locus-tag	class	description
CFVI03293_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CFVI03293_RS00010	COG0592	DNA-directed DNA polymerase activity
CFVI03293_RS00015	COG0187	DNA topoisomerase II activity
CFVI03293_RS00025	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CFVI03293_RS00050	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CFVI03293_RS00060	COG2814	Major facilitator Superfamily
CFVI03293_RS00065	COG1217	gtp-binding protein TYPA
CFVI03293_RS00085	COG0861	Integral membrane protein TerC family
CFVI03293_RS00090	COG3842	ATPase activity
CFVI03293_RS00140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFVI03293_RS00145	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CFVI03293_RS00155	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CFVI03293_RS00160	COG0051	transcription antitermination factor activity, RNA binding
CFVI03293_RS00165	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CFVI03293_RS00170	COG0088	Forms part of the polypeptide exit tunnel
CFVI03293_RS00175	COG0089	rRNA binding
CFVI03293_RS00180	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CFVI03293_RS00185	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CFVI03293_RS00190	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CFVI03293_RS00195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CFVI03293_RS00200	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CFVI03293_RS00210	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CFVI03293_RS00215	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CFVI03293_RS00220	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CFVI03293_RS00230	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CFVI03293_RS00235	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CFVI03293_RS00240	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CFVI03293_RS00245	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CFVI03293_RS00250	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CFVI03293_RS00255	COG0200	Binds to the 23S rRNA
CFVI03293_RS00260	COG0201	protein transport
CFVI03293_RS00265	COG0024	Methionine aminopeptidase
CFVI03293_RS00270	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CFVI03293_RS00275	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CFVI03293_RS00280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CFVI03293_RS00285	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CFVI03293_RS00290	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CFVI03293_RS00295	COG0202	RNA polymerase activity
CFVI03293_RS00300	COG0203	ribosomal protein L17
CFVI03293_RS00315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CFVI03293_RS00320	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CFVI03293_RS00330	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CFVI03293_RS00345	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CFVI03293_RS00350	COG1012	belongs to the aldehyde dehydrogenase family
CFVI03293_RS00360	COG1966	Carbon starvation protein
CFVI03293_RS00375	COG2022	thiamine diphosphate biosynthetic process
CFVI03293_RS00385	COG1739	Uncharacterized protein family UPF0029
CFVI03293_RS00395	COG0166	Belongs to the GPI family
CFVI03293_RS00400	COG0783	Belongs to the Dps family
CFVI03293_RS00405	COG2353	YceI-like domain
CFVI03293_RS00415	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CFVI03293_RS00420	COG4106	trans-aconitate 2-methyltransferase activity
CFVI03293_RS00430	COG0156	8-amino-7-oxononanoate synthase activity
CFVI03293_RS00440	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CFVI03293_RS00465	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CFVI03293_RS00490	COG3951	Flagellar rod assembly protein muramidase FlgJ
CFVI03293_RS00515	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CFVI03293_RS00525	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CFVI03293_RS00530	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CFVI03293_RS00560	COG0716	FMN binding
CFVI03293_RS00565	COG1854	S-ribosylhomocysteine lyase activity
CFVI03293_RS00570	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CFVI03293_RS00575	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CFVI03293_RS00580	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CFVI03293_RS00585	COG1840	ABC-type Fe3 transport system, periplasmic component
CFVI03293_RS00595	COG1538	Outer membrane efflux protein
CFVI03293_RS00615	COG0348	domain, Protein
CFVI03293_RS00620	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CFVI03293_RS00635	COG3260	NADH ubiquinone oxidoreductase 20
CFVI03293_RS00640	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CFVI03293_RS00645	COG3261	NADH dehydrogenase
CFVI03293_RS00645	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
CFVI03293_RS00650	COG0651	ATP synthesis coupled electron transport
CFVI03293_RS00655	COG4237	Hydrogenase 4 membrane
CFVI03293_RS00660	COG0650	Formate hydrogenlyase subunit 4
CFVI03293_RS00665	COG0651	ATP synthesis coupled electron transport
CFVI03293_RS00670	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CFVI03293_RS00685	COG1053	succinate dehydrogenase
CFVI03293_RS00685	COG3976	FMN-binding domain protein
CFVI03293_RS00705	COG0745	RESPONSE REGULATOR receiver
CFVI03293_RS00735	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CFVI03293_RS00740	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CFVI03293_RS00750	COG1620	l-lactate permease
CFVI03293_RS00755	COG1253	flavin adenine dinucleotide binding
CFVI03293_RS00790	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CFVI03293_RS00795	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CFVI03293_RS00800	COG0649	NAD binding
CFVI03293_RS00820	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CFVI03293_RS00825	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CFVI03293_RS00830	COG0839	Belongs to the complex I subunit 6 family
CFVI03293_RS00835	COG0713	ATP synthesis coupled electron transport
CFVI03293_RS00840	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CFVI03293_RS00845	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CFVI03293_RS00850	COG1007	ATP synthesis coupled electron transport
CFVI03293_RS00860	COG0310	cobalt ion transport
CFVI03293_RS00880	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CFVI03293_RS00885	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CFVI03293_RS00890	COG0475	glutathione-regulated potassium exporter activity
CFVI03293_RS00890	COG0569	domain protein
CFVI03293_RS00895	COG0372	Belongs to the citrate synthase family
CFVI03293_RS00900	COG1218	3'(2'),5'-bisphosphate nucleotidase
CFVI03293_RS00905	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CFVI03293_RS00910	COG0573	inorganic phosphate transmembrane transporter activity
CFVI03293_RS00920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CFVI03293_RS00925	COG2814	Major facilitator Superfamily
CFVI03293_RS00965	COG0314	molybdopterin synthase activity
CFVI03293_RS00980	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CFVI03293_RS01005	COG0148	phosphopyruvate hydratase activity
CFVI03293_RS01010	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CFVI03293_RS01015	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CFVI03293_RS01045	COG0575	Belongs to the CDS family
CFVI03293_RS01050	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CFVI03293_RS01055	COG0519	Catalyzes the synthesis of GMP from XMP
CFVI03293_RS01060	COG2233	PERMEase
CFVI03293_RS01075	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CFVI03293_RS01085	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CFVI03293_RS01105	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CFVI03293_RS01110	COG0602	queuosine metabolic process
