locus-tag	class	description
H5A01_RS00010	COG0577	efflux transmembrane transporter activity
H5A01_RS00010	COG1136	(ABC) transporter
H5A01_RS00015	COG1538	Outer membrane efflux protein
H5A01_RS00045	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H5A01_RS00050	COG1388	LysM domain
H5A01_RS00050	COG0791	NLP P60 protein
H5A01_RS00055	COG0084	hydrolase, TatD family'
H5A01_RS00065	COG0497	DNA recombination
H5A01_RS00070	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H5A01_RS00080	COG0563	adenylate kinase activity
H5A01_RS00085	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H5A01_RS00090	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5A01_RS00105	COG0758	DNA mediated transformation
H5A01_RS00120	COG0557	exoribonuclease II activity
H5A01_RS00135	COG0375	protein maturation
H5A01_RS00140	COG0309	Hydrogenase expression formation protein (HypE)
H5A01_RS00145	COG0409	Hydrogenase expression formation protein
H5A01_RS00150	COG0298	carbon dioxide binding
H5A01_RS00160	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H5A01_RS00175	COG0534	Mate efflux family protein
H5A01_RS00190	COG0581	inorganic phosphate transmembrane transporter activity
H5A01_RS00195	COG0573	inorganic phosphate transmembrane transporter activity
H5A01_RS00200	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H5A01_RS00205	COG1528	Iron-storage protein
H5A01_RS00245	COG0586	Pfam SNARE associated Golgi protein
H5A01_RS00250	COG0039	L-malate dehydrogenase activity
H5A01_RS00260	COG3610	response to peptide
H5A01_RS00280	COG2217	Heavy metal translocating P-type atpase
H5A01_RS00295	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H5A01_RS00300	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H5A01_RS00305	COG2217	Heavy metal translocating P-type atpase
H5A01_RS00320	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H5A01_RS00330	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
H5A01_RS00330	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
H5A01_RS00350	COG1216	Glycosyl transferase, family 2
H5A01_RS00355	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
H5A01_RS00355	COG0662	Cupin 2, conserved barrel domain protein
H5A01_RS00360	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
H5A01_RS00385	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H5A01_RS00395	COG0028	Belongs to the TPP enzyme family
H5A01_RS00430	COG1560	Kdo2-lipid A biosynthetic process
H5A01_RS00435	COG0859	PFAM glycosyl transferase family 9
H5A01_RS00445	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H5A01_RS00450	COG1132	(ABC) transporter
H5A01_RS00455	COG0438	transferase activity, transferring glycosyl groups
H5A01_RS00460	COG1215	transferase activity, transferring glycosyl groups
H5A01_RS00465	COG0438	transferase activity, transferring glycosyl groups
H5A01_RS00470	COG1287	oligosaccharyl transferase activity
H5A01_RS00475	COG0438	transferase activity, transferring glycosyl groups
H5A01_RS00480	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H5A01_RS00485	COG0110	maltose O-acetyltransferase activity
H5A01_RS00490	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H5A01_RS00495	COG1086	Polysaccharide biosynthesis protein
H5A01_RS00505	COG0745	RESPONSE REGULATOR receiver
H5A01_RS00515	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H5A01_RS00525	COG1183	phosphatidylcholine synthase activity
H5A01_RS00530	COG2833	Protein of unknown function (DUF455)
H5A01_RS00535	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H5A01_RS00540	COG2095	MarC family integral membrane protein
H5A01_RS00550	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H5A01_RS00555	COG0542	response to heat
H5A01_RS00560	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H5A01_RS00570	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H5A01_RS00590	COG0210	DNA helicase
H5A01_RS00610	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H5A01_RS00615	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H5A01_RS00620	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H5A01_RS00625	COG1862	Preprotein translocase
H5A01_RS00630	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H5A01_RS00635	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H5A01_RS00655	COG0285	dihydrofolate synthase activity
H5A01_RS00660	COG0739	heme binding
H5A01_RS00690	COG2124	cytochrome p450
H5A01_RS00700	COG0736	holo-[acyl-carrier-protein] synthase activity
H5A01_RS00705	COG1580	Controls the rotational direction of flagella during chemotaxis
H5A01_RS00730	COG0126	phosphoglycerate kinase activity
H5A01_RS00740	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H5A01_RS00745	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H5A01_RS00750	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H5A01_RS00755	COG1918	ferrous iron import across plasma membrane
H5A01_RS00795	COG0251	oxidation-reduction process
H5A01_RS00800	COG2964	Protein conserved in bacteria
H5A01_RS00810	COG0753	catalase activity
H5A01_RS00840	COG3276	selenocysteine insertion sequence binding
H5A01_RS00855	COG2814	Major facilitator Superfamily
H5A01_RS00860	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H5A01_RS00875	COG2853	Lipoprotein
H5A01_RS00885	COG2252	PERMEase
H5A01_RS00890	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H5A01_RS00900	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H5A01_RS00905	COG0114	fumarate hydratase activity
H5A01_RS00910	COG0628	permease
H5A01_RS00935	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H5A01_RS00940	COG3005	denitrification pathway
H5A01_RS00945	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H5A01_RS00960	COG4607	ABC-type enterochelin transport system periplasmic component
