locus-tag	class	description
H4995_RS00005	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H4995_RS00025	COG1218	3'(2'),5'-bisphosphate nucleotidase
H4995_RS00030	COG0372	Belongs to the citrate synthase family
H4995_RS00040	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H4995_RS00045	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H4995_RS00055	COG0201	protein transport
H4995_RS00060	COG0200	Binds to the 23S rRNA
H4995_RS00065	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H4995_RS00070	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H4995_RS00075	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H4995_RS00080	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H4995_RS00085	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H4995_RS00090	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H4995_RS00095	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H4995_RS00100	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H4995_RS00105	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H4995_RS00110	COG0255	Belongs to the universal ribosomal protein uL29 family
H4995_RS00115	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H4995_RS00120	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H4995_RS00125	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H4995_RS00130	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H4995_RS00135	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
H4995_RS00140	COG0089	rRNA binding
H4995_RS00145	COG0088	Forms part of the polypeptide exit tunnel
H4995_RS00150	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H4995_RS00155	COG0051	transcription antitermination factor activity, RNA binding
H4995_RS00160	COG1187	pseudouridine synthase activity
H4995_RS00165	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H4995_RS00245	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
H4995_RS00255	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H4995_RS00260	COG0425	Belongs to the sulfur carrier protein TusA family
H4995_RS00265	COG2391	methyltransferase activity
H4995_RS00275	COG1749	Flagellar hook protein flgE
H4995_RS00280	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
H4995_RS00290	COG0592	DNA-directed DNA polymerase activity
H4995_RS00295	COG0187	DNA topoisomerase II activity
H4995_RS00310	COG2056	Na+-H+ antiporter family
H4995_RS00315	COG0069	glutamate synthase activity
H4995_RS00315	COG0070	glutamate synthase
H4995_RS00315	COG0067	glutamate synthase
H4995_RS00320	COG0493	'glutamate synthase
H4995_RS00325	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H4995_RS00335	COG1592	Rubrerythrin
H4995_RS00355	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H4995_RS00370	COG0840	transmembrane signaling receptor activity
H4995_RS00375	COG1858	cytochrome C peroxidase
H4995_RS00380	COG0179	Fumarylacetoacetate (FAA) hydrolase
H4995_RS00385	COG0564	pseudouridine synthase activity
H4995_RS00390	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H4995_RS00395	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4995_RS00410	COG0504	CTP synthase activity
H4995_RS00420	COG0252	asparaginase activity
H4995_RS00430	COG1058	Belongs to the CinA family
H4995_RS00430	COG1546	Belongs to the CinA family
H4995_RS00435	COG0456	acetyltransferase
H4995_RS00440	COG0778	Nitroreductase
H4995_RS00445	COG0778	Nitroreductase
H4995_RS00455	COG0750	zinc metalloprotease
H4995_RS00460	COG2990	Protein conserved in bacteria
H4995_RS00470	COG0629	single-stranded DNA binding
H4995_RS00475	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H4995_RS00480	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H4995_RS00490	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
H4995_RS00495	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H4995_RS00580	COG3043	anaerobic respiration
H4995_RS00585	COG0348	domain, Protein
H4995_RS00590	COG0437	4 iron, 4 sulfur cluster binding
H4995_RS00600	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H4995_RS00610	COG0210	DNA helicase
H4995_RS00630	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4995_RS00635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H4995_RS00645	COG0839	Belongs to the complex I subunit 6 family
H4995_RS00655	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
H4995_RS00680	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4995_RS00690	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H4995_RS00705	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H4995_RS00710	COG0601	transmembrane transport
H4995_RS00720	COG0277	FAD linked oxidase domain protein
H4995_RS00730	COG4615	Cyclic peptide transporter
H4995_RS00750	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H4995_RS00755	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H4995_RS00765	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H4995_RS00775	COG0202	RNA polymerase activity
H4995_RS00780	COG0203	ribosomal protein L17
H4995_RS00805	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H4995_RS00820	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H4995_RS00820	COG0140	phosphoribosyl-ATP diphosphatase activity
H4995_RS00825	COG2171	N-acyltransferase activity
H4995_RS00830	COG0489	protein tyrosine kinase activity
H4995_RS00835	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H4995_RS00835	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H4995_RS00845	COG2046	Belongs to the sulfate adenylyltransferase family
H4995_RS00865	COG3842	ATPase activity
H4995_RS00895	COG0598	Magnesium transport protein CorA
H4995_RS00900	COG0521	Mo-molybdopterin cofactor biosynthetic process
H4995_RS00910	COG0501	Belongs to the peptidase M48B family
H4995_RS00915	COG2890	protein-(glutamine-N5) methyltransferase activity
H4995_RS00930	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H4995_RS00935	COG0587	DNA-directed DNA polymerase activity
H4995_RS00945	COG1393	Belongs to the ArsC family
H4995_RS00950	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H4995_RS00975	COG1837	Belongs to the UPF0109 family
H4995_RS00980	COG0228	four-way junction DNA binding
H4995_RS00985	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H4995_RS00990	COG0564	pseudouridine synthase activity
H4995_RS00995	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H4995_RS00995	COG1519	Transferase
H4995_RS01005	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H4995_RS01020	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H4995_RS01025	COG0826	peptidase U32
H4995_RS01045	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
H4995_RS01055	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H4995_RS01065	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H4995_RS01080	COG0019	diaminopimelate decarboxylase activity
H4995_RS01090	COG0193	aminoacyl-tRNA hydrolase activity
H4995_RS01095	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
H4995_RS01105	COG2076	Multidrug Resistance protein
H4995_RS01110	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H4995_RS01115	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H4995_RS01150	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H4995_RS01170	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H4995_RS01205	COG0515	serine threonine protein kinase
H4995_RS01205	COG2815	serine threonine protein kinase
H4995_RS01210	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H4995_RS01225	COG0835	chemotaxis
H4995_RS01225	COG0784	Response regulator, receiver
H4995_RS01230	COG0643	Histidine kinase
H4995_RS01230	COG2198	Histidine kinase
H4995_RS01230	COG0784	Response regulator, receiver
H4995_RS01235	COG0835	chemotaxis
H4995_RS01255	COG1629	transport
H4995_RS01255	COG4206	TonB-dependent receptor
H4995_RS01260	COG0811	peptide transport
H4995_RS01265	COG0848	biopolymer transport protein
H4995_RS01275	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H4995_RS01280	COG1253	flavin adenine dinucleotide binding
H4995_RS01290	COG2824	Alkylphosphonate utilization operon protein PhnA
H4995_RS01295	COG0861	Integral membrane protein TerC family
H4995_RS01300	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H4995_RS01305	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H4995_RS01305	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H4995_RS01315	COG0606	chelatase, subunit chli
H4995_RS01320	COG0242	peptide deformylase activity
H4995_RS01330	COG0544	peptidyl-prolyl cis-trans isomerase activity
H4995_RS01335	COG0302	gtp cyclohydrolase
H4995_RS01340	COG1157	protein secretion by the type III secretion system
H4995_RS01345	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H4995_RS01350	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
H4995_RS01355	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H4995_RS01355	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H4995_RS01380	COG2851	Citrate transporter
H4995_RS01385	COG1297	OPT oligopeptide transporter protein
H4995_RS01390	COG1968	undecaprenyl-diphosphatase activity
H4995_RS01400	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H4995_RS01455	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H4995_RS01460	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H4995_RS01465	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H4995_RS01480	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H4995_RS01500	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H4995_RS01505	COG0670	Belongs to the BI1 family
H4995_RS01510	COG0288	reversible hydration of carbon dioxide
H4995_RS01515	COG0668	transmembrane transport
H4995_RS01540	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H4995_RS01545	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H4995_RS01570	COG0477	Major facilitator Superfamily
H4995_RS01580	COG0315	cyclic pyranopterin monophosphate synthase activity
H4995_RS01585	COG2921	Belongs to the UPF0250 family
H4995_RS01595	COG0708	Exodeoxyribonuclease III
H4995_RS01600	COG2194	sulfuric ester hydrolase activity
H4995_RS01605	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H4995_RS01615	COG0418	dihydroorotase activity
H4995_RS01625	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
H4995_RS01665	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4995_RS01735	COG0675	Transposase, IS605 OrfB family
H4995_RS01750	COG0456	acetyltransferase
H4995_RS01835	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H4995_RS01875	COG3504	Conjugal transfer protein
H4995_RS01880	COG3736	Type IV secretory pathway, component VirB8
H4995_RS01905	COG0629	single-stranded DNA binding
H4995_RS01915	COG3646	Phage regulatory protein
H4995_RS01940	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
H4995_RS01960	COG1598	PFAM Uncharacterised protein family UPF0150
H4995_RS02000	COG2814	Major facilitator Superfamily
H4995_RS02060	COG1739	Uncharacterized protein family UPF0029
H4995_RS02075	COG0488	(ABC) transporter
H4995_RS02110	COG2353	YceI-like domain
H4995_RS02155	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H4995_RS02160	COG1053	succinate dehydrogenase
H4995_RS02180	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H4995_RS02195	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
H4995_RS02200	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
H4995_RS02235	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H4995_RS02240	COG0579	oxidoreductase
H4995_RS02260	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H4995_RS02290	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H4995_RS02310	COG0529	Catalyzes the synthesis of activated sulfate
H4995_RS02315	COG1213	nucleotidyl transferase
H4995_RS02320	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
H4995_RS02325	COG0574	Belongs to the PEP-utilizing enzyme family
H4995_RS02325	COG3848	Pyruvate phosphate dikinase
H4995_RS02330	COG2226	methyltransferase
H4995_RS02375	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H4995_RS02395	COG0137	argininosuccinate synthase activity
H4995_RS02400	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H4995_RS02405	COG0802	atpase or kinase
H4995_RS02410	COG1137	ATPase activity
H4995_RS02415	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H4995_RS02420	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H4995_RS02435	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H4995_RS02440	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
H4995_RS02450	COG0556	nucleotide-excision repair
H4995_RS02470	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H4995_RS02495	COG0330	HflC and HflK could
H4995_RS02505	COG1942	4-Oxalocrotonate Tautomerase
H4995_RS02510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H4995_RS02515	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H4995_RS02520	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
H4995_RS02530	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H4995_RS02535	COG1077	Cell shape determining protein MreB Mrl
H4995_RS02545	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H4995_RS02560	COG0783	Belongs to the Dps family
H4995_RS02570	COG2992	FlgJ-related protein
H4995_RS02580	COG0237	dephospho-CoA kinase activity
H4995_RS02585	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H4995_RS02595	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
H4995_RS02605	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H4995_RS02610	COG0303	'Molybdopterin
H4995_RS02615	COG0314	molybdopterin synthase activity
H4995_RS02645	COG3383	formate dehydrogenase (NAD+) activity
H4995_RS02655	COG0437	4 iron, 4 sulfur cluster binding
H4995_RS02665	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H4995_RS02700	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H4995_RS02705	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4995_RS02725	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H4995_RS02730	COG0583	DNA-binding transcription factor activity
H4995_RS02735	COG2855	membrane
H4995_RS02750	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H4995_RS02755	COG0113	porphobilinogen synthase activity
H4995_RS02760	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H4995_RS02770	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4995_RS02775	COG2181	nitrate reductase activity
H4995_RS02775	COG0247	lactate metabolic process
H4995_RS02790	COG2807	transmembrane transport
H4995_RS02795	COG1473	amidohydrolase
H4995_RS02800	COG3022	response to hydroperoxide
H4995_RS02810	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4995_RS02815	COG0477	Major facilitator Superfamily
H4995_RS02820	COG2195	Cleaves the N-terminal amino acid of tripeptides
H4995_RS02870	COG0824	Thioesterase
H4995_RS02890	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H4995_RS02910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H4995_RS02915	COG0772	Belongs to the SEDS family
H4995_RS02920	COG0439	Biotin carboxylase
H4995_RS02930	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H4995_RS02970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H4995_RS02985	COG2204	response regulator
H4995_RS02990	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H4995_RS03040	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H4995_RS03040	COG1333	cytochrome c biogenesis protein
H4995_RS03060	COG0343	queuine tRNA-ribosyltransferase activity
H4995_RS03085	COG1338	Plays a role in the flagellum-specific transport system
H4995_RS03090	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
H4995_RS03120	COG0101	tRNA pseudouridine synthase activity
H4995_RS03125	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H4995_RS03145	COG1757	Na H antiporter
H4995_RS03150	COG4221	oxidoreductase activity
H4995_RS03160	COG1049	propionate catabolic process, 2-methylcitrate cycle
H4995_RS03165	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H4995_RS03175	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4995_RS03175	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4995_RS03215	COG1560	Kdo2-lipid A biosynthetic process
H4995_RS03220	COG0859	PFAM glycosyl transferase family 9
H4995_RS03230	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H4995_RS03235	COG1132	(ABC) transporter
H4995_RS03240	COG0438	transferase activity, transferring glycosyl groups
H4995_RS03245	COG1215	transferase activity, transferring glycosyl groups
H4995_RS03250	COG0438	transferase activity, transferring glycosyl groups
H4995_RS03260	COG0438	transferase activity, transferring glycosyl groups
H4995_RS03265	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H4995_RS03270	COG0110	maltose O-acetyltransferase activity
H4995_RS03275	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H4995_RS03280	COG1086	Polysaccharide biosynthesis protein
H4995_RS03290	COG0745	RESPONSE REGULATOR receiver
H4995_RS03295	COG2264	protein methyltransferase activity
H4995_RS03300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4995_RS03310	COG1183	phosphatidylcholine synthase activity
H4995_RS03315	COG2833	Protein of unknown function (DUF455)
H4995_RS03320	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H4995_RS03325	COG2095	MarC family integral membrane protein
H4995_RS03335	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H4995_RS03340	COG0542	response to heat
H4995_RS03355	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H4995_RS03375	COG0210	DNA helicase
H4995_RS03395	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H4995_RS03400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H4995_RS03405	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H4995_RS03410	COG1862	Preprotein translocase
H4995_RS03415	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4995_RS03420	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H4995_RS03440	COG0285	dihydrofolate synthase activity
H4995_RS03445	COG0739	heme binding
H4995_RS03475	COG0849	cell division
H4995_RS03480	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H4995_RS03485	COG4786	Flagellar basal body rod
H4995_RS03490	COG4786	Flagellar basal body rod
H4995_RS03495	COG0174	glutamine synthetase
H4995_RS03500	COG0305	Participates in initiation and elongation during chromosome replication
H4995_RS03515	COG0492	ferredoxin-NADP+ reductase activity
H4995_RS03520	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H4995_RS03525	COG1289	transmembrane transporter activity
H4995_RS03555	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H4995_RS03575	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H4995_RS03585	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H4995_RS03590	COG0181	hydroxymethylbilane synthase activity
H4995_RS03600	COG0442	prolyl-tRNA aminoacylation
H4995_RS03605	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H4995_RS03610	COG0142	geranyltranstransferase activity
H4995_RS03630	COG1013	pyruvate-flavodoxin oxidoreductase activity
H4995_RS03635	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H4995_RS03635	COG0674	pyruvate-flavodoxin oxidoreductase activity
H4995_RS03645	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H4995_RS03655	COG0039	L-malate dehydrogenase activity
H4995_RS03670	COG1192	Involved in chromosome partitioning
H4995_RS03675	COG1475	DNA binding
H4995_RS03690	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H4995_RS03705	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H4995_RS03710	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H4995_RS03715	COG0811	peptide transport
H4995_RS03720	COG0848	biopolymer transport protein
H4995_RS03730	COG0823	Involved in the tonB-independent uptake of proteins
H4995_RS03735	COG2885	chlorophyll binding
H4995_RS03745	COG1047	Peptidyl-prolyl cis-trans
H4995_RS03750	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
H4995_RS03755	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H4995_RS03760	COG0037	tRNA processing
H4995_RS03785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H4995_RS03795	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H4995_RS03805	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H4995_RS03815	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H4995_RS03830	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
H4995_RS03840	COG0083	homoserine kinase activity
H4995_RS03850	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
H4995_RS03865	COG1401	restriction endodeoxyribonuclease activity
H4995_RS03875	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H4995_RS03880	COG1121	(ABC) transporter
H4995_RS03895	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H4995_RS03910	COG1028	Short-chain dehydrogenase reductase Sdr
H4995_RS03920	COG1053	succinate dehydrogenase
H4995_RS03925	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H4995_RS03930	COG2048	Heterodisulfide reductase, subunit B
H4995_RS03935	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H4995_RS03940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H4995_RS03945	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H4995_RS03975	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H4995_RS03980	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H4995_RS04010	COG2121	Domain of unknown function (DUF374)
H4995_RS04025	COG0195	Participates in both transcription termination and antitermination
H4995_RS04035	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H4995_RS04040	COG0612	Peptidase, M16
H4995_RS04045	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H4995_RS04050	COG2346	COG2346, Truncated hemoglobins
H4995_RS04065	COG0765	amino acid transport
H4995_RS04085	COG0586	Pfam SNARE associated Golgi protein
H4995_RS04090	COG0039	L-malate dehydrogenase activity
H4995_RS04100	COG3610	response to peptide
H4995_RS04120	COG2217	Heavy metal translocating P-type atpase
H4995_RS04130	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H4995_RS04135	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H4995_RS04140	COG2217	Heavy metal translocating P-type atpase
H4995_RS04155	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H4995_RS04180	COG1216	Glycosyl transferase, family 2
H4995_RS04200	COG0628	permease
H4995_RS04205	COG0114	fumarate hydratase activity
H4995_RS04215	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H4995_RS04225	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H4995_RS04230	COG2252	PERMEase
H4995_RS04240	COG2853	Lipoprotein
H4995_RS04260	COG2814	Major facilitator Superfamily
H4995_RS04275	COG3276	selenocysteine insertion sequence binding
H4995_RS04310	COG1684	flagellar biosynthetic protein fliR
H4995_RS04320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H4995_RS04325	COG0052	Belongs to the universal ribosomal protein uS2 family
H4995_RS04330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H4995_RS04340	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H4995_RS04345	COG0723	plastoquinol--plastocyanin reductase activity
H4995_RS04350	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H4995_RS04355	COG0445	tRNA wobble uridine modification
H4995_RS04375	COG1301	dicarboxylic acid transport
H4995_RS04390	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H4995_RS04425	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H4995_RS04435	COG0356	it plays a direct role in the translocation of protons across the membrane
H4995_RS04440	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H4995_RS04445	COG0552	protein localization to endoplasmic reticulum
H4995_RS04485	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H4995_RS04490	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H4995_RS04505	COG0250	Participates in transcription elongation, termination and antitermination
