locus-tag	class	description
RC33_RS00010	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
RC33_RS00020	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
RC33_RS00030	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
RC33_RS00040	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
RC33_RS00065	COG0083	homoserine kinase activity
RC33_RS00085	COG0779	Required for maturation of 30S ribosomal subunits
RC33_RS00100	COG1108	ABC-type Mn2 Zn2 transport systems permease components
RC33_RS00105	COG1121	(ABC) transporter
RC33_RS00135	COG0492	ferredoxin-NADP+ reductase activity
RC33_RS00140	COG3118	belongs to the thioredoxin family
RC33_RS00150	COG0460	homoserine dehydrogenase
RC33_RS00155	COG0436	Aminotransferase
RC33_RS00170	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
RC33_RS00175	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
RC33_RS00180	COG0254	rRNA binding
RC33_RS00185	COG1385	rRNA (uridine-N3-)-methyltransferase activity
RC33_RS00205	COG0602	queuosine metabolic process
RC33_RS00210	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
RC33_RS00235	COG1971	Probably functions as a manganese efflux pump
RC33_RS00250	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
RC33_RS00270	COG1840	ABC-type Fe3 transport system, periplasmic component
RC33_RS00280	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
RC33_RS00285	COG1253	flavin adenine dinucleotide binding
RC33_RS00295	COG2824	Alkylphosphonate utilization operon protein PhnA
RC33_RS00300	COG0861	Integral membrane protein TerC family
RC33_RS00305	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
RC33_RS00310	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
RC33_RS00310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
RC33_RS00320	COG0606	chelatase, subunit chli
RC33_RS00325	COG0242	peptide deformylase activity
RC33_RS00345	COG1157	protein secretion by the type III secretion system
RC33_RS00350	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
RC33_RS00360	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
RC33_RS00360	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
RC33_RS00375	COG2851	Citrate transporter
RC33_RS00380	COG1297	OPT oligopeptide transporter protein
RC33_RS00395	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
RC33_RS00430	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
RC33_RS00435	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
RC33_RS00440	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
RC33_RS00455	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RC33_RS00475	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
RC33_RS00480	COG0670	Belongs to the BI1 family
RC33_RS00485	COG0288	reversible hydration of carbon dioxide
RC33_RS00490	COG0668	transmembrane transport
RC33_RS00515	COG0291	Belongs to the bacterial ribosomal protein bL35 family
RC33_RS00520	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
RC33_RS00525	COG0840	transmembrane signaling receptor activity
RC33_RS00525	COG3290	protein histidine kinase activity
RC33_RS00560	COG2921	Belongs to the UPF0250 family
RC33_RS00570	COG0708	Exodeoxyribonuclease III
RC33_RS00575	COG2194	sulfuric ester hydrolase activity
RC33_RS00580	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
RC33_RS00590	COG0418	dihydroorotase activity
RC33_RS00600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
RC33_RS00610	COG2856	Zn peptidase
RC33_RS00630	COG0428	transporter
RC33_RS00660	COG0330	HflC and HflK could
RC33_RS00670	COG1942	4-Oxalocrotonate Tautomerase
RC33_RS00675	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
RC33_RS00680	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
RC33_RS00695	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
RC33_RS00700	COG1077	Cell shape determining protein MreB Mrl
RC33_RS00710	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
RC33_RS00730	COG0835	chemotaxis
RC33_RS00735	COG0643	Histidine kinase
RC33_RS00735	COG2198	Histidine kinase
RC33_RS00735	COG0784	Response regulator, receiver
RC33_RS00740	COG0784	Response regulator, receiver
RC33_RS00740	COG0835	chemotaxis
RC33_RS00750	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
RC33_RS00755	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
RC33_RS00805	COG4106	trans-aconitate 2-methyltransferase activity
RC33_RS00810	COG2830	Protein of unknown function (DUF452)
RC33_RS00820	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
RC33_RS00825	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
RC33_RS00830	COG2076	Multidrug Resistance protein
RC33_RS00845	COG0193	aminoacyl-tRNA hydrolase activity
RC33_RS00855	COG0019	diaminopimelate decarboxylase activity
RC33_RS00880	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RC33_RS00890	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
RC33_RS00915	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
RC33_RS00920	COG0251	oxidation-reduction process
RC33_RS00925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
RC33_RS00935	COG0333	Belongs to the bacterial ribosomal protein bL32 family
RC33_RS00955	COG0450	alkyl hydroperoxide reductase
RC33_RS00960	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RC33_RS00965	COG1360	Flagellar Motor Protein
RC33_RS00970	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
RC33_RS00980	COG0477	Major facilitator Superfamily
RC33_RS00990	COG1238	metal cluster binding
RC33_RS00995	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
RC33_RS01000	COG0730	response to heat
RC33_RS01015	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RC33_RS01015	COG0512	Glutamine amidotransferase of anthranilate synthase
RC33_RS01025	COG0133	tryptophan synthase activity
RC33_RS01040	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RC33_RS01040	COG1776	CheC inhibitor of MCP methylation
RC33_RS01055	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
RC33_RS01060	COG0745	RESPONSE REGULATOR receiver
RC33_RS01080	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
RC33_RS01090	COG1981	membrane
RC33_RS01095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RC33_RS01105	COG1538	Outer membrane efflux protein
RC33_RS01115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RC33_RS01130	COG0828	Belongs to the bacterial ribosomal protein bS21 family
RC33_RS01140	COG0754	glutathionylspermidine amidase activity
RC33_RS01145	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
RC33_RS01165	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RC33_RS01170	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
RC33_RS01175	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
RC33_RS01180	COG0284	orotidine-5'-phosphate decarboxylase activity
RC33_RS01185	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
RC33_RS01190	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
RC33_RS01195	COG2877	3-deoxy-8-phosphooctulonate synthase activity
RC33_RS01205	COG1160	GTP binding
RC33_RS01240	COG0579	oxidoreductase
RC33_RS01245	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
RC33_RS01265	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
RC33_RS01300	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
RC33_RS01320	COG1053	succinate dehydrogenase
RC33_RS01325	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RC33_RS01400	COG0488	(ABC) transporter
RC33_RS01415	COG1739	Uncharacterized protein family UPF0029
RC33_RS01435	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
RC33_RS01455	COG1028	Short-chain dehydrogenase reductase Sdr
RC33_RS01465	COG1053	succinate dehydrogenase
RC33_RS01470	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
RC33_RS01475	COG2048	Heterodisulfide reductase, subunit B
RC33_RS01480	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
RC33_RS01485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
RC33_RS01490	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
RC33_RS01500	COG4771	TonB-dependent receptor
RC33_RS01505	COG0494	nUDIX hydrolase
RC33_RS01520	COG0227	Belongs to the bacterial ribosomal protein bL28 family
RC33_RS01525	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
RC33_RS01555	COG2121	Domain of unknown function (DUF374)
RC33_RS01570	COG0195	Participates in both transcription termination and antitermination
RC33_RS01580	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
RC33_RS01585	COG0612	Peptidase, M16
RC33_RS01590	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
RC33_RS01595	COG2346	COG2346, Truncated hemoglobins
RC33_RS01610	COG0765	amino acid transport
RC33_RS01640	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
RC33_RS01645	COG0267	Belongs to the bacterial ribosomal protein bL33 family
RC33_RS01660	COG0250	Participates in transcription elongation, termination and antitermination
RC33_RS01665	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
RC33_RS01670	COG0081	regulation of translation
RC33_RS01675	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
RC33_RS01680	COG0222	ribosome binding
RC33_RS01695	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
RC33_RS01700	COG0049	tRNA binding
RC33_RS01735	COG0134	indole-3-glycerol-phosphate synthase activity
RC33_RS01745	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
RC33_RS01750	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
RC33_RS01755	COG0673	inositol 2-dehydrogenase activity
RC33_RS01765	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
RC33_RS01770	COG0424	maF-like protein
RC33_RS01780	COG0542	response to heat
RC33_RS01785	COG1937	Protein conserved in bacteria
RC33_RS01790	COG0793	Belongs to the peptidase S41A family
RC33_RS01795	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
RC33_RS01800	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
RC33_RS01805	COG0047	phosphoribosylformylglycinamidine synthase activity
RC33_RS01815	COG0204	Acyl-transferase
RC33_RS01825	COG0326	Molecular chaperone. Has ATPase activity
RC33_RS01830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
RC33_RS01850	COG1677	Flagellar hook-basal body complex protein FliE
RC33_RS01855	COG1558	bacterial-type flagellum-dependent cell motility
RC33_RS01860	COG1815	bacterial-type flagellum-dependent cell motility
RC33_RS01880	COG0039	L-malate dehydrogenase activity
RC33_RS01890	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
RC33_RS01900	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
RC33_RS01900	COG0674	pyruvate-flavodoxin oxidoreductase activity
RC33_RS01905	COG1013	pyruvate-flavodoxin oxidoreductase activity
RC33_RS01925	COG0142	geranyltranstransferase activity
RC33_RS01945	COG0181	hydroxymethylbilane synthase activity
RC33_RS01950	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
RC33_RS01960	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
RC33_RS01980	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
RC33_RS02010	COG1289	transmembrane transporter activity
RC33_RS02015	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
RC33_RS02020	COG0492	ferredoxin-NADP+ reductase activity
RC33_RS02035	COG0305	Participates in initiation and elongation during chromosome replication
RC33_RS02055	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RC33_RS02055	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RC33_RS02060	COG1610	YqeY-like protein
RC33_RS02065	COG0028	Belongs to the TPP enzyme family
RC33_RS02070	COG0440	acetolactate synthase activity
RC33_RS02080	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
RC33_RS02085	COG0805	protein transport
RC33_RS02095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RC33_RS02100	COG0494	nUDIX hydrolase
RC33_RS02105	COG0527	aspartate kinase activity
RC33_RS02120	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
RC33_RS02140	COG0196	riboflavin kinase activity
RC33_RS02145	COG2890	protein-(glutamine-N5) methyltransferase activity
RC33_RS02160	COG2860	membrane
RC33_RS02170	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
RC33_RS02175	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RC33_RS02180	COG0191	fructose-bisphosphate aldolase activity
RC33_RS02200	COG0733	neurotransmitter:sodium symporter activity
RC33_RS02220	COG1473	amidohydrolase
RC33_RS02225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
RC33_RS02230	COG1136	(ABC) transporter
RC33_RS02230	COG0577	efflux transmembrane transporter activity
RC33_RS02235	COG1538	Outer membrane efflux protein
RC33_RS02250	COG1696	Membrane protein involved in D-alanine export
RC33_RS02255	COG1528	Iron-storage protein
RC33_RS02260	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
RC33_RS02265	COG0573	inorganic phosphate transmembrane transporter activity
RC33_RS02270	COG0581	inorganic phosphate transmembrane transporter activity
RC33_RS02280	COG0534	Mate efflux family protein
RC33_RS02295	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
RC33_RS02305	COG0298	carbon dioxide binding
RC33_RS02310	COG0409	Hydrogenase expression formation protein
RC33_RS02315	COG0309	Hydrogenase expression formation protein (HypE)
RC33_RS02320	COG0375	protein maturation
RC33_RS02330	COG0557	exoribonuclease II activity
RC33_RS02335	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
RC33_RS02345	COG0758	DNA mediated transformation
RC33_RS02360	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RC33_RS02365	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
RC33_RS02370	COG0563	adenylate kinase activity
RC33_RS02375	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
RC33_RS02385	COG0497	DNA recombination
RC33_RS02395	COG0084	hydrolase, TatD family'
RC33_RS02400	COG0791	NLP P60 protein
RC33_RS02400	COG1388	LysM domain
RC33_RS02405	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
RC33_RS02640	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
RC33_RS02660	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
RC33_RS02665	COG0802	atpase or kinase
RC33_RS02670	COG1137	ATPase activity
RC33_RS02675	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
RC33_RS02680	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RC33_RS02685	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
RC33_RS02690	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
RC33_RS02695	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
RC33_RS02700	COG2205	protein histidine kinase activity
RC33_RS02705	COG0556	nucleotide-excision repair
RC33_RS02725	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
RC33_RS02730	COG1213	nucleotidyl transferase
RC33_RS02745	COG0529	Catalyzes the synthesis of activated sulfate
RC33_RS02750	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
RC33_RS02760	COG0280	phosphate acetyltransferase
RC33_RS02785	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
RC33_RS02790	COG0849	cell division
RC33_RS02795	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
RC33_RS02800	COG4786	Flagellar basal body rod
RC33_RS02805	COG4786	Flagellar basal body rod
RC33_RS02810	COG0174	glutamine synthetase
RC33_RS02820	COG0826	peptidase U32
RC33_RS02825	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
RC33_RS02835	COG0752	glycyl-tRNA synthetase alpha subunit
RC33_RS02840	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
RC33_RS02850	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RC33_RS02850	COG1519	Transferase
RC33_RS02855	COG0564	pseudouridine synthase activity
RC33_RS02860	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
RC33_RS02865	COG0228	four-way junction DNA binding
RC33_RS02870	COG1837	Belongs to the UPF0109 family
RC33_RS02875	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
RC33_RS02880	COG0336	Belongs to the RNA methyltransferase TrmD family
RC33_RS02885	COG0335	large ribosomal subunit rRNA binding
RC33_RS02895	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
RC33_RS02900	COG1393	Belongs to the ArsC family
RC33_RS02905	COG0587	DNA-directed DNA polymerase activity
RC33_RS02910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
RC33_RS02925	COG2890	protein-(glutamine-N5) methyltransferase activity
RC33_RS02940	COG0521	Mo-molybdopterin cofactor biosynthetic process
RC33_RS02945	COG0598	Magnesium transport protein CorA
RC33_RS02965	COG1178	ABC-type Fe3 transport system permease component
RC33_RS03050	COG1420	regulation of RNA biosynthetic process
RC33_RS03100	COG0436	Aminotransferase
RC33_RS03105	COG1045	serine acetyltransferase
RC33_RS03110	COG1166	arginine decarboxylase activity
RC33_RS03125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
RC33_RS03130	COG0163	prenyltransferase activity
RC33_RS03140	COG1464	Belongs to the NlpA lipoprotein family
RC33_RS03145	COG1464	Belongs to the NlpA lipoprotein family
RC33_RS03150	COG1464	Belongs to the NlpA lipoprotein family
RC33_RS03155	COG2011	ABC-type metal ion transport system permease component
RC33_RS03160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RC33_RS03175	COG0210	DNA helicase
RC33_RS03185	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
RC33_RS03195	COG0437	4 iron, 4 sulfur cluster binding
RC33_RS03200	COG0348	domain, Protein
RC33_RS03205	COG3043	anaerobic respiration
RC33_RS03240	COG0788	formyltetrahydrofolate deformylase activity
RC33_RS03245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
RC33_RS03255	COG0642	Histidine kinase
RC33_RS03265	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
RC33_RS03280	COG1181	Belongs to the D-alanine--D-alanine ligase family
RC33_RS03285	COG0632	four-way junction helicase activity
RC33_RS03295	COG0728	peptidoglycan biosynthetic process
RC33_RS03305	COG1132	(ABC) transporter
RC33_RS03310	COG0167	dihydroorotate dehydrogenase activity
RC33_RS03315	COG0612	Peptidase, M16
RC33_RS03325	COG1028	Short-chain dehydrogenase reductase Sdr
RC33_RS03340	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
RC33_RS03350	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
RC33_RS03355	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
RC33_RS03385	COG2814	Major facilitator Superfamily
RC33_RS03405	COG1217	gtp-binding protein TYPA
RC33_RS03420	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
RC33_RS03455	COG1611	Belongs to the LOG family
RC33_RS03460	COG1776	CheC inhibitor of MCP methylation
RC33_RS03460	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RC33_RS03465	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
RC33_RS03470	COG1191	sigma factor activity
RC33_RS03480	COG0455	bacterial-type flagellum organization
RC33_RS03485	COG1419	protein localization to endoplasmic reticulum
RC33_RS03490	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
RC33_RS03495	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
RC33_RS03500	COG0402	S-adenosylhomocysteine deaminase activity
RC33_RS03505	COG0616	signal peptide processing
RC33_RS03530	COG1139	Iron-sulfur cluster binding protein
RC33_RS03535	COG0247	lactate metabolic process
RC33_RS03565	COG1271	oxidase subunit
RC33_RS03570	COG1294	oxidase, subunit
RC33_RS03590	COG1794	racemase activity, acting on amino acids and derivatives
RC33_RS03595	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
RC33_RS03600	COG1027	Aspartate ammonia-lyase
RC33_RS03605	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
RC33_RS03635	COG0261	This protein binds to 23S rRNA in the presence of protein L20
RC33_RS03640	COG0211	Belongs to the bacterial ribosomal protein bL27 family
RC33_RS03655	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RC33_RS03660	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
RC33_RS03660	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
RC33_RS03665	COG1192	Involved in chromosome partitioning
RC33_RS03670	COG1475	DNA binding
RC33_RS03680	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
RC33_RS03685	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
RC33_RS03700	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
RC33_RS03710	COG0811	peptide transport
RC33_RS03715	COG0848	biopolymer transport protein
RC33_RS03730	COG2885	chlorophyll binding
RC33_RS03740	COG1047	Peptidyl-prolyl cis-trans
RC33_RS03745	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
RC33_RS03750	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
RC33_RS03755	COG0037	tRNA processing
RC33_RS03770	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
RC33_RS03795	COG1338	Plays a role in the flagellum-specific transport system
RC33_RS03830	COG0101	tRNA pseudouridine synthase activity
RC33_RS03835	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
RC33_RS03855	COG1757	Na H antiporter
RC33_RS03860	COG4221	oxidoreductase activity
RC33_RS03870	COG1049	propionate catabolic process, 2-methylcitrate cycle
RC33_RS03875	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
RC33_RS03885	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RC33_RS03885	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RC33_RS03895	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
RC33_RS03920	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RC33_RS03925	COG1408	metallophosphoesterase
RC33_RS03930	COG0688	phosphatidylethanolamine metabolic process
RC33_RS03970	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
RC33_RS03975	COG0681	Belongs to the peptidase S26 family
RC33_RS03980	COG0303	'Molybdopterin
RC33_RS04000	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
RC33_RS04000	COG0512	Glutamine amidotransferase of anthranilate synthase
RC33_RS04005	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
RC33_RS04010	COG0582	viral genome integration into host DNA
RC33_RS04020	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
RC33_RS04035	COG3258	Cytochrome c
RC33_RS04060	COG2404	hydrolase activity, acting on ester bonds
RC33_RS04065	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
RC33_RS04070	COG1959	2 iron, 2 sulfur cluster binding
RC33_RS04075	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
RC33_RS04080	COG1196	nuclear chromosome segregation
RC33_RS04080	COG1674	ftsk spoiiie
RC33_RS04085	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
RC33_RS04100	COG0488	(ABC) transporter
RC33_RS04105	COG5002	protein histidine kinase activity
RC33_RS04110	COG0745	RESPONSE REGULATOR receiver
RC33_RS04115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
RC33_RS04125	COG1185	polyribonucleotide nucleotidyltransferase activity
RC33_RS04125	COG0539	negative regulation of cytoplasmic translation
RC33_RS04140	COG0072	phenylalanine-tRNA ligase activity
RC33_RS04140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
RC33_RS04145	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
RC33_RS04150	COG0537	adenosine 5'-monophosphoramidase activity
RC33_RS04165	COG0765	amino acid transport
RC33_RS04175	COG1115	amino acid carrier protein
RC33_RS04180	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
RC33_RS04215	COG1999	signal sequence binding
RC33_RS04220	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
RC33_RS04225	COG0776	regulation of translation
RC33_RS04245	COG1966	Carbon starvation protein
RC33_RS04250	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
RC33_RS04255	COG0765	amino acid transport
RC33_RS04260	COG0765	amino acid transport
RC33_RS04265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RC33_RS04270	COG1126	abc transporter atp-binding protein
RC33_RS04275	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
RC33_RS04280	COG2201	protein-glutamate methylesterase activity
RC33_RS04305	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
RC33_RS04310	COG0012	GTP binding
RC33_RS04325	COG5016	pyruvate
RC33_RS04325	COG0511	ligase activity, forming carbon-carbon bonds
RC33_RS04330	COG0733	neurotransmitter:sodium symporter activity
RC33_RS04335	COG0733	neurotransmitter:sodium symporter activity
RC33_RS04385	COG0318	PFAM AMP-dependent synthetase and ligase
RC33_RS04385	COG0204	Acyl-transferase
RC33_RS04430	COG0765	amino acid transport
RC33_RS04440	COG0653	protein targeting
RC33_RS04445	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
RC33_RS04455	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
RC33_RS04470	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
RC33_RS04485	COG0840	transmembrane signaling receptor activity
RC33_RS04490	COG0138	bifunctional purine biosynthesis protein purh
RC33_RS04495	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
RC33_RS04515	COG0706	membrane insertase activity
RC33_RS04520	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
RC33_RS04530	COG0230	Belongs to the bacterial ribosomal protein bL34 family
RC33_RS04550	COG0824	Thioesterase
RC33_RS04580	COG2703	oxygen carrier activity
RC33_RS04585	COG0500	methyltransferase
RC33_RS04605	COG2195	Cleaves the N-terminal amino acid of tripeptides
RC33_RS04610	COG0477	Major facilitator Superfamily
RC33_RS04615	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
RC33_RS04625	COG3022	response to hydroperoxide
RC33_RS04630	COG1473	amidohydrolase
RC33_RS04645	COG2807	transmembrane transport
RC33_RS04665	COG0247	lactate metabolic process
RC33_RS04665	COG2181	nitrate reductase activity
RC33_RS04670	COG0635	Involved in the biosynthesis of porphyrin-containing compound
RC33_RS04680	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
RC33_RS04685	COG0113	porphobilinogen synthase activity
RC33_RS04690	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
RC33_RS04695	COG0357	Ribosomal RNA small subunit methyltransferase G
RC33_RS04705	COG2855	membrane
RC33_RS04710	COG0583	DNA-binding transcription factor activity
RC33_RS04715	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
RC33_RS04735	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RC33_RS04740	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
RC33_RS04750	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
RC33_RS04760	COG0343	queuine tRNA-ribosyltransferase activity
RC33_RS04780	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
RC33_RS04780	COG1333	cytochrome c biogenesis protein
RC33_RS04830	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
RC33_RS04835	COG2204	response regulator
RC33_RS04850	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
RC33_RS04865	COG0481	GTPase activity
RC33_RS04890	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
RC33_RS04900	COG0439	Biotin carboxylase
RC33_RS04905	COG0772	Belongs to the SEDS family
RC33_RS04910	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
RC33_RS04930	COG0352	thiamine-phosphate diphosphorylase activity
RC33_RS04935	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
RC33_RS04940	COG2022	thiamine diphosphate biosynthetic process
RC33_RS04960	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
RC33_RS04975	COG1193	negative regulation of DNA recombination
RC33_RS05000	COG0516	GMP reductase activity
RC33_RS05000	COG0517	IMP dehydrogenase activity
RC33_RS05005	COG0154	amidase activity
RC33_RS05015	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
RC33_RS05020	COG1546	Belongs to the CinA family
RC33_RS05020	COG1058	Belongs to the CinA family
RC33_RS05030	COG0778	Nitroreductase
RC33_RS05035	COG0778	Nitroreductase
RC33_RS05045	COG0750	zinc metalloprotease
RC33_RS05050	COG2990	Protein conserved in bacteria
RC33_RS05055	COG0360	Binds together with S18 to 16S ribosomal RNA
RC33_RS05060	COG0629	single-stranded DNA binding
RC33_RS05065	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
RC33_RS05070	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
RC33_RS05080	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
RC33_RS05085	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
RC33_RS05110	COG0352	thiamine-phosphate diphosphorylase activity
RC33_RS05130	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
RC33_RS05140	COG0739	heme binding
RC33_RS05145	COG0285	dihydrofolate synthase activity
RC33_RS05165	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RC33_RS05170	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
RC33_RS05175	COG1862	Preprotein translocase
RC33_RS05180	COG0815	Transfers the fatty acyl group on membrane lipoproteins
RC33_RS05185	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
RC33_RS05210	COG0210	DNA helicase
RC33_RS05230	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
RC33_RS05240	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
RC33_RS05245	COG0542	response to heat
RC33_RS05250	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
RC33_RS05260	COG2095	MarC family integral membrane protein
RC33_RS05265	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
RC33_RS05270	COG2833	Protein of unknown function (DUF455)
RC33_RS05275	COG1183	phosphatidylcholine synthase activity
RC33_RS05285	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
RC33_RS05295	COG0745	RESPONSE REGULATOR receiver
RC33_RS05305	COG1086	Polysaccharide biosynthesis protein
RC33_RS05310	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RC33_RS05315	COG0110	maltose O-acetyltransferase activity
RC33_RS05320	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
RC33_RS05325	COG0438	transferase activity, transferring glycosyl groups
RC33_RS05330	COG1287	oligosaccharyl transferase activity
RC33_RS05335	COG0438	transferase activity, transferring glycosyl groups
RC33_RS05340	COG1215	transferase activity, transferring glycosyl groups
RC33_RS05345	COG0438	transferase activity, transferring glycosyl groups
RC33_RS05350	COG1132	(ABC) transporter
RC33_RS05355	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
RC33_RS05365	COG0859	PFAM glycosyl transferase family 9
RC33_RS05370	COG1560	Kdo2-lipid A biosynthetic process
RC33_RS05375	COG0463	Glycosyl transferase, family 2
RC33_RS05380	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
RC33_RS05405	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RC33_RS05445	COG1216	Glycosyl transferase, family 2
RC33_RS05455	COG1696	Membrane protein involved in D-alanine export
RC33_RS05470	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
RC33_RS05470	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
RC33_RS05480	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RC33_RS05495	COG2217	Heavy metal translocating P-type atpase
RC33_RS05500	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
RC33_RS05505	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
RC33_RS05515	COG2217	Heavy metal translocating P-type atpase
RC33_RS05535	COG3610	response to peptide
RC33_RS05545	COG0586	Pfam SNARE associated Golgi protein
RC33_RS05560	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
RC33_RS05580	COG0018	arginyl-trna synthetase
RC33_RS05585	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
RC33_RS05590	COG0194	GDP metabolic process
RC33_RS05600	COG1684	flagellar biosynthetic protein fliR
RC33_RS05605	COG1136	(ABC) transporter
RC33_RS05610	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
RC33_RS05615	COG0052	Belongs to the universal ribosomal protein uS2 family
RC33_RS05620	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
RC33_RS05630	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
RC33_RS05635	COG0723	plastoquinol--plastocyanin reductase activity
RC33_RS05640	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
RC33_RS05665	COG1301	dicarboxylic acid transport
RC33_RS05680	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
RC33_RS05685	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
RC33_RS05695	COG1854	S-ribosylhomocysteine lyase activity
RC33_RS05705	COG1464	Belongs to the NlpA lipoprotein family
RC33_RS05715	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
RC33_RS05730	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
RC33_RS05735	COG0552	protein localization to endoplasmic reticulum
RC33_RS05765	COG1295	ribonuclease BN
RC33_RS05770	COG0277	FAD linked oxidase domain protein
RC33_RS05780	COG0739	heme binding
RC33_RS05790	COG1496	oxidoreductase activity
RC33_RS05805	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
RC33_RS05815	COG0642	Histidine kinase
RC33_RS05820	COG0745	RESPONSE REGULATOR receiver
RC33_RS05825	COG2703	oxygen carrier activity
RC33_RS05840	COG0642	Histidine kinase
RC33_RS05845	COG0745	RESPONSE REGULATOR receiver
RC33_RS05855	COG0484	heat shock protein binding
RC33_RS05860	COG0789	Transcriptional regulator
RC33_RS05865	COG0475	glutathione-regulated potassium exporter activity
RC33_RS05865	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
RC33_RS05875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RC33_RS05880	COG0751	glycine-tRNA ligase activity
RC33_RS05885	COG0739	heme binding
RC33_RS05895	COG0248	Ppx GppA phosphatase
RC33_RS05905	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
RC33_RS05915	COG2814	Major facilitator Superfamily
RC33_RS05930	COG0731	radical SAM domain protein
RC33_RS06000	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
RC33_RS06005	COG4773	Receptor
RC33_RS06015	COG0745	RESPONSE REGULATOR receiver
RC33_RS06020	COG0642	Histidine kinase
RC33_RS06025	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
RC33_RS06030	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
RC33_RS06035	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
RC33_RS06040	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
RC33_RS06045	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
RC33_RS06065	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
RC33_RS06070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
RC33_RS06075	COG1758	RNA polymerase activity
RC33_RS06080	COG0528	UMP kinase activity
RC33_RS06095	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
RC33_RS06100	COG0220	tRNA (guanine-N7-)-methyltransferase activity
RC33_RS06110	COG0564	pseudouridine synthase activity
RC33_RS06115	COG0772	Belongs to the SEDS family
RC33_RS06130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
RC33_RS06135	COG0569	domain protein
RC33_RS06140	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
RC33_RS06145	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
RC33_RS06150	COG0281	malic enzyme
RC33_RS06150	COG0280	phosphate acetyltransferase
RC33_RS06155	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
RC33_RS06165	COG0439	Biotin carboxylase
RC33_RS06170	COG0511	ligase activity, forming carbon-carbon bonds
RC33_RS06180	COG1086	Polysaccharide biosynthesis protein
RC33_RS06185	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
RC33_RS06205	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
RC33_RS06220	COG1083	cytidylyl-transferase
RC33_RS06225	COG3980	spore coat polysaccharide biosynthesis protein
RC33_RS06230	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RC33_RS06235	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
RC33_RS06240	COG0107	imidazoleglycerol-phosphate synthase activity
RC33_RS06255	COG2089	acid synthase
RC33_RS06290	COG2165	general secretion pathway protein
RC33_RS06295	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
RC33_RS06305	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
RC33_RS06310	COG0575	Belongs to the CDS family
RC33_RS06320	COG1293	RNA-binding protein homologous to eukaryotic snRNP
RC33_RS06330	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
RC33_RS06335	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RC33_RS06340	COG4605	iron ion homeostasis
RC33_RS06345	COG4604	ABC transporter, ATP-binding protein
RC33_RS06350	COG4607	ABC-type enterochelin transport system periplasmic component
RC33_RS06365	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
RC33_RS06370	COG3005	denitrification pathway
RC33_RS06375	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
RC33_RS06405	COG0628	permease
RC33_RS06410	COG0114	fumarate hydratase activity
RC33_RS06415	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
RC33_RS06425	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
RC33_RS06430	COG2252	PERMEase
RC33_RS06440	COG2853	Lipoprotein
RC33_RS06460	COG2814	Major facilitator Superfamily
RC33_RS06475	COG3276	selenocysteine insertion sequence binding
RC33_RS06490	COG0716	FMN binding
RC33_RS06505	COG0753	catalase activity
RC33_RS06515	COG2964	Protein conserved in bacteria
RC33_RS06520	COG0251	oxidation-reduction process
RC33_RS06525	COG3069	C4-dicarboxylate transmembrane transporter activity
RC33_RS06545	COG1918	ferrous iron import across plasma membrane
RC33_RS06550	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
RC33_RS06555	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
RC33_RS06560	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
RC33_RS06575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
RC33_RS06600	COG1580	Controls the rotational direction of flagella during chemotaxis
RC33_RS06605	COG0736	holo-[acyl-carrier-protein] synthase activity
RC33_RS06615	COG2124	cytochrome p450
RC33_RS06635	COG0529	Catalyzes the synthesis of activated sulfate
RC33_RS06640	COG1213	nucleotidyl transferase
RC33_RS06645	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
RC33_RS06650	COG3848	Pyruvate phosphate dikinase
RC33_RS06650	COG0574	Belongs to the PEP-utilizing enzyme family
RC33_RS06655	COG2226	methyltransferase
RC33_RS06670	COG1442	glycosyl transferase family 8
RC33_RS06670	COG1216	Glycosyl transferase, family 2
RC33_RS06680	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
RC33_RS06700	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
RC33_RS06720	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
RC33_RS06800	COG1215	transferase activity, transferring glycosyl groups
RC33_RS06800	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
RC33_RS06810	COG0517	IMP dehydrogenase activity
RC33_RS06810	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
RC33_RS06880	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
RC33_RS06905	COG3951	Flagellar rod assembly protein muramidase FlgJ
RC33_RS06930	COG0730	response to heat
RC33_RS06935	COG1459	type II secretion system
RC33_RS06940	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
RC33_RS06970	COG0546	phosphoglycolate phosphatase activity
RC33_RS06980	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
RC33_RS06985	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
RC33_RS06990	COG1074	ATP-dependent DNA helicase activity
RC33_RS06995	COG2887	Belongs to the helicase family. UvrD subfamily
RC33_RS07040	COG0745	RESPONSE REGULATOR receiver
RC33_RS07055	COG0505	Belongs to the CarA family
RC33_RS07090	COG0425	Belongs to the sulfur carrier protein TusA family
RC33_RS07095	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
RC33_RS07105	COG0709	Synthesizes selenophosphate from selenide and ATP
RC33_RS07115	COG0840	transmembrane signaling receptor activity
RC33_RS07125	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
RC33_RS07135	COG0437	4 iron, 4 sulfur cluster binding
RC33_RS07145	COG3383	formate dehydrogenase (NAD+) activity
RC33_RS07175	COG0314	molybdopterin synthase activity
RC33_RS07180	COG0303	'Molybdopterin
RC33_RS07185	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
RC33_RS07205	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
RC33_RS07220	COG2992	FlgJ-related protein
RC33_RS07230	COG0783	Belongs to the Dps family
RC33_RS07235	COG0166	Belongs to the GPI family
RC33_RS07250	COG3839	Belongs to the ABC transporter superfamily
RC33_RS07255	COG4662	Binding-protein-dependent transport system inner membrane component
RC33_RS07260	COG2998	abc-type tungstate transport system, permease component
RC33_RS07270	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
RC33_RS07275	COG1984	allophanate hydrolase subunit 2
RC33_RS07285	COG2249	NAD(P)H dehydrogenase (quinone) activity
RC33_RS07290	COG1733	regulation of RNA biosynthetic process
RC33_RS07300	COG1064	alcohol dehydrogenase
RC33_RS07340	COG2814	Major facilitator Superfamily
RC33_RS07345	COG2910	NAD(P)H-binding
RC33_RS07350	COG1733	regulation of RNA biosynthetic process
RC33_RS07360	COG0640	Transcriptional regulator
RC33_RS07385	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RC33_RS07390	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
RC33_RS07400	COG0839	Belongs to the complex I subunit 6 family
RC33_RS07435	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RC33_RS07445	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
RC33_RS07460	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
RC33_RS07475	COG0243	molybdopterin cofactor binding
RC33_RS07480	COG0243	molybdopterin cofactor binding
RC33_RS07485	COG0243	molybdopterin cofactor binding
RC33_RS07490	COG0243	molybdopterin cofactor binding
RC33_RS07495	COG0437	4 iron, 4 sulfur cluster binding
RC33_RS07515	COG4615	Cyclic peptide transporter
RC33_RS07535	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
RC33_RS07540	COG0257	Belongs to the bacterial ribosomal protein bL36 family
RC33_RS07550	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
RC33_RS07555	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
RC33_RS07560	COG0202	RNA polymerase activity
RC33_RS07565	COG0203	ribosomal protein L17
RC33_RS07575	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
RC33_RS07580	COG0131	Imidazoleglycerol-phosphate dehydratase
RC33_RS07580	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
RC33_RS07590	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
RC33_RS07605	COG0140	phosphoribosyl-ATP diphosphatase activity
RC33_RS07605	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
RC33_RS07610	COG2171	N-acyltransferase activity
RC33_RS07615	COG0489	protein tyrosine kinase activity
RC33_RS07620	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
RC33_RS07620	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
RC33_RS07625	COG0745	RESPONSE REGULATOR receiver
RC33_RS07630	COG2046	Belongs to the sulfate adenylyltransferase family
RC33_RS07635	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
RC33_RS07640	COG0268	Binds directly to 16S ribosomal RNA
RC33_RS07645	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
RC33_RS07650	COG0748	coenzyme F420 binding
RC33_RS07655	COG4771	TonB-dependent receptor
RC33_RS07660	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
RC33_RS07665	COG1120	ATPase activity
RC33_RS07670	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
RC33_RS07685	COG1194	a g-specific adenine glycosylase
RC33_RS07715	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RC33_RS07715	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
RC33_RS07725	COG1760	l-serine dehydratase
RC33_RS07730	COG0814	amino acid
RC33_RS07745	COG0811	peptide transport
RC33_RS07750	COG0848	biopolymer transport protein
RC33_RS07785	COG0328	RNA-DNA hybrid ribonuclease activity
RC33_RS07795	COG0358	DNA primase activity
RC33_RS07810	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
RC33_RS07815	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
RC33_RS07830	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
RC33_RS07835	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
RC33_RS07840	COG1127	ABC transporter
RC33_RS07850	COG3218	ABC-type transport auxiliary lipoprotein component
RC33_RS07850	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
RC33_RS07860	COG0024	Methionine aminopeptidase
RC33_RS07865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
RC33_RS07870	COG0791	NLP P60 protein
RC33_RS07875	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RC33_RS07880	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
RC33_RS07895	COG0672	)-iron permease
RC33_RS07920	COG1136	(ABC) transporter
RC33_RS08010	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
RC33_RS08090	COG1793	dna ligase
RC33_RS08105	COG0148	phosphopyruvate hydratase activity
RC33_RS08110	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
RC33_RS08115	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
RC33_RS08120	COG1987	bacterial-type flagellum assembly
RC33_RS08135	COG1218	3'(2'),5'-bisphosphate nucleotidase
RC33_RS08140	COG0372	Belongs to the citrate synthase family
RC33_RS08155	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
RC33_RS08170	COG1175	transmembrane transport
RC33_RS08185	COG1653	transport
RC33_RS08200	COG0201	protein transport
RC33_RS08205	COG0200	Binds to the 23S rRNA
RC33_RS08210	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
RC33_RS08215	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
RC33_RS08220	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
RC33_RS08225	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
RC33_RS08230	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
RC33_RS08235	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
RC33_RS08240	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
RC33_RS08245	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
RC33_RS08250	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
RC33_RS08255	COG0255	Belongs to the universal ribosomal protein uL29 family
RC33_RS08260	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
RC33_RS08265	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
RC33_RS08270	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
RC33_RS08275	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
RC33_RS08285	COG0089	rRNA binding
RC33_RS08290	COG0088	Forms part of the polypeptide exit tunnel
RC33_RS08295	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
RC33_RS08300	COG0051	transcription antitermination factor activity, RNA binding
RC33_RS08305	COG1187	pseudouridine synthase activity
RC33_RS08310	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
RC33_RS08325	COG0820	rRNA (adenine-C2-)-methyltransferase activity
RC33_RS08370	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
RC33_RS08400	COG0673	inositol 2-dehydrogenase activity
RC33_RS08430	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
RC33_RS08440	COG1749	Flagellar hook protein flgE
RC33_RS08450	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
RC33_RS08455	COG0592	DNA-directed DNA polymerase activity
RC33_RS08460	COG0187	DNA topoisomerase II activity
RC33_RS08475	COG2056	Na+-H+ antiporter family
RC33_RS08480	COG0070	glutamate synthase
RC33_RS08480	COG0067	glutamate synthase
RC33_RS08480	COG0069	glutamate synthase activity
RC33_RS08485	COG0493	'glutamate synthase
RC33_RS08500	COG1592	Rubrerythrin
RC33_RS08510	COG3477	response to acidic pH
RC33_RS08535	COG0840	transmembrane signaling receptor activity
RC33_RS08540	COG1858	cytochrome C peroxidase
RC33_RS08545	COG0179	Fumarylacetoacetate (FAA) hydrolase
RC33_RS08550	COG0564	pseudouridine synthase activity
RC33_RS08555	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
RC33_RS08560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
RC33_RS08585	COG0252	asparaginase activity