H5A01_RS00965	COG4604	ABC transporter, ATP-binding protein
H5A01_RS00970	COG4605	iron ion homeostasis
H5A01_RS00975	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5A01_RS00980	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
H5A01_RS00990	COG1293	RNA-binding protein homologous to eukaryotic snRNP
H5A01_RS01000	COG0575	Belongs to the CDS family
H5A01_RS01015	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H5A01_RS01020	COG2165	general secretion pathway protein
H5A01_RS01040	COG0826	peptidase U32
H5A01_RS01045	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H5A01_RS01055	COG0752	glycyl-tRNA synthetase alpha subunit
H5A01_RS01060	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H5A01_RS01070	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H5A01_RS01070	COG1519	Transferase
H5A01_RS01075	COG0564	pseudouridine synthase activity
H5A01_RS01080	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H5A01_RS01085	COG0228	four-way junction DNA binding
H5A01_RS01090	COG1837	Belongs to the UPF0109 family
H5A01_RS01115	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H5A01_RS01120	COG1393	Belongs to the ArsC family
H5A01_RS01130	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H5A01_RS01140	COG0418	dihydroorotase activity
H5A01_RS01150	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H5A01_RS01155	COG2194	sulfuric ester hydrolase activity
H5A01_RS01160	COG0708	Exodeoxyribonuclease III
H5A01_RS01170	COG2921	Belongs to the UPF0250 family
H5A01_RS01185	COG0477	Major facilitator Superfamily
H5A01_RS01210	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H5A01_RS01215	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H5A01_RS01240	COG0668	transmembrane transport
H5A01_RS01245	COG0288	reversible hydration of carbon dioxide
H5A01_RS01250	COG0670	Belongs to the BI1 family
H5A01_RS01255	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H5A01_RS01275	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5A01_RS01290	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H5A01_RS01295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H5A01_RS01345	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H5A01_RS01350	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
H5A01_RS01355	COG1968	undecaprenyl-diphosphatase activity
H5A01_RS01360	COG1297	OPT oligopeptide transporter protein
H5A01_RS01365	COG2851	Citrate transporter
H5A01_RS01375	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H5A01_RS01375	COG0512	Glutamine amidotransferase of anthranilate synthase
H5A01_RS01380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H5A01_RS01385	COG0582	viral genome integration into host DNA
H5A01_RS01395	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H5A01_RS01430	COG2404	hydrolase activity, acting on ester bonds
H5A01_RS01435	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H5A01_RS01440	COG1959	2 iron, 2 sulfur cluster binding
H5A01_RS01445	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H5A01_RS01450	COG1674	ftsk spoiiie
H5A01_RS01450	COG1196	nuclear chromosome segregation
H5A01_RS01505	COG0598	Magnesium transport protein CorA
H5A01_RS01510	COG0521	Mo-molybdopterin cofactor biosynthetic process
H5A01_RS01520	COG0501	Belongs to the peptidase M48B family
H5A01_RS01525	COG2890	protein-(glutamine-N5) methyltransferase activity
H5A01_RS01540	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H5A01_RS01545	COG0587	DNA-directed DNA polymerase activity
H5A01_RS01560	COG1074	ATP-dependent DNA helicase activity
H5A01_RS01565	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H5A01_RS01570	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H5A01_RS01580	COG0546	phosphoglycolate phosphatase activity
H5A01_RS01610	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H5A01_RS01615	COG1459	type II secretion system
H5A01_RS01620	COG0730	response to heat
H5A01_RS01645	COG3951	Flagellar rod assembly protein muramidase FlgJ
H5A01_RS01670	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H5A01_RS01690	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H5A01_RS01740	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H5A01_RS01740	COG0517	IMP dehydrogenase activity
H5A01_RS01745	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
H5A01_RS01770	COG0688	phosphatidylethanolamine metabolic process
H5A01_RS01775	COG1408	metallophosphoesterase
H5A01_RS01780	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5A01_RS01805	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H5A01_RS01820	COG0492	ferredoxin-NADP+ reductase activity
H5A01_RS01825	COG3118	belongs to the thioredoxin family
H5A01_RS01830	COG0792	nuclease activity
H5A01_RS01835	COG0460	homoserine dehydrogenase
H5A01_RS01840	COG0436	Aminotransferase
H5A01_RS01855	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H5A01_RS01860	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H5A01_RS01865	COG0254	rRNA binding
H5A01_RS01870	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H5A01_RS01920	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H5A01_RS01935	COG2992	FlgJ-related protein
H5A01_RS01945	COG0783	Belongs to the Dps family
H5A01_RS01965	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H5A01_RS01970	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H5A01_RS01980	COG0839	Belongs to the complex I subunit 6 family
H5A01_RS01985	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H5A01_RS01990	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H5A01_RS02015	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H5A01_RS02025	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H5A01_RS02040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H5A01_RS02045	COG0601	transmembrane transport
H5A01_RS02055	COG0243	molybdopterin cofactor binding
H5A01_RS02060	COG0437	4 iron, 4 sulfur cluster binding
H5A01_RS02100	COG4615	Cyclic peptide transporter
H5A01_RS02120	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H5A01_RS02125	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H5A01_RS02135	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H5A01_RS02140	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H5A01_RS02145	COG0202	RNA polymerase activity
H5A01_RS02150	COG0203	ribosomal protein L17
H5A01_RS02165	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H5A01_RS02165	COG0131	Imidazoleglycerol-phosphate dehydratase
H5A01_RS02175	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H5A01_RS02190	COG0140	phosphoribosyl-ATP diphosphatase activity
H5A01_RS02190	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H5A01_RS02195	COG2171	N-acyltransferase activity
H5A01_RS02200	COG0489	protein tyrosine kinase activity
H5A01_RS02215	COG2046	Belongs to the sulfate adenylyltransferase family
H5A01_RS02230	COG0039	L-malate dehydrogenase activity
H5A01_RS02240	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H5A01_RS02250	COG0674	pyruvate-flavodoxin oxidoreductase activity
H5A01_RS02250	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H5A01_RS02255	COG1013	pyruvate-flavodoxin oxidoreductase activity
H5A01_RS02275	COG0142	geranyltranstransferase activity
H5A01_RS02280	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H5A01_RS02285	COG0442	prolyl-tRNA aminoacylation
H5A01_RS02295	COG0181	hydroxymethylbilane synthase activity
H5A01_RS02300	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H5A01_RS02310	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H5A01_RS02330	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H5A01_RS02360	COG1289	transmembrane transporter activity
H5A01_RS02365	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H5A01_RS02370	COG0492	ferredoxin-NADP+ reductase activity
H5A01_RS02385	COG0305	Participates in initiation and elongation during chromosome replication
H5A01_RS02415	COG0745	RESPONSE REGULATOR receiver
H5A01_RS02420	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H5A01_RS02435	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H5A01_RS02435	COG1776	CheC inhibitor of MCP methylation
H5A01_RS02450	COG0133	tryptophan synthase activity
H5A01_RS02460	COG0512	Glutamine amidotransferase of anthranilate synthase
H5A01_RS02460	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H5A01_RS02475	COG0730	response to heat
H5A01_RS02480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H5A01_RS02485	COG1238	metal cluster binding
H5A01_RS02495	COG0477	Major facilitator Superfamily
H5A01_RS02505	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H5A01_RS02510	COG1360	Flagellar Motor Protein
H5A01_RS02515	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H5A01_RS02520	COG0450	alkyl hydroperoxide reductase
H5A01_RS02535	COG0187	DNA topoisomerase II activity
H5A01_RS02540	COG0592	DNA-directed DNA polymerase activity
H5A01_RS02550	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H5A01_RS02555	COG1749	Flagellar hook protein flgE
H5A01_RS02565	COG2391	methyltransferase activity
H5A01_RS02570	COG0425	Belongs to the sulfur carrier protein TusA family
H5A01_RS02575	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H5A01_RS02585	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H5A01_RS02600	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
H5A01_RS02605	COG0473	3-isopropylmalate dehydrogenase activity
H5A01_RS02610	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H5A01_RS02650	COG0820	rRNA (adenine-C2-)-methyltransferase activity
H5A01_RS02665	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H5A01_RS02670	COG1187	pseudouridine synthase activity
H5A01_RS02680	COG0051	transcription antitermination factor activity, RNA binding
H5A01_RS02685	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H5A01_RS02705	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H5A01_RS02715	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H5A01_RS02720	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H5A01_RS02725	COG0255	Belongs to the universal ribosomal protein uL29 family
H5A01_RS02730	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H5A01_RS02735	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H5A01_RS02740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H5A01_RS02745	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H5A01_RS02750	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H5A01_RS02755	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H5A01_RS02760	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H5A01_RS02765	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H5A01_RS02770	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H5A01_RS02775	COG0200	Binds to the 23S rRNA
H5A01_RS02780	COG0201	protein transport
H5A01_RS02790	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H5A01_RS02805	COG0372	Belongs to the citrate synthase family
H5A01_RS02810	COG1218	3'(2'),5'-bisphosphate nucleotidase
H5A01_RS02820	COG0812	UDP-N-acetylmuramate dehydrogenase activity
H5A01_RS02825	COG1987	bacterial-type flagellum assembly
H5A01_RS02830	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
H5A01_RS02835	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H5A01_RS02840	COG0148	phosphopyruvate hydratase activity
H5A01_RS02855	COG1793	dna ligase
H5A01_RS02905	COG1136	(ABC) transporter
H5A01_RS02930	COG0672	)-iron permease
H5A01_RS02945	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5A01_RS02950	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H5A01_RS02955	COG0791	NLP P60 protein
H5A01_RS02960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H5A01_RS02965	COG0024	Methionine aminopeptidase
H5A01_RS02975	COG3218	ABC-type transport auxiliary lipoprotein component
H5A01_RS02975	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H5A01_RS02985	COG1127	ABC transporter
H5A01_RS02990	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H5A01_RS02995	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H5A01_RS03010	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H5A01_RS03015	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H5A01_RS03040	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H5A01_RS03055	COG1160	GTP binding
H5A01_RS03090	COG0579	oxidoreductase
H5A01_RS03095	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H5A01_RS03110	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H5A01_RS03115	COG1049	propionate catabolic process, 2-methylcitrate cycle
H5A01_RS03125	COG4221	oxidoreductase activity
H5A01_RS03130	COG1757	Na H antiporter
H5A01_RS03135	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H5A01_RS03150	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H5A01_RS03155	COG0101	tRNA pseudouridine synthase activity
H5A01_RS03190	COG1338	Plays a role in the flagellum-specific transport system
H5A01_RS03220	COG1295	ribonuclease BN
H5A01_RS03225	COG0277	FAD linked oxidase domain protein
H5A01_RS03235	COG0739	heme binding
H5A01_RS03245	COG1496	oxidoreductase activity
H5A01_RS03260	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H5A01_RS03270	COG0642	Histidine kinase
H5A01_RS03275	COG0745	RESPONSE REGULATOR receiver
H5A01_RS03295	COG0642	Histidine kinase
H5A01_RS03300	COG0745	RESPONSE REGULATOR receiver
H5A01_RS03305	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H5A01_RS03310	COG0484	heat shock protein binding
H5A01_RS03315	COG0789	Transcriptional regulator
H5A01_RS03320	COG0475	glutathione-regulated potassium exporter activity
H5A01_RS03320	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H5A01_RS03330	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H5A01_RS03335	COG0751	glycine-tRNA ligase activity
H5A01_RS03340	COG0739	heme binding
H5A01_RS03350	COG0248	Ppx GppA phosphatase
H5A01_RS03360	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H5A01_RS03370	COG2814	Major facilitator Superfamily
H5A01_RS03385	COG0731	radical SAM domain protein
H5A01_RS03405	COG0518	GMP synthase (glutamine-hydrolyzing) activity
H5A01_RS03405	COG0519	Catalyzes the synthesis of GMP from XMP
H5A01_RS03430	COG1185	polyribonucleotide nucleotidyltransferase activity
H5A01_RS03445	COG1473	amidohydrolase
H5A01_RS03465	COG0733	neurotransmitter:sodium symporter activity
H5A01_RS03485	COG0191	fructose-bisphosphate aldolase activity
H5A01_RS03490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5A01_RS03495	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H5A01_RS03505	COG2860	membrane
H5A01_RS03520	COG2890	protein-(glutamine-N5) methyltransferase activity
H5A01_RS03525	COG0196	riboflavin kinase activity
H5A01_RS03540	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H5A01_RS03545	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H5A01_RS03560	COG0527	aspartate kinase activity
H5A01_RS03565	COG0494	nUDIX hydrolase
H5A01_RS03570	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H5A01_RS03580	COG0805	protein transport
H5A01_RS03585	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H5A01_RS03595	COG0440	acetolactate synthase activity
H5A01_RS03600	COG0028	Belongs to the TPP enzyme family
H5A01_RS03605	COG1610	YqeY-like protein
H5A01_RS03610	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5A01_RS03610	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5A01_RS03640	COG0835	chemotaxis
H5A01_RS03645	COG2198	Histidine kinase
H5A01_RS03645	COG0643	Histidine kinase
H5A01_RS03645	COG0784	Response regulator, receiver
H5A01_RS03650	COG0835	chemotaxis
H5A01_RS03650	COG0784	Response regulator, receiver
H5A01_RS03725	COG4106	trans-aconitate 2-methyltransferase activity
H5A01_RS03730	COG2830	Protein of unknown function (DUF452)
H5A01_RS03740	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H5A01_RS03745	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H5A01_RS03750	COG2076	Multidrug Resistance protein
H5A01_RS03765	COG0193	aminoacyl-tRNA hydrolase activity
H5A01_RS03775	COG0019	diaminopimelate decarboxylase activity
H5A01_RS03790	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H5A01_RS03800	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H5A01_RS03810	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H5A01_RS03825	COG0247	lactate metabolic process
H5A01_RS03825	COG2181	nitrate reductase activity
H5A01_RS03840	COG2807	transmembrane transport
H5A01_RS03845	COG1473	amidohydrolase
H5A01_RS03850	COG3022	response to hydroperoxide
H5A01_RS03870	COG0328	RNA-DNA hybrid ribonuclease activity
H5A01_RS03875	COG0571	ribonuclease III activity
H5A01_RS03880	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H5A01_RS03905	COG0848	biopolymer transport protein
H5A01_RS03910	COG0811	peptide transport
H5A01_RS03925	COG0814	amino acid
H5A01_RS03930	COG1760	l-serine dehydratase
H5A01_RS03940	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5A01_RS03940	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H5A01_RS03970	COG1194	a g-specific adenine glycosylase
H5A01_RS03975	COG0477	Major facilitator Superfamily
H5A01_RS03980	COG0166	Belongs to the GPI family
H5A01_RS03990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H5A01_RS03995	COG3839	Belongs to the ABC transporter superfamily
H5A01_RS04000	COG4662	Binding-protein-dependent transport system inner membrane component
H5A01_RS04005	COG2998	abc-type tungstate transport system, permease component
H5A01_RS04010	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H5A01_RS04015	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H5A01_RS04020	COG1984	allophanate hydrolase subunit 2
H5A01_RS04030	COG2249	NAD(P)H dehydrogenase (quinone) activity
H5A01_RS04040	COG1064	alcohol dehydrogenase
H5A01_RS04110	COG0798	PFAM Bile acid sodium symporter
H5A01_RS04130	COG0582	viral genome integration into host DNA
H5A01_RS04185	COG1333	cytochrome c biogenesis protein
H5A01_RS04185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H5A01_RS04235	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H5A01_RS04240	COG2204	response regulator
H5A01_RS04255	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H5A01_RS04270	COG0481	GTPase activity
H5A01_RS04295	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H5A01_RS04305	COG0439	Biotin carboxylase
H5A01_RS04310	COG0772	Belongs to the SEDS family
H5A01_RS04315	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H5A01_RS04355	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H5A01_RS04360	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H5A01_RS04375	COG0250	Participates in transcription elongation, termination and antitermination
H5A01_RS04380	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H5A01_RS04385	COG0081	regulation of translation
H5A01_RS04390	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H5A01_RS04395	COG0222	ribosome binding
H5A01_RS04405	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
H5A01_RS04410	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H5A01_RS04415	COG0049	tRNA binding
H5A01_RS04435	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
H5A01_RS04460	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H5A01_RS04475	COG1815	bacterial-type flagellum-dependent cell motility
H5A01_RS04480	COG1558	bacterial-type flagellum-dependent cell motility
H5A01_RS04485	COG1677	Flagellar hook-basal body complex protein FliE
H5A01_RS04505	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H5A01_RS04520	COG0204	Acyl-transferase
H5A01_RS04530	COG0047	phosphoribosylformylglycinamidine synthase activity
H5A01_RS04535	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H5A01_RS04540	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H5A01_RS04545	COG0793	Belongs to the peptidase S41A family
H5A01_RS04550	COG1937	Protein conserved in bacteria
H5A01_RS04555	COG0542	response to heat
H5A01_RS04565	COG0424	maF-like protein
H5A01_RS04580	COG0673	inositol 2-dehydrogenase activity
H5A01_RS04590	COG0004	ammonium transporteR
H5A01_RS04600	COG1419	protein localization to endoplasmic reticulum
H5A01_RS04605	COG0455	bacterial-type flagellum organization
H5A01_RS04615	COG1191	sigma factor activity
H5A01_RS04620	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H5A01_RS04625	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H5A01_RS04625	COG1776	CheC inhibitor of MCP methylation
H5A01_RS04640	COG0154	amidase activity
H5A01_RS04645	COG0516	GMP reductase activity
H5A01_RS04645	COG0517	IMP dehydrogenase activity
H5A01_RS04675	COG1193	negative regulation of DNA recombination
H5A01_RS04705	COG2022	thiamine diphosphate biosynthetic process
H5A01_RS04710	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H5A01_RS04715	COG0352	thiamine-phosphate diphosphorylase activity
H5A01_RS04735	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H5A01_RS04745	COG1077	Cell shape determining protein MreB Mrl
H5A01_RS04750	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H5A01_RS04755	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H5A01_RS04765	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H5A01_RS04770	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H5A01_RS04775	COG1942	4-Oxalocrotonate Tautomerase
H5A01_RS04785	COG0330	HflC and HflK could
H5A01_RS04805	COG2089	acid synthase
H5A01_RS04820	COG0107	imidazoleglycerol-phosphate synthase activity
H5A01_RS04825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H5A01_RS04830	COG3980	spore coat polysaccharide biosynthesis protein
H5A01_RS04835	COG1083	cytidylyl-transferase
H5A01_RS04880	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H5A01_RS04885	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H5A01_RS04915	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H5A01_RS04920	COG1027	Aspartate ammonia-lyase
H5A01_RS04930	COG1794	racemase activity, acting on amino acids and derivatives
H5A01_RS04935	COG1294	oxidase, subunit
H5A01_RS04940	COG1271	oxidase subunit
H5A01_RS04970	COG0247	lactate metabolic process
H5A01_RS04975	COG1139	Iron-sulfur cluster binding protein
H5A01_RS05000	COG0616	signal peptide processing
H5A01_RS05005	COG0402	S-adenosylhomocysteine deaminase activity
H5A01_RS05010	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H5A01_RS05020	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H5A01_RS05035	COG0564	pseudouridine synthase activity
H5A01_RS05040	COG0772	Belongs to the SEDS family
H5A01_RS05055	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H5A01_RS05060	COG0569	domain protein
H5A01_RS05065	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
H5A01_RS05070	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H5A01_RS05075	COG0281	malic enzyme
H5A01_RS05075	COG0280	phosphate acetyltransferase
H5A01_RS05080	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H5A01_RS05090	COG0439	Biotin carboxylase
H5A01_RS05095	COG0511	ligase activity, forming carbon-carbon bonds
H5A01_RS05105	COG1086	Polysaccharide biosynthesis protein
H5A01_RS05110	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H5A01_RS05130	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H5A01_RS05145	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H5A01_RS05150	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H5A01_RS05155	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H5A01_RS05175	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H5A01_RS05180	COG0754	glutathionylspermidine amidase activity
H5A01_RS05190	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H5A01_RS05205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H5A01_RS05215	COG1538	Outer membrane efflux protein
H5A01_RS05225	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H5A01_RS05230	COG1981	membrane
H5A01_RS05235	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H5A01_RS05240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
H5A01_RS05270	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H5A01_RS05275	COG2011	ABC-type metal ion transport system permease component
H5A01_RS05280	COG1464	Belongs to the NlpA lipoprotein family
H5A01_RS05285	COG1464	Belongs to the NlpA lipoprotein family
H5A01_RS05290	COG1464	Belongs to the NlpA lipoprotein family
H5A01_RS05300	COG0163	prenyltransferase activity
H5A01_RS05305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H5A01_RS05320	COG1166	arginine decarboxylase activity
H5A01_RS05325	COG1045	serine acetyltransferase
H5A01_RS05330	COG0436	Aminotransferase
H5A01_RS05345	COG0443	Heat shock 70 kDa protein
H5A01_RS05355	COG1420	regulation of RNA biosynthetic process
H5A01_RS05405	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H5A01_RS05405	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H5A01_RS05410	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H5A01_RS05415	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H5A01_RS05420	COG1157	protein secretion by the type III secretion system
H5A01_RS05430	COG0544	peptidyl-prolyl cis-trans isomerase activity
H5A01_RS05440	COG0242	peptide deformylase activity
H5A01_RS05445	COG0606	chelatase, subunit chli
H5A01_RS05455	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H5A01_RS05455	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H5A01_RS05460	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H5A01_RS05465	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H5A01_RS05470	COG1126	abc transporter atp-binding protein
H5A01_RS05475	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5A01_RS05480	COG0765	amino acid transport
H5A01_RS05485	COG0765	amino acid transport
H5A01_RS05490	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H5A01_RS05495	COG1966	Carbon starvation protein
H5A01_RS05515	COG0776	regulation of translation
H5A01_RS05520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H5A01_RS05525	COG1999	signal sequence binding
H5A01_RS05550	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H5A01_RS05555	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H5A01_RS05560	COG1115	amino acid carrier protein
H5A01_RS05570	COG0765	amino acid transport
H5A01_RS05585	COG0537	adenosine 5'-monophosphoramidase activity
H5A01_RS05590	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H5A01_RS05595	COG0072	phenylalanine-tRNA ligase activity
H5A01_RS05595	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5A01_RS05600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H5A01_RS05610	COG1185	polyribonucleotide nucleotidyltransferase activity
H5A01_RS05610	COG0539	negative regulation of cytoplasmic translation
H5A01_RS05620	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H5A01_RS05625	COG0745	RESPONSE REGULATOR receiver
H5A01_RS05635	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H5A01_RS05640	COG0217	transcriptional regulatory protein
H5A01_RS05655	COG0018	arginyl-trna synthetase
H5A01_RS05660	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H5A01_RS05665	COG0194	GDP metabolic process
H5A01_RS05685	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5A01_RS05770	COG1121	(ABC) transporter
H5A01_RS05775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H5A01_RS05785	COG1401	restriction endodeoxyribonuclease activity
H5A01_RS05810	COG0083	homoserine kinase activity
H5A01_RS05835	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H5A01_RS05845	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H5A01_RS05855	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H5A01_RS05865	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H5A01_RS05890	COG0037	tRNA processing
H5A01_RS05895	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H5A01_RS05900	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H5A01_RS05905	COG1047	Peptidyl-prolyl cis-trans
H5A01_RS05915	COG2885	chlorophyll binding
H5A01_RS05930	COG0848	biopolymer transport protein
H5A01_RS05935	COG0811	peptide transport
H5A01_RS05940	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H5A01_RS05945	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H5A01_RS05960	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H5A01_RS05975	COG1475	DNA binding
H5A01_RS05980	COG1192	Involved in chromosome partitioning
H5A01_RS06000	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H5A01_RS06005	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H5A01_RS06025	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H5A01_RS06030	COG0583	DNA-binding transcription factor activity
H5A01_RS06035	COG2855	membrane
H5A01_RS06045	COG0357	Ribosomal RNA small subunit methyltransferase G
H5A01_RS06050	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H5A01_RS06055	COG0113	porphobilinogen synthase activity
H5A01_RS06060	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H5A01_RS06070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H5A01_RS06095	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H5A01_RS06100	COG0681	Belongs to the peptidase S26 family
H5A01_RS06105	COG0303	'Molybdopterin
H5A01_RS06135	COG1217	gtp-binding protein TYPA
H5A01_RS06150	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H5A01_RS06170	COG1684	flagellar biosynthetic protein fliR
H5A01_RS06180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H5A01_RS06185	COG0052	Belongs to the universal ribosomal protein uS2 family
H5A01_RS06190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H5A01_RS06200	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H5A01_RS06205	COG0723	plastoquinol--plastocyanin reductase activity
H5A01_RS06210	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H5A01_RS06215	COG0445	tRNA wobble uridine modification
H5A01_RS06235	COG1301	dicarboxylic acid transport
H5A01_RS06250	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H5A01_RS06260	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H5A01_RS06265	COG0356	it plays a direct role in the translocation of protons across the membrane
H5A01_RS06270	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H5A01_RS06275	COG0552	protein localization to endoplasmic reticulum
H5A01_RS06335	COG2195	Cleaves the N-terminal amino acid of tripeptides
H5A01_RS06340	COG0477	Major facilitator Superfamily
H5A01_RS06345	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H5A01_RS06400	COG1091	dTDP-4-dehydrorhamnose reductase activity
H5A01_RS06430	COG1181	Belongs to the D-alanine--D-alanine ligase family
H5A01_RS06435	COG0632	four-way junction helicase activity
H5A01_RS06445	COG0728	peptidoglycan biosynthetic process
H5A01_RS06450	COG0215	cysteine-tRNA ligase activity
H5A01_RS06455	COG1132	(ABC) transporter
H5A01_RS06460	COG0167	dihydroorotate dehydrogenase activity
H5A01_RS06465	COG0612	Peptidase, M16
H5A01_RS06475	COG1028	Short-chain dehydrogenase reductase Sdr
H5A01_RS06490	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H5A01_RS06500	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H5A01_RS06505	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H5A01_RS06525	COG1971	Probably functions as a manganese efflux pump
H5A01_RS06550	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H5A01_RS06555	COG0602	queuosine metabolic process
H5A01_RS06580	COG1028	Short-chain dehydrogenase reductase Sdr
H5A01_RS06595	COG1739	Uncharacterized protein family UPF0029
H5A01_RS06610	COG0488	(ABC) transporter
H5A01_RS06620	COG2353	YceI-like domain
H5A01_RS06665	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H5A01_RS06670	COG1053	succinate dehydrogenase
H5A01_RS06690	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H5A01_RS06705	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H5A01_RS06710	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H5A01_RS06750	COG0765	amino acid transport
H5A01_RS06765	COG2346	COG2346, Truncated hemoglobins
H5A01_RS06770	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H5A01_RS06775	COG0612	Peptidase, M16
H5A01_RS06780	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H5A01_RS06790	COG0195	Participates in both transcription termination and antitermination
H5A01_RS06805	COG2121	Domain of unknown function (DUF374)
H5A01_RS06835	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H5A01_RS06840	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H5A01_RS06850	COG0840	transmembrane signaling receptor activity
H5A01_RS06855	COG0494	nUDIX hydrolase
H5A01_RS06860	COG4771	TonB-dependent receptor
H5A01_RS06870	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H5A01_RS06875	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H5A01_RS06880	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H5A01_RS06890	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H5A01_RS06905	COG1028	Short-chain dehydrogenase reductase Sdr
H5A01_RS06920	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H5A01_RS06940	COG2226	methyltransferase
H5A01_RS06945	COG1570	exodeoxyribonuclease VII activity
H5A01_RS06950	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H5A01_RS06955	COG0251	oxidation-reduction process
H5A01_RS06960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H5A01_RS06965	COG0416	fatty acid biosynthetic process
H5A01_RS06970	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H5A01_RS06980	COG0105	UTP biosynthetic process
H5A01_RS07015	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H5A01_RS07020	COG0012	GTP binding
H5A01_RS07030	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H5A01_RS07035	COG5016	pyruvate
H5A01_RS07035	COG0511	ligase activity, forming carbon-carbon bonds
H5A01_RS07040	COG0733	neurotransmitter:sodium symporter activity
H5A01_RS07045	COG0733	neurotransmitter:sodium symporter activity
H5A01_RS07110	COG0765	amino acid transport
H5A01_RS07120	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H5A01_RS07125	COG0706	membrane insertase activity
H5A01_RS07145	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H5A01_RS07150	COG0138	bifunctional purine biosynthesis protein purh
H5A01_RS07160	COG0840	transmembrane signaling receptor activity
H5A01_RS07180	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H5A01_RS07195	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H5A01_RS07205	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H5A01_RS07210	COG0653	protein targeting
H5A01_RS07235	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H5A01_RS07240	COG1137	ATPase activity
H5A01_RS07245	COG0802	atpase or kinase
H5A01_RS07250	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H5A01_RS07255	COG0137	argininosuccinate synthase activity
H5A01_RS07275	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H5A01_RS07360	COG0471	metal ion transport
H5A01_RS07390	COG0528	UMP kinase activity
H5A01_RS07395	COG1758	RNA polymerase activity
H5A01_RS07400	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H5A01_RS07420	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H5A01_RS07420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H5A01_RS07425	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H5A01_RS07430	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
H5A01_RS07435	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
H5A01_RS07440	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H5A01_RS07445	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H5A01_RS07450	COG0642	Histidine kinase
H5A01_RS07455	COG0745	RESPONSE REGULATOR receiver
H5A01_RS07460	COG0484	heat shock protein binding
H5A01_RS07465	COG4773	Receptor
H5A01_RS07470	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H5A01_RS07495	COG2814	Major facilitator Superfamily
H5A01_RS07555	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H5A01_RS07560	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
H5A01_RS07570	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H5A01_RS07575	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H5A01_RS07580	COG0629	single-stranded DNA binding
H5A01_RS07590	COG2990	Protein conserved in bacteria
H5A01_RS07595	COG0750	zinc metalloprotease
H5A01_RS07605	COG0778	Nitroreductase
H5A01_RS07620	COG1058	Belongs to the CinA family
H5A01_RS07620	COG1546	Belongs to the CinA family
H5A01_RS07665	COG0303	'Molybdopterin
H5A01_RS07675	COG0314	molybdopterin synthase activity
H5A01_RS07705	COG3383	formate dehydrogenase (NAD+) activity
H5A01_RS07715	COG0437	4 iron, 4 sulfur cluster binding
H5A01_RS07725	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H5A01_RS07755	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H5A01_RS07760	COG0425	Belongs to the sulfur carrier protein TusA family
H5A01_RS07795	COG0505	Belongs to the CarA family
H5A01_RS07810	COG0745	RESPONSE REGULATOR receiver
H5A01_RS07865	COG0488	(ABC) transporter
H5A01_RS07880	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H5A01_RS07905	COG0280	phosphate acetyltransferase
H5A01_RS07915	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H5A01_RS07955	COG0617	tRNA 3'-terminal CCA addition
H5A01_RS07985	COG3043	anaerobic respiration
H5A01_RS07990	COG0348	domain, Protein
H5A01_RS07995	COG0437	4 iron, 4 sulfur cluster binding
H5A01_RS08005	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H5A01_RS08015	COG0210	DNA helicase
H5A01_RS08045	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H5A01_RS08050	COG0849	cell division
H5A01_RS08055	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H5A01_RS08060	COG4786	Flagellar basal body rod
H5A01_RS08065	COG4786	Flagellar basal body rod
H5A01_RS08070	COG0174	glutamine synthetase
H5A01_RS08080	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H5A01_RS08085	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H5A01_RS08115	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H5A01_RS08135	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H5A01_RS08155	COG0824	Thioesterase
H5A01_RS08165	COG1028	Short-chain dehydrogenase reductase Sdr
H5A01_RS08170	COG1083	cytidylyl-transferase
H5A01_RS08180	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H5A01_RS08185	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H5A01_RS08190	COG2089	acid synthase
H5A01_RS08195	COG0861	Integral membrane protein TerC family
H5A01_RS08200	COG2824	Alkylphosphonate utilization operon protein PhnA
H5A01_RS08210	COG1253	flavin adenine dinucleotide binding
H5A01_RS08220	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H5A01_RS08230	COG1840	ABC-type Fe3 transport system, periplasmic component
H5A01_RS08250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H5A01_RS08265	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H5A01_RS08270	COG1120	ATPase activity
H5A01_RS08275	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H5A01_RS08285	COG0748	coenzyme F420 binding
H5A01_RS08290	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H5A01_RS08295	COG0268	Binds directly to 16S ribosomal RNA
H5A01_RS08310	COG0642	Histidine kinase
H5A01_RS08320	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H5A01_RS08355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5A01_RS08355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H5A01_RS08400	COG1733	regulation of RNA biosynthetic process
H5A01_RS08405	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H5A01_RS08410	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H5A01_RS08415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H5A01_RS08590	COG2056	Na+-H+ antiporter family
H5A01_RS08595	COG0070	glutamate synthase
H5A01_RS08595	COG0069	glutamate synthase activity
H5A01_RS08595	COG0067	glutamate synthase
H5A01_RS08600	COG0493	'glutamate synthase
H5A01_RS08605	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H5A01_RS08615	COG1592	Rubrerythrin
H5A01_RS08625	COG3477	response to acidic pH
H5A01_RS08635	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H5A01_RS08650	COG0840	transmembrane signaling receptor activity
H5A01_RS08655	COG1858	cytochrome C peroxidase
H5A01_RS08660	COG0179	Fumarylacetoacetate (FAA) hydrolase
H5A01_RS08665	COG0564	pseudouridine synthase activity
H5A01_RS08670	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H5A01_RS08675	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H5A01_RS08690	COG0504	CTP synthase activity
H5A01_RS08700	COG0252	asparaginase activity