locus-tag	class	description
CRM98_RS00015	COG0375	protein maturation
CRM98_RS00020	COG0309	Hydrogenase expression formation protein (HypE)
CRM98_RS00025	COG0409	Hydrogenase expression formation protein
CRM98_RS00030	COG0298	carbon dioxide binding
CRM98_RS00040	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CRM98_RS00055	COG0534	Mate efflux family protein
CRM98_RS00070	COG0581	inorganic phosphate transmembrane transporter activity
CRM98_RS00075	COG0573	inorganic phosphate transmembrane transporter activity
CRM98_RS00080	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CRM98_RS00085	COG1528	Iron-storage protein
CRM98_RS00090	COG1696	Membrane protein involved in D-alanine export
CRM98_RS00105	COG1538	Outer membrane efflux protein
CRM98_RS00110	COG1136	(ABC) transporter
CRM98_RS00110	COG0577	efflux transmembrane transporter activity
CRM98_RS00115	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRM98_RS00120	COG1473	amidohydrolase
CRM98_RS00135	COG2258	MOSC domain
CRM98_RS00140	COG0733	neurotransmitter:sodium symporter activity
CRM98_RS00160	COG0191	fructose-bisphosphate aldolase activity
CRM98_RS00165	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CRM98_RS00170	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CRM98_RS00180	COG2860	membrane
CRM98_RS00195	COG2890	protein-(glutamine-N5) methyltransferase activity
CRM98_RS00200	COG0196	riboflavin kinase activity
CRM98_RS00215	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CRM98_RS00220	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CRM98_RS00235	COG0527	aspartate kinase activity
CRM98_RS00240	COG0494	nUDIX hydrolase
CRM98_RS00245	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CRM98_RS00255	COG0805	protein transport
CRM98_RS00260	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CRM98_RS00270	COG0440	acetolactate synthase activity
CRM98_RS00275	COG0028	Belongs to the TPP enzyme family
CRM98_RS00280	COG1610	YqeY-like protein
CRM98_RS00285	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CRM98_RS00285	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CRM98_RS00610	COG4735	regulation of single-species biofilm formation
CRM98_RS00625	COG0305	Participates in initiation and elongation during chromosome replication
CRM98_RS00640	COG0492	ferredoxin-NADP+ reductase activity
CRM98_RS00645	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CRM98_RS00650	COG1289	transmembrane transporter activity
CRM98_RS00680	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CRM98_RS00700	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CRM98_RS00710	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CRM98_RS00715	COG0181	hydroxymethylbilane synthase activity
CRM98_RS00725	COG0442	prolyl-tRNA aminoacylation
CRM98_RS00730	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CRM98_RS00735	COG0142	geranyltranstransferase activity
CRM98_RS00755	COG1013	pyruvate-flavodoxin oxidoreductase activity
CRM98_RS00760	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CRM98_RS00760	COG0674	pyruvate-flavodoxin oxidoreductase activity
CRM98_RS00770	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
CRM98_RS00780	COG0039	L-malate dehydrogenase activity
CRM98_RS00800	COG1815	bacterial-type flagellum-dependent cell motility
CRM98_RS00805	COG1558	bacterial-type flagellum-dependent cell motility
CRM98_RS00810	COG1677	Flagellar hook-basal body complex protein FliE
CRM98_RS00840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CRM98_RS00845	COG0326	Molecular chaperone. Has ATPase activity
CRM98_RS00850	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CRM98_RS00855	COG0204	Acyl-transferase
CRM98_RS00865	COG0047	phosphoribosylformylglycinamidine synthase activity
CRM98_RS00870	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CRM98_RS00875	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CRM98_RS00880	COG0793	Belongs to the peptidase S41A family
CRM98_RS00885	COG1937	Protein conserved in bacteria
CRM98_RS00890	COG0542	response to heat
CRM98_RS00900	COG0424	maF-like protein
CRM98_RS00905	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CRM98_RS00915	COG0673	inositol 2-dehydrogenase activity
CRM98_RS00920	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CRM98_RS00930	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
CRM98_RS00975	COG0049	tRNA binding
CRM98_RS00980	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CRM98_RS00990	COG3254	rhamnose metabolic process
CRM98_RS01000	COG0738	Major facilitator superfamily
CRM98_RS01005	COG1028	Short-chain dehydrogenase reductase Sdr
CRM98_RS01015	COG2721	sulfolactate sulfo-lyase activity
CRM98_RS01025	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CRM98_RS01035	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CRM98_RS01040	COG0085	RNA polymerase activity
CRM98_RS01045	COG0222	ribosome binding
CRM98_RS01050	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CRM98_RS01055	COG0081	regulation of translation
CRM98_RS01060	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CRM98_RS01065	COG0250	Participates in transcription elongation, termination and antitermination
CRM98_RS01080	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CRM98_RS01085	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CRM98_RS01115	COG0765	amino acid transport
CRM98_RS01130	COG2346	COG2346, Truncated hemoglobins
CRM98_RS01135	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CRM98_RS01140	COG0612	Peptidase, M16
CRM98_RS01145	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CRM98_RS01155	COG0195	Participates in both transcription termination and antitermination
CRM98_RS01165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CRM98_RS01170	COG2121	Domain of unknown function (DUF374)
CRM98_RS01190	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CRM98_RS01200	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CRM98_RS01205	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CRM98_RS01225	COG4771	TonB-dependent receptor
CRM98_RS01235	COG4771	TonB-dependent receptor
CRM98_RS01240	COG0825	malonyl-CoA metabolic process
CRM98_RS01245	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CRM98_RS01250	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CRM98_RS01255	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CRM98_RS01260	COG2048	Heterodisulfide reductase, subunit B
CRM98_RS01265	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CRM98_RS01270	COG1053	succinate dehydrogenase
CRM98_RS01280	COG1028	Short-chain dehydrogenase reductase Sdr
CRM98_RS01290	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CRM98_RS01295	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CRM98_RS01300	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CRM98_RS01340	COG1739	Uncharacterized protein family UPF0029
CRM98_RS01355	COG0488	(ABC) transporter
CRM98_RS01385	COG2353	YceI-like domain
CRM98_RS01435	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CRM98_RS01440	COG1053	succinate dehydrogenase
CRM98_RS01460	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CRM98_RS01475	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CRM98_RS01480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CRM98_RS01515	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CRM98_RS01520	COG0579	oxidoreductase
CRM98_RS01525	COG0469	pyruvate kinase activity
CRM98_RS01540	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CRM98_RS01570	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CRM98_RS01580	COG0284	orotidine-5'-phosphate decarboxylase activity
CRM98_RS01590	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
CRM98_RS01600	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CRM98_RS01615	COG1666	GTP binding
CRM98_RS01620	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CRM98_RS01625	COG0754	glutathionylspermidine amidase activity
CRM98_RS01640	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CRM98_RS01655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CRM98_RS01665	COG1538	Outer membrane efflux protein
CRM98_RS01675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CRM98_RS01680	COG1981	membrane
CRM98_RS01685	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CRM98_RS01700	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CRM98_RS01710	COG0745	RESPONSE REGULATOR receiver
CRM98_RS01715	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
CRM98_RS01730	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CRM98_RS01730	COG1776	CheC inhibitor of MCP methylation
CRM98_RS01745	COG0133	tryptophan synthase activity
CRM98_RS01770	COG0730	response to heat
CRM98_RS01775	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CRM98_RS01780	COG1238	metal cluster binding
CRM98_RS01790	COG0477	Major facilitator Superfamily
CRM98_RS01800	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CRM98_RS01805	COG1360	Flagellar Motor Protein
CRM98_RS01810	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CRM98_RS01815	COG0450	alkyl hydroperoxide reductase
CRM98_RS01825	COG0105	UTP biosynthetic process
CRM98_RS01835	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CRM98_RS01840	COG0416	fatty acid biosynthetic process
CRM98_RS01845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CRM98_RS01850	COG0251	oxidation-reduction process
CRM98_RS01855	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CRM98_RS01860	COG1570	exodeoxyribonuclease VII activity
CRM98_RS01865	COG2226	methyltransferase
CRM98_RS01880	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CRM98_RS01890	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CRM98_RS01900	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CRM98_RS01915	COG0019	diaminopimelate decarboxylase activity
CRM98_RS01940	COG2076	Multidrug Resistance protein
CRM98_RS01945	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
CRM98_RS01950	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CRM98_RS01960	COG2830	Protein of unknown function (DUF452)
CRM98_RS01965	COG4106	trans-aconitate 2-methyltransferase activity
CRM98_RS02010	COG0454	-acetyltransferase
CRM98_RS02045	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CRM98_RS02065	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CRM98_RS02075	COG0835	chemotaxis
CRM98_RS02075	COG0784	Response regulator, receiver
CRM98_RS02080	COG2198	Histidine kinase
CRM98_RS02080	COG0643	Histidine kinase
CRM98_RS02080	COG0784	Response regulator, receiver
CRM98_RS02085	COG0835	chemotaxis
CRM98_RS02105	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CRM98_RS02115	COG1077	Cell shape determining protein MreB Mrl
CRM98_RS02120	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CRM98_RS02125	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CRM98_RS02135	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CRM98_RS02140	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CRM98_RS02145	COG1942	4-Oxalocrotonate Tautomerase
CRM98_RS02155	COG0330	HflC and HflK could
CRM98_RS02175	COG0243	molybdopterin cofactor binding
CRM98_RS02180	COG0428	transporter
CRM98_RS02185	COG0840	transmembrane signaling receptor activity
CRM98_RS02190	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CRM98_RS02200	COG0418	dihydroorotase activity
CRM98_RS02210	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CRM98_RS02215	COG2194	sulfuric ester hydrolase activity
CRM98_RS02220	COG0708	Exodeoxyribonuclease III
CRM98_RS02230	COG2921	Belongs to the UPF0250 family
CRM98_RS02235	COG0315	cyclic pyranopterin monophosphate synthase activity
CRM98_RS02245	COG0477	Major facilitator Superfamily
CRM98_RS02265	COG3290	protein histidine kinase activity
CRM98_RS02265	COG0840	transmembrane signaling receptor activity
CRM98_RS02270	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CRM98_RS02275	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CRM98_RS02300	COG0668	transmembrane transport
CRM98_RS02305	COG0288	reversible hydration of carbon dioxide
CRM98_RS02310	COG0670	Belongs to the BI1 family
CRM98_RS02315	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CRM98_RS02320	COG0233	cytoplasmic translational termination
CRM98_RS02325	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CRM98_RS02335	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CRM98_RS02345	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CRM98_RS02350	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
CRM98_RS02355	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CRM98_RS02360	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CRM98_RS02370	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CRM98_RS02420	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CRM98_RS02425	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CRM98_RS02430	COG1968	undecaprenyl-diphosphatase activity
CRM98_RS02435	COG1297	OPT oligopeptide transporter protein
CRM98_RS02440	COG2851	Citrate transporter
CRM98_RS02465	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CRM98_RS02465	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CRM98_RS02470	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CRM98_RS02475	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CRM98_RS02480	COG1157	protein secretion by the type III secretion system
CRM98_RS02485	COG0302	gtp cyclohydrolase
CRM98_RS02490	COG0544	peptidyl-prolyl cis-trans isomerase activity
CRM98_RS02500	COG0242	peptide deformylase activity
CRM98_RS02505	COG0606	chelatase, subunit chli
CRM98_RS02515	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CRM98_RS02515	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CRM98_RS02520	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CRM98_RS02525	COG0861	Integral membrane protein TerC family
CRM98_RS02530	COG2824	Alkylphosphonate utilization operon protein PhnA
CRM98_RS02540	COG1253	flavin adenine dinucleotide binding
CRM98_RS02545	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CRM98_RS02555	COG0848	biopolymer transport protein
CRM98_RS02560	COG0811	peptide transport
CRM98_RS02565	COG1629	transport
CRM98_RS02565	COG4206	TonB-dependent receptor
CRM98_RS02580	COG1840	ABC-type Fe3 transport system, periplasmic component
CRM98_RS02610	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CRM98_RS02625	COG1971	Probably functions as a manganese efflux pump
CRM98_RS02650	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CRM98_RS02655	COG0602	queuosine metabolic process
CRM98_RS02675	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CRM98_RS02680	COG0254	rRNA binding
CRM98_RS02685	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CRM98_RS02690	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CRM98_RS02705	COG0436	Aminotransferase
CRM98_RS02710	COG0460	homoserine dehydrogenase
CRM98_RS02715	COG0792	nuclease activity
CRM98_RS02720	COG3118	belongs to the thioredoxin family
CRM98_RS02725	COG0492	ferredoxin-NADP+ reductase activity
CRM98_RS02735	COG0840	transmembrane signaling receptor activity
CRM98_RS02745	COG1121	(ABC) transporter
CRM98_RS02750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CRM98_RS02775	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CRM98_RS02785	COG0083	homoserine kinase activity
CRM98_RS02795	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CRM98_RS02810	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CRM98_RS02820	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CRM98_RS02825	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CRM98_RS02830	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CRM98_RS02840	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CRM98_RS02865	COG0037	tRNA processing
CRM98_RS02870	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CRM98_RS02875	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CRM98_RS02880	COG1047	Peptidyl-prolyl cis-trans
CRM98_RS02890	COG2885	chlorophyll binding
CRM98_RS02905	COG0848	biopolymer transport protein
CRM98_RS02910	COG0811	peptide transport
CRM98_RS02915	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CRM98_RS02920	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CRM98_RS02925	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CRM98_RS02935	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CRM98_RS02940	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CRM98_RS02950	COG1475	DNA binding
CRM98_RS02955	COG1192	Involved in chromosome partitioning
CRM98_RS02960	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CRM98_RS02960	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CRM98_RS02965	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CRM98_RS02975	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CRM98_RS02980	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CRM98_RS02985	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CRM98_RS03015	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CRM98_RS03020	COG1027	Aspartate ammonia-lyase
CRM98_RS03025	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CRM98_RS03030	COG1794	racemase activity, acting on amino acids and derivatives
CRM98_RS03035	COG1294	oxidase, subunit
CRM98_RS03040	COG1271	oxidase subunit
CRM98_RS03055	COG3021	interspecies interaction between organisms
CRM98_RS03070	COG0247	lactate metabolic process
CRM98_RS03075	COG1139	Iron-sulfur cluster binding protein
CRM98_RS03095	COG0616	signal peptide processing
CRM98_RS03100	COG0402	S-adenosylhomocysteine deaminase activity
CRM98_RS03105	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CRM98_RS03110	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CRM98_RS03115	COG1419	protein localization to endoplasmic reticulum
CRM98_RS03120	COG0455	bacterial-type flagellum organization
CRM98_RS03130	COG1191	sigma factor activity
CRM98_RS03135	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CRM98_RS03140	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CRM98_RS03140	COG1776	CheC inhibitor of MCP methylation
CRM98_RS03175	COG0471	metal ion transport
CRM98_RS03180	COG0471	metal ion transport
CRM98_RS03190	COG0471	metal ion transport
CRM98_RS03220	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CRM98_RS03235	COG1217	gtp-binding protein TYPA
CRM98_RS03255	COG2814	Major facilitator Superfamily
CRM98_RS03310	COG0252	asparaginase activity
CRM98_RS03320	COG0504	CTP synthase activity
CRM98_RS03330	COG1823	symporter activity
CRM98_RS03335	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CRM98_RS03340	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CRM98_RS03345	COG0564	pseudouridine synthase activity
CRM98_RS03350	COG0179	Fumarylacetoacetate (FAA) hydrolase
CRM98_RS03355	COG1858	cytochrome C peroxidase
CRM98_RS03360	COG0840	transmembrane signaling receptor activity
CRM98_RS03375	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CRM98_RS03385	COG3477	response to acidic pH
CRM98_RS03390	COG0129	dihydroxy-acid dehydratase activity
CRM98_RS03395	COG1592	Rubrerythrin
CRM98_RS03405	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CRM98_RS03410	COG0493	'glutamate synthase
CRM98_RS03420	COG0070	glutamate synthase
CRM98_RS03420	COG0069	glutamate synthase activity
CRM98_RS03420	COG0067	glutamate synthase
CRM98_RS03425	COG2056	Na+-H+ antiporter family
CRM98_RS03440	COG0187	DNA topoisomerase II activity
CRM98_RS03445	COG0592	DNA-directed DNA polymerase activity
CRM98_RS03450	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CRM98_RS03455	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CRM98_RS03460	COG1749	Flagellar hook protein flgE
CRM98_RS03470	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CRM98_RS03480	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CRM98_RS03500	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CRM98_RS03505	COG0473	3-isopropylmalate dehydrogenase activity
CRM98_RS03510	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CRM98_RS03550	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CRM98_RS03560	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CRM98_RS03565	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CRM98_RS03570	COG1187	pseudouridine synthase activity
CRM98_RS03575	COG0051	transcription antitermination factor activity, RNA binding
CRM98_RS03580	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CRM98_RS03585	COG0088	Forms part of the polypeptide exit tunnel
CRM98_RS03590	COG0089	rRNA binding
CRM98_RS03600	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CRM98_RS03610	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CRM98_RS03615	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CRM98_RS03620	COG0255	Belongs to the universal ribosomal protein uL29 family
CRM98_RS03625	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CRM98_RS03630	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CRM98_RS03635	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CRM98_RS03640	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CRM98_RS03645	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CRM98_RS03650	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CRM98_RS03655	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CRM98_RS03660	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CRM98_RS03665	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CRM98_RS03670	COG0200	Binds to the 23S rRNA
CRM98_RS03675	COG0201	protein transport
CRM98_RS03685	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CRM98_RS03690	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CRM98_RS03700	COG0372	Belongs to the citrate synthase family
CRM98_RS03705	COG1218	3'(2'),5'-bisphosphate nucleotidase
CRM98_RS03725	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CRM98_RS03730	COG1987	bacterial-type flagellum assembly
CRM98_RS03735	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CRM98_RS03740	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CRM98_RS03745	COG0148	phosphopyruvate hydratase activity
CRM98_RS03760	COG1793	dna ligase
CRM98_RS03810	COG1136	(ABC) transporter
CRM98_RS03835	COG0672	)-iron permease
CRM98_RS03850	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CRM98_RS03855	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CRM98_RS03860	COG0791	NLP P60 protein
CRM98_RS03865	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CRM98_RS03870	COG0024	Methionine aminopeptidase
CRM98_RS03880	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
CRM98_RS03880	COG3218	ABC-type transport auxiliary lipoprotein component
CRM98_RS03890	COG1127	ABC transporter
CRM98_RS03895	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CRM98_RS03900	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CRM98_RS03915	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CRM98_RS03920	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CRM98_RS03935	COG0358	DNA primase activity
CRM98_RS03945	COG0328	RNA-DNA hybrid ribonuclease activity
CRM98_RS03950	COG0571	ribonuclease III activity
CRM98_RS03955	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CRM98_RS03980	COG0848	biopolymer transport protein
CRM98_RS03985	COG0811	peptide transport
CRM98_RS04000	COG0814	amino acid
CRM98_RS04005	COG1760	l-serine dehydratase
CRM98_RS04015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CRM98_RS04015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CRM98_RS04045	COG1194	a g-specific adenine glycosylase
CRM98_RS04050	COG0477	Major facilitator Superfamily
CRM98_RS04060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CRM98_RS04065	COG1120	ATPase activity
CRM98_RS04070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRM98_RS04075	COG4771	TonB-dependent receptor
CRM98_RS04080	COG0748	coenzyme F420 binding
CRM98_RS04085	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CRM98_RS04090	COG0268	Binds directly to 16S ribosomal RNA
CRM98_RS04095	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CRM98_RS04100	COG2046	Belongs to the sulfate adenylyltransferase family
CRM98_RS04110	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CRM98_RS04110	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CRM98_RS04115	COG0489	protein tyrosine kinase activity
CRM98_RS04120	COG2171	N-acyltransferase activity
CRM98_RS04125	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CRM98_RS04125	COG0140	phosphoribosyl-ATP diphosphatase activity
CRM98_RS04140	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CRM98_RS04150	COG0131	Imidazoleglycerol-phosphate dehydratase
CRM98_RS04150	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CRM98_RS04155	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CRM98_RS04165	COG0203	ribosomal protein L17
CRM98_RS04170	COG0202	RNA polymerase activity
CRM98_RS04175	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CRM98_RS04180	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CRM98_RS04190	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CRM98_RS04195	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CRM98_RS04200	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CRM98_RS04210	COG4615	Cyclic peptide transporter
CRM98_RS04220	COG0277	FAD linked oxidase domain protein
CRM98_RS04230	COG0601	transmembrane transport
CRM98_RS04235	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CRM98_RS04245	COG4608	Belongs to the ABC transporter superfamily
CRM98_RS04250	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRM98_RS04255	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRM98_RS04260	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRM98_RS04285	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CRM98_RS04290	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRM98_RS04295	COG0839	Belongs to the complex I subunit 6 family
CRM98_RS04305	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CRM98_RS04310	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CRM98_RS04345	COG1733	regulation of RNA biosynthetic process
CRM98_RS04350	COG2910	NAD(P)H-binding
CRM98_RS04360	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CRM98_RS04380	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CRM98_RS04385	COG1064	alcohol dehydrogenase
CRM98_RS04395	COG1733	regulation of RNA biosynthetic process
CRM98_RS04400	COG2249	NAD(P)H dehydrogenase (quinone) activity
CRM98_RS04410	COG1984	allophanate hydrolase subunit 2
CRM98_RS04415	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CRM98_RS04420	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CRM98_RS04425	COG2998	abc-type tungstate transport system, permease component
CRM98_RS04430	COG4662	Binding-protein-dependent transport system inner membrane component
CRM98_RS04435	COG3839	Belongs to the ABC transporter superfamily
CRM98_RS04440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
CRM98_RS04450	COG0166	Belongs to the GPI family
CRM98_RS04455	COG0783	Belongs to the Dps family
CRM98_RS04465	COG2992	FlgJ-related protein
CRM98_RS04470	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CRM98_RS04475	COG0237	dephospho-CoA kinase activity
CRM98_RS04480	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CRM98_RS04495	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
CRM98_RS04505	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CRM98_RS04510	COG0303	'Molybdopterin
CRM98_RS04515	COG0314	molybdopterin synthase activity
CRM98_RS04545	COG3383	formate dehydrogenase (NAD+) activity
CRM98_RS04555	COG0437	4 iron, 4 sulfur cluster binding
CRM98_RS04565	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
CRM98_RS04595	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CRM98_RS04600	COG0425	Belongs to the sulfur carrier protein TusA family
CRM98_RS04615	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CRM98_RS04635	COG0505	Belongs to the CarA family
CRM98_RS04650	COG0745	RESPONSE REGULATOR receiver
CRM98_RS04695	COG2887	Belongs to the helicase family. UvrD subfamily
CRM98_RS04700	COG0210	DNA helicase
CRM98_RS04705	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CRM98_RS04710	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CRM98_RS04720	COG0546	phosphoglycolate phosphatase activity
CRM98_RS04750	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CRM98_RS04755	COG1459	type II secretion system
CRM98_RS04760	COG0730	response to heat
CRM98_RS04785	COG3951	Flagellar rod assembly protein muramidase FlgJ
CRM98_RS04790	COG1706	bacterial-type flagellum-dependent cell motility
CRM98_RS04810	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CRM98_RS04815	COG0585	pseudouridine synthase activity
CRM98_RS04825	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CRM98_RS04830	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CRM98_RS04835	COG0037	tRNA processing
CRM98_RS04880	COG0517	IMP dehydrogenase activity
CRM98_RS04880	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CRM98_RS04895	COG1216	Glycosyl transferase, family 2
CRM98_RS04895	COG1442	glycosyl transferase family 8
CRM98_RS04900	COG0562	UDP-galactopyranose mutase
CRM98_RS04905	COG1216	Glycosyl transferase, family 2
CRM98_RS04925	COG1216	Glycosyl transferase, family 2
CRM98_RS04955	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRM98_RS04975	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CRM98_RS05000	COG2226	methyltransferase
CRM98_RS05005	COG3848	Pyruvate phosphate dikinase
CRM98_RS05005	COG0574	Belongs to the PEP-utilizing enzyme family
CRM98_RS05010	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CRM98_RS05015	COG1213	nucleotidyl transferase
CRM98_RS05020	COG0529	Catalyzes the synthesis of activated sulfate
CRM98_RS05040	COG2124	cytochrome p450
CRM98_RS05050	COG0736	holo-[acyl-carrier-protein] synthase activity
CRM98_RS05055	COG1580	Controls the rotational direction of flagella during chemotaxis
CRM98_RS05075	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CRM98_RS05080	COG0126	phosphoglycerate kinase activity
CRM98_RS05085	COG0149	triose-phosphate isomerase activity
CRM98_RS05090	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CRM98_RS05095	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CRM98_RS05105	COG1918	ferrous iron import across plasma membrane
CRM98_RS05130	COG0251	oxidation-reduction process
CRM98_RS05135	COG2964	Protein conserved in bacteria
CRM98_RS05145	COG0753	catalase activity
CRM98_RS05160	COG0716	FMN binding
CRM98_RS05175	COG3276	selenocysteine insertion sequence binding
CRM98_RS05180	COG1921	L-seryl-tRNASec selenium transferase activity
CRM98_RS05195	COG2814	Major facilitator Superfamily
CRM98_RS05200	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CRM98_RS05215	COG2853	Lipoprotein
CRM98_RS05225	COG2252	PERMEase
CRM98_RS05230	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CRM98_RS05240	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CRM98_RS05250	COG0114	fumarate hydratase activity
CRM98_RS05255	COG0628	permease
CRM98_RS05260	COG2255	four-way junction helicase activity
CRM98_RS05275	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CRM98_RS05280	COG3005	denitrification pathway
CRM98_RS05285	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CRM98_RS05300	COG4607	ABC-type enterochelin transport system periplasmic component
CRM98_RS05305	COG4604	ABC transporter, ATP-binding protein
CRM98_RS05310	COG4605	iron ion homeostasis
CRM98_RS05315	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CRM98_RS05320	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
CRM98_RS05330	COG1293	RNA-binding protein homologous to eukaryotic snRNP
CRM98_RS05340	COG0575	Belongs to the CDS family
CRM98_RS05345	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CRM98_RS05355	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CRM98_RS05360	COG2165	general secretion pathway protein
CRM98_RS05380	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CRM98_RS05385	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CRM98_RS05410	COG1028	Short-chain dehydrogenase reductase Sdr
CRM98_RS05415	COG1083	cytidylyl-transferase
CRM98_RS05425	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CRM98_RS05430	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CRM98_RS05435	COG2089	acid synthase
CRM98_RS05470	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CRM98_RS05475	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CRM98_RS05485	COG2089	acid synthase
CRM98_RS05500	COG0107	imidazoleglycerol-phosphate synthase activity
CRM98_RS05505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CRM98_RS05510	COG3980	spore coat polysaccharide biosynthesis protein
CRM98_RS05515	COG1083	cytidylyl-transferase
CRM98_RS05560	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CRM98_RS05595	COG4310	Domain of unknown function (DUF2172)
CRM98_RS05600	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CRM98_RS05605	COG1086	Polysaccharide biosynthesis protein
CRM98_RS05615	COG0511	ligase activity, forming carbon-carbon bonds
CRM98_RS05620	COG0439	Biotin carboxylase
CRM98_RS05635	COG0281	malic enzyme
CRM98_RS05635	COG0280	phosphate acetyltransferase
CRM98_RS05640	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CRM98_RS05645	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CRM98_RS05650	COG0569	domain protein
CRM98_RS05655	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CRM98_RS05670	COG0772	Belongs to the SEDS family
CRM98_RS05675	COG0564	pseudouridine synthase activity
CRM98_RS05685	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CRM98_RS05690	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CRM98_RS05705	COG0528	UMP kinase activity
CRM98_RS05710	COG1758	RNA polymerase activity
CRM98_RS05715	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CRM98_RS05720	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CRM98_RS05735	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CRM98_RS05735	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CRM98_RS05740	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CRM98_RS05745	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CRM98_RS05750	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
CRM98_RS05755	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CRM98_RS05760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CRM98_RS05765	COG0642	Histidine kinase
CRM98_RS05770	COG0745	RESPONSE REGULATOR receiver
CRM98_RS05775	COG0484	heat shock protein binding
CRM98_RS05780	COG4773	Receptor
CRM98_RS05785	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CRM98_RS05800	COG1942	4-Oxalocrotonate Tautomerase
CRM98_RS05810	COG1185	polyribonucleotide nucleotidyltransferase activity
CRM98_RS05835	COG0518	GMP synthase (glutamine-hydrolyzing) activity
CRM98_RS05835	COG0519	Catalyzes the synthesis of GMP from XMP
CRM98_RS05845	COG0322	excinuclease ABC activity
CRM98_RS05855	COG0731	radical SAM domain protein
CRM98_RS05860	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CRM98_RS05870	COG2814	Major facilitator Superfamily
CRM98_RS05880	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CRM98_RS05885	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CRM98_RS05890	COG0248	Ppx GppA phosphatase
CRM98_RS05900	COG0739	heme binding
CRM98_RS05905	COG0751	glycine-tRNA ligase activity
CRM98_RS05910	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CRM98_RS05920	COG0475	glutathione-regulated potassium exporter activity
CRM98_RS05920	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CRM98_RS05925	COG0789	Transcriptional regulator
CRM98_RS05930	COG0484	heat shock protein binding
CRM98_RS05935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CRM98_RS05940	COG0745	RESPONSE REGULATOR receiver
CRM98_RS05945	COG0642	Histidine kinase
CRM98_RS05965	COG0745	RESPONSE REGULATOR receiver
CRM98_RS05970	COG0642	Histidine kinase
CRM98_RS05975	COG0459	protein refolding
CRM98_RS05980	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CRM98_RS05995	COG1496	oxidoreductase activity
CRM98_RS06005	COG0739	heme binding
CRM98_RS06015	COG0277	FAD linked oxidase domain protein
CRM98_RS06020	COG1295	ribonuclease BN
CRM98_RS06050	COG0552	protein localization to endoplasmic reticulum
CRM98_RS06055	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CRM98_RS06060	COG0356	it plays a direct role in the translocation of protons across the membrane
CRM98_RS06070	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CRM98_RS06105	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CRM98_RS06120	COG1301	dicarboxylic acid transport
CRM98_RS06140	COG0445	tRNA wobble uridine modification
CRM98_RS06145	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
CRM98_RS06150	COG0723	plastoquinol--plastocyanin reductase activity
CRM98_RS06155	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CRM98_RS06165	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CRM98_RS06170	COG0052	Belongs to the universal ribosomal protein uS2 family
CRM98_RS06175	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CRM98_RS06185	COG1684	flagellar biosynthetic protein fliR
CRM98_RS06195	COG0194	GDP metabolic process
CRM98_RS06200	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CRM98_RS06205	COG0018	arginyl-trna synthetase
CRM98_RS06220	COG0217	transcriptional regulatory protein
CRM98_RS06225	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CRM98_RS06240	COG0586	Pfam SNARE associated Golgi protein
CRM98_RS06245	COG0039	L-malate dehydrogenase activity
CRM98_RS06255	COG3610	response to peptide
CRM98_RS06275	COG2217	Heavy metal translocating P-type atpase
CRM98_RS06295	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CRM98_RS06300	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CRM98_RS06305	COG2217	Heavy metal translocating P-type atpase
CRM98_RS06320	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CRM98_RS06345	COG1216	Glycosyl transferase, family 2
CRM98_RS06365	COG2089	acid synthase
CRM98_RS06375	COG1442	glycosyl transferase family 8
CRM98_RS06375	COG1216	Glycosyl transferase, family 2
CRM98_RS06385	COG1442	glycosyl transferase family 8
CRM98_RS06385	COG1216	Glycosyl transferase, family 2
CRM98_RS06395	COG1560	Kdo2-lipid A biosynthetic process
CRM98_RS06400	COG0859	PFAM glycosyl transferase family 9
CRM98_RS06410	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CRM98_RS06415	COG1132	(ABC) transporter
CRM98_RS06420	COG0438	transferase activity, transferring glycosyl groups
CRM98_RS06425	COG1215	transferase activity, transferring glycosyl groups
CRM98_RS06430	COG0438	transferase activity, transferring glycosyl groups
CRM98_RS06435	COG1287	oligosaccharyl transferase activity
CRM98_RS06440	COG0438	transferase activity, transferring glycosyl groups
CRM98_RS06445	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CRM98_RS06450	COG0110	maltose O-acetyltransferase activity
CRM98_RS06460	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CRM98_RS06465	COG1086	Polysaccharide biosynthesis protein
CRM98_RS06475	COG0745	RESPONSE REGULATOR receiver
CRM98_RS06480	COG2264	protein methyltransferase activity
CRM98_RS06485	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CRM98_RS06495	COG1183	phosphatidylcholine synthase activity
CRM98_RS06500	COG2833	Protein of unknown function (DUF455)
CRM98_RS06505	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CRM98_RS06510	COG2095	MarC family integral membrane protein
CRM98_RS06520	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CRM98_RS06525	COG0542	response to heat
CRM98_RS06540	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CRM98_RS06560	COG0210	DNA helicase
CRM98_RS06575	COG0540	Belongs to the ATCase OTCase family
CRM98_RS06580	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CRM98_RS06585	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CRM98_RS06590	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CRM98_RS06595	COG1862	Preprotein translocase
CRM98_RS06600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CRM98_RS06605	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CRM98_RS06610	COG0495	leucyl-tRNA aminoacylation
CRM98_RS06625	COG0285	dihydrofolate synthase activity
CRM98_RS06630	COG0739	heme binding
CRM98_RS06640	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CRM98_RS06685	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CRM98_RS06690	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CRM98_RS06700	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CRM98_RS06705	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CRM98_RS06710	COG0629	single-stranded DNA binding
CRM98_RS06720	COG2990	Protein conserved in bacteria
CRM98_RS06725	COG0750	zinc metalloprotease
CRM98_RS06735	COG0778	Nitroreductase
CRM98_RS06740	COG0778	Nitroreductase
CRM98_RS06745	COG0456	acetyltransferase
CRM98_RS06750	COG1546	Belongs to the CinA family
CRM98_RS06750	COG1058	Belongs to the CinA family
CRM98_RS06770	COG0517	IMP dehydrogenase activity
CRM98_RS06770	COG0516	GMP reductase activity
CRM98_RS06800	COG1193	negative regulation of DNA recombination
CRM98_RS06820	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CRM98_RS06855	COG2022	thiamine diphosphate biosynthetic process
CRM98_RS06860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CRM98_RS06865	COG0352	thiamine-phosphate diphosphorylase activity
CRM98_RS06885	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CRM98_RS06890	COG0772	Belongs to the SEDS family
CRM98_RS06895	COG0439	Biotin carboxylase
CRM98_RS06905	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
CRM98_RS06930	COG0481	GTPase activity
CRM98_RS06945	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CRM98_RS06960	COG2204	response regulator
CRM98_RS06965	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CRM98_RS07015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CRM98_RS07015	COG1333	cytochrome c biogenesis protein
CRM98_RS07035	COG0343	queuine tRNA-ribosyltransferase activity
CRM98_RS07055	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CRM98_RS07060	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CRM98_RS07080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CRM98_RS07085	COG0583	DNA-binding transcription factor activity
CRM98_RS07090	COG2855	membrane
CRM98_RS07100	COG0357	Ribosomal RNA small subunit methyltransferase G
CRM98_RS07105	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CRM98_RS07110	COG0113	porphobilinogen synthase activity
CRM98_RS07115	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CRM98_RS07125	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CRM98_RS07130	COG0247	lactate metabolic process
CRM98_RS07130	COG2181	nitrate reductase activity
CRM98_RS07150	COG2807	transmembrane transport
CRM98_RS07160	COG1473	amidohydrolase
CRM98_RS07165	COG3022	response to hydroperoxide
CRM98_RS07175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRM98_RS07180	COG0477	Major facilitator Superfamily
CRM98_RS07185	COG2195	Cleaves the N-terminal amino acid of tripeptides
CRM98_RS07205	COG0500	methyltransferase
CRM98_RS07240	COG0824	Thioesterase
CRM98_RS07260	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CRM98_RS07270	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CRM98_RS07275	COG0706	membrane insertase activity
CRM98_RS07285	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CRM98_RS07290	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CRM98_RS07295	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
CRM98_RS07300	COG0138	bifunctional purine biosynthesis protein purh
CRM98_RS07310	COG0840	transmembrane signaling receptor activity
CRM98_RS07325	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CRM98_RS07340	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CRM98_RS07350	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CRM98_RS07355	COG0653	protein targeting
CRM98_RS07365	COG0765	amino acid transport
CRM98_RS07425	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CRM98_RS07430	COG0733	neurotransmitter:sodium symporter activity
CRM98_RS07435	COG0733	neurotransmitter:sodium symporter activity
CRM98_RS07440	COG5016	pyruvate
CRM98_RS07440	COG0511	ligase activity, forming carbon-carbon bonds
CRM98_RS07445	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CRM98_RS07450	COG0165	Argininosuccinate lyase
CRM98_RS07455	COG0012	GTP binding
CRM98_RS07460	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CRM98_RS07470	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CRM98_RS07485	COG2201	protein-glutamate methylesterase activity
CRM98_RS07490	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CRM98_RS07495	COG1126	abc transporter atp-binding protein
CRM98_RS07500	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRM98_RS07505	COG0765	amino acid transport
CRM98_RS07510	COG0765	amino acid transport
CRM98_RS07515	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CRM98_RS07520	COG1966	Carbon starvation protein
CRM98_RS07540	COG0776	regulation of translation
CRM98_RS07545	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CRM98_RS07550	COG1999	signal sequence binding
CRM98_RS07575	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CRM98_RS07580	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CRM98_RS07585	COG1115	amino acid carrier protein
CRM98_RS07595	COG0765	amino acid transport
CRM98_RS07610	COG0537	adenosine 5'-monophosphoramidase activity
CRM98_RS07615	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CRM98_RS07620	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRM98_RS07620	COG0072	phenylalanine-tRNA ligase activity
CRM98_RS07625	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CRM98_RS07630	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CRM98_RS07635	COG1185	polyribonucleotide nucleotidyltransferase activity
CRM98_RS07635	COG0539	negative regulation of cytoplasmic translation
CRM98_RS07645	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CRM98_RS07650	COG0745	RESPONSE REGULATOR receiver
CRM98_RS07655	COG5002	protein histidine kinase activity
CRM98_RS07660	COG0488	(ABC) transporter
CRM98_RS07675	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CRM98_RS07680	COG1674	ftsk spoiiie
CRM98_RS07680	COG1196	nuclear chromosome segregation
CRM98_RS07685	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CRM98_RS07690	COG1959	2 iron, 2 sulfur cluster binding
CRM98_RS07695	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CRM98_RS07700	COG2404	hydrolase activity, acting on ester bonds
CRM98_RS07730	COG3258	Cytochrome c
CRM98_RS07735	COG3258	Cytochrome c
CRM98_RS07750	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CRM98_RS07760	COG0582	viral genome integration into host DNA
CRM98_RS07765	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CRM98_RS07770	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CRM98_RS07770	COG0512	Glutamine amidotransferase of anthranilate synthase
CRM98_RS07785	COG0303	'Molybdopterin
CRM98_RS07790	COG0681	Belongs to the peptidase S26 family
CRM98_RS07795	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CRM98_RS07835	COG0688	phosphatidylethanolamine metabolic process
CRM98_RS07840	COG1408	metallophosphoesterase
CRM98_RS07845	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CRM98_RS07870	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CRM98_RS07880	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRM98_RS07880	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CRM98_RS07890	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CRM98_RS07895	COG1049	propionate catabolic process, 2-methylcitrate cycle
CRM98_RS07905	COG4221	oxidoreductase activity
CRM98_RS07910	COG1757	Na H antiporter
CRM98_RS07915	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CRM98_RS07930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CRM98_RS07935	COG0101	tRNA pseudouridine synthase activity
CRM98_RS07965	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CRM98_RS07970	COG1338	Plays a role in the flagellum-specific transport system
CRM98_RS07985	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CRM98_RS08000	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CRM98_RS08005	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CRM98_RS08010	COG1663	tetraacyldisaccharide 4'-kinase activity
CRM98_RS08015	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CRM98_RS08030	COG1028	Short-chain dehydrogenase reductase Sdr
CRM98_RS08035	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CRM98_RS08040	COG0612	Peptidase, M16
CRM98_RS08045	COG0167	dihydroorotate dehydrogenase activity
CRM98_RS08050	COG1132	(ABC) transporter
CRM98_RS08055	COG0215	cysteine-tRNA ligase activity
CRM98_RS08060	COG0728	peptidoglycan biosynthetic process
CRM98_RS08070	COG0632	four-way junction helicase activity
CRM98_RS08075	COG1181	Belongs to the D-alanine--D-alanine ligase family
CRM98_RS08100	COG0642	Histidine kinase
CRM98_RS08110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CRM98_RS08115	COG0788	formyltetrahydrofolate deformylase activity
CRM98_RS08150	COG3043	anaerobic respiration
CRM98_RS08155	COG0348	domain, Protein
CRM98_RS08160	COG0437	4 iron, 4 sulfur cluster binding
CRM98_RS08170	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CRM98_RS08180	COG0210	DNA helicase
CRM98_RS08195	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CRM98_RS08200	COG2011	ABC-type metal ion transport system permease component
CRM98_RS08205	COG1464	Belongs to the NlpA lipoprotein family
CRM98_RS08210	COG1464	Belongs to the NlpA lipoprotein family
CRM98_RS08215	COG1464	Belongs to the NlpA lipoprotein family
CRM98_RS08225	COG0163	prenyltransferase activity
CRM98_RS08230	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CRM98_RS08245	COG1166	arginine decarboxylase activity
CRM98_RS08250	COG1045	serine acetyltransferase
CRM98_RS08255	COG0436	Aminotransferase
CRM98_RS08270	COG0443	Heat shock 70 kDa protein
CRM98_RS08275	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CRM98_RS08280	COG1420	regulation of RNA biosynthetic process
CRM98_RS08285	COG4771	TonB-dependent receptor
CRM98_RS08295	COG0675	Transposase, IS605 OrfB family
CRM98_RS08380	COG3842	ATPase activity
CRM98_RS08410	COG0598	Magnesium transport protein CorA
CRM98_RS08415	COG0521	Mo-molybdopterin cofactor biosynthetic process
CRM98_RS08425	COG0501	Belongs to the peptidase M48B family
CRM98_RS08430	COG2890	protein-(glutamine-N5) methyltransferase activity
CRM98_RS08445	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CRM98_RS08450	COG0587	DNA-directed DNA polymerase activity
CRM98_RS08460	COG1393	Belongs to the ArsC family
CRM98_RS08465	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CRM98_RS08480	COG0336	Belongs to the RNA methyltransferase TrmD family
CRM98_RS08485	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CRM98_RS08490	COG1837	Belongs to the UPF0109 family
CRM98_RS08495	COG0228	four-way junction DNA binding
CRM98_RS08500	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CRM98_RS08505	COG0564	pseudouridine synthase activity
CRM98_RS08510	COG1519	Transferase
CRM98_RS08510	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CRM98_RS08520	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CRM98_RS08525	COG0752	glycyl-tRNA synthetase alpha subunit
CRM98_RS08535	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CRM98_RS08540	COG0826	peptidase U32
CRM98_RS08550	COG0174	glutamine synthetase
CRM98_RS08555	COG4786	Flagellar basal body rod
CRM98_RS08560	COG4786	Flagellar basal body rod
CRM98_RS08565	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CRM98_RS08570	COG0849	cell division
CRM98_RS08575	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CRM98_RS08580	COG0275	rRNA processing
CRM98_RS08605	COG0280	phosphate acetyltransferase
CRM98_RS08615	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CRM98_RS08625	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CRM98_RS08660	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
CRM98_RS08665	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
CRM98_RS08690	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CRM98_RS08695	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CRM98_RS08700	COG1137	ATPase activity
CRM98_RS08705	COG0802	atpase or kinase
CRM98_RS08710	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CRM98_RS08715	COG0137	argininosuccinate synthase activity
CRM98_RS08730	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
CRM98_RS08735	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CRM98_RS08780	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CRM98_RS08800	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CRM98_RS08805	COG0791	NLP P60 protein
CRM98_RS08805	COG1388	LysM domain
CRM98_RS08810	COG0084	hydrolase, TatD family'
CRM98_RS08820	COG0497	DNA recombination
CRM98_RS08840	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CRM98_RS08860	COG0758	DNA mediated transformation
CRM98_RS08875	COG0557	exoribonuclease II activity