CFVI03293_RS01115	COG1979	alcohol dehydrogenase
CFVI03293_RS01150	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CFVI03293_RS01155	COG1360	Flagellar Motor Protein
CFVI03293_RS01165	COG0105	UTP biosynthetic process
CFVI03293_RS01175	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CFVI03293_RS01180	COG0416	fatty acid biosynthetic process
CFVI03293_RS01185	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CFVI03293_RS01200	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CFVI03293_RS01210	COG0745	RESPONSE REGULATOR receiver
CFVI03293_RS01220	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CFVI03293_RS01235	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CFVI03293_RS01250	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CFVI03293_RS01255	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CFVI03293_RS01260	COG0450	alkyl hydroperoxide reductase
CFVI03293_RS01275	COG1570	exodeoxyribonuclease VII activity
CFVI03293_RS01300	COG1131	(ABC) transporter
CFVI03293_RS01305	COG0842	Transport permease protein
CFVI03293_RS01310	COG0842	Transport permease protein
CFVI03293_RS01320	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CFVI03293_RS01330	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CFVI03293_RS01340	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CFVI03293_RS01355	COG0019	diaminopimelate decarboxylase activity
CFVI03293_RS01370	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CFVI03293_RS01380	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CFVI03293_RS01385	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CFVI03293_RS01390	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFVI03293_RS01395	COG1120	ATPase activity
CFVI03293_RS01405	COG0811	peptide transport
CFVI03293_RS01410	COG0848	biopolymer transport protein
CFVI03293_RS01430	COG0254	rRNA binding
CFVI03293_RS01435	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CFVI03293_RS01440	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CFVI03293_RS01455	COG0436	Aminotransferase
CFVI03293_RS01460	COG0460	homoserine dehydrogenase
CFVI03293_RS01465	COG0792	nuclease activity
CFVI03293_RS01470	COG3118	belongs to the thioredoxin family
CFVI03293_RS01475	COG0492	ferredoxin-NADP+ reductase activity
CFVI03293_RS01485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CFVI03293_RS01490	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CFVI03293_RS01505	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CFVI03293_RS01505	COG0140	phosphoribosyl-ATP diphosphatase activity
CFVI03293_RS01550	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CFVI03293_RS01560	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CFVI03293_RS01565	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CFVI03293_RS01570	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CFVI03293_RS01575	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CFVI03293_RS01580	COG1077	Cell shape determining protein MreB Mrl
CFVI03293_RS01590	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CFVI03293_RS01615	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CFVI03293_RS01620	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CFVI03293_RS01630	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CFVI03293_RS01645	COG0784	Response regulator, receiver
CFVI03293_RS01645	COG0835	chemotaxis
CFVI03293_RS01650	COG2198	Histidine kinase
CFVI03293_RS01650	COG0784	Response regulator, receiver
CFVI03293_RS01650	COG0643	Histidine kinase
CFVI03293_RS01655	COG0835	chemotaxis
CFVI03293_RS01665	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CFVI03293_RS01675	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CFVI03293_RS01680	COG0193	aminoacyl-tRNA hydrolase activity
CFVI03293_RS01695	COG0709	Synthesizes selenophosphate from selenide and ATP
CFVI03293_RS01700	COG0778	Nitroreductase
CFVI03293_RS01705	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CFVI03293_RS01710	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CFVI03293_RS01715	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CFVI03293_RS01745	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CFVI03293_RS01745	COG0512	Glutamine amidotransferase of anthranilate synthase
CFVI03293_RS01755	COG0133	tryptophan synthase activity
CFVI03293_RS01770	COG1776	CheC inhibitor of MCP methylation
CFVI03293_RS01770	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CFVI03293_RS01790	COG3842	ATPase activity
CFVI03293_RS01830	COG5001	Diguanylate cyclase
CFVI03293_RS01830	COG3300	MHYT domain
CFVI03293_RS01835	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CFVI03293_RS01840	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CFVI03293_RS01860	COG0505	Belongs to the CarA family
CFVI03293_RS01870	COG3852	Histidine kinase
CFVI03293_RS01875	COG0745	RESPONSE REGULATOR receiver
CFVI03293_RS01880	COG3278	Belongs to the heme-copper respiratory oxidase family
CFVI03293_RS01920	COG1074	ATP-dependent DNA helicase activity
CFVI03293_RS01925	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CFVI03293_RS01930	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CFVI03293_RS01935	COG2885	chlorophyll binding
CFVI03293_RS01940	COG0668	transmembrane transport
CFVI03293_RS01950	COG1013	pyruvate-flavodoxin oxidoreductase activity
CFVI03293_RS01950	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CFVI03293_RS01950	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CFVI03293_RS01950	COG0674	pyruvate-flavodoxin oxidoreductase activity
CFVI03293_RS01970	COG4773	Receptor
CFVI03293_RS01975	COG4773	Receptor
CFVI03293_RS01985	COG0683	leucine binding
CFVI03293_RS01990	COG0559	Belongs to the binding-protein-dependent transport system permease family
CFVI03293_RS02010	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CFVI03293_RS02010	COG1333	cytochrome c biogenesis protein
CFVI03293_RS02020	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CFVI03293_RS02025	COG2046	Belongs to the sulfate adenylyltransferase family
CFVI03293_RS02035	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CFVI03293_RS02035	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CFVI03293_RS02040	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CFVI03293_RS02045	COG0489	protein tyrosine kinase activity
CFVI03293_RS02050	COG2171	N-acyltransferase activity
CFVI03293_RS02055	COG0488	(ABC) transporter
CFVI03293_RS02060	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CFVI03293_RS02065	COG1053	succinate dehydrogenase
CFVI03293_RS02090	COG2217	Heavy metal translocating P-type atpase
CFVI03293_RS02105	COG0814	amino acid
CFVI03293_RS02110	COG0217	transcriptional regulatory protein
CFVI03293_RS02115	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CFVI03293_RS02120	COG1301	dicarboxylic acid transport
CFVI03293_RS02125	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CFVI03293_RS02130	COG0243	molybdopterin cofactor binding
CFVI03293_RS02150	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CFVI03293_RS02155	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CFVI03293_RS02170	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CFVI03293_RS02185	COG4263	nitrous-oxide reductase activity
CFVI03293_RS02215	COG0437	4 iron, 4 sulfur cluster binding
CFVI03293_RS02230	COG0348	domain, Protein
CFVI03293_RS02235	COG3842	ATPase activity
CFVI03293_RS02255	COG0642	Histidine kinase
CFVI03293_RS02260	COG0745	RESPONSE REGULATOR receiver
CFVI03293_RS02300	COG1373	ATPase (AAA superfamily
CFVI03293_RS02310	COG3041	Addiction module toxin RelE StbE family
CFVI03293_RS02355	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CFVI03293_RS02365	COG2255	four-way junction helicase activity
CFVI03293_RS02370	COG0628	permease
CFVI03293_RS02380	COG1127	ABC transporter
CFVI03293_RS02395	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CFVI03293_RS02475	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CFVI03293_RS02480	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CFVI03293_RS02485	COG0552	protein localization to endoplasmic reticulum
CFVI03293_RS02490	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CFVI03293_RS02500	COG1418	mRNA catabolic process
CFVI03293_RS02550	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CFVI03293_RS02555	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CFVI03293_RS02560	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CFVI03293_RS02565	COG0191	fructose-bisphosphate aldolase activity
CFVI03293_RS02585	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CFVI03293_RS02595	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CFVI03293_RS02600	COG4786	Flagellar basal body rod
CFVI03293_RS02610	COG0672	)-iron permease
CFVI03293_RS02635	COG1136	(ABC) transporter
CFVI03293_RS02645	COG2957	Belongs to the agmatine deiminase family
CFVI03293_RS02660	COG0786	glutamate:sodium symporter activity
CFVI03293_RS02670	COG0534	Mate efflux family protein
CFVI03293_RS02675	COG2205	protein histidine kinase activity
CFVI03293_RS02680	COG0745	RESPONSE REGULATOR receiver
CFVI03293_RS02690	COG0488	(ABC) transporter
CFVI03293_RS02695	COG0733	neurotransmitter:sodium symporter activity
CFVI03293_RS02700	COG0501	Belongs to the peptidase M48B family
CFVI03293_RS02705	COG2890	protein-(glutamine-N5) methyltransferase activity
CFVI03293_RS02720	COG0824	Thioesterase
CFVI03293_RS02740	COG0004	ammonium transporteR
CFVI03293_RS02745	COG0347	Belongs to the P(II) protein family
CFVI03293_RS02750	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CFVI03293_RS02755	COG0594	ribonuclease P activity
CFVI03293_RS02760	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CFVI03293_RS02765	COG0706	membrane insertase activity
CFVI03293_RS02775	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CFVI03293_RS02780	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CFVI03293_RS02785	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CFVI03293_RS02790	COG0138	bifunctional purine biosynthesis protein purh
CFVI03293_RS02805	COG2151	metal-sulfur cluster biosynthetic enzyme
CFVI03293_RS02810	COG0840	transmembrane signaling receptor activity
CFVI03293_RS02835	COG0275	rRNA processing
CFVI03293_RS02845	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CFVI03293_RS02850	COG0849	cell division
CFVI03293_RS02855	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CFVI03293_RS02865	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CFVI03293_RS02875	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CFVI03293_RS02880	COG0653	protein targeting
CFVI03293_RS02885	COG4591	ABC-type transport system involved in lipoprotein release permease component
CFVI03293_RS02900	COG2814	Major facilitator Superfamily
CFVI03293_RS02910	COG2252	PERMEase
CFVI03293_RS02915	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CFVI03293_RS02920	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CFVI03293_RS02925	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CFVI03293_RS02935	COG0425	Belongs to the sulfur carrier protein TusA family
CFVI03293_RS02940	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CFVI03293_RS02945	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CFVI03293_RS03030	COG1546	Belongs to the CinA family
CFVI03293_RS03030	COG1058	Belongs to the CinA family
CFVI03293_RS03040	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CFVI03293_RS03045	COG0154	amidase activity
CFVI03293_RS03050	COG0517	IMP dehydrogenase activity
CFVI03293_RS03050	COG0516	GMP reductase activity
CFVI03293_RS03055	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CFVI03293_RS03080	COG1902	pentaerythritol trinitrate reductase activity
CFVI03293_RS03085	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CFVI03293_RS03090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CFVI03293_RS03110	COG1193	negative regulation of DNA recombination
CFVI03293_RS03115	COG3287	FIST C domain
CFVI03293_RS03115	COG2200	EAL domain
CFVI03293_RS03115	COG2199	diguanylate cyclase activity
CFVI03293_RS03125	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CFVI03293_RS03130	COG0579	oxidoreductase
CFVI03293_RS03145	COG0612	Peptidase, M16
CFVI03293_RS03150	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CFVI03293_RS03155	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CFVI03293_RS03160	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CFVI03293_RS03165	COG0492	ferredoxin-NADP+ reductase activity
CFVI03293_RS03175	COG2813	Specifically methylates the guanine in position
CFVI03293_RS03180	COG0727	PFAM Uncharacterised protein family (UPF0153)
CFVI03293_RS03190	COG0134	indole-3-glycerol-phosphate synthase activity
CFVI03293_RS03200	COG3022	response to hydroperoxide
CFVI03293_RS03230	COG0439	Biotin carboxylase
CFVI03293_RS03250	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CFVI03293_RS03255	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CFVI03293_RS03265	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CFVI03293_RS03270	COG1196	nuclear chromosome segregation
CFVI03293_RS03270	COG1674	ftsk spoiiie
CFVI03293_RS03285	COG0142	geranyltranstransferase activity
CFVI03293_RS03290	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CFVI03293_RS03295	COG0442	prolyl-tRNA aminoacylation
CFVI03293_RS03305	COG0181	hydroxymethylbilane synthase activity
CFVI03293_RS03310	COG1295	ribonuclease BN
CFVI03293_RS03315	COG0277	FAD linked oxidase domain protein
CFVI03293_RS03325	COG0739	heme binding
CFVI03293_RS03330	COG2239	Acts as a magnesium transporter
CFVI03293_RS03345	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CFVI03293_RS03350	COG0459	protein refolding
CFVI03293_RS03355	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CFVI03293_RS03365	COG1677	Flagellar hook-basal body complex protein FliE
CFVI03293_RS03375	COG1815	bacterial-type flagellum-dependent cell motility
CFVI03293_RS03390	COG0542	response to heat
CFVI03293_RS03395	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CFVI03293_RS03405	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CFVI03293_RS03425	COG0210	DNA helicase
CFVI03293_RS03445	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CFVI03293_RS03450	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CFVI03293_RS03460	COG1121	(ABC) transporter
CFVI03293_RS03465	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CFVI03293_RS03470	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CFVI03293_RS03475	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CFVI03293_RS03480	COG1862	Preprotein translocase
CFVI03293_RS03485	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFVI03293_RS03490	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CFVI03293_RS03500	COG0495	leucyl-tRNA aminoacylation
CFVI03293_RS03515	COG0285	dihydrofolate synthase activity
CFVI03293_RS03520	COG0739	heme binding
CFVI03293_RS03530	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CFVI03293_RS03555	COG1832	CoA-binding protein
CFVI03293_RS03560	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CFVI03293_RS03565	COG3210	domain, Protein
CFVI03293_RS03565	COG3064	Membrane
CFVI03293_RS03565	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CFVI03293_RS03580	COG0101	tRNA pseudouridine synthase activity
