locus-tag	class	description
UC78_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
UC78_RS00010	COG0592	DNA-directed DNA polymerase activity
UC78_RS00015	COG0187	DNA topoisomerase II activity
UC78_RS00030	COG2056	Na+-H+ antiporter family
UC78_RS00035	COG0070	glutamate synthase
UC78_RS00035	COG0069	glutamate synthase activity
UC78_RS00035	COG0067	glutamate synthase
UC78_RS00040	COG0493	'glutamate synthase
UC78_RS00045	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
UC78_RS00055	COG1592	Rubrerythrin
UC78_RS00065	COG3477	response to acidic pH
UC78_RS00075	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
UC78_RS00090	COG0840	transmembrane signaling receptor activity
UC78_RS00095	COG1858	cytochrome C peroxidase
UC78_RS00100	COG0179	Fumarylacetoacetate (FAA) hydrolase
UC78_RS00105	COG0564	pseudouridine synthase activity
UC78_RS00110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
UC78_RS00115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UC78_RS00120	COG1823	symporter activity
UC78_RS00140	COG0252	asparaginase activity
UC78_RS00170	COG0484	heat shock protein binding
UC78_RS00190	COG0405	Gamma-glutamyltransferase
UC78_RS00215	COG2814	Major facilitator Superfamily
UC78_RS00235	COG1217	gtp-binding protein TYPA
UC78_RS00250	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
UC78_RS00270	COG0471	metal ion transport
UC78_RS00275	COG0482	sulfurtransferase activity
UC78_RS00280	COG1611	Belongs to the LOG family
UC78_RS00305	COG1776	CheC inhibitor of MCP methylation
UC78_RS00305	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UC78_RS00310	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UC78_RS00315	COG1191	sigma factor activity
UC78_RS00325	COG0455	bacterial-type flagellum organization
UC78_RS00330	COG1419	protein localization to endoplasmic reticulum
UC78_RS00335	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
UC78_RS00340	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
UC78_RS00345	COG0402	S-adenosylhomocysteine deaminase activity
UC78_RS00350	COG0616	signal peptide processing
UC78_RS00365	COG2703	oxygen carrier activity
UC78_RS00380	COG1139	Iron-sulfur cluster binding protein
UC78_RS00385	COG0247	lactate metabolic process
UC78_RS00400	COG3021	interspecies interaction between organisms
UC78_RS00415	COG1271	oxidase subunit
UC78_RS00420	COG1294	oxidase, subunit
UC78_RS00430	COG1794	racemase activity, acting on amino acids and derivatives
UC78_RS00435	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
UC78_RS00440	COG1027	Aspartate ammonia-lyase
UC78_RS00445	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
UC78_RS00480	COG0261	This protein binds to 23S rRNA in the presence of protein L20
UC78_RS00485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
UC78_RS00500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
UC78_RS00505	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
UC78_RS00505	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
UC78_RS00510	COG1192	Involved in chromosome partitioning
UC78_RS00515	COG1475	DNA binding
UC78_RS00525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
UC78_RS00530	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
UC78_RS00545	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
UC78_RS00550	COG0355	proton-transporting ATP synthase activity, rotational mechanism
UC78_RS00555	COG0811	peptide transport
UC78_RS00560	COG0848	biopolymer transport protein
UC78_RS00575	COG2885	chlorophyll binding
UC78_RS00585	COG1047	Peptidyl-prolyl cis-trans
UC78_RS00590	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
UC78_RS00595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
UC78_RS00600	COG0037	tRNA processing
UC78_RS00625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
UC78_RS00635	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
UC78_RS00645	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
UC78_RS00655	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
UC78_RS00680	COG0083	homoserine kinase activity
UC78_RS00700	COG0779	Required for maturation of 30S ribosomal subunits
UC78_RS00705	COG1401	restriction endodeoxyribonuclease activity
UC78_RS00715	COG1108	ABC-type Mn2 Zn2 transport systems permease components
UC78_RS00720	COG1121	(ABC) transporter
UC78_RS00740	COG0492	ferredoxin-NADP+ reductase activity
UC78_RS00745	COG3118	belongs to the thioredoxin family
UC78_RS00750	COG0792	nuclease activity
UC78_RS00755	COG0460	homoserine dehydrogenase
UC78_RS00760	COG0436	Aminotransferase
UC78_RS00775	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
UC78_RS00780	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
UC78_RS00785	COG0254	rRNA binding
UC78_RS00790	COG1385	rRNA (uridine-N3-)-methyltransferase activity
UC78_RS00810	COG0602	queuosine metabolic process
UC78_RS00815	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
UC78_RS00840	COG1971	Probably functions as a manganese efflux pump
UC78_RS00855	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
UC78_RS00865	COG3842	ATPase activity
UC78_RS00875	COG1840	ABC-type Fe3 transport system, periplasmic component
UC78_RS00885	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
UC78_RS00890	COG1253	flavin adenine dinucleotide binding
UC78_RS00900	COG2824	Alkylphosphonate utilization operon protein PhnA
UC78_RS00905	COG0861	Integral membrane protein TerC family
UC78_RS00910	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
UC78_RS00915	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
UC78_RS00915	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
UC78_RS00925	COG0606	chelatase, subunit chli
UC78_RS00930	COG0242	peptide deformylase activity
UC78_RS00940	COG0544	peptidyl-prolyl cis-trans isomerase activity
UC78_RS00945	COG0302	gtp cyclohydrolase
UC78_RS00950	COG1157	protein secretion by the type III secretion system
UC78_RS00955	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
UC78_RS00965	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
UC78_RS00965	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
UC78_RS00990	COG2851	Citrate transporter
UC78_RS00995	COG1297	OPT oligopeptide transporter protein
UC78_RS01010	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
UC78_RS01070	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
UC78_RS01075	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
UC78_RS01080	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
UC78_RS01085	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
UC78_RS01095	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
UC78_RS01115	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
UC78_RS01120	COG0670	Belongs to the BI1 family
UC78_RS01125	COG0288	reversible hydration of carbon dioxide
UC78_RS01130	COG0668	transmembrane transport
UC78_RS01155	COG0291	Belongs to the bacterial ribosomal protein bL35 family
UC78_RS01160	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
UC78_RS01165	COG0840	transmembrane signaling receptor activity
UC78_RS01180	COG0477	Major facilitator Superfamily
UC78_RS01195	COG2921	Belongs to the UPF0250 family
UC78_RS01205	COG0708	Exodeoxyribonuclease III
UC78_RS01210	COG2194	sulfuric ester hydrolase activity
UC78_RS01215	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
UC78_RS01225	COG0418	dihydroorotase activity
UC78_RS01235	COG2226	methyltransferase
UC78_RS01240	COG0840	transmembrane signaling receptor activity
UC78_RS01245	COG0428	transporter
UC78_RS01250	COG0243	molybdopterin cofactor binding
UC78_RS01270	COG0330	HflC and HflK could
UC78_RS01280	COG1942	4-Oxalocrotonate Tautomerase
UC78_RS01285	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
UC78_RS01290	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
UC78_RS01305	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
UC78_RS01310	COG1077	Cell shape determining protein MreB Mrl
UC78_RS01320	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
UC78_RS01340	COG0835	chemotaxis
UC78_RS01345	COG0643	Histidine kinase
UC78_RS01345	COG0784	Response regulator, receiver
UC78_RS01345	COG2198	Histidine kinase
UC78_RS01350	COG0835	chemotaxis
UC78_RS01350	COG0784	Response regulator, receiver
UC78_RS01360	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
UC78_RS01365	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
UC78_RS01410	COG0454	-acetyltransferase
UC78_RS01440	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
UC78_RS01460	COG4106	trans-aconitate 2-methyltransferase activity
UC78_RS01465	COG2830	Protein of unknown function (DUF452)
UC78_RS01475	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
UC78_RS01480	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
UC78_RS01485	COG2076	Multidrug Resistance protein
UC78_RS01500	COG0193	aminoacyl-tRNA hydrolase activity
UC78_RS01510	COG0019	diaminopimelate decarboxylase activity
UC78_RS01525	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
UC78_RS01535	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UC78_RS01545	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
UC78_RS01565	COG1570	exodeoxyribonuclease VII activity
UC78_RS01570	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
UC78_RS01575	COG0251	oxidation-reduction process
UC78_RS01580	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UC78_RS01585	COG0416	fatty acid biosynthetic process
UC78_RS01590	COG0333	Belongs to the bacterial ribosomal protein bL32 family
UC78_RS01610	COG0450	alkyl hydroperoxide reductase
UC78_RS01615	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UC78_RS01620	COG1360	Flagellar Motor Protein
UC78_RS01625	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
UC78_RS01635	COG0477	Major facilitator Superfamily
UC78_RS01645	COG1238	metal cluster binding
UC78_RS01650	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
UC78_RS01655	COG0730	response to heat
UC78_RS01670	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
UC78_RS01670	COG0512	Glutamine amidotransferase of anthranilate synthase
UC78_RS01680	COG0133	tryptophan synthase activity
UC78_RS01695	COG1776	CheC inhibitor of MCP methylation
UC78_RS01695	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
UC78_RS01710	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
UC78_RS01715	COG0745	RESPONSE REGULATOR receiver
UC78_RS01735	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
UC78_RS01745	COG1981	membrane
UC78_RS01750	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UC78_RS01760	COG1538	Outer membrane efflux protein
UC78_RS01770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UC78_RS01785	COG0828	Belongs to the bacterial ribosomal protein bS21 family
UC78_RS01795	COG0754	glutathionylspermidine amidase activity
UC78_RS01800	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
UC78_RS01820	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UC78_RS01830	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
UC78_RS01835	COG0284	orotidine-5'-phosphate decarboxylase activity
UC78_RS01840	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
UC78_RS01845	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
UC78_RS01860	COG1160	GTP binding
UC78_RS01865	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
UC78_RS01895	COG0579	oxidoreductase
UC78_RS01900	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
UC78_RS01920	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UC78_RS01940	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
UC78_RS01955	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
UC78_RS01965	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
UC78_RS01975	COG1053	succinate dehydrogenase
UC78_RS01980	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
UC78_RS02045	COG0488	(ABC) transporter
UC78_RS02060	COG1739	Uncharacterized protein family UPF0029
UC78_RS02100	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
UC78_RS02110	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
UC78_RS02120	COG1028	Short-chain dehydrogenase reductase Sdr
UC78_RS02130	COG1053	succinate dehydrogenase
UC78_RS02135	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
UC78_RS02140	COG2048	Heterodisulfide reductase, subunit B
UC78_RS02145	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
UC78_RS02150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
UC78_RS02155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
UC78_RS02165	COG4771	TonB-dependent receptor
UC78_RS02170	COG0494	nUDIX hydrolase
UC78_RS02175	COG0840	transmembrane signaling receptor activity
UC78_RS02185	COG0227	Belongs to the bacterial ribosomal protein bL28 family
UC78_RS02190	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
UC78_RS02200	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
UC78_RS02220	COG2121	Domain of unknown function (DUF374)
UC78_RS02235	COG0195	Participates in both transcription termination and antitermination
UC78_RS02245	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
UC78_RS02250	COG0612	Peptidase, M16
UC78_RS02255	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
UC78_RS02260	COG2346	COG2346, Truncated hemoglobins
UC78_RS02275	COG0765	amino acid transport
UC78_RS02305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
UC78_RS02310	COG0267	Belongs to the bacterial ribosomal protein bL33 family
UC78_RS02325	COG0250	Participates in transcription elongation, termination and antitermination
UC78_RS02330	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
UC78_RS02335	COG0081	regulation of translation
UC78_RS02340	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
UC78_RS02345	COG0222	ribosome binding
UC78_RS02365	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
UC78_RS02375	COG2721	sulfolactate sulfo-lyase activity
UC78_RS02380	COG2271	Major facilitator Superfamily
UC78_RS02390	COG0738	Major facilitator superfamily
UC78_RS02405	COG1012	belongs to the aldehyde dehydrogenase family
UC78_RS02410	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
UC78_RS02415	COG0049	tRNA binding
UC78_RS02450	COG0134	indole-3-glycerol-phosphate synthase activity
UC78_RS02460	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
UC78_RS02465	COG0004	ammonium transporteR
UC78_RS02470	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
UC78_RS02475	COG0673	inositol 2-dehydrogenase activity
UC78_RS02490	COG0424	maF-like protein
UC78_RS02500	COG0542	response to heat
UC78_RS02505	COG1937	Protein conserved in bacteria
UC78_RS02510	COG0793	Belongs to the peptidase S41A family
UC78_RS02515	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
UC78_RS02520	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
UC78_RS02525	COG0047	phosphoribosylformylglycinamidine synthase activity
UC78_RS02535	COG0204	Acyl-transferase
UC78_RS02545	COG0326	Molecular chaperone. Has ATPase activity
UC78_RS02550	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
UC78_RS02570	COG1677	Flagellar hook-basal body complex protein FliE
UC78_RS02575	COG1558	bacterial-type flagellum-dependent cell motility
UC78_RS02580	COG1815	bacterial-type flagellum-dependent cell motility
UC78_RS02600	COG0039	L-malate dehydrogenase activity
UC78_RS02610	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
UC78_RS02620	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
UC78_RS02620	COG0674	pyruvate-flavodoxin oxidoreductase activity
UC78_RS02625	COG1013	pyruvate-flavodoxin oxidoreductase activity
UC78_RS02645	COG0142	geranyltranstransferase activity
UC78_RS02665	COG0181	hydroxymethylbilane synthase activity
UC78_RS02670	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
UC78_RS02680	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
UC78_RS02695	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
UC78_RS02725	COG1289	transmembrane transporter activity
UC78_RS02730	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
UC78_RS02735	COG0492	ferredoxin-NADP+ reductase activity
UC78_RS02750	COG0305	Participates in initiation and elongation during chromosome replication
UC78_RS02795	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UC78_RS02795	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UC78_RS02800	COG1610	YqeY-like protein
UC78_RS02805	COG0028	Belongs to the TPP enzyme family
UC78_RS02810	COG0440	acetolactate synthase activity
UC78_RS02820	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
UC78_RS02825	COG0805	protein transport
UC78_RS02835	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UC78_RS02840	COG0494	nUDIX hydrolase
UC78_RS02845	COG0527	aspartate kinase activity
UC78_RS02860	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
UC78_RS02865	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
UC78_RS02880	COG0196	riboflavin kinase activity
UC78_RS02885	COG2890	protein-(glutamine-N5) methyltransferase activity
UC78_RS02900	COG2860	membrane
UC78_RS02910	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
UC78_RS02915	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UC78_RS02920	COG0191	fructose-bisphosphate aldolase activity
UC78_RS02940	COG0733	neurotransmitter:sodium symporter activity
UC78_RS02945	COG2258	MOSC domain
UC78_RS02960	COG1473	amidohydrolase
UC78_RS02965	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
UC78_RS02970	COG1136	(ABC) transporter
UC78_RS02970	COG0577	efflux transmembrane transporter activity
UC78_RS02975	COG1538	Outer membrane efflux protein
UC78_RS02990	COG1696	Membrane protein involved in D-alanine export
UC78_RS02995	COG1528	Iron-storage protein
UC78_RS03000	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
UC78_RS03005	COG0573	inorganic phosphate transmembrane transporter activity
UC78_RS03010	COG0581	inorganic phosphate transmembrane transporter activity
UC78_RS03020	COG0534	Mate efflux family protein
UC78_RS03035	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
UC78_RS03045	COG0298	carbon dioxide binding
UC78_RS03050	COG0409	Hydrogenase expression formation protein
UC78_RS03055	COG0309	Hydrogenase expression formation protein (HypE)
UC78_RS03060	COG0375	protein maturation
UC78_RS03075	COG0557	exoribonuclease II activity
UC78_RS03080	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
UC78_RS03090	COG0758	DNA mediated transformation
UC78_RS03105	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UC78_RS03110	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
UC78_RS03115	COG0563	adenylate kinase activity
UC78_RS03130	COG0497	DNA recombination
UC78_RS03140	COG0084	hydrolase, TatD family'
UC78_RS03145	COG1388	LysM domain
UC78_RS03145	COG0791	NLP P60 protein
UC78_RS03150	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
UC78_RS03170	COG0218	Necessary for normal cell division and for the maintenance of normal septation
UC78_RS03210	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
UC78_RS03215	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
UC78_RS03235	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
UC78_RS03240	COG0802	atpase or kinase
UC78_RS03245	COG1137	ATPase activity
UC78_RS03250	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
UC78_RS03265	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
UC78_RS03270	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
UC78_RS03275	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
UC78_RS03280	COG2205	protein histidine kinase activity
UC78_RS03285	COG0556	nucleotide-excision repair
UC78_RS03305	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
UC78_RS03315	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
UC78_RS03325	COG0280	phosphate acetyltransferase
UC78_RS03350	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UC78_RS03355	COG0849	cell division
UC78_RS03360	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
UC78_RS03365	COG4786	Flagellar basal body rod
UC78_RS03370	COG4786	Flagellar basal body rod
UC78_RS03375	COG0174	glutamine synthetase
UC78_RS03385	COG0826	peptidase U32
UC78_RS03390	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
UC78_RS03400	COG0752	glycyl-tRNA synthetase alpha subunit
UC78_RS03405	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
UC78_RS03415	COG1519	Transferase
UC78_RS03415	COG0220	tRNA (guanine-N7-)-methyltransferase activity
UC78_RS03420	COG0564	pseudouridine synthase activity
UC78_RS03425	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
UC78_RS03430	COG0228	four-way junction DNA binding
UC78_RS03435	COG1837	Belongs to the UPF0109 family
UC78_RS03440	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
UC78_RS03445	COG0336	Belongs to the RNA methyltransferase TrmD family
UC78_RS03450	COG0335	large ribosomal subunit rRNA binding
UC78_RS03460	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
UC78_RS03465	COG1393	Belongs to the ArsC family
UC78_RS03470	COG0587	DNA-directed DNA polymerase activity
UC78_RS03475	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
UC78_RS03490	COG2890	protein-(glutamine-N5) methyltransferase activity
UC78_RS03495	COG0501	Belongs to the peptidase M48B family
UC78_RS03505	COG0521	Mo-molybdopterin cofactor biosynthetic process
UC78_RS03510	COG0598	Magnesium transport protein CorA
UC78_RS03530	COG1178	ABC-type Fe3 transport system permease component
UC78_RS03540	COG3842	ATPase activity
UC78_RS03610	COG1420	regulation of RNA biosynthetic process
UC78_RS03635	COG0436	Aminotransferase
UC78_RS03640	COG1045	serine acetyltransferase
UC78_RS03645	COG1166	arginine decarboxylase activity
UC78_RS03660	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
UC78_RS03665	COG0163	prenyltransferase activity
UC78_RS03675	COG1464	Belongs to the NlpA lipoprotein family
UC78_RS03680	COG1464	Belongs to the NlpA lipoprotein family
UC78_RS03685	COG1464	Belongs to the NlpA lipoprotein family
UC78_RS03690	COG2011	ABC-type metal ion transport system permease component
UC78_RS03695	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UC78_RS03710	COG0210	DNA helicase
UC78_RS03720	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
UC78_RS03730	COG0437	4 iron, 4 sulfur cluster binding
UC78_RS03735	COG0348	domain, Protein
UC78_RS03740	COG3043	anaerobic respiration
UC78_RS03775	COG0788	formyltetrahydrofolate deformylase activity
UC78_RS03780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
UC78_RS03790	COG0642	Histidine kinase
UC78_RS03800	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
UC78_RS03815	COG1181	Belongs to the D-alanine--D-alanine ligase family
UC78_RS03820	COG0632	four-way junction helicase activity
UC78_RS03830	COG0728	peptidoglycan biosynthetic process
UC78_RS03840	COG1132	(ABC) transporter
UC78_RS03845	COG0167	dihydroorotate dehydrogenase activity
UC78_RS03850	COG0612	Peptidase, M16
UC78_RS03860	COG1028	Short-chain dehydrogenase reductase Sdr
UC78_RS03875	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
UC78_RS03885	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
UC78_RS03890	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
UC78_RS03905	COG1338	Plays a role in the flagellum-specific transport system
UC78_RS03945	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
UC78_RS03970	COG4221	oxidoreductase activity
UC78_RS03980	COG1049	propionate catabolic process, 2-methylcitrate cycle
UC78_RS03985	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
UC78_RS03995	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UC78_RS03995	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UC78_RS04005	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
UC78_RS04030	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UC78_RS04035	COG1408	metallophosphoesterase
UC78_RS04040	COG0688	phosphatidylethanolamine metabolic process
UC78_RS04080	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
UC78_RS04085	COG0681	Belongs to the peptidase S26 family
UC78_RS04090	COG0303	'Molybdopterin
UC78_RS04110	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
UC78_RS04110	COG0512	Glutamine amidotransferase of anthranilate synthase
UC78_RS04115	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
UC78_RS04120	COG0582	viral genome integration into host DNA
UC78_RS04125	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
UC78_RS04130	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
UC78_RS04145	COG3258	Cytochrome c
UC78_RS04175	COG2404	hydrolase activity, acting on ester bonds
UC78_RS04180	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
UC78_RS04185	COG1959	2 iron, 2 sulfur cluster binding
UC78_RS04190	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
UC78_RS04195	COG1674	ftsk spoiiie
UC78_RS04195	COG1196	nuclear chromosome segregation
UC78_RS04200	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UC78_RS04215	COG0488	(ABC) transporter
UC78_RS04220	COG3850	Histidine kinase
UC78_RS04220	COG5002	protein histidine kinase activity
UC78_RS04225	COG0745	RESPONSE REGULATOR receiver
UC78_RS04230	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
UC78_RS04240	COG0539	negative regulation of cytoplasmic translation
UC78_RS04240	COG1185	polyribonucleotide nucleotidyltransferase activity
UC78_RS04255	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
UC78_RS04255	COG0072	phenylalanine-tRNA ligase activity
UC78_RS04260	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
UC78_RS04265	COG0537	adenosine 5'-monophosphoramidase activity
UC78_RS04280	COG0765	amino acid transport
UC78_RS04290	COG1115	amino acid carrier protein
UC78_RS04295	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
UC78_RS04300	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
UC78_RS04325	COG1999	signal sequence binding
UC78_RS04330	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
UC78_RS04335	COG0776	regulation of translation
UC78_RS04355	COG1966	Carbon starvation protein
UC78_RS04360	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
UC78_RS04365	COG0765	amino acid transport
UC78_RS04370	COG0765	amino acid transport
UC78_RS04375	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UC78_RS04380	COG1126	abc transporter atp-binding protein
UC78_RS04385	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
UC78_RS04390	COG2201	protein-glutamate methylesterase activity
UC78_RS04415	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
UC78_RS04420	COG0012	GTP binding
UC78_RS04430	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
UC78_RS04435	COG5016	pyruvate
UC78_RS04435	COG0511	ligase activity, forming carbon-carbon bonds
UC78_RS04440	COG0733	neurotransmitter:sodium symporter activity
UC78_RS04445	COG0733	neurotransmitter:sodium symporter activity
UC78_RS04510	COG0765	amino acid transport
UC78_RS04525	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
UC78_RS04535	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
UC78_RS04550	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
UC78_RS04565	COG0840	transmembrane signaling receptor activity
UC78_RS04570	COG0138	bifunctional purine biosynthesis protein purh
UC78_RS04575	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
UC78_RS04595	COG0706	membrane insertase activity
UC78_RS04600	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
UC78_RS04610	COG0230	Belongs to the bacterial ribosomal protein bL34 family
UC78_RS04630	COG0824	Thioesterase
UC78_RS04665	COG2703	oxygen carrier activity
UC78_RS04690	COG2195	Cleaves the N-terminal amino acid of tripeptides
UC78_RS04695	COG0477	Major facilitator Superfamily
UC78_RS04700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
UC78_RS04710	COG3022	response to hydroperoxide
UC78_RS04715	COG1473	amidohydrolase
UC78_RS04720	COG2807	transmembrane transport
UC78_RS04740	COG2181	nitrate reductase activity
UC78_RS04740	COG0247	lactate metabolic process
UC78_RS04745	COG0635	Involved in the biosynthesis of porphyrin-containing compound
UC78_RS04760	COG0113	porphobilinogen synthase activity
UC78_RS04765	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
UC78_RS04780	COG2855	membrane
UC78_RS04785	COG0583	DNA-binding transcription factor activity
UC78_RS04790	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
UC78_RS04810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UC78_RS04815	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UC78_RS04855	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
UC78_RS04855	COG1333	cytochrome c biogenesis protein
UC78_RS04905	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
UC78_RS04910	COG2204	response regulator
UC78_RS04925	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
UC78_RS04940	COG0481	GTPase activity
UC78_RS04965	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
UC78_RS04975	COG0439	Biotin carboxylase
UC78_RS04980	COG0772	Belongs to the SEDS family
UC78_RS05005	COG0352	thiamine-phosphate diphosphorylase activity
UC78_RS05010	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
UC78_RS05015	COG2022	thiamine diphosphate biosynthetic process
UC78_RS05045	COG1193	negative regulation of DNA recombination
UC78_RS05075	COG0517	IMP dehydrogenase activity
UC78_RS05075	COG0516	GMP reductase activity
UC78_RS05080	COG0154	amidase activity
UC78_RS05090	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
UC78_RS05095	COG1058	Belongs to the CinA family
UC78_RS05095	COG1546	Belongs to the CinA family
UC78_RS05100	COG0456	acetyltransferase
UC78_RS05105	COG0778	Nitroreductase
UC78_RS05110	COG0778	Nitroreductase
UC78_RS05120	COG0750	zinc metalloprotease
UC78_RS05125	COG2990	Protein conserved in bacteria
UC78_RS05135	COG2271	Major facilitator Superfamily
UC78_RS05140	COG0360	Binds together with S18 to 16S ribosomal RNA
UC78_RS05145	COG0629	single-stranded DNA binding
UC78_RS05150	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
UC78_RS05155	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
UC78_RS05165	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
UC78_RS05170	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
UC78_RS05195	COG0352	thiamine-phosphate diphosphorylase activity
UC78_RS05215	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
UC78_RS05225	COG0739	heme binding
UC78_RS05230	COG0285	dihydrofolate synthase activity
UC78_RS05250	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UC78_RS05255	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
UC78_RS05260	COG1862	Preprotein translocase
UC78_RS05265	COG0815	Transfers the fatty acyl group on membrane lipoproteins
UC78_RS05270	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
UC78_RS05275	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
UC78_RS05295	COG0210	DNA helicase
UC78_RS05315	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
UC78_RS05325	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
UC78_RS05330	COG0542	response to heat
UC78_RS05335	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
UC78_RS05345	COG2095	MarC family integral membrane protein
UC78_RS05350	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
UC78_RS05355	COG2833	Protein of unknown function (DUF455)
UC78_RS05360	COG1183	phosphatidylcholine synthase activity
UC78_RS05370	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
UC78_RS05380	COG0745	RESPONSE REGULATOR receiver
UC78_RS05390	COG1086	Polysaccharide biosynthesis protein
UC78_RS05395	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
UC78_RS05400	COG0110	maltose O-acetyltransferase activity
UC78_RS05405	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
UC78_RS05410	COG0438	transferase activity, transferring glycosyl groups
UC78_RS05415	COG1287	oligosaccharyl transferase activity
UC78_RS05420	COG0438	transferase activity, transferring glycosyl groups
UC78_RS05425	COG1215	transferase activity, transferring glycosyl groups
UC78_RS05430	COG0438	transferase activity, transferring glycosyl groups
UC78_RS05435	COG1132	(ABC) transporter
UC78_RS05440	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
UC78_RS05450	COG0859	PFAM glycosyl transferase family 9
UC78_RS05455	COG1560	Kdo2-lipid A biosynthetic process
UC78_RS05460	COG0463	Glycosyl transferase, family 2
UC78_RS05465	COG0463	Glycosyl transferase, family 2
UC78_RS05470	COG1216	Glycosyl transferase, family 2
UC78_RS05470	COG1442	glycosyl transferase family 8
UC78_RS05485	COG1216	Glycosyl transferase, family 2
UC78_RS05510	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UC78_RS05515	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
UC78_RS05530	COG2217	Heavy metal translocating P-type atpase
UC78_RS05535	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
UC78_RS05540	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
UC78_RS05550	COG2217	Heavy metal translocating P-type atpase
UC78_RS05570	COG3610	response to peptide
UC78_RS05580	COG0039	L-malate dehydrogenase activity
UC78_RS05585	COG0586	Pfam SNARE associated Golgi protein
UC78_RS05600	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
UC78_RS05620	COG0018	arginyl-trna synthetase
UC78_RS05625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
UC78_RS05630	COG0194	GDP metabolic process
UC78_RS05640	COG1684	flagellar biosynthetic protein fliR
UC78_RS05650	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
UC78_RS05655	COG0052	Belongs to the universal ribosomal protein uS2 family
UC78_RS05660	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
UC78_RS05670	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
UC78_RS05675	COG0723	plastoquinol--plastocyanin reductase activity
UC78_RS05680	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
UC78_RS05685	COG0445	tRNA wobble uridine modification
UC78_RS05705	COG1301	dicarboxylic acid transport
UC78_RS05720	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
UC78_RS05730	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
UC78_RS05755	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
UC78_RS05770	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
UC78_RS05775	COG0552	protein localization to endoplasmic reticulum
UC78_RS05805	COG1295	ribonuclease BN
UC78_RS05810	COG0277	FAD linked oxidase domain protein
UC78_RS05820	COG0739	heme binding
UC78_RS05830	COG1496	oxidoreductase activity
UC78_RS05845	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
UC78_RS05855	COG0642	Histidine kinase
UC78_RS05860	COG0745	RESPONSE REGULATOR receiver
UC78_RS05865	COG2703	oxygen carrier activity
UC78_RS05880	COG0642	Histidine kinase
UC78_RS05885	COG0745	RESPONSE REGULATOR receiver
UC78_RS05890	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
UC78_RS05895	COG0484	heat shock protein binding
UC78_RS05900	COG0789	Transcriptional regulator
UC78_RS05905	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
UC78_RS05905	COG0475	glutathione-regulated potassium exporter activity
UC78_RS05915	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
UC78_RS05925	COG0739	heme binding
UC78_RS05935	COG0248	Ppx GppA phosphatase
UC78_RS05955	COG2814	Major facilitator Superfamily
UC78_RS05965	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
UC78_RS05970	COG0731	radical SAM domain protein
UC78_RS06015	COG1185	polyribonucleotide nucleotidyltransferase activity
UC78_RS06035	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
UC78_RS06040	COG4773	Receptor
UC78_RS06050	COG0745	RESPONSE REGULATOR receiver
UC78_RS06055	COG0642	Histidine kinase
UC78_RS06060	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
UC78_RS06065	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
UC78_RS06070	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
UC78_RS06075	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
UC78_RS06080	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
UC78_RS06085	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
UC78_RS06085	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
UC78_RS06100	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
UC78_RS06105	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
UC78_RS06110	COG1758	RNA polymerase activity
UC78_RS06115	COG0528	UMP kinase activity
UC78_RS06130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
UC78_RS06135	COG0220	tRNA (guanine-N7-)-methyltransferase activity
UC78_RS06145	COG0564	pseudouridine synthase activity
UC78_RS06150	COG0772	Belongs to the SEDS family
UC78_RS06165	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
UC78_RS06170	COG0569	domain protein
UC78_RS06175	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
UC78_RS06180	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
UC78_RS06185	COG0280	phosphate acetyltransferase
UC78_RS06185	COG0281	malic enzyme
UC78_RS06190	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
UC78_RS06195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
UC78_RS06200	COG0439	Biotin carboxylase
UC78_RS06205	COG0511	ligase activity, forming carbon-carbon bonds
UC78_RS06210	COG0717	Belongs to the dCTP deaminase family
UC78_RS06215	COG1086	Polysaccharide biosynthesis protein
UC78_RS06220	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
UC78_RS06225	COG4310	Domain of unknown function (DUF2172)
UC78_RS06240	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
UC78_RS06250	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
UC78_RS06285	COG1083	cytidylyl-transferase
UC78_RS06290	COG3980	spore coat polysaccharide biosynthesis protein
UC78_RS06295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
UC78_RS06300	COG0107	imidazoleglycerol-phosphate synthase activity
UC78_RS06305	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
UC78_RS06315	COG2089	acid synthase
UC78_RS06325	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UC78_RS06330	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
UC78_RS06340	COG2089	acid synthase
UC78_RS06345	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
UC78_RS06350	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
UC78_RS06360	COG1083	cytidylyl-transferase
UC78_RS06365	COG1028	Short-chain dehydrogenase reductase Sdr
UC78_RS06390	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UC78_RS06395	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
UC78_RS06415	COG2165	general secretion pathway protein
UC78_RS06420	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
UC78_RS06435	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
UC78_RS06440	COG0575	Belongs to the CDS family
UC78_RS06450	COG1293	RNA-binding protein homologous to eukaryotic snRNP
UC78_RS06455	COG0746	molybdenum cofactor guanylyltransferase activity
UC78_RS06460	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
UC78_RS06465	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UC78_RS06470	COG4605	iron ion homeostasis
UC78_RS06475	COG4604	ABC transporter, ATP-binding protein
UC78_RS06480	COG4607	ABC-type enterochelin transport system periplasmic component
UC78_RS06495	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
UC78_RS06500	COG3005	denitrification pathway
UC78_RS06535	COG0628	permease
UC78_RS06540	COG0114	fumarate hydratase activity
UC78_RS06545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
UC78_RS06555	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
UC78_RS06560	COG2252	PERMEase
UC78_RS06570	COG2853	Lipoprotein
UC78_RS06590	COG2814	Major facilitator Superfamily
UC78_RS06605	COG3276	selenocysteine insertion sequence binding
UC78_RS06620	COG0716	FMN binding
UC78_RS06635	COG0753	catalase activity
UC78_RS06645	COG2964	Protein conserved in bacteria
UC78_RS06650	COG0251	oxidation-reduction process
UC78_RS06655	COG3069	C4-dicarboxylate transmembrane transporter activity
UC78_RS06675	COG1918	ferrous iron import across plasma membrane
UC78_RS06680	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
UC78_RS06685	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
UC78_RS06690	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
UC78_RS06700	COG0126	phosphoglycerate kinase activity
UC78_RS06705	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
UC78_RS06730	COG1580	Controls the rotational direction of flagella during chemotaxis
UC78_RS06735	COG0736	holo-[acyl-carrier-protein] synthase activity
UC78_RS06745	COG2124	cytochrome p450
UC78_RS06765	COG0529	Catalyzes the synthesis of activated sulfate
UC78_RS06770	COG1213	nucleotidyl transferase
UC78_RS06775	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
UC78_RS06780	COG3848	Pyruvate phosphate dikinase
UC78_RS06780	COG0574	Belongs to the PEP-utilizing enzyme family
UC78_RS06785	COG2226	methyltransferase
UC78_RS06805	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
UC78_RS06825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
UC78_RS06845	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
UC78_RS06865	COG0517	IMP dehydrogenase activity
UC78_RS06865	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
UC78_RS06910	COG0037	tRNA processing
UC78_RS06915	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
UC78_RS06935	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
UC78_RS06960	COG3951	Flagellar rod assembly protein muramidase FlgJ
UC78_RS06985	COG0730	response to heat
UC78_RS06990	COG1459	type II secretion system
UC78_RS06995	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
UC78_RS07025	COG0546	phosphoglycolate phosphatase activity
UC78_RS07035	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
UC78_RS07040	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
UC78_RS07045	COG0210	DNA helicase
UC78_RS07050	COG2887	Belongs to the helicase family. UvrD subfamily
UC78_RS07095	COG0745	RESPONSE REGULATOR receiver
UC78_RS07110	COG0505	Belongs to the CarA family
UC78_RS07145	COG0425	Belongs to the sulfur carrier protein TusA family
UC78_RS07150	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
UC78_RS07160	COG0709	Synthesizes selenophosphate from selenide and ATP
UC78_RS07180	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
UC78_RS07190	COG0437	4 iron, 4 sulfur cluster binding
UC78_RS07200	COG3383	formate dehydrogenase (NAD+) activity
UC78_RS07230	COG0314	molybdopterin synthase activity
UC78_RS07235	COG0303	'Molybdopterin
UC78_RS07240	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
UC78_RS07250	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
UC78_RS07255	COG3069	C4-dicarboxylate transmembrane transporter activity
UC78_RS07260	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
UC78_RS07275	COG2992	FlgJ-related protein
UC78_RS07285	COG0783	Belongs to the Dps family
UC78_RS07290	COG0166	Belongs to the GPI family
UC78_RS07305	COG3839	Belongs to the ABC transporter superfamily
UC78_RS07310	COG4662	Binding-protein-dependent transport system inner membrane component
UC78_RS07315	COG2998	abc-type tungstate transport system, permease component
UC78_RS07325	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
UC78_RS07330	COG1984	allophanate hydrolase subunit 2
UC78_RS07340	COG2249	NAD(P)H dehydrogenase (quinone) activity
UC78_RS07360	COG1064	alcohol dehydrogenase
UC78_RS07400	COG2814	Major facilitator Superfamily
UC78_RS07405	COG0701	Predicted permease
UC78_RS07410	COG0640	Transcriptional regulator
UC78_RS07420	COG0798	PFAM Bile acid sodium symporter
UC78_RS07445	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UC78_RS07450	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
UC78_RS07460	COG0839	Belongs to the complex I subunit 6 family
UC78_RS07495	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UC78_RS07505	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
UC78_RS07520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
UC78_RS07525	COG0601	transmembrane transport
UC78_RS07535	COG0243	molybdopterin cofactor binding
UC78_RS07540	COG0437	4 iron, 4 sulfur cluster binding
UC78_RS07560	COG4615	Cyclic peptide transporter
UC78_RS07570	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
UC78_RS07575	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
UC78_RS07580	COG0257	Belongs to the bacterial ribosomal protein bL36 family
UC78_RS07590	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
UC78_RS07595	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
UC78_RS07600	COG0202	RNA polymerase activity
UC78_RS07605	COG0203	ribosomal protein L17
UC78_RS07610	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
UC78_RS07620	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
UC78_RS07620	COG0131	Imidazoleglycerol-phosphate dehydratase
UC78_RS07640	COG0140	phosphoribosyl-ATP diphosphatase activity
UC78_RS07640	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
UC78_RS07645	COG2171	N-acyltransferase activity
UC78_RS07650	COG0489	protein tyrosine kinase activity
UC78_RS07655	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
UC78_RS07655	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
UC78_RS07660	COG0745	RESPONSE REGULATOR receiver
UC78_RS07665	COG2046	Belongs to the sulfate adenylyltransferase family
UC78_RS07670	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
UC78_RS07675	COG0268	Binds directly to 16S ribosomal RNA
UC78_RS07680	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
UC78_RS07685	COG0748	coenzyme F420 binding
UC78_RS07690	COG4771	TonB-dependent receptor
UC78_RS07695	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
UC78_RS07700	COG1120	ATPase activity
UC78_RS07705	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
UC78_RS07715	COG0477	Major facilitator Superfamily
UC78_RS07720	COG1194	a g-specific adenine glycosylase
UC78_RS07750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UC78_RS07750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
UC78_RS07760	COG1760	l-serine dehydratase
UC78_RS07765	COG0814	amino acid
UC78_RS07780	COG0811	peptide transport
UC78_RS07785	COG0848	biopolymer transport protein
UC78_RS07810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
UC78_RS07820	COG0328	RNA-DNA hybrid ribonuclease activity
UC78_RS07830	COG0358	DNA primase activity
UC78_RS07845	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
UC78_RS07850	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
UC78_RS07865	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
UC78_RS07870	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
UC78_RS07875	COG1127	ABC transporter
UC78_RS07885	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
UC78_RS07885	COG3218	ABC-type transport auxiliary lipoprotein component
UC78_RS07895	COG0024	Methionine aminopeptidase
UC78_RS07900	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
UC78_RS07905	COG0791	NLP P60 protein
UC78_RS07910	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
UC78_RS07915	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
UC78_RS07930	COG0672	)-iron permease
UC78_RS07950	COG1136	(ABC) transporter
UC78_RS07950	COG0577	efflux transmembrane transporter activity
UC78_RS07955	COG1136	(ABC) transporter
UC78_RS08010	COG1793	dna ligase
UC78_RS08025	COG0148	phosphopyruvate hydratase activity
UC78_RS08030	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
UC78_RS08035	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
UC78_RS08040	COG1987	bacterial-type flagellum assembly
UC78_RS08055	COG1218	3'(2'),5'-bisphosphate nucleotidase
UC78_RS08060	COG0372	Belongs to the citrate synthase family
UC78_RS08075	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
UC78_RS08085	COG2936	dipeptidyl-peptidase activity
UC78_RS08095	COG0201	protein transport
UC78_RS08100	COG0200	Binds to the 23S rRNA
UC78_RS08105	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
UC78_RS08110	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
UC78_RS08115	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
UC78_RS08120	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
UC78_RS08125	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
UC78_RS08130	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
UC78_RS08135	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
UC78_RS08140	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
UC78_RS08145	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
UC78_RS08150	COG0255	Belongs to the universal ribosomal protein uL29 family
UC78_RS08155	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
UC78_RS08160	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
UC78_RS08170	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
UC78_RS08180	COG0089	rRNA binding
UC78_RS08185	COG0088	Forms part of the polypeptide exit tunnel
UC78_RS08190	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
UC78_RS08195	COG0051	transcription antitermination factor activity, RNA binding
UC78_RS08200	COG1187	pseudouridine synthase activity
UC78_RS08205	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
UC78_RS08220	COG0820	rRNA (adenine-C2-)-methyltransferase activity
UC78_RS08260	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
UC78_RS08265	COG0473	3-isopropylmalate dehydrogenase activity
UC78_RS08270	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
UC78_RS08285	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
UC78_RS08295	COG1749	Flagellar hook protein flgE
UC78_RS08300	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
UC78_RS08320	COG1216	Glycosyl transferase, family 2