locus-tag	class	description
N565_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
N565_RS00010	COG0592	DNA-directed DNA polymerase activity
N565_RS00015	COG0187	DNA topoisomerase II activity
N565_RS00030	COG2056	Na+-H+ antiporter family
N565_RS00035	COG0069	glutamate synthase activity
N565_RS00035	COG0067	glutamate synthase
N565_RS00035	COG0070	glutamate synthase
N565_RS00045	COG0493	'glutamate synthase
N565_RS00050	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
N565_RS00060	COG1592	Rubrerythrin
N565_RS00065	COG0129	dihydroxy-acid dehydratase activity
N565_RS00070	COG3477	response to acidic pH
N565_RS00080	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
N565_RS00100	COG1858	cytochrome C peroxidase
N565_RS00105	COG0179	Fumarylacetoacetate (FAA) hydrolase
N565_RS00110	COG0564	pseudouridine synthase activity
N565_RS00115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
N565_RS00120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N565_RS00125	COG1823	symporter activity
N565_RS00135	COG0504	CTP synthase activity
N565_RS00145	COG0252	asparaginase activity
N565_RS00180	COG2890	protein-(glutamine-N5) methyltransferase activity
N565_RS00195	COG2814	Major facilitator Superfamily
N565_RS00215	COG1217	gtp-binding protein TYPA
N565_RS00230	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
N565_RS00255	COG0471	metal ion transport
N565_RS00270	COG0471	metal ion transport
N565_RS00305	COG1776	CheC inhibitor of MCP methylation
N565_RS00305	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N565_RS00310	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N565_RS00315	COG1191	sigma factor activity
N565_RS00325	COG0455	bacterial-type flagellum organization
N565_RS00330	COG1419	protein localization to endoplasmic reticulum
N565_RS00335	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
N565_RS00340	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
N565_RS00345	COG0402	S-adenosylhomocysteine deaminase activity
N565_RS00350	COG0616	signal peptide processing
N565_RS00380	COG1139	Iron-sulfur cluster binding protein
N565_RS00385	COG0247	lactate metabolic process
N565_RS00400	COG3021	interspecies interaction between organisms
N565_RS00415	COG1271	oxidase subunit
N565_RS00420	COG1294	oxidase, subunit
N565_RS00430	COG1794	racemase activity, acting on amino acids and derivatives
N565_RS00435	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
N565_RS00440	COG1027	Aspartate ammonia-lyase
N565_RS00445	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
N565_RS00475	COG0261	This protein binds to 23S rRNA in the presence of protein L20
N565_RS00480	COG0211	Belongs to the bacterial ribosomal protein bL27 family
N565_RS00485	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
N565_RS00495	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
N565_RS00500	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
N565_RS00500	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
N565_RS00505	COG1192	Involved in chromosome partitioning
N565_RS00510	COG1475	DNA binding
N565_RS00520	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
N565_RS00525	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N565_RS00535	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
N565_RS00540	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
N565_RS00545	COG0355	proton-transporting ATP synthase activity, rotational mechanism
N565_RS00550	COG0811	peptide transport
N565_RS00555	COG0848	biopolymer transport protein
N565_RS00565	COG0823	Involved in the tonB-independent uptake of proteins
N565_RS00570	COG2885	chlorophyll binding
N565_RS00580	COG1047	Peptidyl-prolyl cis-trans
N565_RS00585	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
N565_RS00590	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
N565_RS00595	COG0037	tRNA processing
N565_RS00620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
N565_RS00630	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
N565_RS00635	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
N565_RS00640	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
N565_RS00650	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
N565_RS00665	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
N565_RS00675	COG0083	homoserine kinase activity
N565_RS00700	COG1401	restriction endodeoxyribonuclease activity
N565_RS00710	COG1108	ABC-type Mn2 Zn2 transport systems permease components
N565_RS00715	COG1121	(ABC) transporter
N565_RS00730	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N565_RS00740	COG0418	dihydroorotase activity
N565_RS00750	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
N565_RS00755	COG2194	sulfuric ester hydrolase activity
N565_RS00760	COG0708	Exodeoxyribonuclease III
N565_RS00770	COG2921	Belongs to the UPF0250 family
N565_RS00775	COG0315	cyclic pyranopterin monophosphate synthase activity
N565_RS00785	COG0477	Major facilitator Superfamily
N565_RS00805	COG3290	protein histidine kinase activity
N565_RS00805	COG0840	transmembrane signaling receptor activity
N565_RS00810	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
N565_RS00815	COG0291	Belongs to the bacterial ribosomal protein bL35 family
N565_RS00840	COG0668	transmembrane transport
N565_RS00845	COG0288	reversible hydration of carbon dioxide
N565_RS00850	COG0670	Belongs to the BI1 family
N565_RS00855	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
N565_RS00860	COG0233	cytoplasmic translational termination
N565_RS00865	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
N565_RS00875	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
N565_RS00885	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
N565_RS00890	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
N565_RS00895	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
N565_RS00900	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
N565_RS00910	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
N565_RS00945	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
N565_RS00950	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
N565_RS00955	COG1968	undecaprenyl-diphosphatase activity
N565_RS00960	COG1297	OPT oligopeptide transporter protein
N565_RS00965	COG2851	Citrate transporter
N565_RS00990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
N565_RS00990	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
N565_RS00995	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
N565_RS01000	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
N565_RS01005	COG1157	protein secretion by the type III secretion system
N565_RS01010	COG0302	gtp cyclohydrolase
N565_RS01015	COG0544	peptidyl-prolyl cis-trans isomerase activity
N565_RS01025	COG0242	peptide deformylase activity
N565_RS01030	COG0606	chelatase, subunit chli
N565_RS01040	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
N565_RS01040	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
N565_RS01045	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
N565_RS01050	COG0861	Integral membrane protein TerC family
N565_RS01055	COG2824	Alkylphosphonate utilization operon protein PhnA
N565_RS01065	COG1253	flavin adenine dinucleotide binding
N565_RS01070	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
N565_RS01080	COG0848	biopolymer transport protein
N565_RS01085	COG0811	peptide transport
N565_RS01090	COG4206	TonB-dependent receptor
N565_RS01090	COG1629	transport
N565_RS01105	COG1840	ABC-type Fe3 transport system, periplasmic component
N565_RS01130	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
N565_RS01145	COG1971	Probably functions as a manganese efflux pump
N565_RS01170	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
N565_RS01175	COG0602	queuosine metabolic process
N565_RS01195	COG1385	rRNA (uridine-N3-)-methyltransferase activity
N565_RS01200	COG0254	rRNA binding
N565_RS01205	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
N565_RS01210	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
N565_RS01225	COG0436	Aminotransferase
N565_RS01230	COG0460	homoserine dehydrogenase
N565_RS01235	COG0792	nuclease activity
N565_RS01240	COG3118	belongs to the thioredoxin family
N565_RS01245	COG0492	ferredoxin-NADP+ reductase activity
N565_RS01260	COG0428	transporter
N565_RS01265	COG0243	molybdopterin cofactor binding
N565_RS01285	COG0330	HflC and HflK could
N565_RS01295	COG1942	4-Oxalocrotonate Tautomerase
N565_RS01300	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
N565_RS01305	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
N565_RS01310	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
N565_RS01315	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N565_RS01320	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
N565_RS01325	COG1077	Cell shape determining protein MreB Mrl
N565_RS01335	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
N565_RS01355	COG0835	chemotaxis
N565_RS01360	COG2198	Histidine kinase
N565_RS01360	COG0643	Histidine kinase
N565_RS01360	COG0784	Response regulator, receiver
N565_RS01365	COG0784	Response regulator, receiver
N565_RS01365	COG0835	chemotaxis
N565_RS01380	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
N565_RS01405	COG0454	-acetyltransferase
N565_RS01735	COG4106	trans-aconitate 2-methyltransferase activity
N565_RS01740	COG2830	Protein of unknown function (DUF452)
N565_RS01750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
N565_RS01755	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
N565_RS01760	COG2076	Multidrug Resistance protein
N565_RS01785	COG0019	diaminopimelate decarboxylase activity
N565_RS01800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N565_RS01810	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N565_RS01820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
N565_RS01835	COG2226	methyltransferase
N565_RS01840	COG1570	exodeoxyribonuclease VII activity
N565_RS01845	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
N565_RS01850	COG0251	oxidation-reduction process
N565_RS01855	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N565_RS01860	COG0416	fatty acid biosynthetic process
N565_RS01865	COG0333	Belongs to the bacterial ribosomal protein bL32 family
N565_RS01875	COG0105	UTP biosynthetic process
N565_RS01885	COG0450	alkyl hydroperoxide reductase
N565_RS01890	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N565_RS01895	COG1360	Flagellar Motor Protein
N565_RS01900	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
N565_RS01910	COG0477	Major facilitator Superfamily
N565_RS01920	COG1238	metal cluster binding
N565_RS01925	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
N565_RS01930	COG0730	response to heat
N565_RS01945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N565_RS01945	COG0512	Glutamine amidotransferase of anthranilate synthase
N565_RS01955	COG0133	tryptophan synthase activity
N565_RS01970	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
N565_RS01970	COG1776	CheC inhibitor of MCP methylation
N565_RS01985	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
N565_RS01990	COG0745	RESPONSE REGULATOR receiver
N565_RS02000	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
N565_RS02015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
N565_RS02020	COG1981	membrane
N565_RS02025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N565_RS02035	COG1538	Outer membrane efflux protein
N565_RS02045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N565_RS02060	COG0828	Belongs to the bacterial ribosomal protein bS21 family
N565_RS02070	COG0754	glutathionylspermidine amidase activity
N565_RS02075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
N565_RS02080	COG1666	GTP binding
N565_RS02095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N565_RS02105	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
N565_RS02115	COG0284	orotidine-5'-phosphate decarboxylase activity
N565_RS02125	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
N565_RS02155	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
N565_RS02170	COG0469	pyruvate kinase activity
N565_RS02175	COG0579	oxidoreductase
N565_RS02180	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
N565_RS02215	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
N565_RS02220	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
N565_RS02235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
N565_RS02255	COG1053	succinate dehydrogenase
N565_RS02260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N565_RS02310	COG2353	YceI-like domain
N565_RS02340	COG0488	(ABC) transporter
N565_RS02355	COG1739	Uncharacterized protein family UPF0029
N565_RS02395	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
N565_RS02400	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
N565_RS02405	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
N565_RS02415	COG1028	Short-chain dehydrogenase reductase Sdr
N565_RS02425	COG1053	succinate dehydrogenase
N565_RS02430	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
N565_RS02435	COG2048	Heterodisulfide reductase, subunit B
N565_RS02440	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
N565_RS02445	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
N565_RS02450	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
N565_RS02455	COG0825	malonyl-CoA metabolic process
N565_RS02480	COG0227	Belongs to the bacterial ribosomal protein bL28 family
N565_RS02485	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
N565_RS02495	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
N565_RS02515	COG2121	Domain of unknown function (DUF374)
N565_RS02520	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N565_RS02530	COG0195	Participates in both transcription termination and antitermination
N565_RS02540	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
N565_RS02545	COG0612	Peptidase, M16
N565_RS02550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
N565_RS02555	COG2346	COG2346, Truncated hemoglobins
N565_RS02570	COG0765	amino acid transport
N565_RS02600	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
N565_RS02605	COG0267	Belongs to the bacterial ribosomal protein bL33 family
N565_RS02620	COG0250	Participates in transcription elongation, termination and antitermination
N565_RS02625	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
N565_RS02630	COG0081	regulation of translation
N565_RS02635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
N565_RS02640	COG0222	ribosome binding
N565_RS02645	COG0085	RNA polymerase activity
N565_RS02650	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
N565_RS02660	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N565_RS02670	COG2721	sulfolactate sulfo-lyase activity
N565_RS02675	COG2271	Major facilitator Superfamily
N565_RS02680	COG1028	Short-chain dehydrogenase reductase Sdr
N565_RS02685	COG0738	Major facilitator superfamily
N565_RS02695	COG3254	rhamnose metabolic process
N565_RS02700	COG1012	belongs to the aldehyde dehydrogenase family
N565_RS02705	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
N565_RS02710	COG0049	tRNA binding
N565_RS02755	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
N565_RS02770	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
N565_RS02775	COG0673	inositol 2-dehydrogenase activity
N565_RS02785	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
N565_RS02790	COG0424	maF-like protein
N565_RS02800	COG0542	response to heat
N565_RS02805	COG1937	Protein conserved in bacteria
N565_RS02810	COG0793	Belongs to the peptidase S41A family
N565_RS02815	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
N565_RS02820	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N565_RS02825	COG0047	phosphoribosylformylglycinamidine synthase activity
N565_RS02835	COG0204	Acyl-transferase
N565_RS02850	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
N565_RS02880	COG1677	Flagellar hook-basal body complex protein FliE
N565_RS02885	COG1558	bacterial-type flagellum-dependent cell motility
N565_RS02890	COG1815	bacterial-type flagellum-dependent cell motility
N565_RS02910	COG0039	L-malate dehydrogenase activity
N565_RS02920	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
N565_RS02930	COG0674	pyruvate-flavodoxin oxidoreductase activity
N565_RS02930	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
N565_RS02935	COG1013	pyruvate-flavodoxin oxidoreductase activity
N565_RS02955	COG0142	geranyltranstransferase activity
N565_RS02960	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
N565_RS02965	COG0442	prolyl-tRNA aminoacylation
N565_RS02975	COG0181	hydroxymethylbilane synthase activity
N565_RS02980	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
N565_RS02990	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
N565_RS03005	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
N565_RS03035	COG1289	transmembrane transporter activity
N565_RS03040	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
N565_RS03045	COG0492	ferredoxin-NADP+ reductase activity
N565_RS03060	COG0305	Participates in initiation and elongation during chromosome replication
N565_RS03075	COG4735	regulation of single-species biofilm formation
N565_RS03120	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N565_RS03120	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N565_RS03125	COG1610	YqeY-like protein
N565_RS03130	COG0028	Belongs to the TPP enzyme family
N565_RS03135	COG0440	acetolactate synthase activity
N565_RS03145	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
N565_RS03150	COG0805	protein transport
N565_RS03160	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N565_RS03165	COG0494	nUDIX hydrolase
N565_RS03170	COG0527	aspartate kinase activity
N565_RS03185	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
N565_RS03190	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
N565_RS03205	COG0196	riboflavin kinase activity
N565_RS03210	COG2890	protein-(glutamine-N5) methyltransferase activity
N565_RS03225	COG2860	membrane
N565_RS03235	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
N565_RS03240	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N565_RS03245	COG0191	fructose-bisphosphate aldolase activity
N565_RS03265	COG0733	neurotransmitter:sodium symporter activity
N565_RS03270	COG2258	MOSC domain
N565_RS03285	COG1473	amidohydrolase
N565_RS03290	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
N565_RS03295	COG1136	(ABC) transporter
N565_RS03295	COG0577	efflux transmembrane transporter activity
N565_RS03300	COG1538	Outer membrane efflux protein
N565_RS03315	COG1696	Membrane protein involved in D-alanine export
N565_RS03320	COG1528	Iron-storage protein
N565_RS03325	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
N565_RS03330	COG0573	inorganic phosphate transmembrane transporter activity
N565_RS03335	COG0581	inorganic phosphate transmembrane transporter activity
N565_RS03350	COG0534	Mate efflux family protein
N565_RS03365	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
N565_RS03375	COG0298	carbon dioxide binding
N565_RS03380	COG0409	Hydrogenase expression formation protein
N565_RS03385	COG0309	Hydrogenase expression formation protein (HypE)
N565_RS03390	COG0375	protein maturation
N565_RS03405	COG0557	exoribonuclease II activity
N565_RS03410	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
N565_RS03420	COG0758	DNA mediated transformation
N565_RS03435	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N565_RS03440	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
N565_RS03445	COG0563	adenylate kinase activity
N565_RS03450	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
N565_RS03455	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
N565_RS03460	COG0497	DNA recombination
N565_RS03470	COG0084	hydrolase, TatD family'
N565_RS03475	COG0791	NLP P60 protein
N565_RS03475	COG1388	LysM domain
N565_RS03480	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
N565_RS03500	COG0218	Necessary for normal cell division and for the maintenance of normal septation
N565_RS03540	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
N565_RS03545	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
N565_RS03560	COG0137	argininosuccinate synthase activity
N565_RS03565	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
N565_RS03570	COG0802	atpase or kinase
N565_RS03575	COG1137	ATPase activity
N565_RS03580	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
N565_RS03585	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
N565_RS03610	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
N565_RS03620	COG2205	protein histidine kinase activity
N565_RS03645	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
N565_RS03655	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
N565_RS03665	COG0280	phosphate acetyltransferase
N565_RS03690	COG0275	rRNA processing
N565_RS03695	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
N565_RS03700	COG0849	cell division
N565_RS03705	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
N565_RS03710	COG4786	Flagellar basal body rod
N565_RS03715	COG4786	Flagellar basal body rod
N565_RS03720	COG0174	glutamine synthetase
N565_RS03730	COG0826	peptidase U32
N565_RS03735	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
N565_RS03745	COG0752	glycyl-tRNA synthetase alpha subunit
N565_RS03750	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
N565_RS03760	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N565_RS03760	COG1519	Transferase
N565_RS03765	COG0564	pseudouridine synthase activity
N565_RS03770	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
N565_RS03775	COG0228	four-way junction DNA binding
N565_RS03780	COG1837	Belongs to the UPF0109 family
N565_RS03785	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
N565_RS03790	COG0336	Belongs to the RNA methyltransferase TrmD family
N565_RS03805	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
N565_RS03810	COG1393	Belongs to the ArsC family
N565_RS03815	COG0587	DNA-directed DNA polymerase activity
N565_RS03820	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
N565_RS03825	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N565_RS03835	COG2890	protein-(glutamine-N5) methyltransferase activity
N565_RS03840	COG0501	Belongs to the peptidase M48B family
N565_RS03850	COG0521	Mo-molybdopterin cofactor biosynthetic process
N565_RS03855	COG0598	Magnesium transport protein CorA
N565_RS03980	COG0675	Transposase, IS605 OrfB family
N565_RS03990	COG4771	TonB-dependent receptor
N565_RS03995	COG1420	regulation of RNA biosynthetic process
N565_RS04000	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
N565_RS04005	COG0443	Heat shock 70 kDa protein
N565_RS04020	COG0436	Aminotransferase
N565_RS04025	COG1045	serine acetyltransferase
N565_RS04030	COG1166	arginine decarboxylase activity
N565_RS04045	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
N565_RS04050	COG0163	prenyltransferase activity
N565_RS04060	COG1464	Belongs to the NlpA lipoprotein family
N565_RS04065	COG1464	Belongs to the NlpA lipoprotein family
N565_RS04070	COG1464	Belongs to the NlpA lipoprotein family
N565_RS04075	COG2011	ABC-type metal ion transport system permease component
N565_RS04080	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N565_RS04095	COG0210	DNA helicase
N565_RS04105	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
N565_RS04115	COG0437	4 iron, 4 sulfur cluster binding
N565_RS04120	COG0348	domain, Protein
N565_RS04125	COG3043	anaerobic respiration
N565_RS04160	COG0788	formyltetrahydrofolate deformylase activity
N565_RS04165	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
N565_RS04175	COG0642	Histidine kinase
N565_RS04200	COG1181	Belongs to the D-alanine--D-alanine ligase family
N565_RS04205	COG0632	four-way junction helicase activity
N565_RS04215	COG0728	peptidoglycan biosynthetic process
N565_RS04220	COG0215	cysteine-tRNA ligase activity
N565_RS04225	COG1132	(ABC) transporter
N565_RS04230	COG0167	dihydroorotate dehydrogenase activity
N565_RS04235	COG0612	Peptidase, M16
N565_RS04240	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
N565_RS04245	COG1028	Short-chain dehydrogenase reductase Sdr
N565_RS04260	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
N565_RS04265	COG1663	tetraacyldisaccharide 4'-kinase activity
N565_RS04270	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
N565_RS04275	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
N565_RS04290	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N565_RS04305	COG1338	Plays a role in the flagellum-specific transport system
N565_RS04310	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
N565_RS04345	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
N565_RS04360	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
N565_RS04365	COG1757	Na H antiporter
N565_RS04370	COG4221	oxidoreductase activity
N565_RS04380	COG1049	propionate catabolic process, 2-methylcitrate cycle
N565_RS04385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
N565_RS04395	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N565_RS04395	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N565_RS04405	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
N565_RS04430	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N565_RS04435	COG1408	metallophosphoesterase
N565_RS04440	COG0688	phosphatidylethanolamine metabolic process
N565_RS04485	COG0681	Belongs to the peptidase S26 family
N565_RS04490	COG0303	'Molybdopterin
N565_RS04505	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
N565_RS04505	COG0512	Glutamine amidotransferase of anthranilate synthase
N565_RS04510	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
N565_RS04515	COG0582	viral genome integration into host DNA
N565_RS04525	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
N565_RS04560	COG3258	Cytochrome c
N565_RS04585	COG2404	hydrolase activity, acting on ester bonds
N565_RS04590	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
N565_RS04595	COG1959	2 iron, 2 sulfur cluster binding
N565_RS04600	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
N565_RS04605	COG1196	nuclear chromosome segregation
N565_RS04605	COG1674	ftsk spoiiie
N565_RS04610	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N565_RS04625	COG0488	(ABC) transporter
N565_RS04630	COG5002	protein histidine kinase activity
N565_RS04635	COG0745	RESPONSE REGULATOR receiver
N565_RS04640	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
N565_RS04650	COG0539	negative regulation of cytoplasmic translation
N565_RS04650	COG1185	polyribonucleotide nucleotidyltransferase activity
N565_RS04655	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
N565_RS04660	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
N565_RS04665	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
N565_RS04665	COG0072	phenylalanine-tRNA ligase activity
N565_RS04670	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
N565_RS04675	COG0537	adenosine 5'-monophosphoramidase activity
N565_RS04690	COG0765	amino acid transport
N565_RS04700	COG1115	amino acid carrier protein
N565_RS04705	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
N565_RS04710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
N565_RS04735	COG1999	signal sequence binding
N565_RS04740	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
N565_RS04745	COG0776	regulation of translation
N565_RS04765	COG1966	Carbon starvation protein
N565_RS04770	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
N565_RS04775	COG0765	amino acid transport
N565_RS04780	COG0765	amino acid transport
N565_RS04785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N565_RS04790	COG1126	abc transporter atp-binding protein
N565_RS04795	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
N565_RS04800	COG2201	protein-glutamate methylesterase activity
N565_RS04815	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
N565_RS04825	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
N565_RS04830	COG0012	GTP binding
N565_RS04835	COG0165	Argininosuccinate lyase
N565_RS04840	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
N565_RS04845	COG0511	ligase activity, forming carbon-carbon bonds
N565_RS04845	COG5016	pyruvate
N565_RS04850	COG0733	neurotransmitter:sodium symporter activity
N565_RS04855	COG0733	neurotransmitter:sodium symporter activity
N565_RS04860	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
N565_RS04920	COG0765	amino acid transport
N565_RS04930	COG0653	protein targeting
N565_RS04935	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
N565_RS04945	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
N565_RS04960	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
N565_RS04975	COG0840	transmembrane signaling receptor activity
N565_RS04985	COG0138	bifunctional purine biosynthesis protein purh
N565_RS04990	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
N565_RS04995	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
N565_RS05000	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
N565_RS05010	COG0706	membrane insertase activity
N565_RS05015	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
N565_RS05025	COG0230	Belongs to the bacterial ribosomal protein bL34 family
N565_RS05045	COG0824	Thioesterase
N565_RS05090	COG0500	methyltransferase
N565_RS05110	COG2195	Cleaves the N-terminal amino acid of tripeptides
N565_RS05115	COG0477	Major facilitator Superfamily
N565_RS05120	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
N565_RS05130	COG3022	response to hydroperoxide
N565_RS05135	COG1473	amidohydrolase
N565_RS05145	COG2807	transmembrane transport
N565_RS05165	COG0247	lactate metabolic process
N565_RS05165	COG2181	nitrate reductase activity
N565_RS05170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
N565_RS05180	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
N565_RS05185	COG0113	porphobilinogen synthase activity
N565_RS05190	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
N565_RS05195	COG0357	Ribosomal RNA small subunit methyltransferase G
N565_RS05205	COG2855	membrane
N565_RS05210	COG0583	DNA-binding transcription factor activity
N565_RS05215	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
N565_RS05235	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N565_RS05240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N565_RS05260	COG0343	queuine tRNA-ribosyltransferase activity
N565_RS05280	COG1333	cytochrome c biogenesis protein
N565_RS05280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
N565_RS05330	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
N565_RS05335	COG2204	response regulator
N565_RS05350	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
N565_RS05365	COG0481	GTPase activity
N565_RS05390	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
N565_RS05400	COG0439	Biotin carboxylase
N565_RS05405	COG0772	Belongs to the SEDS family
N565_RS05430	COG0352	thiamine-phosphate diphosphorylase activity
N565_RS05435	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N565_RS05440	COG2022	thiamine diphosphate biosynthetic process
N565_RS05455	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
N565_RS05475	COG1193	negative regulation of DNA recombination
N565_RS05505	COG0517	IMP dehydrogenase activity
N565_RS05505	COG0516	GMP reductase activity
N565_RS05525	COG1058	Belongs to the CinA family
N565_RS05525	COG1546	Belongs to the CinA family
N565_RS05530	COG0456	acetyltransferase
N565_RS05535	COG0778	Nitroreductase
N565_RS05540	COG0778	Nitroreductase
N565_RS05550	COG0750	zinc metalloprotease
N565_RS05555	COG2990	Protein conserved in bacteria
N565_RS05560	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
N565_RS05570	COG0360	Binds together with S18 to 16S ribosomal RNA
N565_RS05575	COG0629	single-stranded DNA binding
N565_RS05580	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
N565_RS05585	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
N565_RS05595	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
N565_RS05600	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
N565_RS05625	COG0352	thiamine-phosphate diphosphorylase activity
N565_RS05645	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
N565_RS05655	COG0739	heme binding
N565_RS05660	COG0285	dihydrofolate synthase activity
N565_RS05675	COG0495	leucyl-tRNA aminoacylation
N565_RS05680	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N565_RS05685	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
N565_RS05690	COG1862	Preprotein translocase
N565_RS05695	COG0815	Transfers the fatty acyl group on membrane lipoproteins
N565_RS05700	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
N565_RS05705	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
N565_RS05710	COG0540	Belongs to the ATCase OTCase family
N565_RS05725	COG0210	DNA helicase
N565_RS05745	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
N565_RS05760	COG0542	response to heat
N565_RS05765	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
N565_RS05775	COG2095	MarC family integral membrane protein
N565_RS05780	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
N565_RS05785	COG2833	Protein of unknown function (DUF455)
N565_RS05790	COG1183	phosphatidylcholine synthase activity
N565_RS05800	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
N565_RS05805	COG2264	protein methyltransferase activity
N565_RS05810	COG0745	RESPONSE REGULATOR receiver
N565_RS05820	COG1086	Polysaccharide biosynthesis protein
N565_RS05825	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N565_RS05835	COG0110	maltose O-acetyltransferase activity
N565_RS05840	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
N565_RS05845	COG0438	transferase activity, transferring glycosyl groups
N565_RS05850	COG1287	oligosaccharyl transferase activity
N565_RS05855	COG0438	transferase activity, transferring glycosyl groups
N565_RS05860	COG1215	transferase activity, transferring glycosyl groups
N565_RS05865	COG0438	transferase activity, transferring glycosyl groups
N565_RS05870	COG1132	(ABC) transporter
N565_RS05875	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
N565_RS05885	COG0859	PFAM glycosyl transferase family 9
N565_RS05890	COG1560	Kdo2-lipid A biosynthetic process
N565_RS05895	COG0463	Glycosyl transferase, family 2
N565_RS05900	COG1216	Glycosyl transferase, family 2
N565_RS05900	COG1442	glycosyl transferase family 8
N565_RS05910	COG1216	Glycosyl transferase, family 2
N565_RS05910	COG1442	glycosyl transferase family 8
N565_RS05915	COG1216	Glycosyl transferase, family 2
N565_RS05915	COG1442	glycosyl transferase family 8
N565_RS05925	COG2089	acid synthase
N565_RS05950	COG1216	Glycosyl transferase, family 2
N565_RS05960	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N565_RS05965	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
N565_RS05965	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
N565_RS05970	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N565_RS05975	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N565_RS05990	COG2217	Heavy metal translocating P-type atpase
N565_RS05995	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
N565_RS06000	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
N565_RS06005	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
N565_RS06010	COG2217	Heavy metal translocating P-type atpase
N565_RS06030	COG3610	response to peptide
N565_RS06040	COG0039	L-malate dehydrogenase activity
N565_RS06045	COG0586	Pfam SNARE associated Golgi protein
N565_RS06060	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
N565_RS06080	COG0018	arginyl-trna synthetase
N565_RS06085	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
N565_RS06090	COG0194	GDP metabolic process
N565_RS06100	COG1684	flagellar biosynthetic protein fliR
N565_RS06110	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
N565_RS06115	COG0052	Belongs to the universal ribosomal protein uS2 family
N565_RS06120	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
N565_RS06130	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
N565_RS06135	COG0723	plastoquinol--plastocyanin reductase activity
N565_RS06140	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
N565_RS06165	COG1301	dicarboxylic acid transport
N565_RS06180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
N565_RS06190	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
N565_RS06195	COG1854	S-ribosylhomocysteine lyase activity
N565_RS06215	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
N565_RS06230	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
N565_RS06235	COG0552	protein localization to endoplasmic reticulum
N565_RS06250	COG1418	mRNA catabolic process
N565_RS06265	COG1295	ribonuclease BN
N565_RS06270	COG0277	FAD linked oxidase domain protein
N565_RS06280	COG0739	heme binding
N565_RS06290	COG1496	oxidoreductase activity
N565_RS06305	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
N565_RS06310	COG0459	protein refolding
N565_RS06315	COG0642	Histidine kinase
N565_RS06320	COG0745	RESPONSE REGULATOR receiver
N565_RS06340	COG0642	Histidine kinase
N565_RS06345	COG0745	RESPONSE REGULATOR receiver
N565_RS06350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
N565_RS06355	COG0484	heat shock protein binding
N565_RS06360	COG0789	Transcriptional regulator
N565_RS06365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
N565_RS06365	COG0475	glutathione-regulated potassium exporter activity
N565_RS06375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
N565_RS06380	COG0751	glycine-tRNA ligase activity
N565_RS06385	COG0739	heme binding
N565_RS06395	COG0248	Ppx GppA phosphatase
N565_RS06400	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
N565_RS06405	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
N565_RS06415	COG2814	Major facilitator Superfamily
N565_RS06425	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
N565_RS06430	COG0731	radical SAM domain protein
N565_RS06440	COG0322	excinuclease ABC activity
N565_RS06450	COG0519	Catalyzes the synthesis of GMP from XMP
N565_RS06450	COG0518	GMP synthase (glutamine-hydrolyzing) activity
N565_RS06475	COG1185	polyribonucleotide nucleotidyltransferase activity
N565_RS06485	COG1942	4-Oxalocrotonate Tautomerase
N565_RS06500	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
N565_RS06505	COG4773	Receptor
N565_RS06510	COG0484	heat shock protein binding
N565_RS06515	COG0745	RESPONSE REGULATOR receiver
N565_RS06520	COG0642	Histidine kinase
N565_RS06525	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
N565_RS06530	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
N565_RS06535	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
N565_RS06540	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
N565_RS06545	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
N565_RS06550	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
N565_RS06550	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
N565_RS06565	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
N565_RS06570	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
N565_RS06575	COG1758	RNA polymerase activity
N565_RS06580	COG0528	UMP kinase activity
N565_RS06595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
N565_RS06600	COG0220	tRNA (guanine-N7-)-methyltransferase activity
N565_RS06610	COG0564	pseudouridine synthase activity
N565_RS06615	COG0772	Belongs to the SEDS family
N565_RS06625	COG0582	viral genome integration into host DNA
N565_RS06640	COG0863	Belongs to the N(4) N(6)-methyltransferase family
N565_RS06890	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
N565_RS06895	COG0569	domain protein
N565_RS06900	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
N565_RS06905	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
N565_RS06910	COG0280	phosphate acetyltransferase
N565_RS06910	COG0281	malic enzyme
N565_RS06915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
N565_RS06925	COG0439	Biotin carboxylase
N565_RS06930	COG0511	ligase activity, forming carbon-carbon bonds
N565_RS06935	COG0717	Belongs to the dCTP deaminase family
N565_RS06940	COG1086	Polysaccharide biosynthesis protein
N565_RS06945	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N565_RS06950	COG4310	Domain of unknown function (DUF2172)
N565_RS06985	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
N565_RS07025	COG1083	cytidylyl-transferase
N565_RS07030	COG3980	spore coat polysaccharide biosynthesis protein
N565_RS07035	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
N565_RS07040	COG0107	imidazoleglycerol-phosphate synthase activity
N565_RS07045	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
N565_RS07055	COG2089	acid synthase
N565_RS07060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N565_RS07065	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
N565_RS07095	COG2089	acid synthase
N565_RS07100	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
N565_RS07105	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
N565_RS07115	COG1083	cytidylyl-transferase
N565_RS07120	COG1028	Short-chain dehydrogenase reductase Sdr
N565_RS07145	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N565_RS07150	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
N565_RS07170	COG2165	general secretion pathway protein
N565_RS07175	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
N565_RS07185	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
N565_RS07190	COG0575	Belongs to the CDS family
N565_RS07200	COG1293	RNA-binding protein homologous to eukaryotic snRNP
N565_RS07210	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
N565_RS07215	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N565_RS07220	COG4605	iron ion homeostasis
N565_RS07225	COG4604	ABC transporter, ATP-binding protein
N565_RS07230	COG4607	ABC-type enterochelin transport system periplasmic component
N565_RS07245	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
N565_RS07250	COG3005	denitrification pathway
N565_RS07255	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
N565_RS07265	COG2255	four-way junction helicase activity
N565_RS07270	COG0628	permease
N565_RS07275	COG0114	fumarate hydratase activity
N565_RS07285	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
N565_RS07295	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
N565_RS07300	COG2252	PERMEase
N565_RS07310	COG2853	Lipoprotein
N565_RS07325	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
N565_RS07330	COG2814	Major facilitator Superfamily
N565_RS07345	COG1921	L-seryl-tRNASec selenium transferase activity
N565_RS07350	COG3276	selenocysteine insertion sequence binding
N565_RS07365	COG0716	FMN binding
N565_RS07380	COG0753	catalase activity
N565_RS07390	COG2964	Protein conserved in bacteria
N565_RS07395	COG0251	oxidation-reduction process
N565_RS07400	COG3069	C4-dicarboxylate transmembrane transporter activity
N565_RS07405	COG3069	C4-dicarboxylate transmembrane transporter activity
N565_RS07410	COG3069	C4-dicarboxylate transmembrane transporter activity
N565_RS07435	COG1918	ferrous iron import across plasma membrane
N565_RS07445	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
N565_RS07450	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
N565_RS07455	COG0149	triose-phosphate isomerase activity
N565_RS07460	COG0126	phosphoglycerate kinase activity
N565_RS07465	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
N565_RS07490	COG1580	Controls the rotational direction of flagella during chemotaxis
N565_RS07495	COG0736	holo-[acyl-carrier-protein] synthase activity
N565_RS07505	COG2124	cytochrome p450
N565_RS07525	COG0529	Catalyzes the synthesis of activated sulfate
N565_RS07530	COG1213	nucleotidyl transferase
N565_RS07535	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
N565_RS07540	COG0574	Belongs to the PEP-utilizing enzyme family
N565_RS07540	COG3848	Pyruvate phosphate dikinase
N565_RS07545	COG2226	methyltransferase
N565_RS07570	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
N565_RS07590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
N565_RS07620	COG1216	Glycosyl transferase, family 2
N565_RS07635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
N565_RS07640	COG1216	Glycosyl transferase, family 2
N565_RS07645	COG0562	UDP-galactopyranose mutase
N565_RS07650	COG1442	glycosyl transferase family 8
N565_RS07650	COG1216	Glycosyl transferase, family 2
N565_RS07665	COG0517	IMP dehydrogenase activity
N565_RS07665	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
N565_RS07710	COG0037	tRNA processing
N565_RS07715	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
N565_RS07720	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
N565_RS07730	COG0585	pseudouridine synthase activity
N565_RS07735	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
N565_RS07755	COG1706	bacterial-type flagellum-dependent cell motility
N565_RS07760	COG3951	Flagellar rod assembly protein muramidase FlgJ
N565_RS07785	COG0730	response to heat
N565_RS07790	COG1459	type II secretion system
N565_RS07795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
N565_RS07825	COG0546	phosphoglycolate phosphatase activity
N565_RS07835	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
N565_RS07840	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
N565_RS07845	COG0210	DNA helicase
N565_RS07850	COG2887	Belongs to the helicase family. UvrD subfamily
N565_RS07895	COG0745	RESPONSE REGULATOR receiver
N565_RS07910	COG0505	Belongs to the CarA family
N565_RS07930	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
N565_RS07945	COG0425	Belongs to the sulfur carrier protein TusA family
N565_RS07950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
N565_RS07960	COG0709	Synthesizes selenophosphate from selenide and ATP
N565_RS07980	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
N565_RS07990	COG0437	4 iron, 4 sulfur cluster binding
N565_RS08000	COG3383	formate dehydrogenase (NAD+) activity
N565_RS08030	COG0314	molybdopterin synthase activity
N565_RS08035	COG0303	'Molybdopterin
N565_RS08040	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
N565_RS08050	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
N565_RS08065	COG3069	C4-dicarboxylate transmembrane transporter activity
N565_RS08070	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
N565_RS08075	COG0237	dephospho-CoA kinase activity
N565_RS08080	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
N565_RS08085	COG2992	FlgJ-related protein
N565_RS08095	COG0783	Belongs to the Dps family
N565_RS08100	COG0166	Belongs to the GPI family
N565_RS08110	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
N565_RS08115	COG3839	Belongs to the ABC transporter superfamily
N565_RS08120	COG4662	Binding-protein-dependent transport system inner membrane component
N565_RS08125	COG2998	abc-type tungstate transport system, permease component
N565_RS08130	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
N565_RS08135	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
N565_RS08140	COG1984	allophanate hydrolase subunit 2
N565_RS08150	COG2249	NAD(P)H dehydrogenase (quinone) activity
N565_RS08155	COG1733	regulation of RNA biosynthetic process
N565_RS08165	COG1064	alcohol dehydrogenase
N565_RS08170	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
N565_RS08190	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
N565_RS08195	COG2910	NAD(P)H-binding
N565_RS08200	COG1733	regulation of RNA biosynthetic process
N565_RS08210	COG0640	Transcriptional regulator
N565_RS08235	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N565_RS08240	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
N565_RS08250	COG0839	Belongs to the complex I subunit 6 family
N565_RS08260	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
N565_RS08285	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N565_RS08290	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N565_RS08295	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
N565_RS08300	COG4608	Belongs to the ABC transporter superfamily
N565_RS08310	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
N565_RS08315	COG0601	transmembrane transport
N565_RS08325	COG0277	FAD linked oxidase domain protein
N565_RS08335	COG4615	Cyclic peptide transporter
N565_RS08345	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
N565_RS08350	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
N565_RS08355	COG0257	Belongs to the bacterial ribosomal protein bL36 family
N565_RS08365	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
N565_RS08370	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
N565_RS08375	COG0202	RNA polymerase activity
N565_RS08380	COG0203	ribosomal protein L17
N565_RS08390	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
N565_RS08395	COG0131	Imidazoleglycerol-phosphate dehydratase
N565_RS08395	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
N565_RS08405	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
N565_RS08420	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
N565_RS08420	COG0140	phosphoribosyl-ATP diphosphatase activity
N565_RS08425	COG2171	N-acyltransferase activity
N565_RS08430	COG0489	protein tyrosine kinase activity
N565_RS08435	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
N565_RS08435	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
N565_RS08445	COG2046	Belongs to the sulfate adenylyltransferase family
N565_RS08450	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
N565_RS08455	COG0268	Binds directly to 16S ribosomal RNA
N565_RS08460	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
N565_RS08465	COG0748	coenzyme F420 binding
N565_RS08470	COG4771	TonB-dependent receptor
N565_RS08475	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
N565_RS08480	COG1120	ATPase activity
N565_RS08485	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
N565_RS08500	COG1194	a g-specific adenine glycosylase
N565_RS08530	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N565_RS08530	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
N565_RS08540	COG1760	l-serine dehydratase
N565_RS08545	COG0814	amino acid
N565_RS08560	COG0811	peptide transport
N565_RS08565	COG0848	biopolymer transport protein
N565_RS08590	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
N565_RS08595	COG0571	ribonuclease III activity
N565_RS08600	COG0328	RNA-DNA hybrid ribonuclease activity
N565_RS08610	COG0358	DNA primase activity
N565_RS08625	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
N565_RS08630	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
N565_RS08645	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
N565_RS08650	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
N565_RS08655	COG1127	ABC transporter
N565_RS08665	COG3218	ABC-type transport auxiliary lipoprotein component
N565_RS08665	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
N565_RS08675	COG0024	Methionine aminopeptidase
N565_RS08680	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
N565_RS08685	COG0791	NLP P60 protein
N565_RS08690	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N565_RS08695	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
N565_RS08705	COG0672	)-iron permease
N565_RS08730	COG1136	(ABC) transporter
N565_RS08785	COG1793	dna ligase
N565_RS08800	COG0148	phosphopyruvate hydratase activity
N565_RS08805	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
N565_RS08810	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
N565_RS08815	COG1987	bacterial-type flagellum assembly
N565_RS08820	COG0812	UDP-N-acetylmuramate dehydrogenase activity
N565_RS08845	COG1218	3'(2'),5'-bisphosphate nucleotidase
N565_RS08850	COG0372	Belongs to the citrate synthase family
N565_RS08860	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
N565_RS08865	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
N565_RS08875	COG0201	protein transport
N565_RS08880	COG0200	Binds to the 23S rRNA
N565_RS08885	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
N565_RS08890	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
N565_RS08895	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
N565_RS08900	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
N565_RS08905	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
N565_RS08910	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
N565_RS08915	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
N565_RS08920	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
N565_RS08925	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
N565_RS08930	COG0255	Belongs to the universal ribosomal protein uL29 family
N565_RS08935	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
N565_RS08940	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
N565_RS08950	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
N565_RS08960	COG0089	rRNA binding
N565_RS08965	COG0088	Forms part of the polypeptide exit tunnel
N565_RS08970	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
N565_RS08975	COG0051	transcription antitermination factor activity, RNA binding
N565_RS08980	COG1187	pseudouridine synthase activity
N565_RS08985	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
N565_RS08990	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
N565_RS09000	COG0820	rRNA (adenine-C2-)-methyltransferase activity
N565_RS09040	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
N565_RS09045	COG0473	3-isopropylmalate dehydrogenase activity
N565_RS09050	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
N565_RS09070	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
N565_RS09080	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
N565_RS09095	COG1749	Flagellar hook protein flgE
N565_RS09100	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
N565_RS09110	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex