locus-tag	class	description
BLD38_RS00005	COG0811	peptide transport
BLD38_RS00010	COG0848	biopolymer transport protein
BLD38_RS00040	COG0571	ribonuclease III activity
BLD38_RS00045	COG0328	RNA-DNA hybrid ribonuclease activity
BLD38_RS00055	COG0358	DNA primase activity
BLD38_RS00070	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
BLD38_RS00075	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
BLD38_RS00090	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
BLD38_RS00095	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
BLD38_RS00100	COG1127	ABC transporter
BLD38_RS00110	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
BLD38_RS00110	COG3218	ABC-type transport auxiliary lipoprotein component
BLD38_RS00120	COG0024	Methionine aminopeptidase
BLD38_RS00125	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
BLD38_RS00130	COG0791	NLP P60 protein
BLD38_RS00150	COG0672	)-iron permease
BLD38_RS00170	COG1136	(ABC) transporter
BLD38_RS00170	COG0577	efflux transmembrane transporter activity
BLD38_RS00175	COG1136	(ABC) transporter
BLD38_RS00245	COG0148	phosphopyruvate hydratase activity
BLD38_RS00250	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
BLD38_RS00255	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BLD38_RS00260	COG1987	bacterial-type flagellum assembly
BLD38_RS00275	COG1218	3'(2'),5'-bisphosphate nucleotidase
BLD38_RS00280	COG0372	Belongs to the citrate synthase family
BLD38_RS00295	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
BLD38_RS00305	COG0201	protein transport
BLD38_RS00310	COG0200	Binds to the 23S rRNA
BLD38_RS00315	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
BLD38_RS00320	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
BLD38_RS00325	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
BLD38_RS00330	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
BLD38_RS00335	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
BLD38_RS00340	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
BLD38_RS00345	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
BLD38_RS00350	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
BLD38_RS00355	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
BLD38_RS00360	COG0255	Belongs to the universal ribosomal protein uL29 family
BLD38_RS00365	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
BLD38_RS00370	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
BLD38_RS00380	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
BLD38_RS00400	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
BLD38_RS00405	COG0051	transcription antitermination factor activity, RNA binding
BLD38_RS00410	COG1187	pseudouridine synthase activity
BLD38_RS00415	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
BLD38_RS00500	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
BLD38_RS00510	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
BLD38_RS00525	COG1749	Flagellar hook protein flgE
BLD38_RS00540	COG0592	DNA-directed DNA polymerase activity
BLD38_RS00545	COG0187	DNA topoisomerase II activity
BLD38_RS00560	COG2056	Na+-H+ antiporter family
BLD38_RS00565	COG0067	glutamate synthase
BLD38_RS00565	COG0069	glutamate synthase activity
BLD38_RS00565	COG0070	glutamate synthase
BLD38_RS00570	COG0493	'glutamate synthase
BLD38_RS00575	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
BLD38_RS00585	COG1592	Rubrerythrin
BLD38_RS00590	COG0129	dihydroxy-acid dehydratase activity
BLD38_RS00605	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
BLD38_RS00625	COG1858	cytochrome C peroxidase
BLD38_RS00630	COG0179	Fumarylacetoacetate (FAA) hydrolase
BLD38_RS00660	COG3258	Cytochrome c
BLD38_RS00685	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
BLD38_RS00690	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
BLD38_RS00695	COG0582	viral genome integration into host DNA
BLD38_RS00700	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
BLD38_RS00705	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BLD38_RS00705	COG0512	Glutamine amidotransferase of anthranilate synthase
BLD38_RS00720	COG0303	'Molybdopterin
BLD38_RS00725	COG0681	Belongs to the peptidase S26 family
BLD38_RS00730	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
BLD38_RS00770	COG0688	phosphatidylethanolamine metabolic process
BLD38_RS00775	COG1408	metallophosphoesterase
BLD38_RS00805	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
BLD38_RS00815	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BLD38_RS00815	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BLD38_RS00825	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
BLD38_RS00830	COG1049	propionate catabolic process, 2-methylcitrate cycle
BLD38_RS00840	COG4221	oxidoreductase activity
BLD38_RS00845	COG1757	Na H antiporter
BLD38_RS00865	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
BLD38_RS00900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
BLD38_RS00905	COG1338	Plays a role in the flagellum-specific transport system
BLD38_RS00915	COG0564	pseudouridine synthase activity
BLD38_RS00920	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
BLD38_RS00925	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BLD38_RS00940	COG0504	CTP synthase activity
BLD38_RS00950	COG0252	asparaginase activity
BLD38_RS01000	COG2814	Major facilitator Superfamily
BLD38_RS01020	COG1217	gtp-binding protein TYPA
BLD38_RS01035	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
BLD38_RS01075	COG0471	metal ion transport
BLD38_RS01110	COG1776	CheC inhibitor of MCP methylation
BLD38_RS01110	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BLD38_RS01115	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BLD38_RS01120	COG1191	sigma factor activity
BLD38_RS01130	COG0455	bacterial-type flagellum organization
BLD38_RS01135	COG1419	protein localization to endoplasmic reticulum
BLD38_RS01140	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
BLD38_RS01145	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
BLD38_RS01150	COG0402	S-adenosylhomocysteine deaminase activity