CFVI03293_RS03590	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CFVI03293_RS03595	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CFVI03293_RS03610	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CFVI03293_RS03615	COG1338	Plays a role in the flagellum-specific transport system
CFVI03293_RS03635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CFVI03293_RS03640	COG0577	efflux transmembrane transporter activity
CFVI03293_RS03640	COG1136	(ABC) transporter
CFVI03293_RS03645	COG1538	Outer membrane efflux protein
CFVI03293_RS03655	COG0642	Histidine kinase
CFVI03293_RS03660	COG0745	RESPONSE REGULATOR receiver
CFVI03293_RS03670	COG0484	heat shock protein binding
CFVI03293_RS03675	COG0789	Transcriptional regulator
CFVI03293_RS03680	COG0475	glutathione-regulated potassium exporter activity
CFVI03293_RS03680	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CFVI03293_RS03710	COG0066	3-isopropylmalate dehydratase activity
CFVI03293_RS03715	COG0473	3-isopropylmalate dehydrogenase activity
CFVI03293_RS03730	COG0617	tRNA 3'-terminal CCA addition
CFVI03293_RS03735	COG0248	Ppx GppA phosphatase
CFVI03293_RS03755	COG1459	type II secretion system
CFVI03293_RS03795	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CFVI03293_RS03800	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CFVI03293_RS03805	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CFVI03293_RS03810	COG0359	binds to the 23S rRNA
CFVI03293_RS03815	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CFVI03293_RS03815	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CFVI03293_RS03825	COG1049	propionate catabolic process, 2-methylcitrate cycle
CFVI03293_RS03840	COG2346	COG2346, Truncated hemoglobins
CFVI03293_RS03875	COG2911	Protein conserved in bacteria
CFVI03293_RS03880	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CFVI03293_RS03890	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CFVI03293_RS03895	COG0305	Participates in initiation and elongation during chromosome replication
CFVI03293_RS03905	COG0343	queuine tRNA-ribosyltransferase activity
CFVI03293_RS03920	COG4221	oxidoreductase activity
CFVI03293_RS03925	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CFVI03293_RS03940	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CFVI03293_RS03950	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CFVI03293_RS03960	COG0351	phosphomethylpyrimidine kinase
CFVI03293_RS03960	COG0352	thiamine-phosphate diphosphorylase activity
CFVI03293_RS03965	COG2011	ABC-type metal ion transport system permease component
CFVI03293_RS03970	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CFVI03293_RS03980	COG0114	fumarate hydratase activity
CFVI03293_RS04000	COG0500	methyltransferase
CFVI03293_RS04010	COG0326	Molecular chaperone. Has ATPase activity
CFVI03293_RS04035	COG3021	interspecies interaction between organisms
CFVI03293_RS04045	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CFVI03293_RS04050	COG0204	Acyl-transferase
CFVI03293_RS04060	COG0047	phosphoribosylformylglycinamidine synthase activity
CFVI03293_RS04065	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CFVI03293_RS04070	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CFVI03293_RS04075	COG0793	Belongs to the peptidase S41A family
CFVI03293_RS04080	COG0542	response to heat
CFVI03293_RS04100	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CFVI03293_RS04105	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
CFVI03293_RS04110	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CFVI03293_RS04115	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CFVI03293_RS04120	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CFVI03293_RS04130	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CFVI03293_RS04135	COG0298	carbon dioxide binding
CFVI03293_RS04140	COG0409	Hydrogenase expression formation protein
CFVI03293_RS04145	COG0309	Hydrogenase expression formation protein (HypE)
CFVI03293_RS04165	COG2860	membrane
CFVI03293_RS04170	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CFVI03293_RS04175	COG0179	Fumarylacetoacetate (FAA) hydrolase
CFVI03293_RS04180	COG1580	Controls the rotational direction of flagella during chemotaxis
CFVI03293_RS04185	COG0736	holo-[acyl-carrier-protein] synthase activity
CFVI03293_RS04195	COG1959	2 iron, 2 sulfur cluster binding
CFVI03293_RS04205	COG1151	hydroxylamine reductase activity
CFVI03293_RS04235	COG0039	L-malate dehydrogenase activity
CFVI03293_RS04240	COG0045	succinate-CoA ligase (ADP-forming) activity
CFVI03293_RS04245	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CFVI03293_RS04255	COG0674	pyruvate-flavodoxin oxidoreductase activity
CFVI03293_RS04255	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CFVI03293_RS04260	COG3962	Belongs to the TPP enzyme family
CFVI03293_RS04290	COG0716	FMN binding
CFVI03293_RS04300	COG1442	glycosyl transferase family 8
CFVI03293_RS04300	COG1216	Glycosyl transferase, family 2
CFVI03293_RS04305	COG0436	Aminotransferase
CFVI03293_RS04310	COG1045	serine acetyltransferase
CFVI03293_RS04315	COG1166	arginine decarboxylase activity
CFVI03293_RS04320	COG0124	histidyl-tRNA synthetase
CFVI03293_RS04325	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CFVI03293_RS04330	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CFVI03293_RS04345	COG0303	'Molybdopterin
CFVI03293_RS04350	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CFVI03293_RS04360	COG1556	Lactate utilization protein
CFVI03293_RS04365	COG1139	Iron-sulfur cluster binding protein
CFVI03293_RS04370	COG0247	lactate metabolic process
CFVI03293_RS04380	COG2833	Protein of unknown function (DUF455)
CFVI03293_RS04385	COG0588	phosphoglycerate mutase activity
CFVI03293_RS04390	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CFVI03293_RS04390	COG4797	methyltransferase
CFVI03293_RS04400	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CFVI03293_RS04410	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CFVI03293_RS04430	COG0556	nucleotide-excision repair
CFVI03293_RS04465	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CFVI03293_RS04475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CFVI03293_RS04480	COG0750	zinc metalloprotease
CFVI03293_RS04485	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CFVI03293_RS04490	COG0521	Mo-molybdopterin cofactor biosynthetic process
CFVI03293_RS04495	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CFVI03293_RS04500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CFVI03293_RS04510	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CFVI03293_RS04515	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CFVI03293_RS04525	COG0802	atpase or kinase
CFVI03293_RS04530	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CFVI03293_RS04540	COG0848	biopolymer transport protein
CFVI03293_RS04545	COG0811	peptide transport
CFVI03293_RS04550	COG0776	regulation of translation
CFVI03293_RS04555	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CFVI03293_RS04560	COG0772	Belongs to the SEDS family
CFVI03293_RS04565	COG0582	viral genome integration into host DNA
CFVI03293_RS04570	COG0137	argininosuccinate synthase activity
CFVI03293_RS04575	COG0642	Histidine kinase
CFVI03293_RS04580	COG0745	RESPONSE REGULATOR receiver
CFVI03293_RS04590	COG0739	heme binding
CFVI03293_RS04625	COG2217	Heavy metal translocating P-type atpase
CFVI03293_RS04650	COG0751	glycine-tRNA ligase activity
CFVI03293_RS04665	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CFVI03293_RS04670	COG0788	formyltetrahydrofolate deformylase activity
CFVI03293_RS04675	COG0157	Belongs to the NadC ModD family
CFVI03293_RS04680	COG0586	Pfam SNARE associated Golgi protein
CFVI03293_RS04695	COG0440	acetolactate synthase activity
CFVI03293_RS04700	COG0028	Belongs to the TPP enzyme family
CFVI03293_RS04715	COG0280	phosphate acetyltransferase
CFVI03293_RS04720	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CFVI03293_RS04725	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CFVI03293_RS04740	COG1181	Belongs to the D-alanine--D-alanine ligase family
CFVI03293_RS04745	COG0632	four-way junction helicase activity
CFVI03293_RS04755	COG2201	protein-glutamate methylesterase activity
CFVI03293_RS04760	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CFVI03293_RS04775	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CFVI03293_RS04800	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFVI03293_RS04800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CFVI03293_RS04810	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CFVI03293_RS04825	COG0513	Belongs to the DEAD box helicase family
CFVI03293_RS04830	COG0728	peptidoglycan biosynthetic process
CFVI03293_RS04835	COG0215	cysteine-tRNA ligase activity
CFVI03293_RS04840	COG1132	(ABC) transporter
CFVI03293_RS04845	COG0167	dihydroorotate dehydrogenase activity
CFVI03293_RS04850	COG0612	Peptidase, M16
CFVI03293_RS04855	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFVI03293_RS04860	COG1028	Short-chain dehydrogenase reductase Sdr
CFVI03293_RS04865	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CFVI03293_RS04870	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFVI03293_RS04875	COG0765	amino acid transport
CFVI03293_RS04880	COG1126	abc transporter atp-binding protein
CFVI03293_RS04885	COG2962	Rard protein
CFVI03293_RS04895	COG1472	Belongs to the glycosyl hydrolase 3 family
CFVI03293_RS04905	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CFVI03293_RS04920	COG0356	it plays a direct role in the translocation of protons across the membrane
CFVI03293_RS04925	COG0730	response to heat
CFVI03293_RS04935	COG3263	regulation of cellular component size
CFVI03293_RS04955	COG0252	asparaginase activity
CFVI03293_RS04960	COG1322	Protein conserved in bacteria
CFVI03293_RS04970	COG2824	Alkylphosphonate utilization operon protein PhnA
CFVI03293_RS04975	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CFVI03293_RS04985	COG0424	maF-like protein
CFVI03293_RS05000	COG0335	large ribosomal subunit rRNA binding
CFVI03293_RS05005	COG0336	Belongs to the RNA methyltransferase TrmD family
CFVI03293_RS05010	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CFVI03293_RS05020	COG0228	four-way junction DNA binding
CFVI03293_RS05025	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CFVI03293_RS05030	COG0471	metal ion transport
CFVI03293_RS05040	COG0564	pseudouridine synthase activity
CFVI03293_RS05045	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CFVI03293_RS05045	COG1519	Transferase
CFVI03293_RS05055	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CFVI03293_RS05060	COG0752	glycyl-tRNA synthetase alpha subunit
CFVI03293_RS05070	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CFVI03293_RS05075	COG0826	peptidase U32
CFVI03293_RS05090	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CFVI03293_RS05095	COG0174	glutamine synthetase
CFVI03293_RS05110	COG0753	catalase activity
CFVI03293_RS05120	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CFVI03293_RS05125	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CFVI03293_RS05135	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CFVI03293_RS05140	COG2721	sulfolactate sulfo-lyase activity
CFVI03293_RS05150	COG0738	Major facilitator superfamily
CFVI03293_RS05160	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CFVI03293_RS05190	COG0500	methyltransferase
CFVI03293_RS05195	COG2050	protein possibly involved in aromatic compounds catabolism
CFVI03293_RS05195	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CFVI03293_RS05200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CFVI03293_RS05205	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CFVI03293_RS05215	COG1663	tetraacyldisaccharide 4'-kinase activity
CFVI03293_RS05220	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CFVI03293_RS05225	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CFVI03293_RS05230	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CFVI03293_RS05240	COG3706	GGDEF domain
CFVI03293_RS05450	COG2842	Transposition protein
CFVI03293_RS05475	COG0443	Heat shock 70 kDa protein
CFVI03293_RS05480	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CFVI03293_RS05485	COG1420	regulation of RNA biosynthetic process
CFVI03293_RS05510	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CFVI03293_RS05515	COG1959	2 iron, 2 sulfur cluster binding
CFVI03293_RS05520	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CFVI03293_RS05525	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CFVI03293_RS05530	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CFVI03293_RS05540	COG3842	ATPase activity
CFVI03293_RS05575	COG2226	methyltransferase
CFVI03293_RS05580	COG0196	riboflavin kinase activity
CFVI03293_RS05590	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CFVI03293_RS05595	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CFVI03293_RS05600	COG0470	DNA polymerase III
CFVI03293_RS05610	COG0527	aspartate kinase activity
CFVI03293_RS05615	COG0494	nUDIX hydrolase
CFVI03293_RS05620	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CFVI03293_RS05625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CFVI03293_RS05630	COG0805	protein transport
CFVI03293_RS05635	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CFVI03293_RS05650	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CFVI03293_RS05655	COG0758	DNA mediated transformation
CFVI03293_RS05660	COG2861	carbohydrate metabolic process
CFVI03293_RS05665	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CFVI03293_RS05675	COG0557	exoribonuclease II activity
CFVI03293_RS05685	COG0360	Binds together with S18 to 16S ribosomal RNA
CFVI03293_RS05690	COG0629	single-stranded DNA binding
CFVI03293_RS05695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CFVI03293_RS05700	COG0484	heat shock protein binding
CFVI03293_RS05705	COG0745	RESPONSE REGULATOR receiver
CFVI03293_RS05710	COG0642	Histidine kinase
CFVI03293_RS05720	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CFVI03293_RS05735	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CFVI03293_RS05740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CFVI03293_RS05760	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CFVI03293_RS05780	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CFVI03293_RS05785	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CFVI03293_RS05790	COG1114	Component of the transport system for branched-chain amino acids
CFVI03293_RS05795	COG1408	metallophosphoesterase
CFVI03293_RS05800	COG0688	phosphatidylethanolamine metabolic process
CFVI03293_RS05820	COG3043	anaerobic respiration
CFVI03293_RS05825	COG0348	domain, Protein
CFVI03293_RS05830	COG0437	4 iron, 4 sulfur cluster binding
CFVI03293_RS05835	COG0243	molybdopterin cofactor binding
CFVI03293_RS05840	COG0765	amino acid transport
CFVI03293_RS05845	COG0765	amino acid transport
CFVI03293_RS05850	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CFVI03293_RS05855	COG1126	abc transporter atp-binding protein
CFVI03293_RS05860	COG0012	GTP binding
CFVI03293_RS05865	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CFVI03293_RS05875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CFVI03293_RS05885	COG0698	ribose 5-phosphate isomerase
CFVI03293_RS05890	COG1994	Peptidase M50
CFVI03293_RS05895	COG0681	Belongs to the peptidase S26 family
CFVI03293_RS05900	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CFVI03293_RS05910	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CFVI03293_RS05935	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CFVI03293_RS05975	COG0131	Imidazoleglycerol-phosphate dehydratase
CFVI03293_RS05980	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CFVI03293_RS05985	COG0791	NLP P60 protein
CFVI03293_RS05985	COG1388	LysM domain
CFVI03293_RS05990	COG0084	hydrolase, TatD family'
CFVI03293_RS06000	COG0497	DNA recombination
CFVI03293_RS06010	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CFVI03293_RS06015	COG0563	adenylate kinase activity
CFVI03293_RS06020	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CFVI03293_RS06025	COG0519	Catalyzes the synthesis of GMP from XMP
CFVI03293_RS06035	COG1120	ATPase activity
CFVI03293_RS06040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFVI03293_RS06045	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CFVI03293_RS06060	COG4771	TonB-dependent receptor
CFVI03293_RS06070	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CFVI03293_RS06070	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CFVI03293_RS06075	COG0860	N-Acetylmuramoyl-L-alanine amidase
CFVI03293_RS06080	COG0516	GMP reductase activity
CFVI03293_RS06085	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CFVI03293_RS06095	COG1758	RNA polymerase activity
CFVI03293_RS06100	COG0528	UMP kinase activity
CFVI03293_RS06115	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CFVI03293_RS06120	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CFVI03293_RS06130	COG0564	pseudouridine synthase activity
CFVI03293_RS06135	COG0772	Belongs to the SEDS family
CFVI03293_RS06140	COG1999	signal sequence binding
CFVI03293_RS06145	COG0840	transmembrane signaling receptor activity
CFVI03293_RS06150	COG1733	regulation of RNA biosynthetic process
CFVI03293_RS06155	COG2910	NAD(P)H-binding
CFVI03293_RS06265	COG3177	Filamentation induced by cAMP protein fic
CFVI03293_RS06325	COG0741	lytic transglycosylase activity
CFVI03293_RS06335	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CFVI03293_RS06380	COG3504	Conjugal transfer protein
CFVI03293_RS06395	COG3736	Type IV secretory pathway, component VirB8
CFVI03293_RS06425	COG0582	viral genome integration into host DNA
CFVI03293_RS06440	COG0765	amino acid transport
CFVI03293_RS06445	COG1126	abc transporter atp-binding protein
CFVI03293_RS06460	COG0352	thiamine-phosphate diphosphorylase activity
CFVI03293_RS06465	COG1968	undecaprenyl-diphosphatase activity
CFVI03293_RS06480	COG0642	Histidine kinase
CFVI03293_RS06485	COG0587	DNA-directed DNA polymerase activity
CFVI03293_RS06490	COG0724	RNA recognition motif
CFVI03293_RS06495	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CFVI03293_RS06495	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
CFVI03293_RS06495	COG0506	proline dehydrogenase activity
CFVI03293_RS06505	COG3005	denitrification pathway
CFVI03293_RS06510	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CFVI03293_RS06520	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CFVI03293_RS06525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CFVI03293_RS06535	COG0539	negative regulation of cytoplasmic translation
CFVI03293_RS06535	COG1185	polyribonucleotide nucleotidyltransferase activity
CFVI03293_RS06540	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CFVI03293_RS06545	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CFVI03293_RS06555	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CFVI03293_RS06560	COG0537	adenosine 5'-monophosphoramidase activity
CFVI03293_RS06570	COG1185	polyribonucleotide nucleotidyltransferase activity
CFVI03293_RS06605	COG0519	Catalyzes the synthesis of GMP from XMP
CFVI03293_RS06630	COG2201	protein-glutamate methylesterase activity
CFVI03293_RS06635	COG3787	Belongs to the UPF0306 family
CFVI03293_RS06670	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CFVI03293_RS06675	COG1607	acyl-coa hydrolase
CFVI03293_RS06690	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CFVI03293_RS06700	COG1742	UPF0060 membrane protein
CFVI03293_RS06710	COG2207	Transcriptional regulator
CFVI03293_RS06715	COG1979	alcohol dehydrogenase
CFVI03293_RS06740	COG0733	neurotransmitter:sodium symporter activity
CFVI03293_RS06745	COG0511	ligase activity, forming carbon-carbon bonds
CFVI03293_RS06745	COG5016	pyruvate
CFVI03293_RS06750	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CFVI03293_RS06755	COG0165	Argininosuccinate lyase
CFVI03293_RS06765	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CFVI03293_RS06770	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
CFVI03293_RS06790	COG0840	transmembrane signaling receptor activity
CFVI03293_RS06805	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CFVI03293_RS06810	COG0049	tRNA binding
CFVI03293_RS06815	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CFVI03293_RS06820	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CFVI03293_RS06825	COG0085	RNA polymerase activity
CFVI03293_RS06830	COG0222	ribosome binding
CFVI03293_RS06835	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CFVI03293_RS06840	COG0081	regulation of translation
CFVI03293_RS06845	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CFVI03293_RS06850	COG0250	Participates in transcription elongation, termination and antitermination
CFVI03293_RS06865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CFVI03293_RS06870	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CFVI03293_RS06905	COG0284	orotidine-5'-phosphate decarboxylase activity
CFVI03293_RS06910	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CFVI03293_RS06915	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CFVI03293_RS06930	COG2877	3-deoxy-8-phosphooctulonate synthase activity
CFVI03293_RS06935	COG0697	spore germination
CFVI03293_RS06940	COG1160	GTP binding
CFVI03293_RS06955	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CFVI03293_RS06965	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CFVI03293_RS06970	COG1183	phosphatidylcholine synthase activity
CFVI03293_RS06980	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CFVI03293_RS06985	COG2264	protein methyltransferase activity
CFVI03293_RS06990	COG0745	RESPONSE REGULATOR receiver
CFVI03293_RS06995	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CFVI03293_RS07000	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CFVI03293_RS07010	COG1086	Polysaccharide biosynthesis protein
CFVI03293_RS07015	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CFVI03293_RS07020	COG2249	NAD(P)H dehydrogenase (quinone) activity
CFVI03293_RS07035	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CFVI03293_RS07045	COG1028	Short-chain dehydrogenase reductase Sdr
CFVI03293_RS07050	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CFVI03293_RS07055	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CFVI03293_RS07060	COG0825	malonyl-CoA metabolic process
CFVI03293_RS07070	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CFVI03293_RS07080	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CFVI03293_RS07085	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CFVI03293_RS07090	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CFVI03293_RS07115	COG2121	Domain of unknown function (DUF374)
CFVI03293_RS07120	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CFVI03293_RS07130	COG0195	Participates in both transcription termination and antitermination
CFVI03293_RS07140	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CFVI03293_RS07145	COG0438	transferase activity, transferring glycosyl groups
CFVI03293_RS07155	COG0438	transferase activity, transferring glycosyl groups
CFVI03293_RS07160	COG0438	transferase activity, transferring glycosyl groups
CFVI03293_RS07165	COG0438	transferase activity, transferring glycosyl groups
CFVI03293_RS07170	COG2244	polysaccharide biosynthetic process
CFVI03293_RS07180	COG0463	Glycosyl transferase, family 2
CFVI03293_RS07190	COG2246	polysaccharide biosynthetic process
CFVI03293_RS07210	COG1793	dna ligase
CFVI03293_RS07220	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
CFVI03293_RS07240	COG0463	Glycosyl transferase, family 2
CFVI03293_RS07245	COG0859	PFAM glycosyl transferase family 9
CFVI03293_RS07250	COG0726	polysaccharide deacetylase
CFVI03293_RS07265	COG0859	PFAM glycosyl transferase family 9
CFVI03293_RS07275	COG0859	PFAM glycosyl transferase family 9
CFVI03293_RS07290	COG0859	PFAM glycosyl transferase family 9
CFVI03293_RS07295	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CFVI03293_RS07300	COG1794	racemase activity, acting on amino acids and derivatives
CFVI03293_RS07305	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CFVI03293_RS07305	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CFVI03293_RS07310	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CFVI03293_RS07315	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CFVI03293_RS07350	COG2217	Heavy metal translocating P-type atpase
CFVI03293_RS07355	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CFVI03293_RS07380	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CFVI03293_RS07385	COG0149	triose-phosphate isomerase activity
CFVI03293_RS07390	COG0126	phosphoglycerate kinase activity
CFVI03293_RS07395	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CFVI03293_RS07400	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CFVI03293_RS07405	COG0799	negative regulation of ribosome biogenesis
CFVI03293_RS07410	COG2855	membrane
CFVI03293_RS07415	COG0583	DNA-binding transcription factor activity
CFVI03293_RS07420	COG0018	arginyl-trna synthetase
CFVI03293_RS07425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CFVI03293_RS07440	COG1684	flagellar biosynthetic protein fliR
CFVI03293_RS07445	COG4774	siderophore transport
CFVI03293_RS07450	COG1136	(ABC) transporter
CFVI03293_RS07455	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CFVI03293_RS07460	COG0052	Belongs to the universal ribosomal protein uS2 family
CFVI03293_RS07470	COG1496	oxidoreductase activity
CFVI03293_RS07480	COG0445	tRNA wobble uridine modification
CFVI03293_RS07485	COG0723	plastoquinol--plastocyanin reductase activity
CFVI03293_RS07520	COG0731	radical SAM domain protein
CFVI03293_RS07525	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CFVI03293_RS07535	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CFVI03293_RS07540	COG2204	response regulator
CFVI03293_RS07575	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CFVI03293_RS07600	COG1942	4-Oxalocrotonate Tautomerase
CFVI03293_RS07605	COG0481	GTPase activity
CFVI03293_RS07610	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CFVI03293_RS07615	COG0540	Belongs to the ATCase OTCase family
CFVI03293_RS07640	COG0482	sulfurtransferase activity
CFVI03293_RS07665	COG0493	'glutamate synthase
CFVI03293_RS07670	COG0067	glutamate synthase
CFVI03293_RS07670	COG0070	glutamate synthase
CFVI03293_RS07670	COG0069	glutamate synthase activity
CFVI03293_RS07675	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CFVI03293_RS07675	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CFVI03293_RS07690	COG0779	Required for maturation of 30S ribosomal subunits
CFVI03293_RS07700	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CFVI03293_RS07710	COG0083	homoserine kinase activity
CFVI03293_RS07720	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CFVI03293_RS07725	COG0384	phenazine biosynthesis protein PhzF
CFVI03293_RS07735	COG0287	Prephenate dehydrogenase
CFVI03293_RS07740	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CFVI03293_RS07745	COG2258	MOSC domain
CFVI03293_RS07750	COG0616	signal peptide processing
CFVI03293_RS07755	COG0402	S-adenosylhomocysteine deaminase activity
CFVI03293_RS07760	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CFVI03293_RS07765	COG0006	proline dipeptidase activity
CFVI03293_RS07770	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CFVI03293_RS07775	COG1419	protein localization to endoplasmic reticulum
CFVI03293_RS07780	COG0455	bacterial-type flagellum organization
CFVI03293_RS07795	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CFVI03293_RS07800	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CFVI03293_RS07800	COG1776	CheC inhibitor of MCP methylation
CFVI03293_RS07805	COG0037	tRNA processing
CFVI03293_RS07810	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CFVI03293_RS07815	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CFVI03293_RS07820	COG1047	Peptidyl-prolyl cis-trans
CFVI03293_RS07835	COG0823	Involved in the tonB-independent uptake of proteins
CFVI03293_RS07845	COG0848	biopolymer transport protein
CFVI03293_RS07850	COG0811	peptide transport
CFVI03293_RS07855	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CFVI03293_RS07860	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CFVI03293_RS07865	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CFVI03293_RS07870	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CFVI03293_RS07875	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CFVI03293_RS07880	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CFVI03293_RS07885	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CFVI03293_RS07890	COG1475	DNA binding
CFVI03293_RS07895	COG1192	Involved in chromosome partitioning
CFVI03293_RS07900	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CFVI03293_RS07900	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CFVI03293_RS07905	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CFVI03293_RS07915	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CFVI03293_RS07920	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CFVI03293_RS07925	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CFVI03293_RS07930	COG1858	cytochrome C peroxidase
CFVI03293_RS07950	COG1083	cytidylyl-transferase
CFVI03293_RS07965	COG1921	L-seryl-tRNASec selenium transferase activity
CFVI03293_RS07985	COG0243	molybdopterin cofactor binding
CFVI03293_RS07990	COG0243	molybdopterin cofactor binding
CFVI03293_RS07990	COG3383	formate dehydrogenase (NAD+) activity
CFVI03293_RS07995	COG0437	4 iron, 4 sulfur cluster binding
CFVI03293_RS08010	COG2089	acid synthase
CFVI03293_RS08015	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CFVI03293_RS08020	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CFVI03293_RS08025	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CFVI03293_RS08030	COG0280	phosphate acetyltransferase
CFVI03293_RS08030	COG0281	malic enzyme
CFVI03293_RS08040	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CFVI03293_RS08060	COG0717	Belongs to the dCTP deaminase family
CFVI03293_RS08065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CFVI03293_RS08075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CFVI03293_RS08085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CFVI03293_RS08095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CFVI03293_RS08100	COG0113	porphobilinogen synthase activity
CFVI03293_RS08105	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CFVI03293_RS08110	COG0357	Ribosomal RNA small subunit methyltransferase G
CFVI03293_RS08125	COG0501	Belongs to the peptidase M48B family
CFVI03293_RS08170	COG3959	Transketolase, thiamine diphosphate binding domain
CFVI03293_RS08210	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CFVI03293_RS08215	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CFVI03293_RS08235	COG0859	PFAM glycosyl transferase family 9
CFVI03293_RS08250	COG0367	asparagine synthase
CFVI03293_RS08255	COG0438	transferase activity, transferring glycosyl groups
CFVI03293_RS08280	COG0367	asparagine synthase
CFVI03293_RS08330	COG0529	Catalyzes the synthesis of activated sulfate
CFVI03293_RS08345	COG0574	Belongs to the PEP-utilizing enzyme family
CFVI03293_RS08345	COG3848	Pyruvate phosphate dikinase
CFVI03293_RS08350	COG0519	Catalyzes the synthesis of GMP from XMP
CFVI03293_RS08350	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CFVI03293_RS08355	COG1213	nucleotidyl transferase
CFVI03293_RS08360	COG1086	Polysaccharide biosynthesis protein
CFVI03293_RS08365	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CFVI03293_RS08370	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CFVI03293_RS08375	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CFVI03293_RS08380	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CFVI03293_RS08380	COG4797	methyltransferase
CFVI03293_RS08395	COG0628	permease
CFVI03293_RS08400	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CFVI03293_RS08405	COG0569	domain protein
CFVI03293_RS08410	COG1027	Aspartate ammonia-lyase
CFVI03293_RS08415	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CFVI03293_RS08435	COG0811	peptide transport
CFVI03293_RS08440	COG0848	biopolymer transport protein
CFVI03293_RS08450	COG0747	negative chemotaxis
CFVI03293_RS08455	COG0601	transmembrane transport
CFVI03293_RS08460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CFVI03293_RS08475	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CFVI03293_RS08495	COG0754	glutathionylspermidine amidase activity
CFVI03293_RS08500	COG0163	prenyltransferase activity
CFVI03293_RS08505	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CFVI03293_RS08510	COG1666	GTP binding
CFVI03293_RS08515	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CFVI03293_RS08520	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CFVI03293_RS08530	COG0318	PFAM AMP-dependent synthetase and ligase
CFVI03293_RS08535	COG2067	long-chain fatty acid transport protein
CFVI03293_RS08540	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CFVI03293_RS08615	COG0861	Integral membrane protein TerC family
CFVI03293_RS08625	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CFVI03293_RS08625	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CFVI03293_RS08630	COG0606	chelatase, subunit chli
CFVI03293_RS08635	COG0242	peptide deformylase activity
CFVI03293_RS08645	COG0740	serine-type endopeptidase activity
CFVI03293_RS08650	COG0544	peptidyl-prolyl cis-trans isomerase activity
CFVI03293_RS08655	COG0302	gtp cyclohydrolase
CFVI03293_RS08660	COG1157	protein secretion by the type III secretion system
CFVI03293_RS08665	COG1104	cysteine desulfurase activity
CFVI03293_RS08690	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CFVI03293_RS08695	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CFVI03293_RS08750	COG1981	membrane
CFVI03293_RS08760	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CFVI03293_RS08765	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CFVI03293_RS08770	COG0268	Binds directly to 16S ribosomal RNA
CFVI03293_RS08775	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CFVI03293_RS08780	COG2315	Protein conserved in bacteria
CFVI03293_RS08790	COG0708	Exodeoxyribonuclease III
CFVI03293_RS08795	COG2194	sulfuric ester hydrolase activity
CFVI03293_RS08800	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CFVI03293_RS08820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CFVI03293_RS08825	COG1121	(ABC) transporter
CFVI03293_RS08835	COG3443	Belongs to the bacterial solute-binding protein 9 family
CFVI03293_RS08845	COG1858	cytochrome C peroxidase
CFVI03293_RS08850	COG2200	EAL domain
CFVI03293_RS08855	COG0288	reversible hydration of carbon dioxide
CFVI03293_RS08860	COG0668	transmembrane transport
CFVI03293_RS08870	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CFVI03293_RS08875	COG0571	ribonuclease III activity
CFVI03293_RS08890	COG0358	DNA primase activity
CFVI03293_RS08910	COG2056	Na+-H+ antiporter family
CFVI03293_RS08920	COG1696	Membrane protein involved in D-alanine export
CFVI03293_RS08925	COG0129	dihydroxy-acid dehydratase activity
CFVI03293_RS08930	COG0737	Belongs to the 5'-nucleotidase family
CFVI03293_RS08940	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CFVI03293_RS08945	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CFVI03293_RS08950	COG0582	viral genome integration into host DNA
CFVI03293_RS08970	COG0629	single-stranded DNA binding
CFVI03293_RS09020	COG3451	type IV secretory pathway VirB4
CFVI03293_RS09045	COG4962	Type ii secretion system protein e
CFVI03293_RS09080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CFVI03293_RS09120	COG4615	Cyclic peptide transporter
CFVI03293_RS09125	COG0748	coenzyme F420 binding
CFVI03293_RS09140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CFVI03293_RS09145	COG1120	ATPase activity
CFVI03293_RS09150	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CFVI03293_RS09175	COG1749	Flagellar hook protein flgE
CFVI03293_RS09185	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CFVI03293_RS09190	COG0237	dephospho-CoA kinase activity
CFVI03293_RS09195	COG0251	oxidation-reduction process
CFVI03293_RS09200	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CFVI03293_RS09210	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CFVI03293_RS09210	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CFVI03293_RS09220	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CFVI03293_RS09230	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CFVI03293_RS09235	COG0233	cytoplasmic translational termination
CFVI03293_RS09245	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CFVI03293_RS09250	COG0670	Belongs to the BI1 family
CFVI03293_RS09290	COG2249	NAD(P)H dehydrogenase (quinone) activity
CFVI03293_RS09330	COG2259	Doxx family
CFVI03293_RS09335	COG0778	Nitroreductase
CFVI03293_RS09355	COG1187	pseudouridine synthase activity
CFVI03293_RS09360	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CFVI03293_RS09360	COG0517	IMP dehydrogenase activity
CFVI03293_RS09370	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CFVI03293_RS09375	COG2814	Major facilitator Superfamily
CFVI03293_RS09380	COG0107	imidazoleglycerol-phosphate synthase activity
CFVI03293_RS09390	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CFVI03293_RS09400	COG0564	pseudouridine synthase activity
CFVI03293_RS09405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CFVI03293_RS09410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CFVI03293_RS09415	COG0833	amino acid
CFVI03293_RS09420	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CFVI03293_RS09425	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CFVI03293_RS09445	COG0187	DNA topoisomerase II activity
CFVI03293_RS09515	COG1217	gtp-binding protein TYPA
CFVI03293_RS09770	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CFVI03293_RS09790	COG1966	Carbon starvation protein
CFVI03293_RS09995	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CFVI03293_RS10020	COG0187	DNA topoisomerase II activity
CFVI03293_RS10170	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids