locus-tag	class	description
IOO21_RS00010	COG0592	DNA-directed DNA polymerase activity
IOO21_RS00015	COG0187	DNA topoisomerase II activity
IOO21_RS00030	COG2056	Na+-H+ antiporter family
IOO21_RS00035	COG0070	glutamate synthase
IOO21_RS00035	COG0069	glutamate synthase activity
IOO21_RS00035	COG0067	glutamate synthase
IOO21_RS00045	COG0493	'glutamate synthase
IOO21_RS00050	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
IOO21_RS00060	COG1592	Rubrerythrin
IOO21_RS00065	COG0129	dihydroxy-acid dehydratase activity
IOO21_RS00080	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
IOO21_RS00095	COG0840	transmembrane signaling receptor activity
IOO21_RS00100	COG1858	cytochrome C peroxidase
IOO21_RS00105	COG0179	Fumarylacetoacetate (FAA) hydrolase
IOO21_RS00110	COG0564	pseudouridine synthase activity
IOO21_RS00115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
IOO21_RS00120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IOO21_RS00135	COG0504	CTP synthase activity
IOO21_RS00145	COG0252	asparaginase activity
IOO21_RS00200	COG2814	Major facilitator Superfamily
IOO21_RS00220	COG1217	gtp-binding protein TYPA
IOO21_RS00235	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
IOO21_RS00265	COG0471	metal ion transport
IOO21_RS00275	COG0471	metal ion transport
IOO21_RS00280	COG0471	metal ion transport
IOO21_RS00285	COG0482	sulfurtransferase activity
IOO21_RS00315	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IOO21_RS00315	COG1776	CheC inhibitor of MCP methylation
IOO21_RS00320	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IOO21_RS00325	COG1191	sigma factor activity
IOO21_RS00335	COG0455	bacterial-type flagellum organization
IOO21_RS00340	COG1419	protein localization to endoplasmic reticulum
IOO21_RS00345	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
IOO21_RS00350	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
IOO21_RS00355	COG0402	S-adenosylhomocysteine deaminase activity
IOO21_RS00360	COG0616	signal peptide processing
IOO21_RS00385	COG1139	Iron-sulfur cluster binding protein
IOO21_RS00390	COG0247	lactate metabolic process
IOO21_RS00405	COG3021	interspecies interaction between organisms
IOO21_RS00420	COG1271	oxidase subunit
IOO21_RS00425	COG1294	oxidase, subunit
IOO21_RS00430	COG1794	racemase activity, acting on amino acids and derivatives
IOO21_RS00435	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
IOO21_RS00440	COG1027	Aspartate ammonia-lyase
IOO21_RS00445	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IOO21_RS00475	COG0261	This protein binds to 23S rRNA in the presence of protein L20
IOO21_RS00480	COG0211	Belongs to the bacterial ribosomal protein bL27 family
IOO21_RS00485	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
IOO21_RS00495	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
IOO21_RS00500	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
IOO21_RS00500	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
IOO21_RS00505	COG1192	Involved in chromosome partitioning
IOO21_RS00510	COG1475	DNA binding
IOO21_RS00520	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
IOO21_RS00525	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
IOO21_RS00530	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
IOO21_RS00535	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
IOO21_RS00540	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
IOO21_RS00545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
IOO21_RS00550	COG0811	peptide transport
IOO21_RS00555	COG0848	biopolymer transport protein
IOO21_RS00570	COG2885	chlorophyll binding
IOO21_RS00580	COG1047	Peptidyl-prolyl cis-trans
IOO21_RS00585	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
IOO21_RS00590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
IOO21_RS00595	COG0037	tRNA processing
IOO21_RS00610	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
IOO21_RS00620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
IOO21_RS00630	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
IOO21_RS00640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
IOO21_RS00650	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
IOO21_RS00675	COG0083	homoserine kinase activity
IOO21_RS00685	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
IOO21_RS00695	COG0779	Required for maturation of 30S ribosomal subunits
IOO21_RS00700	COG1401	restriction endodeoxyribonuclease activity
IOO21_RS00710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
IOO21_RS00715	COG1121	(ABC) transporter
IOO21_RS00725	COG0840	transmembrane signaling receptor activity
IOO21_RS00735	COG0492	ferredoxin-NADP+ reductase activity
IOO21_RS00740	COG3118	belongs to the thioredoxin family
IOO21_RS00745	COG0792	nuclease activity
IOO21_RS00750	COG0460	homoserine dehydrogenase
IOO21_RS00755	COG0436	Aminotransferase
IOO21_RS00770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
IOO21_RS00775	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
IOO21_RS00780	COG0254	rRNA binding
IOO21_RS00785	COG1385	rRNA (uridine-N3-)-methyltransferase activity
IOO21_RS00805	COG0602	queuosine metabolic process
IOO21_RS00810	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
IOO21_RS00830	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
IOO21_RS00835	COG1971	Probably functions as a manganese efflux pump
IOO21_RS00850	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
IOO21_RS00865	COG3842	ATPase activity
IOO21_RS00875	COG1840	ABC-type Fe3 transport system, periplasmic component
IOO21_RS00885	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
IOO21_RS00890	COG1253	flavin adenine dinucleotide binding
IOO21_RS00900	COG2824	Alkylphosphonate utilization operon protein PhnA
IOO21_RS00905	COG0861	Integral membrane protein TerC family
IOO21_RS00910	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
IOO21_RS00915	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
IOO21_RS00915	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
IOO21_RS00925	COG0606	chelatase, subunit chli
IOO21_RS00930	COG0242	peptide deformylase activity
IOO21_RS00940	COG0544	peptidyl-prolyl cis-trans isomerase activity
IOO21_RS00950	COG1157	protein secretion by the type III secretion system
IOO21_RS00955	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
IOO21_RS00960	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
IOO21_RS00965	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
IOO21_RS00965	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
IOO21_RS00990	COG2851	Citrate transporter
IOO21_RS00995	COG1297	OPT oligopeptide transporter protein
IOO21_RS01000	COG1968	undecaprenyl-diphosphatase activity
IOO21_RS01005	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
IOO21_RS01010	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
IOO21_RS01070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
IOO21_RS01075	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
IOO21_RS01090	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
IOO21_RS01100	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
IOO21_RS01105	COG0233	cytoplasmic translational termination
IOO21_RS01110	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
IOO21_RS01115	COG0670	Belongs to the BI1 family
IOO21_RS01120	COG0288	reversible hydration of carbon dioxide
IOO21_RS01125	COG0668	transmembrane transport
IOO21_RS01140	COG2703	oxygen carrier activity
IOO21_RS01150	COG0291	Belongs to the bacterial ribosomal protein bL35 family
IOO21_RS01155	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
IOO21_RS01160	COG3290	protein histidine kinase activity
IOO21_RS01160	COG0840	transmembrane signaling receptor activity
IOO21_RS01185	COG0477	Major facilitator Superfamily
IOO21_RS01195	COG0315	cyclic pyranopterin monophosphate synthase activity
IOO21_RS01200	COG2921	Belongs to the UPF0250 family
IOO21_RS01210	COG0708	Exodeoxyribonuclease III
IOO21_RS01215	COG2194	sulfuric ester hydrolase activity
IOO21_RS01220	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
IOO21_RS01230	COG0418	dihydroorotase activity
IOO21_RS01240	COG2226	methyltransferase
IOO21_RS01245	COG0840	transmembrane signaling receptor activity
IOO21_RS01250	COG0428	transporter
IOO21_RS01255	COG0243	molybdopterin cofactor binding
IOO21_RS01275	COG0330	HflC and HflK could
IOO21_RS01285	COG1942	4-Oxalocrotonate Tautomerase
IOO21_RS01290	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
IOO21_RS01295	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
IOO21_RS01300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
IOO21_RS01305	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IOO21_RS01310	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
IOO21_RS01315	COG1077	Cell shape determining protein MreB Mrl
IOO21_RS01325	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
IOO21_RS01335	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
IOO21_RS01345	COG0835	chemotaxis
IOO21_RS01350	COG0784	Response regulator, receiver
IOO21_RS01350	COG0643	Histidine kinase
IOO21_RS01350	COG2198	Histidine kinase
IOO21_RS01355	COG0784	Response regulator, receiver
IOO21_RS01355	COG0835	chemotaxis
IOO21_RS01365	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
IOO21_RS01370	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
IOO21_RS01385	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
IOO21_RS01395	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
IOO21_RS01400	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
IOO21_RS01405	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
IOO21_RS01410	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
IOO21_RS01445	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
IOO21_RS01450	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
IOO21_RS01455	COG2076	Multidrug Resistance protein
IOO21_RS01465	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
IOO21_RS01470	COG0193	aminoacyl-tRNA hydrolase activity
IOO21_RS01480	COG0019	diaminopimelate decarboxylase activity
IOO21_RS01495	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
IOO21_RS01505	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IOO21_RS01515	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
IOO21_RS01530	COG2226	methyltransferase
IOO21_RS01535	COG1570	exodeoxyribonuclease VII activity
IOO21_RS01540	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
IOO21_RS01545	COG0251	oxidation-reduction process
IOO21_RS01550	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IOO21_RS01555	COG0416	fatty acid biosynthetic process
IOO21_RS01560	COG0333	Belongs to the bacterial ribosomal protein bL32 family
IOO21_RS01570	COG0105	UTP biosynthetic process
IOO21_RS01580	COG0450	alkyl hydroperoxide reductase
IOO21_RS01585	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IOO21_RS01590	COG1360	Flagellar Motor Protein
IOO21_RS01595	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
IOO21_RS01605	COG0477	Major facilitator Superfamily
IOO21_RS01615	COG1238	metal cluster binding
IOO21_RS01620	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
IOO21_RS01625	COG0730	response to heat
IOO21_RS01640	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IOO21_RS01640	COG0512	Glutamine amidotransferase of anthranilate synthase
IOO21_RS01650	COG0133	tryptophan synthase activity
IOO21_RS01655	COG0159	tryptophan synthase activity
IOO21_RS01665	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
IOO21_RS01665	COG1776	CheC inhibitor of MCP methylation
IOO21_RS01680	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
IOO21_RS01685	COG0745	RESPONSE REGULATOR receiver
IOO21_RS01695	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
IOO21_RS01705	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
IOO21_RS01710	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
IOO21_RS01715	COG1981	membrane
IOO21_RS01720	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IOO21_RS01730	COG1538	Outer membrane efflux protein
IOO21_RS01740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOO21_RS01755	COG0828	Belongs to the bacterial ribosomal protein bS21 family
IOO21_RS01765	COG0754	glutathionylspermidine amidase activity
IOO21_RS01770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
IOO21_RS01775	COG1666	GTP binding
IOO21_RS01790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IOO21_RS01795	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
IOO21_RS01800	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
IOO21_RS01805	COG0284	orotidine-5'-phosphate decarboxylase activity
IOO21_RS01810	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
IOO21_RS01815	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
IOO21_RS01820	COG2877	3-deoxy-8-phosphooctulonate synthase activity
IOO21_RS01830	COG1160	GTP binding
IOO21_RS01835	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
IOO21_RS01845	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
IOO21_RS01860	COG0469	pyruvate kinase activity
IOO21_RS01865	COG0579	oxidoreductase
IOO21_RS01870	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
IOO21_RS01890	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IOO21_RS01925	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
IOO21_RS01945	COG1053	succinate dehydrogenase
IOO21_RS01950	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IOO21_RS02005	COG0488	(ABC) transporter
IOO21_RS02020	COG1739	Uncharacterized protein family UPF0029
IOO21_RS02060	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
IOO21_RS02065	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
IOO21_RS02070	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
IOO21_RS02075	COG1028	Short-chain dehydrogenase reductase Sdr
IOO21_RS02085	COG1053	succinate dehydrogenase
IOO21_RS02090	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
IOO21_RS02095	COG2048	Heterodisulfide reductase, subunit B
IOO21_RS02100	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
IOO21_RS02105	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IOO21_RS02110	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
IOO21_RS02115	COG0825	malonyl-CoA metabolic process
IOO21_RS02120	COG4771	TonB-dependent receptor
IOO21_RS02130	COG0840	transmembrane signaling receptor activity
IOO21_RS02140	COG0227	Belongs to the bacterial ribosomal protein bL28 family
IOO21_RS02145	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
IOO21_RS02155	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
IOO21_RS02175	COG2121	Domain of unknown function (DUF374)
IOO21_RS02180	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IOO21_RS02190	COG0195	Participates in both transcription termination and antitermination
IOO21_RS02200	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IOO21_RS02205	COG0612	Peptidase, M16
IOO21_RS02210	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
IOO21_RS02215	COG2346	COG2346, Truncated hemoglobins
IOO21_RS02225	COG0765	amino acid transport
IOO21_RS02230	COG0765	amino acid transport
IOO21_RS02260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
IOO21_RS02265	COG0267	Belongs to the bacterial ribosomal protein bL33 family
IOO21_RS02280	COG0250	Participates in transcription elongation, termination and antitermination
IOO21_RS02285	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
IOO21_RS02290	COG0081	regulation of translation
IOO21_RS02295	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
IOO21_RS02300	COG0222	ribosome binding
IOO21_RS02305	COG0085	RNA polymerase activity
IOO21_RS02310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
IOO21_RS02315	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
IOO21_RS02320	COG0049	tRNA binding
IOO21_RS02325	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
IOO21_RS02355	COG0134	indole-3-glycerol-phosphate synthase activity
IOO21_RS02365	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
IOO21_RS02390	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
IOO21_RS02395	COG0673	inositol 2-dehydrogenase activity
IOO21_RS02405	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
IOO21_RS02410	COG0424	maF-like protein
IOO21_RS02420	COG0542	response to heat
IOO21_RS02425	COG1937	Protein conserved in bacteria
IOO21_RS02430	COG0793	Belongs to the peptidase S41A family
IOO21_RS02435	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
IOO21_RS02440	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IOO21_RS02445	COG0047	phosphoribosylformylglycinamidine synthase activity
IOO21_RS02455	COG0204	Acyl-transferase
IOO21_RS02460	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
IOO21_RS02465	COG0326	Molecular chaperone. Has ATPase activity
IOO21_RS02470	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
IOO21_RS02490	COG1677	Flagellar hook-basal body complex protein FliE
IOO21_RS02495	COG1558	bacterial-type flagellum-dependent cell motility
IOO21_RS02500	COG1815	bacterial-type flagellum-dependent cell motility
IOO21_RS02520	COG0039	L-malate dehydrogenase activity
IOO21_RS02525	COG0045	succinate-CoA ligase (ADP-forming) activity
IOO21_RS02530	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
IOO21_RS02540	COG0674	pyruvate-flavodoxin oxidoreductase activity
IOO21_RS02540	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
IOO21_RS02545	COG1013	pyruvate-flavodoxin oxidoreductase activity
IOO21_RS02565	COG0142	geranyltranstransferase activity
IOO21_RS02570	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
IOO21_RS02575	COG0442	prolyl-tRNA aminoacylation
IOO21_RS02585	COG0181	hydroxymethylbilane synthase activity
IOO21_RS02590	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
IOO21_RS02600	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
IOO21_RS02620	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
IOO21_RS02650	COG1289	transmembrane transporter activity
IOO21_RS02655	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
IOO21_RS02660	COG0492	ferredoxin-NADP+ reductase activity
IOO21_RS02675	COG0305	Participates in initiation and elongation during chromosome replication
IOO21_RS02740	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IOO21_RS02740	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IOO21_RS02745	COG1610	YqeY-like protein
IOO21_RS02750	COG0028	Belongs to the TPP enzyme family
IOO21_RS02755	COG0440	acetolactate synthase activity
IOO21_RS02765	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
IOO21_RS02770	COG0805	protein transport
IOO21_RS02780	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IOO21_RS02785	COG0494	nUDIX hydrolase
IOO21_RS02790	COG0527	aspartate kinase activity
IOO21_RS02805	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
IOO21_RS02810	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
IOO21_RS02825	COG0196	riboflavin kinase activity
IOO21_RS02830	COG2890	protein-(glutamine-N5) methyltransferase activity
IOO21_RS02845	COG2860	membrane
IOO21_RS02855	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
IOO21_RS02860	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IOO21_RS02865	COG0191	fructose-bisphosphate aldolase activity
IOO21_RS02885	COG0733	neurotransmitter:sodium symporter activity
IOO21_RS02890	COG2258	MOSC domain
IOO21_RS02905	COG1473	amidohydrolase
IOO21_RS02910	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
IOO21_RS02915	COG0577	efflux transmembrane transporter activity
IOO21_RS02915	COG1136	(ABC) transporter
IOO21_RS02920	COG1538	Outer membrane efflux protein
IOO21_RS02935	COG1696	Membrane protein involved in D-alanine export
IOO21_RS02940	COG1528	Iron-storage protein
IOO21_RS02945	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
IOO21_RS02950	COG0573	inorganic phosphate transmembrane transporter activity
IOO21_RS02955	COG0581	inorganic phosphate transmembrane transporter activity
IOO21_RS02975	COG0534	Mate efflux family protein
IOO21_RS02990	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
IOO21_RS03000	COG0298	carbon dioxide binding
IOO21_RS03005	COG0409	Hydrogenase expression formation protein
IOO21_RS03010	COG0309	Hydrogenase expression formation protein (HypE)
IOO21_RS03015	COG0375	protein maturation
IOO21_RS03030	COG0557	exoribonuclease II activity
IOO21_RS03035	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
IOO21_RS03045	COG0758	DNA mediated transformation
IOO21_RS03050	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
IOO21_RS03060	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IOO21_RS03065	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
IOO21_RS03070	COG0563	adenylate kinase activity
IOO21_RS03075	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
IOO21_RS03080	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
IOO21_RS03085	COG0497	DNA recombination
IOO21_RS03095	COG0084	hydrolase, TatD family'
IOO21_RS03100	COG1388	LysM domain
IOO21_RS03100	COG0791	NLP P60 protein
IOO21_RS03105	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
IOO21_RS03165	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
IOO21_RS03170	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
IOO21_RS03175	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
IOO21_RS03180	COG0359	binds to the 23S rRNA
IOO21_RS03185	COG0137	argininosuccinate synthase activity
IOO21_RS03190	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
IOO21_RS03195	COG0802	atpase or kinase
IOO21_RS03200	COG1137	ATPase activity
IOO21_RS03205	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
IOO21_RS03210	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
IOO21_RS03220	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
IOO21_RS03225	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
IOO21_RS03230	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
IOO21_RS03235	COG2205	protein histidine kinase activity
IOO21_RS03240	COG0556	nucleotide-excision repair
IOO21_RS03260	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
IOO21_RS03270	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
IOO21_RS03280	COG0280	phosphate acetyltransferase
IOO21_RS03305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
IOO21_RS03310	COG0849	cell division
IOO21_RS03315	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
IOO21_RS03320	COG4786	Flagellar basal body rod
IOO21_RS03325	COG4786	Flagellar basal body rod
IOO21_RS03330	COG0174	glutamine synthetase
IOO21_RS03340	COG0826	peptidase U32
IOO21_RS03345	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
IOO21_RS03355	COG0752	glycyl-tRNA synthetase alpha subunit
IOO21_RS03360	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
IOO21_RS03370	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IOO21_RS03370	COG1519	Transferase
IOO21_RS03375	COG0564	pseudouridine synthase activity
IOO21_RS03380	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
IOO21_RS03385	COG0228	four-way junction DNA binding
IOO21_RS03390	COG1837	Belongs to the UPF0109 family
IOO21_RS03395	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
IOO21_RS03400	COG0336	Belongs to the RNA methyltransferase TrmD family
IOO21_RS03405	COG0335	large ribosomal subunit rRNA binding
IOO21_RS03415	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
IOO21_RS03420	COG1393	Belongs to the ArsC family
IOO21_RS03430	COG0587	DNA-directed DNA polymerase activity
IOO21_RS03435	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
IOO21_RS03450	COG2890	protein-(glutamine-N5) methyltransferase activity
IOO21_RS03455	COG0501	Belongs to the peptidase M48B family
IOO21_RS03465	COG0521	Mo-molybdopterin cofactor biosynthetic process
IOO21_RS03490	COG1178	ABC-type Fe3 transport system permease component
IOO21_RS03500	COG3842	ATPase activity
IOO21_RS03575	COG1420	regulation of RNA biosynthetic process
IOO21_RS03625	COG0436	Aminotransferase
IOO21_RS03630	COG1045	serine acetyltransferase
IOO21_RS03635	COG1166	arginine decarboxylase activity
IOO21_RS03640	COG0124	histidyl-tRNA synthetase
IOO21_RS03645	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
IOO21_RS03650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
IOO21_RS03655	COG0163	prenyltransferase activity
IOO21_RS03665	COG1464	Belongs to the NlpA lipoprotein family
IOO21_RS03670	COG1464	Belongs to the NlpA lipoprotein family
IOO21_RS03675	COG1464	Belongs to the NlpA lipoprotein family
IOO21_RS03680	COG2011	ABC-type metal ion transport system permease component
IOO21_RS03685	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IOO21_RS03700	COG0210	DNA helicase
IOO21_RS03710	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
IOO21_RS03715	COG0243	molybdopterin cofactor binding
IOO21_RS03720	COG0437	4 iron, 4 sulfur cluster binding
IOO21_RS03725	COG0348	domain, Protein
IOO21_RS03730	COG3043	anaerobic respiration
IOO21_RS03765	COG0788	formyltetrahydrofolate deformylase activity
IOO21_RS03770	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
IOO21_RS03780	COG0642	Histidine kinase
IOO21_RS03790	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
IOO21_RS03805	COG1181	Belongs to the D-alanine--D-alanine ligase family
IOO21_RS03810	COG0632	four-way junction helicase activity
IOO21_RS03820	COG0728	peptidoglycan biosynthetic process
IOO21_RS03825	COG0215	cysteine-tRNA ligase activity
IOO21_RS03830	COG1132	(ABC) transporter
IOO21_RS03835	COG0167	dihydroorotate dehydrogenase activity
IOO21_RS03840	COG0612	Peptidase, M16
IOO21_RS03845	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
IOO21_RS03850	COG1028	Short-chain dehydrogenase reductase Sdr
IOO21_RS03865	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
IOO21_RS03870	COG1663	tetraacyldisaccharide 4'-kinase activity
IOO21_RS03875	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
IOO21_RS03880	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
IOO21_RS03895	COG1338	Plays a role in the flagellum-specific transport system
IOO21_RS03900	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
IOO21_RS03930	COG0101	tRNA pseudouridine synthase activity
IOO21_RS03935	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
IOO21_RS03950	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
IOO21_RS03955	COG1757	Na H antiporter
IOO21_RS03960	COG4221	oxidoreductase activity
IOO21_RS03970	COG1049	propionate catabolic process, 2-methylcitrate cycle
IOO21_RS03975	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
IOO21_RS03985	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOO21_RS03985	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOO21_RS03995	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
IOO21_RS04020	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IOO21_RS04025	COG1408	metallophosphoesterase
IOO21_RS04030	COG0688	phosphatidylethanolamine metabolic process
IOO21_RS04060	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
IOO21_RS04070	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
IOO21_RS04075	COG0681	Belongs to the peptidase S26 family
IOO21_RS04080	COG0303	'Molybdopterin
IOO21_RS04085	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
IOO21_RS04100	COG0512	Glutamine amidotransferase of anthranilate synthase
IOO21_RS04100	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
IOO21_RS04105	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
IOO21_RS04110	COG0582	viral genome integration into host DNA
IOO21_RS04115	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
IOO21_RS04120	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
IOO21_RS04155	COG2404	hydrolase activity, acting on ester bonds
IOO21_RS04160	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
IOO21_RS04165	COG1959	2 iron, 2 sulfur cluster binding
IOO21_RS04170	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
IOO21_RS04175	COG1674	ftsk spoiiie
IOO21_RS04175	COG1196	nuclear chromosome segregation
IOO21_RS04180	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
IOO21_RS04195	COG0488	(ABC) transporter
IOO21_RS04200	COG5002	protein histidine kinase activity
IOO21_RS04205	COG0745	RESPONSE REGULATOR receiver
IOO21_RS04210	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
IOO21_RS04220	COG0539	negative regulation of cytoplasmic translation
IOO21_RS04220	COG1185	polyribonucleotide nucleotidyltransferase activity
IOO21_RS04225	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
IOO21_RS04230	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
IOO21_RS04235	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
IOO21_RS04235	COG0072	phenylalanine-tRNA ligase activity
IOO21_RS04240	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
IOO21_RS04245	COG0537	adenosine 5'-monophosphoramidase activity
IOO21_RS04260	COG0765	amino acid transport
IOO21_RS04270	COG1115	amino acid carrier protein
IOO21_RS04275	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
IOO21_RS04280	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
IOO21_RS04305	COG1999	signal sequence binding
IOO21_RS04310	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
IOO21_RS04315	COG0776	regulation of translation
IOO21_RS04335	COG1966	Carbon starvation protein
IOO21_RS04340	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
IOO21_RS04345	COG0765	amino acid transport
IOO21_RS04350	COG0765	amino acid transport
IOO21_RS04355	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOO21_RS04360	COG1126	abc transporter atp-binding protein
IOO21_RS04365	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
IOO21_RS04370	COG2201	protein-glutamate methylesterase activity
IOO21_RS04385	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
IOO21_RS04395	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
IOO21_RS04400	COG0012	GTP binding
IOO21_RS04405	COG0165	Argininosuccinate lyase
IOO21_RS04410	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
IOO21_RS04415	COG0511	ligase activity, forming carbon-carbon bonds
IOO21_RS04415	COG5016	pyruvate
IOO21_RS04420	COG0733	neurotransmitter:sodium symporter activity
IOO21_RS04425	COG0733	neurotransmitter:sodium symporter activity
IOO21_RS04520	COG0765	amino acid transport
IOO21_RS04535	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
IOO21_RS04545	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
IOO21_RS04560	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
IOO21_RS04575	COG0840	transmembrane signaling receptor activity
IOO21_RS04580	COG0138	bifunctional purine biosynthesis protein purh
IOO21_RS04585	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
IOO21_RS04590	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
IOO21_RS04595	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
IOO21_RS04605	COG0706	membrane insertase activity
IOO21_RS04610	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
IOO21_RS04615	COG0594	ribonuclease P activity
IOO21_RS04620	COG0230	Belongs to the bacterial ribosomal protein bL34 family
IOO21_RS04640	COG0824	Thioesterase
IOO21_RS04670	COG0500	methyltransferase
IOO21_RS04690	COG2195	Cleaves the N-terminal amino acid of tripeptides
IOO21_RS04695	COG0477	Major facilitator Superfamily
IOO21_RS04700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
IOO21_RS04715	COG1473	amidohydrolase
IOO21_RS04720	COG2807	transmembrane transport
IOO21_RS04740	COG2181	nitrate reductase activity
IOO21_RS04740	COG0247	lactate metabolic process
IOO21_RS04745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
IOO21_RS04755	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
IOO21_RS04760	COG0113	porphobilinogen synthase activity
IOO21_RS04765	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
IOO21_RS04770	COG0357	Ribosomal RNA small subunit methyltransferase G
IOO21_RS04780	COG2855	membrane
IOO21_RS04785	COG0583	DNA-binding transcription factor activity
IOO21_RS04790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
IOO21_RS04810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IOO21_RS04815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IOO21_RS04825	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
IOO21_RS04835	COG0343	queuine tRNA-ribosyltransferase activity
IOO21_RS04855	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
IOO21_RS04855	COG1333	cytochrome c biogenesis protein
IOO21_RS04880	COG0683	leucine binding
IOO21_RS04905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
IOO21_RS04910	COG2204	response regulator
IOO21_RS04925	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
IOO21_RS04940	COG0481	GTPase activity
IOO21_RS04965	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
IOO21_RS04975	COG0439	Biotin carboxylase
IOO21_RS04980	COG0772	Belongs to the SEDS family
IOO21_RS04985	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
IOO21_RS05005	COG0352	thiamine-phosphate diphosphorylase activity
IOO21_RS05010	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IOO21_RS05015	COG2022	thiamine diphosphate biosynthetic process
IOO21_RS05030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
IOO21_RS05045	COG1193	negative regulation of DNA recombination
IOO21_RS05055	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
IOO21_RS05075	COG0516	GMP reductase activity
IOO21_RS05075	COG0517	IMP dehydrogenase activity
IOO21_RS05080	COG0154	amidase activity
IOO21_RS05090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
IOO21_RS05095	COG1058	Belongs to the CinA family
IOO21_RS05095	COG1546	Belongs to the CinA family
IOO21_RS05100	COG0456	acetyltransferase
IOO21_RS05105	COG0778	Nitroreductase
IOO21_RS05110	COG0778	Nitroreductase
IOO21_RS05120	COG0750	zinc metalloprotease
IOO21_RS05125	COG2990	Protein conserved in bacteria
IOO21_RS05130	COG0360	Binds together with S18 to 16S ribosomal RNA
IOO21_RS05135	COG0629	single-stranded DNA binding
IOO21_RS05140	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
IOO21_RS05145	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
IOO21_RS05155	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
IOO21_RS05160	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
IOO21_RS05185	COG0352	thiamine-phosphate diphosphorylase activity
IOO21_RS05205	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
IOO21_RS05215	COG0739	heme binding
IOO21_RS05220	COG0285	dihydrofolate synthase activity
IOO21_RS05235	COG0495	leucyl-tRNA aminoacylation
IOO21_RS05240	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IOO21_RS05245	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
IOO21_RS05250	COG1862	Preprotein translocase
IOO21_RS05255	COG0815	Transfers the fatty acyl group on membrane lipoproteins
IOO21_RS05260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
IOO21_RS05265	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
IOO21_RS05270	COG0540	Belongs to the ATCase OTCase family
IOO21_RS05285	COG0210	DNA helicase
IOO21_RS05305	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
IOO21_RS05320	COG0542	response to heat
IOO21_RS05325	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
IOO21_RS05335	COG2095	MarC family integral membrane protein
IOO21_RS05340	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
IOO21_RS05345	COG2833	Protein of unknown function (DUF455)
IOO21_RS05350	COG1183	phosphatidylcholine synthase activity
IOO21_RS05360	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
IOO21_RS05365	COG2264	protein methyltransferase activity
IOO21_RS05370	COG0745	RESPONSE REGULATOR receiver
IOO21_RS05380	COG1086	Polysaccharide biosynthesis protein
IOO21_RS05385	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IOO21_RS05390	COG0110	maltose O-acetyltransferase activity
IOO21_RS05395	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
IOO21_RS05400	COG0438	transferase activity, transferring glycosyl groups
IOO21_RS05410	COG0438	transferase activity, transferring glycosyl groups
IOO21_RS05415	COG1215	transferase activity, transferring glycosyl groups
IOO21_RS05420	COG0438	transferase activity, transferring glycosyl groups
IOO21_RS05425	COG1132	(ABC) transporter
IOO21_RS05430	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
IOO21_RS05440	COG0859	PFAM glycosyl transferase family 9
IOO21_RS05445	COG1560	Kdo2-lipid A biosynthetic process
IOO21_RS05450	COG0463	Glycosyl transferase, family 2
IOO21_RS05470	COG1442	glycosyl transferase family 8
IOO21_RS05470	COG1216	Glycosyl transferase, family 2
IOO21_RS05480	COG2089	acid synthase
IOO21_RS05505	COG1216	Glycosyl transferase, family 2
IOO21_RS05525	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
IOO21_RS05525	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
IOO21_RS05535	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IOO21_RS05550	COG2217	Heavy metal translocating P-type atpase
IOO21_RS05555	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
IOO21_RS05560	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
IOO21_RS05570	COG2217	Heavy metal translocating P-type atpase
IOO21_RS05590	COG3610	response to peptide
IOO21_RS05600	COG0039	L-malate dehydrogenase activity
IOO21_RS05605	COG0586	Pfam SNARE associated Golgi protein
IOO21_RS05620	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
IOO21_RS05625	COG0217	transcriptional regulatory protein
IOO21_RS05640	COG0018	arginyl-trna synthetase
IOO21_RS05645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
IOO21_RS05650	COG0194	GDP metabolic process
IOO21_RS05660	COG1684	flagellar biosynthetic protein fliR
IOO21_RS05670	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
IOO21_RS05675	COG0052	Belongs to the universal ribosomal protein uS2 family
IOO21_RS05680	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
IOO21_RS05690	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
IOO21_RS05695	COG0723	plastoquinol--plastocyanin reductase activity
IOO21_RS05700	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
IOO21_RS05705	COG0445	tRNA wobble uridine modification
IOO21_RS05725	COG1301	dicarboxylic acid transport
IOO21_RS05740	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
IOO21_RS05745	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
IOO21_RS05750	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
IOO21_RS05755	COG1854	S-ribosylhomocysteine lyase activity
IOO21_RS05770	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
IOO21_RS05775	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
IOO21_RS05785	COG0356	it plays a direct role in the translocation of protons across the membrane
IOO21_RS05790	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
IOO21_RS05795	COG0552	protein localization to endoplasmic reticulum
IOO21_RS05810	COG1418	mRNA catabolic process
IOO21_RS05825	COG1295	ribonuclease BN
IOO21_RS05830	COG0277	FAD linked oxidase domain protein
IOO21_RS05840	COG0739	heme binding
IOO21_RS05850	COG1496	oxidoreductase activity
IOO21_RS05865	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
IOO21_RS05870	COG0459	protein refolding
IOO21_RS05875	COG0642	Histidine kinase
IOO21_RS05880	COG0745	RESPONSE REGULATOR receiver
IOO21_RS05900	COG0642	Histidine kinase
IOO21_RS05905	COG0745	RESPONSE REGULATOR receiver
IOO21_RS05910	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
IOO21_RS05915	COG0484	heat shock protein binding
IOO21_RS05920	COG0789	Transcriptional regulator
IOO21_RS05925	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
IOO21_RS05925	COG0475	glutathione-regulated potassium exporter activity
IOO21_RS05940	COG0751	glycine-tRNA ligase activity
IOO21_RS05945	COG0739	heme binding
IOO21_RS05955	COG0248	Ppx GppA phosphatase
IOO21_RS05960	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
IOO21_RS05965	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
IOO21_RS05975	COG2814	Major facilitator Superfamily
IOO21_RS05985	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
IOO21_RS05990	COG0731	radical SAM domain protein
IOO21_RS06000	COG0322	excinuclease ABC activity
IOO21_RS06010	COG0519	Catalyzes the synthesis of GMP from XMP
IOO21_RS06010	COG0518	GMP synthase (glutamine-hydrolyzing) activity
IOO21_RS06035	COG1185	polyribonucleotide nucleotidyltransferase activity
IOO21_RS06045	COG1942	4-Oxalocrotonate Tautomerase
IOO21_RS06060	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
IOO21_RS06065	COG4773	Receptor
IOO21_RS06070	COG0484	heat shock protein binding
IOO21_RS06075	COG0745	RESPONSE REGULATOR receiver
IOO21_RS06080	COG0642	Histidine kinase
IOO21_RS06085	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
IOO21_RS06090	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
IOO21_RS06095	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
IOO21_RS06100	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
IOO21_RS06105	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
IOO21_RS06110	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
IOO21_RS06110	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
IOO21_RS06125	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
IOO21_RS06130	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
IOO21_RS06135	COG1758	RNA polymerase activity
IOO21_RS06140	COG0528	UMP kinase activity
IOO21_RS06155	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
IOO21_RS06160	COG0220	tRNA (guanine-N7-)-methyltransferase activity
IOO21_RS06170	COG0564	pseudouridine synthase activity
IOO21_RS06175	COG0772	Belongs to the SEDS family
IOO21_RS06190	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
IOO21_RS06195	COG0569	domain protein
IOO21_RS06200	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IOO21_RS06205	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
IOO21_RS06210	COG0281	malic enzyme
IOO21_RS06210	COG0280	phosphate acetyltransferase
IOO21_RS06215	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
IOO21_RS06225	COG0439	Biotin carboxylase
IOO21_RS06230	COG0511	ligase activity, forming carbon-carbon bonds
IOO21_RS06240	COG1086	Polysaccharide biosynthesis protein
IOO21_RS06245	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
IOO21_RS06265	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
IOO21_RS06280	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
IOO21_RS06325	COG1083	cytidylyl-transferase
IOO21_RS06330	COG3980	spore coat polysaccharide biosynthesis protein
IOO21_RS06335	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
IOO21_RS06340	COG0107	imidazoleglycerol-phosphate synthase activity
IOO21_RS06345	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
IOO21_RS06355	COG2089	acid synthase
IOO21_RS06395	COG2165	general secretion pathway protein
IOO21_RS06400	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
IOO21_RS06410	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
IOO21_RS06415	COG0575	Belongs to the CDS family
IOO21_RS06425	COG1293	RNA-binding protein homologous to eukaryotic snRNP
IOO21_RS06430	COG0746	molybdenum cofactor guanylyltransferase activity
IOO21_RS06435	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
IOO21_RS06440	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOO21_RS06445	COG4605	iron ion homeostasis
IOO21_RS06450	COG4604	ABC transporter, ATP-binding protein
IOO21_RS06455	COG4607	ABC-type enterochelin transport system periplasmic component
IOO21_RS06480	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
IOO21_RS06485	COG3005	denitrification pathway
IOO21_RS06490	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
IOO21_RS06505	COG2255	four-way junction helicase activity
IOO21_RS06510	COG0628	permease
IOO21_RS06515	COG0114	fumarate hydratase activity
IOO21_RS06525	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
IOO21_RS06535	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
IOO21_RS06545	COG2252	PERMEase
IOO21_RS06555	COG2853	Lipoprotein
IOO21_RS06570	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
IOO21_RS06575	COG2814	Major facilitator Superfamily
IOO21_RS06585	COG1921	L-seryl-tRNASec selenium transferase activity
IOO21_RS06590	COG3276	selenocysteine insertion sequence binding
IOO21_RS06605	COG0716	FMN binding
IOO21_RS06620	COG0753	catalase activity
IOO21_RS06630	COG2964	Protein conserved in bacteria
IOO21_RS06635	COG0251	oxidation-reduction process
IOO21_RS06640	COG3069	C4-dicarboxylate transmembrane transporter activity
IOO21_RS06660	COG1918	ferrous iron import across plasma membrane
IOO21_RS06670	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
IOO21_RS06675	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
IOO21_RS06685	COG0126	phosphoglycerate kinase activity
IOO21_RS06690	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
IOO21_RS06695	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
IOO21_RS06715	COG1580	Controls the rotational direction of flagella during chemotaxis
IOO21_RS06720	COG0736	holo-[acyl-carrier-protein] synthase activity
IOO21_RS06730	COG2124	cytochrome p450
IOO21_RS06750	COG0529	Catalyzes the synthesis of activated sulfate
IOO21_RS06755	COG1213	nucleotidyl transferase
IOO21_RS06760	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
IOO21_RS06765	COG3848	Pyruvate phosphate dikinase
IOO21_RS06765	COG0574	Belongs to the PEP-utilizing enzyme family
IOO21_RS06770	COG2226	methyltransferase
IOO21_RS06790	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
IOO21_RS06810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
IOO21_RS06830	COG1216	Glycosyl transferase, family 2
IOO21_RS06830	COG1442	glycosyl transferase family 8
IOO21_RS06855	COG3562	capsule polysaccharide
IOO21_RS06860	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
IOO21_RS06860	COG0517	IMP dehydrogenase activity
IOO21_RS06905	COG0037	tRNA processing
IOO21_RS06910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
IOO21_RS06915	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
IOO21_RS06925	COG0585	pseudouridine synthase activity
IOO21_RS06930	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
IOO21_RS06950	COG1706	bacterial-type flagellum-dependent cell motility
IOO21_RS06955	COG3951	Flagellar rod assembly protein muramidase FlgJ
IOO21_RS06980	COG0730	response to heat
IOO21_RS06985	COG1459	type II secretion system
IOO21_RS06990	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
IOO21_RS07020	COG0546	phosphoglycolate phosphatase activity
IOO21_RS07030	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
IOO21_RS07035	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
IOO21_RS07040	COG0210	DNA helicase
IOO21_RS07045	COG2887	Belongs to the helicase family. UvrD subfamily
IOO21_RS07090	COG0745	RESPONSE REGULATOR receiver
IOO21_RS07105	COG0505	Belongs to the CarA family
IOO21_RS07125	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
IOO21_RS07140	COG0425	Belongs to the sulfur carrier protein TusA family
IOO21_RS07145	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
IOO21_RS07175	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
IOO21_RS07185	COG0437	4 iron, 4 sulfur cluster binding
IOO21_RS07220	COG0314	molybdopterin synthase activity
IOO21_RS07225	COG0303	'Molybdopterin
IOO21_RS07240	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
IOO21_RS07245	COG0237	dephospho-CoA kinase activity
IOO21_RS07250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
IOO21_RS07255	COG2992	FlgJ-related protein
IOO21_RS07265	COG0783	Belongs to the Dps family
IOO21_RS07270	COG0166	Belongs to the GPI family
IOO21_RS07285	COG3839	Belongs to the ABC transporter superfamily
IOO21_RS07290	COG4662	Binding-protein-dependent transport system inner membrane component
IOO21_RS07295	COG2998	abc-type tungstate transport system, permease component
IOO21_RS07300	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
IOO21_RS07305	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
IOO21_RS07310	COG1984	allophanate hydrolase subunit 2
IOO21_RS07320	COG2249	NAD(P)H dehydrogenase (quinone) activity
IOO21_RS07325	COG1733	regulation of RNA biosynthetic process
IOO21_RS07335	COG1064	alcohol dehydrogenase
IOO21_RS07380	COG2814	Major facilitator Superfamily
IOO21_RS07415	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOO21_RS07420	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
IOO21_RS07430	COG0839	Belongs to the complex I subunit 6 family
IOO21_RS07435	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOO21_RS07440	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
IOO21_RS07465	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOO21_RS07470	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOO21_RS07475	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
IOO21_RS07480	COG4608	Belongs to the ABC transporter superfamily
IOO21_RS07490	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
IOO21_RS07495	COG0601	transmembrane transport
IOO21_RS07505	COG0243	molybdopterin cofactor binding
IOO21_RS07510	COG0437	4 iron, 4 sulfur cluster binding
IOO21_RS07535	COG4615	Cyclic peptide transporter
IOO21_RS07545	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
IOO21_RS07550	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
IOO21_RS07555	COG0257	Belongs to the bacterial ribosomal protein bL36 family
IOO21_RS07560	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
IOO21_RS07565	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
IOO21_RS07570	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
IOO21_RS07575	COG0202	RNA polymerase activity
IOO21_RS07580	COG0203	ribosomal protein L17
IOO21_RS07585	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
IOO21_RS07595	COG0131	Imidazoleglycerol-phosphate dehydratase
IOO21_RS07595	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
IOO21_RS07605	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
IOO21_RS07620	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
IOO21_RS07620	COG0140	phosphoribosyl-ATP diphosphatase activity
IOO21_RS07625	COG2171	N-acyltransferase activity
IOO21_RS07630	COG0489	protein tyrosine kinase activity
IOO21_RS07635	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
IOO21_RS07635	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
IOO21_RS07640	COG0745	RESPONSE REGULATOR receiver
IOO21_RS07645	COG2046	Belongs to the sulfate adenylyltransferase family
IOO21_RS07650	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
IOO21_RS07655	COG0268	Binds directly to 16S ribosomal RNA
IOO21_RS07660	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
IOO21_RS07665	COG0748	coenzyme F420 binding
IOO21_RS07675	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
IOO21_RS07680	COG1120	ATPase activity
IOO21_RS07685	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
IOO21_RS07695	COG0477	Major facilitator Superfamily
IOO21_RS07700	COG1194	a g-specific adenine glycosylase
IOO21_RS07730	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IOO21_RS07730	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
IOO21_RS07740	COG1760	l-serine dehydratase
IOO21_RS07745	COG0814	amino acid
IOO21_RS07760	COG0811	peptide transport
IOO21_RS07765	COG0848	biopolymer transport protein
IOO21_RS07790	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
IOO21_RS07800	COG0328	RNA-DNA hybrid ribonuclease activity
IOO21_RS07810	COG0358	DNA primase activity
IOO21_RS07825	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
IOO21_RS07830	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
IOO21_RS07845	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
IOO21_RS07850	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
IOO21_RS07855	COG1127	ABC transporter
IOO21_RS07865	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
IOO21_RS07865	COG3218	ABC-type transport auxiliary lipoprotein component
IOO21_RS07875	COG0024	Methionine aminopeptidase
IOO21_RS07880	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
IOO21_RS07885	COG0791	NLP P60 protein
IOO21_RS07890	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IOO21_RS07895	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
IOO21_RS07910	COG0672	)-iron permease
IOO21_RS07935	COG1136	(ABC) transporter
IOO21_RS07985	COG1793	dna ligase
IOO21_RS08000	COG0148	phosphopyruvate hydratase activity
IOO21_RS08005	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
IOO21_RS08010	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
IOO21_RS08015	COG1987	bacterial-type flagellum assembly
IOO21_RS08030	COG1218	3'(2'),5'-bisphosphate nucleotidase
IOO21_RS08035	COG0372	Belongs to the citrate synthase family
IOO21_RS08045	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
IOO21_RS08050	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
IOO21_RS08060	COG2936	dipeptidyl-peptidase activity
IOO21_RS08075	COG0201	protein transport
IOO21_RS08080	COG0200	Binds to the 23S rRNA
IOO21_RS08085	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
IOO21_RS08090	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
IOO21_RS08095	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
IOO21_RS08100	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
IOO21_RS08105	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
IOO21_RS08110	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
IOO21_RS08115	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
IOO21_RS08120	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
IOO21_RS08125	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
IOO21_RS08130	COG0255	Belongs to the universal ribosomal protein uL29 family
IOO21_RS08135	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
IOO21_RS08140	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
IOO21_RS08145	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
IOO21_RS08150	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
IOO21_RS08155	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
IOO21_RS08160	COG0089	rRNA binding
IOO21_RS08165	COG0088	Forms part of the polypeptide exit tunnel
IOO21_RS08170	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
IOO21_RS08175	COG0051	transcription antitermination factor activity, RNA binding
IOO21_RS08180	COG1187	pseudouridine synthase activity
IOO21_RS08185	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
IOO21_RS08200	COG0820	rRNA (adenine-C2-)-methyltransferase activity
IOO21_RS08240	COG0066	3-isopropylmalate dehydratase activity
IOO21_RS08245	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
IOO21_RS08250	COG0473	3-isopropylmalate dehydrogenase activity
IOO21_RS08255	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
IOO21_RS08270	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
IOO21_RS08280	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
IOO21_RS08290	COG1749	Flagellar hook protein flgE