locus-tag	class	description
FORC46_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
FORC46_RS00010	COG0592	DNA-directed DNA polymerase activity
FORC46_RS00015	COG0187	DNA topoisomerase II activity
FORC46_RS00030	COG2056	Na+-H+ antiporter family
FORC46_RS00035	COG0067	glutamate synthase
FORC46_RS00035	COG0070	glutamate synthase
FORC46_RS00035	COG0069	glutamate synthase activity
FORC46_RS00040	COG0493	'glutamate synthase
FORC46_RS00045	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
FORC46_RS00055	COG1592	Rubrerythrin
FORC46_RS00060	COG0129	dihydroxy-acid dehydratase activity
FORC46_RS00065	COG3477	response to acidic pH
FORC46_RS00075	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
FORC46_RS00090	COG0840	transmembrane signaling receptor activity
FORC46_RS00095	COG1858	cytochrome C peroxidase
FORC46_RS00100	COG0179	Fumarylacetoacetate (FAA) hydrolase
FORC46_RS00105	COG0564	pseudouridine synthase activity
FORC46_RS00110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
FORC46_RS00115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC46_RS00140	COG0252	asparaginase activity
FORC46_RS00170	COG0484	heat shock protein binding
FORC46_RS00215	COG2814	Major facilitator Superfamily
FORC46_RS00250	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
FORC46_RS00280	COG0471	metal ion transport
FORC46_RS00290	COG0471	metal ion transport
FORC46_RS00295	COG0471	metal ion transport
FORC46_RS00305	COG1611	Belongs to the LOG family
FORC46_RS00340	COG1776	CheC inhibitor of MCP methylation
FORC46_RS00340	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC46_RS00345	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC46_RS00350	COG1191	sigma factor activity
FORC46_RS00360	COG0455	bacterial-type flagellum organization
FORC46_RS00365	COG1419	protein localization to endoplasmic reticulum
FORC46_RS00370	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
FORC46_RS00375	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
FORC46_RS00380	COG0402	S-adenosylhomocysteine deaminase activity
FORC46_RS00385	COG0616	signal peptide processing
FORC46_RS00405	COG1139	Iron-sulfur cluster binding protein
FORC46_RS00410	COG0247	lactate metabolic process
FORC46_RS00425	COG3021	interspecies interaction between organisms
FORC46_RS00440	COG1271	oxidase subunit
FORC46_RS00445	COG1294	oxidase, subunit
FORC46_RS00450	COG1794	racemase activity, acting on amino acids and derivatives
FORC46_RS00455	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
FORC46_RS00460	COG1027	Aspartate ammonia-lyase
FORC46_RS00465	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC46_RS00495	COG0261	This protein binds to 23S rRNA in the presence of protein L20
FORC46_RS00500	COG0211	Belongs to the bacterial ribosomal protein bL27 family
FORC46_RS00505	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
FORC46_RS00515	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
FORC46_RS00520	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
FORC46_RS00520	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
FORC46_RS00525	COG1192	Involved in chromosome partitioning
FORC46_RS00530	COG1475	DNA binding
FORC46_RS00540	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
FORC46_RS00545	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
FORC46_RS00550	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
FORC46_RS00560	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
FORC46_RS00565	COG0355	proton-transporting ATP synthase activity, rotational mechanism
FORC46_RS00570	COG0811	peptide transport
FORC46_RS00575	COG0848	biopolymer transport protein
FORC46_RS00590	COG2885	chlorophyll binding
FORC46_RS00600	COG1047	Peptidyl-prolyl cis-trans
FORC46_RS00605	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
FORC46_RS00610	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
FORC46_RS00615	COG0037	tRNA processing
FORC46_RS00630	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
FORC46_RS00640	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
FORC46_RS00650	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
FORC46_RS00660	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
FORC46_RS00665	COG0483	inositol monophosphate 1-phosphatase activity
FORC46_RS00670	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
FORC46_RS00695	COG0083	homoserine kinase activity
FORC46_RS00720	COG1401	restriction endodeoxyribonuclease activity
FORC46_RS00730	COG1108	ABC-type Mn2 Zn2 transport systems permease components
FORC46_RS00735	COG1121	(ABC) transporter
FORC46_RS00745	COG0840	transmembrane signaling receptor activity
FORC46_RS00755	COG0492	ferredoxin-NADP+ reductase activity
FORC46_RS00760	COG3118	belongs to the thioredoxin family
FORC46_RS00765	COG0792	nuclease activity
FORC46_RS00770	COG0460	homoserine dehydrogenase
FORC46_RS00775	COG0436	Aminotransferase
FORC46_RS00790	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
FORC46_RS00795	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
FORC46_RS00800	COG0254	rRNA binding
FORC46_RS00805	COG1385	rRNA (uridine-N3-)-methyltransferase activity
FORC46_RS00825	COG0602	queuosine metabolic process
FORC46_RS00830	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FORC46_RS00855	COG1971	Probably functions as a manganese efflux pump
FORC46_RS00870	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
FORC46_RS00900	COG1840	ABC-type Fe3 transport system, periplasmic component
FORC46_RS00915	COG4206	TonB-dependent receptor
FORC46_RS00915	COG1629	transport
FORC46_RS00920	COG0811	peptide transport
FORC46_RS00925	COG0848	biopolymer transport protein
FORC46_RS00935	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
FORC46_RS00940	COG1253	flavin adenine dinucleotide binding
FORC46_RS00950	COG2824	Alkylphosphonate utilization operon protein PhnA
FORC46_RS00955	COG0861	Integral membrane protein TerC family
FORC46_RS00960	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
FORC46_RS00965	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
FORC46_RS00965	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
FORC46_RS00975	COG0606	chelatase, subunit chli
FORC46_RS00980	COG0242	peptide deformylase activity
FORC46_RS00990	COG0544	peptidyl-prolyl cis-trans isomerase activity
FORC46_RS00995	COG0302	gtp cyclohydrolase
FORC46_RS01000	COG1157	protein secretion by the type III secretion system
FORC46_RS01005	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
FORC46_RS01010	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
FORC46_RS01015	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
FORC46_RS01015	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
FORC46_RS01045	COG1297	OPT oligopeptide transporter protein
FORC46_RS01050	COG1968	undecaprenyl-diphosphatase activity
FORC46_RS01060	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
FORC46_RS01115	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
FORC46_RS01120	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
FORC46_RS01125	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
FORC46_RS01140	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
FORC46_RS01155	COG0233	cytoplasmic translational termination
FORC46_RS01160	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
FORC46_RS01165	COG0670	Belongs to the BI1 family
FORC46_RS01170	COG0288	reversible hydration of carbon dioxide
FORC46_RS01175	COG0668	transmembrane transport
FORC46_RS01200	COG0291	Belongs to the bacterial ribosomal protein bL35 family
FORC46_RS01205	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
FORC46_RS01210	COG3290	protein histidine kinase activity
FORC46_RS01210	COG0840	transmembrane signaling receptor activity
FORC46_RS01235	COG0477	Major facilitator Superfamily
FORC46_RS01250	COG2921	Belongs to the UPF0250 family
FORC46_RS01260	COG0708	Exodeoxyribonuclease III
FORC46_RS01265	COG2194	sulfuric ester hydrolase activity
FORC46_RS01270	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
FORC46_RS01280	COG0418	dihydroorotase activity
FORC46_RS01290	COG2226	methyltransferase
FORC46_RS01295	COG0840	transmembrane signaling receptor activity
FORC46_RS01300	COG0428	transporter
FORC46_RS01305	COG0243	molybdopterin cofactor binding
FORC46_RS01325	COG0330	HflC and HflK could
FORC46_RS01335	COG1942	4-Oxalocrotonate Tautomerase
FORC46_RS01340	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
FORC46_RS01345	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
FORC46_RS01350	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
FORC46_RS01355	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC46_RS01360	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
FORC46_RS01365	COG1077	Cell shape determining protein MreB Mrl
FORC46_RS01375	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
FORC46_RS01385	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
FORC46_RS01395	COG0835	chemotaxis
FORC46_RS01400	COG0643	Histidine kinase
FORC46_RS01400	COG2198	Histidine kinase
FORC46_RS01400	COG0784	Response regulator, receiver
FORC46_RS01405	COG0835	chemotaxis
FORC46_RS01405	COG0784	Response regulator, receiver
FORC46_RS01415	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
FORC46_RS01420	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
FORC46_RS01490	COG4106	trans-aconitate 2-methyltransferase activity
FORC46_RS01495	COG2830	Protein of unknown function (DUF452)
FORC46_RS01505	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
FORC46_RS01510	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
FORC46_RS01515	COG2076	Multidrug Resistance protein
FORC46_RS01530	COG0193	aminoacyl-tRNA hydrolase activity
FORC46_RS01540	COG0019	diaminopimelate decarboxylase activity
FORC46_RS01565	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC46_RS01600	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
FORC46_RS01605	COG0251	oxidation-reduction process
FORC46_RS01610	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC46_RS01620	COG0333	Belongs to the bacterial ribosomal protein bL32 family
FORC46_RS01640	COG0450	alkyl hydroperoxide reductase
FORC46_RS01645	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FORC46_RS01650	COG1360	Flagellar Motor Protein
FORC46_RS01655	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
FORC46_RS01670	COG0477	Major facilitator Superfamily
FORC46_RS01685	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
FORC46_RS01690	COG0730	response to heat
FORC46_RS01705	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FORC46_RS01705	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC46_RS01715	COG0133	tryptophan synthase activity
FORC46_RS01730	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
FORC46_RS01730	COG1776	CheC inhibitor of MCP methylation
FORC46_RS01745	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
FORC46_RS01750	COG0745	RESPONSE REGULATOR receiver
FORC46_RS01760	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
FORC46_RS01770	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
FORC46_RS01775	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
FORC46_RS01785	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC46_RS01795	COG1538	Outer membrane efflux protein
FORC46_RS01805	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC46_RS01820	COG0828	Belongs to the bacterial ribosomal protein bS21 family
FORC46_RS01835	COG0754	glutathionylspermidine amidase activity
FORC46_RS01840	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
FORC46_RS01845	COG1666	GTP binding
FORC46_RS01860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC46_RS01865	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
FORC46_RS01870	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
FORC46_RS01875	COG0284	orotidine-5'-phosphate decarboxylase activity
FORC46_RS01880	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
FORC46_RS01885	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
FORC46_RS01890	COG2877	3-deoxy-8-phosphooctulonate synthase activity
FORC46_RS01900	COG1160	GTP binding
FORC46_RS01905	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
FORC46_RS01930	COG0469	pyruvate kinase activity
FORC46_RS01935	COG0579	oxidoreductase
FORC46_RS01940	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
FORC46_RS01960	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FORC46_RS01995	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
FORC46_RS02015	COG1053	succinate dehydrogenase
FORC46_RS02020	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC46_RS02080	COG0488	(ABC) transporter
FORC46_RS02095	COG1739	Uncharacterized protein family UPF0029
FORC46_RS02135	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
FORC46_RS02140	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
FORC46_RS02145	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
FORC46_RS02155	COG1028	Short-chain dehydrogenase reductase Sdr
FORC46_RS02165	COG1053	succinate dehydrogenase
FORC46_RS02170	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
FORC46_RS02175	COG2048	Heterodisulfide reductase, subunit B
FORC46_RS02180	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
FORC46_RS02185	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
FORC46_RS02190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
FORC46_RS02200	COG4771	TonB-dependent receptor
FORC46_RS02210	COG0840	transmembrane signaling receptor activity
FORC46_RS02220	COG0227	Belongs to the bacterial ribosomal protein bL28 family
FORC46_RS02225	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
FORC46_RS02255	COG2121	Domain of unknown function (DUF374)
FORC46_RS02270	COG0195	Participates in both transcription termination and antitermination
FORC46_RS02280	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FORC46_RS02285	COG0612	Peptidase, M16
FORC46_RS02290	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
FORC46_RS02295	COG2346	COG2346, Truncated hemoglobins
FORC46_RS02310	COG0765	amino acid transport
FORC46_RS02340	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
FORC46_RS02345	COG0267	Belongs to the bacterial ribosomal protein bL33 family
FORC46_RS02360	COG0250	Participates in transcription elongation, termination and antitermination
FORC46_RS02365	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
FORC46_RS02370	COG0081	regulation of translation
FORC46_RS02380	COG0222	ribosome binding
FORC46_RS02385	COG0085	RNA polymerase activity
FORC46_RS02390	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
FORC46_RS02395	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
FORC46_RS02400	COG0049	tRNA binding
FORC46_RS02445	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
FORC46_RS02450	COG0004	ammonium transporteR
FORC46_RS02460	COG0673	inositol 2-dehydrogenase activity
FORC46_RS02470	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
FORC46_RS02475	COG0424	maF-like protein
FORC46_RS02485	COG0542	response to heat
FORC46_RS02490	COG1937	Protein conserved in bacteria
FORC46_RS02495	COG0793	Belongs to the peptidase S41A family
FORC46_RS02500	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
FORC46_RS02505	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FORC46_RS02510	COG0047	phosphoribosylformylglycinamidine synthase activity
FORC46_RS02520	COG0204	Acyl-transferase
FORC46_RS02535	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
FORC46_RS02555	COG1677	Flagellar hook-basal body complex protein FliE
FORC46_RS02560	COG1558	bacterial-type flagellum-dependent cell motility
FORC46_RS02565	COG1815	bacterial-type flagellum-dependent cell motility
FORC46_RS02585	COG0039	L-malate dehydrogenase activity
FORC46_RS02595	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
FORC46_RS02605	COG0674	pyruvate-flavodoxin oxidoreductase activity
FORC46_RS02605	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
FORC46_RS02610	COG1013	pyruvate-flavodoxin oxidoreductase activity
FORC46_RS02630	COG0142	geranyltranstransferase activity
FORC46_RS02635	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
FORC46_RS02640	COG0442	prolyl-tRNA aminoacylation
FORC46_RS02650	COG0181	hydroxymethylbilane synthase activity
FORC46_RS02655	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
FORC46_RS02665	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
FORC46_RS02685	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
FORC46_RS02715	COG1289	transmembrane transporter activity
FORC46_RS02720	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
FORC46_RS02725	COG0492	ferredoxin-NADP+ reductase activity
FORC46_RS02740	COG0305	Participates in initiation and elongation during chromosome replication
FORC46_RS02800	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC46_RS02800	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC46_RS02805	COG1610	YqeY-like protein
FORC46_RS02810	COG0028	Belongs to the TPP enzyme family
FORC46_RS02815	COG0440	acetolactate synthase activity
FORC46_RS02825	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
FORC46_RS02830	COG0805	protein transport
FORC46_RS02840	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC46_RS02845	COG0494	nUDIX hydrolase
FORC46_RS02850	COG0527	aspartate kinase activity
FORC46_RS02865	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
FORC46_RS02870	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
FORC46_RS02885	COG0196	riboflavin kinase activity
FORC46_RS02890	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC46_RS02905	COG2860	membrane
FORC46_RS02915	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
FORC46_RS02920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC46_RS02925	COG0191	fructose-bisphosphate aldolase activity
FORC46_RS02945	COG0733	neurotransmitter:sodium symporter activity
FORC46_RS02950	COG2258	MOSC domain
FORC46_RS02965	COG1473	amidohydrolase
FORC46_RS02970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
FORC46_RS02975	COG1136	(ABC) transporter
FORC46_RS02975	COG0577	efflux transmembrane transporter activity
FORC46_RS02980	COG1538	Outer membrane efflux protein
FORC46_RS02995	COG1696	Membrane protein involved in D-alanine export
FORC46_RS03000	COG1528	Iron-storage protein
FORC46_RS03005	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
FORC46_RS03010	COG0573	inorganic phosphate transmembrane transporter activity
FORC46_RS03015	COG0581	inorganic phosphate transmembrane transporter activity
FORC46_RS03035	COG0534	Mate efflux family protein
FORC46_RS03050	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
FORC46_RS03060	COG0298	carbon dioxide binding
FORC46_RS03065	COG0409	Hydrogenase expression formation protein
FORC46_RS03070	COG0309	Hydrogenase expression formation protein (HypE)
FORC46_RS03075	COG0375	protein maturation
FORC46_RS03090	COG0557	exoribonuclease II activity
FORC46_RS03095	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
FORC46_RS03105	COG0758	DNA mediated transformation
FORC46_RS03120	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC46_RS03125	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
FORC46_RS03130	COG0563	adenylate kinase activity
FORC46_RS03135	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
FORC46_RS03140	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
FORC46_RS03145	COG0497	DNA recombination
FORC46_RS03155	COG0084	hydrolase, TatD family'
FORC46_RS03160	COG1388	LysM domain
FORC46_RS03160	COG0791	NLP P60 protein
FORC46_RS03165	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
FORC46_RS03205	COG3104	oligopeptide transport
FORC46_RS03230	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
FORC46_RS03235	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
FORC46_RS03240	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
FORC46_RS03245	COG0359	binds to the 23S rRNA
FORC46_RS03250	COG0137	argininosuccinate synthase activity
FORC46_RS03255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
FORC46_RS03260	COG0802	atpase or kinase
FORC46_RS03265	COG1137	ATPase activity
FORC46_RS03270	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
FORC46_RS03275	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
FORC46_RS03285	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
FORC46_RS03290	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
FORC46_RS03295	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
FORC46_RS03300	COG2205	protein histidine kinase activity
FORC46_RS03305	COG0556	nucleotide-excision repair
FORC46_RS03325	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
FORC46_RS03335	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
FORC46_RS03340	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
FORC46_RS03345	COG0280	phosphate acetyltransferase
FORC46_RS03370	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
FORC46_RS03375	COG0849	cell division
FORC46_RS03380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
FORC46_RS03385	COG4786	Flagellar basal body rod
FORC46_RS03390	COG4786	Flagellar basal body rod
FORC46_RS03395	COG0174	glutamine synthetase
FORC46_RS03410	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
FORC46_RS03420	COG0752	glycyl-tRNA synthetase alpha subunit
FORC46_RS03425	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
FORC46_RS03435	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FORC46_RS03435	COG1519	Transferase
FORC46_RS03440	COG0564	pseudouridine synthase activity
FORC46_RS03445	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
FORC46_RS03450	COG0228	four-way junction DNA binding
FORC46_RS03455	COG1837	Belongs to the UPF0109 family
FORC46_RS03460	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
FORC46_RS03465	COG0336	Belongs to the RNA methyltransferase TrmD family
FORC46_RS03470	COG0335	large ribosomal subunit rRNA binding
FORC46_RS03480	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
FORC46_RS03485	COG1393	Belongs to the ArsC family
FORC46_RS03495	COG0587	DNA-directed DNA polymerase activity
FORC46_RS03500	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
FORC46_RS03515	COG2890	protein-(glutamine-N5) methyltransferase activity
FORC46_RS03520	COG0501	Belongs to the peptidase M48B family
FORC46_RS03530	COG2856	Zn peptidase
FORC46_RS03570	COG0521	Mo-molybdopterin cofactor biosynthetic process
FORC46_RS03575	COG0598	Magnesium transport protein CorA
FORC46_RS03605	COG3842	ATPase activity
FORC46_RS03685	COG1420	regulation of RNA biosynthetic process
FORC46_RS03735	COG0436	Aminotransferase
FORC46_RS03740	COG1045	serine acetyltransferase
FORC46_RS03745	COG1166	arginine decarboxylase activity
FORC46_RS03750	COG0124	histidyl-tRNA synthetase
FORC46_RS03755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
FORC46_RS03760	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
FORC46_RS03765	COG0163	prenyltransferase activity
FORC46_RS03775	COG1464	Belongs to the NlpA lipoprotein family
FORC46_RS03780	COG1464	Belongs to the NlpA lipoprotein family
FORC46_RS03785	COG1464	Belongs to the NlpA lipoprotein family
FORC46_RS03790	COG2011	ABC-type metal ion transport system permease component
FORC46_RS03795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FORC46_RS03810	COG0210	DNA helicase
FORC46_RS03820	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
FORC46_RS03825	COG0243	molybdopterin cofactor binding
FORC46_RS03830	COG0437	4 iron, 4 sulfur cluster binding
FORC46_RS03835	COG0348	domain, Protein
FORC46_RS03840	COG3043	anaerobic respiration
FORC46_RS03875	COG0788	formyltetrahydrofolate deformylase activity
FORC46_RS03880	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
FORC46_RS03890	COG0642	Histidine kinase
FORC46_RS03915	COG1181	Belongs to the D-alanine--D-alanine ligase family
FORC46_RS03920	COG0632	four-way junction helicase activity
FORC46_RS03930	COG0728	peptidoglycan biosynthetic process
FORC46_RS03935	COG0215	cysteine-tRNA ligase activity
FORC46_RS03940	COG1132	(ABC) transporter
FORC46_RS03945	COG0167	dihydroorotate dehydrogenase activity
FORC46_RS03950	COG0612	Peptidase, M16
FORC46_RS03960	COG1028	Short-chain dehydrogenase reductase Sdr
FORC46_RS03975	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
FORC46_RS03980	COG1663	tetraacyldisaccharide 4'-kinase activity
FORC46_RS03985	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
FORC46_RS03990	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
FORC46_RS04000	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC46_RS04015	COG1338	Plays a role in the flagellum-specific transport system
FORC46_RS04020	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
FORC46_RS04050	COG0101	tRNA pseudouridine synthase activity
FORC46_RS04055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
FORC46_RS04070	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
FORC46_RS04075	COG1757	Na H antiporter
FORC46_RS04080	COG4221	oxidoreductase activity
FORC46_RS04090	COG1049	propionate catabolic process, 2-methylcitrate cycle
FORC46_RS04095	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
FORC46_RS04105	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC46_RS04105	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC46_RS04115	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
FORC46_RS04140	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC46_RS04145	COG1408	metallophosphoesterase
FORC46_RS04150	COG0688	phosphatidylethanolamine metabolic process
FORC46_RS04180	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
FORC46_RS04190	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
FORC46_RS04195	COG0681	Belongs to the peptidase S26 family
FORC46_RS04200	COG0303	'Molybdopterin
FORC46_RS04205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
FORC46_RS04220	COG0512	Glutamine amidotransferase of anthranilate synthase
FORC46_RS04220	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
FORC46_RS04225	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
FORC46_RS04230	COG0582	viral genome integration into host DNA
FORC46_RS04235	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
FORC46_RS04240	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
FORC46_RS04285	COG2404	hydrolase activity, acting on ester bonds
FORC46_RS04290	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
FORC46_RS04295	COG1959	2 iron, 2 sulfur cluster binding
FORC46_RS04300	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
FORC46_RS04305	COG1674	ftsk spoiiie
FORC46_RS04305	COG1196	nuclear chromosome segregation
FORC46_RS04310	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
FORC46_RS04330	COG5002	protein histidine kinase activity
FORC46_RS04340	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
FORC46_RS04350	COG0539	negative regulation of cytoplasmic translation
FORC46_RS04350	COG1185	polyribonucleotide nucleotidyltransferase activity
FORC46_RS04360	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
FORC46_RS04365	COG0072	phenylalanine-tRNA ligase activity
FORC46_RS04365	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
FORC46_RS04370	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
FORC46_RS04375	COG0537	adenosine 5'-monophosphoramidase activity
FORC46_RS04390	COG0765	amino acid transport
FORC46_RS04400	COG1115	amino acid carrier protein
FORC46_RS04405	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
FORC46_RS04410	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
FORC46_RS04435	COG1999	signal sequence binding
FORC46_RS04440	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
FORC46_RS04445	COG0776	regulation of translation
FORC46_RS04465	COG1966	Carbon starvation protein
FORC46_RS04470	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
FORC46_RS04475	COG0765	amino acid transport
FORC46_RS04480	COG0765	amino acid transport
FORC46_RS04485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC46_RS04490	COG1126	abc transporter atp-binding protein
FORC46_RS04495	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
FORC46_RS04500	COG2201	protein-glutamate methylesterase activity
FORC46_RS04515	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
FORC46_RS04525	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
FORC46_RS04530	COG0012	GTP binding
FORC46_RS04535	COG0165	Argininosuccinate lyase
FORC46_RS04540	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
FORC46_RS04545	COG0511	ligase activity, forming carbon-carbon bonds
FORC46_RS04545	COG5016	pyruvate
FORC46_RS04550	COG0733	neurotransmitter:sodium symporter activity
FORC46_RS04555	COG0733	neurotransmitter:sodium symporter activity
FORC46_RS04655	COG0765	amino acid transport
FORC46_RS04665	COG0653	protein targeting
FORC46_RS04670	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
FORC46_RS04680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
FORC46_RS04695	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
FORC46_RS04710	COG0840	transmembrane signaling receptor activity
FORC46_RS04715	COG0138	bifunctional purine biosynthesis protein purh
FORC46_RS04720	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
FORC46_RS04725	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
FORC46_RS04740	COG0706	membrane insertase activity
FORC46_RS04745	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
FORC46_RS04750	COG0594	ribonuclease P activity
FORC46_RS04755	COG0230	Belongs to the bacterial ribosomal protein bL34 family
FORC46_RS04770	COG0824	Thioesterase
FORC46_RS04800	COG0500	methyltransferase
FORC46_RS04820	COG2195	Cleaves the N-terminal amino acid of tripeptides
FORC46_RS04825	COG0477	Major facilitator Superfamily
FORC46_RS04830	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
FORC46_RS04840	COG3022	response to hydroperoxide
FORC46_RS04845	COG1473	amidohydrolase
FORC46_RS04850	COG2807	transmembrane transport
FORC46_RS04875	COG0247	lactate metabolic process
FORC46_RS04875	COG2181	nitrate reductase activity
FORC46_RS04880	COG0635	Involved in the biosynthesis of porphyrin-containing compound
FORC46_RS04890	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
FORC46_RS04895	COG0113	porphobilinogen synthase activity
FORC46_RS04900	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
FORC46_RS04905	COG0357	Ribosomal RNA small subunit methyltransferase G
FORC46_RS04915	COG2855	membrane
FORC46_RS04920	COG0583	DNA-binding transcription factor activity
FORC46_RS04925	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
FORC46_RS04945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC46_RS04950	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
FORC46_RS04960	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
FORC46_RS04970	COG0343	queuine tRNA-ribosyltransferase activity
FORC46_RS04990	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
FORC46_RS04990	COG1333	cytochrome c biogenesis protein
FORC46_RS05015	COG0683	leucine binding
FORC46_RS05040	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
FORC46_RS05045	COG2204	response regulator
FORC46_RS05060	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
FORC46_RS05075	COG0481	GTPase activity
FORC46_RS05100	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
FORC46_RS05110	COG0439	Biotin carboxylase
FORC46_RS05115	COG0772	Belongs to the SEDS family
FORC46_RS05120	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
FORC46_RS05145	COG0352	thiamine-phosphate diphosphorylase activity
FORC46_RS05150	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FORC46_RS05155	COG2022	thiamine diphosphate biosynthetic process
FORC46_RS05170	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
FORC46_RS05185	COG1193	negative regulation of DNA recombination
FORC46_RS05215	COG0516	GMP reductase activity
FORC46_RS05215	COG0517	IMP dehydrogenase activity
FORC46_RS05235	COG1058	Belongs to the CinA family
FORC46_RS05235	COG1546	Belongs to the CinA family
FORC46_RS05245	COG0778	Nitroreductase
FORC46_RS05250	COG0778	Nitroreductase
FORC46_RS05260	COG0750	zinc metalloprotease
FORC46_RS05265	COG2990	Protein conserved in bacteria
FORC46_RS05270	COG0360	Binds together with S18 to 16S ribosomal RNA
FORC46_RS05275	COG0629	single-stranded DNA binding
FORC46_RS05280	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
FORC46_RS05285	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
FORC46_RS05295	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
FORC46_RS05300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
FORC46_RS05325	COG0352	thiamine-phosphate diphosphorylase activity
FORC46_RS05345	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
FORC46_RS05355	COG0739	heme binding
FORC46_RS05360	COG0285	dihydrofolate synthase activity
FORC46_RS05375	COG0495	leucyl-tRNA aminoacylation
FORC46_RS05380	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC46_RS05385	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
FORC46_RS05390	COG1862	Preprotein translocase
FORC46_RS05395	COG0815	Transfers the fatty acyl group on membrane lipoproteins
FORC46_RS05400	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
FORC46_RS05405	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
FORC46_RS05425	COG0210	DNA helicase
FORC46_RS05430	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
FORC46_RS05440	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
FORC46_RS05445	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
FORC46_RS05455	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
FORC46_RS05460	COG0542	response to heat
FORC46_RS05465	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
FORC46_RS05475	COG2095	MarC family integral membrane protein
FORC46_RS05480	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
FORC46_RS05485	COG2833	Protein of unknown function (DUF455)
FORC46_RS05490	COG1183	phosphatidylcholine synthase activity
FORC46_RS05500	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
FORC46_RS05510	COG0745	RESPONSE REGULATOR receiver
FORC46_RS05520	COG1086	Polysaccharide biosynthesis protein
FORC46_RS05525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FORC46_RS05535	COG0110	maltose O-acetyltransferase activity
FORC46_RS05540	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
FORC46_RS05545	COG0438	transferase activity, transferring glycosyl groups
FORC46_RS05550	COG1287	oligosaccharyl transferase activity
FORC46_RS05555	COG0438	transferase activity, transferring glycosyl groups
FORC46_RS05560	COG1215	transferase activity, transferring glycosyl groups
FORC46_RS05565	COG0438	transferase activity, transferring glycosyl groups
FORC46_RS05570	COG1132	(ABC) transporter
FORC46_RS05575	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
FORC46_RS05585	COG0859	PFAM glycosyl transferase family 9
FORC46_RS05590	COG1560	Kdo2-lipid A biosynthetic process
FORC46_RS05600	COG1442	glycosyl transferase family 8
FORC46_RS05600	COG1216	Glycosyl transferase, family 2
FORC46_RS05610	COG1442	glycosyl transferase family 8
FORC46_RS05610	COG1216	Glycosyl transferase, family 2
FORC46_RS05620	COG2089	acid synthase
FORC46_RS05635	COG0110	maltose O-acetyltransferase activity
FORC46_RS05640	COG1216	Glycosyl transferase, family 2
FORC46_RS05665	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC46_RS05680	COG2217	Heavy metal translocating P-type atpase
FORC46_RS05685	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
FORC46_RS05690	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
FORC46_RS05700	COG2217	Heavy metal translocating P-type atpase
FORC46_RS05720	COG3610	response to peptide
FORC46_RS05730	COG0039	L-malate dehydrogenase activity
FORC46_RS05735	COG0586	Pfam SNARE associated Golgi protein
FORC46_RS05750	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
FORC46_RS05755	COG0217	transcriptional regulatory protein
FORC46_RS05770	COG0018	arginyl-trna synthetase
FORC46_RS05775	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
FORC46_RS05780	COG0194	GDP metabolic process
FORC46_RS05790	COG1684	flagellar biosynthetic protein fliR
FORC46_RS05800	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
FORC46_RS05805	COG0052	Belongs to the universal ribosomal protein uS2 family
FORC46_RS05810	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
FORC46_RS05820	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
FORC46_RS05825	COG0723	plastoquinol--plastocyanin reductase activity
FORC46_RS05830	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
FORC46_RS05835	COG0445	tRNA wobble uridine modification
FORC46_RS05855	COG1301	dicarboxylic acid transport
FORC46_RS05870	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
FORC46_RS05875	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
FORC46_RS05880	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
FORC46_RS05885	COG1854	S-ribosylhomocysteine lyase activity
FORC46_RS05905	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
FORC46_RS05915	COG0356	it plays a direct role in the translocation of protons across the membrane
FORC46_RS05920	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
FORC46_RS05925	COG0552	protein localization to endoplasmic reticulum
FORC46_RS05940	COG1418	mRNA catabolic process
FORC46_RS05955	COG1295	ribonuclease BN
FORC46_RS05960	COG0277	FAD linked oxidase domain protein
FORC46_RS05970	COG0739	heme binding
FORC46_RS05995	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
FORC46_RS06000	COG0459	protein refolding
FORC46_RS06005	COG0642	Histidine kinase
FORC46_RS06010	COG0745	RESPONSE REGULATOR receiver
FORC46_RS06030	COG0642	Histidine kinase
FORC46_RS06035	COG0745	RESPONSE REGULATOR receiver
FORC46_RS06040	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
FORC46_RS06045	COG0484	heat shock protein binding
FORC46_RS06050	COG0789	Transcriptional regulator
FORC46_RS06055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
FORC46_RS06055	COG0475	glutathione-regulated potassium exporter activity
FORC46_RS06070	COG0751	glycine-tRNA ligase activity
FORC46_RS06075	COG0739	heme binding
FORC46_RS06085	COG0248	Ppx GppA phosphatase
FORC46_RS06090	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
FORC46_RS06095	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
FORC46_RS06105	COG2814	Major facilitator Superfamily
FORC46_RS06115	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
FORC46_RS06120	COG0731	radical SAM domain protein
FORC46_RS06130	COG0322	excinuclease ABC activity
FORC46_RS06140	COG0518	GMP synthase (glutamine-hydrolyzing) activity
FORC46_RS06140	COG0519	Catalyzes the synthesis of GMP from XMP
FORC46_RS06165	COG1185	polyribonucleotide nucleotidyltransferase activity
FORC46_RS06175	COG1942	4-Oxalocrotonate Tautomerase
FORC46_RS06190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
FORC46_RS06195	COG4773	Receptor
FORC46_RS06200	COG0484	heat shock protein binding
FORC46_RS06205	COG0745	RESPONSE REGULATOR receiver
FORC46_RS06210	COG0642	Histidine kinase
FORC46_RS06220	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
FORC46_RS06225	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
FORC46_RS06230	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
FORC46_RS06235	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
FORC46_RS06240	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
FORC46_RS06240	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
FORC46_RS06255	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
FORC46_RS06260	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
FORC46_RS06265	COG1758	RNA polymerase activity
FORC46_RS06270	COG0528	UMP kinase activity
FORC46_RS06285	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
FORC46_RS06290	COG0220	tRNA (guanine-N7-)-methyltransferase activity
FORC46_RS06300	COG0564	pseudouridine synthase activity
FORC46_RS06305	COG0772	Belongs to the SEDS family
FORC46_RS06320	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
FORC46_RS06325	COG0569	domain protein
FORC46_RS06330	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FORC46_RS06335	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
FORC46_RS06340	COG0280	phosphate acetyltransferase
FORC46_RS06340	COG0281	malic enzyme
FORC46_RS06345	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
FORC46_RS06355	COG0439	Biotin carboxylase
FORC46_RS06360	COG0511	ligase activity, forming carbon-carbon bonds
FORC46_RS06370	COG1086	Polysaccharide biosynthesis protein
FORC46_RS06375	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
FORC46_RS06380	COG4310	Domain of unknown function (DUF2172)
FORC46_RS06415	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
FORC46_RS06455	COG1083	cytidylyl-transferase
FORC46_RS06460	COG3980	spore coat polysaccharide biosynthesis protein
FORC46_RS06465	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
FORC46_RS06470	COG0107	imidazoleglycerol-phosphate synthase activity
FORC46_RS06475	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
FORC46_RS06485	COG2089	acid synthase
FORC46_RS06525	COG2165	general secretion pathway protein
FORC46_RS06530	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
FORC46_RS06540	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
FORC46_RS06545	COG0575	Belongs to the CDS family
FORC46_RS06555	COG1293	RNA-binding protein homologous to eukaryotic snRNP
FORC46_RS06560	COG0746	molybdenum cofactor guanylyltransferase activity
FORC46_RS06565	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
FORC46_RS06570	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC46_RS06575	COG4605	iron ion homeostasis
FORC46_RS06580	COG4604	ABC transporter, ATP-binding protein
FORC46_RS06585	COG4607	ABC-type enterochelin transport system periplasmic component
FORC46_RS06610	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
FORC46_RS06615	COG3005	denitrification pathway
FORC46_RS06620	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
FORC46_RS06635	COG2255	four-way junction helicase activity
FORC46_RS06640	COG0628	permease
FORC46_RS06645	COG0114	fumarate hydratase activity
FORC46_RS06655	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
FORC46_RS06665	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
FORC46_RS06670	COG2252	PERMEase
FORC46_RS06680	COG2853	Lipoprotein
FORC46_RS06700	COG2814	Major facilitator Superfamily
FORC46_RS06720	COG3276	selenocysteine insertion sequence binding
FORC46_RS06735	COG0716	FMN binding
FORC46_RS06750	COG0753	catalase activity
FORC46_RS06760	COG2964	Protein conserved in bacteria
FORC46_RS06765	COG0251	oxidation-reduction process
FORC46_RS06770	COG3069	C4-dicarboxylate transmembrane transporter activity
FORC46_RS06790	COG1918	ferrous iron import across plasma membrane
FORC46_RS06795	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
FORC46_RS06800	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
FORC46_RS06805	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
FORC46_RS06810	COG0149	triose-phosphate isomerase activity
FORC46_RS06815	COG0126	phosphoglycerate kinase activity
FORC46_RS06820	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
FORC46_RS06845	COG1580	Controls the rotational direction of flagella during chemotaxis
FORC46_RS06860	COG2124	cytochrome p450
FORC46_RS06880	COG0529	Catalyzes the synthesis of activated sulfate
FORC46_RS06885	COG1213	nucleotidyl transferase
FORC46_RS06890	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
FORC46_RS06895	COG0574	Belongs to the PEP-utilizing enzyme family
FORC46_RS06895	COG3848	Pyruvate phosphate dikinase
FORC46_RS06900	COG2226	methyltransferase
FORC46_RS06915	COG1442	glycosyl transferase family 8
FORC46_RS06915	COG1216	Glycosyl transferase, family 2
FORC46_RS06925	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
FORC46_RS06945	COG3562	capsule polysaccharide
FORC46_RS06950	COG0517	IMP dehydrogenase activity
FORC46_RS06950	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
FORC46_RS07005	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
FORC46_RS07015	COG0175	sulfate reduction
FORC46_RS07020	COG2895	sulfate adenylyltransferase (ATP) activity
FORC46_RS07025	COG3273	potassium ion transport
FORC46_RS07025	COG0471	metal ion transport
FORC46_RS07030	COG0529	Catalyzes the synthesis of activated sulfate
FORC46_RS07040	COG1442	glycosyl transferase family 8
FORC46_RS07040	COG1216	Glycosyl transferase, family 2
FORC46_RS07055	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
FORC46_RS07085	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
FORC46_RS07120	COG3951	Flagellar rod assembly protein muramidase FlgJ
FORC46_RS07145	COG0730	response to heat
FORC46_RS07150	COG1459	type II secretion system
FORC46_RS07185	COG0546	phosphoglycolate phosphatase activity
FORC46_RS07195	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
FORC46_RS07200	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
FORC46_RS07205	COG0210	DNA helicase
FORC46_RS07210	COG2887	Belongs to the helicase family. UvrD subfamily
FORC46_RS07255	COG0745	RESPONSE REGULATOR receiver
FORC46_RS07270	COG0505	Belongs to the CarA family
FORC46_RS07290	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
FORC46_RS07305	COG0425	Belongs to the sulfur carrier protein TusA family
FORC46_RS07310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
FORC46_RS07340	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
FORC46_RS07350	COG0437	4 iron, 4 sulfur cluster binding
FORC46_RS07385	COG0314	molybdopterin synthase activity
FORC46_RS07390	COG0303	'Molybdopterin
FORC46_RS07395	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
FORC46_RS07405	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
FORC46_RS07415	COG3069	C4-dicarboxylate transmembrane transporter activity
FORC46_RS07420	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
FORC46_RS07430	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
FORC46_RS07435	COG2992	FlgJ-related protein
FORC46_RS07445	COG0783	Belongs to the Dps family
FORC46_RS07450	COG0166	Belongs to the GPI family
FORC46_RS07460	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
FORC46_RS07465	COG3839	Belongs to the ABC transporter superfamily
FORC46_RS07470	COG4662	Binding-protein-dependent transport system inner membrane component
FORC46_RS07475	COG2998	abc-type tungstate transport system, permease component
FORC46_RS07480	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
FORC46_RS07485	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
FORC46_RS07490	COG1984	allophanate hydrolase subunit 2
FORC46_RS07500	COG2249	NAD(P)H dehydrogenase (quinone) activity
FORC46_RS07505	COG1733	regulation of RNA biosynthetic process
FORC46_RS07515	COG1064	alcohol dehydrogenase
FORC46_RS07535	COG3177	Filamentation induced by cAMP protein fic
FORC46_RS07560	COG0640	Transcriptional regulator
FORC46_RS07590	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FORC46_RS07595	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
FORC46_RS07605	COG0839	Belongs to the complex I subunit 6 family
FORC46_RS07640	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FORC46_RS07645	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FORC46_RS07650	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
FORC46_RS07665	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
FORC46_RS07670	COG0601	transmembrane transport
FORC46_RS07705	COG4615	Cyclic peptide transporter
FORC46_RS07715	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
FORC46_RS07720	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
FORC46_RS07725	COG0257	Belongs to the bacterial ribosomal protein bL36 family
FORC46_RS07730	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
FORC46_RS07735	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
FORC46_RS07740	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
FORC46_RS07745	COG0202	RNA polymerase activity
FORC46_RS07750	COG0203	ribosomal protein L17
FORC46_RS07755	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
FORC46_RS07765	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
FORC46_RS07765	COG0131	Imidazoleglycerol-phosphate dehydratase
FORC46_RS07775	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
FORC46_RS07790	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
FORC46_RS07790	COG0140	phosphoribosyl-ATP diphosphatase activity
FORC46_RS07795	COG2171	N-acyltransferase activity
FORC46_RS07800	COG0489	protein tyrosine kinase activity
FORC46_RS07805	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
FORC46_RS07805	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
FORC46_RS07810	COG0745	RESPONSE REGULATOR receiver
FORC46_RS07815	COG2046	Belongs to the sulfate adenylyltransferase family
FORC46_RS07820	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
FORC46_RS07825	COG0268	Binds directly to 16S ribosomal RNA
FORC46_RS07830	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
FORC46_RS07835	COG0748	coenzyme F420 binding
FORC46_RS07840	COG4771	TonB-dependent receptor
FORC46_RS07845	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
FORC46_RS07850	COG1120	ATPase activity
FORC46_RS07855	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
FORC46_RS07865	COG0477	Major facilitator Superfamily
FORC46_RS07870	COG1194	a g-specific adenine glycosylase
FORC46_RS07900	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC46_RS07900	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
FORC46_RS07910	COG1760	l-serine dehydratase
FORC46_RS07915	COG0814	amino acid
FORC46_RS07930	COG0811	peptide transport
FORC46_RS07935	COG0848	biopolymer transport protein
FORC46_RS07960	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
FORC46_RS07970	COG0328	RNA-DNA hybrid ribonuclease activity
FORC46_RS07980	COG0358	DNA primase activity
FORC46_RS07995	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
FORC46_RS08000	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
FORC46_RS08015	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
FORC46_RS08020	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
FORC46_RS08025	COG1127	ABC transporter
FORC46_RS08035	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
FORC46_RS08035	COG3218	ABC-type transport auxiliary lipoprotein component
FORC46_RS08045	COG0024	Methionine aminopeptidase
FORC46_RS08050	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
FORC46_RS08055	COG0791	NLP P60 protein
FORC46_RS08065	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
FORC46_RS08080	COG0672	)-iron permease
FORC46_RS08105	COG1136	(ABC) transporter
FORC46_RS08155	COG1793	dna ligase
FORC46_RS08170	COG0148	phosphopyruvate hydratase activity
FORC46_RS08175	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
FORC46_RS08180	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
FORC46_RS08185	COG1987	bacterial-type flagellum assembly
FORC46_RS08200	COG1218	3'(2'),5'-bisphosphate nucleotidase
FORC46_RS08205	COG0372	Belongs to the citrate synthase family
FORC46_RS08215	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
FORC46_RS08220	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC46_RS08230	COG2936	dipeptidyl-peptidase activity
FORC46_RS08240	COG0201	protein transport
FORC46_RS08245	COG0200	Binds to the 23S rRNA
FORC46_RS08250	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
FORC46_RS08255	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
FORC46_RS08260	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
FORC46_RS08265	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
FORC46_RS08270	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
FORC46_RS08275	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
FORC46_RS08280	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
FORC46_RS08285	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
FORC46_RS08290	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
FORC46_RS08295	COG0255	Belongs to the universal ribosomal protein uL29 family
FORC46_RS08300	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
FORC46_RS08305	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
FORC46_RS08310	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
FORC46_RS08315	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
FORC46_RS08325	COG0089	rRNA binding
FORC46_RS08330	COG0088	Forms part of the polypeptide exit tunnel
FORC46_RS08335	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
FORC46_RS08340	COG0051	transcription antitermination factor activity, RNA binding
FORC46_RS08345	COG1187	pseudouridine synthase activity
FORC46_RS08350	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
FORC46_RS08365	COG0820	rRNA (adenine-C2-)-methyltransferase activity
FORC46_RS08410	COG0473	3-isopropylmalate dehydrogenase activity
FORC46_RS08415	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
FORC46_RS08430	COG0673	inositol 2-dehydrogenase activity
FORC46_RS08460	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
FORC46_RS08465	COG1749	Flagellar hook protein flgE
FORC46_RS08470	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
FORC46_RS08590	COG1598	PFAM Uncharacterised protein family UPF0150
FORC46_RS08615	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
FORC46_RS08640	COG3646	Phage regulatory protein
FORC46_RS08650	COG0629	single-stranded DNA binding
FORC46_RS08675	COG3736	Type IV secretory pathway, component VirB8
FORC46_RS08680	COG3504	Conjugal transfer protein
FORC46_RS08720	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
FORC46_RS08850	COG1192	Involved in chromosome partitioning
FORC46_RS08905	COG4962	Type ii secretion system protein e
FORC46_RS08915	COG5268	conjugation
FORC46_RS08940	COG3646	Phage regulatory protein