locus-tag	class	description
PJ18_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
PJ18_RS00010	COG0592	DNA-directed DNA polymerase activity
PJ18_RS00015	COG0187	DNA topoisomerase II activity
PJ18_RS00030	COG2056	Na+-H+ antiporter family
PJ18_RS00035	COG0070	glutamate synthase
PJ18_RS00035	COG0069	glutamate synthase activity
PJ18_RS00035	COG0067	glutamate synthase
PJ18_RS00040	COG0493	'glutamate synthase
PJ18_RS00045	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
PJ18_RS00055	COG1592	Rubrerythrin
PJ18_RS00060	COG0129	dihydroxy-acid dehydratase activity
PJ18_RS00065	COG3477	response to acidic pH
PJ18_RS00075	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
PJ18_RS00095	COG1858	cytochrome C peroxidase
PJ18_RS00100	COG0179	Fumarylacetoacetate (FAA) hydrolase
PJ18_RS00105	COG0564	pseudouridine synthase activity
PJ18_RS00110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
PJ18_RS00115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PJ18_RS00120	COG1823	symporter activity
PJ18_RS00130	COG0504	CTP synthase activity
PJ18_RS00140	COG0252	asparaginase activity
PJ18_RS00200	COG2814	Major facilitator Superfamily
PJ18_RS00220	COG1217	gtp-binding protein TYPA
PJ18_RS00235	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
PJ18_RS00260	COG0471	metal ion transport
PJ18_RS00275	COG0471	metal ion transport
PJ18_RS00310	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PJ18_RS00310	COG1776	CheC inhibitor of MCP methylation
PJ18_RS00315	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PJ18_RS00320	COG1191	sigma factor activity
PJ18_RS00330	COG0455	bacterial-type flagellum organization
PJ18_RS00335	COG1419	protein localization to endoplasmic reticulum
PJ18_RS00340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
PJ18_RS00345	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
PJ18_RS00350	COG0402	S-adenosylhomocysteine deaminase activity
PJ18_RS00355	COG0616	signal peptide processing
PJ18_RS00385	COG1139	Iron-sulfur cluster binding protein
PJ18_RS00390	COG0247	lactate metabolic process
PJ18_RS00405	COG3021	interspecies interaction between organisms
PJ18_RS00420	COG1271	oxidase subunit
PJ18_RS00425	COG1294	oxidase, subunit
PJ18_RS00435	COG1794	racemase activity, acting on amino acids and derivatives
PJ18_RS00440	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
PJ18_RS00445	COG1027	Aspartate ammonia-lyase
PJ18_RS00450	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
PJ18_RS00480	COG0261	This protein binds to 23S rRNA in the presence of protein L20
PJ18_RS00485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
PJ18_RS00490	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
PJ18_RS00500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
PJ18_RS00505	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
PJ18_RS00505	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
PJ18_RS00510	COG1192	Involved in chromosome partitioning
PJ18_RS00515	COG1475	DNA binding
PJ18_RS00525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
PJ18_RS00530	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PJ18_RS00540	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
PJ18_RS00545	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
PJ18_RS00550	COG0355	proton-transporting ATP synthase activity, rotational mechanism
PJ18_RS00555	COG0811	peptide transport
PJ18_RS00560	COG0848	biopolymer transport protein
PJ18_RS00570	COG0823	Involved in the tonB-independent uptake of proteins
PJ18_RS00575	COG2885	chlorophyll binding
PJ18_RS00585	COG1047	Peptidyl-prolyl cis-trans
PJ18_RS00590	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
PJ18_RS00595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
PJ18_RS00600	COG0037	tRNA processing
PJ18_RS00625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
PJ18_RS00635	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
PJ18_RS00640	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
PJ18_RS00645	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
PJ18_RS00655	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
PJ18_RS00670	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
PJ18_RS00680	COG0083	homoserine kinase activity
PJ18_RS00705	COG1401	restriction endodeoxyribonuclease activity
PJ18_RS00715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
PJ18_RS00720	COG1121	(ABC) transporter
PJ18_RS00730	COG0840	transmembrane signaling receptor activity
PJ18_RS00735	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PJ18_RS00745	COG0418	dihydroorotase activity
PJ18_RS00755	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
PJ18_RS00760	COG2194	sulfuric ester hydrolase activity
PJ18_RS00765	COG0708	Exodeoxyribonuclease III
PJ18_RS00775	COG2921	Belongs to the UPF0250 family
PJ18_RS00780	COG0315	cyclic pyranopterin monophosphate synthase activity
PJ18_RS00790	COG0477	Major facilitator Superfamily
PJ18_RS00810	COG0840	transmembrane signaling receptor activity
PJ18_RS00810	COG3290	protein histidine kinase activity
PJ18_RS00815	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
PJ18_RS00820	COG0291	Belongs to the bacterial ribosomal protein bL35 family
PJ18_RS00845	COG0668	transmembrane transport
PJ18_RS00850	COG0288	reversible hydration of carbon dioxide
PJ18_RS00855	COG0670	Belongs to the BI1 family
PJ18_RS00860	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
PJ18_RS00865	COG0233	cytoplasmic translational termination
PJ18_RS00870	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
PJ18_RS00880	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
PJ18_RS00895	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
PJ18_RS00900	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
PJ18_RS00915	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
PJ18_RS00950	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
PJ18_RS00955	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
PJ18_RS00960	COG1968	undecaprenyl-diphosphatase activity
PJ18_RS00965	COG1297	OPT oligopeptide transporter protein
PJ18_RS00970	COG2851	Citrate transporter
PJ18_RS00995	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
PJ18_RS00995	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
PJ18_RS01000	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
PJ18_RS01005	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
PJ18_RS01010	COG1157	protein secretion by the type III secretion system
PJ18_RS01015	COG0302	gtp cyclohydrolase
PJ18_RS01020	COG0544	peptidyl-prolyl cis-trans isomerase activity
PJ18_RS01030	COG0242	peptide deformylase activity
PJ18_RS01035	COG0606	chelatase, subunit chli
PJ18_RS01045	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
PJ18_RS01045	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
PJ18_RS01050	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
PJ18_RS01055	COG0861	Integral membrane protein TerC family
PJ18_RS01060	COG2824	Alkylphosphonate utilization operon protein PhnA
PJ18_RS01070	COG1253	flavin adenine dinucleotide binding
PJ18_RS01075	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
PJ18_RS01085	COG0848	biopolymer transport protein
PJ18_RS01090	COG0811	peptide transport
PJ18_RS01095	COG1629	transport
PJ18_RS01095	COG4206	TonB-dependent receptor
PJ18_RS01110	COG1840	ABC-type Fe3 transport system, periplasmic component
PJ18_RS01135	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
PJ18_RS01150	COG1971	Probably functions as a manganese efflux pump
PJ18_RS01175	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
PJ18_RS01180	COG0602	queuosine metabolic process
PJ18_RS01200	COG1385	rRNA (uridine-N3-)-methyltransferase activity
PJ18_RS01205	COG0254	rRNA binding
PJ18_RS01210	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
PJ18_RS01215	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
PJ18_RS01230	COG0436	Aminotransferase
PJ18_RS01235	COG0460	homoserine dehydrogenase
PJ18_RS01245	COG3118	belongs to the thioredoxin family
PJ18_RS01250	COG0492	ferredoxin-NADP+ reductase activity
PJ18_RS01265	COG0428	transporter
PJ18_RS01270	COG0243	molybdopterin cofactor binding
PJ18_RS01290	COG0330	HflC and HflK could
PJ18_RS01300	COG1942	4-Oxalocrotonate Tautomerase
PJ18_RS01305	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
PJ18_RS01310	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
PJ18_RS01315	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
PJ18_RS01320	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PJ18_RS01325	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
PJ18_RS01330	COG1077	Cell shape determining protein MreB Mrl
PJ18_RS01340	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
PJ18_RS01360	COG0835	chemotaxis
PJ18_RS01365	COG2198	Histidine kinase
PJ18_RS01365	COG0784	Response regulator, receiver
PJ18_RS01365	COG0643	Histidine kinase
PJ18_RS01370	COG0784	Response regulator, receiver
PJ18_RS01370	COG0835	chemotaxis
PJ18_RS01385	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
PJ18_RS01410	COG0454	-acetyltransferase
PJ18_RS01455	COG4106	trans-aconitate 2-methyltransferase activity
PJ18_RS01460	COG2830	Protein of unknown function (DUF452)
PJ18_RS01470	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
PJ18_RS01475	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
PJ18_RS01480	COG2076	Multidrug Resistance protein
PJ18_RS01505	COG0019	diaminopimelate decarboxylase activity
PJ18_RS01520	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
PJ18_RS01530	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PJ18_RS01540	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
PJ18_RS01555	COG2226	methyltransferase
PJ18_RS01560	COG1570	exodeoxyribonuclease VII activity
PJ18_RS01565	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
PJ18_RS01570	COG0251	oxidation-reduction process
PJ18_RS01575	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PJ18_RS01580	COG0416	fatty acid biosynthetic process
PJ18_RS01585	COG0333	Belongs to the bacterial ribosomal protein bL32 family
PJ18_RS01595	COG0105	UTP biosynthetic process
PJ18_RS01605	COG0450	alkyl hydroperoxide reductase
PJ18_RS01610	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PJ18_RS01615	COG1360	Flagellar Motor Protein
PJ18_RS01620	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
PJ18_RS01630	COG0477	Major facilitator Superfamily
PJ18_RS01640	COG1238	metal cluster binding
PJ18_RS01660	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
PJ18_RS01665	COG0730	response to heat
PJ18_RS01680	COG0512	Glutamine amidotransferase of anthranilate synthase
PJ18_RS01680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PJ18_RS01690	COG0133	tryptophan synthase activity
PJ18_RS01705	COG1776	CheC inhibitor of MCP methylation
PJ18_RS01705	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
PJ18_RS01720	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
PJ18_RS01725	COG0745	RESPONSE REGULATOR receiver
PJ18_RS01745	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
PJ18_RS01750	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
PJ18_RS01755	COG1981	membrane
PJ18_RS01760	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PJ18_RS01770	COG1538	Outer membrane efflux protein
PJ18_RS01780	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PJ18_RS01795	COG0828	Belongs to the bacterial ribosomal protein bS21 family
PJ18_RS01805	COG0754	glutathionylspermidine amidase activity
PJ18_RS01810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
PJ18_RS01815	COG1666	GTP binding
PJ18_RS01830	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PJ18_RS01835	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
PJ18_RS01840	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
PJ18_RS01860	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
PJ18_RS01890	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
PJ18_RS01905	COG0469	pyruvate kinase activity
PJ18_RS01910	COG0579	oxidoreductase
PJ18_RS01915	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
PJ18_RS01950	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
PJ18_RS01955	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
PJ18_RS01970	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
PJ18_RS01990	COG1053	succinate dehydrogenase
PJ18_RS01995	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PJ18_RS02045	COG2353	YceI-like domain
PJ18_RS02075	COG0488	(ABC) transporter
PJ18_RS02090	COG1739	Uncharacterized protein family UPF0029
PJ18_RS02130	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
PJ18_RS02135	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
PJ18_RS02140	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
PJ18_RS02150	COG1028	Short-chain dehydrogenase reductase Sdr
PJ18_RS02160	COG1053	succinate dehydrogenase
PJ18_RS02165	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
PJ18_RS02170	COG2048	Heterodisulfide reductase, subunit B
PJ18_RS02175	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
PJ18_RS02180	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
PJ18_RS02185	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
PJ18_RS02190	COG0825	malonyl-CoA metabolic process
PJ18_RS02200	COG0494	nUDIX hydrolase
PJ18_RS02215	COG0227	Belongs to the bacterial ribosomal protein bL28 family
PJ18_RS02220	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
PJ18_RS02230	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
PJ18_RS02250	COG2121	Domain of unknown function (DUF374)
PJ18_RS02255	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PJ18_RS02265	COG0195	Participates in both transcription termination and antitermination
PJ18_RS02275	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
PJ18_RS02280	COG0612	Peptidase, M16
PJ18_RS02285	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
PJ18_RS02290	COG2346	COG2346, Truncated hemoglobins
PJ18_RS02305	COG0765	amino acid transport
PJ18_RS02335	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
PJ18_RS02340	COG0267	Belongs to the bacterial ribosomal protein bL33 family
PJ18_RS02355	COG0250	Participates in transcription elongation, termination and antitermination
PJ18_RS02360	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
PJ18_RS02365	COG0081	regulation of translation
PJ18_RS02370	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
PJ18_RS02375	COG0222	ribosome binding
PJ18_RS02380	COG0085	RNA polymerase activity
PJ18_RS02385	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
PJ18_RS02395	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PJ18_RS02405	COG2721	sulfolactate sulfo-lyase activity
PJ18_RS02410	COG2271	Major facilitator Superfamily
PJ18_RS02415	COG1028	Short-chain dehydrogenase reductase Sdr
PJ18_RS02420	COG0738	Major facilitator superfamily
PJ18_RS02435	COG1012	belongs to the aldehyde dehydrogenase family
PJ18_RS02440	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
PJ18_RS02445	COG0049	tRNA binding
PJ18_RS02480	COG0134	indole-3-glycerol-phosphate synthase activity
PJ18_RS02490	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
PJ18_RS02505	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
PJ18_RS02510	COG0673	inositol 2-dehydrogenase activity
PJ18_RS02520	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
PJ18_RS02525	COG0424	maF-like protein
PJ18_RS02535	COG0542	response to heat
PJ18_RS02540	COG1937	Protein conserved in bacteria
PJ18_RS02545	COG0793	Belongs to the peptidase S41A family
PJ18_RS02550	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
PJ18_RS02555	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PJ18_RS02560	COG0047	phosphoribosylformylglycinamidine synthase activity
PJ18_RS02570	COG0204	Acyl-transferase
PJ18_RS02575	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
PJ18_RS02580	COG0326	Molecular chaperone. Has ATPase activity
PJ18_RS02585	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
PJ18_RS02615	COG1677	Flagellar hook-basal body complex protein FliE
PJ18_RS02620	COG1558	bacterial-type flagellum-dependent cell motility
PJ18_RS02625	COG1815	bacterial-type flagellum-dependent cell motility
PJ18_RS02645	COG0039	L-malate dehydrogenase activity
PJ18_RS02655	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
PJ18_RS02665	COG0674	pyruvate-flavodoxin oxidoreductase activity
PJ18_RS02665	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
PJ18_RS02670	COG1013	pyruvate-flavodoxin oxidoreductase activity
PJ18_RS02690	COG0142	geranyltranstransferase activity
PJ18_RS02695	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
PJ18_RS02700	COG0442	prolyl-tRNA aminoacylation
PJ18_RS02710	COG0181	hydroxymethylbilane synthase activity
PJ18_RS02715	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
PJ18_RS02725	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
PJ18_RS02740	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
PJ18_RS02770	COG1289	transmembrane transporter activity
PJ18_RS02775	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
PJ18_RS02780	COG0492	ferredoxin-NADP+ reductase activity
PJ18_RS02795	COG0305	Participates in initiation and elongation during chromosome replication
PJ18_RS02810	COG4735	regulation of single-species biofilm formation
PJ18_RS02860	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PJ18_RS02860	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PJ18_RS02865	COG1610	YqeY-like protein
PJ18_RS02870	COG0028	Belongs to the TPP enzyme family
PJ18_RS02875	COG0440	acetolactate synthase activity
PJ18_RS02885	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
PJ18_RS02890	COG0805	protein transport
PJ18_RS02900	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PJ18_RS02905	COG0494	nUDIX hydrolase
PJ18_RS02910	COG0527	aspartate kinase activity
PJ18_RS02925	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
PJ18_RS02930	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
PJ18_RS02945	COG0196	riboflavin kinase activity
PJ18_RS02950	COG2890	protein-(glutamine-N5) methyltransferase activity
PJ18_RS02965	COG2860	membrane
PJ18_RS02975	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
PJ18_RS02980	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PJ18_RS02985	COG0191	fructose-bisphosphate aldolase activity
PJ18_RS03005	COG0733	neurotransmitter:sodium symporter activity
PJ18_RS03010	COG2258	MOSC domain
PJ18_RS03025	COG1473	amidohydrolase
PJ18_RS03030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
PJ18_RS03035	COG0577	efflux transmembrane transporter activity
PJ18_RS03035	COG1136	(ABC) transporter
PJ18_RS03040	COG1538	Outer membrane efflux protein
PJ18_RS03055	COG1696	Membrane protein involved in D-alanine export
PJ18_RS03060	COG1528	Iron-storage protein
PJ18_RS03065	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
PJ18_RS03070	COG0573	inorganic phosphate transmembrane transporter activity
PJ18_RS03075	COG0581	inorganic phosphate transmembrane transporter activity
PJ18_RS03090	COG0534	Mate efflux family protein
PJ18_RS03105	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
PJ18_RS03115	COG0298	carbon dioxide binding
PJ18_RS03120	COG0409	Hydrogenase expression formation protein
PJ18_RS03125	COG0309	Hydrogenase expression formation protein (HypE)
PJ18_RS03130	COG0375	protein maturation
PJ18_RS03145	COG0557	exoribonuclease II activity
PJ18_RS03150	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
PJ18_RS03160	COG0758	DNA mediated transformation
PJ18_RS03175	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PJ18_RS03180	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
PJ18_RS03185	COG0563	adenylate kinase activity
PJ18_RS03190	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
PJ18_RS03195	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
PJ18_RS03200	COG0497	DNA recombination
PJ18_RS03210	COG0084	hydrolase, TatD family'
PJ18_RS03215	COG0791	NLP P60 protein
PJ18_RS03215	COG1388	LysM domain
PJ18_RS03220	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
PJ18_RS03240	COG0218	Necessary for normal cell division and for the maintenance of normal septation
PJ18_RS03285	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
PJ18_RS03290	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
PJ18_RS03295	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
PJ18_RS03305	COG0137	argininosuccinate synthase activity
PJ18_RS03310	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
PJ18_RS03315	COG0802	atpase or kinase
PJ18_RS03320	COG1137	ATPase activity
PJ18_RS03325	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
PJ18_RS03330	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
PJ18_RS03355	COG2205	protein histidine kinase activity
PJ18_RS03380	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
PJ18_RS03390	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
PJ18_RS03400	COG0280	phosphate acetyltransferase
PJ18_RS03425	COG0275	rRNA processing
PJ18_RS03430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
PJ18_RS03435	COG0849	cell division
PJ18_RS03440	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
PJ18_RS03445	COG4786	Flagellar basal body rod
PJ18_RS03450	COG4786	Flagellar basal body rod
PJ18_RS03455	COG0174	glutamine synthetase
PJ18_RS03465	COG0826	peptidase U32
PJ18_RS03470	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
PJ18_RS03480	COG0752	glycyl-tRNA synthetase alpha subunit
PJ18_RS03485	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
PJ18_RS03495	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PJ18_RS03495	COG1519	Transferase
PJ18_RS03500	COG0564	pseudouridine synthase activity
PJ18_RS03505	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
PJ18_RS03510	COG0228	four-way junction DNA binding
PJ18_RS03515	COG1837	Belongs to the UPF0109 family
PJ18_RS03520	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
PJ18_RS03525	COG0336	Belongs to the RNA methyltransferase TrmD family
PJ18_RS03540	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
PJ18_RS03545	COG1393	Belongs to the ArsC family
PJ18_RS03550	COG0587	DNA-directed DNA polymerase activity
PJ18_RS03555	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
PJ18_RS03560	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PJ18_RS03570	COG2890	protein-(glutamine-N5) methyltransferase activity
PJ18_RS03575	COG0501	Belongs to the peptidase M48B family
PJ18_RS03585	COG0521	Mo-molybdopterin cofactor biosynthetic process
PJ18_RS03590	COG0598	Magnesium transport protein CorA
PJ18_RS03620	COG3842	ATPase activity
PJ18_RS03715	COG0675	Transposase, IS605 OrfB family
PJ18_RS03725	COG4771	TonB-dependent receptor
PJ18_RS03730	COG1420	regulation of RNA biosynthetic process
PJ18_RS03735	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
PJ18_RS03740	COG0443	Heat shock 70 kDa protein
PJ18_RS03755	COG0436	Aminotransferase
PJ18_RS03760	COG1045	serine acetyltransferase
PJ18_RS03765	COG1166	arginine decarboxylase activity
PJ18_RS03780	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
PJ18_RS03785	COG0163	prenyltransferase activity
PJ18_RS03795	COG1464	Belongs to the NlpA lipoprotein family
PJ18_RS03800	COG1464	Belongs to the NlpA lipoprotein family
PJ18_RS03805	COG1464	Belongs to the NlpA lipoprotein family
PJ18_RS03810	COG2011	ABC-type metal ion transport system permease component
PJ18_RS03815	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PJ18_RS03830	COG0210	DNA helicase
PJ18_RS03840	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
PJ18_RS03850	COG0437	4 iron, 4 sulfur cluster binding
PJ18_RS03855	COG0348	domain, Protein
PJ18_RS03860	COG3043	anaerobic respiration
PJ18_RS03895	COG0788	formyltetrahydrofolate deformylase activity
PJ18_RS03900	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
PJ18_RS03910	COG0642	Histidine kinase
PJ18_RS03935	COG1181	Belongs to the D-alanine--D-alanine ligase family
PJ18_RS03940	COG0632	four-way junction helicase activity
PJ18_RS03950	COG0728	peptidoglycan biosynthetic process
PJ18_RS03955	COG0215	cysteine-tRNA ligase activity
PJ18_RS03960	COG1132	(ABC) transporter
PJ18_RS03965	COG0167	dihydroorotate dehydrogenase activity
PJ18_RS03970	COG0612	Peptidase, M16
PJ18_RS03975	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
PJ18_RS03980	COG1028	Short-chain dehydrogenase reductase Sdr
PJ18_RS03995	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
PJ18_RS04000	COG1663	tetraacyldisaccharide 4'-kinase activity
PJ18_RS04005	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
PJ18_RS04010	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
PJ18_RS04025	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PJ18_RS04040	COG1338	Plays a role in the flagellum-specific transport system
PJ18_RS04045	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
PJ18_RS04080	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
PJ18_RS04095	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
PJ18_RS04100	COG1757	Na H antiporter
PJ18_RS04105	COG4221	oxidoreductase activity
PJ18_RS04115	COG1049	propionate catabolic process, 2-methylcitrate cycle
PJ18_RS04120	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
PJ18_RS04130	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PJ18_RS04130	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PJ18_RS04140	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
PJ18_RS04165	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PJ18_RS04170	COG1408	metallophosphoesterase
PJ18_RS04175	COG0688	phosphatidylethanolamine metabolic process
PJ18_RS04220	COG0681	Belongs to the peptidase S26 family
PJ18_RS04225	COG0303	'Molybdopterin
PJ18_RS04240	COG0512	Glutamine amidotransferase of anthranilate synthase
PJ18_RS04240	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
PJ18_RS04245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
PJ18_RS04250	COG0582	viral genome integration into host DNA
PJ18_RS04260	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
PJ18_RS04295	COG3258	Cytochrome c
PJ18_RS04320	COG2404	hydrolase activity, acting on ester bonds
PJ18_RS04325	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
PJ18_RS04330	COG1959	2 iron, 2 sulfur cluster binding
PJ18_RS04335	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
PJ18_RS04340	COG1674	ftsk spoiiie
PJ18_RS04340	COG1196	nuclear chromosome segregation
PJ18_RS04345	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PJ18_RS04360	COG0488	(ABC) transporter
PJ18_RS04365	COG5002	protein histidine kinase activity
PJ18_RS04370	COG0745	RESPONSE REGULATOR receiver
PJ18_RS04375	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
PJ18_RS04385	COG0539	negative regulation of cytoplasmic translation
PJ18_RS04385	COG1185	polyribonucleotide nucleotidyltransferase activity
PJ18_RS04390	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
PJ18_RS04395	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
PJ18_RS04400	COG0072	phenylalanine-tRNA ligase activity
PJ18_RS04400	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
PJ18_RS04405	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
PJ18_RS04410	COG0537	adenosine 5'-monophosphoramidase activity
PJ18_RS04425	COG0765	amino acid transport
PJ18_RS04435	COG1115	amino acid carrier protein
PJ18_RS04440	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
PJ18_RS04445	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
PJ18_RS04470	COG1999	signal sequence binding
PJ18_RS04475	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
PJ18_RS04480	COG0776	regulation of translation
PJ18_RS04500	COG1966	Carbon starvation protein
PJ18_RS04505	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
PJ18_RS04510	COG0765	amino acid transport
PJ18_RS04515	COG0765	amino acid transport
PJ18_RS04520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PJ18_RS04525	COG1126	abc transporter atp-binding protein
PJ18_RS04530	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
PJ18_RS04535	COG2201	protein-glutamate methylesterase activity
PJ18_RS04550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
PJ18_RS04560	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
PJ18_RS04565	COG0012	GTP binding
PJ18_RS04570	COG0165	Argininosuccinate lyase
PJ18_RS04575	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
PJ18_RS04580	COG5016	pyruvate
PJ18_RS04580	COG0511	ligase activity, forming carbon-carbon bonds
PJ18_RS04585	COG0733	neurotransmitter:sodium symporter activity
PJ18_RS04590	COG0733	neurotransmitter:sodium symporter activity
PJ18_RS04595	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
PJ18_RS04655	COG0765	amino acid transport
PJ18_RS04665	COG0653	protein targeting
PJ18_RS04670	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
PJ18_RS04680	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
PJ18_RS04695	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
PJ18_RS04710	COG0840	transmembrane signaling receptor activity
PJ18_RS04720	COG0138	bifunctional purine biosynthesis protein purh
PJ18_RS04725	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
PJ18_RS04730	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
PJ18_RS04735	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
PJ18_RS04745	COG0706	membrane insertase activity
PJ18_RS04750	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
PJ18_RS04760	COG0230	Belongs to the bacterial ribosomal protein bL34 family
PJ18_RS04780	COG0824	Thioesterase
PJ18_RS04825	COG0500	methyltransferase
PJ18_RS04845	COG2195	Cleaves the N-terminal amino acid of tripeptides
PJ18_RS04850	COG0477	Major facilitator Superfamily
PJ18_RS04855	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
PJ18_RS04865	COG3022	response to hydroperoxide
PJ18_RS04870	COG1473	amidohydrolase
PJ18_RS04880	COG2807	transmembrane transport
PJ18_RS04900	COG0247	lactate metabolic process
PJ18_RS04900	COG2181	nitrate reductase activity
PJ18_RS04905	COG0635	Involved in the biosynthesis of porphyrin-containing compound
PJ18_RS04915	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
PJ18_RS04920	COG0113	porphobilinogen synthase activity
PJ18_RS04925	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
PJ18_RS04930	COG0357	Ribosomal RNA small subunit methyltransferase G
PJ18_RS04940	COG2855	membrane
PJ18_RS04945	COG0583	DNA-binding transcription factor activity
PJ18_RS04950	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
PJ18_RS04970	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PJ18_RS04975	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PJ18_RS04995	COG0343	queuine tRNA-ribosyltransferase activity
PJ18_RS05015	COG1333	cytochrome c biogenesis protein
PJ18_RS05015	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
PJ18_RS05065	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
PJ18_RS05070	COG2204	response regulator
PJ18_RS05085	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
PJ18_RS05100	COG0481	GTPase activity
PJ18_RS05125	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
PJ18_RS05135	COG0439	Biotin carboxylase
PJ18_RS05140	COG0772	Belongs to the SEDS family
PJ18_RS05165	COG0352	thiamine-phosphate diphosphorylase activity
PJ18_RS05170	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PJ18_RS05175	COG2022	thiamine diphosphate biosynthetic process
PJ18_RS05190	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
PJ18_RS05210	COG1193	negative regulation of DNA recombination
PJ18_RS05240	COG0516	GMP reductase activity
PJ18_RS05240	COG0517	IMP dehydrogenase activity
PJ18_RS05260	COG1058	Belongs to the CinA family
PJ18_RS05260	COG1546	Belongs to the CinA family
PJ18_RS05265	COG0456	acetyltransferase
PJ18_RS05270	COG0778	Nitroreductase
PJ18_RS05275	COG0778	Nitroreductase
PJ18_RS05285	COG0750	zinc metalloprotease
PJ18_RS05290	COG2990	Protein conserved in bacteria
PJ18_RS05295	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
PJ18_RS05305	COG0360	Binds together with S18 to 16S ribosomal RNA
PJ18_RS05310	COG0629	single-stranded DNA binding
PJ18_RS05315	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
PJ18_RS05320	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
PJ18_RS05330	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
PJ18_RS05335	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
PJ18_RS05360	COG0352	thiamine-phosphate diphosphorylase activity
PJ18_RS05380	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
PJ18_RS05390	COG0739	heme binding
PJ18_RS05395	COG0285	dihydrofolate synthase activity
PJ18_RS05415	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PJ18_RS05420	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
PJ18_RS05425	COG1862	Preprotein translocase
PJ18_RS05430	COG0815	Transfers the fatty acyl group on membrane lipoproteins
PJ18_RS05435	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
PJ18_RS05440	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
PJ18_RS05460	COG0210	DNA helicase
PJ18_RS05480	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
PJ18_RS05495	COG0542	response to heat
PJ18_RS05500	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
PJ18_RS05510	COG2095	MarC family integral membrane protein
PJ18_RS05515	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
PJ18_RS05520	COG2833	Protein of unknown function (DUF455)
PJ18_RS05525	COG1183	phosphatidylcholine synthase activity
PJ18_RS05535	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
PJ18_RS05540	COG2264	protein methyltransferase activity
PJ18_RS05545	COG0745	RESPONSE REGULATOR receiver
PJ18_RS05555	COG1086	Polysaccharide biosynthesis protein
PJ18_RS05560	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PJ18_RS05570	COG0110	maltose O-acetyltransferase activity
PJ18_RS05575	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
PJ18_RS05580	COG0438	transferase activity, transferring glycosyl groups
PJ18_RS05585	COG1287	oligosaccharyl transferase activity
PJ18_RS05590	COG0438	transferase activity, transferring glycosyl groups
PJ18_RS05595	COG1215	transferase activity, transferring glycosyl groups
PJ18_RS05600	COG0438	transferase activity, transferring glycosyl groups
PJ18_RS05605	COG1132	(ABC) transporter
PJ18_RS05610	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
PJ18_RS05620	COG0859	PFAM glycosyl transferase family 9
PJ18_RS05625	COG1560	Kdo2-lipid A biosynthetic process
PJ18_RS05630	COG0463	Glycosyl transferase, family 2
PJ18_RS05635	COG1442	glycosyl transferase family 8
PJ18_RS05635	COG1216	Glycosyl transferase, family 2
PJ18_RS05645	COG1442	glycosyl transferase family 8
PJ18_RS05645	COG1216	Glycosyl transferase, family 2
PJ18_RS05655	COG2089	acid synthase
PJ18_RS05670	COG0110	maltose O-acetyltransferase activity
PJ18_RS05675	COG1216	Glycosyl transferase, family 2
PJ18_RS05690	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
PJ18_RS05690	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
PJ18_RS05695	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PJ18_RS05700	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PJ18_RS05715	COG2217	Heavy metal translocating P-type atpase
PJ18_RS05720	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
PJ18_RS05725	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
PJ18_RS05730	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
PJ18_RS05735	COG2217	Heavy metal translocating P-type atpase
PJ18_RS05755	COG3610	response to peptide
PJ18_RS05765	COG0039	L-malate dehydrogenase activity
PJ18_RS05770	COG0586	Pfam SNARE associated Golgi protein
PJ18_RS05785	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
PJ18_RS05805	COG0018	arginyl-trna synthetase
PJ18_RS05810	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
PJ18_RS05815	COG0194	GDP metabolic process
PJ18_RS05825	COG1684	flagellar biosynthetic protein fliR
PJ18_RS05835	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
PJ18_RS05840	COG0052	Belongs to the universal ribosomal protein uS2 family
PJ18_RS05845	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
PJ18_RS05855	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
PJ18_RS05860	COG0723	plastoquinol--plastocyanin reductase activity
PJ18_RS05865	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
PJ18_RS05890	COG1301	dicarboxylic acid transport
PJ18_RS05905	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
PJ18_RS05915	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
PJ18_RS05920	COG1854	S-ribosylhomocysteine lyase activity
PJ18_RS05940	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
PJ18_RS05955	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
PJ18_RS05960	COG0552	protein localization to endoplasmic reticulum
PJ18_RS05975	COG1418	mRNA catabolic process
PJ18_RS05990	COG1295	ribonuclease BN
PJ18_RS05995	COG0277	FAD linked oxidase domain protein
PJ18_RS06005	COG0739	heme binding
PJ18_RS06015	COG1496	oxidoreductase activity
PJ18_RS06030	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
PJ18_RS06035	COG0459	protein refolding
PJ18_RS06040	COG0642	Histidine kinase
PJ18_RS06045	COG0745	RESPONSE REGULATOR receiver
PJ18_RS06065	COG0642	Histidine kinase
PJ18_RS06070	COG0745	RESPONSE REGULATOR receiver
PJ18_RS06075	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
PJ18_RS06080	COG0484	heat shock protein binding
PJ18_RS06085	COG0789	Transcriptional regulator
PJ18_RS06090	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
PJ18_RS06090	COG0475	glutathione-regulated potassium exporter activity
PJ18_RS06100	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
PJ18_RS06105	COG0751	glycine-tRNA ligase activity
PJ18_RS06110	COG0739	heme binding
PJ18_RS06120	COG0248	Ppx GppA phosphatase
PJ18_RS06125	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
PJ18_RS06130	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
PJ18_RS06140	COG2814	Major facilitator Superfamily
PJ18_RS06150	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
PJ18_RS06155	COG0731	radical SAM domain protein
PJ18_RS06165	COG0322	excinuclease ABC activity
PJ18_RS06175	COG0518	GMP synthase (glutamine-hydrolyzing) activity
PJ18_RS06175	COG0519	Catalyzes the synthesis of GMP from XMP
PJ18_RS06200	COG1185	polyribonucleotide nucleotidyltransferase activity
PJ18_RS06210	COG1942	4-Oxalocrotonate Tautomerase
PJ18_RS06225	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
PJ18_RS06230	COG4773	Receptor
PJ18_RS06235	COG0484	heat shock protein binding
PJ18_RS06240	COG0745	RESPONSE REGULATOR receiver
PJ18_RS06245	COG0642	Histidine kinase
PJ18_RS06250	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
PJ18_RS06255	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
PJ18_RS06260	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
PJ18_RS06265	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
PJ18_RS06270	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
PJ18_RS06275	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
PJ18_RS06275	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
PJ18_RS06290	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
PJ18_RS06295	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
PJ18_RS06300	COG1758	RNA polymerase activity
PJ18_RS06305	COG0528	UMP kinase activity
PJ18_RS06320	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
PJ18_RS06325	COG0220	tRNA (guanine-N7-)-methyltransferase activity
PJ18_RS06335	COG0564	pseudouridine synthase activity
PJ18_RS06340	COG0772	Belongs to the SEDS family
PJ18_RS06350	COG0582	viral genome integration into host DNA
PJ18_RS06365	COG0863	Belongs to the N(4) N(6)-methyltransferase family
PJ18_RS06615	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
PJ18_RS06620	COG0569	domain protein
PJ18_RS06625	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
PJ18_RS06630	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
PJ18_RS06635	COG0281	malic enzyme
PJ18_RS06635	COG0280	phosphate acetyltransferase
PJ18_RS06640	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
PJ18_RS06650	COG0439	Biotin carboxylase
PJ18_RS06655	COG0511	ligase activity, forming carbon-carbon bonds
PJ18_RS06660	COG0717	Belongs to the dCTP deaminase family
PJ18_RS06665	COG1086	Polysaccharide biosynthesis protein
PJ18_RS06670	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PJ18_RS06675	COG4310	Domain of unknown function (DUF2172)
PJ18_RS06710	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
PJ18_RS06750	COG1083	cytidylyl-transferase
PJ18_RS06755	COG3980	spore coat polysaccharide biosynthesis protein
PJ18_RS06760	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
PJ18_RS06765	COG0107	imidazoleglycerol-phosphate synthase activity
PJ18_RS06770	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
PJ18_RS06780	COG2089	acid synthase
PJ18_RS06790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PJ18_RS06795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
PJ18_RS06820	COG2089	acid synthase
PJ18_RS06825	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
PJ18_RS06830	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
PJ18_RS06840	COG1083	cytidylyl-transferase
PJ18_RS06845	COG1028	Short-chain dehydrogenase reductase Sdr
PJ18_RS06870	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PJ18_RS06875	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
PJ18_RS06895	COG2165	general secretion pathway protein
PJ18_RS06900	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
PJ18_RS06910	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
PJ18_RS06915	COG0575	Belongs to the CDS family
PJ18_RS06925	COG1293	RNA-binding protein homologous to eukaryotic snRNP
PJ18_RS06930	COG0746	molybdenum cofactor guanylyltransferase activity
PJ18_RS06935	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
PJ18_RS06940	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PJ18_RS06945	COG4605	iron ion homeostasis
PJ18_RS06950	COG4604	ABC transporter, ATP-binding protein
PJ18_RS06955	COG4607	ABC-type enterochelin transport system periplasmic component
PJ18_RS06970	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
PJ18_RS06975	COG3005	denitrification pathway
PJ18_RS06980	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
PJ18_RS06990	COG2255	four-way junction helicase activity
PJ18_RS06995	COG0628	permease
PJ18_RS07000	COG0114	fumarate hydratase activity
PJ18_RS07010	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
PJ18_RS07020	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
PJ18_RS07025	COG2252	PERMEase
PJ18_RS07035	COG2853	Lipoprotein
PJ18_RS07050	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
PJ18_RS07055	COG2814	Major facilitator Superfamily
PJ18_RS07070	COG3276	selenocysteine insertion sequence binding
PJ18_RS07085	COG0716	FMN binding
PJ18_RS07100	COG0753	catalase activity
PJ18_RS07110	COG2964	Protein conserved in bacteria
PJ18_RS07115	COG0251	oxidation-reduction process
PJ18_RS07120	COG3069	C4-dicarboxylate transmembrane transporter activity
PJ18_RS07140	COG1918	ferrous iron import across plasma membrane
PJ18_RS07145	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
PJ18_RS07155	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
PJ18_RS07160	COG0149	triose-phosphate isomerase activity
PJ18_RS07165	COG0126	phosphoglycerate kinase activity
PJ18_RS07170	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
PJ18_RS07195	COG1580	Controls the rotational direction of flagella during chemotaxis
PJ18_RS07200	COG0736	holo-[acyl-carrier-protein] synthase activity
PJ18_RS07210	COG2124	cytochrome p450
PJ18_RS07230	COG0529	Catalyzes the synthesis of activated sulfate
PJ18_RS07235	COG1213	nucleotidyl transferase
PJ18_RS07240	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
PJ18_RS07245	COG3848	Pyruvate phosphate dikinase
PJ18_RS07245	COG0574	Belongs to the PEP-utilizing enzyme family
PJ18_RS07250	COG2226	methyltransferase
PJ18_RS07280	COG0572	uridine kinase
PJ18_RS07295	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
PJ18_RS07315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
PJ18_RS07325	COG1216	Glycosyl transferase, family 2
PJ18_RS07325	COG1442	glycosyl transferase family 8
PJ18_RS07335	COG1215	transferase activity, transferring glycosyl groups
PJ18_RS07335	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
PJ18_RS07345	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
PJ18_RS07345	COG0517	IMP dehydrogenase activity
PJ18_RS07390	COG0037	tRNA processing
PJ18_RS07395	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
PJ18_RS07400	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
PJ18_RS07415	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
PJ18_RS07440	COG3951	Flagellar rod assembly protein muramidase FlgJ
PJ18_RS07465	COG0730	response to heat
PJ18_RS07470	COG1459	type II secretion system
PJ18_RS07475	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
PJ18_RS07505	COG0546	phosphoglycolate phosphatase activity
PJ18_RS07515	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
PJ18_RS07520	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
PJ18_RS07525	COG0210	DNA helicase
PJ18_RS07530	COG2887	Belongs to the helicase family. UvrD subfamily
PJ18_RS07575	COG0745	RESPONSE REGULATOR receiver
PJ18_RS07590	COG0505	Belongs to the CarA family
PJ18_RS07610	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
PJ18_RS07625	COG0425	Belongs to the sulfur carrier protein TusA family
PJ18_RS07630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
PJ18_RS07640	COG0709	Synthesizes selenophosphate from selenide and ATP
PJ18_RS07660	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
PJ18_RS07670	COG0437	4 iron, 4 sulfur cluster binding
PJ18_RS07680	COG3383	formate dehydrogenase (NAD+) activity
PJ18_RS07710	COG0314	molybdopterin synthase activity
PJ18_RS07715	COG0303	'Molybdopterin
PJ18_RS07720	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
PJ18_RS07730	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
PJ18_RS07745	COG3069	C4-dicarboxylate transmembrane transporter activity
PJ18_RS07750	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
PJ18_RS07755	COG0237	dephospho-CoA kinase activity
PJ18_RS07765	COG2992	FlgJ-related protein
PJ18_RS07775	COG0783	Belongs to the Dps family
PJ18_RS07780	COG0166	Belongs to the GPI family
PJ18_RS07790	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
PJ18_RS07795	COG3839	Belongs to the ABC transporter superfamily
PJ18_RS07800	COG4662	Binding-protein-dependent transport system inner membrane component
PJ18_RS07805	COG2998	abc-type tungstate transport system, permease component
PJ18_RS07810	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
PJ18_RS07815	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
PJ18_RS07820	COG1984	allophanate hydrolase subunit 2
PJ18_RS07830	COG2249	NAD(P)H dehydrogenase (quinone) activity
PJ18_RS07835	COG1733	regulation of RNA biosynthetic process
PJ18_RS07845	COG1064	alcohol dehydrogenase
PJ18_RS07850	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
PJ18_RS07870	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
PJ18_RS07875	COG2910	NAD(P)H-binding
PJ18_RS07880	COG1733	regulation of RNA biosynthetic process
PJ18_RS07895	COG0640	Transcriptional regulator
PJ18_RS07920	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PJ18_RS07925	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
PJ18_RS07935	COG0839	Belongs to the complex I subunit 6 family
PJ18_RS07970	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PJ18_RS07975	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PJ18_RS07980	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
PJ18_RS07995	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
PJ18_RS08000	COG0601	transmembrane transport
PJ18_RS08010	COG0277	FAD linked oxidase domain protein
PJ18_RS08020	COG4615	Cyclic peptide transporter
PJ18_RS08040	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
PJ18_RS08045	COG0257	Belongs to the bacterial ribosomal protein bL36 family
PJ18_RS08055	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
PJ18_RS08060	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
PJ18_RS08065	COG0202	RNA polymerase activity
PJ18_RS08070	COG0203	ribosomal protein L17
PJ18_RS08080	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
PJ18_RS08085	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
PJ18_RS08085	COG0131	Imidazoleglycerol-phosphate dehydratase
PJ18_RS08095	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
PJ18_RS08110	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
PJ18_RS08110	COG0140	phosphoribosyl-ATP diphosphatase activity
PJ18_RS08115	COG2171	N-acyltransferase activity
PJ18_RS08120	COG0489	protein tyrosine kinase activity
PJ18_RS08125	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
PJ18_RS08125	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
PJ18_RS08130	COG0745	RESPONSE REGULATOR receiver
PJ18_RS08135	COG2046	Belongs to the sulfate adenylyltransferase family
PJ18_RS08140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
PJ18_RS08145	COG0268	Binds directly to 16S ribosomal RNA
PJ18_RS08150	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
PJ18_RS08155	COG0748	coenzyme F420 binding
PJ18_RS08160	COG4771	TonB-dependent receptor
PJ18_RS08165	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
PJ18_RS08170	COG1120	ATPase activity
PJ18_RS08175	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
PJ18_RS08190	COG1194	a g-specific adenine glycosylase
PJ18_RS08220	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PJ18_RS08220	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
PJ18_RS08230	COG1760	l-serine dehydratase
PJ18_RS08235	COG0814	amino acid
PJ18_RS08250	COG0811	peptide transport
PJ18_RS08255	COG0848	biopolymer transport protein
PJ18_RS08280	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
PJ18_RS08290	COG0328	RNA-DNA hybrid ribonuclease activity
PJ18_RS08300	COG0358	DNA primase activity
PJ18_RS08315	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
PJ18_RS08320	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
PJ18_RS08335	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
PJ18_RS08340	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
PJ18_RS08345	COG1127	ABC transporter
PJ18_RS08355	COG3218	ABC-type transport auxiliary lipoprotein component
PJ18_RS08355	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
PJ18_RS08365	COG0024	Methionine aminopeptidase
PJ18_RS08370	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
PJ18_RS08375	COG0791	NLP P60 protein
PJ18_RS08385	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
PJ18_RS08395	COG0672	)-iron permease
PJ18_RS08420	COG1136	(ABC) transporter
PJ18_RS08475	COG1793	dna ligase
PJ18_RS08490	COG0148	phosphopyruvate hydratase activity
PJ18_RS08495	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
PJ18_RS08500	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
PJ18_RS08505	COG1987	bacterial-type flagellum assembly
PJ18_RS08510	COG0812	UDP-N-acetylmuramate dehydrogenase activity
PJ18_RS08535	COG1218	3'(2'),5'-bisphosphate nucleotidase
PJ18_RS08540	COG0372	Belongs to the citrate synthase family
PJ18_RS08550	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
PJ18_RS08555	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
PJ18_RS08565	COG0201	protein transport
PJ18_RS08570	COG0200	Binds to the 23S rRNA
PJ18_RS08575	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
PJ18_RS08580	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
PJ18_RS08585	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
PJ18_RS08590	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
PJ18_RS08595	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
PJ18_RS08600	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
PJ18_RS08605	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
PJ18_RS08610	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
PJ18_RS08615	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
PJ18_RS08620	COG0255	Belongs to the universal ribosomal protein uL29 family
PJ18_RS08625	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
PJ18_RS08630	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
PJ18_RS08640	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
PJ18_RS08650	COG0089	rRNA binding
PJ18_RS08655	COG0088	Forms part of the polypeptide exit tunnel
PJ18_RS08660	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
PJ18_RS08665	COG0051	transcription antitermination factor activity, RNA binding
PJ18_RS08670	COG1187	pseudouridine synthase activity
PJ18_RS08675	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
PJ18_RS08690	COG0820	rRNA (adenine-C2-)-methyltransferase activity
PJ18_RS08735	COG0473	3-isopropylmalate dehydrogenase activity
PJ18_RS08740	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
PJ18_RS08755	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
PJ18_RS08765	COG1749	Flagellar hook protein flgE
PJ18_RS08770	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group