H4995_RS04510	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H4995_RS04515	COG0081	regulation of translation
H4995_RS04520	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H4995_RS04525	COG0222	ribosome binding
H4995_RS04545	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4995_RS04555	COG2721	sulfolactate sulfo-lyase activity
H4995_RS04560	COG2271	Major facilitator Superfamily
H4995_RS04565	COG1028	Short-chain dehydrogenase reductase Sdr
H4995_RS04570	COG0738	Major facilitator superfamily
H4995_RS04580	COG3254	rhamnose metabolic process
H4995_RS04585	COG1012	belongs to the aldehyde dehydrogenase family
H4995_RS04590	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H4995_RS04595	COG0049	tRNA binding
H4995_RS04640	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H4995_RS04645	COG0004	ammonium transporteR
H4995_RS04655	COG0673	inositol 2-dehydrogenase activity
H4995_RS04670	COG0424	maF-like protein
H4995_RS04680	COG0542	response to heat
H4995_RS04685	COG1937	Protein conserved in bacteria
H4995_RS04690	COG0793	Belongs to the peptidase S41A family
H4995_RS04695	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H4995_RS04700	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H4995_RS04705	COG0047	phosphoribosylformylglycinamidine synthase activity
H4995_RS04715	COG0204	Acyl-transferase
H4995_RS04730	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H4995_RS04750	COG1677	Flagellar hook-basal body complex protein FliE
H4995_RS04755	COG1558	bacterial-type flagellum-dependent cell motility
H4995_RS04760	COG1815	bacterial-type flagellum-dependent cell motility
H4995_RS04780	COG1987	bacterial-type flagellum assembly
H4995_RS04785	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
H4995_RS04790	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H4995_RS04795	COG0148	phosphopyruvate hydratase activity
H4995_RS04810	COG1793	dna ligase
H4995_RS04860	COG1136	(ABC) transporter
H4995_RS04885	COG0672	)-iron permease
H4995_RS04895	COG2165	general secretion pathway protein
H4995_RS04900	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H4995_RS04910	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H4995_RS04915	COG0575	Belongs to the CDS family
H4995_RS04925	COG1293	RNA-binding protein homologous to eukaryotic snRNP
H4995_RS04935	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
H4995_RS04940	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4995_RS04945	COG4605	iron ion homeostasis
H4995_RS04950	COG4604	ABC transporter, ATP-binding protein
H4995_RS04955	COG4607	ABC-type enterochelin transport system periplasmic component
H4995_RS04970	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H4995_RS04975	COG3005	denitrification pathway
H4995_RS05040	COG0322	excinuclease ABC activity
H4995_RS05050	COG0731	radical SAM domain protein
H4995_RS05065	COG2814	Major facilitator Superfamily
H4995_RS05085	COG0248	Ppx GppA phosphatase
H4995_RS05095	COG0739	heme binding
H4995_RS05100	COG0751	glycine-tRNA ligase activity
H4995_RS05105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
H4995_RS05115	COG0475	glutathione-regulated potassium exporter activity
H4995_RS05115	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H4995_RS05120	COG0789	Transcriptional regulator
H4995_RS05125	COG0484	heat shock protein binding
H4995_RS05130	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H4995_RS05135	COG0745	RESPONSE REGULATOR receiver
H4995_RS05140	COG0642	Histidine kinase
H4995_RS05160	COG0745	RESPONSE REGULATOR receiver
H4995_RS05175	COG1139	Iron-sulfur cluster binding protein
H4995_RS05180	COG0247	lactate metabolic process
H4995_RS05195	COG3021	interspecies interaction between organisms
H4995_RS05210	COG1271	oxidase subunit
H4995_RS05215	COG1294	oxidase, subunit
H4995_RS05220	COG1794	racemase activity, acting on amino acids and derivatives
H4995_RS05230	COG1027	Aspartate ammonia-lyase
H4995_RS05235	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H4995_RS05265	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H4995_RS05270	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H4995_RS05300	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H4995_RS05315	COG0564	pseudouridine synthase activity
H4995_RS05320	COG0772	Belongs to the SEDS family
H4995_RS05335	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H4995_RS05340	COG0569	domain protein
H4995_RS05345	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
H4995_RS05350	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H4995_RS05355	COG0280	phosphate acetyltransferase
H4995_RS05355	COG0281	malic enzyme
H4995_RS05370	COG0439	Biotin carboxylase
H4995_RS05375	COG0511	ligase activity, forming carbon-carbon bonds
H4995_RS05385	COG1086	Polysaccharide biosynthesis protein
H4995_RS05390	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H4995_RS05410	COG0581	inorganic phosphate transmembrane transporter activity
H4995_RS05415	COG0573	inorganic phosphate transmembrane transporter activity
H4995_RS05420	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H4995_RS05425	COG1528	Iron-storage protein
H4995_RS05430	COG1696	Membrane protein involved in D-alanine export
H4995_RS05445	COG1538	Outer membrane efflux protein
H4995_RS05450	COG1136	(ABC) transporter
H4995_RS05450	COG0577	efflux transmembrane transporter activity
H4995_RS05455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4995_RS05460	COG1473	amidohydrolase
H4995_RS05480	COG0733	neurotransmitter:sodium symporter activity
H4995_RS05500	COG0191	fructose-bisphosphate aldolase activity
H4995_RS05505	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H4995_RS05510	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H4995_RS05520	COG2860	membrane
H4995_RS05535	COG2890	protein-(glutamine-N5) methyltransferase activity
H4995_RS05540	COG0196	riboflavin kinase activity
H4995_RS05560	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H4995_RS05575	COG0527	aspartate kinase activity
H4995_RS05580	COG0494	nUDIX hydrolase
H4995_RS05585	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4995_RS05595	COG0805	protein transport
H4995_RS05600	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H4995_RS05610	COG0440	acetolactate synthase activity
H4995_RS05615	COG0028	Belongs to the TPP enzyme family
H4995_RS05620	COG1610	YqeY-like protein
H4995_RS05625	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H4995_RS05625	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H4995_RS05650	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H4995_RS05655	COG0425	Belongs to the sulfur carrier protein TusA family
H4995_RS05670	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H4995_RS05690	COG0505	Belongs to the CarA family
H4995_RS05705	COG0745	RESPONSE REGULATOR receiver
H4995_RS05755	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H4995_RS05760	COG1126	abc transporter atp-binding protein
H4995_RS05765	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H4995_RS05770	COG0765	amino acid transport
H4995_RS05775	COG0765	amino acid transport
H4995_RS05780	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H4995_RS05785	COG1966	Carbon starvation protein
H4995_RS05805	COG0776	regulation of translation
H4995_RS05810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H4995_RS05815	COG1999	signal sequence binding
H4995_RS05840	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H4995_RS05845	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H4995_RS05850	COG1115	amino acid carrier protein
H4995_RS05860	COG0765	amino acid transport
H4995_RS05875	COG0537	adenosine 5'-monophosphoramidase activity
H4995_RS05880	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H4995_RS05885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H4995_RS05885	COG0072	phenylalanine-tRNA ligase activity
H4995_RS05890	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
H4995_RS05900	COG0539	negative regulation of cytoplasmic translation
H4995_RS05900	COG1185	polyribonucleotide nucleotidyltransferase activity
H4995_RS05910	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H4995_RS05915	COG0745	RESPONSE REGULATOR receiver
H4995_RS05920	COG5002	protein histidine kinase activity
H4995_RS05925	COG0488	(ABC) transporter
H4995_RS05940	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H4995_RS05960	COG1295	ribonuclease BN
H4995_RS05965	COG0277	FAD linked oxidase domain protein
H4995_RS05975	COG0739	heme binding
H4995_RS05985	COG1496	oxidoreductase activity
H4995_RS06000	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H4995_RS06025	COG0492	ferredoxin-NADP+ reductase activity
H4995_RS06030	COG3118	belongs to the thioredoxin family
H4995_RS06035	COG0792	nuclease activity
H4995_RS06040	COG0460	homoserine dehydrogenase
H4995_RS06045	COG0436	Aminotransferase
H4995_RS06060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H4995_RS06065	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H4995_RS06070	COG0254	rRNA binding
H4995_RS06075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H4995_RS06095	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H4995_RS06100	COG4773	Receptor
H4995_RS06105	COG0484	heat shock protein binding
H4995_RS06110	COG0745	RESPONSE REGULATOR receiver
H4995_RS06115	COG0642	Histidine kinase
H4995_RS06120	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H4995_RS06125	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H4995_RS06130	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
H4995_RS06135	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
H4995_RS06140	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H4995_RS06145	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H4995_RS06145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H4995_RS06160	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H4995_RS06165	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H4995_RS06170	COG1758	RNA polymerase activity
H4995_RS06175	COG0528	UMP kinase activity
H4995_RS06190	COG1217	gtp-binding protein TYPA
H4995_RS06205	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H4995_RS06220	COG0745	RESPONSE REGULATOR receiver
H4995_RS06225	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H4995_RS06240	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H4995_RS06240	COG1776	CheC inhibitor of MCP methylation
H4995_RS06255	COG0133	tryptophan synthase activity
H4995_RS06265	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H4995_RS06265	COG0512	Glutamine amidotransferase of anthranilate synthase
H4995_RS06280	COG0730	response to heat
H4995_RS06285	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H4995_RS06290	COG1238	metal cluster binding
H4995_RS06310	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H4995_RS06315	COG1360	Flagellar Motor Protein
H4995_RS06320	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H4995_RS06355	COG0280	phosphate acetyltransferase
H4995_RS06365	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H4995_RS06375	COG0166	Belongs to the GPI family
H4995_RS06385	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H4995_RS06390	COG3839	Belongs to the ABC transporter superfamily
H4995_RS06395	COG4662	Binding-protein-dependent transport system inner membrane component
H4995_RS06400	COG2998	abc-type tungstate transport system, permease component
H4995_RS06405	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
H4995_RS06410	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H4995_RS06415	COG1984	allophanate hydrolase subunit 2
H4995_RS06425	COG2249	NAD(P)H dehydrogenase (quinone) activity
H4995_RS06430	COG1733	regulation of RNA biosynthetic process
H4995_RS06440	COG1064	alcohol dehydrogenase
H4995_RS06455	COG0732	type I restriction modification DNA specificity domain
H4995_RS06495	COG0640	Transcriptional regulator
H4995_RS06505	COG0798	PFAM Bile acid sodium symporter
H4995_RS06525	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H4995_RS06535	COG0791	NLP P60 protein
H4995_RS06540	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H4995_RS06545	COG0024	Methionine aminopeptidase
H4995_RS06555	COG3218	ABC-type transport auxiliary lipoprotein component
H4995_RS06555	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H4995_RS06565	COG1127	ABC transporter
H4995_RS06570	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H4995_RS06575	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H4995_RS06590	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H4995_RS06595	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H4995_RS06625	COG0706	membrane insertase activity
H4995_RS06635	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H4995_RS06645	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H4995_RS06650	COG0138	bifunctional purine biosynthesis protein purh
H4995_RS06680	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H4995_RS06705	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H4995_RS06710	COG0653	protein targeting
H4995_RS06720	COG1215	transferase activity, transferring glycosyl groups
H4995_RS06720	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
H4995_RS06730	COG0517	IMP dehydrogenase activity
H4995_RS06730	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H4995_RS06775	COG0037	tRNA processing
H4995_RS06780	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H4995_RS06785	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H4995_RS06800	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H4995_RS06825	COG3951	Flagellar rod assembly protein muramidase FlgJ
H4995_RS06850	COG0730	response to heat
H4995_RS06855	COG1459	type II secretion system
H4995_RS06860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
H4995_RS06895	COG1028	Short-chain dehydrogenase reductase Sdr
H4995_RS06900	COG1083	cytidylyl-transferase
H4995_RS06910	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H4995_RS06915	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
H4995_RS06920	COG2089	acid synthase
H4995_RS06930	COG0268	Binds directly to 16S ribosomal RNA
H4995_RS06935	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H4995_RS06940	COG0748	coenzyme F420 binding
H4995_RS06950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H4995_RS06955	COG1120	ATPase activity
H4995_RS06960	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H4995_RS06970	COG0477	Major facilitator Superfamily
H4995_RS06975	COG1194	a g-specific adenine glycosylase
H4995_RS07005	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4995_RS07005	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
H4995_RS07015	COG1760	l-serine dehydratase
H4995_RS07020	COG0814	amino acid
H4995_RS07035	COG0811	peptide transport
H4995_RS07040	COG0848	biopolymer transport protein
H4995_RS07065	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H4995_RS07075	COG0328	RNA-DNA hybrid ribonuclease activity
H4995_RS07100	COG1971	Probably functions as a manganese efflux pump
H4995_RS07125	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H4995_RS07130	COG0602	queuosine metabolic process
H4995_RS07140	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H4995_RS07160	COG1840	ABC-type Fe3 transport system, periplasmic component
H4995_RS07180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H4995_RS07185	COG2011	ABC-type metal ion transport system permease component
H4995_RS07190	COG1464	Belongs to the NlpA lipoprotein family
H4995_RS07195	COG1464	Belongs to the NlpA lipoprotein family
H4995_RS07200	COG1464	Belongs to the NlpA lipoprotein family
H4995_RS07210	COG0163	prenyltransferase activity
H4995_RS07215	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H4995_RS07230	COG1166	arginine decarboxylase activity
H4995_RS07235	COG1045	serine acetyltransferase
H4995_RS07240	COG0436	Aminotransferase
H4995_RS07260	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H4995_RS07265	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
H4995_RS07270	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H4995_RS07290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H4995_RS07295	COG0754	glutathionylspermidine amidase activity
H4995_RS07305	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H4995_RS07320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H4995_RS07330	COG1538	Outer membrane efflux protein
H4995_RS07340	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H4995_RS07345	COG1981	membrane
H4995_RS07350	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H4995_RS07370	COG1193	negative regulation of DNA recombination
H4995_RS07400	COG0516	GMP reductase activity
H4995_RS07400	COG0517	IMP dehydrogenase activity
H4995_RS07410	COG0110	maltose O-acetyltransferase activity
H4995_RS07425	COG2089	acid synthase
H4995_RS07435	COG0733	neurotransmitter:sodium symporter activity
H4995_RS07440	COG0733	neurotransmitter:sodium symporter activity
H4995_RS07445	COG5016	pyruvate
H4995_RS07445	COG0511	ligase activity, forming carbon-carbon bonds
H4995_RS07450	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H4995_RS07455	COG0165	Argininosuccinate lyase
H4995_RS07460	COG0012	GTP binding
H4995_RS07465	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H4995_RS07505	COG4771	TonB-dependent receptor
H4995_RS07510	COG1420	regulation of RNA biosynthetic process
H4995_RS07565	COG0105	UTP biosynthetic process
H4995_RS07575	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H4995_RS07580	COG0416	fatty acid biosynthetic process
H4995_RS07585	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4995_RS07595	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H4995_RS07600	COG1570	exodeoxyribonuclease VII activity
H4995_RS07605	COG2226	methyltransferase
H4995_RS07615	COG0753	catalase activity
H4995_RS07625	COG2964	Protein conserved in bacteria
H4995_RS07630	COG0251	oxidation-reduction process
H4995_RS07655	COG1918	ferrous iron import across plasma membrane
H4995_RS07660	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H4995_RS07665	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H4995_RS07670	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H4995_RS07685	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H4995_RS07710	COG1580	Controls the rotational direction of flagella during chemotaxis
H4995_RS07725	COG2124	cytochrome p450
H4995_RS07745	COG1442	glycosyl transferase family 8
H4995_RS07745	COG1216	Glycosyl transferase, family 2
H4995_RS07755	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4995_RS07765	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H4995_RS07770	COG1419	protein localization to endoplasmic reticulum
H4995_RS07775	COG0455	bacterial-type flagellum organization
H4995_RS07785	COG1191	sigma factor activity
H4995_RS07790	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H4995_RS07795	COG1776	CheC inhibitor of MCP methylation
H4995_RS07795	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H4995_RS07835	COG0471	metal ion transport
H4995_RS07840	COG0471	metal ion transport
H4995_RS07865	COG1674	ftsk spoiiie
H4995_RS07865	COG1196	nuclear chromosome segregation
H4995_RS07870	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H4995_RS07875	COG1959	2 iron, 2 sulfur cluster binding
H4995_RS07880	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H4995_RS07885	COG2404	hydrolase activity, acting on ester bonds
H4995_RS07940	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H4995_RS07950	COG0582	viral genome integration into host DNA
H4995_RS07955	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H4995_RS07960	COG0512	Glutamine amidotransferase of anthranilate synthase
H4995_RS07960	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H4995_RS07975	COG0303	'Molybdopterin
H4995_RS07980	COG0681	Belongs to the peptidase S26 family
H4995_RS07985	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H4995_RS08020	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H4995_RS08025	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H4995_RS08030	COG1663	tetraacyldisaccharide 4'-kinase activity
H4995_RS08035	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H4995_RS08050	COG1028	Short-chain dehydrogenase reductase Sdr
H4995_RS08055	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
H4995_RS08060	COG0612	Peptidase, M16
H4995_RS08065	COG0167	dihydroorotate dehydrogenase activity
H4995_RS08070	COG1132	(ABC) transporter
H4995_RS08075	COG0215	cysteine-tRNA ligase activity
H4995_RS08090	COG0546	phosphoglycolate phosphatase activity
H4995_RS08100	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H4995_RS08105	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H4995_RS08110	COG0210	DNA helicase
H4995_RS08120	COG0375	protein maturation
H4995_RS08125	COG0309	Hydrogenase expression formation protein (HypE)
H4995_RS08130	COG0409	Hydrogenase expression formation protein
H4995_RS08135	COG0298	carbon dioxide binding
H4995_RS08145	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H4995_RS08160	COG0534	Mate efflux family protein
H4995_RS08180	COG0557	exoribonuclease II activity
H4995_RS08195	COG0758	DNA mediated transformation
H4995_RS08215	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H4995_RS08225	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H4995_RS08235	COG0497	DNA recombination
H4995_RS08245	COG0084	hydrolase, TatD family'
H4995_RS08250	COG1388	LysM domain
H4995_RS08250	COG0791	NLP P60 protein
H4995_RS08255	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H4995_RS08285	COG0352	thiamine-phosphate diphosphorylase activity
H4995_RS08290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H4995_RS08350	COG1181	Belongs to the D-alanine--D-alanine ligase family
H4995_RS08355	COG0632	four-way junction helicase activity
H4995_RS08375	COG0463	Glycosyl transferase, family 2
H4995_RS08380	COG1216	Glycosyl transferase, family 2
H4995_RS08380	COG1442	glycosyl transferase family 8
H4995_RS08390	COG1216	Glycosyl transferase, family 2
H4995_RS08390	COG1442	glycosyl transferase family 8
H4995_RS08425	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H4995_RS08455	COG1408	metallophosphoesterase
H4995_RS08460	COG0688	phosphatidylethanolamine metabolic process
H4995_RS08490	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H4995_RS08515	COG0765	amino acid transport
H4995_RS08530	COG0788	formyltetrahydrofolate deformylase activity
H4995_RS08535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H4995_RS08545	COG0642	Histidine kinase
H4995_RS08555	COG2089	acid synthase
H4995_RS08570	COG0107	imidazoleglycerol-phosphate synthase activity
H4995_RS08575	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
H4995_RS08580	COG3980	spore coat polysaccharide biosynthesis protein
H4995_RS08585	COG1083	cytidylyl-transferase
H4995_RS08620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H4995_RS08665	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H4995_RS08670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H4995_RS08680	COG0616	signal peptide processing
H4995_RS08700	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H4995_RS08705	COG0217	transcriptional regulatory protein
H4995_RS08720	COG0018	arginyl-trna synthetase
H4995_RS08725	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H4995_RS08730	COG0194	GDP metabolic process
H4995_RS08745	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H4995_RS08810	COG0757	Catalyzes a trans-dehydration via an enolate intermediate