locus-tag	class	description
E8M85_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E8M85_RS00010	COG0592	DNA-directed DNA polymerase activity
E8M85_RS00015	COG0187	DNA topoisomerase II activity
E8M85_RS00030	COG2056	Na+-H+ antiporter family
E8M85_RS00035	COG0070	glutamate synthase
E8M85_RS00035	COG0069	glutamate synthase activity
E8M85_RS00035	COG0067	glutamate synthase
E8M85_RS00040	COG0493	'glutamate synthase
E8M85_RS00045	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E8M85_RS00055	COG1592	Rubrerythrin
E8M85_RS00060	COG0129	dihydroxy-acid dehydratase activity
E8M85_RS00065	COG3477	response to acidic pH
E8M85_RS00075	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E8M85_RS00095	COG1858	cytochrome C peroxidase
E8M85_RS00100	COG0179	Fumarylacetoacetate (FAA) hydrolase
E8M85_RS00105	COG0564	pseudouridine synthase activity
E8M85_RS00110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E8M85_RS00115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E8M85_RS00130	COG0504	CTP synthase activity
E8M85_RS00140	COG0252	asparaginase activity
E8M85_RS00180	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
E8M85_RS00270	COG4383	Mu-like prophage protein gp29
E8M85_RS00315	COG4397	Mu-like prophage major head subunit gpT
E8M85_RS00460	COG2814	Major facilitator Superfamily
E8M85_RS00495	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E8M85_RS00535	COG0471	metal ion transport
E8M85_RS00540	COG0471	metal ion transport
E8M85_RS00580	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E8M85_RS00580	COG1776	CheC inhibitor of MCP methylation
E8M85_RS00585	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E8M85_RS00590	COG1191	sigma factor activity
E8M85_RS00600	COG0455	bacterial-type flagellum organization
E8M85_RS00605	COG1419	protein localization to endoplasmic reticulum
E8M85_RS00610	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E8M85_RS00615	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E8M85_RS00620	COG0402	S-adenosylhomocysteine deaminase activity
E8M85_RS00625	COG0616	signal peptide processing
E8M85_RS00650	COG1139	Iron-sulfur cluster binding protein
E8M85_RS00655	COG0247	lactate metabolic process
E8M85_RS00670	COG3021	interspecies interaction between organisms
E8M85_RS00685	COG1271	oxidase subunit
E8M85_RS00690	COG1294	oxidase, subunit
E8M85_RS00695	COG1794	racemase activity, acting on amino acids and derivatives
E8M85_RS00700	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
E8M85_RS00705	COG1027	Aspartate ammonia-lyase
E8M85_RS00710	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E8M85_RS00740	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E8M85_RS00745	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E8M85_RS00750	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
E8M85_RS00760	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
E8M85_RS00765	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E8M85_RS00765	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E8M85_RS00770	COG1192	Involved in chromosome partitioning
E8M85_RS00775	COG1475	DNA binding
E8M85_RS00785	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
E8M85_RS00790	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E8M85_RS00800	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
E8M85_RS00805	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E8M85_RS00810	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E8M85_RS00815	COG0811	peptide transport
E8M85_RS00820	COG0848	biopolymer transport protein
E8M85_RS00830	COG0823	Involved in the tonB-independent uptake of proteins
E8M85_RS00835	COG2885	chlorophyll binding
E8M85_RS00845	COG1047	Peptidyl-prolyl cis-trans
E8M85_RS00850	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E8M85_RS00855	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E8M85_RS00860	COG0037	tRNA processing
E8M85_RS00885	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E8M85_RS00895	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E8M85_RS00900	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E8M85_RS00905	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E8M85_RS00915	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E8M85_RS00930	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
E8M85_RS00940	COG0083	homoserine kinase activity
E8M85_RS00950	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
E8M85_RS00965	COG1401	restriction endodeoxyribonuclease activity
E8M85_RS00975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E8M85_RS00980	COG1121	(ABC) transporter
E8M85_RS00990	COG0840	transmembrane signaling receptor activity
E8M85_RS01000	COG0492	ferredoxin-NADP+ reductase activity
E8M85_RS01005	COG3118	belongs to the thioredoxin family
E8M85_RS01010	COG0792	nuclease activity
E8M85_RS01015	COG0460	homoserine dehydrogenase
E8M85_RS01020	COG0436	Aminotransferase
E8M85_RS01035	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E8M85_RS01040	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E8M85_RS01045	COG0254	rRNA binding
E8M85_RS01050	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E8M85_RS01070	COG0602	queuosine metabolic process
E8M85_RS01075	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E8M85_RS01100	COG1971	Probably functions as a manganese efflux pump
E8M85_RS01115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E8M85_RS01140	COG1840	ABC-type Fe3 transport system, periplasmic component
E8M85_RS01155	COG4206	TonB-dependent receptor
E8M85_RS01155	COG1629	transport
E8M85_RS01160	COG0811	peptide transport
E8M85_RS01165	COG0848	biopolymer transport protein
E8M85_RS01175	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E8M85_RS01180	COG1253	flavin adenine dinucleotide binding
E8M85_RS01190	COG2824	Alkylphosphonate utilization operon protein PhnA
E8M85_RS01195	COG0861	Integral membrane protein TerC family
E8M85_RS01200	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E8M85_RS01205	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E8M85_RS01205	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E8M85_RS01215	COG0606	chelatase, subunit chli
E8M85_RS01220	COG0242	peptide deformylase activity
E8M85_RS01230	COG0544	peptidyl-prolyl cis-trans isomerase activity
E8M85_RS01235	COG0302	gtp cyclohydrolase
E8M85_RS01240	COG1157	protein secretion by the type III secretion system
E8M85_RS01245	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E8M85_RS01250	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E8M85_RS01255	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E8M85_RS01255	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E8M85_RS01280	COG2851	Citrate transporter
E8M85_RS01285	COG1297	OPT oligopeptide transporter protein
E8M85_RS01290	COG1968	undecaprenyl-diphosphatase activity
E8M85_RS01295	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
E8M85_RS01300	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E8M85_RS01355	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E8M85_RS01360	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E8M85_RS01365	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E8M85_RS01380	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E8M85_RS01400	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E8M85_RS01405	COG0670	Belongs to the BI1 family
E8M85_RS01410	COG0288	reversible hydration of carbon dioxide
E8M85_RS01415	COG0668	transmembrane transport
E8M85_RS01440	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E8M85_RS01445	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E8M85_RS01475	COG0477	Major facilitator Superfamily
E8M85_RS01485	COG0315	cyclic pyranopterin monophosphate synthase activity
E8M85_RS01490	COG2921	Belongs to the UPF0250 family
E8M85_RS01500	COG0708	Exodeoxyribonuclease III
E8M85_RS01505	COG2194	sulfuric ester hydrolase activity
E8M85_RS01510	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E8M85_RS01520	COG0418	dihydroorotase activity
E8M85_RS01530	COG2226	methyltransferase
E8M85_RS01535	COG0840	transmembrane signaling receptor activity
E8M85_RS01540	COG0428	transporter
E8M85_RS01545	COG0243	molybdopterin cofactor binding
E8M85_RS01565	COG0330	HflC and HflK could
E8M85_RS01575	COG1942	4-Oxalocrotonate Tautomerase
E8M85_RS01580	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E8M85_RS01585	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E8M85_RS01590	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E8M85_RS01595	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E8M85_RS01600	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E8M85_RS01605	COG1077	Cell shape determining protein MreB Mrl
E8M85_RS01615	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E8M85_RS01635	COG0835	chemotaxis
E8M85_RS01640	COG2198	Histidine kinase
E8M85_RS01640	COG0643	Histidine kinase
E8M85_RS01640	COG0784	Response regulator, receiver
E8M85_RS01645	COG0835	chemotaxis
E8M85_RS01645	COG0784	Response regulator, receiver
E8M85_RS01660	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E8M85_RS01685	COG0454	-acetyltransferase
E8M85_RS01730	COG4106	trans-aconitate 2-methyltransferase activity
E8M85_RS01735	COG2830	Protein of unknown function (DUF452)
E8M85_RS01745	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E8M85_RS01750	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E8M85_RS01755	COG2076	Multidrug Resistance protein
E8M85_RS01780	COG0019	diaminopimelate decarboxylase activity
E8M85_RS01795	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E8M85_RS01805	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E8M85_RS01815	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E8M85_RS01830	COG2226	methyltransferase
E8M85_RS01835	COG1570	exodeoxyribonuclease VII activity
E8M85_RS01840	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E8M85_RS01845	COG0251	oxidation-reduction process
E8M85_RS01850	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E8M85_RS01855	COG0416	fatty acid biosynthetic process
E8M85_RS01860	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E8M85_RS01870	COG0105	UTP biosynthetic process
E8M85_RS01880	COG0450	alkyl hydroperoxide reductase
E8M85_RS01885	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E8M85_RS01890	COG1360	Flagellar Motor Protein
E8M85_RS01895	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E8M85_RS01905	COG0477	Major facilitator Superfamily
E8M85_RS01920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E8M85_RS01925	COG0730	response to heat
E8M85_RS01940	COG0512	Glutamine amidotransferase of anthranilate synthase
E8M85_RS01940	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E8M85_RS01950	COG0133	tryptophan synthase activity
E8M85_RS01965	COG1776	CheC inhibitor of MCP methylation
E8M85_RS01965	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E8M85_RS01980	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E8M85_RS01985	COG0745	RESPONSE REGULATOR receiver
E8M85_RS01995	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
E8M85_RS02010	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E8M85_RS02020	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E8M85_RS02030	COG1538	Outer membrane efflux protein
E8M85_RS02040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8M85_RS02055	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E8M85_RS02065	COG0754	glutathionylspermidine amidase activity
E8M85_RS02070	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E8M85_RS02075	COG1666	GTP binding
E8M85_RS02090	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E8M85_RS02100	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E8M85_RS02110	COG0284	orotidine-5'-phosphate decarboxylase activity
E8M85_RS02120	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E8M85_RS02150	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E8M85_RS02165	COG0469	pyruvate kinase activity
E8M85_RS02170	COG0579	oxidoreductase
E8M85_RS02175	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E8M85_RS02210	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E8M85_RS02215	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
E8M85_RS02230	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E8M85_RS02250	COG1053	succinate dehydrogenase
E8M85_RS02255	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E8M85_RS02300	COG2353	YceI-like domain
E8M85_RS02330	COG0488	(ABC) transporter
E8M85_RS02345	COG1739	Uncharacterized protein family UPF0029
E8M85_RS02385	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E8M85_RS02390	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
E8M85_RS02395	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
E8M85_RS02400	COG1028	Short-chain dehydrogenase reductase Sdr
E8M85_RS02410	COG1053	succinate dehydrogenase
E8M85_RS02415	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E8M85_RS02420	COG2048	Heterodisulfide reductase, subunit B
E8M85_RS02425	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E8M85_RS02430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E8M85_RS02435	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E8M85_RS02440	COG0825	malonyl-CoA metabolic process
E8M85_RS02455	COG4771	TonB-dependent receptor
E8M85_RS02475	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E8M85_RS02480	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E8M85_RS02510	COG2121	Domain of unknown function (DUF374)
E8M85_RS02515	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E8M85_RS02525	COG0195	Participates in both transcription termination and antitermination
E8M85_RS02535	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E8M85_RS02540	COG0612	Peptidase, M16
E8M85_RS02545	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E8M85_RS02550	COG2346	COG2346, Truncated hemoglobins
E8M85_RS02565	COG0765	amino acid transport
E8M85_RS02595	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E8M85_RS02600	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E8M85_RS02615	COG0250	Participates in transcription elongation, termination and antitermination
E8M85_RS02620	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E8M85_RS02625	COG0081	regulation of translation
E8M85_RS02630	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
E8M85_RS02635	COG0222	ribosome binding
E8M85_RS02640	COG0085	RNA polymerase activity
E8M85_RS02645	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
E8M85_RS02655	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E8M85_RS02665	COG2721	sulfolactate sulfo-lyase activity
E8M85_RS02675	COG1028	Short-chain dehydrogenase reductase Sdr
E8M85_RS02680	COG0738	Major facilitator superfamily
E8M85_RS02690	COG3254	rhamnose metabolic process
E8M85_RS02700	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E8M85_RS02705	COG0049	tRNA binding
E8M85_RS02750	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E8M85_RS02760	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
E8M85_RS02765	COG0673	inositol 2-dehydrogenase activity
E8M85_RS02775	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
E8M85_RS02780	COG0424	maF-like protein
E8M85_RS02790	COG0542	response to heat
E8M85_RS02795	COG1937	Protein conserved in bacteria
E8M85_RS02800	COG0793	Belongs to the peptidase S41A family
E8M85_RS02810	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E8M85_RS02815	COG0047	phosphoribosylformylglycinamidine synthase activity
E8M85_RS02825	COG0204	Acyl-transferase
E8M85_RS02830	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
E8M85_RS02840	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E8M85_RS02860	COG1677	Flagellar hook-basal body complex protein FliE
E8M85_RS02865	COG1558	bacterial-type flagellum-dependent cell motility
E8M85_RS02870	COG1815	bacterial-type flagellum-dependent cell motility
E8M85_RS02890	COG0039	L-malate dehydrogenase activity
E8M85_RS02900	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E8M85_RS02910	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E8M85_RS02910	COG0674	pyruvate-flavodoxin oxidoreductase activity
E8M85_RS02915	COG1013	pyruvate-flavodoxin oxidoreductase activity
E8M85_RS02935	COG0142	geranyltranstransferase activity
E8M85_RS02940	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E8M85_RS02945	COG0442	prolyl-tRNA aminoacylation
E8M85_RS02955	COG0181	hydroxymethylbilane synthase activity
E8M85_RS02960	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E8M85_RS02970	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E8M85_RS02990	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E8M85_RS03020	COG1289	transmembrane transporter activity
E8M85_RS03025	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E8M85_RS03030	COG0492	ferredoxin-NADP+ reductase activity
E8M85_RS03045	COG0305	Participates in initiation and elongation during chromosome replication
E8M85_RS03060	COG4735	regulation of single-species biofilm formation
E8M85_RS03065	COG4735	regulation of single-species biofilm formation
E8M85_RS03110	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E8M85_RS03110	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E8M85_RS03115	COG1610	YqeY-like protein
E8M85_RS03120	COG0028	Belongs to the TPP enzyme family
E8M85_RS03125	COG0440	acetolactate synthase activity
E8M85_RS03135	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
E8M85_RS03140	COG0805	protein transport
E8M85_RS03150	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E8M85_RS03155	COG0494	nUDIX hydrolase
E8M85_RS03160	COG0527	aspartate kinase activity
E8M85_RS03175	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E8M85_RS03180	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E8M85_RS03195	COG0196	riboflavin kinase activity
E8M85_RS03200	COG2890	protein-(glutamine-N5) methyltransferase activity
E8M85_RS03215	COG2860	membrane
E8M85_RS03225	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E8M85_RS03230	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E8M85_RS03235	COG0191	fructose-bisphosphate aldolase activity
E8M85_RS03255	COG0733	neurotransmitter:sodium symporter activity
E8M85_RS03260	COG2258	MOSC domain
E8M85_RS03275	COG1473	amidohydrolase
E8M85_RS03280	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8M85_RS03285	COG1136	(ABC) transporter
E8M85_RS03285	COG0577	efflux transmembrane transporter activity
E8M85_RS03290	COG1538	Outer membrane efflux protein
E8M85_RS03305	COG1696	Membrane protein involved in D-alanine export
E8M85_RS03310	COG1528	Iron-storage protein
E8M85_RS03315	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E8M85_RS03320	COG0573	inorganic phosphate transmembrane transporter activity
E8M85_RS03325	COG0581	inorganic phosphate transmembrane transporter activity
E8M85_RS03630	COG0534	Mate efflux family protein
E8M85_RS03645	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E8M85_RS03655	COG0298	carbon dioxide binding
E8M85_RS03660	COG0409	Hydrogenase expression formation protein
E8M85_RS03665	COG0309	Hydrogenase expression formation protein (HypE)
E8M85_RS03670	COG0375	protein maturation
E8M85_RS03690	COG0557	exoribonuclease II activity
E8M85_RS03695	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E8M85_RS03705	COG0758	DNA mediated transformation
E8M85_RS03725	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E8M85_RS03735	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E8M85_RS03740	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
E8M85_RS03745	COG0497	DNA recombination
E8M85_RS03755	COG0084	hydrolase, TatD family'
E8M85_RS03760	COG1388	LysM domain
E8M85_RS03760	COG0791	NLP P60 protein
E8M85_RS03765	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E8M85_RS03785	COG0218	Necessary for normal cell division and for the maintenance of normal septation
E8M85_RS03825	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E8M85_RS03830	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
E8M85_RS03845	COG0137	argininosuccinate synthase activity
E8M85_RS03850	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E8M85_RS03855	COG0802	atpase or kinase
E8M85_RS03860	COG1137	ATPase activity
E8M85_RS03865	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E8M85_RS03870	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E8M85_RS03885	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E8M85_RS03895	COG2205	protein histidine kinase activity
E8M85_RS03900	COG0556	nucleotide-excision repair
E8M85_RS03920	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E8M85_RS03930	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E8M85_RS03940	COG0280	phosphate acetyltransferase
E8M85_RS03965	COG0275	rRNA processing
E8M85_RS03970	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E8M85_RS03975	COG0849	cell division
E8M85_RS03980	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E8M85_RS03985	COG4786	Flagellar basal body rod
E8M85_RS03990	COG4786	Flagellar basal body rod
E8M85_RS03995	COG0174	glutamine synthetase
E8M85_RS04010	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E8M85_RS04020	COG0752	glycyl-tRNA synthetase alpha subunit
E8M85_RS04025	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E8M85_RS04035	COG1519	Transferase
E8M85_RS04035	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E8M85_RS04040	COG0564	pseudouridine synthase activity
E8M85_RS04045	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E8M85_RS04050	COG0228	four-way junction DNA binding
E8M85_RS04055	COG1837	Belongs to the UPF0109 family
E8M85_RS04060	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E8M85_RS04065	COG0336	Belongs to the RNA methyltransferase TrmD family
E8M85_RS04080	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E8M85_RS04085	COG1393	Belongs to the ArsC family
E8M85_RS04095	COG0587	DNA-directed DNA polymerase activity
E8M85_RS04100	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E8M85_RS04105	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E8M85_RS04115	COG2890	protein-(glutamine-N5) methyltransferase activity
E8M85_RS04120	COG0501	Belongs to the peptidase M48B family
E8M85_RS04130	COG0521	Mo-molybdopterin cofactor biosynthetic process
E8M85_RS04135	COG0598	Magnesium transport protein CorA
E8M85_RS04165	COG3842	ATPase activity
E8M85_RS04240	COG0675	Transposase, IS605 OrfB family
E8M85_RS04250	COG4771	TonB-dependent receptor
E8M85_RS04255	COG1420	regulation of RNA biosynthetic process
E8M85_RS04260	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E8M85_RS04265	COG0443	Heat shock 70 kDa protein
E8M85_RS04280	COG0436	Aminotransferase
E8M85_RS04285	COG1045	serine acetyltransferase
E8M85_RS04290	COG1166	arginine decarboxylase activity
E8M85_RS04305	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E8M85_RS04310	COG0163	prenyltransferase activity
E8M85_RS04320	COG1464	Belongs to the NlpA lipoprotein family
E8M85_RS04325	COG1464	Belongs to the NlpA lipoprotein family
E8M85_RS04330	COG1464	Belongs to the NlpA lipoprotein family
E8M85_RS04335	COG2011	ABC-type metal ion transport system permease component
E8M85_RS04340	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E8M85_RS04355	COG0210	DNA helicase
E8M85_RS04365	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E8M85_RS04370	COG0243	molybdopterin cofactor binding
E8M85_RS04375	COG0437	4 iron, 4 sulfur cluster binding
E8M85_RS04380	COG0348	domain, Protein
E8M85_RS04385	COG3043	anaerobic respiration
E8M85_RS04415	COG0617	tRNA 3'-terminal CCA addition
E8M85_RS04420	COG0788	formyltetrahydrofolate deformylase activity
E8M85_RS04425	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E8M85_RS04435	COG0642	Histidine kinase
E8M85_RS04460	COG1181	Belongs to the D-alanine--D-alanine ligase family
E8M85_RS04465	COG0632	four-way junction helicase activity
E8M85_RS04475	COG0728	peptidoglycan biosynthetic process
E8M85_RS04480	COG0215	cysteine-tRNA ligase activity
E8M85_RS04485	COG1132	(ABC) transporter
E8M85_RS04490	COG0167	dihydroorotate dehydrogenase activity
E8M85_RS04495	COG0612	Peptidase, M16
E8M85_RS04500	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E8M85_RS04505	COG1028	Short-chain dehydrogenase reductase Sdr
E8M85_RS04520	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E8M85_RS04525	COG1663	tetraacyldisaccharide 4'-kinase activity
E8M85_RS04530	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E8M85_RS04535	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E8M85_RS04550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E8M85_RS04565	COG1338	Plays a role in the flagellum-specific transport system
E8M85_RS04570	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E8M85_RS04600	COG0101	tRNA pseudouridine synthase activity
E8M85_RS04605	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E8M85_RS04620	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E8M85_RS04625	COG1757	Na H antiporter
E8M85_RS04630	COG4221	oxidoreductase activity
E8M85_RS04640	COG1049	propionate catabolic process, 2-methylcitrate cycle
E8M85_RS04645	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E8M85_RS04655	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E8M85_RS04655	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E8M85_RS04665	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E8M85_RS04690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
E8M85_RS04695	COG1408	metallophosphoesterase
E8M85_RS04700	COG0688	phosphatidylethanolamine metabolic process
E8M85_RS04745	COG0681	Belongs to the peptidase S26 family
E8M85_RS04750	COG0303	'Molybdopterin
E8M85_RS04765	COG0512	Glutamine amidotransferase of anthranilate synthase
E8M85_RS04765	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E8M85_RS04770	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E8M85_RS04775	COG0582	viral genome integration into host DNA
E8M85_RS04785	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E8M85_RS04820	COG2404	hydrolase activity, acting on ester bonds
E8M85_RS04825	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E8M85_RS04830	COG1959	2 iron, 2 sulfur cluster binding
E8M85_RS04835	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E8M85_RS04840	COG1196	nuclear chromosome segregation
E8M85_RS04840	COG1674	ftsk spoiiie
E8M85_RS04845	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E8M85_RS04865	COG5002	protein histidine kinase activity
E8M85_RS04870	COG0745	RESPONSE REGULATOR receiver
E8M85_RS04875	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E8M85_RS04885	COG1185	polyribonucleotide nucleotidyltransferase activity
E8M85_RS04885	COG0539	negative regulation of cytoplasmic translation
E8M85_RS04890	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E8M85_RS04895	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E8M85_RS04900	COG0072	phenylalanine-tRNA ligase activity
E8M85_RS04900	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E8M85_RS04905	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E8M85_RS04910	COG0537	adenosine 5'-monophosphoramidase activity
E8M85_RS04925	COG0765	amino acid transport
E8M85_RS04935	COG1115	amino acid carrier protein
E8M85_RS04940	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
E8M85_RS04945	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E8M85_RS04970	COG1999	signal sequence binding
E8M85_RS04975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E8M85_RS04980	COG0776	regulation of translation
E8M85_RS05000	COG1966	Carbon starvation protein
E8M85_RS05005	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E8M85_RS05010	COG0765	amino acid transport
E8M85_RS05015	COG0765	amino acid transport
E8M85_RS05020	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E8M85_RS05025	COG1126	abc transporter atp-binding protein
E8M85_RS05030	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E8M85_RS05035	COG2201	protein-glutamate methylesterase activity
E8M85_RS05060	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E8M85_RS05065	COG0012	GTP binding
E8M85_RS05070	COG0165	Argininosuccinate lyase
E8M85_RS05075	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E8M85_RS05080	COG5016	pyruvate
E8M85_RS05080	COG0511	ligase activity, forming carbon-carbon bonds
E8M85_RS05085	COG0733	neurotransmitter:sodium symporter activity
E8M85_RS05090	COG0733	neurotransmitter:sodium symporter activity
E8M85_RS05095	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E8M85_RS05155	COG0765	amino acid transport
E8M85_RS05165	COG0653	protein targeting
E8M85_RS05170	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E8M85_RS05180	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E8M85_RS05195	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E8M85_RS05245	COG0138	bifunctional purine biosynthesis protein purh
E8M85_RS05250	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E8M85_RS05270	COG0706	membrane insertase activity
E8M85_RS05275	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
E8M85_RS05285	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E8M85_RS05305	COG0824	Thioesterase
E8M85_RS05330	COG0500	methyltransferase
E8M85_RS05350	COG2195	Cleaves the N-terminal amino acid of tripeptides
E8M85_RS05355	COG0477	Major facilitator Superfamily
E8M85_RS05360	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E8M85_RS05370	COG3022	response to hydroperoxide
E8M85_RS05375	COG1473	amidohydrolase
E8M85_RS05380	COG2807	transmembrane transport
E8M85_RS05400	COG0247	lactate metabolic process
E8M85_RS05400	COG2181	nitrate reductase activity
E8M85_RS05405	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E8M85_RS05415	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E8M85_RS05420	COG0113	porphobilinogen synthase activity
E8M85_RS05425	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E8M85_RS05430	COG0357	Ribosomal RNA small subunit methyltransferase G
E8M85_RS05440	COG2855	membrane
E8M85_RS05445	COG0583	DNA-binding transcription factor activity
E8M85_RS05450	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E8M85_RS05470	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E8M85_RS05475	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E8M85_RS05495	COG0343	queuine tRNA-ribosyltransferase activity
E8M85_RS05515	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E8M85_RS05515	COG1333	cytochrome c biogenesis protein
E8M85_RS05565	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E8M85_RS05570	COG2204	response regulator
E8M85_RS05585	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E8M85_RS05600	COG0481	GTPase activity
E8M85_RS05625	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E8M85_RS05635	COG0439	Biotin carboxylase
E8M85_RS05640	COG0772	Belongs to the SEDS family
E8M85_RS05645	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E8M85_RS05665	COG0352	thiamine-phosphate diphosphorylase activity
E8M85_RS05670	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E8M85_RS05675	COG2022	thiamine diphosphate biosynthetic process
E8M85_RS05690	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E8M85_RS05710	COG1193	negative regulation of DNA recombination
E8M85_RS05740	COG0517	IMP dehydrogenase activity
E8M85_RS05740	COG0516	GMP reductase activity
E8M85_RS05755	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
E8M85_RS05760	COG1058	Belongs to the CinA family
E8M85_RS05760	COG1546	Belongs to the CinA family
E8M85_RS05775	COG0778	Nitroreductase
E8M85_RS05785	COG0750	zinc metalloprotease
E8M85_RS05790	COG2990	Protein conserved in bacteria
E8M85_RS05800	COG0629	single-stranded DNA binding
E8M85_RS05805	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E8M85_RS05810	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E8M85_RS05820	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
E8M85_RS05825	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E8M85_RS05850	COG0352	thiamine-phosphate diphosphorylase activity
E8M85_RS05870	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E8M85_RS05880	COG0739	heme binding
E8M85_RS05885	COG0285	dihydrofolate synthase activity
E8M85_RS05900	COG0495	leucyl-tRNA aminoacylation
E8M85_RS05905	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E8M85_RS05910	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E8M85_RS05915	COG1862	Preprotein translocase
E8M85_RS05920	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E8M85_RS05925	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E8M85_RS05930	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E8M85_RS05935	COG0540	Belongs to the ATCase OTCase family
E8M85_RS05950	COG0210	DNA helicase
E8M85_RS05955	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
E8M85_RS05970	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
E8M85_RS05985	COG0542	response to heat
E8M85_RS05990	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E8M85_RS06000	COG2095	MarC family integral membrane protein
E8M85_RS06005	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E8M85_RS06010	COG2833	Protein of unknown function (DUF455)
E8M85_RS06015	COG1183	phosphatidylcholine synthase activity
E8M85_RS06025	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E8M85_RS06035	COG0745	RESPONSE REGULATOR receiver
E8M85_RS06045	COG1086	Polysaccharide biosynthesis protein
E8M85_RS06050	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E8M85_RS06060	COG0110	maltose O-acetyltransferase activity
E8M85_RS06065	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E8M85_RS06070	COG0438	transferase activity, transferring glycosyl groups
E8M85_RS06075	COG1287	oligosaccharyl transferase activity
E8M85_RS06080	COG0438	transferase activity, transferring glycosyl groups
E8M85_RS06085	COG1215	transferase activity, transferring glycosyl groups
E8M85_RS06090	COG0438	transferase activity, transferring glycosyl groups
E8M85_RS06095	COG1132	(ABC) transporter
E8M85_RS06100	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E8M85_RS06110	COG0859	PFAM glycosyl transferase family 9
E8M85_RS06115	COG1560	Kdo2-lipid A biosynthetic process
E8M85_RS06120	COG0463	Glycosyl transferase, family 2
E8M85_RS06125	COG1442	glycosyl transferase family 8
E8M85_RS06125	COG1216	Glycosyl transferase, family 2
E8M85_RS06135	COG1442	glycosyl transferase family 8
E8M85_RS06135	COG1216	Glycosyl transferase, family 2
E8M85_RS06150	COG2089	acid synthase
E8M85_RS06175	COG1216	Glycosyl transferase, family 2
E8M85_RS06185	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E8M85_RS06190	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
E8M85_RS06190	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
E8M85_RS06200	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E8M85_RS06215	COG2217	Heavy metal translocating P-type atpase
E8M85_RS06220	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E8M85_RS06225	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E8M85_RS06240	COG2217	Heavy metal translocating P-type atpase
E8M85_RS06260	COG3610	response to peptide
E8M85_RS06275	COG0586	Pfam SNARE associated Golgi protein
E8M85_RS06290	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E8M85_RS06310	COG0018	arginyl-trna synthetase
E8M85_RS06315	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E8M85_RS06320	COG0194	GDP metabolic process
E8M85_RS06330	COG1684	flagellar biosynthetic protein fliR
E8M85_RS06345	COG0052	Belongs to the universal ribosomal protein uS2 family
E8M85_RS06350	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E8M85_RS06360	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E8M85_RS06365	COG0723	plastoquinol--plastocyanin reductase activity
E8M85_RS06370	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E8M85_RS06375	COG0445	tRNA wobble uridine modification
E8M85_RS06395	COG1301	dicarboxylic acid transport
E8M85_RS06410	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E8M85_RS06420	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
E8M85_RS06425	COG1854	S-ribosylhomocysteine lyase activity
E8M85_RS06445	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E8M85_RS06460	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E8M85_RS06465	COG0552	protein localization to endoplasmic reticulum
E8M85_RS06495	COG1295	ribonuclease BN
E8M85_RS06500	COG0277	FAD linked oxidase domain protein
E8M85_RS06510	COG0739	heme binding
E8M85_RS06535	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E8M85_RS06540	COG0459	protein refolding
E8M85_RS06545	COG0642	Histidine kinase
E8M85_RS06550	COG0745	RESPONSE REGULATOR receiver
E8M85_RS06570	COG0642	Histidine kinase
E8M85_RS06575	COG0745	RESPONSE REGULATOR receiver
E8M85_RS06580	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E8M85_RS06585	COG0484	heat shock protein binding
E8M85_RS06590	COG0789	Transcriptional regulator
E8M85_RS06595	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E8M85_RS06595	COG0475	glutathione-regulated potassium exporter activity
E8M85_RS06605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E8M85_RS06610	COG0751	glycine-tRNA ligase activity
E8M85_RS06615	COG0739	heme binding
E8M85_RS06625	COG0248	Ppx GppA phosphatase
E8M85_RS06630	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
E8M85_RS06645	COG2814	Major facilitator Superfamily
E8M85_RS06660	COG0731	radical SAM domain protein
E8M85_RS06725	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E8M85_RS06730	COG4773	Receptor
E8M85_RS06735	COG0484	heat shock protein binding
E8M85_RS06740	COG0745	RESPONSE REGULATOR receiver
E8M85_RS06745	COG0642	Histidine kinase
E8M85_RS06750	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E8M85_RS06755	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E8M85_RS06760	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
E8M85_RS06765	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E8M85_RS06770	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E8M85_RS06775	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
E8M85_RS06775	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
E8M85_RS06790	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
E8M85_RS06795	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E8M85_RS06800	COG1758	RNA polymerase activity
E8M85_RS06805	COG0528	UMP kinase activity
E8M85_RS06820	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E8M85_RS06825	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E8M85_RS06835	COG0564	pseudouridine synthase activity
E8M85_RS06840	COG0772	Belongs to the SEDS family
E8M85_RS06855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E8M85_RS06860	COG0569	domain protein
E8M85_RS06865	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
E8M85_RS06870	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E8M85_RS06875	COG0281	malic enzyme
E8M85_RS06890	COG0439	Biotin carboxylase
E8M85_RS06895	COG0511	ligase activity, forming carbon-carbon bonds
E8M85_RS06900	COG0717	Belongs to the dCTP deaminase family
E8M85_RS06905	COG1086	Polysaccharide biosynthesis protein
E8M85_RS06910	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E8M85_RS06915	COG4310	Domain of unknown function (DUF2172)
E8M85_RS06950	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E8M85_RS07000	COG1083	cytidylyl-transferase
E8M85_RS07005	COG3980	spore coat polysaccharide biosynthesis protein
E8M85_RS07010	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E8M85_RS07015	COG0107	imidazoleglycerol-phosphate synthase activity
E8M85_RS07020	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
E8M85_RS07030	COG2089	acid synthase
E8M85_RS07035	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E8M85_RS07040	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E8M85_RS07070	COG2089	acid synthase
E8M85_RS07075	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E8M85_RS07080	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E8M85_RS07090	COG1083	cytidylyl-transferase
E8M85_RS07095	COG1028	Short-chain dehydrogenase reductase Sdr
E8M85_RS07120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E8M85_RS07125	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E8M85_RS07145	COG2165	general secretion pathway protein
E8M85_RS07150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E8M85_RS07160	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
E8M85_RS07165	COG0575	Belongs to the CDS family
E8M85_RS07175	COG1293	RNA-binding protein homologous to eukaryotic snRNP
E8M85_RS07185	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
E8M85_RS07190	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E8M85_RS07195	COG4605	iron ion homeostasis
E8M85_RS07200	COG4604	ABC transporter, ATP-binding protein
E8M85_RS07205	COG4607	ABC-type enterochelin transport system periplasmic component
E8M85_RS07220	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E8M85_RS07225	COG3005	denitrification pathway
E8M85_RS07230	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
E8M85_RS07245	COG2255	four-way junction helicase activity
E8M85_RS07250	COG0628	permease
E8M85_RS07255	COG0114	fumarate hydratase activity
E8M85_RS07265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E8M85_RS07275	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E8M85_RS07280	COG2252	PERMEase
E8M85_RS07290	COG2853	Lipoprotein
E8M85_RS07305	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
E8M85_RS07310	COG2814	Major facilitator Superfamily
E8M85_RS07325	COG1921	L-seryl-tRNASec selenium transferase activity
E8M85_RS07330	COG3276	selenocysteine insertion sequence binding
E8M85_RS07345	COG0716	FMN binding
E8M85_RS07360	COG0753	catalase activity
E8M85_RS07370	COG2964	Protein conserved in bacteria
E8M85_RS07375	COG0251	oxidation-reduction process
E8M85_RS07400	COG1918	ferrous iron import across plasma membrane
E8M85_RS07405	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E8M85_RS07410	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E8M85_RS07415	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E8M85_RS07420	COG0149	triose-phosphate isomerase activity
E8M85_RS07425	COG0126	phosphoglycerate kinase activity
E8M85_RS07430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E8M85_RS07455	COG1580	Controls the rotational direction of flagella during chemotaxis
E8M85_RS07460	COG0736	holo-[acyl-carrier-protein] synthase activity
E8M85_RS07470	COG2124	cytochrome p450
E8M85_RS07490	COG0529	Catalyzes the synthesis of activated sulfate
E8M85_RS07495	COG1213	nucleotidyl transferase
E8M85_RS07500	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E8M85_RS07505	COG0574	Belongs to the PEP-utilizing enzyme family
E8M85_RS07505	COG3848	Pyruvate phosphate dikinase
E8M85_RS07510	COG2226	methyltransferase
E8M85_RS07570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E8M85_RS07605	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E8M85_RS07605	COG0517	IMP dehydrogenase activity
E8M85_RS07675	COG0585	pseudouridine synthase activity
E8M85_RS07680	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E8M85_RS07705	COG3951	Flagellar rod assembly protein muramidase FlgJ
E8M85_RS07730	COG0730	response to heat
E8M85_RS07735	COG1459	type II secretion system
E8M85_RS07770	COG0546	phosphoglycolate phosphatase activity
E8M85_RS07780	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E8M85_RS07785	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E8M85_RS07790	COG0210	DNA helicase
E8M85_RS07795	COG2887	Belongs to the helicase family. UvrD subfamily
E8M85_RS07840	COG0745	RESPONSE REGULATOR receiver
E8M85_RS07855	COG0505	Belongs to the CarA family
E8M85_RS07875	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E8M85_RS07890	COG0425	Belongs to the sulfur carrier protein TusA family
E8M85_RS07895	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E8M85_RS07925	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E8M85_RS07935	COG0437	4 iron, 4 sulfur cluster binding
E8M85_RS07970	COG0314	molybdopterin synthase activity
E8M85_RS07980	COG0303	'Molybdopterin
E8M85_RS07985	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E8M85_RS07995	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
E8M85_RS08010	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E8M85_RS08015	COG0237	dephospho-CoA kinase activity
E8M85_RS08020	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
E8M85_RS08025	COG2992	FlgJ-related protein
E8M85_RS08035	COG0783	Belongs to the Dps family
E8M85_RS08040	COG0166	Belongs to the GPI family
E8M85_RS08050	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E8M85_RS08055	COG3839	Belongs to the ABC transporter superfamily
E8M85_RS08060	COG4662	Binding-protein-dependent transport system inner membrane component
E8M85_RS08065	COG2998	abc-type tungstate transport system, permease component
E8M85_RS08070	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E8M85_RS08075	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E8M85_RS08080	COG1984	allophanate hydrolase subunit 2
E8M85_RS08090	COG2249	NAD(P)H dehydrogenase (quinone) activity
E8M85_RS08095	COG1733	regulation of RNA biosynthetic process
E8M85_RS08105	COG1064	alcohol dehydrogenase
E8M85_RS08110	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
E8M85_RS08130	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
E8M85_RS08140	COG2910	NAD(P)H-binding
E8M85_RS08145	COG1733	regulation of RNA biosynthetic process
E8M85_RS08180	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E8M85_RS08185	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E8M85_RS08195	COG0839	Belongs to the complex I subunit 6 family
E8M85_RS08200	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E8M85_RS08205	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E8M85_RS08230	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E8M85_RS08240	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E8M85_RS08255	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E8M85_RS08270	COG0277	FAD linked oxidase domain protein
E8M85_RS08280	COG4615	Cyclic peptide transporter
E8M85_RS08290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
E8M85_RS08295	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E8M85_RS08300	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E8M85_RS08310	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E8M85_RS08315	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
E8M85_RS08320	COG0202	RNA polymerase activity
E8M85_RS08325	COG0203	ribosomal protein L17
E8M85_RS08335	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
E8M85_RS08340	COG0131	Imidazoleglycerol-phosphate dehydratase
E8M85_RS08340	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E8M85_RS08350	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
E8M85_RS08365	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E8M85_RS08365	COG0140	phosphoribosyl-ATP diphosphatase activity
E8M85_RS08370	COG2171	N-acyltransferase activity
E8M85_RS08375	COG0489	protein tyrosine kinase activity
E8M85_RS08380	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E8M85_RS08380	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E8M85_RS08390	COG2046	Belongs to the sulfate adenylyltransferase family
E8M85_RS08395	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E8M85_RS08400	COG0268	Binds directly to 16S ribosomal RNA
E8M85_RS08405	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
E8M85_RS08410	COG0748	coenzyme F420 binding
E8M85_RS08415	COG4771	TonB-dependent receptor
E8M85_RS08420	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E8M85_RS08425	COG1120	ATPase activity
E8M85_RS08430	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E8M85_RS08440	COG0477	Major facilitator Superfamily
E8M85_RS08445	COG1194	a g-specific adenine glycosylase
E8M85_RS08475	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E8M85_RS08475	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E8M85_RS08485	COG1760	l-serine dehydratase
E8M85_RS08490	COG0814	amino acid
E8M85_RS08505	COG0811	peptide transport
E8M85_RS08510	COG0848	biopolymer transport protein
E8M85_RS08535	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E8M85_RS08540	COG0571	ribonuclease III activity
E8M85_RS08545	COG0328	RNA-DNA hybrid ribonuclease activity
E8M85_RS08555	COG0358	DNA primase activity
E8M85_RS08570	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E8M85_RS08575	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E8M85_RS08590	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E8M85_RS08595	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E8M85_RS08600	COG1127	ABC transporter
E8M85_RS08610	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E8M85_RS08610	COG3218	ABC-type transport auxiliary lipoprotein component
E8M85_RS08620	COG0024	Methionine aminopeptidase
E8M85_RS08625	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E8M85_RS08630	COG0791	NLP P60 protein
E8M85_RS08635	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E8M85_RS08640	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E8M85_RS08650	COG0672	)-iron permease
E8M85_RS08675	COG1136	(ABC) transporter
E8M85_RS08725	COG1793	dna ligase
E8M85_RS08740	COG0148	phosphopyruvate hydratase activity
E8M85_RS08745	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E8M85_RS08750	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
E8M85_RS08755	COG1987	bacterial-type flagellum assembly
E8M85_RS08785	COG1218	3'(2'),5'-bisphosphate nucleotidase
E8M85_RS08790	COG0372	Belongs to the citrate synthase family
E8M85_RS08800	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E8M85_RS08805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E8M85_RS08815	COG0201	protein transport
E8M85_RS08820	COG0200	Binds to the 23S rRNA
E8M85_RS08825	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E8M85_RS08830	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E8M85_RS08835	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E8M85_RS08840	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E8M85_RS08845	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E8M85_RS08850	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E8M85_RS08855	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E8M85_RS08860	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E8M85_RS08865	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E8M85_RS08870	COG0255	Belongs to the universal ribosomal protein uL29 family
E8M85_RS08875	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E8M85_RS08880	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E8M85_RS08890	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E8M85_RS08900	COG0089	rRNA binding
E8M85_RS08910	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E8M85_RS08915	COG0051	transcription antitermination factor activity, RNA binding
E8M85_RS08920	COG1187	pseudouridine synthase activity
E8M85_RS08925	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E8M85_RS08930	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
E8M85_RS08940	COG0820	rRNA (adenine-C2-)-methyltransferase activity
E8M85_RS08980	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E8M85_RS08985	COG0473	3-isopropylmalate dehydrogenase activity
E8M85_RS08990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
E8M85_RS09010	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E8M85_RS09020	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E8M85_RS09030	COG1749	Flagellar hook protein flgE
E8M85_RS09035	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group