locus-tag	class	description
CRM97_RS00010	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRM97_RS00015	COG4605	iron ion homeostasis
CRM97_RS00020	COG4604	ABC transporter, ATP-binding protein
CRM97_RS00040	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CRM97_RS00045	COG3005	denitrification pathway
CRM97_RS00095	COG0628	permease
CRM97_RS00100	COG0114	fumarate hydratase activity
CRM97_RS00110	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CRM97_RS00120	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CRM97_RS00125	COG2252	PERMEase
CRM97_RS00135	COG2853	Lipoprotein
CRM97_RS00155	COG2814	Major facilitator Superfamily
CRM97_RS00170	COG3276	selenocysteine insertion sequence binding
CRM97_RS00200	COG0753	catalase activity
CRM97_RS00210	COG2964	Protein conserved in bacteria
CRM97_RS00215	COG0251	oxidation-reduction process
CRM97_RS00240	COG1918	ferrous iron import across plasma membrane
CRM97_RS00245	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CRM97_RS00250	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CRM97_RS00255	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CRM97_RS00260	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CRM97_RS00275	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CRM97_RS00300	COG1580	Controls the rotational direction of flagella during chemotaxis
CRM97_RS00315	COG2124	cytochrome p450
CRM97_RS00355	COG0572	uridine kinase
CRM97_RS00370	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CRM97_RS00385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRM97_RS00390	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CRM97_RS00390	COG1215	transferase activity, transferring glycosyl groups
CRM97_RS00405	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
CRM97_RS00405	COG1215	transferase activity, transferring glycosyl groups
CRM97_RS00410	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CRM97_RS00410	COG0517	IMP dehydrogenase activity
CRM97_RS00480	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CRM97_RS00505	COG3951	Flagellar rod assembly protein muramidase FlgJ
CRM97_RS00530	COG0730	response to heat
CRM97_RS00535	COG1459	type II secretion system
CRM97_RS00540	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CRM97_RS00570	COG0546	phosphoglycolate phosphatase activity
CRM97_RS00580	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CRM97_RS00585	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CRM97_RS00590	COG0210	DNA helicase
CRM97_RS00595	COG2887	Belongs to the helicase family. UvrD subfamily
CRM97_RS00640	COG0745	RESPONSE REGULATOR receiver
CRM97_RS00655	COG0505	Belongs to the CarA family
CRM97_RS00675	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CRM97_RS00690	COG0425	Belongs to the sulfur carrier protein TusA family
CRM97_RS00695	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CRM97_RS00725	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CRM97_RS00735	COG0437	4 iron, 4 sulfur cluster binding
CRM97_RS00770	COG0314	molybdopterin synthase activity
CRM97_RS00780	COG0303	'Molybdopterin
CRM97_RS00785	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CRM97_RS00805	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CRM97_RS00820	COG2992	FlgJ-related protein
CRM97_RS00830	COG0783	Belongs to the Dps family
CRM97_RS00835	COG0166	Belongs to the GPI family
CRM97_RS00845	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CRM97_RS00850	COG3839	Belongs to the ABC transporter superfamily
CRM97_RS00855	COG4662	Binding-protein-dependent transport system inner membrane component
CRM97_RS00860	COG2998	abc-type tungstate transport system, permease component
CRM97_RS00870	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CRM97_RS00875	COG1984	allophanate hydrolase subunit 2
CRM97_RS00885	COG2249	NAD(P)H dehydrogenase (quinone) activity
CRM97_RS00890	COG1733	regulation of RNA biosynthetic process
CRM97_RS00900	COG1064	alcohol dehydrogenase
CRM97_RS00940	COG2814	Major facilitator Superfamily
CRM97_RS00960	COG0640	Transcriptional regulator
CRM97_RS00970	COG0798	PFAM Bile acid sodium symporter
CRM97_RS00995	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRM97_RS01000	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CRM97_RS01010	COG0839	Belongs to the complex I subunit 6 family
CRM97_RS01045	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRM97_RS01055	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRM97_RS01070	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRM97_RS01075	COG0601	transmembrane transport
CRM97_RS01085	COG0277	FAD linked oxidase domain protein
CRM97_RS01095	COG4615	Cyclic peptide transporter
CRM97_RS01110	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CRM97_RS01115	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CRM97_RS01125	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CRM97_RS01135	COG0202	RNA polymerase activity
CRM97_RS01140	COG0203	ribosomal protein L17
CRM97_RS01180	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CRM97_RS01180	COG0140	phosphoribosyl-ATP diphosphatase activity
CRM97_RS01185	COG2171	N-acyltransferase activity
CRM97_RS01190	COG0489	protein tyrosine kinase activity
CRM97_RS01205	COG2046	Belongs to the sulfate adenylyltransferase family
CRM97_RS01210	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CRM97_RS01215	COG0268	Binds directly to 16S ribosomal RNA
CRM97_RS01225	COG0748	coenzyme F420 binding
CRM97_RS01230	COG4771	TonB-dependent receptor
CRM97_RS01235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRM97_RS01240	COG1120	ATPase activity
CRM97_RS01245	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CRM97_RS01255	COG0477	Major facilitator Superfamily
CRM97_RS01260	COG1194	a g-specific adenine glycosylase
CRM97_RS01290	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CRM97_RS01290	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CRM97_RS01300	COG1760	l-serine dehydratase
CRM97_RS01305	COG0814	amino acid
CRM97_RS01320	COG0811	peptide transport
CRM97_RS01325	COG0848	biopolymer transport protein
CRM97_RS01360	COG0328	RNA-DNA hybrid ribonuclease activity
CRM97_RS01370	COG0358	DNA primase activity
CRM97_RS01385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CRM97_RS01390	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CRM97_RS01405	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CRM97_RS01410	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CRM97_RS01415	COG1127	ABC transporter
CRM97_RS01425	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CRM97_RS01425	COG3218	ABC-type transport auxiliary lipoprotein component
CRM97_RS01435	COG0024	Methionine aminopeptidase
CRM97_RS01440	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CRM97_RS01445	COG0791	NLP P60 protein
CRM97_RS01470	COG0672	)-iron permease
CRM97_RS01495	COG1136	(ABC) transporter
CRM97_RS01545	COG1793	dna ligase
CRM97_RS01565	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CRM97_RS01570	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CRM97_RS01575	COG1987	bacterial-type flagellum assembly
CRM97_RS01590	COG1218	3'(2'),5'-bisphosphate nucleotidase
CRM97_RS01595	COG0372	Belongs to the citrate synthase family
CRM97_RS01610	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CRM97_RS01620	COG0201	protein transport
CRM97_RS01625	COG0200	Binds to the 23S rRNA
CRM97_RS01630	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CRM97_RS01635	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CRM97_RS01640	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CRM97_RS01650	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CRM97_RS01655	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CRM97_RS01660	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CRM97_RS01665	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CRM97_RS01670	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CRM97_RS01675	COG0255	Belongs to the universal ribosomal protein uL29 family
CRM97_RS01680	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CRM97_RS01685	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CRM97_RS01695	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CRM97_RS01705	COG0089	rRNA binding
CRM97_RS01715	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CRM97_RS01720	COG0051	transcription antitermination factor activity, RNA binding
CRM97_RS01725	COG1187	pseudouridine synthase activity
CRM97_RS01730	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CRM97_RS01825	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CRM97_RS01835	COG1749	Flagellar hook protein flgE
CRM97_RS01850	COG0592	DNA-directed DNA polymerase activity
CRM97_RS01855	COG0187	DNA topoisomerase II activity
CRM97_RS01870	COG2056	Na+-H+ antiporter family
CRM97_RS01875	COG0067	glutamate synthase
CRM97_RS01875	COG0069	glutamate synthase activity
CRM97_RS01875	COG0070	glutamate synthase
CRM97_RS01880	COG0493	'glutamate synthase
CRM97_RS01885	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CRM97_RS01895	COG1592	Rubrerythrin
CRM97_RS01915	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CRM97_RS01930	COG0840	transmembrane signaling receptor activity
CRM97_RS01935	COG1858	cytochrome C peroxidase
CRM97_RS01940	COG0179	Fumarylacetoacetate (FAA) hydrolase
CRM97_RS01945	COG0564	pseudouridine synthase activity
CRM97_RS01950	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CRM97_RS01955	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CRM97_RS01970	COG0504	CTP synthase activity
CRM97_RS01980	COG0252	asparaginase activity
CRM97_RS02030	COG2814	Major facilitator Superfamily
CRM97_RS02050	COG1217	gtp-binding protein TYPA
CRM97_RS02065	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CRM97_RS02095	COG0471	metal ion transport
CRM97_RS02110	COG0471	metal ion transport
CRM97_RS02120	COG1611	Belongs to the LOG family
CRM97_RS02145	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CRM97_RS02145	COG1776	CheC inhibitor of MCP methylation
CRM97_RS02150	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CRM97_RS02155	COG1191	sigma factor activity
CRM97_RS02165	COG0455	bacterial-type flagellum organization
CRM97_RS02170	COG1419	protein localization to endoplasmic reticulum
CRM97_RS02175	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CRM97_RS02180	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CRM97_RS02185	COG0402	S-adenosylhomocysteine deaminase activity
CRM97_RS02190	COG0616	signal peptide processing
CRM97_RS02210	COG1139	Iron-sulfur cluster binding protein
CRM97_RS02215	COG0247	lactate metabolic process
CRM97_RS02230	COG3021	interspecies interaction between organisms
CRM97_RS02245	COG1271	oxidase subunit
CRM97_RS02250	COG1294	oxidase, subunit
CRM97_RS02255	COG1794	racemase activity, acting on amino acids and derivatives
CRM97_RS02265	COG1027	Aspartate ammonia-lyase
CRM97_RS02270	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CRM97_RS02300	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CRM97_RS02305	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CRM97_RS02325	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CRM97_RS02325	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CRM97_RS02330	COG1192	Involved in chromosome partitioning
CRM97_RS02335	COG1475	DNA binding
CRM97_RS02350	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CRM97_RS02365	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CRM97_RS02370	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CRM97_RS02375	COG0811	peptide transport
CRM97_RS02380	COG0848	biopolymer transport protein
CRM97_RS02395	COG2885	chlorophyll binding
CRM97_RS02405	COG1047	Peptidyl-prolyl cis-trans
CRM97_RS02415	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CRM97_RS02420	COG0037	tRNA processing
CRM97_RS02445	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CRM97_RS02455	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CRM97_RS02465	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CRM97_RS02475	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CRM97_RS02500	COG0083	homoserine kinase activity
CRM97_RS02525	COG1401	restriction endodeoxyribonuclease activity
CRM97_RS02535	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CRM97_RS02540	COG1121	(ABC) transporter
CRM97_RS02560	COG0492	ferredoxin-NADP+ reductase activity
CRM97_RS02565	COG3118	belongs to the thioredoxin family
CRM97_RS02570	COG0792	nuclease activity
CRM97_RS02575	COG0460	homoserine dehydrogenase
CRM97_RS02580	COG0436	Aminotransferase
CRM97_RS02595	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CRM97_RS02600	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CRM97_RS02605	COG0254	rRNA binding
CRM97_RS02610	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CRM97_RS02630	COG0602	queuosine metabolic process
CRM97_RS02660	COG1971	Probably functions as a manganese efflux pump
CRM97_RS02675	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CRM97_RS02695	COG1840	ABC-type Fe3 transport system, periplasmic component
CRM97_RS02710	COG4206	TonB-dependent receptor
CRM97_RS02710	COG1629	transport
CRM97_RS02715	COG0811	peptide transport
CRM97_RS02720	COG0848	biopolymer transport protein
CRM97_RS02730	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CRM97_RS02735	COG1253	flavin adenine dinucleotide binding
CRM97_RS02745	COG2824	Alkylphosphonate utilization operon protein PhnA
CRM97_RS02750	COG0861	Integral membrane protein TerC family
CRM97_RS02755	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CRM97_RS02760	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CRM97_RS02760	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CRM97_RS02770	COG0606	chelatase, subunit chli
CRM97_RS02775	COG0242	peptide deformylase activity
CRM97_RS02785	COG0544	peptidyl-prolyl cis-trans isomerase activity
CRM97_RS02795	COG1157	protein secretion by the type III secretion system
CRM97_RS02800	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CRM97_RS02810	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CRM97_RS02810	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CRM97_RS02840	COG1297	OPT oligopeptide transporter protein
CRM97_RS02845	COG1968	undecaprenyl-diphosphatase activity
CRM97_RS02855	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CRM97_RS03195	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CRM97_RS03200	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CRM97_RS03215	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CRM97_RS03235	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CRM97_RS03240	COG0670	Belongs to the BI1 family
CRM97_RS03245	COG0288	reversible hydration of carbon dioxide
CRM97_RS03250	COG0668	transmembrane transport
CRM97_RS03275	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CRM97_RS03280	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CRM97_RS03305	COG0477	Major facilitator Superfamily
CRM97_RS03320	COG2921	Belongs to the UPF0250 family
CRM97_RS03330	COG0708	Exodeoxyribonuclease III
CRM97_RS03335	COG2194	sulfuric ester hydrolase activity
CRM97_RS03340	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CRM97_RS03350	COG0418	dihydroorotase activity
CRM97_RS03360	COG2226	methyltransferase
CRM97_RS03365	COG0840	transmembrane signaling receptor activity
CRM97_RS03370	COG0428	transporter
CRM97_RS03375	COG0840	transmembrane signaling receptor activity
CRM97_RS03390	COG0330	HflC and HflK could
CRM97_RS03400	COG1942	4-Oxalocrotonate Tautomerase
CRM97_RS03405	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CRM97_RS03410	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CRM97_RS03415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CRM97_RS03425	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CRM97_RS03430	COG1077	Cell shape determining protein MreB Mrl
CRM97_RS03440	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CRM97_RS03460	COG0835	chemotaxis
CRM97_RS03465	COG2198	Histidine kinase
CRM97_RS03465	COG0784	Response regulator, receiver
CRM97_RS03465	COG0643	Histidine kinase
CRM97_RS03470	COG0835	chemotaxis
CRM97_RS03470	COG0784	Response regulator, receiver
CRM97_RS03510	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CRM97_RS03530	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
CRM97_RS03550	COG4106	trans-aconitate 2-methyltransferase activity
CRM97_RS03565	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CRM97_RS03570	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CRM97_RS03575	COG2076	Multidrug Resistance protein
CRM97_RS03600	COG0019	diaminopimelate decarboxylase activity
CRM97_RS03625	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CRM97_RS03650	COG2226	methyltransferase
CRM97_RS03665	COG0251	oxidation-reduction process
CRM97_RS03680	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CRM97_RS03700	COG0450	alkyl hydroperoxide reductase
CRM97_RS03705	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CRM97_RS03710	COG1360	Flagellar Motor Protein
CRM97_RS03715	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CRM97_RS03725	COG0477	Major facilitator Superfamily
CRM97_RS03735	COG1238	metal cluster binding
CRM97_RS03755	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CRM97_RS03760	COG0730	response to heat
CRM97_RS03775	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CRM97_RS03775	COG0512	Glutamine amidotransferase of anthranilate synthase
CRM97_RS03785	COG0133	tryptophan synthase activity
CRM97_RS03800	COG1776	CheC inhibitor of MCP methylation
CRM97_RS03800	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CRM97_RS03815	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRM97_RS03820	COG0745	RESPONSE REGULATOR receiver
CRM97_RS03845	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CRM97_RS03850	COG1981	membrane
CRM97_RS03855	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CRM97_RS03865	COG1538	Outer membrane efflux protein
CRM97_RS03875	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRM97_RS03890	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CRM97_RS03905	COG0754	glutathionylspermidine amidase activity
CRM97_RS03910	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CRM97_RS03930	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CRM97_RS03935	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
CRM97_RS03940	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CRM97_RS03960	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CRM97_RS04005	COG0469	pyruvate kinase activity
CRM97_RS04010	COG0579	oxidoreductase
CRM97_RS04070	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CRM97_RS04090	COG1053	succinate dehydrogenase
CRM97_RS04095	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CRM97_RS04105	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CRM97_RS04140	COG2353	YceI-like domain
CRM97_RS04170	COG0488	(ABC) transporter
CRM97_RS04185	COG1739	Uncharacterized protein family UPF0029
CRM97_RS04245	COG1028	Short-chain dehydrogenase reductase Sdr
CRM97_RS04255	COG1053	succinate dehydrogenase
CRM97_RS04260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CRM97_RS04265	COG2048	Heterodisulfide reductase, subunit B
CRM97_RS04270	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CRM97_RS04280	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CRM97_RS04295	COG0494	nUDIX hydrolase
CRM97_RS04310	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CRM97_RS04315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CRM97_RS04345	COG2121	Domain of unknown function (DUF374)
CRM97_RS04360	COG0195	Participates in both transcription termination and antitermination
CRM97_RS04370	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CRM97_RS04375	COG0612	Peptidase, M16
CRM97_RS04380	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CRM97_RS04385	COG2346	COG2346, Truncated hemoglobins
CRM97_RS04400	COG0765	amino acid transport
CRM97_RS04430	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CRM97_RS04435	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CRM97_RS04450	COG0250	Participates in transcription elongation, termination and antitermination
CRM97_RS04455	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CRM97_RS04460	COG0081	regulation of translation
CRM97_RS04470	COG0222	ribosome binding
CRM97_RS04490	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CRM97_RS04500	COG2721	sulfolactate sulfo-lyase activity
CRM97_RS04505	COG2271	Major facilitator Superfamily
CRM97_RS04510	COG1028	Short-chain dehydrogenase reductase Sdr
CRM97_RS04515	COG0738	Major facilitator superfamily
CRM97_RS04525	COG3254	rhamnose metabolic process
CRM97_RS04530	COG1012	belongs to the aldehyde dehydrogenase family
CRM97_RS04535	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CRM97_RS04540	COG0049	tRNA binding
CRM97_RS04555	COG0582	viral genome integration into host DNA
CRM97_RS04580	COG3561	AntA/AntB antirepressor
CRM97_RS04590	COG0863	Belongs to the N(4) N(6)-methyltransferase family
CRM97_RS04840	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CRM97_RS04865	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CRM97_RS04880	COG0673	inositol 2-dehydrogenase activity
CRM97_RS04895	COG0424	maF-like protein
CRM97_RS04905	COG0542	response to heat
CRM97_RS04910	COG1937	Protein conserved in bacteria
CRM97_RS04915	COG0793	Belongs to the peptidase S41A family
CRM97_RS04925	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CRM97_RS04930	COG0047	phosphoribosylformylglycinamidine synthase activity
CRM97_RS04940	COG0204	Acyl-transferase
CRM97_RS04955	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CRM97_RS04975	COG1677	Flagellar hook-basal body complex protein FliE
CRM97_RS04980	COG1558	bacterial-type flagellum-dependent cell motility
CRM97_RS04985	COG1815	bacterial-type flagellum-dependent cell motility
CRM97_RS05005	COG0039	L-malate dehydrogenase activity
CRM97_RS05015	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CRM97_RS05025	COG0674	pyruvate-flavodoxin oxidoreductase activity
CRM97_RS05025	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CRM97_RS05030	COG1013	pyruvate-flavodoxin oxidoreductase activity
CRM97_RS05050	COG0142	geranyltranstransferase activity
CRM97_RS05070	COG0181	hydroxymethylbilane synthase activity
CRM97_RS05075	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CRM97_RS05085	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CRM97_RS05105	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CRM97_RS05135	COG1289	transmembrane transporter activity
CRM97_RS05140	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CRM97_RS05145	COG0492	ferredoxin-NADP+ reductase activity
CRM97_RS05160	COG0305	Participates in initiation and elongation during chromosome replication
CRM97_RS05205	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CRM97_RS05205	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CRM97_RS05210	COG1610	YqeY-like protein
CRM97_RS05215	COG0028	Belongs to the TPP enzyme family
CRM97_RS05220	COG0440	acetolactate synthase activity
CRM97_RS05235	COG0805	protein transport
CRM97_RS05245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CRM97_RS05250	COG0494	nUDIX hydrolase
CRM97_RS05255	COG0527	aspartate kinase activity
CRM97_RS05270	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CRM97_RS05290	COG0196	riboflavin kinase activity
CRM97_RS05295	COG2890	protein-(glutamine-N5) methyltransferase activity
CRM97_RS05310	COG2860	membrane
CRM97_RS05320	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CRM97_RS05325	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CRM97_RS05330	COG0191	fructose-bisphosphate aldolase activity
CRM97_RS05350	COG0733	neurotransmitter:sodium symporter activity
CRM97_RS05355	COG2258	MOSC domain
CRM97_RS05370	COG1473	amidohydrolase
CRM97_RS05375	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRM97_RS05385	COG1538	Outer membrane efflux protein
CRM97_RS05400	COG1696	Membrane protein involved in D-alanine export
CRM97_RS05405	COG1528	Iron-storage protein
CRM97_RS05410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CRM97_RS05415	COG0573	inorganic phosphate transmembrane transporter activity
CRM97_RS05420	COG0581	inorganic phosphate transmembrane transporter activity
CRM97_RS05435	COG0534	Mate efflux family protein
CRM97_RS05450	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CRM97_RS05460	COG0298	carbon dioxide binding
CRM97_RS05465	COG0409	Hydrogenase expression formation protein
CRM97_RS05470	COG0309	Hydrogenase expression formation protein (HypE)
CRM97_RS05475	COG0375	protein maturation
CRM97_RS05480	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CRM97_RS05485	COG3421	Type III restriction
CRM97_RS05495	COG0557	exoribonuclease II activity
CRM97_RS05530	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CRM97_RS05550	COG0497	DNA recombination
CRM97_RS05560	COG0084	hydrolase, TatD family'
CRM97_RS05565	COG1388	LysM domain
CRM97_RS05565	COG0791	NLP P60 protein
CRM97_RS05570	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CRM97_RS05660	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CRM97_RS05665	COG0802	atpase or kinase
CRM97_RS05670	COG1137	ATPase activity
CRM97_RS05675	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CRM97_RS05680	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CRM97_RS05700	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
CRM97_RS05730	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CRM97_RS05750	COG0280	phosphate acetyltransferase
CRM97_RS05780	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CRM97_RS05785	COG0849	cell division
CRM97_RS05790	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CRM97_RS05795	COG4786	Flagellar basal body rod
CRM97_RS05800	COG4786	Flagellar basal body rod
CRM97_RS05805	COG0174	glutamine synthetase
CRM97_RS05815	COG0826	peptidase U32
CRM97_RS05820	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CRM97_RS05835	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CRM97_RS05845	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CRM97_RS05845	COG1519	Transferase
CRM97_RS05850	COG0564	pseudouridine synthase activity
CRM97_RS05855	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CRM97_RS05860	COG0228	four-way junction DNA binding
CRM97_RS05865	COG1837	Belongs to the UPF0109 family
CRM97_RS05890	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CRM97_RS05895	COG1393	Belongs to the ArsC family
CRM97_RS05905	COG0587	DNA-directed DNA polymerase activity
CRM97_RS05910	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CRM97_RS05925	COG2890	protein-(glutamine-N5) methyltransferase activity
CRM97_RS05930	COG0501	Belongs to the peptidase M48B family
CRM97_RS05940	COG0521	Mo-molybdopterin cofactor biosynthetic process
CRM97_RS05965	COG1178	ABC-type Fe3 transport system permease component
CRM97_RS05975	COG3842	ATPase activity
CRM97_RS06060	COG0675	Transposase, IS605 OrfB family
CRM97_RS06070	COG4771	TonB-dependent receptor
CRM97_RS06075	COG1420	regulation of RNA biosynthetic process
CRM97_RS06100	COG0436	Aminotransferase
CRM97_RS06105	COG1045	serine acetyltransferase
CRM97_RS06110	COG1166	arginine decarboxylase activity
CRM97_RS06125	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CRM97_RS06130	COG0163	prenyltransferase activity
CRM97_RS06140	COG1464	Belongs to the NlpA lipoprotein family
CRM97_RS06145	COG1464	Belongs to the NlpA lipoprotein family
CRM97_RS06150	COG1464	Belongs to the NlpA lipoprotein family
CRM97_RS06155	COG2011	ABC-type metal ion transport system permease component
CRM97_RS06160	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CRM97_RS06175	COG0210	DNA helicase
CRM97_RS06185	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CRM97_RS06195	COG0437	4 iron, 4 sulfur cluster binding
CRM97_RS06200	COG0348	domain, Protein
CRM97_RS06205	COG3043	anaerobic respiration
CRM97_RS06240	COG0788	formyltetrahydrofolate deformylase activity
CRM97_RS06245	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CRM97_RS06255	COG0642	Histidine kinase
CRM97_RS06265	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CRM97_RS06280	COG1181	Belongs to the D-alanine--D-alanine ligase family
CRM97_RS06285	COG0632	four-way junction helicase activity
CRM97_RS06295	COG0728	peptidoglycan biosynthetic process
CRM97_RS06300	COG0215	cysteine-tRNA ligase activity
CRM97_RS06305	COG1132	(ABC) transporter
CRM97_RS06310	COG0167	dihydroorotate dehydrogenase activity
CRM97_RS06315	COG0612	Peptidase, M16
CRM97_RS06320	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CRM97_RS06325	COG1028	Short-chain dehydrogenase reductase Sdr
CRM97_RS06340	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CRM97_RS06350	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CRM97_RS06355	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CRM97_RS06370	COG1338	Plays a role in the flagellum-specific transport system
CRM97_RS06410	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CRM97_RS06430	COG1757	Na H antiporter
CRM97_RS06435	COG4221	oxidoreductase activity
CRM97_RS06445	COG1049	propionate catabolic process, 2-methylcitrate cycle
CRM97_RS06450	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CRM97_RS06460	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRM97_RS06460	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRM97_RS06500	COG1408	metallophosphoesterase
CRM97_RS06505	COG0688	phosphatidylethanolamine metabolic process
CRM97_RS06550	COG0681	Belongs to the peptidase S26 family
CRM97_RS06555	COG0303	'Molybdopterin
CRM97_RS06575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CRM97_RS06575	COG0512	Glutamine amidotransferase of anthranilate synthase
CRM97_RS06580	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CRM97_RS06585	COG0582	viral genome integration into host DNA
CRM97_RS06590	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CRM97_RS06610	COG3258	Cytochrome c
CRM97_RS06615	COG3258	Cytochrome c
CRM97_RS06645	COG2404	hydrolase activity, acting on ester bonds
CRM97_RS06650	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CRM97_RS06655	COG1959	2 iron, 2 sulfur cluster binding
CRM97_RS06660	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CRM97_RS06665	COG1196	nuclear chromosome segregation
CRM97_RS06665	COG1674	ftsk spoiiie
CRM97_RS06670	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CRM97_RS06685	COG0488	(ABC) transporter
CRM97_RS06690	COG5002	protein histidine kinase activity
CRM97_RS06695	COG0745	RESPONSE REGULATOR receiver
CRM97_RS06700	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CRM97_RS06710	COG0539	negative regulation of cytoplasmic translation
CRM97_RS06710	COG1185	polyribonucleotide nucleotidyltransferase activity
CRM97_RS06730	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CRM97_RS06735	COG0537	adenosine 5'-monophosphoramidase activity
CRM97_RS06750	COG0765	amino acid transport
CRM97_RS06760	COG1115	amino acid carrier protein
CRM97_RS06765	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CRM97_RS06795	COG1999	signal sequence binding
CRM97_RS06800	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRM97_RS06805	COG0776	regulation of translation
CRM97_RS06825	COG1966	Carbon starvation protein
CRM97_RS06830	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CRM97_RS06835	COG0765	amino acid transport
CRM97_RS06840	COG0765	amino acid transport
CRM97_RS06845	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRM97_RS06850	COG1126	abc transporter atp-binding protein
CRM97_RS06855	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CRM97_RS06860	COG2201	protein-glutamate methylesterase activity
CRM97_RS06885	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CRM97_RS06890	COG0012	GTP binding
CRM97_RS06905	COG0511	ligase activity, forming carbon-carbon bonds
CRM97_RS06905	COG5016	pyruvate
CRM97_RS06910	COG0733	neurotransmitter:sodium symporter activity
CRM97_RS06915	COG0733	neurotransmitter:sodium symporter activity
CRM97_RS06980	COG0765	amino acid transport
CRM97_RS06995	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CRM97_RS07005	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CRM97_RS07020	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CRM97_RS07040	COG0840	transmembrane signaling receptor activity
CRM97_RS07055	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CRM97_RS07075	COG0706	membrane insertase activity
CRM97_RS07090	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CRM97_RS07105	COG0824	Thioesterase
CRM97_RS07155	COG2195	Cleaves the N-terminal amino acid of tripeptides
CRM97_RS07160	COG0477	Major facilitator Superfamily
CRM97_RS07165	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRM97_RS07175	COG3022	response to hydroperoxide
CRM97_RS07180	COG1473	amidohydrolase
CRM97_RS07185	COG2807	transmembrane transport
CRM97_RS07205	COG0247	lactate metabolic process
CRM97_RS07205	COG2181	nitrate reductase activity
CRM97_RS07210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CRM97_RS07225	COG0113	porphobilinogen synthase activity
CRM97_RS07230	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CRM97_RS07245	COG2855	membrane
CRM97_RS07250	COG0583	DNA-binding transcription factor activity
CRM97_RS07255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CRM97_RS07275	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CRM97_RS07280	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CRM97_RS07320	COG0582	viral genome integration into host DNA
CRM97_RS07565	COG1333	cytochrome c biogenesis protein
CRM97_RS07565	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CRM97_RS07590	COG0683	leucine binding
CRM97_RS07615	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CRM97_RS07620	COG2204	response regulator
CRM97_RS07635	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CRM97_RS07685	COG0439	Biotin carboxylase
CRM97_RS07690	COG0772	Belongs to the SEDS family
CRM97_RS07715	COG0352	thiamine-phosphate diphosphorylase activity
CRM97_RS07720	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CRM97_RS07760	COG1193	negative regulation of DNA recombination
CRM97_RS07785	COG0517	IMP dehydrogenase activity
CRM97_RS07785	COG0516	GMP reductase activity
CRM97_RS07805	COG1058	Belongs to the CinA family
CRM97_RS07805	COG1546	Belongs to the CinA family
CRM97_RS07810	COG0456	acetyltransferase
CRM97_RS07815	COG0778	Nitroreductase
CRM97_RS07820	COG0778	Nitroreductase
CRM97_RS07825	COG0778	Nitroreductase
CRM97_RS07835	COG0750	zinc metalloprotease
CRM97_RS07840	COG2990	Protein conserved in bacteria
CRM97_RS07850	COG0629	single-stranded DNA binding
CRM97_RS07855	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CRM97_RS07860	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CRM97_RS07870	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CRM97_RS07875	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CRM97_RS07920	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CRM97_RS07930	COG0739	heme binding
CRM97_RS07935	COG0285	dihydrofolate synthase activity
CRM97_RS07955	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CRM97_RS07960	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CRM97_RS07965	COG1862	Preprotein translocase
CRM97_RS07970	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CRM97_RS07975	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CRM97_RS07980	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CRM97_RS08000	COG0210	DNA helicase
CRM97_RS08035	COG0542	response to heat
CRM97_RS08050	COG2095	MarC family integral membrane protein
CRM97_RS08055	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CRM97_RS08060	COG2833	Protein of unknown function (DUF455)
CRM97_RS08065	COG1183	phosphatidylcholine synthase activity
CRM97_RS08075	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CRM97_RS08085	COG0745	RESPONSE REGULATOR receiver
CRM97_RS08095	COG1086	Polysaccharide biosynthesis protein
CRM97_RS08100	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CRM97_RS08105	COG0110	maltose O-acetyltransferase activity
CRM97_RS08110	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CRM97_RS08115	COG0438	transferase activity, transferring glycosyl groups
CRM97_RS08125	COG0438	transferase activity, transferring glycosyl groups
CRM97_RS08130	COG1215	transferase activity, transferring glycosyl groups
CRM97_RS08135	COG0438	transferase activity, transferring glycosyl groups
CRM97_RS08140	COG1132	(ABC) transporter
CRM97_RS08145	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CRM97_RS08155	COG0859	PFAM glycosyl transferase family 9
CRM97_RS08160	COG1560	Kdo2-lipid A biosynthetic process
CRM97_RS08170	COG0463	Glycosyl transferase, family 2
CRM97_RS08175	COG1216	Glycosyl transferase, family 2
CRM97_RS08175	COG1442	glycosyl transferase family 8
CRM97_RS08180	COG1216	Glycosyl transferase, family 2
CRM97_RS08190	COG1216	Glycosyl transferase, family 2
CRM97_RS08220	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CRM97_RS08235	COG2217	Heavy metal translocating P-type atpase
CRM97_RS08240	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CRM97_RS08245	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CRM97_RS08265	COG2217	Heavy metal translocating P-type atpase
CRM97_RS08285	COG3610	response to peptide
CRM97_RS08295	COG0039	L-malate dehydrogenase activity
CRM97_RS08315	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CRM97_RS08340	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CRM97_RS08345	COG0194	GDP metabolic process
CRM97_RS08355	COG1684	flagellar biosynthetic protein fliR
CRM97_RS08370	COG0052	Belongs to the universal ribosomal protein uS2 family
CRM97_RS08375	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CRM97_RS08385	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CRM97_RS08390	COG0723	plastoquinol--plastocyanin reductase activity
CRM97_RS08395	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CRM97_RS08420	COG1301	dicarboxylic acid transport
CRM97_RS08435	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CRM97_RS08470	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CRM97_RS08480	COG0356	it plays a direct role in the translocation of protons across the membrane
CRM97_RS08485	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CRM97_RS08490	COG0552	protein localization to endoplasmic reticulum
CRM97_RS08505	COG1418	mRNA catabolic process
CRM97_RS08520	COG1295	ribonuclease BN
CRM97_RS08525	COG0277	FAD linked oxidase domain protein
CRM97_RS08535	COG0739	heme binding
CRM97_RS08545	COG1496	oxidoreductase activity
CRM97_RS08560	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CRM97_RS08570	COG0642	Histidine kinase
CRM97_RS08575	COG0745	RESPONSE REGULATOR receiver
CRM97_RS08595	COG0642	Histidine kinase
CRM97_RS08600	COG0745	RESPONSE REGULATOR receiver
CRM97_RS08605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRM97_RS08610	COG0484	heat shock protein binding
CRM97_RS08615	COG0789	Transcriptional regulator
CRM97_RS08620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CRM97_RS08620	COG0475	glutathione-regulated potassium exporter activity
CRM97_RS08630	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRM97_RS08635	COG0751	glycine-tRNA ligase activity
CRM97_RS08640	COG0739	heme binding
CRM97_RS08650	COG0248	Ppx GppA phosphatase
CRM97_RS08670	COG2814	Major facilitator Superfamily
CRM97_RS08685	COG0731	radical SAM domain protein
CRM97_RS08750	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CRM97_RS08755	COG4773	Receptor
CRM97_RS08765	COG0745	RESPONSE REGULATOR receiver
CRM97_RS08770	COG0642	Histidine kinase
CRM97_RS08780	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CRM97_RS08785	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
CRM97_RS08790	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CRM97_RS08795	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CRM97_RS08820	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CRM97_RS08825	COG1758	RNA polymerase activity
CRM97_RS08830	COG0528	UMP kinase activity
CRM97_RS08845	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CRM97_RS08860	COG0564	pseudouridine synthase activity
CRM97_RS08865	COG0772	Belongs to the SEDS family
CRM97_RS08875	COG0582	viral genome integration into host DNA
CRM97_RS08890	COG0863	Belongs to the N(4) N(6)-methyltransferase family
CRM97_RS09135	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CRM97_RS09140	COG0569	domain protein
CRM97_RS09145	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CRM97_RS09155	COG0280	phosphate acetyltransferase
CRM97_RS09155	COG0281	malic enzyme
CRM97_RS09170	COG0439	Biotin carboxylase
CRM97_RS09175	COG0511	ligase activity, forming carbon-carbon bonds
CRM97_RS09185	COG1086	Polysaccharide biosynthesis protein
CRM97_RS09190	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CRM97_RS09195	COG4310	Domain of unknown function (DUF2172)
CRM97_RS09210	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
CRM97_RS09220	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CRM97_RS09250	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CRM97_RS09280	COG1083	cytidylyl-transferase
CRM97_RS09285	COG3980	spore coat polysaccharide biosynthesis protein
CRM97_RS09290	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CRM97_RS09295	COG0107	imidazoleglycerol-phosphate synthase activity
CRM97_RS09310	COG2089	acid synthase
CRM97_RS09315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRM97_RS09320	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CRM97_RS09325	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CRM97_RS09330	COG2089	acid synthase
CRM97_RS09335	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CRM97_RS09340	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CRM97_RS09350	COG1083	cytidylyl-transferase
CRM97_RS09355	COG1028	Short-chain dehydrogenase reductase Sdr
CRM97_RS09380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CRM97_RS09385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CRM97_RS09405	COG2165	general secretion pathway protein
CRM97_RS09410	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CRM97_RS09425	COG0575	Belongs to the CDS family
CRM97_RS09435	COG1293	RNA-binding protein homologous to eukaryotic snRNP