locus-tag	class	description
E8N02_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
E8N02_RS00010	COG0592	DNA-directed DNA polymerase activity
E8N02_RS00015	COG0187	DNA topoisomerase II activity
E8N02_RS00030	COG2056	Na+-H+ antiporter family
E8N02_RS00035	COG0070	glutamate synthase
E8N02_RS00035	COG0069	glutamate synthase activity
E8N02_RS00035	COG0067	glutamate synthase
E8N02_RS00045	COG0493	'glutamate synthase
E8N02_RS00050	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
E8N02_RS00060	COG1592	Rubrerythrin
E8N02_RS00065	COG0129	dihydroxy-acid dehydratase activity
E8N02_RS00080	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
E8N02_RS00095	COG0840	transmembrane signaling receptor activity
E8N02_RS00100	COG1858	cytochrome C peroxidase
E8N02_RS00105	COG0179	Fumarylacetoacetate (FAA) hydrolase
E8N02_RS00110	COG0564	pseudouridine synthase activity
E8N02_RS00115	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
E8N02_RS00120	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E8N02_RS00135	COG0504	CTP synthase activity
E8N02_RS00145	COG0252	asparaginase activity
E8N02_RS00195	COG2814	Major facilitator Superfamily
E8N02_RS00230	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
E8N02_RS00260	COG0471	metal ion transport
E8N02_RS00270	COG0471	metal ion transport
E8N02_RS00280	COG0482	sulfurtransferase activity
E8N02_RS00310	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E8N02_RS00310	COG1776	CheC inhibitor of MCP methylation
E8N02_RS00315	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E8N02_RS00320	COG1191	sigma factor activity
E8N02_RS00330	COG0455	bacterial-type flagellum organization
E8N02_RS00335	COG1419	protein localization to endoplasmic reticulum
E8N02_RS00340	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
E8N02_RS00345	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
E8N02_RS00350	COG0402	S-adenosylhomocysteine deaminase activity
E8N02_RS00355	COG0616	signal peptide processing
E8N02_RS00380	COG1139	Iron-sulfur cluster binding protein
E8N02_RS00385	COG0247	lactate metabolic process
E8N02_RS00400	COG3021	interspecies interaction between organisms
E8N02_RS00415	COG1271	oxidase subunit
E8N02_RS00420	COG1294	oxidase, subunit
E8N02_RS00425	COG1794	racemase activity, acting on amino acids and derivatives
E8N02_RS00435	COG1027	Aspartate ammonia-lyase
E8N02_RS00440	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E8N02_RS00470	COG0261	This protein binds to 23S rRNA in the presence of protein L20
E8N02_RS00475	COG0211	Belongs to the bacterial ribosomal protein bL27 family
E8N02_RS00495	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
E8N02_RS00495	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
E8N02_RS00500	COG1192	Involved in chromosome partitioning
E8N02_RS00505	COG1475	DNA binding
E8N02_RS00520	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
E8N02_RS00535	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
E8N02_RS00540	COG0355	proton-transporting ATP synthase activity, rotational mechanism
E8N02_RS00545	COG0811	peptide transport
E8N02_RS00550	COG0848	biopolymer transport protein
E8N02_RS00565	COG2885	chlorophyll binding
E8N02_RS00575	COG1047	Peptidyl-prolyl cis-trans
E8N02_RS00580	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
E8N02_RS00585	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
E8N02_RS00590	COG0037	tRNA processing
E8N02_RS00910	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
E8N02_RS00920	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
E8N02_RS00925	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
E8N02_RS00930	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
E8N02_RS00940	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
E8N02_RS00965	COG0083	homoserine kinase activity
E8N02_RS00985	COG0779	Required for maturation of 30S ribosomal subunits
E8N02_RS00990	COG1401	restriction endodeoxyribonuclease activity
E8N02_RS01000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
E8N02_RS01005	COG1121	(ABC) transporter
E8N02_RS01015	COG0840	transmembrane signaling receptor activity
E8N02_RS01025	COG0492	ferredoxin-NADP+ reductase activity
E8N02_RS01030	COG3118	belongs to the thioredoxin family
E8N02_RS01035	COG0792	nuclease activity
E8N02_RS01040	COG0460	homoserine dehydrogenase
E8N02_RS01045	COG0436	Aminotransferase
E8N02_RS01060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
E8N02_RS01065	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
E8N02_RS01070	COG0254	rRNA binding
E8N02_RS01075	COG1385	rRNA (uridine-N3-)-methyltransferase activity
E8N02_RS01095	COG0602	queuosine metabolic process
E8N02_RS01100	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
E8N02_RS01125	COG1971	Probably functions as a manganese efflux pump
E8N02_RS01140	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
E8N02_RS01165	COG1840	ABC-type Fe3 transport system, periplasmic component
E8N02_RS01180	COG1629	transport
E8N02_RS01180	COG4206	TonB-dependent receptor
E8N02_RS01185	COG0811	peptide transport
E8N02_RS01190	COG0848	biopolymer transport protein
E8N02_RS01200	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
E8N02_RS01205	COG1253	flavin adenine dinucleotide binding
E8N02_RS01215	COG2824	Alkylphosphonate utilization operon protein PhnA
E8N02_RS01220	COG0861	Integral membrane protein TerC family
E8N02_RS01225	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
E8N02_RS01230	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
E8N02_RS01230	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
E8N02_RS01240	COG0606	chelatase, subunit chli
E8N02_RS01245	COG0242	peptide deformylase activity
E8N02_RS01255	COG0544	peptidyl-prolyl cis-trans isomerase activity
E8N02_RS01265	COG1157	protein secretion by the type III secretion system
E8N02_RS01270	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
E8N02_RS01275	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
E8N02_RS01280	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
E8N02_RS01280	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
E8N02_RS01305	COG2851	Citrate transporter
E8N02_RS01310	COG1297	OPT oligopeptide transporter protein
E8N02_RS01315	COG1968	undecaprenyl-diphosphatase activity
E8N02_RS01325	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
E8N02_RS01375	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
E8N02_RS01380	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
E8N02_RS01385	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
E8N02_RS01400	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
E8N02_RS01420	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
E8N02_RS01425	COG0670	Belongs to the BI1 family
E8N02_RS01430	COG0288	reversible hydration of carbon dioxide
E8N02_RS01435	COG0668	transmembrane transport
E8N02_RS01460	COG0291	Belongs to the bacterial ribosomal protein bL35 family
E8N02_RS01465	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
E8N02_RS01485	COG0477	Major facilitator Superfamily
E8N02_RS01495	COG0315	cyclic pyranopterin monophosphate synthase activity
E8N02_RS01500	COG2921	Belongs to the UPF0250 family
E8N02_RS01510	COG0708	Exodeoxyribonuclease III
E8N02_RS01515	COG2194	sulfuric ester hydrolase activity
E8N02_RS01520	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
E8N02_RS01530	COG0418	dihydroorotase activity
E8N02_RS01540	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
E8N02_RS01560	COG0330	HflC and HflK could
E8N02_RS01570	COG1942	4-Oxalocrotonate Tautomerase
E8N02_RS01575	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
E8N02_RS01580	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
E8N02_RS01585	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
E8N02_RS01595	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
E8N02_RS01600	COG1077	Cell shape determining protein MreB Mrl
E8N02_RS01610	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E8N02_RS01630	COG0835	chemotaxis
E8N02_RS01635	COG0784	Response regulator, receiver
E8N02_RS01635	COG0643	Histidine kinase
E8N02_RS01635	COG2198	Histidine kinase
E8N02_RS01640	COG0784	Response regulator, receiver
E8N02_RS01640	COG0835	chemotaxis
E8N02_RS01655	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
E8N02_RS01660	COG0515	serine threonine protein kinase
E8N02_RS01660	COG2815	serine threonine protein kinase
E8N02_RS01695	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
E8N02_RS01715	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
E8N02_RS01735	COG4106	trans-aconitate 2-methyltransferase activity
E8N02_RS01750	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
E8N02_RS01755	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
E8N02_RS01760	COG2076	Multidrug Resistance protein
E8N02_RS01785	COG0019	diaminopimelate decarboxylase activity
E8N02_RS01800	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E8N02_RS01810	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E8N02_RS01820	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
E8N02_RS01835	COG2226	methyltransferase
E8N02_RS01840	COG1570	exodeoxyribonuclease VII activity
E8N02_RS01845	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
E8N02_RS01850	COG0251	oxidation-reduction process
E8N02_RS01865	COG0333	Belongs to the bacterial ribosomal protein bL32 family
E8N02_RS01885	COG0450	alkyl hydroperoxide reductase
E8N02_RS01890	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E8N02_RS01895	COG1360	Flagellar Motor Protein
E8N02_RS01900	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
E8N02_RS01920	COG1238	metal cluster binding
E8N02_RS01925	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
E8N02_RS01930	COG0730	response to heat
E8N02_RS01945	COG0512	Glutamine amidotransferase of anthranilate synthase
E8N02_RS01945	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E8N02_RS01955	COG0133	tryptophan synthase activity
E8N02_RS01970	COG1776	CheC inhibitor of MCP methylation
E8N02_RS01970	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
E8N02_RS01985	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
E8N02_RS01990	COG0745	RESPONSE REGULATOR receiver
E8N02_RS02010	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
E8N02_RS02015	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
E8N02_RS02025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E8N02_RS02035	COG1538	Outer membrane efflux protein
E8N02_RS02045	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8N02_RS02060	COG0828	Belongs to the bacterial ribosomal protein bS21 family
E8N02_RS02070	COG0754	glutathionylspermidine amidase activity
E8N02_RS02075	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
E8N02_RS02095	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E8N02_RS02100	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
E8N02_RS02105	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
E8N02_RS02125	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
E8N02_RS02155	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
E8N02_RS02175	COG0579	oxidoreductase
E8N02_RS02180	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
E8N02_RS02215	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
E8N02_RS02235	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
E8N02_RS02255	COG1053	succinate dehydrogenase
E8N02_RS02260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E8N02_RS02270	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E8N02_RS02335	COG0488	(ABC) transporter
E8N02_RS02350	COG1739	Uncharacterized protein family UPF0029
E8N02_RS02390	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
E8N02_RS02405	COG1028	Short-chain dehydrogenase reductase Sdr
E8N02_RS02415	COG1053	succinate dehydrogenase
E8N02_RS02420	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
E8N02_RS02425	COG2048	Heterodisulfide reductase, subunit B
E8N02_RS02430	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
E8N02_RS02435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
E8N02_RS02440	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
E8N02_RS02470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
E8N02_RS02475	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
E8N02_RS02485	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
E8N02_RS02505	COG2121	Domain of unknown function (DUF374)
E8N02_RS02520	COG0195	Participates in both transcription termination and antitermination
E8N02_RS02530	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E8N02_RS02535	COG0612	Peptidase, M16
E8N02_RS02540	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
E8N02_RS02545	COG2346	COG2346, Truncated hemoglobins
E8N02_RS02560	COG0765	amino acid transport
E8N02_RS02590	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
E8N02_RS02595	COG0267	Belongs to the bacterial ribosomal protein bL33 family
E8N02_RS02610	COG0250	Participates in transcription elongation, termination and antitermination
E8N02_RS02615	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
E8N02_RS02620	COG0081	regulation of translation
E8N02_RS02630	COG0222	ribosome binding
E8N02_RS02645	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
E8N02_RS02650	COG0049	tRNA binding
E8N02_RS02695	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
E8N02_RS02700	COG0004	ammonium transporteR
E8N02_RS02710	COG0673	inositol 2-dehydrogenase activity
E8N02_RS02725	COG0424	maF-like protein
E8N02_RS02735	COG0542	response to heat
E8N02_RS02740	COG1937	Protein conserved in bacteria
E8N02_RS02745	COG0793	Belongs to the peptidase S41A family
E8N02_RS02750	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
E8N02_RS02755	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
E8N02_RS02760	COG0047	phosphoribosylformylglycinamidine synthase activity
E8N02_RS02770	COG0204	Acyl-transferase
E8N02_RS02785	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
E8N02_RS02805	COG1677	Flagellar hook-basal body complex protein FliE
E8N02_RS02810	COG1558	bacterial-type flagellum-dependent cell motility
E8N02_RS02815	COG1815	bacterial-type flagellum-dependent cell motility
E8N02_RS02835	COG0039	L-malate dehydrogenase activity
E8N02_RS02845	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
E8N02_RS02855	COG0674	pyruvate-flavodoxin oxidoreductase activity
E8N02_RS02855	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
E8N02_RS02860	COG1013	pyruvate-flavodoxin oxidoreductase activity
E8N02_RS02880	COG0142	geranyltranstransferase activity
E8N02_RS02885	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
E8N02_RS02900	COG0181	hydroxymethylbilane synthase activity
E8N02_RS02905	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
E8N02_RS02915	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
E8N02_RS02935	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
E8N02_RS02965	COG1289	transmembrane transporter activity
E8N02_RS02970	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
E8N02_RS02975	COG0492	ferredoxin-NADP+ reductase activity
E8N02_RS02990	COG0305	Participates in initiation and elongation during chromosome replication
E8N02_RS03040	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E8N02_RS03040	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E8N02_RS03045	COG1610	YqeY-like protein
E8N02_RS03050	COG0028	Belongs to the TPP enzyme family
E8N02_RS03055	COG0440	acetolactate synthase activity
E8N02_RS03070	COG0805	protein transport
E8N02_RS03080	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E8N02_RS03085	COG0494	nUDIX hydrolase
E8N02_RS03090	COG0527	aspartate kinase activity
E8N02_RS03105	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
E8N02_RS03110	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
E8N02_RS03125	COG0196	riboflavin kinase activity
E8N02_RS03130	COG2890	protein-(glutamine-N5) methyltransferase activity
E8N02_RS03145	COG2860	membrane
E8N02_RS03155	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
E8N02_RS03160	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
E8N02_RS03165	COG0191	fructose-bisphosphate aldolase activity
E8N02_RS03185	COG0733	neurotransmitter:sodium symporter activity
E8N02_RS03190	COG2258	MOSC domain
E8N02_RS03205	COG1473	amidohydrolase
E8N02_RS03210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
E8N02_RS03215	COG0577	efflux transmembrane transporter activity
E8N02_RS03215	COG1136	(ABC) transporter
E8N02_RS03220	COG1538	Outer membrane efflux protein
E8N02_RS03235	COG1696	Membrane protein involved in D-alanine export
E8N02_RS03240	COG1528	Iron-storage protein
E8N02_RS03245	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
E8N02_RS03250	COG0573	inorganic phosphate transmembrane transporter activity
E8N02_RS03255	COG0581	inorganic phosphate transmembrane transporter activity
E8N02_RS03270	COG0534	Mate efflux family protein
E8N02_RS03285	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
E8N02_RS03295	COG0298	carbon dioxide binding
E8N02_RS03300	COG0409	Hydrogenase expression formation protein
E8N02_RS03305	COG0309	Hydrogenase expression formation protein (HypE)
E8N02_RS03310	COG0375	protein maturation
E8N02_RS03315	COG2189	Belongs to the N(4) N(6)-methyltransferase family
E8N02_RS03320	COG3421	Type III restriction
E8N02_RS03330	COG0557	exoribonuclease II activity
E8N02_RS03335	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
E8N02_RS03345	COG0758	DNA mediated transformation
E8N02_RS03365	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
E8N02_RS03375	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
E8N02_RS03385	COG0497	DNA recombination
E8N02_RS03395	COG0084	hydrolase, TatD family'
E8N02_RS03400	COG0791	NLP P60 protein
E8N02_RS03400	COG1388	LysM domain
E8N02_RS03405	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
E8N02_RS03445	COG3104	oligopeptide transport
E8N02_RS03465	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
E8N02_RS03485	COG0137	argininosuccinate synthase activity
E8N02_RS03490	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
E8N02_RS03495	COG0802	atpase or kinase
E8N02_RS03500	COG1137	ATPase activity
E8N02_RS03505	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
E8N02_RS03510	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
E8N02_RS03525	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
E8N02_RS03535	COG2205	protein histidine kinase activity
E8N02_RS03560	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
E8N02_RS03570	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
E8N02_RS03580	COG0280	phosphate acetyltransferase
E8N02_RS03585	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
E8N02_RS03615	COG0849	cell division
E8N02_RS03620	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
E8N02_RS03625	COG4786	Flagellar basal body rod
E8N02_RS03630	COG4786	Flagellar basal body rod
E8N02_RS03635	COG0174	glutamine synthetase
E8N02_RS03650	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
E8N02_RS03660	COG0752	glycyl-tRNA synthetase alpha subunit
E8N02_RS03665	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
E8N02_RS03675	COG1519	Transferase
E8N02_RS03675	COG0220	tRNA (guanine-N7-)-methyltransferase activity
E8N02_RS03680	COG0564	pseudouridine synthase activity
E8N02_RS03685	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
E8N02_RS03690	COG0228	four-way junction DNA binding
E8N02_RS03695	COG1837	Belongs to the UPF0109 family
E8N02_RS03700	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
E8N02_RS03720	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
E8N02_RS03725	COG1393	Belongs to the ArsC family
E8N02_RS03735	COG0587	DNA-directed DNA polymerase activity
E8N02_RS03740	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
E8N02_RS03755	COG2890	protein-(glutamine-N5) methyltransferase activity
E8N02_RS03760	COG0501	Belongs to the peptidase M48B family
E8N02_RS03770	COG0521	Mo-molybdopterin cofactor biosynthetic process
E8N02_RS03775	COG0598	Magnesium transport protein CorA
E8N02_RS03795	COG1178	ABC-type Fe3 transport system permease component
E8N02_RS03805	COG3842	ATPase activity
E8N02_RS03880	COG0675	Transposase, IS605 OrfB family
E8N02_RS03890	COG4771	TonB-dependent receptor
E8N02_RS03895	COG1420	regulation of RNA biosynthetic process
E8N02_RS03900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
E8N02_RS03920	COG0436	Aminotransferase
E8N02_RS03925	COG1045	serine acetyltransferase
E8N02_RS03930	COG1166	arginine decarboxylase activity
E8N02_RS03945	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
E8N02_RS03950	COG0163	prenyltransferase activity
E8N02_RS03960	COG1464	Belongs to the NlpA lipoprotein family
E8N02_RS03965	COG1464	Belongs to the NlpA lipoprotein family
E8N02_RS03970	COG1464	Belongs to the NlpA lipoprotein family
E8N02_RS03975	COG2011	ABC-type metal ion transport system permease component
E8N02_RS03980	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E8N02_RS03995	COG0210	DNA helicase
E8N02_RS04005	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
E8N02_RS04015	COG0437	4 iron, 4 sulfur cluster binding
E8N02_RS04020	COG0348	domain, Protein
E8N02_RS04025	COG3043	anaerobic respiration
E8N02_RS04060	COG0788	formyltetrahydrofolate deformylase activity
E8N02_RS04065	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
E8N02_RS04075	COG0642	Histidine kinase
E8N02_RS04085	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
E8N02_RS04100	COG1181	Belongs to the D-alanine--D-alanine ligase family
E8N02_RS04105	COG0632	four-way junction helicase activity
E8N02_RS04115	COG0728	peptidoglycan biosynthetic process
E8N02_RS04120	COG0215	cysteine-tRNA ligase activity
E8N02_RS04125	COG1132	(ABC) transporter
E8N02_RS04130	COG0167	dihydroorotate dehydrogenase activity
E8N02_RS04135	COG0612	Peptidase, M16
E8N02_RS04140	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
E8N02_RS04145	COG1028	Short-chain dehydrogenase reductase Sdr
E8N02_RS04160	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
E8N02_RS04170	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
E8N02_RS04175	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
E8N02_RS04190	COG1338	Plays a role in the flagellum-specific transport system
E8N02_RS04195	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E8N02_RS04225	COG0101	tRNA pseudouridine synthase activity
E8N02_RS04230	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
E8N02_RS04250	COG1757	Na H antiporter
E8N02_RS04255	COG4221	oxidoreductase activity
E8N02_RS04265	COG1049	propionate catabolic process, 2-methylcitrate cycle
E8N02_RS04270	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
E8N02_RS04280	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E8N02_RS04280	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E8N02_RS04290	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
E8N02_RS04320	COG1408	metallophosphoesterase
E8N02_RS04325	COG0688	phosphatidylethanolamine metabolic process
E8N02_RS04370	COG0681	Belongs to the peptidase S26 family
E8N02_RS04375	COG0303	'Molybdopterin
E8N02_RS04390	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
E8N02_RS04390	COG0512	Glutamine amidotransferase of anthranilate synthase
E8N02_RS04395	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
E8N02_RS04400	COG0582	viral genome integration into host DNA
E8N02_RS04410	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
E8N02_RS04445	COG2404	hydrolase activity, acting on ester bonds
E8N02_RS04450	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
E8N02_RS04455	COG1959	2 iron, 2 sulfur cluster binding
E8N02_RS04460	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
E8N02_RS04465	COG1196	nuclear chromosome segregation
E8N02_RS04465	COG1674	ftsk spoiiie
E8N02_RS04470	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E8N02_RS04490	COG5002	protein histidine kinase activity
E8N02_RS04495	COG0745	RESPONSE REGULATOR receiver
E8N02_RS04500	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
E8N02_RS04510	COG1185	polyribonucleotide nucleotidyltransferase activity
E8N02_RS04510	COG0539	negative regulation of cytoplasmic translation
E8N02_RS04515	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
E8N02_RS04520	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
E8N02_RS04525	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
E8N02_RS04525	COG0072	phenylalanine-tRNA ligase activity
E8N02_RS04530	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
E8N02_RS04535	COG0537	adenosine 5'-monophosphoramidase activity
E8N02_RS04550	COG0765	amino acid transport
E8N02_RS04560	COG1115	amino acid carrier protein
E8N02_RS04570	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
E8N02_RS04595	COG1999	signal sequence binding
E8N02_RS04600	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
E8N02_RS04605	COG0776	regulation of translation
E8N02_RS04625	COG1966	Carbon starvation protein
E8N02_RS04630	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
E8N02_RS04635	COG0765	amino acid transport
E8N02_RS04640	COG0765	amino acid transport
E8N02_RS04645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E8N02_RS04650	COG1126	abc transporter atp-binding protein
E8N02_RS04655	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
E8N02_RS04660	COG2201	protein-glutamate methylesterase activity
E8N02_RS04685	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
E8N02_RS04690	COG0012	GTP binding
E8N02_RS04700	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
E8N02_RS04705	COG5016	pyruvate
E8N02_RS04705	COG0511	ligase activity, forming carbon-carbon bonds
E8N02_RS04710	COG0733	neurotransmitter:sodium symporter activity
E8N02_RS04715	COG0733	neurotransmitter:sodium symporter activity
E8N02_RS04780	COG0765	amino acid transport
E8N02_RS04790	COG0653	protein targeting
E8N02_RS04795	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
E8N02_RS04805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
E8N02_RS04820	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
E8N02_RS04840	COG0840	transmembrane signaling receptor activity
E8N02_RS04850	COG0138	bifunctional purine biosynthesis protein purh
E8N02_RS04855	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
E8N02_RS04865	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
E8N02_RS04875	COG0706	membrane insertase activity
E8N02_RS04890	COG0230	Belongs to the bacterial ribosomal protein bL34 family
E8N02_RS04965	COG2195	Cleaves the N-terminal amino acid of tripeptides
E8N02_RS04970	COG0477	Major facilitator Superfamily
E8N02_RS04975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
E8N02_RS04985	COG3022	response to hydroperoxide
E8N02_RS04990	COG1473	amidohydrolase
E8N02_RS04995	COG2807	transmembrane transport
E8N02_RS05010	COG2181	nitrate reductase activity
E8N02_RS05010	COG0247	lactate metabolic process
E8N02_RS05015	COG0635	Involved in the biosynthesis of porphyrin-containing compound
E8N02_RS05025	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
E8N02_RS05030	COG0113	porphobilinogen synthase activity
E8N02_RS05035	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
E8N02_RS05040	COG0357	Ribosomal RNA small subunit methyltransferase G
E8N02_RS05050	COG2855	membrane
E8N02_RS05055	COG0583	DNA-binding transcription factor activity
E8N02_RS05060	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
E8N02_RS05080	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E8N02_RS05085	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
E8N02_RS05440	COG3501	Rhs element vgr protein
E8N02_RS05510	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
E8N02_RS05510	COG1333	cytochrome c biogenesis protein
E8N02_RS05535	COG0683	leucine binding
E8N02_RS05560	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
E8N02_RS05565	COG2204	response regulator
E8N02_RS05580	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
E8N02_RS05595	COG0481	GTPase activity
E8N02_RS05620	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
E8N02_RS05630	COG0439	Biotin carboxylase
E8N02_RS05635	COG0772	Belongs to the SEDS family
E8N02_RS05640	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
E8N02_RS05660	COG0352	thiamine-phosphate diphosphorylase activity
E8N02_RS05665	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E8N02_RS05670	COG2022	thiamine diphosphate biosynthetic process
E8N02_RS05685	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
E8N02_RS05705	COG1193	negative regulation of DNA recombination
E8N02_RS05735	COG0516	GMP reductase activity
E8N02_RS05735	COG0517	IMP dehydrogenase activity
E8N02_RS05755	COG1546	Belongs to the CinA family
E8N02_RS05755	COG1058	Belongs to the CinA family
E8N02_RS05765	COG0778	Nitroreductase
E8N02_RS05770	COG0778	Nitroreductase
E8N02_RS05780	COG0750	zinc metalloprotease
E8N02_RS05785	COG2990	Protein conserved in bacteria
E8N02_RS05795	COG0629	single-stranded DNA binding
E8N02_RS05800	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
E8N02_RS05805	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
E8N02_RS05815	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
E8N02_RS05820	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
E8N02_RS05865	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
E8N02_RS05875	COG0739	heme binding
E8N02_RS05880	COG0285	dihydrofolate synthase activity
E8N02_RS05900	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E8N02_RS05905	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
E8N02_RS05910	COG1862	Preprotein translocase
E8N02_RS05915	COG0815	Transfers the fatty acyl group on membrane lipoproteins
E8N02_RS05920	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
E8N02_RS05925	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
E8N02_RS05930	COG0540	Belongs to the ATCase OTCase family
E8N02_RS05945	COG0210	DNA helicase
E8N02_RS05980	COG0542	response to heat
E8N02_RS05985	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
E8N02_RS05995	COG2095	MarC family integral membrane protein
E8N02_RS06000	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
E8N02_RS06005	COG2833	Protein of unknown function (DUF455)
E8N02_RS06010	COG1183	phosphatidylcholine synthase activity
E8N02_RS06020	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
E8N02_RS06030	COG0745	RESPONSE REGULATOR receiver
E8N02_RS06040	COG1086	Polysaccharide biosynthesis protein
E8N02_RS06045	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E8N02_RS06050	COG0110	maltose O-acetyltransferase activity
E8N02_RS06055	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
E8N02_RS06060	COG0438	transferase activity, transferring glycosyl groups
E8N02_RS06070	COG0438	transferase activity, transferring glycosyl groups
E8N02_RS06075	COG1215	transferase activity, transferring glycosyl groups
E8N02_RS06080	COG0438	transferase activity, transferring glycosyl groups
E8N02_RS06085	COG1132	(ABC) transporter
E8N02_RS06090	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
E8N02_RS06100	COG0859	PFAM glycosyl transferase family 9
E8N02_RS06105	COG1560	Kdo2-lipid A biosynthetic process
E8N02_RS06110	COG0463	Glycosyl transferase, family 2
E8N02_RS06115	COG1442	glycosyl transferase family 8
E8N02_RS06115	COG1216	Glycosyl transferase, family 2
E8N02_RS06125	COG1216	Glycosyl transferase, family 2
E8N02_RS06125	COG1442	glycosyl transferase family 8
E8N02_RS06135	COG2089	acid synthase
E8N02_RS06155	COG0110	maltose O-acetyltransferase activity
E8N02_RS06160	COG1216	Glycosyl transferase, family 2
E8N02_RS06185	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E8N02_RS06200	COG2217	Heavy metal translocating P-type atpase
E8N02_RS06205	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
E8N02_RS06210	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
E8N02_RS06225	COG2217	Heavy metal translocating P-type atpase
E8N02_RS06245	COG3610	response to peptide
E8N02_RS06255	COG0039	L-malate dehydrogenase activity
E8N02_RS06260	COG0586	Pfam SNARE associated Golgi protein
E8N02_RS06275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
E8N02_RS06280	COG0217	transcriptional regulatory protein
E8N02_RS06295	COG0018	arginyl-trna synthetase
E8N02_RS06300	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
E8N02_RS06305	COG0194	GDP metabolic process
E8N02_RS06325	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
E8N02_RS06330	COG0052	Belongs to the universal ribosomal protein uS2 family
E8N02_RS06335	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
E8N02_RS06345	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
E8N02_RS06350	COG0723	plastoquinol--plastocyanin reductase activity
E8N02_RS06355	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
E8N02_RS06380	COG1301	dicarboxylic acid transport
E8N02_RS06395	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
E8N02_RS06430	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
E8N02_RS06445	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
E8N02_RS06450	COG0552	protein localization to endoplasmic reticulum
E8N02_RS06465	COG1418	mRNA catabolic process
E8N02_RS06480	COG1295	ribonuclease BN
E8N02_RS06485	COG0277	FAD linked oxidase domain protein
E8N02_RS06495	COG0739	heme binding
E8N02_RS06520	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
E8N02_RS06525	COG0459	protein refolding
E8N02_RS06530	COG0642	Histidine kinase
E8N02_RS06535	COG0745	RESPONSE REGULATOR receiver
E8N02_RS06555	COG0642	Histidine kinase
E8N02_RS06560	COG0745	RESPONSE REGULATOR receiver
E8N02_RS06565	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
E8N02_RS06570	COG0484	heat shock protein binding
E8N02_RS06575	COG0789	Transcriptional regulator
E8N02_RS06580	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
E8N02_RS06580	COG0475	glutathione-regulated potassium exporter activity
E8N02_RS06590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
E8N02_RS06595	COG0751	glycine-tRNA ligase activity
E8N02_RS06600	COG0739	heme binding
E8N02_RS06610	COG0248	Ppx GppA phosphatase
E8N02_RS06630	COG2814	Major facilitator Superfamily
E8N02_RS06645	COG0731	radical SAM domain protein
E8N02_RS06665	COG0519	Catalyzes the synthesis of GMP from XMP
E8N02_RS06665	COG0518	GMP synthase (glutamine-hydrolyzing) activity
E8N02_RS06690	COG1185	polyribonucleotide nucleotidyltransferase activity
E8N02_RS06710	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
E8N02_RS06715	COG4773	Receptor
E8N02_RS06720	COG0484	heat shock protein binding
E8N02_RS06725	COG0745	RESPONSE REGULATOR receiver
E8N02_RS06730	COG0642	Histidine kinase
E8N02_RS06735	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
E8N02_RS06740	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
E8N02_RS06745	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
E8N02_RS06750	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
E8N02_RS06755	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E8N02_RS06780	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
E8N02_RS06785	COG1758	RNA polymerase activity
E8N02_RS06790	COG0528	UMP kinase activity
E8N02_RS06805	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
E8N02_RS06820	COG0564	pseudouridine synthase activity
E8N02_RS06825	COG0772	Belongs to the SEDS family
E8N02_RS06840	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
E8N02_RS06845	COG0569	domain protein
E8N02_RS06850	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
E8N02_RS06855	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
E8N02_RS06860	COG0281	malic enzyme
E8N02_RS06860	COG0280	phosphate acetyltransferase
E8N02_RS06875	COG0439	Biotin carboxylase
E8N02_RS06880	COG0511	ligase activity, forming carbon-carbon bonds
E8N02_RS06890	COG1086	Polysaccharide biosynthesis protein
E8N02_RS06895	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E8N02_RS06935	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
E8N02_RS06985	COG1083	cytidylyl-transferase
E8N02_RS06990	COG3980	spore coat polysaccharide biosynthesis protein
E8N02_RS06995	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
E8N02_RS07000	COG0107	imidazoleglycerol-phosphate synthase activity
E8N02_RS07015	COG2089	acid synthase
E8N02_RS07025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E8N02_RS07030	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
E8N02_RS07045	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
E8N02_RS07065	COG2089	acid synthase
E8N02_RS07070	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
E8N02_RS07075	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
E8N02_RS07085	COG1083	cytidylyl-transferase
E8N02_RS07090	COG1028	Short-chain dehydrogenase reductase Sdr
E8N02_RS07115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E8N02_RS07120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
E8N02_RS07140	COG2165	general secretion pathway protein
E8N02_RS07145	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
E8N02_RS07160	COG0575	Belongs to the CDS family
E8N02_RS07170	COG1293	RNA-binding protein homologous to eukaryotic snRNP
E8N02_RS07180	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
E8N02_RS07185	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E8N02_RS07190	COG4605	iron ion homeostasis
E8N02_RS07195	COG4604	ABC transporter, ATP-binding protein
E8N02_RS07200	COG4607	ABC-type enterochelin transport system periplasmic component
E8N02_RS07215	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
E8N02_RS07220	COG3005	denitrification pathway
E8N02_RS07250	COG0628	permease
E8N02_RS07255	COG0114	fumarate hydratase activity
E8N02_RS07265	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
E8N02_RS07275	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
E8N02_RS07280	COG2252	PERMEase
E8N02_RS07290	COG2853	Lipoprotein
E8N02_RS07310	COG2814	Major facilitator Superfamily
E8N02_RS07325	COG3276	selenocysteine insertion sequence binding
E8N02_RS07355	COG0753	catalase activity
E8N02_RS07365	COG2964	Protein conserved in bacteria
E8N02_RS07370	COG0251	oxidation-reduction process
E8N02_RS07415	COG1918	ferrous iron import across plasma membrane
E8N02_RS07420	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
E8N02_RS07425	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
E8N02_RS07430	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
E8N02_RS07445	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
E8N02_RS07470	COG1580	Controls the rotational direction of flagella during chemotaxis
E8N02_RS07485	COG2124	cytochrome p450
E8N02_RS07505	COG0529	Catalyzes the synthesis of activated sulfate
E8N02_RS07510	COG1213	nucleotidyl transferase
E8N02_RS07515	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
E8N02_RS07520	COG3848	Pyruvate phosphate dikinase
E8N02_RS07520	COG0574	Belongs to the PEP-utilizing enzyme family
E8N02_RS07525	COG2226	methyltransferase
E8N02_RS07550	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
E8N02_RS07570	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
E8N02_RS07600	COG1216	Glycosyl transferase, family 2
E8N02_RS07615	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
E8N02_RS07620	COG1216	Glycosyl transferase, family 2
E8N02_RS07625	COG0562	UDP-galactopyranose mutase
E8N02_RS07630	COG1442	glycosyl transferase family 8
E8N02_RS07630	COG1216	Glycosyl transferase, family 2
E8N02_RS07645	COG0517	IMP dehydrogenase activity
E8N02_RS07645	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
E8N02_RS07700	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
E8N02_RS07715	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
E8N02_RS07735	COG1706	bacterial-type flagellum-dependent cell motility
E8N02_RS07740	COG3951	Flagellar rod assembly protein muramidase FlgJ
E8N02_RS07765	COG0730	response to heat
E8N02_RS07770	COG1459	type II secretion system
E8N02_RS07805	COG0546	phosphoglycolate phosphatase activity
E8N02_RS07815	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
E8N02_RS07820	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
E8N02_RS07825	COG0210	DNA helicase
E8N02_RS07830	COG2887	Belongs to the helicase family. UvrD subfamily
E8N02_RS07875	COG0745	RESPONSE REGULATOR receiver
E8N02_RS07890	COG0505	Belongs to the CarA family
E8N02_RS07910	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
E8N02_RS07925	COG0425	Belongs to the sulfur carrier protein TusA family
E8N02_RS07930	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
E8N02_RS07960	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
E8N02_RS07970	COG0437	4 iron, 4 sulfur cluster binding
E8N02_RS08005	COG0314	molybdopterin synthase activity
E8N02_RS08010	COG0303	'Molybdopterin
E8N02_RS08015	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
E8N02_RS08040	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
E8N02_RS08055	COG2992	FlgJ-related protein
E8N02_RS08065	COG0783	Belongs to the Dps family
E8N02_RS08070	COG0166	Belongs to the GPI family
E8N02_RS08080	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
E8N02_RS08085	COG3839	Belongs to the ABC transporter superfamily
E8N02_RS08090	COG4662	Binding-protein-dependent transport system inner membrane component
E8N02_RS08095	COG2998	abc-type tungstate transport system, permease component
E8N02_RS08100	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
E8N02_RS08105	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
E8N02_RS08110	COG1984	allophanate hydrolase subunit 2
E8N02_RS08120	COG2249	NAD(P)H dehydrogenase (quinone) activity
E8N02_RS08125	COG1733	regulation of RNA biosynthetic process
E8N02_RS08135	COG1064	alcohol dehydrogenase
E8N02_RS08150	COG0732	type I restriction modification DNA specificity domain
E8N02_RS08180	COG2814	Major facilitator Superfamily
E8N02_RS08185	COG2910	NAD(P)H-binding
E8N02_RS08190	COG1733	regulation of RNA biosynthetic process
E8N02_RS08200	COG0640	Transcriptional regulator
E8N02_RS08210	COG0840	transmembrane signaling receptor activity
E8N02_RS08225	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E8N02_RS08230	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
E8N02_RS08240	COG0839	Belongs to the complex I subunit 6 family
E8N02_RS08250	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
E8N02_RS08275	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E8N02_RS08285	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
E8N02_RS08300	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
E8N02_RS08315	COG0277	FAD linked oxidase domain protein
E8N02_RS08325	COG4615	Cyclic peptide transporter
E8N02_RS08345	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
E8N02_RS08350	COG0257	Belongs to the bacterial ribosomal protein bL36 family
E8N02_RS08360	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
E8N02_RS08370	COG0202	RNA polymerase activity
E8N02_RS08375	COG0203	ribosomal protein L17
E8N02_RS08390	COG0131	Imidazoleglycerol-phosphate dehydratase
E8N02_RS08390	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
E8N02_RS08415	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
E8N02_RS08415	COG0140	phosphoribosyl-ATP diphosphatase activity
E8N02_RS08420	COG2171	N-acyltransferase activity
E8N02_RS08425	COG0489	protein tyrosine kinase activity
E8N02_RS08430	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
E8N02_RS08430	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
E8N02_RS08440	COG2046	Belongs to the sulfate adenylyltransferase family
E8N02_RS08445	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
E8N02_RS08450	COG0268	Binds directly to 16S ribosomal RNA
E8N02_RS08460	COG0748	coenzyme F420 binding
E8N02_RS08465	COG4771	TonB-dependent receptor
E8N02_RS08470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
E8N02_RS08475	COG1120	ATPase activity
E8N02_RS08480	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
E8N02_RS08495	COG1194	a g-specific adenine glycosylase
E8N02_RS08525	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E8N02_RS08525	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
E8N02_RS08535	COG1760	l-serine dehydratase
E8N02_RS08540	COG0814	amino acid
E8N02_RS08555	COG0811	peptide transport
E8N02_RS08560	COG0848	biopolymer transport protein
E8N02_RS08585	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
E8N02_RS08590	COG0571	ribonuclease III activity
E8N02_RS08595	COG0328	RNA-DNA hybrid ribonuclease activity
E8N02_RS08605	COG0358	DNA primase activity
E8N02_RS08620	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
E8N02_RS08625	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
E8N02_RS08640	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
E8N02_RS08645	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
E8N02_RS08650	COG1127	ABC transporter
E8N02_RS08660	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
E8N02_RS08660	COG3218	ABC-type transport auxiliary lipoprotein component
E8N02_RS08670	COG0024	Methionine aminopeptidase
E8N02_RS08675	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
E8N02_RS08680	COG0791	NLP P60 protein
E8N02_RS08690	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
E8N02_RS08700	COG0672	)-iron permease
E8N02_RS08725	COG1136	(ABC) transporter
E8N02_RS08775	COG1793	dna ligase
E8N02_RS08790	COG0148	phosphopyruvate hydratase activity
E8N02_RS08795	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
E8N02_RS08800	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
E8N02_RS08805	COG1987	bacterial-type flagellum assembly
E8N02_RS08820	COG1218	3'(2'),5'-bisphosphate nucleotidase
E8N02_RS08825	COG0372	Belongs to the citrate synthase family
E8N02_RS08835	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
E8N02_RS08840	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
E8N02_RS08850	COG0201	protein transport
E8N02_RS08855	COG0200	Binds to the 23S rRNA
E8N02_RS08860	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
E8N02_RS08865	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
E8N02_RS08870	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
E8N02_RS08875	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
E8N02_RS08880	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
E8N02_RS08885	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
E8N02_RS08890	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
E8N02_RS08895	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
E8N02_RS08900	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
E8N02_RS08905	COG0255	Belongs to the universal ribosomal protein uL29 family
E8N02_RS08910	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
E8N02_RS08915	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
E8N02_RS08925	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
E8N02_RS08935	COG0089	rRNA binding
E8N02_RS08945	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
E8N02_RS08950	COG0051	transcription antitermination factor activity, RNA binding
E8N02_RS08955	COG1187	pseudouridine synthase activity
E8N02_RS08960	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
E8N02_RS09015	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
E8N02_RS09040	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
E8N02_RS09050	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
E8N02_RS09060	COG1749	Flagellar hook protein flgE
E8N02_RS09065	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group