locus-tag	class	description
RC21_RS00015	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RC21_RS00025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RC21_RS00035	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RC21_RS00045	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RC21_RS00070	COG0083	homoserine kinase activity
RC21_RS00090	COG0779	Required for maturation of 30S ribosomal subunits
RC21_RS00105	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RC21_RS00110	COG1121	(ABC) transporter
RC21_RS00140	COG0492	ferredoxin-NADP+ reductase activity
RC21_RS00145	COG3118	belongs to the thioredoxin family
RC21_RS00155	COG0460	homoserine dehydrogenase
RC21_RS00160	COG0436	Aminotransferase
RC21_RS00175	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RC21_RS00180	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RC21_RS00185	COG0254	rRNA binding
RC21_RS00190	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RC21_RS00210	COG0602	queuosine metabolic process
RC21_RS00215	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RC21_RS00240	COG1971	Probably functions as a manganese efflux pump
RC21_RS00255	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RC21_RS00275	COG1840	ABC-type Fe3 transport system, periplasmic component
RC21_RS00285	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
RC21_RS00290	COG1253	flavin adenine dinucleotide binding
RC21_RS00300	COG2824	Alkylphosphonate utilization operon protein PhnA
RC21_RS00305	COG0861	Integral membrane protein TerC family
RC21_RS00310	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RC21_RS00315	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RC21_RS00315	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RC21_RS00325	COG0606	chelatase, subunit chli
RC21_RS00330	COG0242	peptide deformylase activity
RC21_RS00350	COG1157	protein secretion by the type III secretion system
RC21_RS00355	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RC21_RS00365	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RC21_RS00365	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RC21_RS00380	COG2851	Citrate transporter
RC21_RS00385	COG1297	OPT oligopeptide transporter protein
RC21_RS00400	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RC21_RS00435	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RC21_RS00440	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RC21_RS00445	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RC21_RS00460	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RC21_RS00480	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RC21_RS00485	COG0670	Belongs to the BI1 family
RC21_RS00490	COG0288	reversible hydration of carbon dioxide
RC21_RS00495	COG0668	transmembrane transport
RC21_RS00520	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RC21_RS00525	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RC21_RS00530	COG3290	protein histidine kinase activity
RC21_RS00530	COG0840	transmembrane signaling receptor activity
RC21_RS00565	COG2921	Belongs to the UPF0250 family
RC21_RS00575	COG0708	Exodeoxyribonuclease III
RC21_RS00580	COG2194	sulfuric ester hydrolase activity
RC21_RS00585	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RC21_RS00595	COG0418	dihydroorotase activity
RC21_RS00605	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RC21_RS00615	COG2856	Zn peptidase
RC21_RS00635	COG0428	transporter
RC21_RS00655	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RC21_RS00675	COG1028	Short-chain dehydrogenase reductase Sdr
RC21_RS00685	COG1053	succinate dehydrogenase
RC21_RS00690	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RC21_RS00695	COG2048	Heterodisulfide reductase, subunit B
RC21_RS00700	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RC21_RS00705	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RC21_RS00710	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RC21_RS00720	COG4771	TonB-dependent receptor
RC21_RS00725	COG0494	nUDIX hydrolase
RC21_RS00740	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RC21_RS00745	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RC21_RS00775	COG2121	Domain of unknown function (DUF374)
RC21_RS00790	COG0195	Participates in both transcription termination and antitermination
RC21_RS00800	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
RC21_RS00805	COG0612	Peptidase, M16
RC21_RS00810	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RC21_RS00815	COG2346	COG2346, Truncated hemoglobins
RC21_RS00830	COG0765	amino acid transport
RC21_RS00860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RC21_RS00865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RC21_RS00880	COG0250	Participates in transcription elongation, termination and antitermination
RC21_RS00885	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RC21_RS00890	COG0081	regulation of translation
RC21_RS00895	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RC21_RS00900	COG0222	ribosome binding
RC21_RS00915	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RC21_RS00920	COG0049	tRNA binding
RC21_RS00955	COG0134	indole-3-glycerol-phosphate synthase activity
RC21_RS00965	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
RC21_RS00970	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RC21_RS00975	COG0673	inositol 2-dehydrogenase activity
RC21_RS00985	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RC21_RS00990	COG0424	maF-like protein
RC21_RS01000	COG0542	response to heat
RC21_RS01005	COG1937	Protein conserved in bacteria
RC21_RS01010	COG0793	Belongs to the peptidase S41A family
RC21_RS01015	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RC21_RS01020	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RC21_RS01025	COG0047	phosphoribosylformylglycinamidine synthase activity
RC21_RS01035	COG0204	Acyl-transferase
RC21_RS01045	COG0326	Molecular chaperone. Has ATPase activity
RC21_RS01050	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RC21_RS01070	COG1677	Flagellar hook-basal body complex protein FliE
RC21_RS01075	COG1558	bacterial-type flagellum-dependent cell motility
RC21_RS01080	COG1815	bacterial-type flagellum-dependent cell motility
RC21_RS01100	COG0039	L-malate dehydrogenase activity
RC21_RS01110	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RC21_RS01120	COG0674	pyruvate-flavodoxin oxidoreductase activity
RC21_RS01120	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RC21_RS01125	COG1013	pyruvate-flavodoxin oxidoreductase activity
RC21_RS01145	COG0142	geranyltranstransferase activity
RC21_RS01165	COG0181	hydroxymethylbilane synthase activity
RC21_RS01170	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RC21_RS01180	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RC21_RS01200	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RC21_RS01230	COG1289	transmembrane transporter activity
RC21_RS01235	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RC21_RS01240	COG0492	ferredoxin-NADP+ reductase activity
RC21_RS01255	COG0305	Participates in initiation and elongation during chromosome replication
RC21_RS01275	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RC21_RS01275	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RC21_RS01280	COG1610	YqeY-like protein
RC21_RS01285	COG0028	Belongs to the TPP enzyme family
RC21_RS01290	COG0440	acetolactate synthase activity
RC21_RS01300	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RC21_RS01305	COG0805	protein transport
RC21_RS01315	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RC21_RS01320	COG0494	nUDIX hydrolase
RC21_RS01325	COG0527	aspartate kinase activity
RC21_RS01340	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RC21_RS01360	COG0196	riboflavin kinase activity
RC21_RS01365	COG2890	protein-(glutamine-N5) methyltransferase activity
RC21_RS01380	COG2860	membrane
RC21_RS01390	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RC21_RS01395	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RC21_RS01400	COG0191	fructose-bisphosphate aldolase activity
RC21_RS01420	COG0733	neurotransmitter:sodium symporter activity
RC21_RS01440	COG1473	amidohydrolase
RC21_RS01445	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RC21_RS01450	COG1136	(ABC) transporter
RC21_RS01450	COG0577	efflux transmembrane transporter activity
RC21_RS01455	COG1538	Outer membrane efflux protein
RC21_RS01470	COG1696	Membrane protein involved in D-alanine export
RC21_RS01475	COG1528	Iron-storage protein
RC21_RS01480	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RC21_RS01485	COG0573	inorganic phosphate transmembrane transporter activity
RC21_RS01490	COG0581	inorganic phosphate transmembrane transporter activity
RC21_RS01500	COG0534	Mate efflux family protein
RC21_RS01515	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
RC21_RS01525	COG0298	carbon dioxide binding
RC21_RS01530	COG0409	Hydrogenase expression formation protein
RC21_RS01535	COG0309	Hydrogenase expression formation protein (HypE)
RC21_RS01540	COG0375	protein maturation
RC21_RS01550	COG0557	exoribonuclease II activity
RC21_RS01555	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RC21_RS01565	COG0758	DNA mediated transformation
RC21_RS01580	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RC21_RS01585	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RC21_RS01590	COG0563	adenylate kinase activity
RC21_RS01595	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RC21_RS01605	COG0497	DNA recombination
RC21_RS01615	COG0084	hydrolase, TatD family'
RC21_RS01620	COG1388	LysM domain
RC21_RS01620	COG0791	NLP P60 protein
RC21_RS01625	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RC21_RS01955	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RC21_RS01975	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RC21_RS01980	COG0802	atpase or kinase
RC21_RS01985	COG1137	ATPase activity
RC21_RS01990	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RC21_RS01995	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RC21_RS02000	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RC21_RS02005	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RC21_RS02010	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
RC21_RS02015	COG2205	protein histidine kinase activity
RC21_RS02020	COG0556	nucleotide-excision repair
RC21_RS02040	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RC21_RS02045	COG1213	nucleotidyl transferase
RC21_RS02065	COG0529	Catalyzes the synthesis of activated sulfate
RC21_RS02070	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RC21_RS02080	COG0280	phosphate acetyltransferase
RC21_RS02105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RC21_RS02110	COG0849	cell division
RC21_RS02115	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RC21_RS02120	COG4786	Flagellar basal body rod
RC21_RS02125	COG4786	Flagellar basal body rod
RC21_RS02130	COG0174	glutamine synthetase
RC21_RS02140	COG0826	peptidase U32
RC21_RS02145	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RC21_RS02155	COG0752	glycyl-tRNA synthetase alpha subunit
RC21_RS02160	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RC21_RS02170	COG1519	Transferase
RC21_RS02170	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RC21_RS02175	COG0564	pseudouridine synthase activity
RC21_RS02180	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RC21_RS02185	COG0228	four-way junction DNA binding
RC21_RS02190	COG1837	Belongs to the UPF0109 family
RC21_RS02195	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RC21_RS02200	COG0336	Belongs to the RNA methyltransferase TrmD family
RC21_RS02205	COG0335	large ribosomal subunit rRNA binding
RC21_RS02215	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
RC21_RS02220	COG1393	Belongs to the ArsC family
RC21_RS02225	COG0587	DNA-directed DNA polymerase activity
RC21_RS02230	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RC21_RS02245	COG2890	protein-(glutamine-N5) methyltransferase activity
RC21_RS02260	COG0521	Mo-molybdopterin cofactor biosynthetic process
RC21_RS02265	COG0598	Magnesium transport protein CorA
RC21_RS02285	COG1178	ABC-type Fe3 transport system permease component
RC21_RS02340	COG1420	regulation of RNA biosynthetic process
RC21_RS02390	COG0436	Aminotransferase
RC21_RS02395	COG1045	serine acetyltransferase
RC21_RS02400	COG1166	arginine decarboxylase activity
RC21_RS02415	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RC21_RS02420	COG0163	prenyltransferase activity
RC21_RS02430	COG1464	Belongs to the NlpA lipoprotein family
RC21_RS02435	COG1464	Belongs to the NlpA lipoprotein family
RC21_RS02440	COG1464	Belongs to the NlpA lipoprotein family
RC21_RS02445	COG2011	ABC-type metal ion transport system permease component
RC21_RS02450	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RC21_RS02465	COG0210	DNA helicase
RC21_RS02475	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
RC21_RS02485	COG0437	4 iron, 4 sulfur cluster binding
RC21_RS02490	COG0348	domain, Protein
RC21_RS02495	COG3043	anaerobic respiration
RC21_RS02530	COG0788	formyltetrahydrofolate deformylase activity
RC21_RS02535	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RC21_RS02545	COG0642	Histidine kinase
RC21_RS02550	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RC21_RS02565	COG1181	Belongs to the D-alanine--D-alanine ligase family
RC21_RS02570	COG0632	four-way junction helicase activity
RC21_RS02580	COG0728	peptidoglycan biosynthetic process
RC21_RS02590	COG1132	(ABC) transporter
RC21_RS02595	COG0167	dihydroorotate dehydrogenase activity
RC21_RS02600	COG0612	Peptidase, M16
RC21_RS02610	COG1028	Short-chain dehydrogenase reductase Sdr
RC21_RS02625	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RC21_RS02635	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RC21_RS02640	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RC21_RS02655	COG0330	HflC and HflK could
RC21_RS02665	COG1942	4-Oxalocrotonate Tautomerase
RC21_RS02670	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RC21_RS02675	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RC21_RS02690	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RC21_RS02695	COG1077	Cell shape determining protein MreB Mrl
RC21_RS02705	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RC21_RS02725	COG0835	chemotaxis
RC21_RS02730	COG0784	Response regulator, receiver
RC21_RS02730	COG0643	Histidine kinase
RC21_RS02730	COG2198	Histidine kinase
RC21_RS02735	COG0784	Response regulator, receiver
RC21_RS02735	COG0835	chemotaxis
RC21_RS02745	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RC21_RS02750	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RC21_RS02800	COG4106	trans-aconitate 2-methyltransferase activity
RC21_RS02805	COG2830	Protein of unknown function (DUF452)
RC21_RS02815	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RC21_RS02820	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RC21_RS02825	COG2076	Multidrug Resistance protein
RC21_RS02840	COG0193	aminoacyl-tRNA hydrolase activity
RC21_RS02850	COG0019	diaminopimelate decarboxylase activity
RC21_RS02875	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RC21_RS02885	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RC21_RS02910	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RC21_RS02915	COG0251	oxidation-reduction process
RC21_RS02920	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RC21_RS02930	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RC21_RS02950	COG0450	alkyl hydroperoxide reductase
RC21_RS02955	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RC21_RS02960	COG1360	Flagellar Motor Protein
RC21_RS02965	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RC21_RS02975	COG0477	Major facilitator Superfamily
RC21_RS02985	COG1238	metal cluster binding
RC21_RS02990	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RC21_RS02995	COG0730	response to heat
RC21_RS03010	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RC21_RS03010	COG0512	Glutamine amidotransferase of anthranilate synthase
RC21_RS03020	COG0133	tryptophan synthase activity
RC21_RS03035	COG1776	CheC inhibitor of MCP methylation
RC21_RS03035	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RC21_RS03050	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RC21_RS03055	COG0745	RESPONSE REGULATOR receiver
RC21_RS03075	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RC21_RS03085	COG1981	membrane
RC21_RS03090	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RC21_RS03100	COG1538	Outer membrane efflux protein
RC21_RS03110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RC21_RS03125	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RC21_RS03135	COG0754	glutathionylspermidine amidase activity
RC21_RS03140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RC21_RS03160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RC21_RS03165	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RC21_RS03170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RC21_RS03175	COG0284	orotidine-5'-phosphate decarboxylase activity
RC21_RS03180	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RC21_RS03185	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RC21_RS03190	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RC21_RS03200	COG1160	GTP binding
RC21_RS03235	COG0579	oxidoreductase
RC21_RS03240	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RC21_RS03260	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RC21_RS03295	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RC21_RS03315	COG1053	succinate dehydrogenase
RC21_RS03320	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RC21_RS03395	COG0488	(ABC) transporter
RC21_RS03410	COG1739	Uncharacterized protein family UPF0029
RC21_RS03475	COG2814	Major facilitator Superfamily
RC21_RS03495	COG1217	gtp-binding protein TYPA
RC21_RS03510	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
RC21_RS03545	COG1611	Belongs to the LOG family
RC21_RS03550	COG1776	CheC inhibitor of MCP methylation
RC21_RS03550	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RC21_RS03555	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RC21_RS03560	COG1191	sigma factor activity
RC21_RS03570	COG0455	bacterial-type flagellum organization
RC21_RS03575	COG1419	protein localization to endoplasmic reticulum
RC21_RS03580	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RC21_RS03585	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RC21_RS03590	COG0402	S-adenosylhomocysteine deaminase activity
RC21_RS03595	COG0616	signal peptide processing
RC21_RS03620	COG1139	Iron-sulfur cluster binding protein
RC21_RS03625	COG0247	lactate metabolic process
RC21_RS03655	COG1271	oxidase subunit
RC21_RS03660	COG1294	oxidase, subunit
RC21_RS03680	COG1794	racemase activity, acting on amino acids and derivatives
RC21_RS03685	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RC21_RS03690	COG1027	Aspartate ammonia-lyase
RC21_RS03695	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RC21_RS03725	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RC21_RS03730	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RC21_RS03745	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RC21_RS03750	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
RC21_RS03750	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
RC21_RS03755	COG1192	Involved in chromosome partitioning
RC21_RS03760	COG1475	DNA binding
RC21_RS03770	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RC21_RS03775	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RC21_RS03790	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RC21_RS03800	COG0811	peptide transport
RC21_RS03805	COG0848	biopolymer transport protein
RC21_RS03820	COG2885	chlorophyll binding
RC21_RS03830	COG1047	Peptidyl-prolyl cis-trans
RC21_RS03835	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RC21_RS03840	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RC21_RS03845	COG0037	tRNA processing
RC21_RS03860	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RC21_RS03885	COG1338	Plays a role in the flagellum-specific transport system
RC21_RS03920	COG0101	tRNA pseudouridine synthase activity
RC21_RS03925	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RC21_RS03945	COG1757	Na H antiporter
RC21_RS03950	COG4221	oxidoreductase activity
RC21_RS03960	COG1049	propionate catabolic process, 2-methylcitrate cycle
RC21_RS03965	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RC21_RS03975	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RC21_RS03975	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RC21_RS03985	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RC21_RS04010	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RC21_RS04015	COG1408	metallophosphoesterase
RC21_RS04020	COG0688	phosphatidylethanolamine metabolic process
RC21_RS04060	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RC21_RS04065	COG0681	Belongs to the peptidase S26 family
RC21_RS04070	COG0303	'Molybdopterin
RC21_RS04090	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RC21_RS04090	COG0512	Glutamine amidotransferase of anthranilate synthase
RC21_RS04095	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RC21_RS04100	COG0582	viral genome integration into host DNA
RC21_RS04110	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RC21_RS04125	COG3258	Cytochrome c
RC21_RS04150	COG2404	hydrolase activity, acting on ester bonds
RC21_RS04155	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RC21_RS04160	COG1959	2 iron, 2 sulfur cluster binding
RC21_RS04165	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RC21_RS04170	COG1196	nuclear chromosome segregation
RC21_RS04170	COG1674	ftsk spoiiie
RC21_RS04175	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RC21_RS04190	COG0488	(ABC) transporter
RC21_RS04195	COG5002	protein histidine kinase activity
RC21_RS04200	COG0745	RESPONSE REGULATOR receiver
RC21_RS04205	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RC21_RS04215	COG1185	polyribonucleotide nucleotidyltransferase activity
RC21_RS04215	COG0539	negative regulation of cytoplasmic translation
RC21_RS04230	COG0072	phenylalanine-tRNA ligase activity
RC21_RS04230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RC21_RS04235	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RC21_RS04240	COG0537	adenosine 5'-monophosphoramidase activity
RC21_RS04255	COG0765	amino acid transport
RC21_RS04265	COG1115	amino acid carrier protein
RC21_RS04270	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RC21_RS04305	COG1999	signal sequence binding
RC21_RS04310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RC21_RS04315	COG0776	regulation of translation
RC21_RS04335	COG1966	Carbon starvation protein
RC21_RS04340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RC21_RS04345	COG0765	amino acid transport
RC21_RS04350	COG0765	amino acid transport
RC21_RS04355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RC21_RS04360	COG1126	abc transporter atp-binding protein
RC21_RS04365	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RC21_RS04370	COG2201	protein-glutamate methylesterase activity
RC21_RS04395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RC21_RS04400	COG0012	GTP binding
RC21_RS04415	COG5016	pyruvate
RC21_RS04415	COG0511	ligase activity, forming carbon-carbon bonds
RC21_RS04420	COG0733	neurotransmitter:sodium symporter activity
RC21_RS04425	COG0733	neurotransmitter:sodium symporter activity
RC21_RS04470	COG0318	PFAM AMP-dependent synthetase and ligase
RC21_RS04470	COG0204	Acyl-transferase
RC21_RS04515	COG0765	amino acid transport
RC21_RS04525	COG0653	protein targeting
RC21_RS04530	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RC21_RS04540	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RC21_RS04555	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RC21_RS04570	COG0840	transmembrane signaling receptor activity
RC21_RS04575	COG0138	bifunctional purine biosynthesis protein purh
RC21_RS04580	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RC21_RS04600	COG0706	membrane insertase activity
RC21_RS04605	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RC21_RS04615	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RC21_RS04635	COG0824	Thioesterase
RC21_RS04665	COG2703	oxygen carrier activity
RC21_RS04670	COG0500	methyltransferase
RC21_RS04690	COG2195	Cleaves the N-terminal amino acid of tripeptides
RC21_RS04695	COG0477	Major facilitator Superfamily
RC21_RS04700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RC21_RS04710	COG3022	response to hydroperoxide
RC21_RS04715	COG1473	amidohydrolase
RC21_RS04730	COG2807	transmembrane transport
RC21_RS04750	COG0247	lactate metabolic process
RC21_RS04750	COG2181	nitrate reductase activity
RC21_RS04755	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RC21_RS04765	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RC21_RS04770	COG0113	porphobilinogen synthase activity
RC21_RS04775	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RC21_RS04780	COG0357	Ribosomal RNA small subunit methyltransferase G
RC21_RS04790	COG2855	membrane
RC21_RS04795	COG0583	DNA-binding transcription factor activity
RC21_RS04800	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RC21_RS04820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RC21_RS04825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RC21_RS04835	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RC21_RS04845	COG0343	queuine tRNA-ribosyltransferase activity
RC21_RS04865	COG1333	cytochrome c biogenesis protein
RC21_RS04865	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RC21_RS04915	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RC21_RS04920	COG2204	response regulator
RC21_RS04935	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RC21_RS04950	COG0481	GTPase activity
RC21_RS04975	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RC21_RS04985	COG0439	Biotin carboxylase
RC21_RS04990	COG0772	Belongs to the SEDS family
RC21_RS04995	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RC21_RS05015	COG0352	thiamine-phosphate diphosphorylase activity
RC21_RS05020	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RC21_RS05025	COG2022	thiamine diphosphate biosynthetic process
RC21_RS05045	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RC21_RS05060	COG1193	negative regulation of DNA recombination
RC21_RS05085	COG0517	IMP dehydrogenase activity
RC21_RS05085	COG0516	GMP reductase activity
RC21_RS05090	COG0154	amidase activity
RC21_RS05100	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RC21_RS05105	COG1546	Belongs to the CinA family
RC21_RS05105	COG1058	Belongs to the CinA family
RC21_RS05115	COG0778	Nitroreductase
RC21_RS05120	COG0778	Nitroreductase
RC21_RS05130	COG0750	zinc metalloprotease
RC21_RS05135	COG2990	Protein conserved in bacteria
RC21_RS05140	COG0360	Binds together with S18 to 16S ribosomal RNA
RC21_RS05145	COG0629	single-stranded DNA binding
RC21_RS05150	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RC21_RS05155	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RC21_RS05165	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
RC21_RS05170	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RC21_RS05195	COG0352	thiamine-phosphate diphosphorylase activity
RC21_RS05215	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RC21_RS05225	COG0739	heme binding
RC21_RS05230	COG0285	dihydrofolate synthase activity
RC21_RS05250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RC21_RS05255	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RC21_RS05260	COG1862	Preprotein translocase
RC21_RS05265	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RC21_RS05270	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RC21_RS05295	COG0210	DNA helicase
RC21_RS05315	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RC21_RS05325	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RC21_RS05330	COG0542	response to heat
RC21_RS05335	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RC21_RS05345	COG2095	MarC family integral membrane protein
RC21_RS05350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RC21_RS05355	COG2833	Protein of unknown function (DUF455)
RC21_RS05360	COG1183	phosphatidylcholine synthase activity
RC21_RS05370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RC21_RS05380	COG0745	RESPONSE REGULATOR receiver
RC21_RS05390	COG1086	Polysaccharide biosynthesis protein
RC21_RS05395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RC21_RS05400	COG0110	maltose O-acetyltransferase activity
RC21_RS05405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RC21_RS05410	COG0438	transferase activity, transferring glycosyl groups
RC21_RS05415	COG1287	oligosaccharyl transferase activity
RC21_RS05420	COG0438	transferase activity, transferring glycosyl groups
RC21_RS05425	COG1215	transferase activity, transferring glycosyl groups
RC21_RS05430	COG0438	transferase activity, transferring glycosyl groups
RC21_RS05435	COG1132	(ABC) transporter
RC21_RS05440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RC21_RS05450	COG0859	PFAM glycosyl transferase family 9
RC21_RS05455	COG1560	Kdo2-lipid A biosynthetic process
RC21_RS05460	COG0463	Glycosyl transferase, family 2
RC21_RS05465	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RC21_RS05490	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RC21_RS05530	COG1216	Glycosyl transferase, family 2
RC21_RS05540	COG1696	Membrane protein involved in D-alanine export
RC21_RS05555	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RC21_RS05555	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RC21_RS05565	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RC21_RS05580	COG2217	Heavy metal translocating P-type atpase
RC21_RS05585	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RC21_RS05590	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RC21_RS05600	COG2217	Heavy metal translocating P-type atpase
RC21_RS05620	COG3610	response to peptide
RC21_RS05630	COG0586	Pfam SNARE associated Golgi protein
RC21_RS05645	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RC21_RS05665	COG0018	arginyl-trna synthetase
RC21_RS05670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RC21_RS05675	COG0194	GDP metabolic process
RC21_RS05685	COG1684	flagellar biosynthetic protein fliR
RC21_RS05690	COG1136	(ABC) transporter
RC21_RS05695	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RC21_RS05700	COG0052	Belongs to the universal ribosomal protein uS2 family
RC21_RS05705	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RC21_RS05715	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RC21_RS05720	COG0723	plastoquinol--plastocyanin reductase activity
RC21_RS05725	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RC21_RS05750	COG1301	dicarboxylic acid transport
RC21_RS05765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RC21_RS05770	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RC21_RS05780	COG1854	S-ribosylhomocysteine lyase activity
RC21_RS05790	COG1464	Belongs to the NlpA lipoprotein family
RC21_RS05800	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RC21_RS05815	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RC21_RS05820	COG0552	protein localization to endoplasmic reticulum
RC21_RS05850	COG1295	ribonuclease BN
RC21_RS05855	COG0277	FAD linked oxidase domain protein
RC21_RS05865	COG0739	heme binding
RC21_RS05875	COG1496	oxidoreductase activity
RC21_RS05890	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RC21_RS05900	COG0642	Histidine kinase
RC21_RS05905	COG0745	RESPONSE REGULATOR receiver
RC21_RS05910	COG2703	oxygen carrier activity
RC21_RS05925	COG0642	Histidine kinase
RC21_RS05930	COG0745	RESPONSE REGULATOR receiver
RC21_RS05940	COG0484	heat shock protein binding
RC21_RS05945	COG0789	Transcriptional regulator
RC21_RS05950	COG0475	glutathione-regulated potassium exporter activity
RC21_RS05950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RC21_RS05960	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RC21_RS05965	COG0751	glycine-tRNA ligase activity
RC21_RS05970	COG0739	heme binding
RC21_RS05980	COG0248	Ppx GppA phosphatase
RC21_RS05990	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RC21_RS06000	COG2814	Major facilitator Superfamily
RC21_RS06015	COG0731	radical SAM domain protein
RC21_RS06085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RC21_RS06090	COG4773	Receptor
RC21_RS06100	COG0745	RESPONSE REGULATOR receiver
RC21_RS06105	COG0642	Histidine kinase
RC21_RS06110	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RC21_RS06115	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RC21_RS06120	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
RC21_RS06125	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
RC21_RS06130	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
RC21_RS06150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RC21_RS06155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RC21_RS06160	COG1758	RNA polymerase activity
RC21_RS06165	COG0528	UMP kinase activity
RC21_RS06180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RC21_RS06185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RC21_RS06195	COG0564	pseudouridine synthase activity
RC21_RS06200	COG0772	Belongs to the SEDS family
RC21_RS06215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RC21_RS06220	COG0569	domain protein
RC21_RS06225	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
RC21_RS06230	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RC21_RS06235	COG0280	phosphate acetyltransferase
RC21_RS06235	COG0281	malic enzyme
RC21_RS06240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RC21_RS06250	COG0439	Biotin carboxylase
RC21_RS06255	COG0511	ligase activity, forming carbon-carbon bonds
RC21_RS06265	COG1086	Polysaccharide biosynthesis protein
RC21_RS06270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RC21_RS06275	COG4310	Domain of unknown function (DUF2172)
RC21_RS06290	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RC21_RS06305	COG1083	cytidylyl-transferase
RC21_RS06310	COG3980	spore coat polysaccharide biosynthesis protein
RC21_RS06315	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RC21_RS06320	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RC21_RS06325	COG0107	imidazoleglycerol-phosphate synthase activity
RC21_RS06340	COG2089	acid synthase
RC21_RS06380	COG2165	general secretion pathway protein
RC21_RS06385	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RC21_RS06395	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RC21_RS06400	COG0575	Belongs to the CDS family
RC21_RS06410	COG1293	RNA-binding protein homologous to eukaryotic snRNP
RC21_RS06420	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
RC21_RS06425	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RC21_RS06430	COG4605	iron ion homeostasis
RC21_RS06435	COG4604	ABC transporter, ATP-binding protein
RC21_RS06440	COG4607	ABC-type enterochelin transport system periplasmic component
RC21_RS06455	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
RC21_RS06460	COG3005	denitrification pathway
RC21_RS06465	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RC21_RS06495	COG0628	permease
RC21_RS06500	COG0114	fumarate hydratase activity
RC21_RS06505	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RC21_RS06515	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
RC21_RS06520	COG2252	PERMEase
RC21_RS06530	COG2853	Lipoprotein
RC21_RS06550	COG2814	Major facilitator Superfamily
RC21_RS06565	COG3276	selenocysteine insertion sequence binding
RC21_RS06580	COG0716	FMN binding
RC21_RS06595	COG0753	catalase activity
RC21_RS06605	COG2964	Protein conserved in bacteria
RC21_RS06610	COG0251	oxidation-reduction process
RC21_RS06615	COG3069	C4-dicarboxylate transmembrane transporter activity
RC21_RS06635	COG1918	ferrous iron import across plasma membrane
RC21_RS06640	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
RC21_RS06645	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
RC21_RS06650	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RC21_RS06665	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RC21_RS06690	COG1580	Controls the rotational direction of flagella during chemotaxis
RC21_RS06695	COG0736	holo-[acyl-carrier-protein] synthase activity
RC21_RS06705	COG2124	cytochrome p450
RC21_RS06725	COG0529	Catalyzes the synthesis of activated sulfate
RC21_RS06730	COG1213	nucleotidyl transferase
RC21_RS06735	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RC21_RS06740	COG0574	Belongs to the PEP-utilizing enzyme family
RC21_RS06740	COG3848	Pyruvate phosphate dikinase
RC21_RS06745	COG2226	methyltransferase
RC21_RS06820	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RC21_RS06840	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RC21_RS06860	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RC21_RS06870	COG1216	Glycosyl transferase, family 2
RC21_RS06870	COG1442	glycosyl transferase family 8
RC21_RS06885	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RC21_RS06885	COG1215	transferase activity, transferring glycosyl groups
RC21_RS06895	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RC21_RS06895	COG0517	IMP dehydrogenase activity
RC21_RS06965	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RC21_RS06990	COG3951	Flagellar rod assembly protein muramidase FlgJ
RC21_RS07015	COG0730	response to heat
RC21_RS07020	COG1459	type II secretion system
RC21_RS07025	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RC21_RS07055	COG0546	phosphoglycolate phosphatase activity
RC21_RS07065	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RC21_RS07070	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RC21_RS07075	COG1074	ATP-dependent DNA helicase activity
RC21_RS07080	COG2887	Belongs to the helicase family. UvrD subfamily
RC21_RS07125	COG0745	RESPONSE REGULATOR receiver
RC21_RS07140	COG0505	Belongs to the CarA family
RC21_RS07175	COG0425	Belongs to the sulfur carrier protein TusA family
RC21_RS07180	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RC21_RS07190	COG0709	Synthesizes selenophosphate from selenide and ATP
RC21_RS07200	COG0840	transmembrane signaling receptor activity
RC21_RS07210	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RC21_RS07220	COG0437	4 iron, 4 sulfur cluster binding
RC21_RS07230	COG3383	formate dehydrogenase (NAD+) activity
RC21_RS07260	COG0314	molybdopterin synthase activity
RC21_RS07265	COG0303	'Molybdopterin
RC21_RS07270	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
RC21_RS07290	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RC21_RS07305	COG2992	FlgJ-related protein
RC21_RS07315	COG0783	Belongs to the Dps family
RC21_RS07320	COG0166	Belongs to the GPI family
RC21_RS07335	COG3839	Belongs to the ABC transporter superfamily
RC21_RS07340	COG4662	Binding-protein-dependent transport system inner membrane component
RC21_RS07345	COG2998	abc-type tungstate transport system, permease component
RC21_RS07355	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RC21_RS07360	COG1984	allophanate hydrolase subunit 2
RC21_RS07370	COG2249	NAD(P)H dehydrogenase (quinone) activity
RC21_RS07375	COG1733	regulation of RNA biosynthetic process
RC21_RS07385	COG1064	alcohol dehydrogenase
RC21_RS07425	COG2814	Major facilitator Superfamily
RC21_RS07430	COG2910	NAD(P)H-binding
RC21_RS07435	COG1733	regulation of RNA biosynthetic process
RC21_RS07445	COG0640	Transcriptional regulator
RC21_RS07475	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RC21_RS07480	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RC21_RS07490	COG0839	Belongs to the complex I subunit 6 family
RC21_RS07525	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RC21_RS07535	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RC21_RS07550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RC21_RS07565	COG0243	molybdopterin cofactor binding
RC21_RS07570	COG0243	molybdopterin cofactor binding
RC21_RS07575	COG0243	molybdopterin cofactor binding
RC21_RS07580	COG0243	molybdopterin cofactor binding
RC21_RS07585	COG0437	4 iron, 4 sulfur cluster binding
RC21_RS07605	COG4615	Cyclic peptide transporter
RC21_RS07625	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RC21_RS07630	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RC21_RS07640	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RC21_RS07645	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RC21_RS07650	COG0202	RNA polymerase activity
RC21_RS07655	COG0203	ribosomal protein L17
RC21_RS07665	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RC21_RS07670	COG0131	Imidazoleglycerol-phosphate dehydratase
RC21_RS07670	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RC21_RS07680	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RC21_RS07695	COG0140	phosphoribosyl-ATP diphosphatase activity
RC21_RS07695	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RC21_RS07700	COG2171	N-acyltransferase activity
RC21_RS07705	COG0489	protein tyrosine kinase activity
RC21_RS07710	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RC21_RS07710	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RC21_RS07715	COG0745	RESPONSE REGULATOR receiver
RC21_RS07720	COG2046	Belongs to the sulfate adenylyltransferase family
RC21_RS07725	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RC21_RS07730	COG0268	Binds directly to 16S ribosomal RNA
RC21_RS07735	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RC21_RS07740	COG0748	coenzyme F420 binding
RC21_RS07745	COG4771	TonB-dependent receptor
RC21_RS07750	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RC21_RS07755	COG1120	ATPase activity
RC21_RS07760	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RC21_RS07775	COG1194	a g-specific adenine glycosylase
RC21_RS07805	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RC21_RS07805	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RC21_RS07815	COG1760	l-serine dehydratase
RC21_RS07820	COG0814	amino acid
RC21_RS07835	COG0811	peptide transport
RC21_RS07840	COG0848	biopolymer transport protein
RC21_RS07875	COG0328	RNA-DNA hybrid ribonuclease activity
RC21_RS07885	COG0358	DNA primase activity
RC21_RS07900	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RC21_RS07905	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RC21_RS07920	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RC21_RS07925	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RC21_RS07930	COG1127	ABC transporter
RC21_RS07940	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RC21_RS07940	COG3218	ABC-type transport auxiliary lipoprotein component
RC21_RS07950	COG0024	Methionine aminopeptidase
RC21_RS07955	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RC21_RS07960	COG0791	NLP P60 protein
RC21_RS07965	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RC21_RS07970	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RC21_RS07985	COG0672	)-iron permease
RC21_RS08010	COG1136	(ABC) transporter
RC21_RS08065	COG1793	dna ligase
RC21_RS08080	COG0148	phosphopyruvate hydratase activity
RC21_RS08085	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RC21_RS08090	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
RC21_RS08095	COG1987	bacterial-type flagellum assembly
RC21_RS08110	COG1218	3'(2'),5'-bisphosphate nucleotidase
RC21_RS08115	COG0372	Belongs to the citrate synthase family
RC21_RS08130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RC21_RS08145	COG1175	transmembrane transport
RC21_RS08160	COG1653	transport
RC21_RS08175	COG0201	protein transport
RC21_RS08180	COG0200	Binds to the 23S rRNA
RC21_RS08185	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RC21_RS08190	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RC21_RS08195	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RC21_RS08200	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RC21_RS08205	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RC21_RS08210	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RC21_RS08215	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RC21_RS08220	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RC21_RS08225	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RC21_RS08230	COG0255	Belongs to the universal ribosomal protein uL29 family
RC21_RS08235	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RC21_RS08240	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RC21_RS08245	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RC21_RS08250	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RC21_RS08260	COG0089	rRNA binding
RC21_RS08265	COG0088	Forms part of the polypeptide exit tunnel
RC21_RS08270	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RC21_RS08275	COG0051	transcription antitermination factor activity, RNA binding
RC21_RS08280	COG1187	pseudouridine synthase activity
RC21_RS08285	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RC21_RS08300	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RC21_RS08380	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RC21_RS08410	COG0673	inositol 2-dehydrogenase activity
RC21_RS08440	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RC21_RS08450	COG1749	Flagellar hook protein flgE
RC21_RS08460	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RC21_RS08465	COG0592	DNA-directed DNA polymerase activity
RC21_RS08470	COG0187	DNA topoisomerase II activity
RC21_RS08485	COG2056	Na+-H+ antiporter family
RC21_RS08490	COG0067	glutamate synthase
RC21_RS08490	COG0070	glutamate synthase
RC21_RS08490	COG0069	glutamate synthase activity
RC21_RS08495	COG0493	'glutamate synthase
RC21_RS08510	COG1592	Rubrerythrin
RC21_RS08520	COG3477	response to acidic pH
RC21_RS08545	COG0840	transmembrane signaling receptor activity
RC21_RS08550	COG1858	cytochrome C peroxidase
RC21_RS08555	COG0179	Fumarylacetoacetate (FAA) hydrolase
RC21_RS08560	COG0564	pseudouridine synthase activity
RC21_RS08565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RC21_RS08570	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RC21_RS08595	COG0252	asparaginase activity