locus-tag	class	description
AEI01_RS00010	COG0484	heat shock protein binding
AEI01_RS00025	COG1333	cytochrome c biogenesis protein
AEI01_RS00025	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AEI01_RS00030	COG0405	Gamma-glutamyltransferase
AEI01_RS00050	COG2814	Major facilitator Superfamily
AEI01_RS00070	COG1217	gtp-binding protein TYPA
AEI01_RS00085	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
AEI01_RS00115	COG0471	metal ion transport
AEI01_RS00130	COG0471	metal ion transport
AEI01_RS00140	COG1611	Belongs to the LOG family
AEI01_RS00145	COG1776	CheC inhibitor of MCP methylation
AEI01_RS00145	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AEI01_RS00150	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AEI01_RS00155	COG1191	sigma factor activity
AEI01_RS00165	COG0455	bacterial-type flagellum organization
AEI01_RS00170	COG1419	protein localization to endoplasmic reticulum
AEI01_RS00175	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
AEI01_RS00180	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
AEI01_RS00185	COG0402	S-adenosylhomocysteine deaminase activity
AEI01_RS00190	COG0616	signal peptide processing
AEI01_RS00205	COG2703	oxygen carrier activity
AEI01_RS00220	COG1139	Iron-sulfur cluster binding protein
AEI01_RS00225	COG0247	lactate metabolic process
AEI01_RS00240	COG3021	interspecies interaction between organisms
AEI01_RS00255	COG1271	oxidase subunit
AEI01_RS00260	COG1294	oxidase, subunit
AEI01_RS00265	COG1794	racemase activity, acting on amino acids and derivatives
AEI01_RS00275	COG1027	Aspartate ammonia-lyase
AEI01_RS00280	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AEI01_RS00310	COG0261	This protein binds to 23S rRNA in the presence of protein L20
AEI01_RS00315	COG0211	Belongs to the bacterial ribosomal protein bL27 family
AEI01_RS00335	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
AEI01_RS00335	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
AEI01_RS00340	COG1192	Involved in chromosome partitioning
AEI01_RS00345	COG1475	DNA binding
AEI01_RS00355	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
AEI01_RS00375	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
AEI01_RS00385	COG0811	peptide transport
AEI01_RS00390	COG0848	biopolymer transport protein
AEI01_RS00405	COG2885	chlorophyll binding
AEI01_RS00415	COG1047	Peptidyl-prolyl cis-trans
AEI01_RS00420	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
AEI01_RS00425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
AEI01_RS00430	COG0037	tRNA processing
AEI01_RS00460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
AEI01_RS00470	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
AEI01_RS00480	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
AEI01_RS00490	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
AEI01_RS00555	COG1108	ABC-type Mn2 Zn2 transport systems permease components
AEI01_RS00560	COG1121	(ABC) transporter
AEI01_RS00590	COG0492	ferredoxin-NADP+ reductase activity
AEI01_RS00595	COG3118	belongs to the thioredoxin family
AEI01_RS00600	COG0792	nuclease activity
AEI01_RS00605	COG0460	homoserine dehydrogenase
AEI01_RS00610	COG0436	Aminotransferase
AEI01_RS00625	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
AEI01_RS00630	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
AEI01_RS00635	COG0254	rRNA binding
AEI01_RS00640	COG1385	rRNA (uridine-N3-)-methyltransferase activity
AEI01_RS00660	COG0602	queuosine metabolic process
AEI01_RS00665	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
AEI01_RS00690	COG1971	Probably functions as a manganese efflux pump
AEI01_RS00705	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
AEI01_RS00715	COG3842	ATPase activity
AEI01_RS00725	COG1840	ABC-type Fe3 transport system, periplasmic component
AEI01_RS00735	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
AEI01_RS00740	COG1253	flavin adenine dinucleotide binding
AEI01_RS00750	COG2824	Alkylphosphonate utilization operon protein PhnA
AEI01_RS00755	COG0861	Integral membrane protein TerC family
AEI01_RS00760	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
AEI01_RS00765	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
AEI01_RS00765	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
AEI01_RS00775	COG0606	chelatase, subunit chli
AEI01_RS00780	COG0242	peptide deformylase activity
AEI01_RS00800	COG1157	protein secretion by the type III secretion system
AEI01_RS00805	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
AEI01_RS00815	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
AEI01_RS00815	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
AEI01_RS00860	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
AEI01_RS00915	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
AEI01_RS00920	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
AEI01_RS00935	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AEI01_RS00955	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
AEI01_RS00960	COG0670	Belongs to the BI1 family
AEI01_RS00965	COG0288	reversible hydration of carbon dioxide
AEI01_RS00970	COG0668	transmembrane transport
AEI01_RS00995	COG0291	Belongs to the bacterial ribosomal protein bL35 family
AEI01_RS01005	COG0840	transmembrane signaling receptor activity
AEI01_RS01005	COG3290	protein histidine kinase activity
AEI01_RS01030	COG0477	Major facilitator Superfamily
AEI01_RS01045	COG2921	Belongs to the UPF0250 family
AEI01_RS01055	COG0708	Exodeoxyribonuclease III
AEI01_RS01060	COG2194	sulfuric ester hydrolase activity
AEI01_RS01065	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
AEI01_RS01075	COG0418	dihydroorotase activity
AEI01_RS01085	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
AEI01_RS01100	COG0428	transporter
AEI01_RS01105	COG0243	molybdopterin cofactor binding
AEI01_RS01125	COG0330	HflC and HflK could
AEI01_RS01135	COG1942	4-Oxalocrotonate Tautomerase
AEI01_RS01140	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
AEI01_RS01145	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
AEI01_RS01155	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
AEI01_RS01160	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
AEI01_RS01165	COG1077	Cell shape determining protein MreB Mrl
AEI01_RS01175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
AEI01_RS01195	COG0835	chemotaxis
AEI01_RS01200	COG0784	Response regulator, receiver
AEI01_RS01200	COG2198	Histidine kinase
AEI01_RS01200	COG0643	Histidine kinase
AEI01_RS01205	COG0784	Response regulator, receiver
AEI01_RS01205	COG0835	chemotaxis
AEI01_RS01215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
AEI01_RS01240	COG2189	Belongs to the N(4) N(6)-methyltransferase family
AEI01_RS01270	COG0454	-acetyltransferase
AEI01_RS01315	COG4106	trans-aconitate 2-methyltransferase activity
AEI01_RS01320	COG2830	Protein of unknown function (DUF452)
AEI01_RS01330	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
AEI01_RS01335	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
AEI01_RS01340	COG2076	Multidrug Resistance protein
AEI01_RS01365	COG0019	diaminopimelate decarboxylase activity
AEI01_RS01390	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AEI01_RS01430	COG0251	oxidation-reduction process
AEI01_RS01445	COG0333	Belongs to the bacterial ribosomal protein bL32 family
AEI01_RS01465	COG0450	alkyl hydroperoxide reductase
AEI01_RS01470	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AEI01_RS01475	COG1360	Flagellar Motor Protein
AEI01_RS01480	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
AEI01_RS01490	COG0477	Major facilitator Superfamily
AEI01_RS01500	COG1238	metal cluster binding
AEI01_RS01505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
AEI01_RS01510	COG0730	response to heat
AEI01_RS01525	COG0512	Glutamine amidotransferase of anthranilate synthase
AEI01_RS01525	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AEI01_RS01535	COG0133	tryptophan synthase activity
AEI01_RS01550	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
AEI01_RS01550	COG1776	CheC inhibitor of MCP methylation
AEI01_RS01565	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
AEI01_RS01570	COG0745	RESPONSE REGULATOR receiver
AEI01_RS01600	COG1981	membrane
AEI01_RS01605	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AEI01_RS01615	COG1538	Outer membrane efflux protein
AEI01_RS01625	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AEI01_RS01640	COG0828	Belongs to the bacterial ribosomal protein bS21 family
AEI01_RS01655	COG0754	glutathionylspermidine amidase activity
AEI01_RS01660	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
AEI01_RS01680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AEI01_RS01685	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
AEI01_RS01690	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
AEI01_RS01695	COG0284	orotidine-5'-phosphate decarboxylase activity
AEI01_RS01700	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
AEI01_RS01705	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
AEI01_RS01725	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
AEI01_RS01755	COG0579	oxidoreductase
AEI01_RS01760	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
AEI01_RS01780	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
AEI01_RS01815	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
AEI01_RS01835	COG1053	succinate dehydrogenase
AEI01_RS01840	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AEI01_RS01920	COG0488	(ABC) transporter
AEI01_RS01935	COG1739	Uncharacterized protein family UPF0029
AEI01_RS01995	COG1028	Short-chain dehydrogenase reductase Sdr
AEI01_RS02005	COG1053	succinate dehydrogenase
AEI01_RS02010	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
AEI01_RS02015	COG2048	Heterodisulfide reductase, subunit B
AEI01_RS02020	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
AEI01_RS02025	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
AEI01_RS02030	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
AEI01_RS02040	COG4771	TonB-dependent receptor
AEI01_RS02060	COG0227	Belongs to the bacterial ribosomal protein bL28 family
AEI01_RS02065	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
AEI01_RS02075	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
AEI01_RS02095	COG2121	Domain of unknown function (DUF374)
AEI01_RS02110	COG0195	Participates in both transcription termination and antitermination
AEI01_RS02120	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AEI01_RS02125	COG0612	Peptidase, M16
AEI01_RS02130	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
AEI01_RS02135	COG2346	COG2346, Truncated hemoglobins
AEI01_RS02140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
AEI01_RS02145	COG0765	amino acid transport
AEI01_RS02150	COG0765	amino acid transport
AEI01_RS02180	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
AEI01_RS02185	COG0267	Belongs to the bacterial ribosomal protein bL33 family
AEI01_RS02200	COG0250	Participates in transcription elongation, termination and antitermination
AEI01_RS02205	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
AEI01_RS02210	COG0081	regulation of translation
AEI01_RS02220	COG0222	ribosome binding
AEI01_RS02225	COG0085	RNA polymerase activity
AEI01_RS02240	COG0049	tRNA binding
AEI01_RS02285	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
AEI01_RS02320	COG0673	inositol 2-dehydrogenase activity
AEI01_RS02345	COG0542	response to heat
AEI01_RS02350	COG1937	Protein conserved in bacteria
AEI01_RS02355	COG0793	Belongs to the peptidase S41A family
AEI01_RS02360	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
AEI01_RS02365	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
AEI01_RS02370	COG0047	phosphoribosylformylglycinamidine synthase activity
AEI01_RS02380	COG0204	Acyl-transferase
AEI01_RS02395	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
AEI01_RS02415	COG1677	Flagellar hook-basal body complex protein FliE
AEI01_RS02420	COG1558	bacterial-type flagellum-dependent cell motility
AEI01_RS02425	COG1815	bacterial-type flagellum-dependent cell motility
AEI01_RS02445	COG0039	L-malate dehydrogenase activity
AEI01_RS02455	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
AEI01_RS02465	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
AEI01_RS02465	COG0674	pyruvate-flavodoxin oxidoreductase activity
AEI01_RS02470	COG1013	pyruvate-flavodoxin oxidoreductase activity
AEI01_RS02490	COG0142	geranyltranstransferase activity
AEI01_RS02510	COG0181	hydroxymethylbilane synthase activity
AEI01_RS02515	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
AEI01_RS02525	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
AEI01_RS02545	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
AEI01_RS02575	COG1289	transmembrane transporter activity
AEI01_RS02580	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
AEI01_RS02585	COG0492	ferredoxin-NADP+ reductase activity
AEI01_RS02600	COG0305	Participates in initiation and elongation during chromosome replication
AEI01_RS02655	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AEI01_RS02655	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AEI01_RS02660	COG1610	YqeY-like protein
AEI01_RS02665	COG0028	Belongs to the TPP enzyme family
AEI01_RS02670	COG0440	acetolactate synthase activity
AEI01_RS02685	COG0805	protein transport
AEI01_RS02695	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AEI01_RS02700	COG0494	nUDIX hydrolase
AEI01_RS02705	COG0527	aspartate kinase activity
AEI01_RS02720	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
AEI01_RS02740	COG0196	riboflavin kinase activity
AEI01_RS02760	COG2860	membrane
AEI01_RS02770	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
AEI01_RS02775	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AEI01_RS02780	COG0191	fructose-bisphosphate aldolase activity
AEI01_RS02800	COG0733	neurotransmitter:sodium symporter activity
AEI01_RS02805	COG2258	MOSC domain
AEI01_RS02820	COG1473	amidohydrolase
AEI01_RS02825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
AEI01_RS02830	COG0577	efflux transmembrane transporter activity
AEI01_RS02830	COG1136	(ABC) transporter
AEI01_RS02835	COG1538	Outer membrane efflux protein
AEI01_RS02850	COG1696	Membrane protein involved in D-alanine export
AEI01_RS02855	COG1528	Iron-storage protein
AEI01_RS02860	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
AEI01_RS02865	COG0573	inorganic phosphate transmembrane transporter activity
AEI01_RS02870	COG0581	inorganic phosphate transmembrane transporter activity
AEI01_RS02880	COG0534	Mate efflux family protein
AEI01_RS02895	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
AEI01_RS02905	COG0298	carbon dioxide binding
AEI01_RS02910	COG0409	Hydrogenase expression formation protein
AEI01_RS02915	COG0309	Hydrogenase expression formation protein (HypE)
AEI01_RS02920	COG0375	protein maturation
AEI01_RS02935	COG0557	exoribonuclease II activity
AEI01_RS02950	COG0758	DNA mediated transformation
AEI01_RS02970	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
AEI01_RS02975	COG0563	adenylate kinase activity
AEI01_RS02990	COG0497	DNA recombination
AEI01_RS03000	COG0084	hydrolase, TatD family'
AEI01_RS03005	COG0791	NLP P60 protein
AEI01_RS03005	COG1388	LysM domain
AEI01_RS03010	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
AEI01_RS03030	COG0218	Necessary for normal cell division and for the maintenance of normal septation
AEI01_RS03080	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
AEI01_RS03095	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
AEI01_RS03100	COG0802	atpase or kinase
AEI01_RS03105	COG1137	ATPase activity
AEI01_RS03110	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
AEI01_RS03115	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
AEI01_RS03125	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
AEI01_RS03130	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
AEI01_RS03135	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
AEI01_RS03140	COG2205	protein histidine kinase activity
AEI01_RS03145	COG0556	nucleotide-excision repair
AEI01_RS03165	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
AEI01_RS03175	COG0529	Catalyzes the synthesis of activated sulfate
AEI01_RS03180	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
AEI01_RS03190	COG0280	phosphate acetyltransferase
AEI01_RS03215	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
AEI01_RS03220	COG0849	cell division
AEI01_RS03225	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
AEI01_RS03230	COG4786	Flagellar basal body rod
AEI01_RS03235	COG4786	Flagellar basal body rod
AEI01_RS03240	COG0174	glutamine synthetase
AEI01_RS03250	COG0826	peptidase U32
AEI01_RS03255	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
AEI01_RS03270	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
AEI01_RS03280	COG1519	Transferase
AEI01_RS03280	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AEI01_RS03285	COG0564	pseudouridine synthase activity
AEI01_RS03290	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
AEI01_RS03295	COG0228	four-way junction DNA binding
AEI01_RS03300	COG1837	Belongs to the UPF0109 family
AEI01_RS03305	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
AEI01_RS03310	COG0336	Belongs to the RNA methyltransferase TrmD family
AEI01_RS03315	COG0335	large ribosomal subunit rRNA binding
AEI01_RS03325	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
AEI01_RS03330	COG1393	Belongs to the ArsC family
AEI01_RS03340	COG0587	DNA-directed DNA polymerase activity
AEI01_RS03345	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
AEI01_RS03360	COG2890	protein-(glutamine-N5) methyltransferase activity
AEI01_RS03365	COG0501	Belongs to the peptidase M48B family
AEI01_RS03375	COG0521	Mo-molybdopterin cofactor biosynthetic process
AEI01_RS03380	COG0598	Magnesium transport protein CorA
AEI01_RS03410	COG3842	ATPase activity
AEI01_RS03460	COG1420	regulation of RNA biosynthetic process
AEI01_RS03490	COG0436	Aminotransferase
AEI01_RS03495	COG1045	serine acetyltransferase
AEI01_RS03500	COG1166	arginine decarboxylase activity
AEI01_RS03515	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
AEI01_RS03520	COG0163	prenyltransferase activity
AEI01_RS03530	COG1464	Belongs to the NlpA lipoprotein family
AEI01_RS03535	COG1464	Belongs to the NlpA lipoprotein family
AEI01_RS03540	COG1464	Belongs to the NlpA lipoprotein family
AEI01_RS03545	COG2011	ABC-type metal ion transport system permease component
AEI01_RS03550	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AEI01_RS03565	COG0210	DNA helicase
AEI01_RS03575	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
AEI01_RS03585	COG0437	4 iron, 4 sulfur cluster binding
AEI01_RS03590	COG0348	domain, Protein
AEI01_RS03595	COG3043	anaerobic respiration
AEI01_RS03630	COG0788	formyltetrahydrofolate deformylase activity
AEI01_RS03635	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
AEI01_RS03645	COG0642	Histidine kinase
AEI01_RS03655	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
AEI01_RS03675	COG0632	four-way junction helicase activity
AEI01_RS03685	COG0728	peptidoglycan biosynthetic process
AEI01_RS03695	COG1132	(ABC) transporter
AEI01_RS03700	COG0167	dihydroorotate dehydrogenase activity
AEI01_RS03705	COG0612	Peptidase, M16
AEI01_RS03715	COG1028	Short-chain dehydrogenase reductase Sdr
AEI01_RS03740	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
AEI01_RS03745	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
AEI01_RS03760	COG1338	Plays a role in the flagellum-specific transport system
AEI01_RS03795	COG0101	tRNA pseudouridine synthase activity
AEI01_RS03800	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
AEI01_RS03820	COG1757	Na H antiporter
AEI01_RS03825	COG4221	oxidoreductase activity
AEI01_RS03835	COG1049	propionate catabolic process, 2-methylcitrate cycle
AEI01_RS03840	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
AEI01_RS03850	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AEI01_RS03850	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AEI01_RS03890	COG1408	metallophosphoesterase
AEI01_RS03895	COG0688	phosphatidylethanolamine metabolic process
AEI01_RS03935	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
AEI01_RS03940	COG0681	Belongs to the peptidase S26 family
AEI01_RS03945	COG0303	'Molybdopterin
AEI01_RS03965	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
AEI01_RS03965	COG0512	Glutamine amidotransferase of anthranilate synthase
AEI01_RS03970	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
AEI01_RS03975	COG0582	viral genome integration into host DNA
AEI01_RS03980	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
AEI01_RS03985	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
AEI01_RS04000	COG3258	Cytochrome c
AEI01_RS04020	COG2404	hydrolase activity, acting on ester bonds
AEI01_RS04025	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
AEI01_RS04030	COG1959	2 iron, 2 sulfur cluster binding
AEI01_RS04035	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
AEI01_RS04040	COG1674	ftsk spoiiie
AEI01_RS04040	COG1196	nuclear chromosome segregation
AEI01_RS04045	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
AEI01_RS04060	COG0488	(ABC) transporter
AEI01_RS04065	COG5002	protein histidine kinase activity
AEI01_RS04070	COG0745	RESPONSE REGULATOR receiver
AEI01_RS04075	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
AEI01_RS04085	COG1185	polyribonucleotide nucleotidyltransferase activity
AEI01_RS04085	COG0539	negative regulation of cytoplasmic translation
AEI01_RS04100	COG0072	phenylalanine-tRNA ligase activity
AEI01_RS04100	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
AEI01_RS04105	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
AEI01_RS04110	COG0537	adenosine 5'-monophosphoramidase activity
AEI01_RS04125	COG0765	amino acid transport
AEI01_RS04135	COG1115	amino acid carrier protein
AEI01_RS04140	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
AEI01_RS04170	COG1999	signal sequence binding
AEI01_RS04175	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
AEI01_RS04180	COG0776	regulation of translation
AEI01_RS04200	COG1966	Carbon starvation protein
AEI01_RS04205	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
AEI01_RS04210	COG0765	amino acid transport
AEI01_RS04215	COG0765	amino acid transport
AEI01_RS04220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AEI01_RS04225	COG1126	abc transporter atp-binding protein
AEI01_RS04230	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
AEI01_RS04235	COG2201	protein-glutamate methylesterase activity
AEI01_RS04260	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
AEI01_RS04265	COG0012	GTP binding
AEI01_RS04280	COG0511	ligase activity, forming carbon-carbon bonds
AEI01_RS04280	COG5016	pyruvate
AEI01_RS04285	COG0733	neurotransmitter:sodium symporter activity
AEI01_RS04290	COG0733	neurotransmitter:sodium symporter activity
AEI01_RS04385	COG0765	amino acid transport
AEI01_RS04400	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
AEI01_RS04410	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
AEI01_RS04425	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
AEI01_RS04440	COG3290	protein histidine kinase activity
AEI01_RS04440	COG0840	transmembrane signaling receptor activity
AEI01_RS04450	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
AEI01_RS04470	COG0706	membrane insertase activity
AEI01_RS04475	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
AEI01_RS04485	COG0230	Belongs to the bacterial ribosomal protein bL34 family
AEI01_RS04500	COG0824	Thioesterase
AEI01_RS04545	COG2195	Cleaves the N-terminal amino acid of tripeptides
AEI01_RS04555	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
AEI01_RS04565	COG3022	response to hydroperoxide
AEI01_RS04570	COG1473	amidohydrolase
AEI01_RS04575	COG2807	transmembrane transport
AEI01_RS04595	COG2181	nitrate reductase activity
AEI01_RS04595	COG0247	lactate metabolic process
AEI01_RS04600	COG0635	Involved in the biosynthesis of porphyrin-containing compound
AEI01_RS04615	COG0113	porphobilinogen synthase activity
AEI01_RS04620	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
AEI01_RS04635	COG2855	membrane
AEI01_RS04640	COG0583	DNA-binding transcription factor activity
AEI01_RS04645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
AEI01_RS04665	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AEI01_RS04670	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
AEI01_RS04710	COG1333	cytochrome c biogenesis protein
AEI01_RS04710	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
AEI01_RS04735	COG0683	leucine binding
AEI01_RS04760	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
AEI01_RS04765	COG2204	response regulator
AEI01_RS04780	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
AEI01_RS04795	COG0481	GTPase activity
AEI01_RS04830	COG0439	Biotin carboxylase
AEI01_RS04835	COG0772	Belongs to the SEDS family
AEI01_RS04860	COG0352	thiamine-phosphate diphosphorylase activity
AEI01_RS04865	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
AEI01_RS04915	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
AEI01_RS04930	COG1193	negative regulation of DNA recombination
AEI01_RS04955	COG0516	GMP reductase activity
AEI01_RS04955	COG0517	IMP dehydrogenase activity
AEI01_RS04970	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
AEI01_RS04975	COG1058	Belongs to the CinA family
AEI01_RS04975	COG1546	Belongs to the CinA family
AEI01_RS04980	COG0456	acetyltransferase
AEI01_RS04985	COG0778	Nitroreductase
AEI01_RS04990	COG0778	Nitroreductase
AEI01_RS05000	COG0750	zinc metalloprotease
AEI01_RS05005	COG2990	Protein conserved in bacteria
AEI01_RS05015	COG2271	Major facilitator Superfamily
AEI01_RS05020	COG0360	Binds together with S18 to 16S ribosomal RNA
AEI01_RS05025	COG0629	single-stranded DNA binding
AEI01_RS05030	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
AEI01_RS05035	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
AEI01_RS05045	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
AEI01_RS05050	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
AEI01_RS05075	COG0352	thiamine-phosphate diphosphorylase activity
AEI01_RS05095	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
AEI01_RS05105	COG0739	heme binding
AEI01_RS05110	COG0285	dihydrofolate synthase activity
AEI01_RS05130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AEI01_RS05135	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
AEI01_RS05140	COG1862	Preprotein translocase
AEI01_RS05145	COG0815	Transfers the fatty acyl group on membrane lipoproteins
AEI01_RS05150	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
AEI01_RS05175	COG0210	DNA helicase
AEI01_RS05195	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
AEI01_RS05205	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
AEI01_RS05210	COG0542	response to heat
AEI01_RS05215	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
AEI01_RS05225	COG2095	MarC family integral membrane protein
AEI01_RS05230	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
AEI01_RS05235	COG2833	Protein of unknown function (DUF455)
AEI01_RS05240	COG1183	phosphatidylcholine synthase activity
AEI01_RS05250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
AEI01_RS05260	COG0745	RESPONSE REGULATOR receiver
AEI01_RS05270	COG1086	Polysaccharide biosynthesis protein
AEI01_RS05275	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AEI01_RS05280	COG0110	maltose O-acetyltransferase activity
AEI01_RS05285	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
AEI01_RS05290	COG0438	transferase activity, transferring glycosyl groups
AEI01_RS05295	COG1287	oligosaccharyl transferase activity
AEI01_RS05300	COG0438	transferase activity, transferring glycosyl groups
AEI01_RS05305	COG1215	transferase activity, transferring glycosyl groups
AEI01_RS05310	COG0438	transferase activity, transferring glycosyl groups
AEI01_RS05315	COG1132	(ABC) transporter
AEI01_RS05320	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AEI01_RS05330	COG0859	PFAM glycosyl transferase family 9
AEI01_RS05335	COG1560	Kdo2-lipid A biosynthetic process
AEI01_RS05340	COG0463	Glycosyl transferase, family 2
AEI01_RS05345	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
AEI01_RS05370	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AEI01_RS05380	COG1215	transferase activity, transferring glycosyl groups
AEI01_RS05415	COG1216	Glycosyl transferase, family 2
AEI01_RS05425	COG1696	Membrane protein involved in D-alanine export
AEI01_RS05445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
AEI01_RS05450	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
AEI01_RS05465	COG2217	Heavy metal translocating P-type atpase
AEI01_RS05470	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
AEI01_RS05475	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
AEI01_RS05485	COG2217	Heavy metal translocating P-type atpase
AEI01_RS05505	COG3610	response to peptide
AEI01_RS05515	COG0039	L-malate dehydrogenase activity
AEI01_RS05520	COG0586	Pfam SNARE associated Golgi protein
AEI01_RS05535	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
AEI01_RS05565	COG0194	GDP metabolic process
AEI01_RS05575	COG1684	flagellar biosynthetic protein fliR
AEI01_RS05590	COG0052	Belongs to the universal ribosomal protein uS2 family
AEI01_RS05595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
AEI01_RS05605	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
AEI01_RS05610	COG0723	plastoquinol--plastocyanin reductase activity
AEI01_RS05615	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
AEI01_RS05620	COG0445	tRNA wobble uridine modification
AEI01_RS05640	COG1301	dicarboxylic acid transport
AEI01_RS05655	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
AEI01_RS05690	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
AEI01_RS05705	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
AEI01_RS05710	COG0552	protein localization to endoplasmic reticulum
AEI01_RS05745	COG1295	ribonuclease BN
AEI01_RS05750	COG0277	FAD linked oxidase domain protein
AEI01_RS05760	COG0739	heme binding
AEI01_RS05770	COG1496	oxidoreductase activity
AEI01_RS05785	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
AEI01_RS05795	COG0642	Histidine kinase
AEI01_RS05800	COG0745	RESPONSE REGULATOR receiver
AEI01_RS05805	COG2703	oxygen carrier activity
AEI01_RS05820	COG0642	Histidine kinase
AEI01_RS05825	COG0745	RESPONSE REGULATOR receiver
AEI01_RS05830	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
AEI01_RS05835	COG0484	heat shock protein binding
AEI01_RS05840	COG0789	Transcriptional regulator
AEI01_RS05845	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
AEI01_RS05845	COG0475	glutathione-regulated potassium exporter activity
AEI01_RS05855	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
AEI01_RS05860	COG0751	glycine-tRNA ligase activity
AEI01_RS05865	COG0739	heme binding
AEI01_RS05875	COG0248	Ppx GppA phosphatase
AEI01_RS05895	COG2814	Major facilitator Superfamily
AEI01_RS05910	COG0731	radical SAM domain protein
AEI01_RS05965	COG1942	4-Oxalocrotonate Tautomerase
AEI01_RS05980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
AEI01_RS05985	COG4773	Receptor
AEI01_RS05995	COG0745	RESPONSE REGULATOR receiver
AEI01_RS06000	COG0642	Histidine kinase
AEI01_RS06010	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
AEI01_RS06015	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
AEI01_RS06020	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
AEI01_RS06025	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AEI01_RS06045	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
AEI01_RS06050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
AEI01_RS06055	COG1758	RNA polymerase activity
AEI01_RS06060	COG0528	UMP kinase activity
AEI01_RS06075	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
AEI01_RS06080	COG0220	tRNA (guanine-N7-)-methyltransferase activity
AEI01_RS06090	COG0564	pseudouridine synthase activity
AEI01_RS06095	COG0772	Belongs to the SEDS family
AEI01_RS06110	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
AEI01_RS06115	COG0569	domain protein
AEI01_RS06120	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AEI01_RS06125	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
AEI01_RS06130	COG0280	phosphate acetyltransferase
AEI01_RS06130	COG0281	malic enzyme
AEI01_RS06135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
AEI01_RS06145	COG0439	Biotin carboxylase
AEI01_RS06150	COG0511	ligase activity, forming carbon-carbon bonds
AEI01_RS06160	COG1086	Polysaccharide biosynthesis protein
AEI01_RS06165	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
AEI01_RS06185	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
AEI01_RS06200	COG1083	cytidylyl-transferase
AEI01_RS06205	COG3980	spore coat polysaccharide biosynthesis protein
AEI01_RS06210	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AEI01_RS06215	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
AEI01_RS06220	COG0107	imidazoleglycerol-phosphate synthase activity
AEI01_RS06235	COG2089	acid synthase
AEI01_RS06280	COG2165	general secretion pathway protein
AEI01_RS06300	COG0575	Belongs to the CDS family
AEI01_RS06310	COG1293	RNA-binding protein homologous to eukaryotic snRNP
AEI01_RS06320	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
AEI01_RS06325	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AEI01_RS06330	COG4605	iron ion homeostasis
AEI01_RS06335	COG4604	ABC transporter, ATP-binding protein
AEI01_RS06340	COG4607	ABC-type enterochelin transport system periplasmic component
AEI01_RS06365	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
AEI01_RS06370	COG3005	denitrification pathway
AEI01_RS06375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
AEI01_RS06400	COG0628	permease
AEI01_RS06405	COG0114	fumarate hydratase activity
AEI01_RS06410	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
AEI01_RS06420	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
AEI01_RS06425	COG2252	PERMEase
AEI01_RS06435	COG2853	Lipoprotein
AEI01_RS06455	COG2814	Major facilitator Superfamily
AEI01_RS06470	COG3276	selenocysteine insertion sequence binding
AEI01_RS06485	COG0716	FMN binding
AEI01_RS06500	COG0753	catalase activity
AEI01_RS06510	COG2964	Protein conserved in bacteria
AEI01_RS06515	COG0251	oxidation-reduction process
AEI01_RS06520	COG3069	C4-dicarboxylate transmembrane transporter activity
AEI01_RS06540	COG1918	ferrous iron import across plasma membrane
AEI01_RS06545	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
AEI01_RS06550	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
AEI01_RS06555	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
AEI01_RS06570	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
AEI01_RS06595	COG1580	Controls the rotational direction of flagella during chemotaxis
AEI01_RS06610	COG2124	cytochrome p450
AEI01_RS06630	COG1454	alcohol dehydrogenase
AEI01_RS06645	COG0529	Catalyzes the synthesis of activated sulfate
AEI01_RS06675	COG2089	acid synthase
AEI01_RS06690	COG1442	glycosyl transferase family 8
AEI01_RS06700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
AEI01_RS06705	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
AEI01_RS06715	COG1216	Glycosyl transferase, family 2
AEI01_RS06715	COG1442	glycosyl transferase family 8
AEI01_RS06720	COG1216	Glycosyl transferase, family 2
AEI01_RS06730	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
AEI01_RS06730	COG0517	IMP dehydrogenase activity
AEI01_RS06775	COG0037	tRNA processing
AEI01_RS06800	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
AEI01_RS06825	COG3951	Flagellar rod assembly protein muramidase FlgJ
AEI01_RS06850	COG0730	response to heat
AEI01_RS06855	COG1459	type II secretion system
AEI01_RS06860	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
AEI01_RS06890	COG0546	phosphoglycolate phosphatase activity
AEI01_RS06900	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
AEI01_RS06905	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
AEI01_RS06910	COG0210	DNA helicase
AEI01_RS06915	COG2887	Belongs to the helicase family. UvrD subfamily
AEI01_RS06960	COG0745	RESPONSE REGULATOR receiver
AEI01_RS06975	COG0505	Belongs to the CarA family
AEI01_RS07010	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
AEI01_RS07040	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
AEI01_RS07050	COG0437	4 iron, 4 sulfur cluster binding
AEI01_RS07085	COG0314	molybdopterin synthase activity
AEI01_RS07090	COG0303	'Molybdopterin
AEI01_RS07095	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
AEI01_RS07105	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
AEI01_RS07110	COG3069	C4-dicarboxylate transmembrane transporter activity
AEI01_RS07120	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
AEI01_RS07125	COG0237	dephospho-CoA kinase activity
AEI01_RS07135	COG2992	FlgJ-related protein
AEI01_RS07145	COG0783	Belongs to the Dps family
AEI01_RS07150	COG0166	Belongs to the GPI family
AEI01_RS07165	COG3839	Belongs to the ABC transporter superfamily
AEI01_RS07170	COG4662	Binding-protein-dependent transport system inner membrane component
AEI01_RS07175	COG2998	abc-type tungstate transport system, permease component
AEI01_RS07185	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
AEI01_RS07190	COG1984	allophanate hydrolase subunit 2
AEI01_RS07200	COG2249	NAD(P)H dehydrogenase (quinone) activity
AEI01_RS07205	COG1733	regulation of RNA biosynthetic process
AEI01_RS07215	COG1064	alcohol dehydrogenase
AEI01_RS07235	COG0732	type I restriction modification DNA specificity domain
AEI01_RS07255	COG2814	Major facilitator Superfamily
AEI01_RS07260	COG0701	Predicted permease
AEI01_RS07265	COG0640	Transcriptional regulator
AEI01_RS07275	COG0798	PFAM Bile acid sodium symporter
AEI01_RS07425	COG4397	Mu-like prophage major head subunit gpT
AEI01_RS07470	COG4383	Mu-like prophage protein gp29
AEI01_RS07565	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
AEI01_RS07580	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AEI01_RS07585	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
AEI01_RS07595	COG0839	Belongs to the complex I subunit 6 family
AEI01_RS07630	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AEI01_RS07640	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
AEI01_RS07655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
AEI01_RS07660	COG0601	transmembrane transport
AEI01_RS07675	COG0437	4 iron, 4 sulfur cluster binding
AEI01_RS07695	COG4615	Cyclic peptide transporter
AEI01_RS07705	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