BLD38_RS01155	COG0616	signal peptide processing
BLD38_RS01185	COG1139	Iron-sulfur cluster binding protein
BLD38_RS01190	COG0247	lactate metabolic process
BLD38_RS01205	COG3021	interspecies interaction between organisms
BLD38_RS01220	COG1271	oxidase subunit
BLD38_RS01225	COG1294	oxidase, subunit
BLD38_RS01235	COG1794	racemase activity, acting on amino acids and derivatives
BLD38_RS01245	COG1027	Aspartate ammonia-lyase
BLD38_RS01250	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
BLD38_RS01280	COG0261	This protein binds to 23S rRNA in the presence of protein L20
BLD38_RS01285	COG0211	Belongs to the bacterial ribosomal protein bL27 family
BLD38_RS01305	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
BLD38_RS01305	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
BLD38_RS01310	COG1192	Involved in chromosome partitioning
BLD38_RS01315	COG1475	DNA binding
BLD38_RS01325	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
BLD38_RS01330	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
BLD38_RS01345	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
BLD38_RS01350	COG0355	proton-transporting ATP synthase activity, rotational mechanism
BLD38_RS01355	COG0811	peptide transport
BLD38_RS01360	COG0848	biopolymer transport protein
BLD38_RS01370	COG0823	Involved in the tonB-independent uptake of proteins
BLD38_RS01375	COG2885	chlorophyll binding
BLD38_RS01385	COG1047	Peptidyl-prolyl cis-trans
BLD38_RS01390	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
BLD38_RS01395	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
BLD38_RS01400	COG0037	tRNA processing
BLD38_RS01425	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
BLD38_RS01435	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
BLD38_RS01445	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
BLD38_RS01455	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
BLD38_RS01480	COG0083	homoserine kinase activity
BLD38_RS01490	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
BLD38_RS01505	COG1401	restriction endodeoxyribonuclease activity
BLD38_RS01515	COG1108	ABC-type Mn2 Zn2 transport systems permease components
BLD38_RS01520	COG1121	(ABC) transporter
BLD38_RS01530	COG0840	transmembrane signaling receptor activity
BLD38_RS01540	COG0492	ferredoxin-NADP+ reductase activity
BLD38_RS01545	COG3118	belongs to the thioredoxin family
BLD38_RS01550	COG0792	nuclease activity
BLD38_RS01555	COG0460	homoserine dehydrogenase
BLD38_RS01560	COG0436	Aminotransferase
BLD38_RS01575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
BLD38_RS01580	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
BLD38_RS01585	COG0254	rRNA binding
BLD38_RS01590	COG1385	rRNA (uridine-N3-)-methyltransferase activity
BLD38_RS01610	COG0602	queuosine metabolic process
BLD38_RS01615	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
BLD38_RS01640	COG1971	Probably functions as a manganese efflux pump
BLD38_RS01655	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
BLD38_RS01685	COG1840	ABC-type Fe3 transport system, periplasmic component
BLD38_RS01700	COG4206	TonB-dependent receptor
BLD38_RS01700	COG1629	transport
BLD38_RS01705	COG0811	peptide transport
BLD38_RS01710	COG0848	biopolymer transport protein
BLD38_RS01720	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
BLD38_RS01725	COG1253	flavin adenine dinucleotide binding
BLD38_RS01735	COG2824	Alkylphosphonate utilization operon protein PhnA
BLD38_RS01740	COG0861	Integral membrane protein TerC family
BLD38_RS01745	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
BLD38_RS01750	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
BLD38_RS01750	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
BLD38_RS01760	COG0606	chelatase, subunit chli
BLD38_RS01765	COG0242	peptide deformylase activity
BLD38_RS01775	COG0544	peptidyl-prolyl cis-trans isomerase activity
BLD38_RS01785	COG1157	protein secretion by the type III secretion system
BLD38_RS01790	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
BLD38_RS01795	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
BLD38_RS01800	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
BLD38_RS01800	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
BLD38_RS01825	COG2851	Citrate transporter
BLD38_RS01830	COG1297	OPT oligopeptide transporter protein
BLD38_RS01845	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
BLD38_RS01895	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
BLD38_RS01900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
BLD38_RS01905	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
BLD38_RS01920	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
BLD38_RS01940	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
BLD38_RS01945	COG0670	Belongs to the BI1 family
BLD38_RS01950	COG0288	reversible hydration of carbon dioxide
BLD38_RS01955	COG0668	transmembrane transport
BLD38_RS01980	COG0291	Belongs to the bacterial ribosomal protein bL35 family
BLD38_RS01985	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
BLD38_RS02010	COG0477	Major facilitator Superfamily
BLD38_RS02025	COG2921	Belongs to the UPF0250 family
BLD38_RS02035	COG0708	Exodeoxyribonuclease III
BLD38_RS02040	COG2194	sulfuric ester hydrolase activity
BLD38_RS02045	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
BLD38_RS02055	COG0418	dihydroorotase activity
BLD38_RS02065	COG2226	methyltransferase
BLD38_RS02085	COG0330	HflC and HflK could
BLD38_RS02095	COG1942	4-Oxalocrotonate Tautomerase
BLD38_RS02100	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
BLD38_RS02105	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
BLD38_RS02120	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
BLD38_RS02125	COG1077	Cell shape determining protein MreB Mrl
BLD38_RS02135	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
BLD38_RS02155	COG0835	chemotaxis
BLD38_RS02160	COG2198	Histidine kinase
BLD38_RS02160	COG0784	Response regulator, receiver
BLD38_RS02160	COG0643	Histidine kinase
BLD38_RS02165	COG0835	chemotaxis
BLD38_RS02165	COG0784	Response regulator, receiver
BLD38_RS02175	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
BLD38_RS02195	COG2189	Belongs to the N(4) N(6)-methyltransferase family
BLD38_RS02230	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
BLD38_RS02250	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
BLD38_RS02270	COG4106	trans-aconitate 2-methyltransferase activity
BLD38_RS02285	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
BLD38_RS02300	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
BLD38_RS02305	COG2076	Multidrug Resistance protein
BLD38_RS02330	COG0019	diaminopimelate decarboxylase activity
BLD38_RS02355	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BLD38_RS02365	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
BLD38_RS02385	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BLD38_RS02410	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BLD38_RS02415	COG0802	atpase or kinase
BLD38_RS02420	COG1137	ATPase activity
BLD38_RS02425	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BLD38_RS02440	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BLD38_RS02445	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BLD38_RS02580	COG4397	Mu-like prophage major head subunit gpT
BLD38_RS02625	COG4383	Mu-like prophage protein gp29
BLD38_RS02715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
BLD38_RS02720	COG0556	nucleotide-excision repair
BLD38_RS02740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
BLD38_RS02750	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BLD38_RS02760	COG0280	phosphate acetyltransferase
BLD38_RS02790	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BLD38_RS02795	COG0849	cell division
BLD38_RS02800	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BLD38_RS02805	COG4786	Flagellar basal body rod
BLD38_RS02810	COG4786	Flagellar basal body rod
BLD38_RS02815	COG0174	glutamine synthetase
BLD38_RS02825	COG0826	peptidase U32
BLD38_RS02830	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BLD38_RS02845	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BLD38_RS02855	COG1519	Transferase
BLD38_RS02855	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BLD38_RS02860	COG0564	pseudouridine synthase activity
BLD38_RS02865	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BLD38_RS02870	COG0228	four-way junction DNA binding
BLD38_RS02875	COG1837	Belongs to the UPF0109 family
BLD38_RS02900	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BLD38_RS02905	COG1393	Belongs to the ArsC family
BLD38_RS02910	COG0587	DNA-directed DNA polymerase activity
BLD38_RS02915	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BLD38_RS02930	COG2890	protein-(glutamine-N5) methyltransferase activity
BLD38_RS02935	COG0501	Belongs to the peptidase M48B family
BLD38_RS02945	COG0521	Mo-molybdopterin cofactor biosynthetic process
BLD38_RS02980	COG3842	ATPase activity
BLD38_RS02995	COG2226	methyltransferase
BLD38_RS03000	COG1570	exodeoxyribonuclease VII activity
BLD38_RS03005	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
BLD38_RS03010	COG0251	oxidation-reduction process
BLD38_RS03015	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BLD38_RS03020	COG0416	fatty acid biosynthetic process
BLD38_RS03025	COG0333	Belongs to the bacterial ribosomal protein bL32 family
BLD38_RS03035	COG0105	UTP biosynthetic process
BLD38_RS03045	COG0450	alkyl hydroperoxide reductase
BLD38_RS03050	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BLD38_RS03055	COG1360	Flagellar Motor Protein
BLD38_RS03060	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
BLD38_RS03070	COG0477	Major facilitator Superfamily
BLD38_RS03080	COG1238	metal cluster binding
BLD38_RS03085	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
BLD38_RS03090	COG0730	response to heat
BLD38_RS03105	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
BLD38_RS03105	COG0512	Glutamine amidotransferase of anthranilate synthase
BLD38_RS03115	COG0133	tryptophan synthase activity
BLD38_RS03120	COG0159	tryptophan synthase activity
BLD38_RS03130	COG1776	CheC inhibitor of MCP methylation
BLD38_RS03130	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
BLD38_RS03145	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
BLD38_RS03150	COG0745	RESPONSE REGULATOR receiver
BLD38_RS03160	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
BLD38_RS03175	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
BLD38_RS03180	COG1981	membrane
BLD38_RS03185	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BLD38_RS03195	COG1538	Outer membrane efflux protein
BLD38_RS03205	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BLD38_RS03220	COG0828	Belongs to the bacterial ribosomal protein bS21 family
BLD38_RS03230	COG0754	glutathionylspermidine amidase activity
BLD38_RS03235	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
BLD38_RS03260	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
BLD38_RS03265	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
BLD38_RS03285	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
BLD38_RS03315	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
BLD38_RS03330	COG0469	pyruvate kinase activity
BLD38_RS03335	COG0579	oxidoreductase
BLD38_RS03340	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
BLD38_RS03375	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
BLD38_RS03380	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
BLD38_RS03395	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
BLD38_RS03415	COG1053	succinate dehydrogenase
BLD38_RS03420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BLD38_RS03465	COG2353	YceI-like domain
BLD38_RS03495	COG0488	(ABC) transporter
BLD38_RS03510	COG1739	Uncharacterized protein family UPF0029
BLD38_RS03550	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
BLD38_RS03570	COG1028	Short-chain dehydrogenase reductase Sdr
BLD38_RS03580	COG1053	succinate dehydrogenase
BLD38_RS03585	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
BLD38_RS03590	COG2048	Heterodisulfide reductase, subunit B
BLD38_RS03595	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
BLD38_RS03600	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
BLD38_RS03605	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
BLD38_RS03610	COG0825	malonyl-CoA metabolic process
BLD38_RS03635	COG0227	Belongs to the bacterial ribosomal protein bL28 family
BLD38_RS03640	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
BLD38_RS03670	COG2121	Domain of unknown function (DUF374)
BLD38_RS03685	COG0195	Participates in both transcription termination and antitermination
BLD38_RS03695	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BLD38_RS03700	COG0612	Peptidase, M16
BLD38_RS03705	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
BLD38_RS03710	COG2346	COG2346, Truncated hemoglobins
BLD38_RS03725	COG0765	amino acid transport
BLD38_RS03755	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
BLD38_RS03760	COG0267	Belongs to the bacterial ribosomal protein bL33 family
BLD38_RS03775	COG0250	Participates in transcription elongation, termination and antitermination
BLD38_RS03780	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
BLD38_RS03785	COG0081	regulation of translation
BLD38_RS03795	COG0222	ribosome binding
BLD38_RS03815	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BLD38_RS03830	COG2271	Major facilitator Superfamily
BLD38_RS03835	COG1028	Short-chain dehydrogenase reductase Sdr
BLD38_RS03840	COG0738	Major facilitator superfamily
BLD38_RS03850	COG3254	rhamnose metabolic process
BLD38_RS03855	COG1012	belongs to the aldehyde dehydrogenase family
BLD38_RS03860	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
BLD38_RS03865	COG0049	tRNA binding
BLD38_RS03910	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
BLD38_RS03915	COG0004	ammonium transporteR
BLD38_RS03925	COG0673	inositol 2-dehydrogenase activity
BLD38_RS03940	COG0424	maF-like protein
BLD38_RS03950	COG0542	response to heat
BLD38_RS03955	COG1937	Protein conserved in bacteria
BLD38_RS03960	COG0793	Belongs to the peptidase S41A family
BLD38_RS03965	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
BLD38_RS03970	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
BLD38_RS03975	COG0047	phosphoribosylformylglycinamidine synthase activity
BLD38_RS03985	COG0204	Acyl-transferase
BLD38_RS04000	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
BLD38_RS04020	COG1677	Flagellar hook-basal body complex protein FliE
BLD38_RS04025	COG1558	bacterial-type flagellum-dependent cell motility
BLD38_RS04030	COG1815	bacterial-type flagellum-dependent cell motility
BLD38_RS04050	COG0039	L-malate dehydrogenase activity
BLD38_RS04060	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
BLD38_RS04070	COG0674	pyruvate-flavodoxin oxidoreductase activity
BLD38_RS04070	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
BLD38_RS04075	COG1013	pyruvate-flavodoxin oxidoreductase activity
BLD38_RS04095	COG0142	geranyltranstransferase activity
BLD38_RS04100	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
BLD38_RS04105	COG0442	prolyl-tRNA aminoacylation
BLD38_RS04115	COG0181	hydroxymethylbilane synthase activity
BLD38_RS04120	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
BLD38_RS04130	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
BLD38_RS04150	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
BLD38_RS04180	COG1289	transmembrane transporter activity
BLD38_RS04185	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
BLD38_RS04190	COG0492	ferredoxin-NADP+ reductase activity
BLD38_RS04205	COG0305	Participates in initiation and elongation during chromosome replication
BLD38_RS04240	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BLD38_RS04240	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BLD38_RS04245	COG1610	YqeY-like protein
BLD38_RS04250	COG0028	Belongs to the TPP enzyme family
BLD38_RS04255	COG0440	acetolactate synthase activity
BLD38_RS04270	COG0805	protein transport
BLD38_RS04280	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BLD38_RS04285	COG0494	nUDIX hydrolase
BLD38_RS04290	COG0527	aspartate kinase activity
BLD38_RS04305	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
BLD38_RS04325	COG0196	riboflavin kinase activity
BLD38_RS04330	COG2890	protein-(glutamine-N5) methyltransferase activity
BLD38_RS04345	COG2860	membrane
BLD38_RS04355	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
BLD38_RS04360	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BLD38_RS04365	COG0191	fructose-bisphosphate aldolase activity
BLD38_RS04385	COG0733	neurotransmitter:sodium symporter activity
BLD38_RS04390	COG2258	MOSC domain
BLD38_RS04405	COG1473	amidohydrolase
BLD38_RS04410	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
BLD38_RS04415	COG1136	(ABC) transporter
BLD38_RS04415	COG0577	efflux transmembrane transporter activity
BLD38_RS04420	COG1538	Outer membrane efflux protein
BLD38_RS04435	COG1696	Membrane protein involved in D-alanine export
BLD38_RS04440	COG1528	Iron-storage protein
BLD38_RS04445	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
BLD38_RS04450	COG0573	inorganic phosphate transmembrane transporter activity
BLD38_RS04455	COG0581	inorganic phosphate transmembrane transporter activity
BLD38_RS04470	COG0534	Mate efflux family protein
BLD38_RS04485	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
BLD38_RS04495	COG0298	carbon dioxide binding
BLD38_RS04500	COG0409	Hydrogenase expression formation protein
BLD38_RS04505	COG0309	Hydrogenase expression formation protein (HypE)
BLD38_RS04510	COG0375	protein maturation
BLD38_RS04525	COG0557	exoribonuclease II activity
BLD38_RS04530	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
BLD38_RS04540	COG0758	DNA mediated transformation
BLD38_RS04560	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
BLD38_RS04570	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
BLD38_RS04575	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
BLD38_RS04580	COG0497	DNA recombination
BLD38_RS04590	COG0084	hydrolase, TatD family'
BLD38_RS04595	COG0791	NLP P60 protein
BLD38_RS04595	COG1388	LysM domain
BLD38_RS04600	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
BLD38_RS04675	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
BLD38_RS04700	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
BLD38_RS04705	COG0802	atpase or kinase
BLD38_RS04710	COG1137	ATPase activity
BLD38_RS04715	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
BLD38_RS04730	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BLD38_RS04735	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
BLD38_RS04745	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
BLD38_RS04750	COG2205	protein histidine kinase activity
BLD38_RS04755	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
BLD38_RS04765	COG0280	phosphate acetyltransferase
BLD38_RS04795	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
BLD38_RS04800	COG0849	cell division
BLD38_RS04805	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
BLD38_RS04810	COG4786	Flagellar basal body rod
BLD38_RS04815	COG4786	Flagellar basal body rod
BLD38_RS04820	COG0174	glutamine synthetase
BLD38_RS04830	COG0826	peptidase U32
BLD38_RS04835	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
BLD38_RS04850	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
BLD38_RS04860	COG0220	tRNA (guanine-N7-)-methyltransferase activity
BLD38_RS04860	COG1519	Transferase
BLD38_RS04865	COG0564	pseudouridine synthase activity
BLD38_RS04870	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
BLD38_RS04875	COG0228	four-way junction DNA binding
BLD38_RS04880	COG1837	Belongs to the UPF0109 family
BLD38_RS04905	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
BLD38_RS04910	COG1393	Belongs to the ArsC family
BLD38_RS04915	COG0587	DNA-directed DNA polymerase activity
BLD38_RS04920	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
BLD38_RS04935	COG2890	protein-(glutamine-N5) methyltransferase activity
BLD38_RS04940	COG0501	Belongs to the peptidase M48B family
BLD38_RS04950	COG0521	Mo-molybdopterin cofactor biosynthetic process
BLD38_RS04985	COG3842	ATPase activity
BLD38_RS05080	COG0675	Transposase, IS605 OrfB family
BLD38_RS05090	COG4771	TonB-dependent receptor
BLD38_RS05095	COG1420	regulation of RNA biosynthetic process
BLD38_RS05105	COG0443	Heat shock 70 kDa protein
BLD38_RS05120	COG0436	Aminotransferase
BLD38_RS05125	COG1045	serine acetyltransferase
BLD38_RS05130	COG1166	arginine decarboxylase activity
BLD38_RS05145	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
BLD38_RS05150	COG0163	prenyltransferase activity
BLD38_RS05160	COG1464	Belongs to the NlpA lipoprotein family
BLD38_RS05165	COG1464	Belongs to the NlpA lipoprotein family
BLD38_RS05170	COG1464	Belongs to the NlpA lipoprotein family
BLD38_RS05175	COG2011	ABC-type metal ion transport system permease component
BLD38_RS05180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BLD38_RS05195	COG0210	DNA helicase
BLD38_RS05205	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
BLD38_RS05215	COG0437	4 iron, 4 sulfur cluster binding
BLD38_RS05220	COG0348	domain, Protein
BLD38_RS05225	COG3043	anaerobic respiration
BLD38_RS05260	COG0788	formyltetrahydrofolate deformylase activity
BLD38_RS05265	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
BLD38_RS05275	COG0642	Histidine kinase
BLD38_RS05300	COG1181	Belongs to the D-alanine--D-alanine ligase family
BLD38_RS05305	COG0632	four-way junction helicase activity
BLD38_RS05315	COG0728	peptidoglycan biosynthetic process
BLD38_RS05320	COG0215	cysteine-tRNA ligase activity
BLD38_RS05325	COG1132	(ABC) transporter
BLD38_RS05330	COG0167	dihydroorotate dehydrogenase activity
BLD38_RS05335	COG0612	Peptidase, M16
BLD38_RS05340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
BLD38_RS05345	COG1028	Short-chain dehydrogenase reductase Sdr
BLD38_RS05360	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
BLD38_RS05365	COG1663	tetraacyldisaccharide 4'-kinase activity
BLD38_RS05370	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
BLD38_RS05375	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
BLD38_RS05380	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
BLD38_RS05385	COG1959	2 iron, 2 sulfur cluster binding
BLD38_RS05390	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
BLD38_RS05395	COG1674	ftsk spoiiie
BLD38_RS05395	COG1196	nuclear chromosome segregation
BLD38_RS05400	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BLD38_RS05415	COG0488	(ABC) transporter
BLD38_RS05420	COG5002	protein histidine kinase activity
BLD38_RS05425	COG0745	RESPONSE REGULATOR receiver
BLD38_RS05430	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
BLD38_RS05440	COG0539	negative regulation of cytoplasmic translation
BLD38_RS05440	COG1185	polyribonucleotide nucleotidyltransferase activity
BLD38_RS05450	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
BLD38_RS05455	COG0072	phenylalanine-tRNA ligase activity
BLD38_RS05455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
BLD38_RS05460	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
BLD38_RS05465	COG0537	adenosine 5'-monophosphoramidase activity
BLD38_RS05480	COG0765	amino acid transport
BLD38_RS05490	COG1115	amino acid carrier protein
BLD38_RS05495	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
BLD38_RS05525	COG1999	signal sequence binding
BLD38_RS05530	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
BLD38_RS05535	COG0776	regulation of translation
BLD38_RS05555	COG1966	Carbon starvation protein
BLD38_RS05560	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
BLD38_RS05565	COG0765	amino acid transport
BLD38_RS05570	COG0765	amino acid transport
BLD38_RS05575	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLD38_RS05580	COG1126	abc transporter atp-binding protein
BLD38_RS05585	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
BLD38_RS05590	COG2201	protein-glutamate methylesterase activity
BLD38_RS05615	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
BLD38_RS05620	COG0012	GTP binding
BLD38_RS05630	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
BLD38_RS05635	COG5016	pyruvate
BLD38_RS05635	COG0511	ligase activity, forming carbon-carbon bonds
BLD38_RS05640	COG0733	neurotransmitter:sodium symporter activity
BLD38_RS05645	COG0733	neurotransmitter:sodium symporter activity
BLD38_RS05665	COG0204	Acyl-transferase
BLD38_RS05665	COG0318	PFAM AMP-dependent synthetase and ligase
BLD38_RS05710	COG0765	amino acid transport
BLD38_RS05720	COG0653	protein targeting
BLD38_RS05725	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
BLD38_RS05750	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
BLD38_RS05765	COG0840	transmembrane signaling receptor activity
BLD38_RS05780	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
BLD38_RS05790	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
BLD38_RS05800	COG0706	membrane insertase activity
BLD38_RS05815	COG0230	Belongs to the bacterial ribosomal protein bL34 family
BLD38_RS05835	COG0824	Thioesterase
BLD38_RS05885	COG2195	Cleaves the N-terminal amino acid of tripeptides
BLD38_RS05890	COG0477	Major facilitator Superfamily
BLD38_RS05895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
BLD38_RS05905	COG3022	response to hydroperoxide
BLD38_RS05910	COG1473	amidohydrolase
BLD38_RS05940	COG2181	nitrate reductase activity
BLD38_RS05940	COG0247	lactate metabolic process
BLD38_RS05945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
BLD38_RS05955	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
BLD38_RS05960	COG0113	porphobilinogen synthase activity
BLD38_RS05965	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
BLD38_RS05970	COG0357	Ribosomal RNA small subunit methyltransferase G
BLD38_RS05980	COG2855	membrane
BLD38_RS05985	COG0583	DNA-binding transcription factor activity
BLD38_RS05990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
BLD38_RS06010	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BLD38_RS06015	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
BLD38_RS06035	COG0343	queuine tRNA-ribosyltransferase activity
BLD38_RS06055	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
BLD38_RS06055	COG1333	cytochrome c biogenesis protein
BLD38_RS06080	COG0683	leucine binding
BLD38_RS06105	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
BLD38_RS06110	COG2204	response regulator
BLD38_RS06125	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
BLD38_RS06140	COG0481	GTPase activity
BLD38_RS06165	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
BLD38_RS06175	COG0439	Biotin carboxylase
BLD38_RS06180	COG0772	Belongs to the SEDS family
BLD38_RS06185	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
BLD38_RS06205	COG0352	thiamine-phosphate diphosphorylase activity
BLD38_RS06210	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
BLD38_RS06255	COG1193	negative regulation of DNA recombination
BLD38_RS06280	COG0516	GMP reductase activity
BLD38_RS06280	COG0517	IMP dehydrogenase activity
BLD38_RS06300	COG1058	Belongs to the CinA family
BLD38_RS06300	COG1546	Belongs to the CinA family
BLD38_RS06305	COG0456	acetyltransferase
BLD38_RS06310	COG0778	Nitroreductase
BLD38_RS06315	COG0778	Nitroreductase
BLD38_RS06325	COG0750	zinc metalloprotease
BLD38_RS06330	COG2990	Protein conserved in bacteria
BLD38_RS06340	COG0629	single-stranded DNA binding
BLD38_RS06345	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
BLD38_RS06350	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
BLD38_RS06360	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
BLD38_RS06365	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
BLD38_RS06410	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
BLD38_RS06420	COG0739	heme binding
BLD38_RS06425	COG0285	dihydrofolate synthase activity
BLD38_RS06445	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BLD38_RS06450	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
BLD38_RS06455	COG1862	Preprotein translocase
BLD38_RS06460	COG0815	Transfers the fatty acyl group on membrane lipoproteins
BLD38_RS06465	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
BLD38_RS06470	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
BLD38_RS06475	COG0540	Belongs to the ATCase OTCase family
BLD38_RS06490	COG0210	DNA helicase
BLD38_RS06510	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
BLD38_RS06525	COG0542	response to heat
BLD38_RS06530	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
BLD38_RS06540	COG2095	MarC family integral membrane protein
BLD38_RS06545	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
BLD38_RS06550	COG2833	Protein of unknown function (DUF455)
BLD38_RS06555	COG1183	phosphatidylcholine synthase activity
BLD38_RS06565	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
BLD38_RS06575	COG0745	RESPONSE REGULATOR receiver
BLD38_RS06585	COG1086	Polysaccharide biosynthesis protein
BLD38_RS06590	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BLD38_RS06595	COG0110	maltose O-acetyltransferase activity
BLD38_RS06600	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
BLD38_RS06605	COG0438	transferase activity, transferring glycosyl groups
BLD38_RS06615	COG0438	transferase activity, transferring glycosyl groups
BLD38_RS06620	COG1215	transferase activity, transferring glycosyl groups
BLD38_RS06625	COG0438	transferase activity, transferring glycosyl groups
BLD38_RS06630	COG1132	(ABC) transporter
BLD38_RS06635	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
BLD38_RS06645	COG0859	PFAM glycosyl transferase family 9
BLD38_RS06650	COG1560	Kdo2-lipid A biosynthetic process
BLD38_RS06675	COG1216	Glycosyl transferase, family 2
BLD38_RS06705	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BLD38_RS06720	COG2217	Heavy metal translocating P-type atpase
BLD38_RS06725	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
BLD38_RS06730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
BLD38_RS06740	COG2217	Heavy metal translocating P-type atpase
BLD38_RS06760	COG3610	response to peptide
BLD38_RS06770	COG0039	L-malate dehydrogenase activity
BLD38_RS06775	COG0586	Pfam SNARE associated Golgi protein
BLD38_RS06790	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
BLD38_RS06795	COG0217	transcriptional regulatory protein
BLD38_RS06815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
BLD38_RS06820	COG0194	GDP metabolic process
BLD38_RS06830	COG1684	flagellar biosynthetic protein fliR
BLD38_RS06845	COG0052	Belongs to the universal ribosomal protein uS2 family
BLD38_RS06850	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
BLD38_RS06860	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
BLD38_RS06865	COG0723	plastoquinol--plastocyanin reductase activity
BLD38_RS06875	COG0445	tRNA wobble uridine modification
BLD38_RS06895	COG1301	dicarboxylic acid transport
BLD38_RS06910	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
BLD38_RS06920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
BLD38_RS06925	COG1854	S-ribosylhomocysteine lyase activity
BLD38_RS06935	COG1464	Belongs to the NlpA lipoprotein family
BLD38_RS06945	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
BLD38_RS06960	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
BLD38_RS06965	COG0552	protein localization to endoplasmic reticulum
BLD38_RS06995	COG1295	ribonuclease BN
BLD38_RS07000	COG0277	FAD linked oxidase domain protein
BLD38_RS07010	COG0739	heme binding
BLD38_RS07020	COG1496	oxidoreductase activity
BLD38_RS07035	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
BLD38_RS07045	COG0642	Histidine kinase
BLD38_RS07050	COG0745	RESPONSE REGULATOR receiver
BLD38_RS07070	COG0642	Histidine kinase
BLD38_RS07075	COG0745	RESPONSE REGULATOR receiver
BLD38_RS07080	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
BLD38_RS07085	COG0484	heat shock protein binding
BLD38_RS07090	COG0789	Transcriptional regulator
BLD38_RS07095	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
BLD38_RS07095	COG0475	glutathione-regulated potassium exporter activity
BLD38_RS07105	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
BLD38_RS07110	COG0751	glycine-tRNA ligase activity
BLD38_RS07115	COG0739	heme binding
BLD38_RS07125	COG0248	Ppx GppA phosphatase
BLD38_RS07130	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
BLD38_RS07145	COG2814	Major facilitator Superfamily
BLD38_RS07160	COG0731	radical SAM domain protein
BLD38_RS07180	COG0518	GMP synthase (glutamine-hydrolyzing) activity
BLD38_RS07180	COG0519	Catalyzes the synthesis of GMP from XMP
BLD38_RS07225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
BLD38_RS07230	COG4773	Receptor
BLD38_RS07235	COG0484	heat shock protein binding
BLD38_RS07240	COG0745	RESPONSE REGULATOR receiver
BLD38_RS07245	COG0642	Histidine kinase
BLD38_RS07250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
BLD38_RS07255	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
BLD38_RS07260	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
BLD38_RS07265	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
BLD38_RS07270	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
BLD38_RS07275	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
BLD38_RS07275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
BLD38_RS07290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
BLD38_RS07295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
BLD38_RS07300	COG1758	RNA polymerase activity
BLD38_RS07305	COG0528	UMP kinase activity
BLD38_RS07320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
BLD38_RS07335	COG0564	pseudouridine synthase activity
BLD38_RS07340	COG0772	Belongs to the SEDS family
BLD38_RS07355	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
BLD38_RS07360	COG0569	domain protein
BLD38_RS07365	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
BLD38_RS07370	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
BLD38_RS07375	COG0280	phosphate acetyltransferase
BLD38_RS07375	COG0281	malic enzyme
BLD38_RS07390	COG0439	Biotin carboxylase
BLD38_RS07395	COG0511	ligase activity, forming carbon-carbon bonds
BLD38_RS07405	COG1086	Polysaccharide biosynthesis protein
BLD38_RS07410	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BLD38_RS07445	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
BLD38_RS07485	COG1083	cytidylyl-transferase
BLD38_RS07490	COG3980	spore coat polysaccharide biosynthesis protein
BLD38_RS07495	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
BLD38_RS07500	COG0107	imidazoleglycerol-phosphate synthase activity
BLD38_RS07515	COG2089	acid synthase
BLD38_RS07525	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BLD38_RS07530	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
BLD38_RS07535	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
BLD38_RS07550	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
BLD38_RS07570	COG2165	general secretion pathway protein
BLD38_RS07575	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
BLD38_RS07585	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
BLD38_RS07590	COG0575	Belongs to the CDS family
BLD38_RS07600	COG1293	RNA-binding protein homologous to eukaryotic snRNP
BLD38_RS07610	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
BLD38_RS07615	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BLD38_RS07620	COG4605	iron ion homeostasis
BLD38_RS07625	COG4604	ABC transporter, ATP-binding protein
BLD38_RS07630	COG4607	ABC-type enterochelin transport system periplasmic component
BLD38_RS07645	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
BLD38_RS07650	COG3005	denitrification pathway
BLD38_RS07685	COG2255	four-way junction helicase activity
BLD38_RS07690	COG0628	permease
BLD38_RS07695	COG0114	fumarate hydratase activity
BLD38_RS07705	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
BLD38_RS07715	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
BLD38_RS07720	COG2252	PERMEase
BLD38_RS07730	COG2853	Lipoprotein
BLD38_RS07750	COG2814	Major facilitator Superfamily
BLD38_RS07760	COG1921	L-seryl-tRNASec selenium transferase activity
BLD38_RS07765	COG3276	selenocysteine insertion sequence binding
BLD38_RS07780	COG0716	FMN binding
BLD38_RS07795	COG0753	catalase activity
BLD38_RS07805	COG2964	Protein conserved in bacteria
BLD38_RS07810	COG0251	oxidation-reduction process
BLD38_RS07815	COG3069	C4-dicarboxylate transmembrane transporter activity
BLD38_RS07835	COG1918	ferrous iron import across plasma membrane
BLD38_RS07845	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
BLD38_RS07850	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
BLD38_RS07865	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
BLD38_RS07890	COG1580	Controls the rotational direction of flagella during chemotaxis
BLD38_RS07895	COG0736	holo-[acyl-carrier-protein] synthase activity
BLD38_RS07905	COG2124	cytochrome p450
BLD38_RS07925	COG0529	Catalyzes the synthesis of activated sulfate
BLD38_RS07930	COG1213	nucleotidyl transferase
BLD38_RS07935	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
BLD38_RS07940	COG3848	Pyruvate phosphate dikinase
BLD38_RS07940	COG0574	Belongs to the PEP-utilizing enzyme family
BLD38_RS07945	COG2226	methyltransferase
BLD38_RS07970	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
BLD38_RS07990	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
BLD38_RS08005	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
BLD38_RS08025	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
BLD38_RS08025	COG0517	IMP dehydrogenase activity
BLD38_RS08070	COG0037	tRNA processing
BLD38_RS08095	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
BLD38_RS08120	COG3951	Flagellar rod assembly protein muramidase FlgJ
BLD38_RS08145	COG0730	response to heat
BLD38_RS08150	COG1459	type II secretion system
BLD38_RS08155	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
BLD38_RS08185	COG0546	phosphoglycolate phosphatase activity
BLD38_RS08195	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
BLD38_RS08200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
BLD38_RS08205	COG0210	DNA helicase
BLD38_RS08210	COG2887	Belongs to the helicase family. UvrD subfamily
BLD38_RS08255	COG0745	RESPONSE REGULATOR receiver
BLD38_RS08270	COG0505	Belongs to the CarA family
BLD38_RS08290	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
BLD38_RS08305	COG0425	Belongs to the sulfur carrier protein TusA family
BLD38_RS08310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
BLD38_RS08320	COG0709	Synthesizes selenophosphate from selenide and ATP
BLD38_RS08340	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
BLD38_RS08350	COG0437	4 iron, 4 sulfur cluster binding
BLD38_RS08360	COG3383	formate dehydrogenase (NAD+) activity
BLD38_RS08390	COG0314	molybdopterin synthase activity
BLD38_RS08395	COG0303	'Molybdopterin
BLD38_RS08400	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
BLD38_RS08410	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
BLD38_RS08415	COG3069	C4-dicarboxylate transmembrane transporter activity
BLD38_RS08420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
BLD38_RS08430	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
BLD38_RS08435	COG2992	FlgJ-related protein
BLD38_RS08445	COG0783	Belongs to the Dps family
BLD38_RS08450	COG0166	Belongs to the GPI family
BLD38_RS08460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
BLD38_RS08465	COG3839	Belongs to the ABC transporter superfamily
BLD38_RS08470	COG4662	Binding-protein-dependent transport system inner membrane component
BLD38_RS08475	COG2998	abc-type tungstate transport system, permease component
BLD38_RS08480	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
BLD38_RS08485	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
BLD38_RS08490	COG1984	allophanate hydrolase subunit 2
BLD38_RS08500	COG2249	NAD(P)H dehydrogenase (quinone) activity
BLD38_RS08505	COG1733	regulation of RNA biosynthetic process
BLD38_RS08515	COG1064	alcohol dehydrogenase
BLD38_RS08535	COG0732	type I restriction modification DNA specificity domain
BLD38_RS08580	COG0640	Transcriptional regulator
BLD38_RS08590	COG0798	PFAM Bile acid sodium symporter
BLD38_RS08615	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BLD38_RS08620	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
BLD38_RS08630	COG0839	Belongs to the complex I subunit 6 family
BLD38_RS08640	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
BLD38_RS08665	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BLD38_RS08675	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
BLD38_RS08690	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
BLD38_RS08695	COG0601	transmembrane transport
BLD38_RS08705	COG0277	FAD linked oxidase domain protein
BLD38_RS08720	COG4615	Cyclic peptide transporter
BLD38_RS08740	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
BLD38_RS08745	COG0257	Belongs to the bacterial ribosomal protein bL36 family
BLD38_RS08755	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
BLD38_RS08765	COG0202	RNA polymerase activity
BLD38_RS08770	COG0203	ribosomal protein L17
BLD38_RS08785	COG0131	Imidazoleglycerol-phosphate dehydratase
BLD38_RS08785	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
BLD38_RS08810	COG0140	phosphoribosyl-ATP diphosphatase activity
BLD38_RS08810	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
BLD38_RS08815	COG2171	N-acyltransferase activity
BLD38_RS08820	COG0489	protein tyrosine kinase activity
BLD38_RS08825	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
BLD38_RS08825	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
BLD38_RS08835	COG2046	Belongs to the sulfate adenylyltransferase family
BLD38_RS08840	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
BLD38_RS08845	COG0268	Binds directly to 16S ribosomal RNA
BLD38_RS08855	COG0748	coenzyme F420 binding
BLD38_RS08860	COG4771	TonB-dependent receptor
BLD38_RS08865	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
BLD38_RS08870	COG1120	ATPase activity
BLD38_RS08875	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
BLD38_RS08885	COG0477	Major facilitator Superfamily
BLD38_RS08890	COG1194	a g-specific adenine glycosylase
BLD38_RS08920	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BLD38_RS08920	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
BLD38_RS08930	COG1760	l-serine dehydratase
BLD38_RS08935	COG0814	amino acid