locus-tag	class	description
D3Z18_RS00055	COG1971	Probably functions as a manganese efflux pump
D3Z18_RS00070	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
D3Z18_RS00090	COG1840	ABC-type Fe3 transport system, periplasmic component
D3Z18_RS00105	COG1629	transport
D3Z18_RS00105	COG4206	TonB-dependent receptor
D3Z18_RS00110	COG0811	peptide transport
D3Z18_RS00115	COG0848	biopolymer transport protein
D3Z18_RS00125	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
D3Z18_RS00130	COG1253	flavin adenine dinucleotide binding
D3Z18_RS00140	COG2824	Alkylphosphonate utilization operon protein PhnA
D3Z18_RS00145	COG0861	Integral membrane protein TerC family
D3Z18_RS00150	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
D3Z18_RS00165	COG0606	chelatase, subunit chli
D3Z18_RS00170	COG0242	peptide deformylase activity
D3Z18_RS00180	COG0544	peptidyl-prolyl cis-trans isomerase activity
D3Z18_RS00190	COG1157	protein secretion by the type III secretion system
D3Z18_RS00195	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
D3Z18_RS00200	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
D3Z18_RS00205	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
D3Z18_RS00205	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
D3Z18_RS00230	COG2851	Citrate transporter
D3Z18_RS00235	COG1297	OPT oligopeptide transporter protein
D3Z18_RS00240	COG1968	undecaprenyl-diphosphatase activity
D3Z18_RS00250	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
D3Z18_RS00300	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
D3Z18_RS00305	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
D3Z18_RS00310	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
D3Z18_RS00325	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3Z18_RS00345	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
D3Z18_RS00350	COG0670	Belongs to the BI1 family
D3Z18_RS00355	COG0288	reversible hydration of carbon dioxide
D3Z18_RS00360	COG0668	transmembrane transport
D3Z18_RS00385	COG0291	Belongs to the bacterial ribosomal protein bL35 family
D3Z18_RS00390	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
D3Z18_RS00410	COG0477	Major facilitator Superfamily
D3Z18_RS00420	COG0315	cyclic pyranopterin monophosphate synthase activity
D3Z18_RS00425	COG2921	Belongs to the UPF0250 family
D3Z18_RS00435	COG0708	Exodeoxyribonuclease III
D3Z18_RS00445	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
D3Z18_RS00455	COG0418	dihydroorotase activity
D3Z18_RS00465	COG2226	methyltransferase
D3Z18_RS00470	COG0840	transmembrane signaling receptor activity
D3Z18_RS00480	COG1121	(ABC) transporter
D3Z18_RS00485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
D3Z18_RS00495	COG1401	restriction endodeoxyribonuclease activity
D3Z18_RS00520	COG0083	homoserine kinase activity
D3Z18_RS00545	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
D3Z18_RS00555	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
D3Z18_RS00565	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
D3Z18_RS00575	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
D3Z18_RS00600	COG0037	tRNA processing
D3Z18_RS00605	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
D3Z18_RS00610	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
D3Z18_RS00615	COG1047	Peptidyl-prolyl cis-trans
D3Z18_RS00625	COG2885	chlorophyll binding
D3Z18_RS00630	COG0823	Involved in the tonB-independent uptake of proteins
D3Z18_RS00640	COG0848	biopolymer transport protein
D3Z18_RS00645	COG0811	peptide transport
D3Z18_RS00650	COG0355	proton-transporting ATP synthase activity, rotational mechanism
D3Z18_RS00655	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
D3Z18_RS00670	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
D3Z18_RS00685	COG1475	DNA binding
D3Z18_RS00690	COG1192	Involved in chromosome partitioning
D3Z18_RS00695	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
D3Z18_RS00695	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
D3Z18_RS00715	COG0211	Belongs to the bacterial ribosomal protein bL27 family
D3Z18_RS00720	COG0261	This protein binds to 23S rRNA in the presence of protein L20
D3Z18_RS00750	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D3Z18_RS00755	COG1027	Aspartate ammonia-lyase
D3Z18_RS00765	COG1794	racemase activity, acting on amino acids and derivatives
D3Z18_RS00770	COG1294	oxidase, subunit
D3Z18_RS00775	COG1271	oxidase subunit
D3Z18_RS00790	COG3021	interspecies interaction between organisms
D3Z18_RS00805	COG0247	lactate metabolic process
D3Z18_RS00810	COG1139	Iron-sulfur cluster binding protein
D3Z18_RS00830	COG0616	signal peptide processing
D3Z18_RS00835	COG0402	S-adenosylhomocysteine deaminase activity
D3Z18_RS00840	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
D3Z18_RS00845	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
D3Z18_RS00850	COG1419	protein localization to endoplasmic reticulum
D3Z18_RS00855	COG0455	bacterial-type flagellum organization
D3Z18_RS00865	COG1191	sigma factor activity
D3Z18_RS00870	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3Z18_RS00875	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3Z18_RS00875	COG1776	CheC inhibitor of MCP methylation
D3Z18_RS00915	COG0471	metal ion transport
D3Z18_RS00920	COG0471	metal ion transport
D3Z18_RS00930	COG0471	metal ion transport
D3Z18_RS00960	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
D3Z18_RS00975	COG1217	gtp-binding protein TYPA
D3Z18_RS00995	COG2814	Major facilitator Superfamily
D3Z18_RS01050	COG0252	asparaginase activity
D3Z18_RS01060	COG0504	CTP synthase activity
D3Z18_RS01075	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
D3Z18_RS01080	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
D3Z18_RS01085	COG0564	pseudouridine synthase activity
D3Z18_RS01090	COG0179	Fumarylacetoacetate (FAA) hydrolase
D3Z18_RS01095	COG1858	cytochrome C peroxidase
D3Z18_RS01100	COG0840	transmembrane signaling receptor activity
D3Z18_RS01115	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
D3Z18_RS01130	COG0129	dihydroxy-acid dehydratase activity
D3Z18_RS01135	COG1592	Rubrerythrin
D3Z18_RS01145	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
D3Z18_RS01150	COG0493	'glutamate synthase
D3Z18_RS01155	COG0067	glutamate synthase
D3Z18_RS01155	COG0069	glutamate synthase activity
D3Z18_RS01155	COG0070	glutamate synthase
D3Z18_RS01160	COG2056	Na+-H+ antiporter family
D3Z18_RS01175	COG0187	DNA topoisomerase II activity
D3Z18_RS01180	COG0592	DNA-directed DNA polymerase activity
D3Z18_RS01185	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
D3Z18_RS01195	COG1749	Flagellar hook protein flgE
D3Z18_RS01205	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
D3Z18_RS01230	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
D3Z18_RS01295	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
D3Z18_RS01300	COG1187	pseudouridine synthase activity
D3Z18_RS01305	COG0051	transcription antitermination factor activity, RNA binding
D3Z18_RS01310	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
D3Z18_RS01320	COG0089	rRNA binding
D3Z18_RS01330	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
D3Z18_RS01340	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
D3Z18_RS01345	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
D3Z18_RS01350	COG0255	Belongs to the universal ribosomal protein uL29 family
D3Z18_RS01355	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
D3Z18_RS01360	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
D3Z18_RS01365	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
D3Z18_RS01370	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
D3Z18_RS01375	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
D3Z18_RS01380	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
D3Z18_RS01385	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
D3Z18_RS01390	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
D3Z18_RS01395	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
D3Z18_RS01400	COG0200	Binds to the 23S rRNA
D3Z18_RS01405	COG0201	protein transport
D3Z18_RS01410	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
D3Z18_RS01435	COG1175	transmembrane transport
D3Z18_RS01450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
D3Z18_RS01465	COG0372	Belongs to the citrate synthase family
D3Z18_RS01470	COG1218	3'(2'),5'-bisphosphate nucleotidase
D3Z18_RS01485	COG1987	bacterial-type flagellum assembly
D3Z18_RS01490	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D3Z18_RS01495	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
D3Z18_RS01500	COG0148	phosphopyruvate hydratase activity
D3Z18_RS01515	COG1793	dna ligase
D3Z18_RS01565	COG1136	(ABC) transporter
D3Z18_RS01590	COG0672	)-iron permease
D3Z18_RS01605	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
D3Z18_RS01615	COG0791	NLP P60 protein
D3Z18_RS01620	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
D3Z18_RS01625	COG0024	Methionine aminopeptidase
D3Z18_RS01635	COG3218	ABC-type transport auxiliary lipoprotein component
D3Z18_RS01635	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
D3Z18_RS01645	COG1127	ABC transporter
D3Z18_RS01650	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
D3Z18_RS01655	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
D3Z18_RS01670	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
D3Z18_RS01675	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
D3Z18_RS01690	COG0358	DNA primase activity
D3Z18_RS01700	COG0328	RNA-DNA hybrid ribonuclease activity
D3Z18_RS01705	COG0571	ribonuclease III activity
D3Z18_RS01710	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
D3Z18_RS01735	COG0848	biopolymer transport protein
D3Z18_RS01740	COG0811	peptide transport
D3Z18_RS01755	COG0814	amino acid
D3Z18_RS01760	COG1760	l-serine dehydratase
D3Z18_RS01800	COG1194	a g-specific adenine glycosylase
D3Z18_RS01805	COG0477	Major facilitator Superfamily
D3Z18_RS01815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
D3Z18_RS01820	COG1120	ATPase activity
D3Z18_RS01825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3Z18_RS01835	COG0748	coenzyme F420 binding
D3Z18_RS01840	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
D3Z18_RS01845	COG0268	Binds directly to 16S ribosomal RNA
D3Z18_RS01850	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
D3Z18_RS01855	COG2046	Belongs to the sulfate adenylyltransferase family
D3Z18_RS01865	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
D3Z18_RS01865	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
D3Z18_RS01870	COG0489	protein tyrosine kinase activity
D3Z18_RS01875	COG2171	N-acyltransferase activity
D3Z18_RS01880	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
D3Z18_RS01880	COG0140	phosphoribosyl-ATP diphosphatase activity
D3Z18_RS01905	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D3Z18_RS01905	COG0131	Imidazoleglycerol-phosphate dehydratase
D3Z18_RS01920	COG0203	ribosomal protein L17
D3Z18_RS01925	COG0202	RNA polymerase activity
D3Z18_RS01935	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
D3Z18_RS01945	COG0257	Belongs to the bacterial ribosomal protein bL36 family
D3Z18_RS01950	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
D3Z18_RS01965	COG4615	Cyclic peptide transporter
D3Z18_RS01975	COG0277	FAD linked oxidase domain protein
D3Z18_RS01985	COG0601	transmembrane transport
D3Z18_RS01990	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
D3Z18_RS02005	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3Z18_RS02015	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3Z18_RS02050	COG0839	Belongs to the complex I subunit 6 family
D3Z18_RS02060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
D3Z18_RS02065	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
D3Z18_RS02090	COG0798	PFAM Bile acid sodium symporter
D3Z18_RS02100	COG0640	Transcriptional regulator
D3Z18_RS02120	COG2814	Major facilitator Superfamily
D3Z18_RS02145	COG0732	type I restriction modification DNA specificity domain
D3Z18_RS02160	COG1064	alcohol dehydrogenase
D3Z18_RS02170	COG1733	regulation of RNA biosynthetic process
D3Z18_RS02175	COG2249	NAD(P)H dehydrogenase (quinone) activity
D3Z18_RS02185	COG1984	allophanate hydrolase subunit 2
D3Z18_RS02190	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
D3Z18_RS02195	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
D3Z18_RS02200	COG2998	abc-type tungstate transport system, permease component
D3Z18_RS02205	COG4662	Binding-protein-dependent transport system inner membrane component
D3Z18_RS02210	COG3839	Belongs to the ABC transporter superfamily
D3Z18_RS02215	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
D3Z18_RS02225	COG0166	Belongs to the GPI family
D3Z18_RS02230	COG0783	Belongs to the Dps family
D3Z18_RS02240	COG2992	FlgJ-related protein
D3Z18_RS02255	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
D3Z18_RS02295	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
D3Z18_RS02300	COG0303	'Molybdopterin
D3Z18_RS02305	COG0314	molybdopterin synthase activity
D3Z18_RS02335	COG3383	formate dehydrogenase (NAD+) activity
D3Z18_RS02345	COG0437	4 iron, 4 sulfur cluster binding
D3Z18_RS02355	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
D3Z18_RS02385	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
D3Z18_RS02390	COG0425	Belongs to the sulfur carrier protein TusA family
D3Z18_RS02405	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
D3Z18_RS02425	COG0505	Belongs to the CarA family
D3Z18_RS02440	COG0745	RESPONSE REGULATOR receiver
D3Z18_RS02485	COG2887	Belongs to the helicase family. UvrD subfamily
D3Z18_RS02490	COG0210	DNA helicase
D3Z18_RS02495	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
D3Z18_RS02500	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
D3Z18_RS02510	COG0546	phosphoglycolate phosphatase activity
D3Z18_RS02865	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
D3Z18_RS02870	COG0602	queuosine metabolic process
D3Z18_RS02890	COG1385	rRNA (uridine-N3-)-methyltransferase activity
D3Z18_RS02895	COG0254	rRNA binding
D3Z18_RS02900	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
D3Z18_RS02905	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
D3Z18_RS02920	COG0436	Aminotransferase
D3Z18_RS02925	COG0460	homoserine dehydrogenase
D3Z18_RS02930	COG0792	nuclease activity
D3Z18_RS02935	COG3118	belongs to the thioredoxin family
D3Z18_RS02940	COG0492	ferredoxin-NADP+ reductase activity
D3Z18_RS02960	COG0840	transmembrane signaling receptor activity
D3Z18_RS02965	COG0428	transporter
D3Z18_RS02985	COG0330	HflC and HflK could
D3Z18_RS02995	COG1942	4-Oxalocrotonate Tautomerase
D3Z18_RS03000	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
D3Z18_RS03005	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
D3Z18_RS03020	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
D3Z18_RS03025	COG1077	Cell shape determining protein MreB Mrl
D3Z18_RS03035	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D3Z18_RS03055	COG0835	chemotaxis
D3Z18_RS03060	COG2198	Histidine kinase
D3Z18_RS03060	COG0643	Histidine kinase
D3Z18_RS03060	COG0784	Response regulator, receiver
D3Z18_RS03065	COG0835	chemotaxis
D3Z18_RS03065	COG0784	Response regulator, receiver
D3Z18_RS03110	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
D3Z18_RS03145	COG4106	trans-aconitate 2-methyltransferase activity
D3Z18_RS03150	COG2830	Protein of unknown function (DUF452)
D3Z18_RS03160	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
D3Z18_RS03165	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
D3Z18_RS03170	COG2076	Multidrug Resistance protein
D3Z18_RS03195	COG0019	diaminopimelate decarboxylase activity
D3Z18_RS03210	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
D3Z18_RS03220	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3Z18_RS03365	COG4397	Mu-like prophage major head subunit gpT
D3Z18_RS03410	COG4383	Mu-like prophage protein gp29
D3Z18_RS03500	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
D3Z18_RS03510	COG2226	methyltransferase
D3Z18_RS03515	COG1570	exodeoxyribonuclease VII activity
D3Z18_RS03520	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
D3Z18_RS03525	COG0251	oxidation-reduction process
D3Z18_RS03540	COG0333	Belongs to the bacterial ribosomal protein bL32 family
D3Z18_RS03560	COG0450	alkyl hydroperoxide reductase
D3Z18_RS03565	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3Z18_RS03570	COG1360	Flagellar Motor Protein
D3Z18_RS03575	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
D3Z18_RS03585	COG0477	Major facilitator Superfamily
D3Z18_RS03595	COG1238	metal cluster binding
D3Z18_RS03615	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
D3Z18_RS03620	COG0730	response to heat
D3Z18_RS03635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D3Z18_RS03635	COG0512	Glutamine amidotransferase of anthranilate synthase
D3Z18_RS03645	COG0133	tryptophan synthase activity
D3Z18_RS03660	COG1776	CheC inhibitor of MCP methylation
D3Z18_RS03660	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
D3Z18_RS03675	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
D3Z18_RS03680	COG0745	RESPONSE REGULATOR receiver
D3Z18_RS03690	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
D3Z18_RS03705	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
D3Z18_RS03710	COG1981	membrane
D3Z18_RS03715	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3Z18_RS03725	COG1538	Outer membrane efflux protein
D3Z18_RS03735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3Z18_RS03750	COG0828	Belongs to the bacterial ribosomal protein bS21 family
D3Z18_RS03765	COG0754	glutathionylspermidine amidase activity
D3Z18_RS03770	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
D3Z18_RS03790	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3Z18_RS03795	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
D3Z18_RS03800	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
D3Z18_RS03820	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
D3Z18_RS03835	COG1160	GTP binding
D3Z18_RS03870	COG0579	oxidoreductase
D3Z18_RS03875	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
D3Z18_RS03930	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
D3Z18_RS03950	COG1053	succinate dehydrogenase
D3Z18_RS03955	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D3Z18_RS03965	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D3Z18_RS04000	COG2353	YceI-like domain
D3Z18_RS04030	COG0488	(ABC) transporter
D3Z18_RS04045	COG1739	Uncharacterized protein family UPF0029
D3Z18_RS04085	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
D3Z18_RS04090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
D3Z18_RS04105	COG1028	Short-chain dehydrogenase reductase Sdr
D3Z18_RS04115	COG1053	succinate dehydrogenase
D3Z18_RS04120	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
D3Z18_RS04125	COG2048	Heterodisulfide reductase, subunit B
D3Z18_RS04130	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
D3Z18_RS04140	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
D3Z18_RS04170	COG0227	Belongs to the bacterial ribosomal protein bL28 family
D3Z18_RS04175	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
D3Z18_RS04205	COG2121	Domain of unknown function (DUF374)
D3Z18_RS04220	COG0195	Participates in both transcription termination and antitermination
D3Z18_RS04230	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D3Z18_RS04235	COG0612	Peptidase, M16
D3Z18_RS04240	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
D3Z18_RS04245	COG2346	COG2346, Truncated hemoglobins
D3Z18_RS04260	COG0765	amino acid transport
D3Z18_RS04290	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
D3Z18_RS04295	COG0267	Belongs to the bacterial ribosomal protein bL33 family
D3Z18_RS04310	COG0250	Participates in transcription elongation, termination and antitermination
D3Z18_RS04315	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
D3Z18_RS04320	COG0081	regulation of translation
D3Z18_RS04330	COG0222	ribosome binding
D3Z18_RS04350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3Z18_RS04360	COG2721	sulfolactate sulfo-lyase activity
D3Z18_RS04365	COG2271	Major facilitator Superfamily
D3Z18_RS04370	COG1028	Short-chain dehydrogenase reductase Sdr
D3Z18_RS04375	COG0738	Major facilitator superfamily
D3Z18_RS04385	COG3254	rhamnose metabolic process
D3Z18_RS04390	COG1012	belongs to the aldehyde dehydrogenase family
D3Z18_RS04400	COG0049	tRNA binding
D3Z18_RS04735	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
D3Z18_RS04740	COG0004	ammonium transporteR
D3Z18_RS04750	COG0673	inositol 2-dehydrogenase activity
D3Z18_RS04765	COG0424	maF-like protein
D3Z18_RS04775	COG0542	response to heat
D3Z18_RS04780	COG1937	Protein conserved in bacteria
D3Z18_RS04785	COG0793	Belongs to the peptidase S41A family
D3Z18_RS04795	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
D3Z18_RS04800	COG0047	phosphoribosylformylglycinamidine synthase activity
D3Z18_RS04810	COG0204	Acyl-transferase
D3Z18_RS04825	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
D3Z18_RS04845	COG1677	Flagellar hook-basal body complex protein FliE
D3Z18_RS04850	COG1558	bacterial-type flagellum-dependent cell motility
D3Z18_RS04855	COG1815	bacterial-type flagellum-dependent cell motility
D3Z18_RS04875	COG0039	L-malate dehydrogenase activity
D3Z18_RS04885	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
D3Z18_RS04895	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
D3Z18_RS04895	COG0674	pyruvate-flavodoxin oxidoreductase activity
D3Z18_RS04900	COG1013	pyruvate-flavodoxin oxidoreductase activity
D3Z18_RS04920	COG0142	geranyltranstransferase activity
D3Z18_RS04925	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
D3Z18_RS04940	COG0181	hydroxymethylbilane synthase activity
D3Z18_RS04945	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
D3Z18_RS04955	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
D3Z18_RS04975	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
D3Z18_RS05005	COG1289	transmembrane transporter activity
D3Z18_RS05010	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
D3Z18_RS05015	COG0492	ferredoxin-NADP+ reductase activity
D3Z18_RS05030	COG0305	Participates in initiation and elongation during chromosome replication
D3Z18_RS05075	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3Z18_RS05075	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3Z18_RS05080	COG1610	YqeY-like protein
D3Z18_RS05085	COG0028	Belongs to the TPP enzyme family
D3Z18_RS05090	COG0440	acetolactate synthase activity
D3Z18_RS05105	COG0805	protein transport
D3Z18_RS05115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3Z18_RS05120	COG0494	nUDIX hydrolase
D3Z18_RS05125	COG0527	aspartate kinase activity
D3Z18_RS05140	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
D3Z18_RS05145	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
D3Z18_RS05160	COG0196	riboflavin kinase activity
D3Z18_RS05165	COG2890	protein-(glutamine-N5) methyltransferase activity
D3Z18_RS05180	COG2860	membrane
D3Z18_RS05190	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
D3Z18_RS05195	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3Z18_RS05200	COG0191	fructose-bisphosphate aldolase activity
D3Z18_RS05220	COG0733	neurotransmitter:sodium symporter activity
D3Z18_RS05225	COG2258	MOSC domain
D3Z18_RS05240	COG1473	amidohydrolase
D3Z18_RS05245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
D3Z18_RS05250	COG1136	(ABC) transporter
D3Z18_RS05250	COG0577	efflux transmembrane transporter activity
D3Z18_RS05255	COG1538	Outer membrane efflux protein
D3Z18_RS05270	COG1696	Membrane protein involved in D-alanine export
D3Z18_RS05275	COG1528	Iron-storage protein
D3Z18_RS05280	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
D3Z18_RS05285	COG0573	inorganic phosphate transmembrane transporter activity
D3Z18_RS05290	COG0581	inorganic phosphate transmembrane transporter activity
D3Z18_RS05305	COG0534	Mate efflux family protein
D3Z18_RS05320	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
D3Z18_RS05330	COG0298	carbon dioxide binding
D3Z18_RS05335	COG0409	Hydrogenase expression formation protein
D3Z18_RS05340	COG0309	Hydrogenase expression formation protein (HypE)
D3Z18_RS05345	COG0375	protein maturation
D3Z18_RS05360	COG0557	exoribonuclease II activity
D3Z18_RS05375	COG0758	DNA mediated transformation
D3Z18_RS05395	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
D3Z18_RS05405	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
D3Z18_RS05415	COG0497	DNA recombination
D3Z18_RS05425	COG0084	hydrolase, TatD family'
D3Z18_RS05430	COG1388	LysM domain
D3Z18_RS05430	COG0791	NLP P60 protein
D3Z18_RS05435	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
D3Z18_RS05500	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
D3Z18_RS05525	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
D3Z18_RS05530	COG0802	atpase or kinase
D3Z18_RS05535	COG1137	ATPase activity
D3Z18_RS05540	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
D3Z18_RS05545	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
D3Z18_RS05575	COG0556	nucleotide-excision repair
D3Z18_RS05595	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
D3Z18_RS05605	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
D3Z18_RS05615	COG0280	phosphate acetyltransferase
D3Z18_RS05645	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
D3Z18_RS05650	COG0849	cell division
D3Z18_RS05655	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
D3Z18_RS05660	COG4786	Flagellar basal body rod
D3Z18_RS05665	COG4786	Flagellar basal body rod
D3Z18_RS05670	COG0174	glutamine synthetase
D3Z18_RS05680	COG0826	peptidase U32
D3Z18_RS05685	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
D3Z18_RS05700	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
D3Z18_RS05710	COG1519	Transferase
D3Z18_RS05710	COG0220	tRNA (guanine-N7-)-methyltransferase activity
D3Z18_RS05715	COG0564	pseudouridine synthase activity
D3Z18_RS05720	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
D3Z18_RS05725	COG0228	four-way junction DNA binding
D3Z18_RS05730	COG1837	Belongs to the UPF0109 family
D3Z18_RS05755	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
D3Z18_RS05760	COG1393	Belongs to the ArsC family
D3Z18_RS05770	COG0587	DNA-directed DNA polymerase activity
D3Z18_RS05775	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
D3Z18_RS05790	COG2890	protein-(glutamine-N5) methyltransferase activity
D3Z18_RS05795	COG0501	Belongs to the peptidase M48B family
D3Z18_RS05805	COG0521	Mo-molybdopterin cofactor biosynthetic process
D3Z18_RS05830	COG1178	ABC-type Fe3 transport system permease component
D3Z18_RS05840	COG3842	ATPase activity
D3Z18_RS05920	COG0675	Transposase, IS605 OrfB family
D3Z18_RS05930	COG4771	TonB-dependent receptor
D3Z18_RS05935	COG1420	regulation of RNA biosynthetic process
D3Z18_RS05945	COG0443	Heat shock 70 kDa protein
D3Z18_RS05965	COG0436	Aminotransferase
D3Z18_RS05970	COG1045	serine acetyltransferase
D3Z18_RS05975	COG1166	arginine decarboxylase activity
D3Z18_RS05990	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
D3Z18_RS05995	COG0163	prenyltransferase activity
D3Z18_RS06005	COG1464	Belongs to the NlpA lipoprotein family
D3Z18_RS06010	COG1464	Belongs to the NlpA lipoprotein family
D3Z18_RS06015	COG1464	Belongs to the NlpA lipoprotein family
D3Z18_RS06025	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D3Z18_RS06040	COG0210	DNA helicase
D3Z18_RS06050	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
D3Z18_RS06055	COG0243	molybdopterin cofactor binding
D3Z18_RS06060	COG0437	4 iron, 4 sulfur cluster binding
D3Z18_RS06065	COG0348	domain, Protein
D3Z18_RS06070	COG3043	anaerobic respiration
D3Z18_RS06100	COG0617	tRNA 3'-terminal CCA addition
D3Z18_RS06105	COG0788	formyltetrahydrofolate deformylase activity
D3Z18_RS06110	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
D3Z18_RS06120	COG0642	Histidine kinase
D3Z18_RS06130	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
D3Z18_RS06145	COG1181	Belongs to the D-alanine--D-alanine ligase family
D3Z18_RS06150	COG0632	four-way junction helicase activity
D3Z18_RS06160	COG0728	peptidoglycan biosynthetic process
D3Z18_RS06165	COG0215	cysteine-tRNA ligase activity
D3Z18_RS06170	COG1132	(ABC) transporter
D3Z18_RS06175	COG0167	dihydroorotate dehydrogenase activity
D3Z18_RS06180	COG0612	Peptidase, M16
D3Z18_RS06185	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
D3Z18_RS06190	COG1028	Short-chain dehydrogenase reductase Sdr
D3Z18_RS06205	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
D3Z18_RS06210	COG1663	tetraacyldisaccharide 4'-kinase activity
D3Z18_RS06215	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
D3Z18_RS06220	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
D3Z18_RS06235	COG1338	Plays a role in the flagellum-specific transport system
D3Z18_RS06240	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
D3Z18_RS06270	COG0101	tRNA pseudouridine synthase activity
D3Z18_RS06275	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
D3Z18_RS06295	COG1757	Na H antiporter
D3Z18_RS06300	COG4221	oxidoreductase activity
D3Z18_RS06310	COG1049	propionate catabolic process, 2-methylcitrate cycle
D3Z18_RS06315	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
D3Z18_RS06325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3Z18_RS06325	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3Z18_RS06335	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
D3Z18_RS06360	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
D3Z18_RS06365	COG1408	metallophosphoesterase
D3Z18_RS06370	COG0688	phosphatidylethanolamine metabolic process
D3Z18_RS06415	COG0681	Belongs to the peptidase S26 family
D3Z18_RS06420	COG0303	'Molybdopterin
D3Z18_RS06435	COG0512	Glutamine amidotransferase of anthranilate synthase
D3Z18_RS06435	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
D3Z18_RS06440	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
D3Z18_RS06445	COG0582	viral genome integration into host DNA
D3Z18_RS06450	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
D3Z18_RS06455	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
D3Z18_RS06505	COG3258	Cytochrome c
D3Z18_RS06530	COG2404	hydrolase activity, acting on ester bonds
D3Z18_RS06535	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
D3Z18_RS06545	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
D3Z18_RS06550	COG1674	ftsk spoiiie
D3Z18_RS06550	COG1196	nuclear chromosome segregation
D3Z18_RS06555	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3Z18_RS06570	COG0488	(ABC) transporter
D3Z18_RS06575	COG5002	protein histidine kinase activity
D3Z18_RS06580	COG0745	RESPONSE REGULATOR receiver
D3Z18_RS06585	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
D3Z18_RS06595	COG1185	polyribonucleotide nucleotidyltransferase activity
D3Z18_RS06595	COG0539	negative regulation of cytoplasmic translation
D3Z18_RS06600	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
D3Z18_RS06605	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
D3Z18_RS06610	COG0072	phenylalanine-tRNA ligase activity
D3Z18_RS06610	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
D3Z18_RS06615	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
D3Z18_RS06620	COG0537	adenosine 5'-monophosphoramidase activity
D3Z18_RS06635	COG0765	amino acid transport
D3Z18_RS06645	COG1115	amino acid carrier protein
D3Z18_RS06650	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
D3Z18_RS06655	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
D3Z18_RS06680	COG1999	signal sequence binding
D3Z18_RS06685	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
D3Z18_RS06690	COG0776	regulation of translation
D3Z18_RS06710	COG1966	Carbon starvation protein
D3Z18_RS06715	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
D3Z18_RS06720	COG0765	amino acid transport
D3Z18_RS06725	COG0765	amino acid transport
D3Z18_RS06730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3Z18_RS06735	COG1126	abc transporter atp-binding protein
D3Z18_RS06740	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
D3Z18_RS06745	COG2201	protein-glutamate methylesterase activity
D3Z18_RS06770	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
D3Z18_RS06775	COG0012	GTP binding
D3Z18_RS06785	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
D3Z18_RS06790	COG5016	pyruvate
D3Z18_RS06790	COG0511	ligase activity, forming carbon-carbon bonds
D3Z18_RS06795	COG0733	neurotransmitter:sodium symporter activity
D3Z18_RS06800	COG0733	neurotransmitter:sodium symporter activity
D3Z18_RS06865	COG0765	amino acid transport
D3Z18_RS06875	COG0653	protein targeting
D3Z18_RS06880	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
D3Z18_RS06890	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
D3Z18_RS06905	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
D3Z18_RS06920	COG0840	transmembrane signaling receptor activity
D3Z18_RS06930	COG0138	bifunctional purine biosynthesis protein purh
D3Z18_RS06935	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
D3Z18_RS06945	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
D3Z18_RS06955	COG0706	membrane insertase activity
D3Z18_RS06970	COG0230	Belongs to the bacterial ribosomal protein bL34 family
D3Z18_RS06985	COG0824	Thioesterase
D3Z18_RS07015	COG0500	methyltransferase
D3Z18_RS07035	COG2195	Cleaves the N-terminal amino acid of tripeptides
D3Z18_RS07040	COG0477	Major facilitator Superfamily
D3Z18_RS07045	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
D3Z18_RS07055	COG3022	response to hydroperoxide
D3Z18_RS07060	COG1473	amidohydrolase
D3Z18_RS07065	COG2807	transmembrane transport
D3Z18_RS07070	COG2807	transmembrane transport
D3Z18_RS07090	COG0247	lactate metabolic process
D3Z18_RS07090	COG2181	nitrate reductase activity
D3Z18_RS07095	COG0635	Involved in the biosynthesis of porphyrin-containing compound
D3Z18_RS07105	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
D3Z18_RS07110	COG0113	porphobilinogen synthase activity
D3Z18_RS07115	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
D3Z18_RS07120	COG0357	Ribosomal RNA small subunit methyltransferase G
D3Z18_RS07130	COG2855	membrane
D3Z18_RS07135	COG0583	DNA-binding transcription factor activity
D3Z18_RS07140	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
D3Z18_RS07160	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3Z18_RS07165	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3Z18_RS07255	COG1333	cytochrome c biogenesis protein
D3Z18_RS07255	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
D3Z18_RS07305	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
D3Z18_RS07325	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
D3Z18_RS07340	COG0481	GTPase activity
D3Z18_RS07365	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
D3Z18_RS07375	COG0439	Biotin carboxylase
D3Z18_RS07380	COG0772	Belongs to the SEDS family
D3Z18_RS07385	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
D3Z18_RS07405	COG0352	thiamine-phosphate diphosphorylase activity
D3Z18_RS07410	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
D3Z18_RS07415	COG2022	thiamine diphosphate biosynthetic process
D3Z18_RS07430	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
D3Z18_RS07440	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
D3Z18_RS07450	COG1193	negative regulation of DNA recombination
D3Z18_RS07480	COG0516	GMP reductase activity
D3Z18_RS07480	COG0517	IMP dehydrogenase activity
D3Z18_RS07500	COG1546	Belongs to the CinA family
D3Z18_RS07500	COG1058	Belongs to the CinA family
D3Z18_RS07505	COG0456	acetyltransferase
D3Z18_RS07510	COG0778	Nitroreductase
D3Z18_RS07515	COG0778	Nitroreductase
D3Z18_RS07525	COG0750	zinc metalloprotease
D3Z18_RS07530	COG2990	Protein conserved in bacteria
D3Z18_RS07540	COG0629	single-stranded DNA binding
D3Z18_RS07545	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
D3Z18_RS07550	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
D3Z18_RS07560	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
D3Z18_RS07565	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
D3Z18_RS07620	COG0739	heme binding
D3Z18_RS07625	COG0285	dihydrofolate synthase activity
D3Z18_RS07640	COG0495	leucyl-tRNA aminoacylation
D3Z18_RS07645	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3Z18_RS07650	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
D3Z18_RS07655	COG1862	Preprotein translocase
D3Z18_RS07660	COG0815	Transfers the fatty acyl group on membrane lipoproteins
D3Z18_RS07665	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
D3Z18_RS07670	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
D3Z18_RS07690	COG0210	DNA helicase
D3Z18_RS07725	COG0542	response to heat
D3Z18_RS07730	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
D3Z18_RS07740	COG2095	MarC family integral membrane protein
D3Z18_RS07745	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
D3Z18_RS07750	COG2833	Protein of unknown function (DUF455)
D3Z18_RS07755	COG1183	phosphatidylcholine synthase activity
D3Z18_RS07765	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
D3Z18_RS07775	COG0745	RESPONSE REGULATOR receiver
D3Z18_RS07785	COG1086	Polysaccharide biosynthesis protein
D3Z18_RS07790	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D3Z18_RS07795	COG0110	maltose O-acetyltransferase activity
D3Z18_RS07800	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
D3Z18_RS07805	COG0438	transferase activity, transferring glycosyl groups
D3Z18_RS07815	COG0438	transferase activity, transferring glycosyl groups
D3Z18_RS07820	COG1215	transferase activity, transferring glycosyl groups
D3Z18_RS07825	COG0438	transferase activity, transferring glycosyl groups
D3Z18_RS07830	COG1132	(ABC) transporter
D3Z18_RS07835	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
D3Z18_RS07845	COG0859	PFAM glycosyl transferase family 9
D3Z18_RS07850	COG1560	Kdo2-lipid A biosynthetic process
D3Z18_RS07870	COG1216	Glycosyl transferase, family 2
D3Z18_RS07870	COG1442	glycosyl transferase family 8
D3Z18_RS07875	COG1216	Glycosyl transferase, family 2
D3Z18_RS07915	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
D3Z18_RS07930	COG2217	Heavy metal translocating P-type atpase
D3Z18_RS07935	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
D3Z18_RS07940	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
D3Z18_RS07950	COG2217	Heavy metal translocating P-type atpase
D3Z18_RS07970	COG3610	response to peptide
D3Z18_RS07980	COG0039	L-malate dehydrogenase activity
D3Z18_RS07985	COG0586	Pfam SNARE associated Golgi protein
D3Z18_RS08000	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
D3Z18_RS08005	COG0217	transcriptional regulatory protein
D3Z18_RS08020	COG0018	arginyl-trna synthetase
D3Z18_RS08025	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
D3Z18_RS08030	COG0194	GDP metabolic process
D3Z18_RS08040	COG1684	flagellar biosynthetic protein fliR
D3Z18_RS08055	COG0052	Belongs to the universal ribosomal protein uS2 family
D3Z18_RS08060	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
D3Z18_RS08070	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
D3Z18_RS08075	COG0723	plastoquinol--plastocyanin reductase activity
D3Z18_RS08080	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
D3Z18_RS08085	COG0445	tRNA wobble uridine modification
D3Z18_RS08120	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
D3Z18_RS08155	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
D3Z18_RS08165	COG0356	it plays a direct role in the translocation of protons across the membrane
D3Z18_RS08170	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
D3Z18_RS08175	COG0552	protein localization to endoplasmic reticulum
D3Z18_RS08205	COG1295	ribonuclease BN
D3Z18_RS08210	COG0277	FAD linked oxidase domain protein
D3Z18_RS08220	COG0739	heme binding
D3Z18_RS08230	COG1496	oxidoreductase activity
D3Z18_RS08245	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
D3Z18_RS08255	COG0642	Histidine kinase
D3Z18_RS08260	COG0745	RESPONSE REGULATOR receiver
D3Z18_RS08280	COG0642	Histidine kinase
D3Z18_RS08285	COG0745	RESPONSE REGULATOR receiver
D3Z18_RS08290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
D3Z18_RS08295	COG0484	heat shock protein binding
D3Z18_RS08300	COG0789	Transcriptional regulator
D3Z18_RS08305	COG0475	glutathione-regulated potassium exporter activity
D3Z18_RS08305	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
D3Z18_RS08315	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
D3Z18_RS08320	COG0751	glycine-tRNA ligase activity
D3Z18_RS08325	COG0739	heme binding
D3Z18_RS08335	COG0248	Ppx GppA phosphatase
D3Z18_RS08355	COG2814	Major facilitator Superfamily
D3Z18_RS08370	COG0731	radical SAM domain protein
D3Z18_RS08390	COG0519	Catalyzes the synthesis of GMP from XMP
D3Z18_RS08390	COG0518	GMP synthase (glutamine-hydrolyzing) activity
D3Z18_RS08415	COG1185	polyribonucleotide nucleotidyltransferase activity
D3Z18_RS08430	COG2814	Major facilitator Superfamily
D3Z18_RS08435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
D3Z18_RS08440	COG4773	Receptor
D3Z18_RS08445	COG0484	heat shock protein binding
D3Z18_RS08450	COG0745	RESPONSE REGULATOR receiver
D3Z18_RS08455	COG0642	Histidine kinase
D3Z18_RS08460	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
D3Z18_RS08465	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
D3Z18_RS08470	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
D3Z18_RS08475	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
D3Z18_RS08480	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D3Z18_RS08485	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
D3Z18_RS08485	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
D3Z18_RS08490	COG0860	N-Acetylmuramoyl-L-alanine amidase
D3Z18_RS08505	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
D3Z18_RS08510	COG1758	RNA polymerase activity
D3Z18_RS08515	COG0528	UMP kinase activity
D3Z18_RS08530	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
D3Z18_RS08545	COG0564	pseudouridine synthase activity
D3Z18_RS08550	COG0772	Belongs to the SEDS family
D3Z18_RS08565	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
D3Z18_RS08570	COG0569	domain protein
D3Z18_RS08575	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
D3Z18_RS08580	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
D3Z18_RS08585	COG0280	phosphate acetyltransferase
D3Z18_RS08585	COG0281	malic enzyme
D3Z18_RS08600	COG0439	Biotin carboxylase
D3Z18_RS08605	COG0511	ligase activity, forming carbon-carbon bonds
D3Z18_RS08615	COG1086	Polysaccharide biosynthesis protein
D3Z18_RS08620	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D3Z18_RS08625	COG4310	Domain of unknown function (DUF2172)
D3Z18_RS08655	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
D3Z18_RS08695	COG1083	cytidylyl-transferase
D3Z18_RS08700	COG3980	spore coat polysaccharide biosynthesis protein
D3Z18_RS08715	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
D3Z18_RS08720	COG0107	imidazoleglycerol-phosphate synthase activity
D3Z18_RS08735	COG2089	acid synthase
D3Z18_RS08745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3Z18_RS08750	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
D3Z18_RS08780	COG2089	acid synthase
D3Z18_RS08785	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
D3Z18_RS08790	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
D3Z18_RS08800	COG1083	cytidylyl-transferase
D3Z18_RS08805	COG1028	Short-chain dehydrogenase reductase Sdr
D3Z18_RS08835	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
D3Z18_RS08860	COG2165	general secretion pathway protein
D3Z18_RS08865	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
D3Z18_RS08875	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
D3Z18_RS08880	COG0575	Belongs to the CDS family
D3Z18_RS08890	COG1293	RNA-binding protein homologous to eukaryotic snRNP
D3Z18_RS08900	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
D3Z18_RS08905	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
D3Z18_RS08910	COG4605	iron ion homeostasis
D3Z18_RS08915	COG4604	ABC transporter, ATP-binding protein
D3Z18_RS08920	COG4607	ABC-type enterochelin transport system periplasmic component
D3Z18_RS08935	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
D3Z18_RS08940	COG3005	denitrification pathway
D3Z18_RS08990	COG0628	permease
D3Z18_RS08995	COG0114	fumarate hydratase activity
D3Z18_RS09005	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
D3Z18_RS09015	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
D3Z18_RS09020	COG2252	PERMEase
D3Z18_RS09030	COG2853	Lipoprotein
D3Z18_RS09045	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
D3Z18_RS09050	COG2814	Major facilitator Superfamily
D3Z18_RS09065	COG3276	selenocysteine insertion sequence binding
D3Z18_RS09095	COG0753	catalase activity
D3Z18_RS09105	COG2964	Protein conserved in bacteria
D3Z18_RS09110	COG0251	oxidation-reduction process
D3Z18_RS09115	COG3069	C4-dicarboxylate transmembrane transporter activity
D3Z18_RS09135	COG1918	ferrous iron import across plasma membrane
D3Z18_RS09145	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
D3Z18_RS09150	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
D3Z18_RS09165	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
D3Z18_RS09190	COG1580	Controls the rotational direction of flagella during chemotaxis
D3Z18_RS09205	COG2124	cytochrome p450
D3Z18_RS09225	COG0529	Catalyzes the synthesis of activated sulfate
D3Z18_RS09230	COG1213	nucleotidyl transferase
D3Z18_RS09235	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
D3Z18_RS09240	COG3848	Pyruvate phosphate dikinase
D3Z18_RS09240	COG0574	Belongs to the PEP-utilizing enzyme family
D3Z18_RS09245	COG2226	methyltransferase
D3Z18_RS09295	COG1028	Short-chain dehydrogenase reductase Sdr
D3Z18_RS09300	COG0318	PFAM AMP-dependent synthetase and ligase
D3Z18_RS09315	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
D3Z18_RS09330	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3Z18_RS09335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
D3Z18_RS09380	COG0517	IMP dehydrogenase activity
D3Z18_RS09380	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
D3Z18_RS09425	COG0037	tRNA processing
D3Z18_RS09430	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
D3Z18_RS09440	COG0585	pseudouridine synthase activity
D3Z18_RS09445	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
D3Z18_RS09470	COG3951	Flagellar rod assembly protein muramidase FlgJ
D3Z18_RS09495	COG0730	response to heat
D3Z18_RS09625	COG4397	Mu-like prophage major head subunit gpT
D3Z18_RS09670	COG4383	Mu-like prophage protein gp29