locus-tag	class	description
RC12_RS00030	COG2814	Major facilitator Superfamily
RC12_RS00050	COG1217	gtp-binding protein TYPA
RC12_RS00065	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
RC12_RS00100	COG1611	Belongs to the LOG family
RC12_RS00105	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RC12_RS00105	COG1776	CheC inhibitor of MCP methylation
RC12_RS00110	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RC12_RS00115	COG1191	sigma factor activity
RC12_RS00125	COG0455	bacterial-type flagellum organization
RC12_RS00130	COG1419	protein localization to endoplasmic reticulum
RC12_RS00135	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RC12_RS00140	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RC12_RS00145	COG0402	S-adenosylhomocysteine deaminase activity
RC12_RS00150	COG0616	signal peptide processing
RC12_RS00175	COG1139	Iron-sulfur cluster binding protein
RC12_RS00180	COG0247	lactate metabolic process
RC12_RS00210	COG1271	oxidase subunit
RC12_RS00215	COG1294	oxidase, subunit
RC12_RS00235	COG1794	racemase activity, acting on amino acids and derivatives
RC12_RS00240	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RC12_RS00245	COG1027	Aspartate ammonia-lyase
RC12_RS00250	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RC12_RS00280	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RC12_RS00285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RC12_RS00300	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RC12_RS00305	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
RC12_RS00305	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
RC12_RS00310	COG1192	Involved in chromosome partitioning
RC12_RS00315	COG1475	DNA binding
RC12_RS00325	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RC12_RS00330	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RC12_RS00345	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RC12_RS00355	COG0811	peptide transport
RC12_RS00360	COG0848	biopolymer transport protein
RC12_RS00375	COG2885	chlorophyll binding
RC12_RS00385	COG1047	Peptidyl-prolyl cis-trans
RC12_RS00390	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RC12_RS00395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RC12_RS00400	COG0037	tRNA processing
RC12_RS00415	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RC12_RS00435	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RC12_RS00445	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RC12_RS00455	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RC12_RS00465	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RC12_RS00490	COG0083	homoserine kinase activity
RC12_RS00510	COG0779	Required for maturation of 30S ribosomal subunits
RC12_RS00525	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RC12_RS00530	COG1121	(ABC) transporter
RC12_RS00560	COG0492	ferredoxin-NADP+ reductase activity
RC12_RS00565	COG3118	belongs to the thioredoxin family
RC12_RS00575	COG0460	homoserine dehydrogenase
RC12_RS00580	COG0436	Aminotransferase
RC12_RS00595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RC12_RS00600	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RC12_RS00605	COG0254	rRNA binding
RC12_RS00610	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RC12_RS00630	COG0602	queuosine metabolic process
RC12_RS00635	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RC12_RS00660	COG1971	Probably functions as a manganese efflux pump
RC12_RS00675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RC12_RS00695	COG1840	ABC-type Fe3 transport system, periplasmic component
RC12_RS00705	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
RC12_RS00710	COG1253	flavin adenine dinucleotide binding
RC12_RS00720	COG2824	Alkylphosphonate utilization operon protein PhnA
RC12_RS00725	COG0861	Integral membrane protein TerC family
RC12_RS00730	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RC12_RS00735	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RC12_RS00735	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RC12_RS00745	COG0606	chelatase, subunit chli
RC12_RS00750	COG0242	peptide deformylase activity
RC12_RS00770	COG1157	protein secretion by the type III secretion system
RC12_RS00775	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RC12_RS00785	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RC12_RS00785	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RC12_RS00800	COG2851	Citrate transporter
RC12_RS00805	COG1297	OPT oligopeptide transporter protein
RC12_RS00820	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RC12_RS00855	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RC12_RS00860	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RC12_RS00865	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RC12_RS00880	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RC12_RS00900	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RC12_RS00905	COG0670	Belongs to the BI1 family
RC12_RS00910	COG0288	reversible hydration of carbon dioxide
RC12_RS00915	COG0668	transmembrane transport
RC12_RS00940	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RC12_RS00945	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RC12_RS00950	COG0840	transmembrane signaling receptor activity
RC12_RS00950	COG3290	protein histidine kinase activity
RC12_RS00985	COG2921	Belongs to the UPF0250 family
RC12_RS00995	COG0708	Exodeoxyribonuclease III
RC12_RS01000	COG2194	sulfuric ester hydrolase activity
RC12_RS01005	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RC12_RS01015	COG0418	dihydroorotase activity
RC12_RS01025	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RC12_RS01310	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RC12_RS01330	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RC12_RS01335	COG0802	atpase or kinase
RC12_RS01340	COG1137	ATPase activity
RC12_RS01345	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RC12_RS01350	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RC12_RS01355	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RC12_RS01360	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RC12_RS01365	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
RC12_RS01370	COG2205	protein histidine kinase activity
RC12_RS01375	COG0556	nucleotide-excision repair
RC12_RS01395	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RC12_RS01400	COG1213	nucleotidyl transferase
RC12_RS01415	COG2856	Zn peptidase
RC12_RS01435	COG0428	transporter
RC12_RS01465	COG0330	HflC and HflK could
RC12_RS01475	COG1942	4-Oxalocrotonate Tautomerase
RC12_RS01480	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RC12_RS01485	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RC12_RS01500	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RC12_RS01505	COG1077	Cell shape determining protein MreB Mrl
RC12_RS01515	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RC12_RS01535	COG0835	chemotaxis
RC12_RS01540	COG2198	Histidine kinase
RC12_RS01540	COG0784	Response regulator, receiver
RC12_RS01540	COG0643	Histidine kinase
RC12_RS01545	COG0784	Response regulator, receiver
RC12_RS01545	COG0835	chemotaxis
RC12_RS01555	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RC12_RS01560	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RC12_RS01610	COG4106	trans-aconitate 2-methyltransferase activity
RC12_RS01615	COG2830	Protein of unknown function (DUF452)
RC12_RS01625	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RC12_RS01630	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RC12_RS01635	COG2076	Multidrug Resistance protein
RC12_RS01650	COG0193	aminoacyl-tRNA hydrolase activity
RC12_RS01660	COG0019	diaminopimelate decarboxylase activity
RC12_RS01685	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RC12_RS01695	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RC12_RS01720	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RC12_RS01725	COG0251	oxidation-reduction process
RC12_RS01730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RC12_RS01740	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RC12_RS01760	COG0450	alkyl hydroperoxide reductase
RC12_RS01765	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RC12_RS01770	COG1360	Flagellar Motor Protein
RC12_RS01775	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RC12_RS01785	COG0477	Major facilitator Superfamily
RC12_RS01795	COG1238	metal cluster binding
RC12_RS01800	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RC12_RS01805	COG0730	response to heat
RC12_RS01820	COG0512	Glutamine amidotransferase of anthranilate synthase
RC12_RS01820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RC12_RS01830	COG0133	tryptophan synthase activity
RC12_RS01845	COG1776	CheC inhibitor of MCP methylation
RC12_RS01845	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RC12_RS01860	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RC12_RS01865	COG0745	RESPONSE REGULATOR receiver
RC12_RS01885	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RC12_RS01895	COG1981	membrane
RC12_RS01900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RC12_RS01910	COG1538	Outer membrane efflux protein
RC12_RS01920	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RC12_RS01935	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RC12_RS01945	COG0754	glutathionylspermidine amidase activity
RC12_RS01950	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RC12_RS01970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RC12_RS01975	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RC12_RS01980	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RC12_RS01985	COG0284	orotidine-5'-phosphate decarboxylase activity
RC12_RS01990	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RC12_RS01995	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RC12_RS02000	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RC12_RS02010	COG1160	GTP binding
RC12_RS02045	COG0579	oxidoreductase
RC12_RS02050	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RC12_RS02070	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RC12_RS02105	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RC12_RS02125	COG1053	succinate dehydrogenase
RC12_RS02130	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RC12_RS02205	COG0488	(ABC) transporter
RC12_RS02220	COG1739	Uncharacterized protein family UPF0029
RC12_RS02240	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RC12_RS02260	COG1028	Short-chain dehydrogenase reductase Sdr
RC12_RS02270	COG1053	succinate dehydrogenase
RC12_RS02275	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RC12_RS02280	COG2048	Heterodisulfide reductase, subunit B
RC12_RS02285	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RC12_RS02290	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RC12_RS02295	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RC12_RS02305	COG4771	TonB-dependent receptor
RC12_RS02310	COG0494	nUDIX hydrolase
RC12_RS02325	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RC12_RS02330	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RC12_RS02360	COG2121	Domain of unknown function (DUF374)
RC12_RS02375	COG0195	Participates in both transcription termination and antitermination
RC12_RS02385	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
RC12_RS02390	COG0612	Peptidase, M16
RC12_RS02395	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RC12_RS02400	COG2346	COG2346, Truncated hemoglobins
RC12_RS02415	COG0765	amino acid transport
RC12_RS02445	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RC12_RS02450	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RC12_RS02465	COG0250	Participates in transcription elongation, termination and antitermination
RC12_RS02470	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RC12_RS02475	COG0081	regulation of translation
RC12_RS02480	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RC12_RS02485	COG0222	ribosome binding
RC12_RS02500	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RC12_RS02505	COG0049	tRNA binding
RC12_RS02540	COG0134	indole-3-glycerol-phosphate synthase activity
RC12_RS02550	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
RC12_RS02555	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RC12_RS02560	COG0673	inositol 2-dehydrogenase activity
RC12_RS02570	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RC12_RS02575	COG0424	maF-like protein
RC12_RS02585	COG0542	response to heat
RC12_RS02590	COG1937	Protein conserved in bacteria
RC12_RS02595	COG0793	Belongs to the peptidase S41A family
RC12_RS02600	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RC12_RS02605	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RC12_RS02610	COG0047	phosphoribosylformylglycinamidine synthase activity
RC12_RS02620	COG0204	Acyl-transferase
RC12_RS02630	COG0326	Molecular chaperone. Has ATPase activity
RC12_RS02635	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RC12_RS02655	COG1677	Flagellar hook-basal body complex protein FliE
RC12_RS02660	COG1558	bacterial-type flagellum-dependent cell motility
RC12_RS02665	COG1815	bacterial-type flagellum-dependent cell motility
RC12_RS02685	COG0039	L-malate dehydrogenase activity
RC12_RS02695	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RC12_RS02705	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RC12_RS02705	COG0674	pyruvate-flavodoxin oxidoreductase activity
RC12_RS02710	COG1013	pyruvate-flavodoxin oxidoreductase activity
RC12_RS02730	COG0142	geranyltranstransferase activity
RC12_RS02750	COG0181	hydroxymethylbilane synthase activity
RC12_RS02755	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RC12_RS02765	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RC12_RS02785	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RC12_RS02815	COG1289	transmembrane transporter activity
RC12_RS02820	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RC12_RS02825	COG0492	ferredoxin-NADP+ reductase activity
RC12_RS02840	COG0305	Participates in initiation and elongation during chromosome replication
RC12_RS02860	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RC12_RS02860	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RC12_RS02865	COG1610	YqeY-like protein
RC12_RS02870	COG0028	Belongs to the TPP enzyme family
RC12_RS02875	COG0440	acetolactate synthase activity
RC12_RS02885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RC12_RS02890	COG0805	protein transport
RC12_RS02900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RC12_RS02905	COG0494	nUDIX hydrolase
RC12_RS02910	COG0527	aspartate kinase activity
RC12_RS02925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RC12_RS02945	COG0196	riboflavin kinase activity
RC12_RS02950	COG2890	protein-(glutamine-N5) methyltransferase activity
RC12_RS02965	COG2860	membrane
RC12_RS02975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RC12_RS02980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RC12_RS02985	COG0191	fructose-bisphosphate aldolase activity
RC12_RS03005	COG0733	neurotransmitter:sodium symporter activity
RC12_RS03025	COG1473	amidohydrolase
RC12_RS03030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RC12_RS03035	COG1136	(ABC) transporter
RC12_RS03035	COG0577	efflux transmembrane transporter activity
RC12_RS03040	COG1538	Outer membrane efflux protein
RC12_RS03055	COG1696	Membrane protein involved in D-alanine export
RC12_RS03060	COG1528	Iron-storage protein
RC12_RS03065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RC12_RS03070	COG0573	inorganic phosphate transmembrane transporter activity
RC12_RS03075	COG0581	inorganic phosphate transmembrane transporter activity
RC12_RS03085	COG0534	Mate efflux family protein
RC12_RS03100	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
RC12_RS03110	COG0298	carbon dioxide binding
RC12_RS03115	COG0409	Hydrogenase expression formation protein
RC12_RS03120	COG0309	Hydrogenase expression formation protein (HypE)
RC12_RS03125	COG0375	protein maturation
RC12_RS03135	COG0557	exoribonuclease II activity
RC12_RS03140	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RC12_RS03150	COG0758	DNA mediated transformation
RC12_RS03165	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RC12_RS03170	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RC12_RS03175	COG0563	adenylate kinase activity
RC12_RS03180	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RC12_RS03190	COG0497	DNA recombination
RC12_RS03200	COG0084	hydrolase, TatD family'
RC12_RS03205	COG0791	NLP P60 protein
RC12_RS03205	COG1388	LysM domain
RC12_RS03210	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RC12_RS03265	COG0529	Catalyzes the synthesis of activated sulfate
RC12_RS03270	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RC12_RS03280	COG0280	phosphate acetyltransferase
RC12_RS03305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RC12_RS03310	COG0849	cell division
RC12_RS03315	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RC12_RS03320	COG4786	Flagellar basal body rod
RC12_RS03325	COG4786	Flagellar basal body rod
RC12_RS03330	COG0174	glutamine synthetase
RC12_RS03340	COG0826	peptidase U32
RC12_RS03345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RC12_RS03355	COG0752	glycyl-tRNA synthetase alpha subunit
RC12_RS03360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RC12_RS03370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RC12_RS03370	COG1519	Transferase
RC12_RS03375	COG0564	pseudouridine synthase activity
RC12_RS03380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RC12_RS03385	COG0228	four-way junction DNA binding
RC12_RS03390	COG1837	Belongs to the UPF0109 family
RC12_RS03395	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RC12_RS03400	COG0336	Belongs to the RNA methyltransferase TrmD family
RC12_RS03405	COG0335	large ribosomal subunit rRNA binding
RC12_RS03415	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
RC12_RS03420	COG1393	Belongs to the ArsC family
RC12_RS03425	COG0587	DNA-directed DNA polymerase activity
RC12_RS03430	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RC12_RS03445	COG2890	protein-(glutamine-N5) methyltransferase activity
RC12_RS03460	COG0521	Mo-molybdopterin cofactor biosynthetic process
RC12_RS03465	COG0598	Magnesium transport protein CorA
RC12_RS03485	COG1178	ABC-type Fe3 transport system permease component
RC12_RS03535	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RC12_RS03550	COG1181	Belongs to the D-alanine--D-alanine ligase family
RC12_RS03555	COG0632	four-way junction helicase activity
RC12_RS03565	COG0728	peptidoglycan biosynthetic process
RC12_RS03575	COG1132	(ABC) transporter
RC12_RS03580	COG0167	dihydroorotate dehydrogenase activity
RC12_RS03585	COG0612	Peptidase, M16
RC12_RS03595	COG1028	Short-chain dehydrogenase reductase Sdr
RC12_RS03610	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RC12_RS03620	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RC12_RS03625	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RC12_RS03635	COG1420	regulation of RNA biosynthetic process
RC12_RS03685	COG0436	Aminotransferase
RC12_RS03690	COG1045	serine acetyltransferase
RC12_RS03695	COG1166	arginine decarboxylase activity
RC12_RS03710	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RC12_RS03715	COG0163	prenyltransferase activity
RC12_RS03725	COG1464	Belongs to the NlpA lipoprotein family
RC12_RS03730	COG1464	Belongs to the NlpA lipoprotein family
RC12_RS03735	COG1464	Belongs to the NlpA lipoprotein family
RC12_RS03740	COG2011	ABC-type metal ion transport system permease component
RC12_RS03745	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RC12_RS03760	COG0210	DNA helicase
RC12_RS03770	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
RC12_RS03780	COG0437	4 iron, 4 sulfur cluster binding
RC12_RS03785	COG0348	domain, Protein
RC12_RS03790	COG3043	anaerobic respiration
RC12_RS03825	COG0788	formyltetrahydrofolate deformylase activity
RC12_RS03830	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RC12_RS03840	COG0642	Histidine kinase
RC12_RS03855	COG1338	Plays a role in the flagellum-specific transport system
RC12_RS03890	COG0101	tRNA pseudouridine synthase activity
RC12_RS03895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RC12_RS03915	COG1757	Na H antiporter
RC12_RS03920	COG4221	oxidoreductase activity
RC12_RS03930	COG1049	propionate catabolic process, 2-methylcitrate cycle
RC12_RS03935	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RC12_RS03945	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RC12_RS03945	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RC12_RS03955	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RC12_RS03980	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RC12_RS03985	COG1408	metallophosphoesterase
RC12_RS03990	COG0688	phosphatidylethanolamine metabolic process
RC12_RS04030	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RC12_RS04035	COG0681	Belongs to the peptidase S26 family
RC12_RS04040	COG0303	'Molybdopterin
RC12_RS04060	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RC12_RS04060	COG0512	Glutamine amidotransferase of anthranilate synthase
RC12_RS04065	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RC12_RS04070	COG0582	viral genome integration into host DNA
RC12_RS04080	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RC12_RS04095	COG3258	Cytochrome c
RC12_RS04120	COG2404	hydrolase activity, acting on ester bonds
RC12_RS04125	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RC12_RS04130	COG1959	2 iron, 2 sulfur cluster binding
RC12_RS04135	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RC12_RS04140	COG1196	nuclear chromosome segregation
RC12_RS04140	COG1674	ftsk spoiiie
RC12_RS04145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RC12_RS04160	COG0488	(ABC) transporter
RC12_RS04165	COG5002	protein histidine kinase activity
RC12_RS04170	COG0745	RESPONSE REGULATOR receiver
RC12_RS04175	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RC12_RS04185	COG0539	negative regulation of cytoplasmic translation
RC12_RS04185	COG1185	polyribonucleotide nucleotidyltransferase activity
RC12_RS04200	COG0072	phenylalanine-tRNA ligase activity
RC12_RS04200	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RC12_RS04205	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RC12_RS04210	COG0537	adenosine 5'-monophosphoramidase activity
RC12_RS04225	COG0765	amino acid transport
RC12_RS04235	COG1115	amino acid carrier protein
RC12_RS04240	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RC12_RS04275	COG1999	signal sequence binding
RC12_RS04280	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RC12_RS04285	COG0776	regulation of translation
RC12_RS04305	COG1966	Carbon starvation protein
RC12_RS04310	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RC12_RS04315	COG0765	amino acid transport
RC12_RS04320	COG0765	amino acid transport
RC12_RS04325	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RC12_RS04330	COG1126	abc transporter atp-binding protein
RC12_RS04335	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RC12_RS04340	COG2201	protein-glutamate methylesterase activity
RC12_RS04365	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RC12_RS04370	COG0012	GTP binding
RC12_RS04385	COG0511	ligase activity, forming carbon-carbon bonds
RC12_RS04385	COG5016	pyruvate
RC12_RS04390	COG0733	neurotransmitter:sodium symporter activity
RC12_RS04395	COG0733	neurotransmitter:sodium symporter activity
RC12_RS04445	COG0318	PFAM AMP-dependent synthetase and ligase
RC12_RS04445	COG0204	Acyl-transferase
RC12_RS04490	COG0765	amino acid transport
RC12_RS04500	COG0653	protein targeting
RC12_RS04505	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RC12_RS04515	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RC12_RS04530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RC12_RS04545	COG0840	transmembrane signaling receptor activity
RC12_RS04550	COG0138	bifunctional purine biosynthesis protein purh
RC12_RS04555	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RC12_RS04575	COG0706	membrane insertase activity
RC12_RS04580	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RC12_RS04590	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RC12_RS04610	COG0824	Thioesterase
RC12_RS04640	COG2703	oxygen carrier activity
RC12_RS04645	COG0500	methyltransferase
RC12_RS04665	COG2195	Cleaves the N-terminal amino acid of tripeptides
RC12_RS04670	COG0477	Major facilitator Superfamily
RC12_RS04675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RC12_RS04685	COG3022	response to hydroperoxide
RC12_RS04690	COG1473	amidohydrolase
RC12_RS04705	COG2807	transmembrane transport
RC12_RS04725	COG0247	lactate metabolic process
RC12_RS04725	COG2181	nitrate reductase activity
RC12_RS04730	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RC12_RS04740	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RC12_RS04745	COG0113	porphobilinogen synthase activity
RC12_RS04750	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RC12_RS04755	COG0357	Ribosomal RNA small subunit methyltransferase G
RC12_RS04765	COG2855	membrane
RC12_RS04770	COG0583	DNA-binding transcription factor activity
RC12_RS04775	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RC12_RS04795	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RC12_RS04800	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RC12_RS04810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RC12_RS04820	COG0343	queuine tRNA-ribosyltransferase activity
RC12_RS04840	COG1333	cytochrome c biogenesis protein
RC12_RS04840	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RC12_RS04890	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RC12_RS04895	COG2204	response regulator
RC12_RS04910	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RC12_RS04925	COG0481	GTPase activity
RC12_RS04950	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RC12_RS04960	COG0439	Biotin carboxylase
RC12_RS04965	COG0772	Belongs to the SEDS family
RC12_RS04970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RC12_RS04990	COG0352	thiamine-phosphate diphosphorylase activity
RC12_RS04995	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RC12_RS05000	COG2022	thiamine diphosphate biosynthetic process
RC12_RS05020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RC12_RS05035	COG1193	negative regulation of DNA recombination
RC12_RS05060	COG0516	GMP reductase activity
RC12_RS05060	COG0517	IMP dehydrogenase activity
RC12_RS05065	COG0154	amidase activity
RC12_RS05075	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RC12_RS05080	COG1058	Belongs to the CinA family
RC12_RS05080	COG1546	Belongs to the CinA family
RC12_RS05090	COG0778	Nitroreductase
RC12_RS05095	COG0778	Nitroreductase
RC12_RS05105	COG0750	zinc metalloprotease
RC12_RS05110	COG2990	Protein conserved in bacteria
RC12_RS05115	COG0360	Binds together with S18 to 16S ribosomal RNA
RC12_RS05120	COG0629	single-stranded DNA binding
RC12_RS05125	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RC12_RS05130	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RC12_RS05140	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
RC12_RS05145	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RC12_RS05170	COG0352	thiamine-phosphate diphosphorylase activity
RC12_RS05190	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RC12_RS05200	COG0739	heme binding
RC12_RS05205	COG0285	dihydrofolate synthase activity
RC12_RS05225	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RC12_RS05230	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RC12_RS05235	COG1862	Preprotein translocase
RC12_RS05240	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RC12_RS05245	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RC12_RS05270	COG0210	DNA helicase
RC12_RS05290	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RC12_RS05300	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RC12_RS05305	COG0542	response to heat
RC12_RS05310	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RC12_RS05320	COG2095	MarC family integral membrane protein
RC12_RS05325	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RC12_RS05330	COG2833	Protein of unknown function (DUF455)
RC12_RS05335	COG1183	phosphatidylcholine synthase activity
RC12_RS05345	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RC12_RS05355	COG0745	RESPONSE REGULATOR receiver
RC12_RS05365	COG1086	Polysaccharide biosynthesis protein
RC12_RS05370	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RC12_RS05375	COG0110	maltose O-acetyltransferase activity
RC12_RS05380	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RC12_RS05385	COG0438	transferase activity, transferring glycosyl groups
RC12_RS05390	COG1287	oligosaccharyl transferase activity
RC12_RS05395	COG0438	transferase activity, transferring glycosyl groups
RC12_RS05400	COG1215	transferase activity, transferring glycosyl groups
RC12_RS05405	COG0438	transferase activity, transferring glycosyl groups
RC12_RS05410	COG1132	(ABC) transporter
RC12_RS05415	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RC12_RS05425	COG0859	PFAM glycosyl transferase family 9
RC12_RS05430	COG1560	Kdo2-lipid A biosynthetic process
RC12_RS05435	COG0463	Glycosyl transferase, family 2
RC12_RS05440	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RC12_RS05465	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RC12_RS05505	COG1216	Glycosyl transferase, family 2
RC12_RS05515	COG1696	Membrane protein involved in D-alanine export
RC12_RS05530	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RC12_RS05530	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RC12_RS05540	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RC12_RS05555	COG2217	Heavy metal translocating P-type atpase
RC12_RS05560	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RC12_RS05565	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RC12_RS05575	COG2217	Heavy metal translocating P-type atpase
RC12_RS05595	COG3610	response to peptide
RC12_RS05605	COG0586	Pfam SNARE associated Golgi protein
RC12_RS05620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RC12_RS05640	COG0018	arginyl-trna synthetase
RC12_RS05645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RC12_RS05650	COG0194	GDP metabolic process
RC12_RS05660	COG1684	flagellar biosynthetic protein fliR
RC12_RS05665	COG1136	(ABC) transporter
RC12_RS05670	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RC12_RS05675	COG0052	Belongs to the universal ribosomal protein uS2 family
RC12_RS05680	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RC12_RS05690	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RC12_RS05695	COG0723	plastoquinol--plastocyanin reductase activity
RC12_RS05700	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RC12_RS05725	COG1301	dicarboxylic acid transport
RC12_RS05740	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RC12_RS05745	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RC12_RS05755	COG1854	S-ribosylhomocysteine lyase activity
RC12_RS05765	COG1464	Belongs to the NlpA lipoprotein family
RC12_RS05775	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RC12_RS05790	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RC12_RS05795	COG0552	protein localization to endoplasmic reticulum
RC12_RS05825	COG1295	ribonuclease BN
RC12_RS05830	COG0277	FAD linked oxidase domain protein
RC12_RS05840	COG0739	heme binding
RC12_RS05850	COG1496	oxidoreductase activity
RC12_RS05865	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RC12_RS05875	COG0642	Histidine kinase
RC12_RS05880	COG0745	RESPONSE REGULATOR receiver
RC12_RS05885	COG2703	oxygen carrier activity
RC12_RS05900	COG0642	Histidine kinase
RC12_RS05905	COG0745	RESPONSE REGULATOR receiver
RC12_RS05915	COG0484	heat shock protein binding
RC12_RS05920	COG0789	Transcriptional regulator
RC12_RS05925	COG0475	glutathione-regulated potassium exporter activity
RC12_RS05925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RC12_RS05935	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RC12_RS05940	COG0751	glycine-tRNA ligase activity
RC12_RS05945	COG0739	heme binding
RC12_RS05955	COG0248	Ppx GppA phosphatase
RC12_RS05965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RC12_RS05975	COG2814	Major facilitator Superfamily
RC12_RS05990	COG0731	radical SAM domain protein
RC12_RS06060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RC12_RS06065	COG4773	Receptor
RC12_RS06075	COG0745	RESPONSE REGULATOR receiver
RC12_RS06080	COG0642	Histidine kinase
RC12_RS06085	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RC12_RS06090	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RC12_RS06095	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
RC12_RS06100	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
RC12_RS06105	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
RC12_RS06125	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RC12_RS06130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RC12_RS06135	COG1758	RNA polymerase activity
RC12_RS06140	COG0528	UMP kinase activity
RC12_RS06155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RC12_RS06160	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RC12_RS06170	COG0564	pseudouridine synthase activity
RC12_RS06175	COG0772	Belongs to the SEDS family
RC12_RS06190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RC12_RS06195	COG0569	domain protein
RC12_RS06200	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
RC12_RS06205	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RC12_RS06210	COG0281	malic enzyme
RC12_RS06210	COG0280	phosphate acetyltransferase
RC12_RS06215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RC12_RS06225	COG0439	Biotin carboxylase
RC12_RS06230	COG0511	ligase activity, forming carbon-carbon bonds
RC12_RS06240	COG1086	Polysaccharide biosynthesis protein
RC12_RS06245	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RC12_RS06250	COG4310	Domain of unknown function (DUF2172)
RC12_RS06265	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RC12_RS06280	COG1083	cytidylyl-transferase
RC12_RS06285	COG3980	spore coat polysaccharide biosynthesis protein
RC12_RS06290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RC12_RS06295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RC12_RS06300	COG0107	imidazoleglycerol-phosphate synthase activity
RC12_RS06315	COG2089	acid synthase
RC12_RS06355	COG2165	general secretion pathway protein
RC12_RS06360	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RC12_RS06370	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RC12_RS06375	COG0575	Belongs to the CDS family
RC12_RS06385	COG1293	RNA-binding protein homologous to eukaryotic snRNP
RC12_RS06395	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
RC12_RS06400	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RC12_RS06405	COG4605	iron ion homeostasis
RC12_RS06410	COG4604	ABC transporter, ATP-binding protein
RC12_RS06415	COG4607	ABC-type enterochelin transport system periplasmic component
RC12_RS06430	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
RC12_RS06435	COG3005	denitrification pathway
RC12_RS06440	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RC12_RS06470	COG0628	permease
RC12_RS06475	COG0114	fumarate hydratase activity
RC12_RS06480	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RC12_RS06490	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
RC12_RS06495	COG2252	PERMEase
RC12_RS06505	COG2853	Lipoprotein
RC12_RS06525	COG2814	Major facilitator Superfamily
RC12_RS06540	COG3276	selenocysteine insertion sequence binding
RC12_RS06555	COG0716	FMN binding
RC12_RS06570	COG0753	catalase activity
RC12_RS06580	COG2964	Protein conserved in bacteria
RC12_RS06585	COG0251	oxidation-reduction process
RC12_RS06590	COG3069	C4-dicarboxylate transmembrane transporter activity
RC12_RS06610	COG1918	ferrous iron import across plasma membrane
RC12_RS06615	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
RC12_RS06620	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
RC12_RS06625	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RC12_RS06640	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RC12_RS06665	COG1580	Controls the rotational direction of flagella during chemotaxis
RC12_RS06670	COG0736	holo-[acyl-carrier-protein] synthase activity
RC12_RS06680	COG2124	cytochrome p450
RC12_RS06700	COG0529	Catalyzes the synthesis of activated sulfate
RC12_RS06705	COG1213	nucleotidyl transferase
RC12_RS06710	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RC12_RS06715	COG0574	Belongs to the PEP-utilizing enzyme family
RC12_RS06715	COG3848	Pyruvate phosphate dikinase
RC12_RS06720	COG2226	methyltransferase
RC12_RS06795	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RC12_RS06815	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RC12_RS06835	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RC12_RS06845	COG1216	Glycosyl transferase, family 2
RC12_RS06845	COG1442	glycosyl transferase family 8
RC12_RS06860	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RC12_RS06860	COG1215	transferase activity, transferring glycosyl groups
RC12_RS06870	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RC12_RS06870	COG0517	IMP dehydrogenase activity
RC12_RS06940	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RC12_RS06965	COG3951	Flagellar rod assembly protein muramidase FlgJ
RC12_RS06990	COG0730	response to heat
RC12_RS06995	COG1459	type II secretion system
RC12_RS07000	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RC12_RS07030	COG0546	phosphoglycolate phosphatase activity
RC12_RS07040	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RC12_RS07045	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RC12_RS07050	COG1074	ATP-dependent DNA helicase activity
RC12_RS07055	COG2887	Belongs to the helicase family. UvrD subfamily
RC12_RS07100	COG0745	RESPONSE REGULATOR receiver
RC12_RS07115	COG0505	Belongs to the CarA family
RC12_RS07150	COG0425	Belongs to the sulfur carrier protein TusA family
RC12_RS07155	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RC12_RS07165	COG0709	Synthesizes selenophosphate from selenide and ATP
RC12_RS07175	COG0840	transmembrane signaling receptor activity
RC12_RS07185	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RC12_RS07195	COG0437	4 iron, 4 sulfur cluster binding
RC12_RS07205	COG3383	formate dehydrogenase (NAD+) activity
RC12_RS07235	COG0314	molybdopterin synthase activity
RC12_RS07240	COG0303	'Molybdopterin
RC12_RS07245	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
RC12_RS07265	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RC12_RS07280	COG2992	FlgJ-related protein
RC12_RS07290	COG0783	Belongs to the Dps family
RC12_RS07295	COG0166	Belongs to the GPI family
RC12_RS07310	COG3839	Belongs to the ABC transporter superfamily
RC12_RS07315	COG4662	Binding-protein-dependent transport system inner membrane component
RC12_RS07320	COG2998	abc-type tungstate transport system, permease component
RC12_RS07330	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RC12_RS07335	COG1984	allophanate hydrolase subunit 2
RC12_RS07345	COG2249	NAD(P)H dehydrogenase (quinone) activity
RC12_RS07350	COG1733	regulation of RNA biosynthetic process
RC12_RS07360	COG1064	alcohol dehydrogenase
RC12_RS07400	COG2814	Major facilitator Superfamily
RC12_RS07405	COG2910	NAD(P)H-binding
RC12_RS07410	COG1733	regulation of RNA biosynthetic process
RC12_RS07420	COG0640	Transcriptional regulator
RC12_RS07455	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RC12_RS07460	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RC12_RS07470	COG0839	Belongs to the complex I subunit 6 family
RC12_RS07505	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RC12_RS07515	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RC12_RS07530	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RC12_RS07545	COG0243	molybdopterin cofactor binding
RC12_RS07550	COG0243	molybdopterin cofactor binding
RC12_RS07555	COG0243	molybdopterin cofactor binding
RC12_RS07560	COG0243	molybdopterin cofactor binding
RC12_RS07565	COG0437	4 iron, 4 sulfur cluster binding
RC12_RS07585	COG4615	Cyclic peptide transporter
RC12_RS07605	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RC12_RS07610	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RC12_RS07620	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RC12_RS07625	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RC12_RS07630	COG0202	RNA polymerase activity
RC12_RS07635	COG0203	ribosomal protein L17
RC12_RS07645	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RC12_RS07650	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RC12_RS07650	COG0131	Imidazoleglycerol-phosphate dehydratase
RC12_RS07660	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RC12_RS07675	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RC12_RS07675	COG0140	phosphoribosyl-ATP diphosphatase activity
RC12_RS07680	COG2171	N-acyltransferase activity
RC12_RS07685	COG0489	protein tyrosine kinase activity
RC12_RS07690	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RC12_RS07690	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RC12_RS07695	COG0745	RESPONSE REGULATOR receiver
RC12_RS07700	COG2046	Belongs to the sulfate adenylyltransferase family
RC12_RS07705	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RC12_RS07710	COG0268	Binds directly to 16S ribosomal RNA
RC12_RS07715	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RC12_RS07720	COG0748	coenzyme F420 binding
RC12_RS07725	COG4771	TonB-dependent receptor
RC12_RS07730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RC12_RS07735	COG1120	ATPase activity
RC12_RS07740	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RC12_RS07755	COG1194	a g-specific adenine glycosylase
RC12_RS07785	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RC12_RS07785	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RC12_RS07795	COG1760	l-serine dehydratase
RC12_RS07800	COG0814	amino acid
RC12_RS07815	COG0811	peptide transport
RC12_RS07820	COG0848	biopolymer transport protein
RC12_RS07855	COG0328	RNA-DNA hybrid ribonuclease activity
RC12_RS07865	COG0358	DNA primase activity
RC12_RS07880	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RC12_RS07885	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RC12_RS07900	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RC12_RS07905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RC12_RS07910	COG1127	ABC transporter
RC12_RS07920	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RC12_RS07920	COG3218	ABC-type transport auxiliary lipoprotein component
RC12_RS07930	COG0024	Methionine aminopeptidase
RC12_RS07935	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RC12_RS07940	COG0791	NLP P60 protein
RC12_RS07945	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RC12_RS07950	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RC12_RS07965	COG0672	)-iron permease
RC12_RS07990	COG1136	(ABC) transporter
RC12_RS08045	COG1793	dna ligase
RC12_RS08060	COG0148	phosphopyruvate hydratase activity
RC12_RS08065	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RC12_RS08070	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
RC12_RS08075	COG1987	bacterial-type flagellum assembly
RC12_RS08090	COG1218	3'(2'),5'-bisphosphate nucleotidase
RC12_RS08095	COG0372	Belongs to the citrate synthase family
RC12_RS08110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RC12_RS08125	COG1175	transmembrane transport
RC12_RS08140	COG1653	transport
RC12_RS08155	COG0201	protein transport
RC12_RS08160	COG0200	Binds to the 23S rRNA
RC12_RS08165	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RC12_RS08170	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RC12_RS08175	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RC12_RS08180	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RC12_RS08185	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RC12_RS08190	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RC12_RS08195	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RC12_RS08200	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RC12_RS08205	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RC12_RS08210	COG0255	Belongs to the universal ribosomal protein uL29 family
RC12_RS08215	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RC12_RS08220	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RC12_RS08225	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RC12_RS08230	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RC12_RS08240	COG0089	rRNA binding
RC12_RS08245	COG0088	Forms part of the polypeptide exit tunnel
RC12_RS08250	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RC12_RS08255	COG0051	transcription antitermination factor activity, RNA binding
RC12_RS08260	COG1187	pseudouridine synthase activity
RC12_RS08265	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RC12_RS08280	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RC12_RS08360	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RC12_RS08390	COG0673	inositol 2-dehydrogenase activity
RC12_RS08420	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RC12_RS08430	COG1749	Flagellar hook protein flgE
RC12_RS08440	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RC12_RS08445	COG0592	DNA-directed DNA polymerase activity
RC12_RS08450	COG0187	DNA topoisomerase II activity
RC12_RS08465	COG2056	Na+-H+ antiporter family
RC12_RS08470	COG0070	glutamate synthase
RC12_RS08470	COG0069	glutamate synthase activity
RC12_RS08470	COG0067	glutamate synthase
RC12_RS08475	COG0493	'glutamate synthase
RC12_RS08490	COG1592	Rubrerythrin
RC12_RS08500	COG3477	response to acidic pH
RC12_RS08525	COG0840	transmembrane signaling receptor activity
RC12_RS08530	COG1858	cytochrome C peroxidase
RC12_RS08535	COG0179	Fumarylacetoacetate (FAA) hydrolase
RC12_RS08540	COG0564	pseudouridine synthase activity
RC12_RS08545	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RC12_RS08550	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RC12_RS08575	COG0252	asparaginase activity