locus-tag	class	description
A6J91_RS00025	COG0848	biopolymer transport protein
A6J91_RS00030	COG0811	peptide transport
A6J91_RS00045	COG0814	amino acid
A6J91_RS00050	COG1760	l-serine dehydratase
A6J91_RS00060	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6J91_RS00060	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
A6J91_RS00090	COG1194	a g-specific adenine glycosylase
A6J91_RS00095	COG0477	Major facilitator Superfamily
A6J91_RS00105	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
A6J91_RS00110	COG1120	ATPase activity
A6J91_RS00115	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J91_RS00120	COG4771	TonB-dependent receptor
A6J91_RS00125	COG0748	coenzyme F420 binding
A6J91_RS00130	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6J91_RS00135	COG0268	Binds directly to 16S ribosomal RNA
A6J91_RS00140	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6J91_RS00145	COG2046	Belongs to the sulfate adenylyltransferase family
A6J91_RS00155	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
A6J91_RS00155	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A6J91_RS00160	COG0489	protein tyrosine kinase activity
A6J91_RS00165	COG2171	N-acyltransferase activity
A6J91_RS00170	COG0140	phosphoribosyl-ATP diphosphatase activity
A6J91_RS00170	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
A6J91_RS00185	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
A6J91_RS00195	COG0131	Imidazoleglycerol-phosphate dehydratase
A6J91_RS00195	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6J91_RS00200	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
A6J91_RS00210	COG0203	ribosomal protein L17
A6J91_RS00215	COG0202	RNA polymerase activity
A6J91_RS00220	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6J91_RS00225	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6J91_RS00235	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6J91_RS00240	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6J91_RS00245	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
A6J91_RS00255	COG4615	Cyclic peptide transporter
A6J91_RS00265	COG0277	FAD linked oxidase domain protein
A6J91_RS00275	COG0601	transmembrane transport
A6J91_RS00280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6J91_RS00290	COG4608	Belongs to the ABC transporter superfamily
A6J91_RS00295	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J91_RS00300	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J91_RS00305	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J91_RS00330	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
A6J91_RS00335	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J91_RS00340	COG0839	Belongs to the complex I subunit 6 family
A6J91_RS00350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
A6J91_RS00355	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
A6J91_RS00390	COG1733	regulation of RNA biosynthetic process
A6J91_RS00395	COG2910	NAD(P)H-binding
A6J91_RS00405	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
A6J91_RS00425	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A6J91_RS00430	COG1064	alcohol dehydrogenase
A6J91_RS00440	COG1733	regulation of RNA biosynthetic process
A6J91_RS00445	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6J91_RS00455	COG1984	allophanate hydrolase subunit 2
A6J91_RS00460	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
A6J91_RS00465	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
A6J91_RS00470	COG2998	abc-type tungstate transport system, permease component
A6J91_RS00475	COG4662	Binding-protein-dependent transport system inner membrane component
A6J91_RS00480	COG3839	Belongs to the ABC transporter superfamily
A6J91_RS00485	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
A6J91_RS00495	COG0166	Belongs to the GPI family
A6J91_RS00500	COG0783	Belongs to the Dps family
A6J91_RS00510	COG2992	FlgJ-related protein
A6J91_RS00515	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6J91_RS00520	COG0237	dephospho-CoA kinase activity
A6J91_RS00525	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6J91_RS00540	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
A6J91_RS00550	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
A6J91_RS00555	COG0303	'Molybdopterin
A6J91_RS00560	COG0314	molybdopterin synthase activity
A6J91_RS00590	COG3383	formate dehydrogenase (NAD+) activity
A6J91_RS00600	COG0437	4 iron, 4 sulfur cluster binding
A6J91_RS00610	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
A6J91_RS00640	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
A6J91_RS00645	COG0425	Belongs to the sulfur carrier protein TusA family
A6J91_RS00660	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6J91_RS00680	COG0505	Belongs to the CarA family
A6J91_RS00695	COG0745	RESPONSE REGULATOR receiver
A6J91_RS00740	COG2887	Belongs to the helicase family. UvrD subfamily
A6J91_RS00745	COG0210	DNA helicase
A6J91_RS00750	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6J91_RS00755	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6J91_RS00765	COG0546	phosphoglycolate phosphatase activity
A6J91_RS00795	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6J91_RS00800	COG1459	type II secretion system
A6J91_RS00805	COG0730	response to heat
A6J91_RS00830	COG3951	Flagellar rod assembly protein muramidase FlgJ
A6J91_RS00835	COG1706	bacterial-type flagellum-dependent cell motility
A6J91_RS00855	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
A6J91_RS00860	COG0585	pseudouridine synthase activity
A6J91_RS00870	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A6J91_RS00875	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6J91_RS00880	COG0037	tRNA processing
A6J91_RS00925	COG0517	IMP dehydrogenase activity
A6J91_RS00925	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
A6J91_RS00940	COG1216	Glycosyl transferase, family 2
A6J91_RS00940	COG1442	glycosyl transferase family 8
A6J91_RS00945	COG0562	UDP-galactopyranose mutase
A6J91_RS00950	COG1216	Glycosyl transferase, family 2
A6J91_RS00955	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6J91_RS00970	COG1216	Glycosyl transferase, family 2
A6J91_RS01000	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J91_RS01020	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6J91_RS01045	COG2226	methyltransferase
A6J91_RS01050	COG3848	Pyruvate phosphate dikinase
A6J91_RS01050	COG0574	Belongs to the PEP-utilizing enzyme family
A6J91_RS01055	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A6J91_RS01060	COG1213	nucleotidyl transferase
A6J91_RS01065	COG0529	Catalyzes the synthesis of activated sulfate
A6J91_RS01085	COG2124	cytochrome p450
A6J91_RS01095	COG0736	holo-[acyl-carrier-protein] synthase activity
A6J91_RS01100	COG1580	Controls the rotational direction of flagella during chemotaxis
A6J91_RS01125	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
A6J91_RS01130	COG0126	phosphoglycerate kinase activity
A6J91_RS01135	COG0149	triose-phosphate isomerase activity
A6J91_RS01140	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6J91_RS01145	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A6J91_RS01150	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
A6J91_RS01155	COG1918	ferrous iron import across plasma membrane
A6J91_RS01175	COG3069	C4-dicarboxylate transmembrane transporter activity
A6J91_RS01180	COG3069	C4-dicarboxylate transmembrane transporter activity
A6J91_RS01185	COG3069	C4-dicarboxylate transmembrane transporter activity
A6J91_RS01190	COG0251	oxidation-reduction process
A6J91_RS01195	COG2964	Protein conserved in bacteria
A6J91_RS01205	COG0753	catalase activity
A6J91_RS01220	COG0716	FMN binding
A6J91_RS01235	COG3276	selenocysteine insertion sequence binding
A6J91_RS01240	COG1921	L-seryl-tRNASec selenium transferase activity
A6J91_RS01255	COG2814	Major facilitator Superfamily
A6J91_RS01260	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
A6J91_RS01275	COG2853	Lipoprotein
A6J91_RS01285	COG2252	PERMEase
A6J91_RS01290	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A6J91_RS01300	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6J91_RS01310	COG0114	fumarate hydratase activity
A6J91_RS01315	COG0628	permease
A6J91_RS01320	COG2255	four-way junction helicase activity
A6J91_RS01335	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
A6J91_RS01340	COG3005	denitrification pathway
A6J91_RS01345	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
A6J91_RS01360	COG4607	ABC-type enterochelin transport system periplasmic component
A6J91_RS01365	COG4604	ABC transporter, ATP-binding protein
A6J91_RS01370	COG4605	iron ion homeostasis
A6J91_RS01375	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6J91_RS01380	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
A6J91_RS01390	COG1293	RNA-binding protein homologous to eukaryotic snRNP
A6J91_RS01400	COG0575	Belongs to the CDS family
A6J91_RS01405	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
A6J91_RS01415	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6J91_RS01420	COG2165	general secretion pathway protein
A6J91_RS01440	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J91_RS01445	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J91_RS01475	COG1028	Short-chain dehydrogenase reductase Sdr
A6J91_RS01480	COG1083	cytidylyl-transferase
A6J91_RS01490	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
A6J91_RS01495	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A6J91_RS01500	COG2089	acid synthase
A6J91_RS01525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6J91_RS01530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J91_RS01545	COG2089	acid synthase
A6J91_RS01555	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
A6J91_RS01560	COG0107	imidazoleglycerol-phosphate synthase activity
A6J91_RS01565	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6J91_RS01570	COG3980	spore coat polysaccharide biosynthesis protein
A6J91_RS01575	COG1083	cytidylyl-transferase
A6J91_RS01620	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6J91_RS01655	COG4310	Domain of unknown function (DUF2172)
A6J91_RS01660	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6J91_RS01665	COG1086	Polysaccharide biosynthesis protein
A6J91_RS01670	COG0717	Belongs to the dCTP deaminase family
A6J91_RS01675	COG0511	ligase activity, forming carbon-carbon bonds
A6J91_RS01680	COG0439	Biotin carboxylase
A6J91_RS01690	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6J91_RS01695	COG0281	malic enzyme
A6J91_RS01695	COG0280	phosphate acetyltransferase
A6J91_RS01700	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6J91_RS01705	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A6J91_RS01710	COG0569	domain protein
A6J91_RS01715	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6J91_RS01730	COG0772	Belongs to the SEDS family
A6J91_RS01735	COG0564	pseudouridine synthase activity
A6J91_RS01745	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6J91_RS01750	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6J91_RS01765	COG0528	UMP kinase activity
A6J91_RS01770	COG1758	RNA polymerase activity
A6J91_RS01775	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6J91_RS01780	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6J91_RS01795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6J91_RS01795	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
A6J91_RS01800	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
A6J91_RS01805	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
A6J91_RS01810	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
A6J91_RS01815	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
A6J91_RS01820	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6J91_RS01825	COG0642	Histidine kinase
A6J91_RS01830	COG0745	RESPONSE REGULATOR receiver
A6J91_RS01835	COG0484	heat shock protein binding
A6J91_RS01845	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6J91_RS01860	COG1942	4-Oxalocrotonate Tautomerase
A6J91_RS01870	COG1185	polyribonucleotide nucleotidyltransferase activity
A6J91_RS01895	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6J91_RS01895	COG0519	Catalyzes the synthesis of GMP from XMP
A6J91_RS01905	COG0322	excinuclease ABC activity
A6J91_RS01915	COG0731	radical SAM domain protein
A6J91_RS01920	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
A6J91_RS01930	COG2814	Major facilitator Superfamily
A6J91_RS01940	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
A6J91_RS01945	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
A6J91_RS01950	COG0248	Ppx GppA phosphatase
A6J91_RS01960	COG0739	heme binding
A6J91_RS01965	COG0751	glycine-tRNA ligase activity
A6J91_RS01970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6J91_RS01980	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
A6J91_RS01980	COG0475	glutathione-regulated potassium exporter activity
A6J91_RS01985	COG0789	Transcriptional regulator
A6J91_RS01990	COG0484	heat shock protein binding
A6J91_RS01995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6J91_RS02000	COG0745	RESPONSE REGULATOR receiver
A6J91_RS02005	COG0642	Histidine kinase
A6J91_RS02025	COG0745	RESPONSE REGULATOR receiver
A6J91_RS02030	COG0642	Histidine kinase
A6J91_RS02035	COG0459	protein refolding
A6J91_RS02040	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6J91_RS02055	COG1496	oxidoreductase activity
A6J91_RS02065	COG0739	heme binding
A6J91_RS02075	COG0277	FAD linked oxidase domain protein
A6J91_RS02080	COG1295	ribonuclease BN
A6J91_RS02095	COG1418	mRNA catabolic process
A6J91_RS02110	COG0552	protein localization to endoplasmic reticulum
A6J91_RS02115	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
A6J91_RS02130	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
A6J91_RS02135	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
A6J91_RS02150	COG1854	S-ribosylhomocysteine lyase activity
A6J91_RS02155	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6J91_RS02165	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6J91_RS02180	COG1301	dicarboxylic acid transport
A6J91_RS02200	COG0445	tRNA wobble uridine modification
A6J91_RS02205	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
A6J91_RS02210	COG0723	plastoquinol--plastocyanin reductase activity
A6J91_RS02215	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
A6J91_RS02225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6J91_RS02230	COG0052	Belongs to the universal ribosomal protein uS2 family
A6J91_RS02235	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6J91_RS02245	COG1684	flagellar biosynthetic protein fliR
A6J91_RS02255	COG0194	GDP metabolic process
A6J91_RS02260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
A6J91_RS02265	COG0018	arginyl-trna synthetase
A6J91_RS02285	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6J91_RS02300	COG0586	Pfam SNARE associated Golgi protein
A6J91_RS02305	COG0039	L-malate dehydrogenase activity
A6J91_RS02315	COG3610	response to peptide
A6J91_RS02335	COG2217	Heavy metal translocating P-type atpase
A6J91_RS02355	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6J91_RS02360	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6J91_RS02365	COG2217	Heavy metal translocating P-type atpase
A6J91_RS02380	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
A6J91_RS02385	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6J91_RS02390	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
A6J91_RS02390	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
A6J91_RS02395	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
A6J91_RS02405	COG1216	Glycosyl transferase, family 2
A6J91_RS02425	COG2089	acid synthase
A6J91_RS02435	COG1442	glycosyl transferase family 8
A6J91_RS02435	COG1216	Glycosyl transferase, family 2
A6J91_RS02440	COG1442	glycosyl transferase family 8
A6J91_RS02440	COG1216	Glycosyl transferase, family 2
A6J91_RS02450	COG1216	Glycosyl transferase, family 2
A6J91_RS02450	COG1442	glycosyl transferase family 8
A6J91_RS02455	COG0463	Glycosyl transferase, family 2
A6J91_RS02460	COG1560	Kdo2-lipid A biosynthetic process
A6J91_RS02465	COG0859	PFAM glycosyl transferase family 9
A6J91_RS02475	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6J91_RS02480	COG1132	(ABC) transporter
A6J91_RS02485	COG0438	transferase activity, transferring glycosyl groups
A6J91_RS02490	COG1215	transferase activity, transferring glycosyl groups
A6J91_RS02495	COG0438	transferase activity, transferring glycosyl groups
A6J91_RS02500	COG1287	oligosaccharyl transferase activity
A6J91_RS02505	COG0438	transferase activity, transferring glycosyl groups
A6J91_RS02510	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6J91_RS02515	COG0110	maltose O-acetyltransferase activity
A6J91_RS02525	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6J91_RS02530	COG1086	Polysaccharide biosynthesis protein
A6J91_RS02540	COG0745	RESPONSE REGULATOR receiver
A6J91_RS02545	COG2264	protein methyltransferase activity
A6J91_RS02550	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6J91_RS02560	COG1183	phosphatidylcholine synthase activity
A6J91_RS02565	COG2833	Protein of unknown function (DUF455)
A6J91_RS02570	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J91_RS02575	COG2095	MarC family integral membrane protein
A6J91_RS02585	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
A6J91_RS02590	COG0542	response to heat
A6J91_RS02605	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6J91_RS02620	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6J91_RS02625	COG0210	DNA helicase
A6J91_RS02640	COG0540	Belongs to the ATCase OTCase family
A6J91_RS02645	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
A6J91_RS02650	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6J91_RS02655	COG0815	Transfers the fatty acyl group on membrane lipoproteins
A6J91_RS02660	COG1862	Preprotein translocase
A6J91_RS02665	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J91_RS02670	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
A6J91_RS02675	COG0495	leucyl-tRNA aminoacylation
A6J91_RS02690	COG0285	dihydrofolate synthase activity
A6J91_RS02695	COG0739	heme binding
A6J91_RS02705	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6J91_RS02725	COG0352	thiamine-phosphate diphosphorylase activity
A6J91_RS02750	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6J91_RS02755	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
A6J91_RS02765	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
A6J91_RS02770	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6J91_RS02775	COG0629	single-stranded DNA binding
A6J91_RS02780	COG0360	Binds together with S18 to 16S ribosomal RNA
A6J91_RS02785	COG2990	Protein conserved in bacteria
A6J91_RS02790	COG0750	zinc metalloprotease
A6J91_RS02800	COG0778	Nitroreductase
A6J91_RS02810	COG0456	acetyltransferase
A6J91_RS02815	COG1058	Belongs to the CinA family
A6J91_RS02815	COG1546	Belongs to the CinA family
A6J91_RS02820	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6J91_RS02830	COG0154	amidase activity
A6J91_RS02835	COG0517	IMP dehydrogenase activity
A6J91_RS02835	COG0516	GMP reductase activity
A6J91_RS02855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6J91_RS02865	COG1193	negative regulation of DNA recombination
A6J91_RS02875	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6J91_RS02885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6J91_RS02900	COG2022	thiamine diphosphate biosynthetic process
A6J91_RS02905	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6J91_RS02910	COG0352	thiamine-phosphate diphosphorylase activity
A6J91_RS02930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
A6J91_RS02935	COG0772	Belongs to the SEDS family
A6J91_RS02940	COG0439	Biotin carboxylase
A6J91_RS02950	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
A6J91_RS02975	COG0481	GTPase activity
A6J91_RS02990	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
A6J91_RS03005	COG2204	response regulator
A6J91_RS03010	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6J91_RS03060	COG1333	cytochrome c biogenesis protein
A6J91_RS03060	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
A6J91_RS03080	COG0343	queuine tRNA-ribosyltransferase activity
A6J91_RS03100	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6J91_RS03105	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6J91_RS03125	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6J91_RS03130	COG0583	DNA-binding transcription factor activity
A6J91_RS03135	COG2855	membrane
A6J91_RS03145	COG0357	Ribosomal RNA small subunit methyltransferase G
A6J91_RS03150	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6J91_RS03155	COG0113	porphobilinogen synthase activity
A6J91_RS03160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6J91_RS03170	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J91_RS03175	COG0247	lactate metabolic process
A6J91_RS03175	COG2181	nitrate reductase activity
A6J91_RS03195	COG2807	transmembrane transport
A6J91_RS03205	COG1473	amidohydrolase
A6J91_RS03210	COG3022	response to hydroperoxide
A6J91_RS03220	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J91_RS03225	COG0477	Major facilitator Superfamily
A6J91_RS03230	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6J91_RS03250	COG0500	methyltransferase
A6J91_RS03290	COG0824	Thioesterase
A6J91_RS03310	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6J91_RS03320	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A6J91_RS03325	COG0706	membrane insertase activity
A6J91_RS03335	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6J91_RS03340	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6J91_RS03345	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
A6J91_RS03350	COG0138	bifunctional purine biosynthesis protein purh
A6J91_RS03360	COG0840	transmembrane signaling receptor activity
A6J91_RS03375	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6J91_RS03390	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6J91_RS03400	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
A6J91_RS03405	COG0653	protein targeting
A6J91_RS03415	COG0765	amino acid transport
A6J91_RS03475	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6J91_RS03480	COG0733	neurotransmitter:sodium symporter activity
A6J91_RS03485	COG0733	neurotransmitter:sodium symporter activity
A6J91_RS03490	COG5016	pyruvate
A6J91_RS03490	COG0511	ligase activity, forming carbon-carbon bonds
A6J91_RS03495	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
A6J91_RS03500	COG0165	Argininosuccinate lyase
A6J91_RS03505	COG0012	GTP binding
A6J91_RS03510	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
A6J91_RS03520	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6J91_RS03535	COG2201	protein-glutamate methylesterase activity
A6J91_RS03540	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
A6J91_RS03545	COG1126	abc transporter atp-binding protein
A6J91_RS03550	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J91_RS03555	COG0765	amino acid transport
A6J91_RS03560	COG0765	amino acid transport
A6J91_RS03565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6J91_RS03570	COG1966	Carbon starvation protein
A6J91_RS03590	COG0776	regulation of translation
A6J91_RS03595	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6J91_RS03600	COG1999	signal sequence binding
A6J91_RS03625	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6J91_RS03630	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6J91_RS03635	COG1115	amino acid carrier protein
A6J91_RS03645	COG0765	amino acid transport
A6J91_RS03660	COG0537	adenosine 5'-monophosphoramidase activity
A6J91_RS03665	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6J91_RS03670	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J91_RS03670	COG0072	phenylalanine-tRNA ligase activity
A6J91_RS03675	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
A6J91_RS03680	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
A6J91_RS03685	COG0539	negative regulation of cytoplasmic translation
A6J91_RS03685	COG1185	polyribonucleotide nucleotidyltransferase activity
A6J91_RS03695	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
A6J91_RS03700	COG0745	RESPONSE REGULATOR receiver
A6J91_RS03705	COG5002	protein histidine kinase activity
A6J91_RS03710	COG0488	(ABC) transporter
A6J91_RS03725	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J91_RS03730	COG1196	nuclear chromosome segregation
A6J91_RS03730	COG1674	ftsk spoiiie
A6J91_RS03735	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6J91_RS03740	COG1959	2 iron, 2 sulfur cluster binding
A6J91_RS03745	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6J91_RS03750	COG2404	hydrolase activity, acting on ester bonds
A6J91_RS03780	COG3258	Cytochrome c
A6J91_RS03785	COG3258	Cytochrome c
A6J91_RS03800	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
A6J91_RS03810	COG0582	viral genome integration into host DNA
A6J91_RS03815	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
A6J91_RS03820	COG0512	Glutamine amidotransferase of anthranilate synthase
A6J91_RS03820	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6J91_RS03835	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6J91_RS03840	COG0303	'Molybdopterin
A6J91_RS03845	COG0681	Belongs to the peptidase S26 family
A6J91_RS03850	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6J91_RS03860	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
A6J91_RS03890	COG0688	phosphatidylethanolamine metabolic process
A6J91_RS03895	COG1408	metallophosphoesterase
A6J91_RS03900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6J91_RS03925	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
A6J91_RS03935	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J91_RS03935	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6J91_RS03945	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6J91_RS03950	COG1049	propionate catabolic process, 2-methylcitrate cycle
A6J91_RS03960	COG4221	oxidoreductase activity
A6J91_RS03965	COG1757	Na H antiporter
A6J91_RS03970	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6J91_RS03985	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
A6J91_RS03990	COG0101	tRNA pseudouridine synthase activity
A6J91_RS04020	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6J91_RS04025	COG1338	Plays a role in the flagellum-specific transport system
A6J91_RS04040	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6J91_RS04055	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
A6J91_RS04060	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
A6J91_RS04065	COG1663	tetraacyldisaccharide 4'-kinase activity
A6J91_RS04070	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6J91_RS04085	COG1028	Short-chain dehydrogenase reductase Sdr
A6J91_RS04090	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6J91_RS04095	COG0612	Peptidase, M16
A6J91_RS04100	COG0167	dihydroorotate dehydrogenase activity
A6J91_RS04105	COG1132	(ABC) transporter
A6J91_RS04110	COG0215	cysteine-tRNA ligase activity
A6J91_RS04115	COG0728	peptidoglycan biosynthetic process
A6J91_RS04125	COG0632	four-way junction helicase activity
A6J91_RS04130	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6J91_RS04155	COG0642	Histidine kinase
A6J91_RS04165	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6J91_RS04170	COG0788	formyltetrahydrofolate deformylase activity
A6J91_RS04205	COG3043	anaerobic respiration
A6J91_RS04210	COG0348	domain, Protein
A6J91_RS04215	COG0437	4 iron, 4 sulfur cluster binding
A6J91_RS04225	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
A6J91_RS04235	COG0210	DNA helicase
A6J91_RS04245	COG0525	valine-tRNA ligase activity
A6J91_RS04250	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6J91_RS04255	COG2011	ABC-type metal ion transport system permease component
A6J91_RS04260	COG1464	Belongs to the NlpA lipoprotein family
A6J91_RS04265	COG1464	Belongs to the NlpA lipoprotein family
A6J91_RS04270	COG1464	Belongs to the NlpA lipoprotein family
A6J91_RS04280	COG0163	prenyltransferase activity
A6J91_RS04285	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6J91_RS04300	COG1166	arginine decarboxylase activity
A6J91_RS04305	COG1045	serine acetyltransferase
A6J91_RS04310	COG0436	Aminotransferase
A6J91_RS04325	COG0443	Heat shock 70 kDa protein
A6J91_RS04330	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6J91_RS04335	COG1420	regulation of RNA biosynthetic process
A6J91_RS04340	COG4771	TonB-dependent receptor
A6J91_RS04350	COG0675	Transposase, IS605 OrfB family
A6J91_RS04430	COG3842	ATPase activity
A6J91_RS04460	COG0598	Magnesium transport protein CorA
A6J91_RS04465	COG0521	Mo-molybdopterin cofactor biosynthetic process
A6J91_RS04475	COG0501	Belongs to the peptidase M48B family
A6J91_RS04480	COG2890	protein-(glutamine-N5) methyltransferase activity
A6J91_RS04490	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
A6J91_RS04495	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6J91_RS04500	COG0587	DNA-directed DNA polymerase activity
A6J91_RS04510	COG1393	Belongs to the ArsC family
A6J91_RS04515	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
A6J91_RS04530	COG0336	Belongs to the RNA methyltransferase TrmD family
A6J91_RS04535	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6J91_RS04540	COG1837	Belongs to the UPF0109 family
A6J91_RS04545	COG0228	four-way junction DNA binding
A6J91_RS04550	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6J91_RS04555	COG0564	pseudouridine synthase activity
A6J91_RS04560	COG1519	Transferase
A6J91_RS04560	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6J91_RS04570	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6J91_RS04575	COG0752	glycyl-tRNA synthetase alpha subunit
A6J91_RS04585	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6J91_RS04590	COG0826	peptidase U32
A6J91_RS04600	COG0174	glutamine synthetase
A6J91_RS04605	COG4786	Flagellar basal body rod
A6J91_RS04610	COG4786	Flagellar basal body rod
A6J91_RS04615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
A6J91_RS04620	COG0849	cell division
A6J91_RS04625	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J91_RS04630	COG0275	rRNA processing
A6J91_RS04650	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6J91_RS04655	COG0280	phosphate acetyltransferase
A6J91_RS04665	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
A6J91_RS04675	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6J91_RS04695	COG0556	nucleotide-excision repair
A6J91_RS04710	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A6J91_RS04735	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6J91_RS04740	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A6J91_RS04745	COG1137	ATPase activity
A6J91_RS04750	COG0802	atpase or kinase
A6J91_RS04755	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6J91_RS04760	COG0137	argininosuccinate synthase activity
A6J91_RS04775	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6J91_RS04780	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6J91_RS04835	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6J91_RS04855	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
A6J91_RS04860	COG0791	NLP P60 protein
A6J91_RS04860	COG1388	LysM domain
A6J91_RS04865	COG0084	hydrolase, TatD family'
A6J91_RS04875	COG0497	DNA recombination
A6J91_RS04880	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6J91_RS04885	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6J91_RS04890	COG0563	adenylate kinase activity
A6J91_RS04895	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
A6J91_RS04900	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6J91_RS04915	COG0758	DNA mediated transformation
A6J91_RS04925	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
A6J91_RS04930	COG0557	exoribonuclease II activity
A6J91_RS04945	COG0375	protein maturation
A6J91_RS04950	COG0309	Hydrogenase expression formation protein (HypE)
A6J91_RS04955	COG0409	Hydrogenase expression formation protein
A6J91_RS04960	COG0298	carbon dioxide binding
A6J91_RS04970	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
A6J91_RS04985	COG0534	Mate efflux family protein
A6J91_RS05000	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6J91_RS05005	COG0581	inorganic phosphate transmembrane transporter activity
A6J91_RS05010	COG0573	inorganic phosphate transmembrane transporter activity
A6J91_RS05015	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A6J91_RS05020	COG1528	Iron-storage protein
A6J91_RS05025	COG1696	Membrane protein involved in D-alanine export
A6J91_RS05040	COG1538	Outer membrane efflux protein
A6J91_RS05045	COG1136	(ABC) transporter
A6J91_RS05045	COG0577	efflux transmembrane transporter activity
A6J91_RS05050	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J91_RS05055	COG1473	amidohydrolase
A6J91_RS05070	COG2258	MOSC domain
A6J91_RS05075	COG0733	neurotransmitter:sodium symporter activity
A6J91_RS05095	COG0191	fructose-bisphosphate aldolase activity
A6J91_RS05100	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6J91_RS05105	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6J91_RS05115	COG2860	membrane
A6J91_RS05130	COG2890	protein-(glutamine-N5) methyltransferase activity
A6J91_RS05135	COG0196	riboflavin kinase activity
A6J91_RS05150	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6J91_RS05155	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
A6J91_RS05170	COG0527	aspartate kinase activity
A6J91_RS05175	COG0494	nUDIX hydrolase
A6J91_RS05180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J91_RS05190	COG0805	protein transport
A6J91_RS05195	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6J91_RS05205	COG0440	acetolactate synthase activity
A6J91_RS05210	COG0028	Belongs to the TPP enzyme family
A6J91_RS05215	COG1610	YqeY-like protein
A6J91_RS05220	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6J91_RS05220	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
A6J91_RS05265	COG4735	regulation of single-species biofilm formation
A6J91_RS05280	COG0305	Participates in initiation and elongation during chromosome replication
A6J91_RS05295	COG0492	ferredoxin-NADP+ reductase activity
A6J91_RS05300	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6J91_RS05305	COG1289	transmembrane transporter activity
A6J91_RS05335	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6J91_RS05355	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
A6J91_RS05365	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
A6J91_RS05370	COG0181	hydroxymethylbilane synthase activity
A6J91_RS05380	COG0442	prolyl-tRNA aminoacylation
A6J91_RS05385	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
A6J91_RS05390	COG0142	geranyltranstransferase activity
A6J91_RS05410	COG1013	pyruvate-flavodoxin oxidoreductase activity
A6J91_RS05415	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
A6J91_RS05415	COG0674	pyruvate-flavodoxin oxidoreductase activity
A6J91_RS05425	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A6J91_RS05435	COG0039	L-malate dehydrogenase activity
A6J91_RS05455	COG1815	bacterial-type flagellum-dependent cell motility
A6J91_RS05460	COG1558	bacterial-type flagellum-dependent cell motility
A6J91_RS05465	COG1677	Flagellar hook-basal body complex protein FliE
A6J91_RS05495	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6J91_RS05500	COG0326	Molecular chaperone. Has ATPase activity
A6J91_RS05505	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
A6J91_RS05510	COG0204	Acyl-transferase
A6J91_RS05520	COG0047	phosphoribosylformylglycinamidine synthase activity
A6J91_RS05525	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6J91_RS05530	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6J91_RS05535	COG0793	Belongs to the peptidase S41A family
A6J91_RS05540	COG1937	Protein conserved in bacteria
A6J91_RS05545	COG0542	response to heat
A6J91_RS05555	COG0424	maF-like protein
A6J91_RS05560	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6J91_RS05570	COG0673	inositol 2-dehydrogenase activity
A6J91_RS05575	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
A6J91_RS05585	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
A6J91_RS05610	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6J91_RS05630	COG0049	tRNA binding
A6J91_RS05635	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6J91_RS05640	COG1012	belongs to the aldehyde dehydrogenase family
A6J91_RS05645	COG1012	belongs to the aldehyde dehydrogenase family
A6J91_RS05650	COG3254	rhamnose metabolic process
A6J91_RS05660	COG0738	Major facilitator superfamily
A6J91_RS05665	COG1028	Short-chain dehydrogenase reductase Sdr
A6J91_RS05675	COG2721	sulfolactate sulfo-lyase activity
A6J91_RS05685	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6J91_RS05695	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6J91_RS05700	COG0085	RNA polymerase activity
A6J91_RS05705	COG0222	ribosome binding
A6J91_RS05710	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6J91_RS05715	COG0081	regulation of translation
A6J91_RS05720	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6J91_RS05725	COG0250	Participates in transcription elongation, termination and antitermination
A6J91_RS05740	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6J91_RS05745	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6J91_RS05775	COG0765	amino acid transport
A6J91_RS05790	COG2346	COG2346, Truncated hemoglobins
A6J91_RS05795	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6J91_RS05800	COG0612	Peptidase, M16
A6J91_RS05805	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
A6J91_RS05815	COG0195	Participates in both transcription termination and antitermination
A6J91_RS05825	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
A6J91_RS05830	COG2121	Domain of unknown function (DUF374)
A6J91_RS05850	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
A6J91_RS05860	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6J91_RS05865	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6J91_RS05885	COG4771	TonB-dependent receptor
A6J91_RS05895	COG0825	malonyl-CoA metabolic process
A6J91_RS05900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6J91_RS05905	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6J91_RS05910	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A6J91_RS05915	COG2048	Heterodisulfide reductase, subunit B
A6J91_RS05920	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6J91_RS05925	COG1053	succinate dehydrogenase
A6J91_RS05935	COG1028	Short-chain dehydrogenase reductase Sdr
A6J91_RS05945	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
A6J91_RS05950	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6J91_RS05955	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
A6J91_RS05995	COG1739	Uncharacterized protein family UPF0029
A6J91_RS06010	COG0488	(ABC) transporter
A6J91_RS06040	COG2353	YceI-like domain
A6J91_RS06090	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
A6J91_RS06095	COG1053	succinate dehydrogenase
A6J91_RS06115	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6J91_RS06130	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6J91_RS06135	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6J91_RS06170	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
A6J91_RS06175	COG0579	oxidoreductase
A6J91_RS06180	COG0469	pyruvate kinase activity
A6J91_RS06195	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6J91_RS06225	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
A6J91_RS06235	COG0284	orotidine-5'-phosphate decarboxylase activity
A6J91_RS06245	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
A6J91_RS06255	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6J91_RS06270	COG1666	GTP binding
A6J91_RS06275	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6J91_RS06280	COG0754	glutathionylspermidine amidase activity
A6J91_RS06295	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6J91_RS06310	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
A6J91_RS06320	COG1538	Outer membrane efflux protein
A6J91_RS06330	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6J91_RS06335	COG1981	membrane
A6J91_RS06340	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6J91_RS06345	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6J91_RS06355	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6J91_RS06365	COG0745	RESPONSE REGULATOR receiver
A6J91_RS06370	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
A6J91_RS06385	COG1776	CheC inhibitor of MCP methylation
A6J91_RS06385	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6J91_RS06400	COG0133	tryptophan synthase activity
A6J91_RS06410	COG0512	Glutamine amidotransferase of anthranilate synthase
A6J91_RS06410	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
A6J91_RS06425	COG0730	response to heat
A6J91_RS06430	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6J91_RS06435	COG1238	metal cluster binding
A6J91_RS06445	COG0477	Major facilitator Superfamily
A6J91_RS06455	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
A6J91_RS06460	COG1360	Flagellar Motor Protein
A6J91_RS06465	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
A6J91_RS06470	COG0450	alkyl hydroperoxide reductase
A6J91_RS06480	COG0105	UTP biosynthetic process
A6J91_RS06490	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6J91_RS06495	COG0416	fatty acid biosynthetic process
A6J91_RS06500	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6J91_RS06505	COG0251	oxidation-reduction process
A6J91_RS06510	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
A6J91_RS06515	COG1570	exodeoxyribonuclease VII activity
A6J91_RS06520	COG2226	methyltransferase
A6J91_RS06535	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6J91_RS06545	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6J91_RS06555	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6J91_RS06570	COG0019	diaminopimelate decarboxylase activity
A6J91_RS06595	COG2076	Multidrug Resistance protein
A6J91_RS06600	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6J91_RS06605	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
A6J91_RS06615	COG2830	Protein of unknown function (DUF452)
A6J91_RS06620	COG4106	trans-aconitate 2-methyltransferase activity
A6J91_RS06665	COG0454	-acetyltransferase
A6J91_RS06695	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J91_RS06710	COG0835	chemotaxis
A6J91_RS06710	COG0784	Response regulator, receiver
A6J91_RS06715	COG2198	Histidine kinase
A6J91_RS06715	COG0784	Response regulator, receiver
A6J91_RS06715	COG0643	Histidine kinase
A6J91_RS06720	COG0835	chemotaxis
A6J91_RS06740	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6J91_RS06750	COG1077	Cell shape determining protein MreB Mrl
A6J91_RS06755	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6J91_RS06760	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
A6J91_RS06765	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6J91_RS06770	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6J91_RS06775	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
A6J91_RS06780	COG1942	4-Oxalocrotonate Tautomerase
A6J91_RS06790	COG0330	HflC and HflK could
A6J91_RS06810	COG0243	molybdopterin cofactor binding
A6J91_RS06815	COG0428	transporter
A6J91_RS06830	COG0492	ferredoxin-NADP+ reductase activity
A6J91_RS06835	COG3118	belongs to the thioredoxin family
A6J91_RS06840	COG0792	nuclease activity
A6J91_RS06845	COG0460	homoserine dehydrogenase
A6J91_RS06850	COG0436	Aminotransferase
A6J91_RS06865	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6J91_RS06870	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
A6J91_RS06875	COG0254	rRNA binding
A6J91_RS06880	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6J91_RS06900	COG0602	queuosine metabolic process
A6J91_RS06905	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
A6J91_RS06930	COG1971	Probably functions as a manganese efflux pump
A6J91_RS06945	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6J91_RS06970	COG1840	ABC-type Fe3 transport system, periplasmic component
A6J91_RS06985	COG4206	TonB-dependent receptor
A6J91_RS06985	COG1629	transport
A6J91_RS06990	COG0811	peptide transport
A6J91_RS06995	COG0848	biopolymer transport protein
A6J91_RS07005	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
A6J91_RS07010	COG1253	flavin adenine dinucleotide binding
A6J91_RS07020	COG2824	Alkylphosphonate utilization operon protein PhnA
A6J91_RS07025	COG0861	Integral membrane protein TerC family
A6J91_RS07030	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6J91_RS07035	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6J91_RS07035	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
A6J91_RS07045	COG0606	chelatase, subunit chli
A6J91_RS07050	COG0242	peptide deformylase activity
A6J91_RS07060	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6J91_RS07065	COG0302	gtp cyclohydrolase
A6J91_RS07070	COG1157	protein secretion by the type III secretion system
A6J91_RS07075	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
A6J91_RS07080	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6J91_RS07085	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
A6J91_RS07085	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6J91_RS07110	COG2851	Citrate transporter
A6J91_RS07115	COG1297	OPT oligopeptide transporter protein
A6J91_RS07120	COG1968	undecaprenyl-diphosphatase activity
A6J91_RS07125	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6J91_RS07130	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6J91_RS07170	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
A6J91_RS07180	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
A6J91_RS07185	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
A6J91_RS07190	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
A6J91_RS07195	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6J91_RS07205	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J91_RS07215	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6J91_RS07220	COG0233	cytoplasmic translational termination
A6J91_RS07225	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6J91_RS07230	COG0670	Belongs to the BI1 family
A6J91_RS07235	COG0288	reversible hydration of carbon dioxide
A6J91_RS07240	COG0668	transmembrane transport
A6J91_RS07265	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6J91_RS07270	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6J91_RS07275	COG0840	transmembrane signaling receptor activity
A6J91_RS07275	COG3290	protein histidine kinase activity
A6J91_RS07295	COG0477	Major facilitator Superfamily
A6J91_RS07305	COG0315	cyclic pyranopterin monophosphate synthase activity
A6J91_RS07310	COG2921	Belongs to the UPF0250 family
A6J91_RS07320	COG0708	Exodeoxyribonuclease III
A6J91_RS07325	COG2194	sulfuric ester hydrolase activity
A6J91_RS07330	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6J91_RS07340	COG0418	dihydroorotase activity
A6J91_RS07350	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6J91_RS07355	COG0840	transmembrane signaling receptor activity
A6J91_RS07365	COG1121	(ABC) transporter
A6J91_RS07370	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6J91_RS07380	COG1401	restriction endodeoxyribonuclease activity
A6J91_RS07395	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
A6J91_RS07405	COG0083	homoserine kinase activity
A6J91_RS07415	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A6J91_RS07430	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
A6J91_RS07440	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6J91_RS07445	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6J91_RS07450	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
A6J91_RS07460	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6J91_RS07485	COG0037	tRNA processing
A6J91_RS07490	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6J91_RS07495	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6J91_RS07500	COG1047	Peptidyl-prolyl cis-trans
A6J91_RS07510	COG2885	chlorophyll binding
A6J91_RS07515	COG0823	Involved in the tonB-independent uptake of proteins
A6J91_RS07525	COG0848	biopolymer transport protein
A6J91_RS07530	COG0811	peptide transport
A6J91_RS07535	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6J91_RS07540	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6J91_RS07545	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6J91_RS07555	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6J91_RS07560	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6J91_RS07570	COG1475	DNA binding
A6J91_RS07575	COG1192	Involved in chromosome partitioning
A6J91_RS07580	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6J91_RS07580	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6J91_RS07585	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6J91_RS07595	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6J91_RS07600	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6J91_RS07605	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6J91_RS07635	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
A6J91_RS07640	COG1027	Aspartate ammonia-lyase
A6J91_RS07645	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6J91_RS07650	COG1794	racemase activity, acting on amino acids and derivatives
A6J91_RS07655	COG1294	oxidase, subunit
A6J91_RS07660	COG1271	oxidase subunit
A6J91_RS07675	COG3021	interspecies interaction between organisms
A6J91_RS07690	COG0247	lactate metabolic process
A6J91_RS07695	COG1139	Iron-sulfur cluster binding protein
A6J91_RS07715	COG0616	signal peptide processing
A6J91_RS07720	COG0402	S-adenosylhomocysteine deaminase activity
A6J91_RS07725	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
A6J91_RS07730	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
A6J91_RS07735	COG1419	protein localization to endoplasmic reticulum
A6J91_RS07740	COG0455	bacterial-type flagellum organization
A6J91_RS07750	COG1191	sigma factor activity
A6J91_RS07755	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6J91_RS07760	COG1776	CheC inhibitor of MCP methylation
A6J91_RS07760	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
A6J91_RS07785	COG1611	Belongs to the LOG family
A6J91_RS07795	COG0471	metal ion transport
A6J91_RS07810	COG0471	metal ion transport
A6J91_RS07840	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
A6J91_RS07855	COG1217	gtp-binding protein TYPA
A6J91_RS07875	COG2814	Major facilitator Superfamily
A6J91_RS07925	COG0252	asparaginase activity
A6J91_RS07935	COG0504	CTP synthase activity
A6J91_RS07945	COG1823	symporter activity
A6J91_RS07950	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6J91_RS07955	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6J91_RS07960	COG0564	pseudouridine synthase activity
A6J91_RS07965	COG0179	Fumarylacetoacetate (FAA) hydrolase
A6J91_RS07970	COG1858	cytochrome C peroxidase
A6J91_RS07975	COG0840	transmembrane signaling receptor activity
A6J91_RS07990	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
A6J91_RS08000	COG3477	response to acidic pH
A6J91_RS08005	COG0129	dihydroxy-acid dehydratase activity
A6J91_RS08010	COG1592	Rubrerythrin
A6J91_RS08020	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6J91_RS08025	COG0493	'glutamate synthase
A6J91_RS08035	COG0070	glutamate synthase
A6J91_RS08035	COG0069	glutamate synthase activity
A6J91_RS08035	COG0067	glutamate synthase
A6J91_RS08040	COG2056	Na+-H+ antiporter family
A6J91_RS08055	COG0187	DNA topoisomerase II activity
A6J91_RS08060	COG0592	DNA-directed DNA polymerase activity
A6J91_RS08065	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6J91_RS08070	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
A6J91_RS08075	COG1749	Flagellar hook protein flgE
A6J91_RS08085	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
A6J91_RS08095	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
A6J91_RS08115	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
A6J91_RS08120	COG0473	3-isopropylmalate dehydrogenase activity
A6J91_RS08125	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
A6J91_RS08165	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6J91_RS08175	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6J91_RS08180	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
A6J91_RS08185	COG1187	pseudouridine synthase activity
A6J91_RS08190	COG0051	transcription antitermination factor activity, RNA binding
A6J91_RS08195	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6J91_RS08200	COG0088	Forms part of the polypeptide exit tunnel
A6J91_RS08205	COG0089	rRNA binding
A6J91_RS08215	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6J91_RS08225	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6J91_RS08230	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6J91_RS08235	COG0255	Belongs to the universal ribosomal protein uL29 family
A6J91_RS08240	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6J91_RS08245	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6J91_RS08250	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6J91_RS08255	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6J91_RS08260	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6J91_RS08265	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6J91_RS08270	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6J91_RS08275	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6J91_RS08280	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6J91_RS08285	COG0200	Binds to the 23S rRNA
A6J91_RS08290	COG0201	protein transport
A6J91_RS08300	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6J91_RS08305	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
A6J91_RS08315	COG0372	Belongs to the citrate synthase family
A6J91_RS08320	COG1218	3'(2'),5'-bisphosphate nucleotidase
A6J91_RS08340	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6J91_RS08345	COG1987	bacterial-type flagellum assembly
A6J91_RS08350	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
A6J91_RS08355	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6J91_RS08360	COG0148	phosphopyruvate hydratase activity
A6J91_RS08375	COG1793	dna ligase
A6J91_RS08425	COG1136	(ABC) transporter
A6J91_RS08450	COG0672	)-iron permease
A6J91_RS08465	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6J91_RS08470	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
A6J91_RS08475	COG0791	NLP P60 protein
A6J91_RS08480	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6J91_RS08485	COG0024	Methionine aminopeptidase
A6J91_RS08495	COG3218	ABC-type transport auxiliary lipoprotein component
A6J91_RS08495	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
A6J91_RS08505	COG1127	ABC transporter
A6J91_RS08510	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
A6J91_RS08515	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
A6J91_RS08530	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6J91_RS08535	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6J91_RS08550	COG0358	DNA primase activity
A6J91_RS08560	COG0328	RNA-DNA hybrid ribonuclease activity
A6J91_RS08565	COG0571	ribonuclease III activity
A6J91_RS08570	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system