATOR receiver
CR44_RS00740	COG0315	cyclic pyranopterin monophosphate synthase activity
CR44_RS00760	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CR44_RS00765	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CR44_RS00770	COG0501	Belongs to the peptidase M48B family
CR44_RS00775	COG1620	l-lactate permease
CR44_RS00780	COG1253	flavin adenine dinucleotide binding
CR44_RS00815	COG1116	anion transmembrane transporter activity
CR44_RS00835	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CR44_RS00840	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CR44_RS00845	COG0649	NAD binding
CR44_RS00865	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CR44_RS00870	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CR44_RS00875	COG0839	Belongs to the complex I subunit 6 family
CR44_RS00880	COG0713	ATP synthesis coupled electron transport
CR44_RS00885	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CR44_RS00890	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CR44_RS00895	COG1007	ATP synthesis coupled electron transport
CR44_RS00905	COG0310	cobalt ion transport
CR44_RS00925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CR44_RS00930	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CR44_RS00935	COG0569	domain protein
CR44_RS00935	COG0475	glutathione-regulated potassium exporter activity
CR44_RS00940	COG0372	Belongs to the citrate synthase family
CR44_RS00945	COG1218	3'(2'),5'-bisphosphate nucleotidase
CR44_RS00950	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CR44_RS00955	COG0573	inorganic phosphate transmembrane transporter activity
CR44_RS00965	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CR44_RS00970	COG2814	Major facilitator Superfamily
CR44_RS01010	COG0314	molybdopterin synthase activity
CR44_RS01025	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CR44_RS01050	COG0148	phosphopyruvate hydratase activity
CR44_RS01055	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CR44_RS01060	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CR44_RS01090	COG0575	Belongs to the CDS family
CR44_RS01095	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CR44_RS01110	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CR44_RS01120	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CR44_RS01140	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CR44_RS01145	COG0602	queuosine metabolic process
CR44_RS01150	COG1979	alcohol dehydrogenase
CR44_RS01185	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CR44_RS01190	COG1360	Flagellar Motor Protein
CR44_RS01200	COG0105	UTP biosynthetic process
CR44_RS01210	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CR44_RS01215	COG0416	fatty acid biosynthetic process
CR44_RS01220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CR44_RS01235	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CR44_RS01245	COG0745	RESPONSE REGULATOR receiver
CR44_RS01255	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CR44_RS01270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CR44_RS01285	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CR44_RS01290	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CR44_RS01295	COG0450	alkyl hydroperoxide reductase
CR44_RS01310	COG1570	exodeoxyribonuclease VII activity
CR44_RS01335	COG1131	(ABC) transporter
CR44_RS01340	COG0842	Transport permease protein
CR44_RS01345	COG0842	Transport permease protein
CR44_RS01355	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CR44_RS01365	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CR44_RS01375	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CR44_RS01385	COG0647	UMP catabolic process
CR44_RS01390	COG0019	diaminopimelate decarboxylase activity
CR44_RS01405	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CR44_RS01415	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CR44_RS01420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CR44_RS01425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CR44_RS01430	COG1120	ATPase activity
CR44_RS01435	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CR44_RS01440	COG0811	peptide transport
CR44_RS01445	COG0848	biopolymer transport protein
CR44_RS01465	COG0254	rRNA binding
CR44_RS01470	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CR44_RS01475	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CR44_RS01490	COG0436	Aminotransferase
CR44_RS01495	COG0460	homoserine dehydrogenase
CR44_RS01500	COG0792	nuclease activity
CR44_RS01505	COG3118	belongs to the thioredoxin family
CR44_RS01510	COG0492	ferredoxin-NADP+ reductase activity
CR44_RS01520	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CR44_RS01525	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CR44_RS01540	COG0140	phosphoribosyl-ATP diphosphatase activity
CR44_RS01540	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CR44_RS01585	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CR44_RS01595	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CR44_RS01600	COG3059	membrane
CR44_RS01605	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CR44_RS01610	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CR44_RS01615	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CR44_RS01620	COG1077	Cell shape determining protein MreB Mrl
CR44_RS01630	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CR44_RS01655	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CR44_RS01660	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CR44_RS01680	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CR44_RS01695	COG0784	Response regulator, receiver
CR44_RS01695	COG0835	chemotaxis
CR44_RS01700	COG0784	Response regulator, receiver
CR44_RS01700	COG2198	Histidine kinase
CR44_RS01700	COG0643	Histidine kinase
CR44_RS01705	COG0835	chemotaxis
CR44_RS01715	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CR44_RS01725	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CR44_RS01730	COG0193	aminoacyl-tRNA hydrolase activity
CR44_RS01745	COG0709	Synthesizes selenophosphate from selenide and ATP
CR44_RS01750	COG0778	Nitroreductase
CR44_RS01755	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CR44_RS01760	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CR44_RS01765	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CR44_RS01795	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CR44_RS01800	COG0512	Glutamine amidotransferase of anthranilate synthase