AEI01_RS07710	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
AEI01_RS07715	COG0257	Belongs to the bacterial ribosomal protein bL36 family
AEI01_RS07725	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
AEI01_RS07730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
AEI01_RS07735	COG0202	RNA polymerase activity
AEI01_RS07740	COG0203	ribosomal protein L17
AEI01_RS07775	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
AEI01_RS07775	COG0140	phosphoribosyl-ATP diphosphatase activity
AEI01_RS07780	COG2171	N-acyltransferase activity
AEI01_RS07785	COG0489	protein tyrosine kinase activity
AEI01_RS07795	COG0745	RESPONSE REGULATOR receiver
AEI01_RS07800	COG2046	Belongs to the sulfate adenylyltransferase family
AEI01_RS07805	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
AEI01_RS07810	COG0268	Binds directly to 16S ribosomal RNA
AEI01_RS07815	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
AEI01_RS07820	COG0748	coenzyme F420 binding
AEI01_RS07825	COG4771	TonB-dependent receptor
AEI01_RS07830	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
AEI01_RS07835	COG1120	ATPase activity
AEI01_RS07840	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
AEI01_RS07850	COG0477	Major facilitator Superfamily
AEI01_RS07855	COG1194	a g-specific adenine glycosylase
AEI01_RS07895	COG1760	l-serine dehydratase
AEI01_RS07900	COG0814	amino acid
AEI01_RS07915	COG0811	peptide transport
AEI01_RS07920	COG0848	biopolymer transport protein
AEI01_RS07955	COG0328	RNA-DNA hybrid ribonuclease activity
AEI01_RS07965	COG0358	DNA primase activity
AEI01_RS07980	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
AEI01_RS07985	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
AEI01_RS08000	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
AEI01_RS08005	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
AEI01_RS08010	COG1127	ABC transporter
AEI01_RS08020	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
AEI01_RS08020	COG3218	ABC-type transport auxiliary lipoprotein component
AEI01_RS08030	COG0024	Methionine aminopeptidase
AEI01_RS08035	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
AEI01_RS08040	COG0791	NLP P60 protein
AEI01_RS08050	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
AEI01_RS08065	COG0672	)-iron permease
AEI01_RS08090	COG1136	(ABC) transporter
AEI01_RS08140	COG1793	dna ligase
AEI01_RS08155	COG0148	phosphopyruvate hydratase activity
AEI01_RS08160	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
AEI01_RS08165	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
AEI01_RS08170	COG1987	bacterial-type flagellum assembly
AEI01_RS08185	COG1218	3'(2'),5'-bisphosphate nucleotidase
AEI01_RS08190	COG0372	Belongs to the citrate synthase family
AEI01_RS08205	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
AEI01_RS08215	COG3842	ATPase activity
AEI01_RS08220	COG1175	transmembrane transport
AEI01_RS08235	COG1653	transport
AEI01_RS08245	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
AEI01_RS08250	COG0201	protein transport
AEI01_RS08255	COG0200	Binds to the 23S rRNA
AEI01_RS08260	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
AEI01_RS08265	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
AEI01_RS08270	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
AEI01_RS08275	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
AEI01_RS08280	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
AEI01_RS08285	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
AEI01_RS08290	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
AEI01_RS08295	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
AEI01_RS08300	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
AEI01_RS08305	COG0255	Belongs to the universal ribosomal protein uL29 family
AEI01_RS08310	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
AEI01_RS08315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
AEI01_RS08325	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
AEI01_RS08335	COG0089	rRNA binding
AEI01_RS08345	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
AEI01_RS08350	COG0051	transcription antitermination factor activity, RNA binding
AEI01_RS08355	COG1187	pseudouridine synthase activity
AEI01_RS08360	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
AEI01_RS08425	COG0473	3-isopropylmalate dehydrogenase activity
AEI01_RS08445	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
AEI01_RS08450	COG1749	Flagellar hook protein flgE
AEI01_RS08455	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
AEI01_RS08465	COG0592	DNA-directed DNA polymerase activity
AEI01_RS08470	COG0187	DNA topoisomerase II activity
AEI01_RS08485	COG2056	Na+-H+ antiporter family
AEI01_RS08490	COG0069	glutamate synthase activity
AEI01_RS08490	COG0067	glutamate synthase
AEI01_RS08490	COG0070	glutamate synthase
AEI01_RS08495	COG0493	'glutamate synthase
AEI01_RS08510	COG1592	Rubrerythrin
AEI01_RS08520	COG3477	response to acidic pH
AEI01_RS08545	COG0840	transmembrane signaling receptor activity
AEI01_RS08550	COG1858	cytochrome C peroxidase
AEI01_RS08555	COG0179	Fumarylacetoacetate (FAA) hydrolase
AEI01_RS08560	COG0564	pseudouridine synthase activity
AEI01_RS08565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
AEI01_RS08570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
AEI01_RS08575	COG1823	symporter activity
AEI01_RS08595	COG0252	asparaginase activity
AEI01_RS08605	COG1442	glycosyl transferase family 8
AEI01_RS08610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella