locus-tag	class	description
H0232_RS00010	COG0592	DNA-directed DNA polymerase activity
H0232_RS00015	COG0187	DNA topoisomerase II activity
H0232_RS00030	COG2056	Na+-H+ antiporter family
H0232_RS00035	COG0067	glutamate synthase
H0232_RS00035	COG0069	glutamate synthase activity
H0232_RS00035	COG0070	glutamate synthase
H0232_RS00040	COG0493	'glutamate synthase
H0232_RS00045	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
H0232_RS00055	COG1592	Rubrerythrin
H0232_RS00060	COG0129	dihydroxy-acid dehydratase activity
H0232_RS00075	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
H0232_RS00090	COG0840	transmembrane signaling receptor activity
H0232_RS00095	COG1858	cytochrome C peroxidase
H0232_RS00100	COG0179	Fumarylacetoacetate (FAA) hydrolase
H0232_RS00105	COG0564	pseudouridine synthase activity
H0232_RS00110	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
H0232_RS00115	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0232_RS00130	COG0504	CTP synthase activity
H0232_RS00140	COG0252	asparaginase activity
H0232_RS00170	COG0484	heat shock protein binding
H0232_RS00185	COG1333	cytochrome c biogenesis protein
H0232_RS00185	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H0232_RS00190	COG0405	Gamma-glutamyltransferase
H0232_RS00195	COG2890	protein-(glutamine-N5) methyltransferase activity
H0232_RS00220	COG2814	Major facilitator Superfamily
H0232_RS00255	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
H0232_RS00290	COG1611	Belongs to the LOG family
H0232_RS00295	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H0232_RS00295	COG1776	CheC inhibitor of MCP methylation
H0232_RS00300	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H0232_RS00305	COG1191	sigma factor activity
H0232_RS00315	COG0455	bacterial-type flagellum organization
H0232_RS00320	COG1419	protein localization to endoplasmic reticulum
H0232_RS00325	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
H0232_RS00330	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
H0232_RS00335	COG0402	S-adenosylhomocysteine deaminase activity
H0232_RS00340	COG0616	signal peptide processing
H0232_RS00350	COG2703	oxygen carrier activity
H0232_RS00360	COG2703	oxygen carrier activity
H0232_RS00380	COG1139	Iron-sulfur cluster binding protein
H0232_RS00385	COG0247	lactate metabolic process
H0232_RS00400	COG3021	interspecies interaction between organisms
H0232_RS00415	COG1271	oxidase subunit
H0232_RS00420	COG1294	oxidase, subunit
H0232_RS00435	COG1794	racemase activity, acting on amino acids and derivatives
H0232_RS00440	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
H0232_RS00445	COG1027	Aspartate ammonia-lyase
H0232_RS00450	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H0232_RS00480	COG0261	This protein binds to 23S rRNA in the presence of protein L20
H0232_RS00485	COG0211	Belongs to the bacterial ribosomal protein bL27 family
H0232_RS00500	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
H0232_RS00505	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
H0232_RS00505	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
H0232_RS00510	COG1192	Involved in chromosome partitioning
H0232_RS00515	COG1475	DNA binding
H0232_RS00525	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
H0232_RS00530	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
H0232_RS00545	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
H0232_RS00550	COG0355	proton-transporting ATP synthase activity, rotational mechanism
H0232_RS00555	COG0811	peptide transport
H0232_RS00560	COG0848	biopolymer transport protein
H0232_RS00575	COG2885	chlorophyll binding
H0232_RS00585	COG1047	Peptidyl-prolyl cis-trans
H0232_RS00595	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
H0232_RS00600	COG0037	tRNA processing
H0232_RS00625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
H0232_RS00635	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
H0232_RS00640	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
H0232_RS00645	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
H0232_RS00655	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
H0232_RS00680	COG0083	homoserine kinase activity
H0232_RS00725	COG1108	ABC-type Mn2 Zn2 transport systems permease components
H0232_RS00730	COG1121	(ABC) transporter
H0232_RS00740	COG0840	transmembrane signaling receptor activity
H0232_RS00750	COG0492	ferredoxin-NADP+ reductase activity
H0232_RS00755	COG3118	belongs to the thioredoxin family
H0232_RS00760	COG0792	nuclease activity
H0232_RS00765	COG0460	homoserine dehydrogenase
H0232_RS00770	COG0436	Aminotransferase
H0232_RS00785	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
H0232_RS00790	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
H0232_RS00795	COG0254	rRNA binding
H0232_RS00800	COG1385	rRNA (uridine-N3-)-methyltransferase activity
H0232_RS00820	COG0602	queuosine metabolic process
H0232_RS00825	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
H0232_RS00845	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
H0232_RS00850	COG1971	Probably functions as a manganese efflux pump
H0232_RS00865	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
H0232_RS00885	COG1840	ABC-type Fe3 transport system, periplasmic component
H0232_RS00900	COG4206	TonB-dependent receptor
H0232_RS00900	COG1629	transport
H0232_RS00905	COG0811	peptide transport
H0232_RS00910	COG0848	biopolymer transport protein
H0232_RS00920	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
H0232_RS00925	COG1253	flavin adenine dinucleotide binding
H0232_RS00935	COG2824	Alkylphosphonate utilization operon protein PhnA
H0232_RS00940	COG0861	Integral membrane protein TerC family
H0232_RS00945	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
H0232_RS00950	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
H0232_RS00950	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
H0232_RS00960	COG0606	chelatase, subunit chli
H0232_RS00965	COG0242	peptide deformylase activity
H0232_RS00980	COG0302	gtp cyclohydrolase
H0232_RS00985	COG1157	protein secretion by the type III secretion system
H0232_RS00990	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
H0232_RS01000	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
H0232_RS01000	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
H0232_RS01025	COG2851	Citrate transporter
H0232_RS01030	COG1297	OPT oligopeptide transporter protein
H0232_RS01035	COG1968	undecaprenyl-diphosphatase activity
H0232_RS01045	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
H0232_RS01090	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
H0232_RS01095	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
H0232_RS01100	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
H0232_RS01105	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
H0232_RS01115	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
H0232_RS01135	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
H0232_RS01140	COG0670	Belongs to the BI1 family
H0232_RS01145	COG0288	reversible hydration of carbon dioxide
H0232_RS01150	COG0668	transmembrane transport
H0232_RS01175	COG0291	Belongs to the bacterial ribosomal protein bL35 family
H0232_RS01180	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
H0232_RS01185	COG0840	transmembrane signaling receptor activity
H0232_RS01185	COG3290	protein histidine kinase activity
H0232_RS01205	COG0477	Major facilitator Superfamily
H0232_RS01220	COG2921	Belongs to the UPF0250 family
H0232_RS01230	COG0708	Exodeoxyribonuclease III
H0232_RS01235	COG2194	sulfuric ester hydrolase activity
H0232_RS01240	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
H0232_RS01250	COG0418	dihydroorotase activity
H0232_RS01260	COG2226	methyltransferase
H0232_RS01265	COG0840	transmembrane signaling receptor activity
H0232_RS01270	COG0428	transporter
H0232_RS01275	COG0243	molybdopterin cofactor binding
H0232_RS01295	COG0330	HflC and HflK could
H0232_RS01305	COG1942	4-Oxalocrotonate Tautomerase
H0232_RS01310	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
H0232_RS01315	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
H0232_RS01325	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0232_RS01330	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
H0232_RS01335	COG1077	Cell shape determining protein MreB Mrl
H0232_RS01345	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H0232_RS01365	COG0835	chemotaxis
H0232_RS01370	COG0643	Histidine kinase
H0232_RS01370	COG0784	Response regulator, receiver
H0232_RS01370	COG2198	Histidine kinase
H0232_RS01375	COG0784	Response regulator, receiver
H0232_RS01375	COG0835	chemotaxis
H0232_RS01385	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
H0232_RS01390	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
H0232_RS01415	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
H0232_RS01430	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
H0232_RS01465	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
H0232_RS01470	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
H0232_RS01475	COG2076	Multidrug Resistance protein
H0232_RS01500	COG0019	diaminopimelate decarboxylase activity
H0232_RS01515	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
H0232_RS01525	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H0232_RS01560	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
H0232_RS01565	COG0251	oxidation-reduction process
H0232_RS01570	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H0232_RS01580	COG0333	Belongs to the bacterial ribosomal protein bL32 family
H0232_RS01600	COG0450	alkyl hydroperoxide reductase
H0232_RS01605	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H0232_RS01610	COG1360	Flagellar Motor Protein
H0232_RS01615	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
H0232_RS01625	COG0477	Major facilitator Superfamily
H0232_RS01635	COG1238	metal cluster binding
H0232_RS01640	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
H0232_RS01645	COG0730	response to heat
H0232_RS01660	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0232_RS01660	COG0512	Glutamine amidotransferase of anthranilate synthase
H0232_RS01670	COG0133	tryptophan synthase activity
H0232_RS01685	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
H0232_RS01685	COG1776	CheC inhibitor of MCP methylation
H0232_RS01700	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
H0232_RS01705	COG0745	RESPONSE REGULATOR receiver
H0232_RS01715	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
H0232_RS01730	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
H0232_RS01740	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0232_RS01750	COG1538	Outer membrane efflux protein
H0232_RS01760	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0232_RS01775	COG0828	Belongs to the bacterial ribosomal protein bS21 family
H0232_RS01785	COG0754	glutathionylspermidine amidase activity
H0232_RS01790	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
H0232_RS01810	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0232_RS01820	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
H0232_RS01835	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
H0232_RS01840	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
H0232_RS01855	COG1160	GTP binding
H0232_RS01860	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
H0232_RS01870	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
H0232_RS01890	COG0579	oxidoreductase
H0232_RS01895	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
H0232_RS01915	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
H0232_RS01950	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
H0232_RS01970	COG1053	succinate dehydrogenase
H0232_RS01975	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H0232_RS02020	COG2353	YceI-like domain
H0232_RS02050	COG0488	(ABC) transporter
H0232_RS02065	COG1739	Uncharacterized protein family UPF0029
H0232_RS02105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
H0232_RS02110	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
H0232_RS02115	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
H0232_RS02120	COG1028	Short-chain dehydrogenase reductase Sdr
H0232_RS02130	COG1053	succinate dehydrogenase
H0232_RS02135	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
H0232_RS02140	COG2048	Heterodisulfide reductase, subunit B
H0232_RS02145	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
H0232_RS02150	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
H0232_RS02155	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
H0232_RS02165	COG4771	TonB-dependent receptor
H0232_RS02170	COG0494	nUDIX hydrolase
H0232_RS02175	COG0840	transmembrane signaling receptor activity
H0232_RS02185	COG0227	Belongs to the bacterial ribosomal protein bL28 family
H0232_RS02190	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
H0232_RS02200	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
H0232_RS02220	COG2121	Domain of unknown function (DUF374)
H0232_RS02235	COG0195	Participates in both transcription termination and antitermination
H0232_RS02245	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H0232_RS02250	COG0612	Peptidase, M16
H0232_RS02255	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
H0232_RS02260	COG2346	COG2346, Truncated hemoglobins
H0232_RS02275	COG0765	amino acid transport
H0232_RS02305	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
H0232_RS02310	COG0267	Belongs to the bacterial ribosomal protein bL33 family
H0232_RS02325	COG0250	Participates in transcription elongation, termination and antitermination
H0232_RS02330	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
H0232_RS02335	COG0081	regulation of translation
H0232_RS02340	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
H0232_RS02345	COG0222	ribosome binding
H0232_RS02350	COG0085	RNA polymerase activity
H0232_RS02360	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
H0232_RS02365	COG0049	tRNA binding
H0232_RS02410	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
H0232_RS02415	COG0004	ammonium transporteR
H0232_RS02425	COG0673	inositol 2-dehydrogenase activity
H0232_RS02435	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
H0232_RS02440	COG0424	maF-like protein
H0232_RS02450	COG0542	response to heat
H0232_RS02455	COG1937	Protein conserved in bacteria
H0232_RS02460	COG0793	Belongs to the peptidase S41A family
H0232_RS02465	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
H0232_RS02470	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
H0232_RS02475	COG0047	phosphoribosylformylglycinamidine synthase activity
H0232_RS02485	COG0204	Acyl-transferase
H0232_RS02500	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
H0232_RS02520	COG1677	Flagellar hook-basal body complex protein FliE
H0232_RS02525	COG1558	bacterial-type flagellum-dependent cell motility
H0232_RS02530	COG1815	bacterial-type flagellum-dependent cell motility
H0232_RS02550	COG0039	L-malate dehydrogenase activity
H0232_RS02560	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
H0232_RS02570	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
H0232_RS02570	COG0674	pyruvate-flavodoxin oxidoreductase activity
H0232_RS02575	COG1013	pyruvate-flavodoxin oxidoreductase activity
H0232_RS02595	COG0142	geranyltranstransferase activity
H0232_RS02600	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
H0232_RS02605	COG0442	prolyl-tRNA aminoacylation
H0232_RS02615	COG0181	hydroxymethylbilane synthase activity
H0232_RS02620	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
H0232_RS02630	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
H0232_RS02650	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
H0232_RS02680	COG1289	transmembrane transporter activity
H0232_RS02685	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
H0232_RS02690	COG0492	ferredoxin-NADP+ reductase activity
H0232_RS02705	COG0305	Participates in initiation and elongation during chromosome replication
H0232_RS02765	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0232_RS02765	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0232_RS02770	COG1610	YqeY-like protein
H0232_RS02775	COG0028	Belongs to the TPP enzyme family
H0232_RS02780	COG0440	acetolactate synthase activity
H0232_RS02790	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
H0232_RS02795	COG0805	protein transport
H0232_RS02805	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0232_RS02810	COG0494	nUDIX hydrolase
H0232_RS02815	COG0527	aspartate kinase activity
H0232_RS02830	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
H0232_RS02835	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
H0232_RS02850	COG0196	riboflavin kinase activity
H0232_RS02855	COG2890	protein-(glutamine-N5) methyltransferase activity
H0232_RS02870	COG2860	membrane
H0232_RS02880	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
H0232_RS02885	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0232_RS02890	COG0191	fructose-bisphosphate aldolase activity
H0232_RS02910	COG0733	neurotransmitter:sodium symporter activity
H0232_RS02915	COG2258	MOSC domain
H0232_RS02930	COG1473	amidohydrolase
H0232_RS02935	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
H0232_RS02940	COG0577	efflux transmembrane transporter activity
H0232_RS02940	COG1136	(ABC) transporter
H0232_RS02945	COG1538	Outer membrane efflux protein
H0232_RS02960	COG1696	Membrane protein involved in D-alanine export
H0232_RS02965	COG1528	Iron-storage protein
H0232_RS02970	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
H0232_RS02975	COG0573	inorganic phosphate transmembrane transporter activity
H0232_RS02980	COG0581	inorganic phosphate transmembrane transporter activity
H0232_RS02995	COG0534	Mate efflux family protein
H0232_RS03010	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
H0232_RS03020	COG0298	carbon dioxide binding
H0232_RS03025	COG0409	Hydrogenase expression formation protein
H0232_RS03030	COG0309	Hydrogenase expression formation protein (HypE)
H0232_RS03035	COG0375	protein maturation
H0232_RS03050	COG0557	exoribonuclease II activity
H0232_RS03055	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
H0232_RS03065	COG0758	DNA mediated transformation
H0232_RS03080	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0232_RS03085	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
H0232_RS03090	COG0563	adenylate kinase activity
H0232_RS03095	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
H0232_RS03100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
H0232_RS03105	COG0497	DNA recombination
H0232_RS03115	COG0084	hydrolase, TatD family'
H0232_RS03120	COG1388	LysM domain
H0232_RS03120	COG0791	NLP P60 protein
H0232_RS03125	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
H0232_RS03145	COG0218	Necessary for normal cell division and for the maintenance of normal septation
H0232_RS03165	COG3104	oligopeptide transport
H0232_RS03170	COG3104	oligopeptide transport
H0232_RS03185	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
H0232_RS03190	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
H0232_RS03195	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
H0232_RS03200	COG0359	binds to the 23S rRNA
H0232_RS03205	COG0137	argininosuccinate synthase activity
H0232_RS03210	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
H0232_RS03215	COG0802	atpase or kinase
H0232_RS03220	COG1137	ATPase activity
H0232_RS03225	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
H0232_RS03230	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
H0232_RS03245	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H0232_RS03250	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
H0232_RS03265	COG0556	nucleotide-excision repair
H0232_RS03285	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
H0232_RS03295	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
H0232_RS03305	COG0280	phosphate acetyltransferase
H0232_RS03330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
H0232_RS03335	COG0849	cell division
H0232_RS03340	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
H0232_RS03345	COG4786	Flagellar basal body rod
H0232_RS03350	COG4786	Flagellar basal body rod
H0232_RS03355	COG0174	glutamine synthetase
H0232_RS03370	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
H0232_RS03380	COG0752	glycyl-tRNA synthetase alpha subunit
H0232_RS03385	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
H0232_RS03395	COG0220	tRNA (guanine-N7-)-methyltransferase activity
H0232_RS03395	COG1519	Transferase
H0232_RS03400	COG0564	pseudouridine synthase activity
H0232_RS03405	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
H0232_RS03410	COG0228	four-way junction DNA binding
H0232_RS03415	COG1837	Belongs to the UPF0109 family
H0232_RS03420	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
H0232_RS03425	COG0336	Belongs to the RNA methyltransferase TrmD family
H0232_RS03430	COG0335	large ribosomal subunit rRNA binding
H0232_RS03440	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
H0232_RS03445	COG1393	Belongs to the ArsC family
H0232_RS03455	COG0587	DNA-directed DNA polymerase activity
H0232_RS03460	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
H0232_RS03475	COG2890	protein-(glutamine-N5) methyltransferase activity
H0232_RS03480	COG0501	Belongs to the peptidase M48B family
H0232_RS03490	COG0521	Mo-molybdopterin cofactor biosynthetic process
H0232_RS03495	COG0598	Magnesium transport protein CorA
H0232_RS03525	COG3842	ATPase activity
H0232_RS03610	COG4771	TonB-dependent receptor
H0232_RS03615	COG1420	regulation of RNA biosynthetic process
H0232_RS03625	COG0443	Heat shock 70 kDa protein
H0232_RS03660	COG0436	Aminotransferase
H0232_RS03665	COG1045	serine acetyltransferase
H0232_RS03670	COG1166	arginine decarboxylase activity
H0232_RS03675	COG0124	histidyl-tRNA synthetase
H0232_RS03680	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
H0232_RS03685	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
H0232_RS03690	COG0163	prenyltransferase activity
H0232_RS03700	COG1464	Belongs to the NlpA lipoprotein family
H0232_RS03705	COG1464	Belongs to the NlpA lipoprotein family
H0232_RS03710	COG1464	Belongs to the NlpA lipoprotein family
H0232_RS03715	COG2011	ABC-type metal ion transport system permease component
H0232_RS03720	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0232_RS03735	COG0210	DNA helicase
H0232_RS03745	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
H0232_RS03755	COG0437	4 iron, 4 sulfur cluster binding
H0232_RS03760	COG0348	domain, Protein
H0232_RS03765	COG3043	anaerobic respiration
H0232_RS03800	COG0788	formyltetrahydrofolate deformylase activity
H0232_RS03805	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
H0232_RS03815	COG0642	Histidine kinase
H0232_RS03825	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
H0232_RS03840	COG1181	Belongs to the D-alanine--D-alanine ligase family
H0232_RS03845	COG0632	four-way junction helicase activity
H0232_RS03855	COG0728	peptidoglycan biosynthetic process
H0232_RS03860	COG0215	cysteine-tRNA ligase activity
H0232_RS03865	COG1132	(ABC) transporter
H0232_RS03870	COG0167	dihydroorotate dehydrogenase activity
H0232_RS03875	COG0612	Peptidase, M16
H0232_RS03885	COG1028	Short-chain dehydrogenase reductase Sdr
H0232_RS03900	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
H0232_RS03905	COG1663	tetraacyldisaccharide 4'-kinase activity
H0232_RS03910	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
H0232_RS03915	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
H0232_RS03930	COG1338	Plays a role in the flagellum-specific transport system
H0232_RS03965	COG0101	tRNA pseudouridine synthase activity
H0232_RS03970	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
H0232_RS03990	COG1757	Na H antiporter
H0232_RS03995	COG4221	oxidoreductase activity
H0232_RS04005	COG1049	propionate catabolic process, 2-methylcitrate cycle
H0232_RS04010	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
H0232_RS04020	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0232_RS04020	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0232_RS04030	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
H0232_RS04055	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0232_RS04060	COG1408	metallophosphoesterase
H0232_RS04065	COG0688	phosphatidylethanolamine metabolic process
H0232_RS04105	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
H0232_RS04110	COG0681	Belongs to the peptidase S26 family
H0232_RS04115	COG0303	'Molybdopterin
H0232_RS04130	COG0512	Glutamine amidotransferase of anthranilate synthase
H0232_RS04130	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
H0232_RS04135	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
H0232_RS04140	COG0582	viral genome integration into host DNA
H0232_RS04145	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
H0232_RS04150	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
H0232_RS04165	COG3258	Cytochrome c
H0232_RS04185	COG2404	hydrolase activity, acting on ester bonds
H0232_RS04190	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
H0232_RS04195	COG1959	2 iron, 2 sulfur cluster binding
H0232_RS04200	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
H0232_RS04205	COG1674	ftsk spoiiie
H0232_RS04205	COG1196	nuclear chromosome segregation
H0232_RS04210	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
H0232_RS04230	COG5002	protein histidine kinase activity
H0232_RS04235	COG0745	RESPONSE REGULATOR receiver
H0232_RS04240	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
H0232_RS04250	COG0539	negative regulation of cytoplasmic translation
H0232_RS04250	COG1185	polyribonucleotide nucleotidyltransferase activity
H0232_RS04265	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
H0232_RS04265	COG0072	phenylalanine-tRNA ligase activity
H0232_RS04270	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
H0232_RS04275	COG0537	adenosine 5'-monophosphoramidase activity
H0232_RS04290	COG0765	amino acid transport
H0232_RS04300	COG1115	amino acid carrier protein
H0232_RS04305	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
H0232_RS04310	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
H0232_RS04335	COG1999	signal sequence binding
H0232_RS04340	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
H0232_RS04345	COG0776	regulation of translation
H0232_RS04365	COG1966	Carbon starvation protein
H0232_RS04370	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
H0232_RS04375	COG0765	amino acid transport
H0232_RS04380	COG0765	amino acid transport
H0232_RS04385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0232_RS04390	COG1126	abc transporter atp-binding protein
H0232_RS04395	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
H0232_RS04400	COG2201	protein-glutamate methylesterase activity
H0232_RS04425	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
H0232_RS04430	COG0012	GTP binding
H0232_RS04440	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
H0232_RS04445	COG5016	pyruvate
H0232_RS04445	COG0511	ligase activity, forming carbon-carbon bonds
H0232_RS04450	COG0733	neurotransmitter:sodium symporter activity
H0232_RS04455	COG0733	neurotransmitter:sodium symporter activity
H0232_RS04550	COG0765	amino acid transport
H0232_RS04555	COG4591	ABC-type transport system involved in lipoprotein release permease component
H0232_RS04560	COG0653	protein targeting
H0232_RS04565	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
H0232_RS04575	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0232_RS04590	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
H0232_RS04605	COG0840	transmembrane signaling receptor activity
H0232_RS04610	COG0138	bifunctional purine biosynthesis protein purh
H0232_RS04615	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
H0232_RS04625	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
H0232_RS04635	COG0706	membrane insertase activity
H0232_RS04640	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
H0232_RS04650	COG0230	Belongs to the bacterial ribosomal protein bL34 family
H0232_RS04670	COG0824	Thioesterase
H0232_RS04700	COG0500	methyltransferase
H0232_RS04720	COG2195	Cleaves the N-terminal amino acid of tripeptides
H0232_RS04725	COG0477	Major facilitator Superfamily
H0232_RS04730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
H0232_RS04740	COG3022	response to hydroperoxide
H0232_RS04745	COG1473	amidohydrolase
H0232_RS04750	COG2807	transmembrane transport
H0232_RS04755	COG2807	transmembrane transport
H0232_RS04770	COG2181	nitrate reductase activity
H0232_RS04770	COG0247	lactate metabolic process
H0232_RS04775	COG0635	Involved in the biosynthesis of porphyrin-containing compound
H0232_RS04785	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
H0232_RS04790	COG0113	porphobilinogen synthase activity
H0232_RS04795	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
H0232_RS04810	COG2855	membrane
H0232_RS04815	COG0583	DNA-binding transcription factor activity
H0232_RS04820	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
H0232_RS04840	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0232_RS04845	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0232_RS04885	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
H0232_RS04885	COG1333	cytochrome c biogenesis protein
H0232_RS04910	COG0683	leucine binding
H0232_RS04935	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
H0232_RS04940	COG2204	response regulator
H0232_RS04955	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
H0232_RS04970	COG0481	GTPase activity
H0232_RS04995	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
H0232_RS05005	COG0439	Biotin carboxylase
H0232_RS05010	COG0772	Belongs to the SEDS family
H0232_RS05015	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
H0232_RS05035	COG0352	thiamine-phosphate diphosphorylase activity
H0232_RS05040	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
H0232_RS05045	COG2022	thiamine diphosphate biosynthetic process
H0232_RS05060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
H0232_RS05080	COG1193	negative regulation of DNA recombination
H0232_RS05090	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
H0232_RS05110	COG0516	GMP reductase activity
H0232_RS05110	COG0517	IMP dehydrogenase activity
H0232_RS05115	COG0154	amidase activity
H0232_RS05125	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
H0232_RS05130	COG1058	Belongs to the CinA family
H0232_RS05130	COG1546	Belongs to the CinA family
H0232_RS05135	COG0456	acetyltransferase
H0232_RS05140	COG0778	Nitroreductase
H0232_RS05145	COG0778	Nitroreductase
H0232_RS05155	COG0750	zinc metalloprotease
H0232_RS05160	COG2990	Protein conserved in bacteria
H0232_RS05165	COG0360	Binds together with S18 to 16S ribosomal RNA
H0232_RS05170	COG0629	single-stranded DNA binding
H0232_RS05175	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
H0232_RS05180	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
H0232_RS05190	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
H0232_RS05195	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
H0232_RS05240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
H0232_RS05250	COG0739	heme binding
H0232_RS05255	COG0285	dihydrofolate synthase activity
H0232_RS05275	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H0232_RS05280	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
H0232_RS05285	COG1862	Preprotein translocase
H0232_RS05290	COG0815	Transfers the fatty acyl group on membrane lipoproteins
H0232_RS05295	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
H0232_RS05300	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
H0232_RS05320	COG0210	DNA helicase
H0232_RS05340	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
H0232_RS05350	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
H0232_RS05355	COG0542	response to heat
H0232_RS05360	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
H0232_RS05370	COG2095	MarC family integral membrane protein
H0232_RS05375	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
H0232_RS05380	COG2833	Protein of unknown function (DUF455)
H0232_RS05385	COG1183	phosphatidylcholine synthase activity
H0232_RS05395	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
H0232_RS05400	COG2264	protein methyltransferase activity
H0232_RS05405	COG0745	RESPONSE REGULATOR receiver
H0232_RS05415	COG1086	Polysaccharide biosynthesis protein
H0232_RS05420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H0232_RS05425	COG0110	maltose O-acetyltransferase activity
H0232_RS05430	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
H0232_RS05435	COG0438	transferase activity, transferring glycosyl groups
H0232_RS05445	COG0438	transferase activity, transferring glycosyl groups
H0232_RS05450	COG1215	transferase activity, transferring glycosyl groups
H0232_RS05455	COG0438	transferase activity, transferring glycosyl groups
H0232_RS05460	COG1132	(ABC) transporter
H0232_RS05465	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0232_RS05475	COG0859	PFAM glycosyl transferase family 9
H0232_RS05480	COG1560	Kdo2-lipid A biosynthetic process
H0232_RS05490	COG1442	glycosyl transferase family 8
H0232_RS05490	COG1216	Glycosyl transferase, family 2
H0232_RS05500	COG1442	glycosyl transferase family 8
H0232_RS05500	COG1216	Glycosyl transferase, family 2
H0232_RS05510	COG2089	acid synthase
H0232_RS05525	COG0110	maltose O-acetyltransferase activity
H0232_RS05530	COG1216	Glycosyl transferase, family 2
H0232_RS05560	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H0232_RS05575	COG2217	Heavy metal translocating P-type atpase
H0232_RS05580	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
H0232_RS05585	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
H0232_RS05595	COG2217	Heavy metal translocating P-type atpase
H0232_RS05615	COG3610	response to peptide
H0232_RS05625	COG0039	L-malate dehydrogenase activity
H0232_RS05630	COG0586	Pfam SNARE associated Golgi protein
H0232_RS05645	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
H0232_RS05650	COG0217	transcriptional regulatory protein
H0232_RS05665	COG0018	arginyl-trna synthetase
H0232_RS05670	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
H0232_RS05675	COG0194	GDP metabolic process
H0232_RS05685	COG1684	flagellar biosynthetic protein fliR
H0232_RS05695	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
H0232_RS05700	COG0052	Belongs to the universal ribosomal protein uS2 family
H0232_RS05705	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
H0232_RS05715	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
H0232_RS05720	COG0723	plastoquinol--plastocyanin reductase activity
H0232_RS05725	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
H0232_RS05730	COG0445	tRNA wobble uridine modification
H0232_RS05750	COG1301	dicarboxylic acid transport
H0232_RS05765	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
H0232_RS05800	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
H0232_RS05815	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
H0232_RS05820	COG0552	protein localization to endoplasmic reticulum
H0232_RS05850	COG1295	ribonuclease BN
H0232_RS05855	COG0277	FAD linked oxidase domain protein
H0232_RS05865	COG0739	heme binding
H0232_RS05890	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
H0232_RS05900	COG0642	Histidine kinase
H0232_RS05905	COG0745	RESPONSE REGULATOR receiver
H0232_RS05910	COG2703	oxygen carrier activity
H0232_RS05925	COG0642	Histidine kinase
H0232_RS05930	COG0745	RESPONSE REGULATOR receiver
H0232_RS05935	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
H0232_RS05940	COG0484	heat shock protein binding
H0232_RS05945	COG0789	Transcriptional regulator
H0232_RS05950	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
H0232_RS05950	COG0475	glutathione-regulated potassium exporter activity
H0232_RS05965	COG0751	glycine-tRNA ligase activity
H0232_RS05970	COG0739	heme binding
H0232_RS05980	COG0248	Ppx GppA phosphatase
H0232_RS05985	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
H0232_RS05990	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
H0232_RS06000	COG2814	Major facilitator Superfamily
H0232_RS06015	COG0731	radical SAM domain protein
H0232_RS06070	COG1942	4-Oxalocrotonate Tautomerase
H0232_RS06085	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
H0232_RS06090	COG4773	Receptor
H0232_RS06095	COG0484	heat shock protein binding
H0232_RS06100	COG0745	RESPONSE REGULATOR receiver
H0232_RS06105	COG0642	Histidine kinase
H0232_RS06110	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
H0232_RS06115	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
H0232_RS06120	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
H0232_RS06125	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
H0232_RS06130	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H0232_RS06135	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
H0232_RS06135	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
H0232_RS06150	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
H0232_RS06155	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
H0232_RS06160	COG1758	RNA polymerase activity
H0232_RS06165	COG0528	UMP kinase activity
H0232_RS06180	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
H0232_RS06195	COG0564	pseudouridine synthase activity
H0232_RS06200	COG0772	Belongs to the SEDS family
H0232_RS06215	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
H0232_RS06220	COG0569	domain protein
H0232_RS06225	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
H0232_RS06230	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
H0232_RS06235	COG0280	phosphate acetyltransferase
H0232_RS06235	COG0281	malic enzyme
H0232_RS06240	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
H0232_RS06250	COG0439	Biotin carboxylase
H0232_RS06255	COG0511	ligase activity, forming carbon-carbon bonds
H0232_RS06260	COG0717	Belongs to the dCTP deaminase family
H0232_RS06265	COG1086	Polysaccharide biosynthesis protein
H0232_RS06270	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
H0232_RS06275	COG4310	Domain of unknown function (DUF2172)
H0232_RS06305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
H0232_RS06345	COG1083	cytidylyl-transferase
H0232_RS06365	COG3980	spore coat polysaccharide biosynthesis protein
H0232_RS06375	COG0107	imidazoleglycerol-phosphate synthase activity
H0232_RS06380	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
H0232_RS06390	COG2089	acid synthase
H0232_RS06435	COG2165	general secretion pathway protein
H0232_RS06440	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
H0232_RS06450	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
H0232_RS06455	COG0575	Belongs to the CDS family
H0232_RS06465	COG1293	RNA-binding protein homologous to eukaryotic snRNP
H0232_RS06470	COG0746	molybdenum cofactor guanylyltransferase activity
H0232_RS06475	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
H0232_RS06480	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H0232_RS06485	COG4605	iron ion homeostasis
H0232_RS06490	COG4604	ABC transporter, ATP-binding protein
H0232_RS06495	COG4607	ABC-type enterochelin transport system periplasmic component
H0232_RS06520	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
H0232_RS06525	COG3005	denitrification pathway
H0232_RS06530	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
H0232_RS06555	COG0628	permease
H0232_RS06560	COG0114	fumarate hydratase activity
H0232_RS06565	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
H0232_RS06575	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
H0232_RS06585	COG2252	PERMEase
H0232_RS06595	COG2853	Lipoprotein
H0232_RS06610	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
H0232_RS06615	COG2814	Major facilitator Superfamily
H0232_RS06630	COG1921	L-seryl-tRNASec selenium transferase activity
H0232_RS06635	COG3276	selenocysteine insertion sequence binding
H0232_RS06650	COG0716	FMN binding
H0232_RS06665	COG0753	catalase activity
H0232_RS06675	COG2964	Protein conserved in bacteria
H0232_RS06680	COG0251	oxidation-reduction process
H0232_RS06685	COG3069	C4-dicarboxylate transmembrane transporter activity
H0232_RS06705	COG1918	ferrous iron import across plasma membrane
H0232_RS06710	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
H0232_RS06715	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
H0232_RS06720	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
H0232_RS06725	COG0149	triose-phosphate isomerase activity
H0232_RS06730	COG0126	phosphoglycerate kinase activity
H0232_RS06735	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
H0232_RS06760	COG1580	Controls the rotational direction of flagella during chemotaxis
H0232_RS06765	COG0736	holo-[acyl-carrier-protein] synthase activity
H0232_RS06775	COG2124	cytochrome p450
H0232_RS06810	COG0529	Catalyzes the synthesis of activated sulfate
H0232_RS06830	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
H0232_RS06850	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0232_RS06855	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0232_RS06880	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
H0232_RS06895	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
H0232_RS06905	COG1442	glycosyl transferase family 8
H0232_RS06915	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
H0232_RS06920	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
H0232_RS06925	COG1088	dTDP-glucose 4,6-dehydratase activity
H0232_RS06930	COG1442	glycosyl transferase family 8
H0232_RS06930	COG1216	Glycosyl transferase, family 2
H0232_RS06935	COG1215	transferase activity, transferring glycosyl groups
H0232_RS06945	COG0517	IMP dehydrogenase activity
H0232_RS06945	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
H0232_RS06990	COG0037	tRNA processing
H0232_RS06995	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
H0232_RS07000	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
H0232_RS07010	COG0585	pseudouridine synthase activity
H0232_RS07015	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
H0232_RS07040	COG3951	Flagellar rod assembly protein muramidase FlgJ
H0232_RS07065	COG0730	response to heat
H0232_RS07070	COG1459	type II secretion system
H0232_RS07115	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
H0232_RS07120	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
H0232_RS07125	COG0210	DNA helicase
H0232_RS07130	COG2887	Belongs to the helicase family. UvrD subfamily
H0232_RS07175	COG0745	RESPONSE REGULATOR receiver
H0232_RS07190	COG0505	Belongs to the CarA family
H0232_RS07210	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
H0232_RS07225	COG0425	Belongs to the sulfur carrier protein TusA family
H0232_RS07230	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
H0232_RS07260	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
H0232_RS07270	COG0437	4 iron, 4 sulfur cluster binding
H0232_RS07305	COG0314	molybdopterin synthase activity
H0232_RS07310	COG0303	'Molybdopterin
H0232_RS07315	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
H0232_RS07325	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
H0232_RS07330	COG3069	C4-dicarboxylate transmembrane transporter activity
H0232_RS07335	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
H0232_RS07350	COG2992	FlgJ-related protein
H0232_RS07360	COG0783	Belongs to the Dps family
H0232_RS07365	COG0166	Belongs to the GPI family
H0232_RS07375	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
H0232_RS07380	COG3839	Belongs to the ABC transporter superfamily
H0232_RS07385	COG4662	Binding-protein-dependent transport system inner membrane component
H0232_RS07390	COG2998	abc-type tungstate transport system, permease component
H0232_RS07400	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
H0232_RS07415	COG2249	NAD(P)H dehydrogenase (quinone) activity
H0232_RS07420	COG1733	regulation of RNA biosynthetic process
H0232_RS07430	COG1064	alcohol dehydrogenase
H0232_RS07440	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
H0232_RS07465	COG0640	Transcriptional regulator
H0232_RS07490	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0232_RS07495	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
H0232_RS07505	COG0839	Belongs to the complex I subunit 6 family
H0232_RS07540	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0232_RS07545	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0232_RS07550	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
H0232_RS07565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
H0232_RS07570	COG0601	transmembrane transport
H0232_RS07590	COG4615	Cyclic peptide transporter
H0232_RS07610	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
H0232_RS07615	COG0257	Belongs to the bacterial ribosomal protein bL36 family
H0232_RS07625	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
H0232_RS07630	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
H0232_RS07635	COG0202	RNA polymerase activity
H0232_RS07640	COG0203	ribosomal protein L17
H0232_RS07645	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
H0232_RS07650	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
H0232_RS07655	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
H0232_RS07655	COG0131	Imidazoleglycerol-phosphate dehydratase
H0232_RS07665	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
H0232_RS07680	COG0140	phosphoribosyl-ATP diphosphatase activity
H0232_RS07680	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
H0232_RS07685	COG2171	N-acyltransferase activity
H0232_RS07690	COG0489	protein tyrosine kinase activity
H0232_RS07695	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
H0232_RS07695	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
H0232_RS07700	COG0745	RESPONSE REGULATOR receiver
H0232_RS07705	COG2046	Belongs to the sulfate adenylyltransferase family
H0232_RS07710	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
H0232_RS07715	COG0268	Binds directly to 16S ribosomal RNA
H0232_RS07720	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
H0232_RS07725	COG0748	coenzyme F420 binding
H0232_RS07730	COG4771	TonB-dependent receptor
H0232_RS07735	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
H0232_RS07740	COG1120	ATPase activity
H0232_RS07745	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
H0232_RS07755	COG0477	Major facilitator Superfamily
H0232_RS07760	COG1194	a g-specific adenine glycosylase
H0232_RS07800	COG1760	l-serine dehydratase
H0232_RS07805	COG0814	amino acid
H0232_RS07820	COG0811	peptide transport
H0232_RS07825	COG0848	biopolymer transport protein
H0232_RS07850	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
H0232_RS07860	COG0328	RNA-DNA hybrid ribonuclease activity
H0232_RS07870	COG0358	DNA primase activity
H0232_RS07885	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
H0232_RS07890	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
H0232_RS07905	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
H0232_RS07910	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
H0232_RS07915	COG1127	ABC transporter
H0232_RS07925	COG3218	ABC-type transport auxiliary lipoprotein component
H0232_RS07925	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
H0232_RS07935	COG0024	Methionine aminopeptidase
H0232_RS07940	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
H0232_RS07945	COG0791	NLP P60 protein
H0232_RS07950	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H0232_RS07955	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
H0232_RS07970	COG0672	)-iron permease
H0232_RS07995	COG1136	(ABC) transporter
H0232_RS08045	COG1793	dna ligase
H0232_RS08060	COG0148	phosphopyruvate hydratase activity
H0232_RS08065	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
H0232_RS08070	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
H0232_RS08075	COG1987	bacterial-type flagellum assembly
H0232_RS08090	COG1218	3'(2'),5'-bisphosphate nucleotidase
H0232_RS08095	COG0372	Belongs to the citrate synthase family
H0232_RS08110	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
H0232_RS08120	COG2936	dipeptidyl-peptidase activity
H0232_RS08130	COG0201	protein transport
H0232_RS08135	COG0200	Binds to the 23S rRNA
H0232_RS08140	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
H0232_RS08145	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
H0232_RS08150	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
H0232_RS08155	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
H0232_RS08160	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
H0232_RS08165	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
H0232_RS08170	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
H0232_RS08175	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
H0232_RS08180	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
H0232_RS08185	COG0255	Belongs to the universal ribosomal protein uL29 family
H0232_RS08190	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
H0232_RS08195	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
H0232_RS08200	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
H0232_RS08205	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
H0232_RS08215	COG0089	rRNA binding
H0232_RS08220	COG0088	Forms part of the polypeptide exit tunnel
H0232_RS08225	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
H0232_RS08230	COG0051	transcription antitermination factor activity, RNA binding
H0232_RS08235	COG1187	pseudouridine synthase activity
H0232_RS08240	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
H0232_RS08295	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
H0232_RS08300	COG0473	3-isopropylmalate dehydrogenase activity
H0232_RS08330	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
H0232_RS08340	COG1749	Flagellar hook protein flgE
H0232_RS08345	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group