CR44_RS01800	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CR44_RS01810	COG0133	tryptophan synthase activity
CR44_RS01825	COG1776	CheC inhibitor of MCP methylation
CR44_RS01825	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CR44_RS01845	COG3842	ATPase activity
CR44_RS01885	COG3300	MHYT domain
CR44_RS01885	COG5001	Diguanylate cyclase
CR44_RS01890	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CR44_RS01895	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CR44_RS01915	COG0505	Belongs to the CarA family
CR44_RS01925	COG3852	Histidine kinase
CR44_RS01930	COG0745	RESPONSE REGULATOR receiver
CR44_RS01935	COG3278	Belongs to the heme-copper respiratory oxidase family
CR44_RS01975	COG1074	ATP-dependent DNA helicase activity
CR44_RS01980	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CR44_RS01985	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CR44_RS01990	COG2885	chlorophyll binding
CR44_RS01995	COG0668	transmembrane transport
CR44_RS02005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CR44_RS02005	COG1013	pyruvate-flavodoxin oxidoreductase activity
CR44_RS02005	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CR44_RS02005	COG0674	pyruvate-flavodoxin oxidoreductase activity
CR44_RS02025	COG4773	Receptor
CR44_RS02030	COG4773	Receptor
CR44_RS02040	COG0683	leucine binding
CR44_RS02065	COG1333	cytochrome c biogenesis protein
CR44_RS02065	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CR44_RS02075	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CR44_RS02080	COG2046	Belongs to the sulfate adenylyltransferase family
CR44_RS02090	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CR44_RS02090	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CR44_RS02095	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CR44_RS02100	COG0489	protein tyrosine kinase activity
CR44_RS02105	COG2171	N-acyltransferase activity
CR44_RS02110	COG0488	(ABC) transporter
CR44_RS02115	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CR44_RS02120	COG1053	succinate dehydrogenase
CR44_RS02145	COG2217	Heavy metal translocating P-type atpase
CR44_RS02160	COG0814	amino acid
CR44_RS02165	COG0217	transcriptional regulatory protein
CR44_RS02170	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CR44_RS02175	COG1301	dicarboxylic acid transport
CR44_RS02180	COG1301	dicarboxylic acid transport
CR44_RS02190	COG0243	molybdopterin cofactor binding
CR44_RS02200	COG4999	Histidine kinase
CR44_RS02200	COG3850	Histidine kinase
CR44_RS02200	COG3437	response regulator, receiver
CR44_RS02200	COG2205	protein histidine kinase activity
CR44_RS02205	COG0745	RESPONSE REGULATOR receiver
CR44_RS02210	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CR44_RS02215	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CR44_RS02230	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CR44_RS02245	COG4263	nitrous-oxide reductase activity
CR44_RS02260	COG0437	4 iron, 4 sulfur cluster binding
CR44_RS02275	COG0348	domain, Protein
CR44_RS02280	COG3842	ATPase activity
CR44_RS02300	COG0642	Histidine kinase
CR44_RS02305	COG0745	RESPONSE REGULATOR receiver
CR44_RS02375	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CR44_RS02385	COG2255	four-way junction helicase activity
CR44_RS02390	COG0628	permease
CR44_RS02395	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CR44_RS02400	COG1127	ABC transporter
CR44_RS02415	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CR44_RS02440	COG3041	Addiction module toxin RelE StbE family
CR44_RS02520	COG0438	transferase activity, transferring glycosyl groups
CR44_RS02530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CR44_RS02535	COG0552	protein localization to endoplasmic reticulum
CR44_RS02540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CR44_RS02550	COG1418	mRNA catabolic process
CR44_RS02600	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CR44_RS02605	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CR44_RS02610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CR44_RS02615	COG0191	fructose-bisphosphate aldolase activity
CR44_RS02635	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CR44_RS02645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CR44_RS02650	COG4786	Flagellar basal body rod
CR44_RS02660	COG0672	)-iron permease
CR44_RS02685	COG1136	(ABC) transporter
CR44_RS02685	COG0577	efflux transmembrane transporter activity
CR44_RS02695	COG2957	Belongs to the agmatine deiminase family
CR44_RS02710	COG0786	glutamate:sodium symporter activity
CR44_RS02720	COG0534	Mate efflux family protein
CR44_RS02725	COG2205	protein histidine kinase activity
CR44_RS02740	COG0488	(ABC) transporter
CR44_RS02745	COG0733	neurotransmitter:sodium symporter activity
CR44_RS02750	COG0501	Belongs to the peptidase M48B family
CR44_RS02755	COG2890	protein-(glutamine-N5) methyltransferase activity
CR44_RS02770	COG0824	Thioesterase
CR44_RS02790	COG0004	ammonium transporteR
CR44_RS02795	COG0347	Belongs to the P(II) protein family
CR44_RS02800	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CR44_RS02805	COG0594	ribonuclease P activity
CR44_RS02810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CR44_RS02815	COG0706	membrane insertase activity
CR44_RS02825	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CR44_RS02830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CR44_RS02835	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CR44_RS02840	COG0138	bifunctional purine biosynthesis protein purh
CR44_RS02855	COG2151	metal-sulfur cluster biosynthetic enzyme
CR44_RS02860	COG0840	transmembrane signaling receptor activity
CR44_RS02885	COG0275	rRNA processing
CR44_RS02895	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CR44_RS02900	COG0849	cell division
CR44_RS02905	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CR44_RS02915	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CR44_RS02925	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CR44_RS02930	COG0653	protein targeting
CR44_RS02935	COG4591	ABC-type transport system involved in lipoprotein release permease component
CR44_RS02950	COG2814	Major facilitator Superfamily
CR44_RS02960	COG2252	PERMEase
CR44_RS02965	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CR44_RS02970	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CR44_RS02975	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CR44_RS02985	COG0425	Belongs to the sulfur carrier protein TusA family
CR44_RS02990	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CR44_RS02995	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CR44_RS03075	COG1546	Belongs to the CinA family
CR44_RS03075	COG1058	Belongs to the CinA family
CR44_RS03085	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CR44_RS03090	COG0154	amidase activity
CR44_RS03095	COG0517	IMP dehydrogenase activity
CR44_RS03095	COG0516	GMP reductase activity
CR44_RS03100	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CR44_RS03125	COG1902	pentaerythritol trinitrate reductase activity
CR44_RS03130	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CR44_RS03135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CR44_RS03155	COG1193	negative regulation of DNA recombination
CR44_RS03160	COG3287	FIST C domain
CR44_RS03160	COG2200	EAL domain
CR44_RS03160	COG2199	diguanylate cyclase activity
CR44_RS03170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CR44_RS03175	COG0579	oxidoreductase
CR44_RS03190	COG0612	Peptidase, M16
CR44_RS03195	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CR44_RS03200	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CR44_RS03205	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CR44_RS03210	COG2072	flavoprotein involved in K transport
CR44_RS03220	COG2813	Specifically methylates the guanine in position
CR44_RS03225	COG0727	PFAM Uncharacterised protein family (UPF0153)
CR44_RS03235	COG0134	indole-3-glycerol-phosphate synthase activity
CR44_RS03245	COG3022	response to hydroperoxide
CR44_RS03320	COG1518	maintenance of DNA repeat elements
CR44_RS03340	COG0439	Biotin carboxylase
CR44_RS03360	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CR44_RS03365	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CR44_RS03375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CR44_RS03380	COG1674	ftsk spoiiie
CR44_RS03380	COG1196	nuclear chromosome segregation
CR44_RS03395	COG0142	geranyltranstransferase activity
CR44_RS03400	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CR44_RS03405	COG0442	prolyl-tRNA aminoacylation
CR44_RS03415	COG0181	hydroxymethylbilane synthase activity
CR44_RS03420	COG1295	ribonuclease BN
CR44_RS03425	COG0277	FAD linked oxidase domain protein
CR44_RS03435	COG0739	heme binding
CR44_RS03440	COG2239	Acts as a magnesium transporter
CR44_RS03455	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CR44_RS03460	COG0459	protein refolding
CR44_RS03465	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CR44_RS03475	COG1677	Flagellar hook-basal body complex protein FliE
CR44_RS03485	COG1815	bacterial-type flagellum-dependent cell motility
CR44_RS03500	COG0542	response to heat
CR44_RS03505	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CR44_RS03515	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CR44_RS03520	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CR44_RS03535	COG0210	DNA helicase
CR44_RS03555	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CR44_RS03560	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CR44_RS03570	COG1121	(ABC) transporter
CR44_RS03575	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CR44_RS03580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CR44_RS03585	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CR44_RS03590	COG1862	Preprotein translocase
CR44_RS03595	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CR44_RS03600	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CR44_RS03610	COG0495	leucyl-tRNA aminoacylation
CR44_RS03625	COG0285	dihydrofolate synthase activity
CR44_RS03630	COG0739	heme binding
CR44_RS03640	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CR44_RS03670	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CR44_RS03680	COG2831	hemolysin activation secretion protein
CR44_RS03685	COG0101	tRNA pseudouridine synthase activity
CR44_RS03695	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CR44_RS03700	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CR44_RS03710	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CR44_RS03715	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CR44_RS03720	COG1338	Plays a role in the flagellum-specific transport system
CR44_RS03740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CR44_RS03745	COG1136	(ABC) transporter
CR44_RS03745	COG0577	efflux transmembrane transporter activity
CR44_RS03750	COG1538	Outer membrane efflux protein
CR44_RS03760	COG0642	Histidine kinase
CR44_RS03765	COG0745	RESPONSE REGULATOR receiver
CR44_RS03770	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CR44_RS03775	COG0484	heat shock protein binding
CR44_RS03780	COG0789	Transcriptional regulator
CR44_RS03785	COG0475	glutathione-regulated potassium exporter activity
CR44_RS03785	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CR44_RS03790	COG3263	regulation of cellular component size
CR44_RS03800	COG0730	response to heat
CR44_RS03805	COG0356	it plays a direct role in the translocation of protons across the membrane
CR44_RS03815	COG0352	thiamine-phosphate diphosphorylase activity
CR44_RS03820	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CR44_RS03825	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CR44_RS03840	COG2962	Rard protein
CR44_RS03845	COG1126	abc transporter atp-binding protein
CR44_RS03850	COG0765	amino acid transport
CR44_RS03855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CR44_RS03860	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CR44_RS03865	COG1028	Short-chain dehydrogenase reductase Sdr
CR44_RS03870	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CR44_RS03875	COG0612	Peptidase, M16
CR44_RS03880	COG0167	dihydroorotate dehydrogenase activity
CR44_RS03885	COG1132	(ABC) transporter
CR44_RS03890	COG0215	cysteine-tRNA ligase activity
CR44_RS03895	COG0728	peptidoglycan biosynthetic process
CR44_RS03930	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CR44_RS03940	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CR44_RS03940	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CR44_RS03970	COG0243	molybdopterin cofactor binding
CR44_RS03975	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CR44_RS03990	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CR44_RS03995	COG2201	protein-glutamate methylesterase activity
CR44_RS04005	COG0632	four-way junction helicase activity
CR44_RS04010	COG1181	Belongs to the D-alanine--D-alanine ligase family
CR44_RS04025	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CR44_RS04030	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CR44_RS04035	COG0280	phosphate acetyltransferase
CR44_RS04050	COG0028	Belongs to the TPP enzyme family
CR44_RS04055	COG0440	acetolactate synthase activity
CR44_RS04070	COG0586	Pfam SNARE associated Golgi protein
CR44_RS04075	COG0157	Belongs to the NadC ModD family
CR44_RS04080	COG0788	formyltetrahydrofolate deformylase activity
CR44_RS04085	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CR44_RS04090	COG1666	GTP binding
CR44_RS04095	COG0751	glycine-tRNA ligase activity
CR44_RS04105	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CR44_RS04110	COG0471	metal ion transport
CR44_RS04130	COG1115	amino acid carrier protein
CR44_RS04135	COG2217	Heavy metal translocating P-type atpase
CR44_RS04170	COG0739	heme binding
CR44_RS04180	COG0745	RESPONSE REGULATOR receiver
CR44_RS04185	COG0642	Histidine kinase
CR44_RS04190	COG0137	argininosuccinate synthase activity
CR44_RS04195	COG0582	viral genome integration into host DNA
CR44_RS04200	COG0772	Belongs to the SEDS family
CR44_RS04205	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CR44_RS04210	COG0776	regulation of translation
CR44_RS04215	COG0811	peptide transport
CR44_RS04220	COG0848	biopolymer transport protein
CR44_RS04230	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CR44_RS04235	COG0802	atpase or kinase
CR44_RS04245	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CR44_RS04250	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CR44_RS04260	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CR44_RS04265	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CR44_RS04270	COG0521	Mo-molybdopterin cofactor biosynthetic process
CR44_RS04285	COG1053	succinate dehydrogenase
CR44_RS04295	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CR44_RS04300	COG0750	zinc metalloprotease
CR44_RS04305	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CR44_RS04315	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CR44_RS04350	COG0556	nucleotide-excision repair
CR44_RS04360	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CR44_RS04365	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CR44_RS04375	COG4797	methyltransferase
CR44_RS04375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CR44_RS04380	COG0588	phosphoglycerate mutase activity
CR44_RS04385	COG2833	Protein of unknown function (DUF455)
CR44_RS04395	COG0247	lactate metabolic process
CR44_RS04400	COG1139	Iron-sulfur cluster binding protein
CR44_RS04415	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CR44_RS04420	COG0303	'Molybdopterin
CR44_RS04435	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CR44_RS04440	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CR44_RS04445	COG0124	histidyl-tRNA synthetase
CR44_RS04450	COG1166	arginine decarboxylase activity
CR44_RS04455	COG1045	serine acetyltransferase
CR44_RS04460	COG0436	Aminotransferase
CR44_RS04465	COG1442	glycosyl transferase family 8
CR44_RS04465	COG1216	Glycosyl transferase, family 2
CR44_RS04495	COG3962	Belongs to the TPP enzyme family
CR44_RS04500	COG0674	pyruvate-flavodoxin oxidoreductase activity
CR44_RS04500	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CR44_RS04510	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CR44_RS04515	COG0045	succinate-CoA ligase (ADP-forming) activity
CR44_RS04520	COG0039	L-malate dehydrogenase activity
CR44_RS04545	COG1012	belongs to the aldehyde dehydrogenase family
CR44_RS04550	COG1151	hydroxylamine reductase activity
CR44_RS04560	COG1959	2 iron, 2 sulfur cluster binding
CR44_RS04565	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CR44_RS04570	COG0736	holo-[acyl-carrier-protein] synthase activity
CR44_RS04575	COG1580	Controls the rotational direction of flagella during chemotaxis
CR44_RS04580	COG0179	Fumarylacetoacetate (FAA) hydrolase
CR44_RS04585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CR44_RS04590	COG2860	membrane
CR44_RS04610	COG0309	Hydrogenase expression formation protein (HypE)
CR44_RS04615	COG0409	Hydrogenase expression formation protein
CR44_RS04620	COG0298	carbon dioxide binding
CR44_RS04625	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CR44_RS04635	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CR44_RS04640	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CR44_RS04645	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CR44_RS04650	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
CR44_RS04655	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CR44_RS04660	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CR44_RS04670	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CR44_RS04675	COG0542	response to heat
CR44_RS04680	COG0793	Belongs to the peptidase S41A family
CR44_RS04685	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CR44_RS04690	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CR44_RS04695	COG0047	phosphoribosylformylglycinamidine synthase activity
CR44_RS04705	COG0204	Acyl-transferase
CR44_RS04710	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CR44_RS04720	COG3021	interspecies interaction between organisms
CR44_RS04730	COG0326	Molecular chaperone. Has ATPase activity
CR44_RS04740	COG0500	methyltransferase
CR44_RS04760	COG0114	fumarate hydratase activity
CR44_RS04775	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CR44_RS04780	COG2011	ABC-type metal ion transport system permease component
CR44_RS04790	COG3421	Type III restriction
CR44_RS04795	COG0352	thiamine-phosphate diphosphorylase activity
CR44_RS04795	COG0351	phosphomethylpyrimidine kinase
CR44_RS04805	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CR44_RS04815	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CR44_RS04830	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CR44_RS04835	COG4221	oxidoreductase activity
CR44_RS04850	COG0343	queuine tRNA-ribosyltransferase activity
CR44_RS04860	COG0305	Participates in initiation and elongation during chromosome replication
CR44_RS04865	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CR44_RS04875	COG2346	COG2346, Truncated hemoglobins
CR44_RS04885	COG1049	propionate catabolic process, 2-methylcitrate cycle
CR44_RS04890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CR44_RS04895	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CR44_RS04895	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CR44_RS04900	COG0359	binds to the 23S rRNA
CR44_RS04905	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CR44_RS04910	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CR44_RS04915	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CR44_RS04955	COG1459	type II secretion system
CR44_RS04960	COG0840	transmembrane signaling receptor activity
CR44_RS04975	COG0248	Ppx GppA phosphatase
CR44_RS04980	COG0617	tRNA 3'-terminal CCA addition
CR44_RS04995	COG0473	3-isopropylmalate dehydrogenase activity
CR44_RS05000	COG0066	3-isopropylmalate dehydratase activity
CR44_RS05020	COG0252	asparaginase activity
CR44_RS05025	COG1322	Protein conserved in bacteria
CR44_RS05035	COG2824	Alkylphosphonate utilization operon protein PhnA
CR44_RS05040	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CR44_RS05050	COG0424	maF-like protein
CR44_RS05065	COG0335	large ribosomal subunit rRNA binding
CR44_RS05070	COG0336	Belongs to the RNA methyltransferase TrmD family
CR44_RS05075	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CR44_RS05080	COG1837	Belongs to the UPF0109 family
CR44_RS05085	COG0228	four-way junction DNA binding
CR44_RS05090	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CR44_RS05095	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CR44_RS05110	COG0564	pseudouridine synthase activity
CR44_RS05115	COG1519	Transferase
CR44_RS05115	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CR44_RS05125	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CR44_RS05130	COG0752	glycyl-tRNA synthetase alpha subunit
CR44_RS05140	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CR44_RS05145	COG0826	peptidase U32
CR44_RS05160	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CR44_RS05165	COG0174	glutamine synthetase
CR44_RS05195	COG0753	catalase activity
CR44_RS05205	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CR44_RS05210	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CR44_RS05215	COG1414	Transcriptional regulator
CR44_RS05220	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CR44_RS05225	COG2721	sulfolactate sulfo-lyase activity
CR44_RS05235	COG0738	Major facilitator superfamily
CR44_RS05245	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CR44_RS05270	COG2195	Cleaves the N-terminal amino acid of tripeptides
CR44_RS05280	COG0500	methyltransferase
CR44_RS05285	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CR44_RS05285	COG2050	protein possibly involved in aromatic compounds catabolism
CR44_RS05290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CR44_RS05295	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CR44_RS05305	COG1663	tetraacyldisaccharide 4'-kinase activity
CR44_RS05310	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CR44_RS05315	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CR44_RS05320	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CR44_RS05330	COG3706	GGDEF domain
CR44_RS05350	COG0443	Heat shock 70 kDa protein
CR44_RS05355	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CR44_RS05360	COG1420	regulation of RNA biosynthetic process
CR44_RS05385	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CR44_RS05390	COG1959	2 iron, 2 sulfur cluster binding
CR44_RS05395	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CR44_RS05400	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CR44_RS05405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CR44_RS05440	COG2226	methyltransferase
CR44_RS05445	COG0196	riboflavin kinase activity
CR44_RS05455	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CR44_RS05460	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CR44_RS05465	COG0470	DNA polymerase III
CR44_RS05475	COG0527	aspartate kinase activity
CR44_RS05480	COG0494	nUDIX hydrolase
CR44_RS05485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CR44_RS05490	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CR44_RS05495	COG0805	protein transport
CR44_RS05500	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CR44_RS05515	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CR44_RS05520	COG0758	DNA mediated transformation
CR44_RS05530	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CR44_RS05540	COG0557	exoribonuclease II activity
CR44_RS05550	COG0360	Binds together with S18 to 16S ribosomal RNA
CR44_RS05555	COG0629	single-stranded DNA binding
CR44_RS05560	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CR44_RS05565	COG0484	heat shock protein binding
CR44_RS05570	COG0745	RESPONSE REGULATOR receiver
CR44_RS05575	COG0642	Histidine kinase
CR44_RS05590	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CR44_RS05605	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CR44_RS05610	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CR44_RS05630	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CR44_RS05650	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CR44_RS05655	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CR44_RS05660	COG1114	Component of the transport system for branched-chain amino acids
CR44_RS05665	COG1408	metallophosphoesterase
CR44_RS05670	COG0688	phosphatidylethanolamine metabolic process
CR44_RS05690	COG3043	anaerobic respiration
CR44_RS05695	COG0348	domain, Protein
CR44_RS05700	COG0437	4 iron, 4 sulfur cluster binding
CR44_RS05705	COG0243	molybdopterin cofactor binding
CR44_RS05710	COG0765	amino acid transport
CR44_RS05715	COG0765	amino acid transport
CR44_RS05720	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CR44_RS05725	COG1126	abc transporter atp-binding protein
CR44_RS05730	COG0012	GTP binding
CR44_RS05735	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CR44_RS05745	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CR44_RS05755	COG0698	ribose 5-phosphate isomerase
CR44_RS05760	COG1994	Peptidase M50
CR44_RS05765	COG0681	Belongs to the peptidase S26 family
CR44_RS05770	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CR44_RS05780	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CR44_RS05810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CR44_RS05830	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CR44_RS05850	COG0131	Imidazoleglycerol-phosphate dehydratase
CR44_RS05855	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CR44_RS05860	COG0791	NLP P60 protein
CR44_RS05860	COG1388	LysM domain
CR44_RS05865	COG0084	hydrolase, TatD family'
CR44_RS05870	COG3706	GGDEF domain
CR44_RS05875	COG0497	DNA recombination
CR44_RS05885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CR44_RS05890	COG0563	adenylate kinase activity
CR44_RS05895	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CR44_RS05900	COG0519	Catalyzes the synthesis of GMP from XMP
CR44_RS05910	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CR44_RS05910	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CR44_RS05915	COG0860	N-Acetylmuramoyl-L-alanine amidase
CR44_RS05925	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CR44_RS05935	COG1758	RNA polymerase activity
CR44_RS05940	COG0528	UMP kinase activity
CR44_RS05955	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CR44_RS05960	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CR44_RS05970	COG0564	pseudouridine synthase activity
CR44_RS05975	COG0772	Belongs to the SEDS family
CR44_RS05980	COG1999	signal sequence binding
CR44_RS05985	COG0840	transmembrane signaling receptor activity
CR44_RS06005	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CR44_RS06010	COG0765	amino acid transport
CR44_RS06015	COG1126	abc transporter atp-binding protein
CR44_RS06025	COG0352	thiamine-phosphate diphosphorylase activity
CR44_RS06030	COG1968	undecaprenyl-diphosphatase activity
CR44_RS06045	COG0642	Histidine kinase
CR44_RS06050	COG0587	DNA-directed DNA polymerase activity
CR44_RS06055	COG0724	RNA recognition motif
CR44_RS06060	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CR44_RS06060	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CR44_RS06060	COG0506	proline dehydrogenase activity
CR44_RS06070	COG3005	denitrification pathway
CR44_RS06075	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CR44_RS06090	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CR44_RS06095	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CR44_RS06105	COG1185	polyribonucleotide nucleotidyltransferase activity
CR44_RS06105	COG0539	negative regulation of cytoplasmic translation
CR44_RS06110	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CR44_RS06115	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CR44_RS06125	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CR44_RS06130	COG0537	adenosine 5'-monophosphoramidase activity
CR44_RS06140	COG1185	polyribonucleotide nucleotidyltransferase activity
CR44_RS06175	COG0519	Catalyzes the synthesis of GMP from XMP
CR44_RS06200	COG2201	protein-glutamate methylesterase activity
CR44_RS06205	COG3787	Belongs to the UPF0306 family
CR44_RS06240	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CR44_RS06245	COG1607	acyl-coa hydrolase
CR44_RS06260	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CR44_RS06270	COG1742	UPF0060 membrane protein
CR44_RS06280	COG2207	Transcriptional regulator
CR44_RS06285	COG1979	alcohol dehydrogenase
CR44_RS06305	COG0733	neurotransmitter:sodium symporter activity
CR44_RS06310	COG5016	pyruvate
CR44_RS06310	COG0511	ligase activity, forming carbon-carbon bonds
CR44_RS06315	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CR44_RS06320	COG0165	Argininosuccinate lyase
CR44_RS06330	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CR44_RS06360	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CR44_RS06365	COG0049	tRNA binding
CR44_RS06370	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CR44_RS06375	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CR44_RS06380	COG0085	RNA polymerase activity
CR44_RS06385	COG0222	ribosome binding
CR44_RS06390	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CR44_RS06395	COG0081	regulation of translation
CR44_RS06400	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CR44_RS06405	COG0250	Participates in transcription elongation, termination and antitermination
CR44_RS06420	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CR44_RS06425	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CR44_RS06460	COG0284	orotidine-5'-phosphate decarboxylase activity
CR44_RS06465	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CR44_RS06470	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CR44_RS06475	COG2076	Multidrug Resistance protein
CR44_RS06485	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CR44_RS06490	COG0697	spore germination
CR44_RS06495	COG1160	GTP binding
CR44_RS06510	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CR44_RS06520	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CR44_RS06525	COG1183	phosphatidylcholine synthase activity
CR44_RS06535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CR44_RS06540	COG2264	protein methyltransferase activity
CR44_RS06545	COG0745	RESPONSE REGULATOR receiver
CR44_RS06550	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CR44_RS06555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CR44_RS06565	COG1086	Polysaccharide biosynthesis protein
CR44_RS06570	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CR44_RS06575	COG2249	NAD(P)H dehydrogenase (quinone) activity
CR44_RS06590	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CR44_RS06605	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CR44_RS06610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CR44_RS06615	COG0825	malonyl-CoA metabolic process
CR44_RS06625	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CR44_RS06635	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CR44_RS06640	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CR44_RS06645	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CR44_RS06675	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CR44_RS06685	COG0195	Participates in both transcription termination and antitermination
CR44_RS06695	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CR44_RS06700	COG0438	transferase activity, transferring glycosyl groups
CR44_RS06710	COG0438	transferase activity, transferring glycosyl groups
CR44_RS06715	COG0438	transferase activity, transferring glycosyl groups
CR44_RS06720	COG0438	transferase activity, transferring glycosyl groups
CR44_RS06725	COG2244	polysaccharide biosynthetic process
CR44_RS06735	COG0463	Glycosyl transferase, family 2
CR44_RS06745	COG2246	polysaccharide biosynthetic process
CR44_RS06750	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CR44_RS06765	COG1793	dna ligase
CR44_RS06775	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CR44_RS06800	COG0859	PFAM glycosyl transferase family 9
CR44_RS06805	COG0726	polysaccharide deacetylase
CR44_RS06820	COG0859	PFAM glycosyl transferase family 9
CR44_RS06845	COG0859	PFAM glycosyl transferase family 9
CR44_RS06850	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CR44_RS06855	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CR44_RS06855	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CR44_RS06865	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CR44_RS06890	COG2217	Heavy metal translocating P-type atpase
CR44_RS06900	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CR44_RS06925	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CR44_RS06930	COG0149	triose-phosphate isomerase activity
CR44_RS06935	COG0126	phosphoglycerate kinase activity
CR44_RS06945	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CR44_RS06950	COG0799	negative regulation of ribosome biogenesis
CR44_RS06955	COG2855	membrane
CR44_RS06960	COG0583	DNA-binding transcription factor activity
CR44_RS06965	COG0018	arginyl-trna synthetase
CR44_RS06970	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CR44_RS06985	COG1684	flagellar biosynthetic protein fliR
CR44_RS06995	COG1136	(ABC) transporter
CR44_RS07000	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CR44_RS07005	COG0052	Belongs to the universal ribosomal protein uS2 family
CR44_RS07025	COG0445	tRNA wobble uridine modification
CR44_RS07030	COG0723	plastoquinol--plastocyanin reductase activity
CR44_RS07065	COG0731	radical SAM domain protein
CR44_RS07070	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CR44_RS07080	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CR44_RS07085	COG2204	response regulator
CR44_RS07120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CR44_RS07145	COG1942	4-Oxalocrotonate Tautomerase
CR44_RS07150	COG0481	GTPase activity
CR44_RS07155	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CR44_RS07160	COG0540	Belongs to the ATCase OTCase family
CR44_RS07190	COG0482	sulfurtransferase activity
CR44_RS07205	COG1611	Belongs to the LOG family
CR44_RS07210	COG0493	'glutamate synthase
CR44_RS07215	COG0069	glutamate synthase activity
CR44_RS07215	COG0067	glutamate synthase
CR44_RS07215	COG0070	glutamate synthase
CR44_RS07220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CR44_RS07220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CR44_RS07235	COG0779	Required for maturation of 30S ribosomal subunits
CR44_RS07245	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CR44_RS07255	COG0083	homoserine kinase activity
CR44_RS07265	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CR44_RS07270	COG0384	phenazine biosynthesis protein PhzF
CR44_RS07280	COG0287	Prephenate dehydrogenase
CR44_RS07285	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CR44_RS07290	COG0616	signal peptide processing
CR44_RS07295	COG0402	S-adenosylhomocysteine deaminase activity
CR44_RS07300	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CR44_RS07305	COG0006	proline dipeptidase activity
CR44_RS07310	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CR44_RS07315	COG1419	protein localization to endoplasmic reticulum
CR44_RS07320	COG0455	bacterial-type flagellum organization
CR44_RS07335	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CR44_RS07340	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CR44_RS07340	COG1776	CheC inhibitor of MCP methylation
CR44_RS07345	COG0037	tRNA processing
CR44_RS07350	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CR44_RS07360	COG1047	Peptidyl-prolyl cis-trans
CR44_RS07375	COG0823	Involved in the tonB-independent uptake of proteins
CR44_RS07385	COG0848	biopolymer transport protein
CR44_RS07390	COG0811	peptide transport
CR44_RS07395	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CR44_RS07400	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CR44_RS07405	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CR44_RS07410	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CR44_RS07415	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CR44_RS07425	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CR44_RS07430	COG1475	DNA binding
CR44_RS07435	COG1192	Involved in chromosome partitioning
CR44_RS07440	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CR44_RS07440	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CR44_RS07445	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CR44_RS07455	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CR44_RS07460	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CR44_RS07465	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CR44_RS07470	COG1858	cytochrome C peroxidase
CR44_RS07475	COG0437	4 iron, 4 sulfur cluster binding
CR44_RS07480	COG3383	formate dehydrogenase (NAD+) activity
CR44_RS07480	COG0243	molybdopterin cofactor binding
CR44_RS07485	COG0243	molybdopterin cofactor binding
CR44_RS07505	COG1921	L-seryl-tRNASec selenium transferase activity
CR44_RS07520	COG1083	cytidylyl-transferase
CR44_RS07550	COG2089	acid synthase
CR44_RS07555	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CR44_RS07560	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CR44_RS07565	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CR44_RS07570	COG0281	malic enzyme
CR44_RS07570	COG0280	phosphate acetyltransferase
CR44_RS07580	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CR44_RS07610	COG0717	Belongs to the dCTP deaminase family
CR44_RS07615	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CR44_RS07625	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CR44_RS07635	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CR44_RS07645	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CR44_RS07650	COG0113	porphobilinogen synthase activity
CR44_RS07655	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CR44_RS07660	COG0357	Ribosomal RNA small subunit methyltransferase G
CR44_RS07675	COG0501	Belongs to the peptidase M48B family
CR44_RS07720	COG3959	Transketolase, thiamine diphosphate binding domain
CR44_RS07760	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CR44_RS07765	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CR44_RS07770	COG0110	maltose O-acetyltransferase activity
CR44_RS07775	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CR44_RS07785	COG0859	PFAM glycosyl transferase family 9
CR44_RS07800	COG0367	asparagine synthase
CR44_RS07805	COG0438	transferase activity, transferring glycosyl groups
CR44_RS07835	COG0367	asparagine synthase
CR44_RS07890	COG0529	Catalyzes the synthesis of activated sulfate
CR44_RS07905	COG3848	Pyruvate phosphate dikinase
CR44_RS07905	COG0574	Belongs to the PEP-utilizing enzyme family
CR44_RS07910	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CR44_RS07910	COG0519	Catalyzes the synthesis of GMP from XMP
CR44_RS07915	COG1213	nucleotidyl transferase
CR44_RS07920	COG1086	Polysaccharide biosynthesis protein
CR44_RS07925	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CR44_RS07930	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CR44_RS07935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CR44_RS07940	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CR44_RS07940	COG4797	methyltransferase
CR44_RS07955	COG0628	permease
CR44_RS07960	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CR44_RS07965	COG0569	domain protein
CR44_RS07970	COG1027	Aspartate ammonia-lyase
CR44_RS07975	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CR44_RS07990	COG4771	TonB-dependent receptor
CR44_RS07995	COG0811	peptide transport
CR44_RS08000	COG0848	biopolymer transport protein
CR44_RS08010	COG0747	negative chemotaxis
CR44_RS08015	COG0601	transmembrane transport
CR44_RS08020	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CR44_RS08035	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CR44_RS08055	COG0754	glutathionylspermidine amidase activity
CR44_RS08060	COG0163	prenyltransferase activity
CR44_RS08065	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CR44_RS08070	COG1666	GTP binding
CR44_RS08075	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CR44_RS08080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CR44_RS08090	COG0318	PFAM AMP-dependent synthetase and ligase
CR44_RS08100	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CR44_RS08115	COG0840	transmembrane signaling receptor activity
CR44_RS08180	COG0861	Integral membrane protein TerC family
CR44_RS08185	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CR44_RS08190	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CR44_RS08190	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CR44_RS08195	COG0606	chelatase, subunit chli
CR44_RS08200	COG0242	peptide deformylase activity
CR44_RS08210	COG0740	serine-type endopeptidase activity
CR44_RS08215	COG0544	peptidyl-prolyl cis-trans isomerase activity
CR44_RS08220	COG0302	gtp cyclohydrolase
CR44_RS08225	COG1157	protein secretion by the type III secretion system
CR44_RS08230	COG1104	cysteine desulfurase activity
CR44_RS08250	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CR44_RS08255	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CR44_RS08280	COG1981	membrane
CR44_RS08290	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CR44_RS08295	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CR44_RS08300	COG0268	Binds directly to 16S ribosomal RNA
CR44_RS08305	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CR44_RS08310	COG2315	Protein conserved in bacteria
CR44_RS08320	COG0708	Exodeoxyribonuclease III
CR44_RS08325	COG2194	sulfuric ester hydrolase activity
CR44_RS08330	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CR44_RS08340	COG1971	Probably functions as a manganese efflux pump
CR44_RS08350	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CR44_RS08355	COG1121	(ABC) transporter
CR44_RS08360	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
CR44_RS08365	COG3443	Belongs to the bacterial solute-binding protein 9 family
CR44_RS08375	COG1858	cytochrome C peroxidase
CR44_RS08380	COG2200	EAL domain
CR44_RS08385	COG0288	reversible hydration of carbon dioxide
CR44_RS08390	COG0668	transmembrane transport
CR44_RS08405	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CR44_RS08410	COG0571	ribonuclease III activity
CR44_RS08425	COG0358	DNA primase activity
CR44_RS08445	COG2056	Na+-H+ antiporter family
CR44_RS08455	COG1696	Membrane protein involved in D-alanine export
CR44_RS08460	COG0129	dihydroxy-acid dehydratase activity
CR44_RS08465	COG0737	Belongs to the 5'-nucleotidase family
CR44_RS08470	COG0504	CTP synthase activity
CR44_RS08475	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CR44_RS08480	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CR44_RS08485	COG4615	Cyclic peptide transporter
CR44_RS08490	COG0748	coenzyme F420 binding
CR44_RS08500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CR44_RS08505	COG1120	ATPase activity
CR44_RS08510	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CR44_RS08535	COG1749	Flagellar hook protein flgE
CR44_RS08545	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CR44_RS08550	COG0237	dephospho-CoA kinase activity
CR44_RS08560	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CR44_RS08570	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CR44_RS08570	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CR44_RS08580	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CR44_RS08590	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CR44_RS08595	COG0233	cytoplasmic translational termination
CR44_RS08605	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CR44_RS08610	COG0670	Belongs to the BI1 family
CR44_RS08660	COG0300	oxidoreductase activity
CR44_RS08670	COG0789	Transcriptional regulator
CR44_RS08690	COG2259	Doxx family
CR44_RS08695	COG0778	Nitroreductase
CR44_RS08710	COG1187	pseudouridine synthase activity
CR44_RS08715	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CR44_RS08715	COG0517	IMP dehydrogenase activity
CR44_RS08725	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CR44_RS08730	COG2814	Major facilitator Superfamily
CR44_RS08735	COG0107	imidazoleglycerol-phosphate synthase activity
CR44_RS08745	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CR44_RS08755	COG0564	pseudouridine synthase activity
CR44_RS08760	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CR44_RS08765	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CR44_RS08770	COG0833	amino acid
CR44_RS08775	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CR44_RS08810	COG3210	domain, Protein
CR44_RS08810	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CR44_RS08810	COG3064	Membrane
CR44_RS08815	COG0513	Belongs to the DEAD box helicase family
CR44_RS08825	COG2207	Transcriptional regulator
CR44_RS08850	COG2861	carbohydrate metabolic process
CR44_RS08880	COG1028	Short-chain dehydrogenase reductase Sdr