locus-tag	class	description
CLAN_RS00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLAN_RS00010	COG0592	DNA-directed DNA polymerase activity
CLAN_RS00015	COG0187	DNA topoisomerase II activity
CLAN_RS00020	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CLAN_RS00040	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CLAN_RS00045	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
CLAN_RS00065	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
CLAN_RS00065	COG4797	methyltransferase
CLAN_RS00070	COG2181	nitrate reductase activity
CLAN_RS00070	COG0247	lactate metabolic process
CLAN_RS00075	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CLAN_RS00085	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLAN_RS00095	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLAN_RS00100	COG0113	porphobilinogen synthase activity
CLAN_RS00105	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLAN_RS00110	COG0357	Ribosomal RNA small subunit methyltransferase G
CLAN_RS00125	COG0501	Belongs to the peptidase M48B family
CLAN_RS00135	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CLAN_RS00140	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
CLAN_RS00145	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CLAN_RS00150	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CLAN_RS00155	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CLAN_RS00160	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CLAN_RS00170	COG0251	oxidation-reduction process
CLAN_RS00175	COG0237	dephospho-CoA kinase activity
CLAN_RS00190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLAN_RS00195	COG1104	cysteine desulfurase activity
CLAN_RS00215	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
CLAN_RS00220	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLAN_RS00230	COG0372	Belongs to the citrate synthase family
CLAN_RS00235	COG0475	glutathione-regulated potassium exporter activity
CLAN_RS00235	COG0569	domain protein
CLAN_RS00240	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLAN_RS00245	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLAN_RS00250	COG1007	ATP synthesis coupled electron transport
CLAN_RS00255	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLAN_RS00260	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CLAN_RS00265	COG0713	ATP synthesis coupled electron transport
CLAN_RS00270	COG0839	Belongs to the complex I subunit 6 family
CLAN_RS00275	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLAN_RS00280	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
CLAN_RS00285	COG1034	ATP synthesis coupled electron transport
CLAN_RS00300	COG0649	NAD binding
CLAN_RS00305	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLAN_RS00310	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
CLAN_RS00315	COG1966	Carbon starvation protein
CLAN_RS00320	COG2879	small protein
CLAN_RS00325	COG0840	transmembrane signaling receptor activity
CLAN_RS00375	COG2814	Major facilitator Superfamily
CLAN_RS00385	COG0573	inorganic phosphate transmembrane transporter activity
CLAN_RS00390	COG0581	inorganic phosphate transmembrane transporter activity
CLAN_RS00395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLAN_RS00405	COG5002	protein histidine kinase activity
CLAN_RS00410	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CLAN_RS00415	COG0148	phosphopyruvate hydratase activity
CLAN_RS00430	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CLAN_RS00465	COG0310	cobalt ion transport
CLAN_RS00475	COG1157	protein secretion by the type III secretion system
CLAN_RS00480	COG0302	gtp cyclohydrolase
CLAN_RS00485	COG0544	peptidyl-prolyl cis-trans isomerase activity
CLAN_RS00490	COG0740	serine-type endopeptidase activity
CLAN_RS00500	COG0242	peptide deformylase activity
CLAN_RS00505	COG0606	chelatase, subunit chli
CLAN_RS00510	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CLAN_RS00510	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CLAN_RS00515	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CLAN_RS00520	COG0861	Integral membrane protein TerC family
CLAN_RS00620	COG1442	glycosyl transferase family 8
CLAN_RS00620	COG1216	Glycosyl transferase, family 2
CLAN_RS00635	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLAN_RS00640	COG1442	glycosyl transferase family 8
CLAN_RS00640	COG1216	Glycosyl transferase, family 2
CLAN_RS00660	COG3468	outer membrane autotransporter barrel domain protein
CLAN_RS00665	COG0670	Belongs to the BI1 family
CLAN_RS00670	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CLAN_RS00675	COG0233	cytoplasmic translational termination
CLAN_RS00680	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CLAN_RS00690	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CLAN_RS00695	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CLAN_RS00695	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CLAN_RS00725	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLAN_RS00730	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CLAN_RS00785	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CLAN_RS00810	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLAN_RS00820	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLAN_RS00825	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLAN_RS00885	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CLAN_RS00890	COG2217	Heavy metal translocating P-type atpase
CLAN_RS00905	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
CLAN_RS00910	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLAN_RS00915	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
CLAN_RS00915	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
CLAN_RS00920	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
CLAN_RS00925	COG0859	PFAM glycosyl transferase family 9
CLAN_RS00935	COG0859	PFAM glycosyl transferase family 9
CLAN_RS00965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
CLAN_RS00970	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CLAN_RS00985	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CLAN_RS00985	COG0140	phosphoribosyl-ATP diphosphatase activity
CLAN_RS01010	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
CLAN_RS01015	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CLAN_RS01020	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
CLAN_RS01025	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLAN_RS01030	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CLAN_RS01035	COG1077	Cell shape determining protein MreB Mrl
CLAN_RS01045	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CLAN_RS01055	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CLAN_RS01075	COG0019	diaminopimelate decarboxylase activity
CLAN_RS01100	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CLAN_RS01110	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLAN_RS01125	COG0784	Response regulator, receiver
CLAN_RS01125	COG0835	chemotaxis
CLAN_RS01130	COG0784	Response regulator, receiver
CLAN_RS01130	COG2198	Histidine kinase
CLAN_RS01130	COG0643	Histidine kinase
CLAN_RS01135	COG0835	chemotaxis
CLAN_RS01150	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CLAN_RS01155	COG0193	aminoacyl-tRNA hydrolase activity
CLAN_RS01165	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLAN_RS01180	COG0540	Belongs to the ATCase OTCase family
CLAN_RS01195	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
CLAN_RS01200	COG0149	triose-phosphate isomerase activity
CLAN_RS01205	COG0126	phosphoglycerate kinase activity
CLAN_RS01210	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CLAN_RS01215	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CLAN_RS01220	COG0799	negative regulation of ribosome biogenesis
CLAN_RS01225	COG0018	arginyl-trna synthetase
CLAN_RS01230	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CLAN_RS01245	COG1684	flagellar biosynthetic protein fliR
CLAN_RS01255	COG0398	Pfam SNARE associated Golgi protein
CLAN_RS01260	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
CLAN_RS01275	COG1748	Saccharopine dehydrogenase
CLAN_RS01280	COG0254	rRNA binding
CLAN_RS01285	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CLAN_RS01290	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLAN_RS01305	COG0436	Aminotransferase
CLAN_RS01310	COG0460	homoserine dehydrogenase
CLAN_RS01315	COG0792	nuclease activity
CLAN_RS01320	COG3118	belongs to the thioredoxin family
CLAN_RS01325	COG0492	ferredoxin-NADP+ reductase activity
CLAN_RS01330	COG0683	leucine binding
CLAN_RS01385	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
CLAN_RS01390	COG0052	Belongs to the universal ribosomal protein uS2 family
CLAN_RS01400	COG1496	oxidoreductase activity
CLAN_RS01410	COG0445	tRNA wobble uridine modification
CLAN_RS01415	COG0723	plastoquinol--plastocyanin reductase activity
CLAN_RS01420	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
CLAN_RS01455	COG4106	trans-aconitate 2-methyltransferase activity
CLAN_RS01520	COG0318	PFAM AMP-dependent synthetase and ligase
CLAN_RS01525	COG1028	Short-chain dehydrogenase reductase Sdr
CLAN_RS01545	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CLAN_RS01560	COG0534	Mate efflux family protein
CLAN_RS01570	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CLAN_RS01575	COG0732	type I restriction modification DNA specificity domain
CLAN_RS01590	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
CLAN_RS01605	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
CLAN_RS01610	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
CLAN_RS01655	COG0482	sulfurtransferase activity
CLAN_RS01665	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLAN_RS01675	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
CLAN_RS01680	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CLAN_RS01685	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CLAN_RS01690	COG0450	alkyl hydroperoxide reductase
CLAN_RS01700	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CLAN_RS01705	COG1570	exodeoxyribonuclease VII activity
CLAN_RS01725	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CLAN_RS01735	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLAN_RS01745	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLAN_RS01750	COG0077	Prephenate dehydratase
CLAN_RS01750	COG1605	Chorismate mutase
CLAN_RS01760	COG0019	diaminopimelate decarboxylase activity
CLAN_RS01765	COG2244	polysaccharide biosynthetic process
CLAN_RS01770	COG0438	transferase activity, transferring glycosyl groups
CLAN_RS01780	COG0438	transferase activity, transferring glycosyl groups
CLAN_RS01790	COG0438	transferase activity, transferring glycosyl groups
CLAN_RS01795	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLAN_RS01825	COG2204	response regulator
CLAN_RS01830	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CLAN_RS01840	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
CLAN_RS01845	COG0731	radical SAM domain protein
CLAN_RS01860	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CLAN_RS01880	COG0556	nucleotide-excision repair
CLAN_RS01890	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CLAN_RS01895	COG0280	phosphate acetyltransferase
CLAN_RS01905	COG1295	ribonuclease BN
CLAN_RS01910	COG0277	FAD linked oxidase domain protein
CLAN_RS01920	COG0739	heme binding
CLAN_RS01920	COG0741	lytic transglycosylase activity
CLAN_RS01920	COG1196	nuclear chromosome segregation
CLAN_RS01925	COG2239	Acts as a magnesium transporter
CLAN_RS01965	COG3437	response regulator, receiver
CLAN_RS01970	COG3437	response regulator, receiver
CLAN_RS01970	COG2205	protein histidine kinase activity
CLAN_RS01970	COG3850	Histidine kinase
CLAN_RS01970	COG4999	Histidine kinase
CLAN_RS01980	COG0230	Belongs to the bacterial ribosomal protein bL34 family
CLAN_RS01985	COG0594	ribonuclease P activity
CLAN_RS01990	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CLAN_RS01995	COG0706	membrane insertase activity
CLAN_RS02005	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CLAN_RS02010	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CLAN_RS02015	COG0138	bifunctional purine biosynthesis protein purh
CLAN_RS02020	COG0840	transmembrane signaling receptor activity
CLAN_RS02025	COG1607	acyl-coa hydrolase
CLAN_RS02030	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CLAN_RS02035	COG0228	four-way junction DNA binding
CLAN_RS02045	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CLAN_RS02050	COG0336	Belongs to the RNA methyltransferase TrmD family
CLAN_RS02055	COG0335	large ribosomal subunit rRNA binding
CLAN_RS02065	COG2822	iron ion transport
CLAN_RS02070	COG2837	iron assimilation
CLAN_RS02075	COG0672	)-iron permease
CLAN_RS02085	COG0424	maF-like protein
CLAN_RS02095	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLAN_RS02100	COG2824	Alkylphosphonate utilization operon protein PhnA
CLAN_RS02105	COG1322	Protein conserved in bacteria
CLAN_RS02110	COG0579	oxidoreductase
CLAN_RS02120	COG0612	Peptidase, M16
CLAN_RS02125	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CLAN_RS02135	COG3210	domain, Protein
CLAN_RS02135	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
CLAN_RS02135	COG3064	Membrane
CLAN_RS02140	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CLAN_RS02145	COG0459	protein refolding
CLAN_RS02175	COG1028	Short-chain dehydrogenase reductase Sdr
CLAN_RS02195	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLAN_RS02200	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLAN_RS02210	COG0372	Belongs to the citrate synthase family
CLAN_RS02215	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
CLAN_RS02245	COG1555	photosystem II stabilization
CLAN_RS02275	COG3177	Filamentation induced by cAMP protein fic
CLAN_RS02280	COG1064	alcohol dehydrogenase
CLAN_RS02285	COG2249	NAD(P)H dehydrogenase (quinone) activity
CLAN_RS02300	COG0358	DNA primase activity
CLAN_RS02315	COG0571	ribonuclease III activity
CLAN_RS02320	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CLAN_RS02340	COG4773	Receptor
CLAN_RS02345	COG1706	bacterial-type flagellum-dependent cell motility
CLAN_RS02350	COG3951	Flagellar rod assembly protein muramidase FlgJ
CLAN_RS02375	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CLAN_RS02385	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
CLAN_RS02395	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CLAN_RS02400	COG1160	GTP binding
CLAN_RS02420	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CLAN_RS02430	COG2255	four-way junction helicase activity
CLAN_RS02435	COG0628	permease
CLAN_RS02440	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
CLAN_RS02445	COG1127	ABC transporter
CLAN_RS02485	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLAN_RS02500	COG0217	transcriptional regulatory protein
CLAN_RS02505	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CLAN_RS02535	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLAN_RS02540	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CLAN_RS02555	COG0250	Participates in transcription elongation, termination and antitermination
CLAN_RS02560	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CLAN_RS02565	COG0081	regulation of translation
CLAN_RS02570	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
CLAN_RS02580	COG0085	RNA polymerase activity
CLAN_RS02585	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CLAN_RS02595	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
CLAN_RS02600	COG0049	tRNA binding
CLAN_RS02605	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLAN_RS02615	COG1918	ferrous iron import across plasma membrane
CLAN_RS02620	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
CLAN_RS02635	COG1230	cation diffusion facilitator family transporter
CLAN_RS02690	COG3064	Membrane
CLAN_RS02690	COG0437	4 iron, 4 sulfur cluster binding
CLAN_RS02720	COG0275	rRNA processing
CLAN_RS02730	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLAN_RS02735	COG0849	cell division
CLAN_RS02750	COG0786	glutamate:sodium symporter activity
CLAN_RS02760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLAN_RS02770	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
CLAN_RS02775	COG0653	protein targeting
CLAN_RS02780	COG4591	ABC-type transport system involved in lipoprotein release permease component
CLAN_RS02810	COG0815	Transfers the fatty acyl group on membrane lipoproteins
CLAN_RS02815	COG1862	Preprotein translocase
CLAN_RS02820	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLAN_RS02825	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLAN_RS02835	COG0495	leucyl-tRNA aminoacylation
CLAN_RS02850	COG0285	dihydrofolate synthase activity
CLAN_RS02855	COG0739	heme binding
CLAN_RS02865	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CLAN_RS02890	COG1832	CoA-binding protein
CLAN_RS02895	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CLAN_RS02910	COG0519	Catalyzes the synthesis of GMP from XMP
CLAN_RS02920	COG1968	undecaprenyl-diphosphatase activity
CLAN_RS02925	COG0352	thiamine-phosphate diphosphorylase activity
CLAN_RS02940	COG0765	amino acid transport
CLAN_RS02945	COG4786	Flagellar basal body rod
CLAN_RS02965	COG1696	Membrane protein involved in D-alanine export
CLAN_RS03005	COG0488	(ABC) transporter
CLAN_RS03010	COG0733	neurotransmitter:sodium symporter activity
CLAN_RS03015	COG0501	Belongs to the peptidase M48B family
CLAN_RS03020	COG2890	protein-(glutamine-N5) methyltransferase activity
CLAN_RS03030	COG0824	Thioesterase
CLAN_RS03070	COG1185	polyribonucleotide nucleotidyltransferase activity
CLAN_RS03080	COG0537	adenosine 5'-monophosphoramidase activity
CLAN_RS03085	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
CLAN_RS03095	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CLAN_RS03100	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLAN_RS03105	COG1185	polyribonucleotide nucleotidyltransferase activity
CLAN_RS03105	COG0539	negative regulation of cytoplasmic translation
CLAN_RS03115	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
CLAN_RS03120	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
CLAN_RS03125	COG1999	signal sequence binding
CLAN_RS03130	COG0772	Belongs to the SEDS family
CLAN_RS03135	COG0564	pseudouridine synthase activity
CLAN_RS03145	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CLAN_RS03150	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLAN_RS03165	COG0528	UMP kinase activity
CLAN_RS03170	COG1758	RNA polymerase activity
CLAN_RS03180	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CLAN_RS03190	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLAN_RS03195	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLAN_RS03195	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
CLAN_RS03210	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CLAN_RS03215	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
CLAN_RS03225	COG0642	Histidine kinase
CLAN_RS03235	COG0166	Belongs to the GPI family
CLAN_RS03240	COG0783	Belongs to the Dps family
CLAN_RS03245	COG2353	YceI-like domain
CLAN_RS03265	COG0585	pseudouridine synthase activity
CLAN_RS03270	COG0840	transmembrane signaling receptor activity
CLAN_RS03275	COG1858	cytochrome C peroxidase
CLAN_RS03295	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CLAN_RS03315	COG1739	Uncharacterized protein family UPF0029
CLAN_RS03320	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CLAN_RS03330	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLAN_RS03335	COG2201	protein-glutamate methylesterase activity
CLAN_RS03345	COG0632	four-way junction helicase activity
CLAN_RS03350	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLAN_RS03365	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLAN_RS03390	COG2252	PERMEase
CLAN_RS03395	COG1060	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate
CLAN_RS03405	COG1677	Flagellar hook-basal body complex protein FliE
CLAN_RS03420	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
CLAN_RS03425	COG0542	response to heat
CLAN_RS03430	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CLAN_RS03440	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CLAN_RS03445	COG0436	Aminotransferase
CLAN_RS03450	COG1045	serine acetyltransferase
CLAN_RS03455	COG1166	arginine decarboxylase activity
CLAN_RS03460	COG0124	histidyl-tRNA synthetase
CLAN_RS03465	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CLAN_RS03470	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CLAN_RS03485	COG0303	'Molybdopterin
CLAN_RS03490	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
CLAN_RS03495	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CLAN_RS03500	COG0501	Belongs to the peptidase M48B family
CLAN_RS03505	COG0688	phosphatidylethanolamine metabolic process
CLAN_RS03510	COG1408	metallophosphoesterase
CLAN_RS03515	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
CLAN_RS03540	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLAN_RS03560	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CLAN_RS03565	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLAN_RS03580	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLAN_RS03585	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
CLAN_RS03590	COG0642	Histidine kinase
CLAN_RS03595	COG0745	RESPONSE REGULATOR receiver
CLAN_RS03610	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CLAN_RS03615	COG0629	single-stranded DNA binding
CLAN_RS03620	COG0360	Binds together with S18 to 16S ribosomal RNA
CLAN_RS03630	COG0557	exoribonuclease II activity
CLAN_RS03640	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CLAN_RS03645	COG2861	carbohydrate metabolic process
CLAN_RS03650	COG0758	DNA mediated transformation
CLAN_RS03655	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CLAN_RS03660	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
CLAN_RS03660	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLAN_RS03665	COG0788	formyltetrahydrofolate deformylase activity
CLAN_RS03670	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CLAN_RS03685	COG0751	glycine-tRNA ligase activity
CLAN_RS03700	COG0739	heme binding
CLAN_RS03710	COG0745	RESPONSE REGULATOR receiver
CLAN_RS03715	COG0642	Histidine kinase
CLAN_RS03720	COG1556	Lactate utilization protein
CLAN_RS03725	COG1139	Iron-sulfur cluster binding protein
CLAN_RS03730	COG0247	lactate metabolic process
CLAN_RS03735	COG1620	l-lactate permease
CLAN_RS03740	COG0326	Molecular chaperone. Has ATPase activity
CLAN_RS03770	COG3706	GGDEF domain
CLAN_RS03775	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
CLAN_RS03780	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CLAN_RS03785	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CLAN_RS03790	COG1663	tetraacyldisaccharide 4'-kinase activity
CLAN_RS03795	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLAN_RS03800	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLAN_RS03810	COG2050	protein possibly involved in aromatic compounds catabolism
CLAN_RS03810	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
CLAN_RS03815	COG0500	methyltransferase
CLAN_RS03825	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLAN_RS03865	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CLAN_RS03870	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLAN_RS03875	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CLAN_RS03880	COG0753	catalase activity
CLAN_RS03895	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLAN_RS03900	COG1959	2 iron, 2 sulfur cluster binding
CLAN_RS03915	COG0137	argininosuccinate synthase activity
CLAN_RS03920	COG0582	viral genome integration into host DNA
CLAN_RS03925	COG0772	Belongs to the SEDS family
CLAN_RS03930	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLAN_RS03935	COG0776	regulation of translation
CLAN_RS03940	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CLAN_RS03950	COG1137	ATPase activity
CLAN_RS03955	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CLAN_RS03960	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CLAN_RS03970	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLAN_RS03980	COG0521	Mo-molybdopterin cofactor biosynthetic process
CLAN_RS03985	COG0343	queuine tRNA-ribosyltransferase activity
CLAN_RS04000	COG1196	nuclear chromosome segregation
CLAN_RS04030	COG4221	oxidoreductase activity
CLAN_RS04035	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
CLAN_RS04055	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CLAN_RS04065	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
CLAN_RS04075	COG0440	acetolactate synthase activity
CLAN_RS04080	COG0028	Belongs to the TPP enzyme family
CLAN_RS04105	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
CLAN_RS04110	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CLAN_RS04130	COG0210	DNA helicase
CLAN_RS04135	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CLAN_RS04150	COG0359	binds to the 23S rRNA
CLAN_RS04155	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
CLAN_RS04165	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CLAN_RS04170	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLAN_RS04170	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLAN_RS04180	COG0564	pseudouridine synthase activity
CLAN_RS04185	COG1519	Transferase
CLAN_RS04185	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CLAN_RS04195	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CLAN_RS04200	COG0752	glycyl-tRNA synthetase alpha subunit
CLAN_RS04210	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CLAN_RS04215	COG0826	peptidase U32
CLAN_RS04230	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CLAN_RS04235	COG0174	glutamine synthetase
CLAN_RS04240	COG0736	holo-[acyl-carrier-protein] synthase activity
CLAN_RS04245	COG1580	Controls the rotational direction of flagella during chemotaxis
CLAN_RS04250	COG0179	Fumarylacetoacetate (FAA) hydrolase
CLAN_RS04255	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CLAN_RS04260	COG2860	membrane
CLAN_RS04265	COG0716	FMN binding
CLAN_RS04275	COG3962	Belongs to the TPP enzyme family
CLAN_RS04280	COG0674	pyruvate-flavodoxin oxidoreductase activity
CLAN_RS04280	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
CLAN_RS04290	COG0039	L-malate dehydrogenase activity
CLAN_RS04305	COG2833	Protein of unknown function (DUF455)
CLAN_RS04320	COG2176	DNA-directed DNA polymerase activity
CLAN_RS04325	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CLAN_RS04330	COG0750	zinc metalloprotease
CLAN_RS04335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CLAN_RS04340	COG0542	response to heat
CLAN_RS04345	COG0793	Belongs to the peptidase S41A family
CLAN_RS04350	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
CLAN_RS04355	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CLAN_RS04360	COG0047	phosphoribosylformylglycinamidine synthase activity
CLAN_RS04370	COG0204	Acyl-transferase
CLAN_RS04375	COG0586	Pfam SNARE associated Golgi protein
CLAN_RS04385	COG1338	Plays a role in the flagellum-specific transport system
CLAN_RS04390	COG2226	methyltransferase
CLAN_RS04405	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CLAN_RS04410	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CLAN_RS04425	COG0527	aspartate kinase activity
CLAN_RS04430	COG0494	nUDIX hydrolase
CLAN_RS04435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLAN_RS04440	COG0443	Heat shock 70 kDa protein
CLAN_RS04445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CLAN_RS04450	COG1420	regulation of RNA biosynthetic process
CLAN_RS04465	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLAN_RS04475	COG0728	peptidoglycan biosynthetic process
CLAN_RS04480	COG0215	cysteine-tRNA ligase activity
CLAN_RS04485	COG1132	(ABC) transporter
CLAN_RS04500	COG0167	dihydroorotate dehydrogenase activity
CLAN_RS04505	COG0612	Peptidase, M16
CLAN_RS04510	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLAN_RS04515	COG1028	Short-chain dehydrogenase reductase Sdr
CLAN_RS04525	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLAN_RS04530	COG0765	amino acid transport
CLAN_RS04535	COG1126	abc transporter atp-binding protein
CLAN_RS04540	COG2962	Rard protein
CLAN_RS04550	COG1472	Belongs to the glycosyl hydrolase 3 family
CLAN_RS04555	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CLAN_RS04560	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
CLAN_RS04575	COG0356	it plays a direct role in the translocation of protons across the membrane
CLAN_RS04580	COG0730	response to heat
CLAN_RS04585	COG3263	regulation of cellular component size
CLAN_RS04590	COG0475	glutathione-regulated potassium exporter activity
CLAN_RS04590	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
CLAN_RS04595	COG0789	Transcriptional regulator
CLAN_RS04600	COG0484	heat shock protein binding
CLAN_RS04610	COG0745	RESPONSE REGULATOR receiver
CLAN_RS04615	COG0642	Histidine kinase
CLAN_RS04625	COG1538	Outer membrane efflux protein
CLAN_RS04630	COG1136	(ABC) transporter
CLAN_RS04630	COG0577	efflux transmembrane transporter activity
CLAN_RS04635	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLAN_RS04640	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CLAN_RS04645	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CLAN_RS04655	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CLAN_RS04670	COG0101	tRNA pseudouridine synthase activity
CLAN_RS04690	COG3043	anaerobic respiration
CLAN_RS04695	COG0348	domain, Protein
CLAN_RS04700	COG0437	4 iron, 4 sulfur cluster binding
CLAN_RS04705	COG0243	molybdopterin cofactor binding
CLAN_RS04710	COG0012	GTP binding
CLAN_RS04715	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
CLAN_RS04725	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLAN_RS04735	COG0698	ribose 5-phosphate isomerase
CLAN_RS04740	COG0681	Belongs to the peptidase S26 family
CLAN_RS04745	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CLAN_RS04755	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CLAN_RS04775	COG2257	FlhB HrpN YscU SpaS Family
CLAN_RS04780	COG0428	transporter
CLAN_RS04795	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLAN_RS04795	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLAN_RS04805	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
CLAN_RS04815	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLAN_RS04825	COG1193	negative regulation of DNA recombination
CLAN_RS04845	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLAN_RS04850	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CLAN_RS04870	COG4771	TonB-dependent receptor
CLAN_RS04890	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CLAN_RS04895	COG3022	response to hydroperoxide
CLAN_RS04905	COG0134	indole-3-glycerol-phosphate synthase activity
CLAN_RS04915	COG0727	PFAM Uncharacterised protein family (UPF0153)
CLAN_RS04920	COG2813	Specifically methylates the guanine in position
CLAN_RS04930	COG0492	ferredoxin-NADP+ reductase activity
CLAN_RS04950	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLAN_RS04955	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CLAN_RS04970	COG2022	thiamine diphosphate biosynthetic process
CLAN_RS04980	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLAN_RS05020	COG1418	mRNA catabolic process
CLAN_RS05025	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CLAN_RS05030	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLAN_RS05035	COG0552	protein localization to endoplasmic reticulum
CLAN_RS05040	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CLAN_RS05070	COG1854	S-ribosylhomocysteine lyase activity
CLAN_RS05075	COG0716	FMN binding
CLAN_RS05100	COG0191	fructose-bisphosphate aldolase activity
CLAN_RS05105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
CLAN_RS05120	COG0305	Participates in initiation and elongation during chromosome replication
CLAN_RS05125	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CLAN_RS05135	COG1049	propionate catabolic process, 2-methylcitrate cycle
CLAN_RS05145	COG1333	cytochrome c biogenesis protein
CLAN_RS05145	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CLAN_RS05150	COG0181	hydroxymethylbilane synthase activity
CLAN_RS05160	COG0442	prolyl-tRNA aminoacylation
CLAN_RS05165	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CLAN_RS05185	COG1674	ftsk spoiiie
CLAN_RS05185	COG1196	nuclear chromosome segregation
CLAN_RS05190	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLAN_RS05200	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
CLAN_RS05205	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
CLAN_RS05225	COG0439	Biotin carboxylase
CLAN_RS05230	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLAN_RS05235	COG1086	Polysaccharide biosynthesis protein
CLAN_RS05240	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLAN_RS05245	COG0004	ammonium transporteR
CLAN_RS05270	COG1846	Transcriptional regulator
CLAN_RS05270	COG0456	acetyltransferase
CLAN_RS05275	COG0218	Necessary for normal cell division and for the maintenance of normal septation
CLAN_RS05290	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
CLAN_RS05295	COG0131	Imidazoleglycerol-phosphate dehydratase
CLAN_RS05300	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
CLAN_RS05310	COG0084	hydrolase, TatD family'
CLAN_RS05315	COG2199	diguanylate cyclase activity
CLAN_RS05320	COG0497	DNA recombination
CLAN_RS05330	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CLAN_RS05335	COG0563	adenylate kinase activity
CLAN_RS05340	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CLAN_RS05345	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CLAN_RS05355	COG1053	succinate dehydrogenase
CLAN_RS05360	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CLAN_RS05375	COG1902	pentaerythritol trinitrate reductase activity
CLAN_RS05400	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
CLAN_RS05405	COG0516	GMP reductase activity
CLAN_RS05405	COG0517	IMP dehydrogenase activity
CLAN_RS05410	COG0154	amidase activity
CLAN_RS05415	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
CLAN_RS05420	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CLAN_RS05425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
CLAN_RS05430	COG0805	protein transport
CLAN_RS05435	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CLAN_RS05450	COG0309	Hydrogenase expression formation protein (HypE)
CLAN_RS05470	COG0298	carbon dioxide binding
CLAN_RS05475	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CLAN_RS05480	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
CLAN_RS05490	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
CLAN_RS05495	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
CLAN_RS05500	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
CLAN_RS05505	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
CLAN_RS05515	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CLAN_RS05520	COG0114	fumarate hydratase activity
CLAN_RS05535	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CLAN_RS05540	COG2011	ABC-type metal ion transport system permease component
CLAN_RS05550	COG0352	thiamine-phosphate diphosphorylase activity
CLAN_RS05550	COG0351	phosphomethylpyrimidine kinase
CLAN_RS05560	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CLAN_RS05570	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CLAN_RS05580	COG0840	transmembrane signaling receptor activity
CLAN_RS05590	COG1058	Belongs to the CinA family
CLAN_RS05590	COG1546	Belongs to the CinA family
CLAN_RS05595	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
CLAN_RS05610	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLAN_RS05630	COG0463	Glycosyl transferase, family 2
CLAN_RS05640	COG0733	neurotransmitter:sodium symporter activity
CLAN_RS05650	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CLAN_RS05655	COG0165	Argininosuccinate lyase
CLAN_RS05725	COG1301	dicarboxylic acid transport
CLAN_RS05750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLAN_RS05765	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLAN_RS05770	COG1183	phosphatidylcholine synthase activity
CLAN_RS05780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLAN_RS05785	COG2264	protein methyltransferase activity
CLAN_RS05790	COG0745	RESPONSE REGULATOR receiver
CLAN_RS05795	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CLAN_RS05800	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CLAN_RS05810	COG1086	Polysaccharide biosynthesis protein
CLAN_RS05815	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLAN_RS05845	COG3550	peptidyl-serine autophosphorylation
CLAN_RS05865	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLAN_RS05875	COG1028	Short-chain dehydrogenase reductase Sdr
CLAN_RS05880	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLAN_RS05885	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLAN_RS05890	COG0825	malonyl-CoA metabolic process
CLAN_RS05920	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CLAN_RS05925	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CLAN_RS05930	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLAN_RS05935	COG0037	tRNA processing
CLAN_RS05960	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLAN_RS05970	COG0195	Participates in both transcription termination and antitermination
CLAN_RS05980	COG3421	Type III restriction
CLAN_RS05985	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CLAN_RS05995	COG1178	ABC-type Fe3 transport system permease component
CLAN_RS06000	COG1840	ABC-type Fe3 transport system, periplasmic component
CLAN_RS06005	COG0471	metal ion transport
CLAN_RS06015	COG4263	nitrous-oxide reductase activity
CLAN_RS06030	COG0437	4 iron, 4 sulfur cluster binding
CLAN_RS06045	COG0348	domain, Protein
CLAN_RS06050	COG3842	ATPase activity
CLAN_RS06070	COG0037	tRNA processing
CLAN_RS06075	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CLAN_RS06080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CLAN_RS06085	COG1047	Peptidyl-prolyl cis-trans
CLAN_RS06100	COG0823	Involved in the tonB-independent uptake of proteins
CLAN_RS06110	COG0848	biopolymer transport protein
CLAN_RS06115	COG0811	peptide transport
CLAN_RS06120	COG0355	proton-transporting ATP synthase activity, rotational mechanism
CLAN_RS06125	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CLAN_RS06130	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CLAN_RS06135	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CLAN_RS06140	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLAN_RS06155	COG1475	DNA binding
CLAN_RS06160	COG1192	Involved in chromosome partitioning
CLAN_RS06165	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CLAN_RS06165	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CLAN_RS06170	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CLAN_RS06180	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CLAN_RS06185	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CLAN_RS06190	COG0261	This protein binds to 23S rRNA in the presence of protein L20
CLAN_RS06205	COG1083	cytidylyl-transferase
CLAN_RS06215	COG0811	peptide transport
CLAN_RS06220	COG0848	biopolymer transport protein
CLAN_RS06230	COG2089	acid synthase
CLAN_RS06235	COG2089	acid synthase
CLAN_RS06240	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CLAN_RS06245	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CLAN_RS06255	COG1083	cytidylyl-transferase
CLAN_RS06260	COG1028	Short-chain dehydrogenase reductase Sdr
CLAN_RS06270	COG1776	CheC inhibitor of MCP methylation
CLAN_RS06270	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLAN_RS06275	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLAN_RS06280	COG1191	sigma factor activity
CLAN_RS06290	COG0455	bacterial-type flagellum organization
CLAN_RS06295	COG1419	protein localization to endoplasmic reticulum
CLAN_RS06300	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CLAN_RS06305	COG0006	proline dipeptidase activity
CLAN_RS06310	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CLAN_RS06315	COG0402	S-adenosylhomocysteine deaminase activity
CLAN_RS06320	COG0616	signal peptide processing
CLAN_RS06325	COG2258	MOSC domain
CLAN_RS06330	COG0754	glutathionylspermidine amidase activity
CLAN_RS06335	COG0163	prenyltransferase activity
CLAN_RS06345	COG0562	UDP-galactopyranose mutase
CLAN_RS06355	COG0438	transferase activity, transferring glycosyl groups
CLAN_RS06360	COG1216	Glycosyl transferase, family 2
CLAN_RS06360	COG1442	glycosyl transferase family 8
CLAN_RS06365	COG1216	Glycosyl transferase, family 2
CLAN_RS06415	COG1064	alcohol dehydrogenase
CLAN_RS06425	COG4773	Receptor
CLAN_RS06440	COG0284	orotidine-5'-phosphate decarboxylase activity
CLAN_RS06445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLAN_RS06450	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
CLAN_RS06470	COG0252	asparaginase activity
CLAN_RS06490	COG0668	transmembrane transport
CLAN_RS06500	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CLAN_RS06505	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CLAN_RS06510	COG1074	ATP-dependent DNA helicase activity
CLAN_RS06555	COG3278	Belongs to the heme-copper respiratory oxidase family
CLAN_RS06570	COG0505	Belongs to the CarA family
CLAN_RS06590	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
CLAN_RS06595	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
CLAN_RS06640	COG3842	ATPase activity
CLAN_RS06665	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLAN_RS06665	COG0512	Glutamine amidotransferase of anthranilate synthase
CLAN_RS06690	COG0135	phosphoribosylanthranilate isomerase activity
CLAN_RS06690	COG0134	indole-3-glycerol-phosphate synthase activity
CLAN_RS06695	COG0133	tryptophan synthase activity
CLAN_RS06710	COG1776	CheC inhibitor of MCP methylation
CLAN_RS06710	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLAN_RS06720	COG2171	N-acyltransferase activity
CLAN_RS06725	COG0488	(ABC) transporter
CLAN_RS06740	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CLAN_RS06745	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
CLAN_RS06750	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLAN_RS06760	COG1611	Belongs to the LOG family
CLAN_RS06765	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLAN_RS06765	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
CLAN_RS06770	COG0779	Required for maturation of 30S ribosomal subunits
CLAN_RS06780	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CLAN_RS06790	COG0083	homoserine kinase activity
CLAN_RS06800	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
CLAN_RS06810	COG0287	Prephenate dehydrogenase
CLAN_RS06815	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
CLAN_RS06825	COG0642	Histidine kinase
CLAN_RS06830	COG0745	RESPONSE REGULATOR receiver
CLAN_RS06840	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CLAN_RS06845	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLAN_RS06850	COG0416	fatty acid biosynthetic process
CLAN_RS06855	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CLAN_RS06865	COG0105	UTP biosynthetic process
CLAN_RS06875	COG1360	Flagellar Motor Protein
CLAN_RS06880	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CLAN_RS06895	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CLAN_RS06915	COG0602	queuosine metabolic process
CLAN_RS06920	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CLAN_RS06940	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CLAN_RS06960	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
CLAN_RS06965	COG0575	Belongs to the CDS family
CLAN_RS06980	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLAN_RS06985	COG1666	GTP binding
CLAN_RS06995	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLAN_RS07005	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
CLAN_RS07010	COG0281	malic enzyme
CLAN_RS07010	COG0280	phosphate acetyltransferase
CLAN_RS07025	COG1427	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CLAN_RS07030	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CLAN_RS07035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CLAN_RS07055	COG1086	Polysaccharide biosynthesis protein
CLAN_RS07060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CLAN_RS07065	COG1121	(ABC) transporter
CLAN_RS07085	COG0288	reversible hydration of carbon dioxide
CLAN_RS07090	COG0668	transmembrane transport
CLAN_RS07100	COG0708	Exodeoxyribonuclease III
CLAN_RS07105	COG2194	sulfuric ester hydrolase activity
CLAN_RS07115	COG1971	Probably functions as a manganese efflux pump
CLAN_RS07120	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CLAN_RS07125	COG0268	Binds directly to 16S ribosomal RNA
CLAN_RS07130	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLAN_RS07135	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CLAN_RS07145	COG1981	membrane
CLAN_RS07220	COG0556	nucleotide-excision repair
CLAN_RS07250	COG0248	Ppx GppA phosphatase
CLAN_RS07270	COG0473	3-isopropylmalate dehydrogenase activity
CLAN_RS07275	COG0066	3-isopropylmalate dehydratase activity
CLAN_RS07290	COG0693	protein deglycase activity
CLAN_RS07305	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CLAN_RS07305	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLAN_RS07310	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CLAN_RS07315	COG0129	dihydroxy-acid dehydratase activity
CLAN_RS07330	COG0110	maltose O-acetyltransferase activity
CLAN_RS07335	COG1749	Flagellar hook protein flgE
CLAN_RS07340	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
CLAN_RS07350	COG1217	gtp-binding protein TYPA
CLAN_RS07355	COG0778	Nitroreductase
CLAN_RS07365	COG2814	Major facilitator Superfamily
CLAN_RS07430	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLAN_RS07435	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLAN_RS07455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLAN_RS07460	COG1028	Short-chain dehydrogenase reductase Sdr
CLAN_RS07470	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLAN_RS07490	COG1749	Flagellar hook protein flgE
CLAN_RS07495	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CLAN_RS07500	COG2107	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)
CLAN_RS07525	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLAN_RS07540	COG0314	molybdopterin synthase activity
CLAN_RS07545	COG0628	permease
CLAN_RS07550	COG1027	Aspartate ammonia-lyase
CLAN_RS07555	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CLAN_RS07570	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CLAN_RS07575	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CLAN_RS07580	COG0481	GTPase activity
CLAN_RS07590	COG1942	4-Oxalocrotonate Tautomerase
CLAN_RS07605	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLAN_RS07610	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLAN_RS07615	COG0717	Belongs to the dCTP deaminase family
CLAN_RS07630	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLAN_RS07665	COG1253	flavin adenine dinucleotide binding
CLAN_RS07670	COG1538	Outer membrane efflux protein
CLAN_RS07680	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLAN_RS07690	COG0828	Belongs to the bacterial ribosomal protein bS21 family
CLAN_RS07705	COG2921	Belongs to the UPF0250 family
CLAN_RS07710	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CLAN_RS07725	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
CLAN_RS07730	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CLAN_RS07735	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLAN_RS07750	COG0203	ribosomal protein L17
CLAN_RS07755	COG0202	RNA polymerase activity
CLAN_RS07760	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLAN_RS07765	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CLAN_RS07770	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CLAN_RS07775	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CLAN_RS07780	COG1151	hydroxylamine reductase activity
CLAN_RS07795	COG0024	Methionine aminopeptidase
CLAN_RS07800	COG0201	protein transport
CLAN_RS07805	COG0200	Binds to the 23S rRNA
CLAN_RS07810	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CLAN_RS07815	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CLAN_RS07820	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CLAN_RS07825	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CLAN_RS07830	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
CLAN_RS07840	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CLAN_RS07845	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CLAN_RS07850	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CLAN_RS07860	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CLAN_RS07865	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CLAN_RS07870	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CLAN_RS07875	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CLAN_RS07880	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CLAN_RS07885	COG0089	rRNA binding
CLAN_RS07890	COG0088	Forms part of the polypeptide exit tunnel
CLAN_RS07895	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CLAN_RS07900	COG0051	transcription antitermination factor activity, RNA binding
CLAN_RS07940	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CLAN_RS07950	COG0587	DNA-directed DNA polymerase activity
CLAN_RS07955	COG0840	transmembrane signaling receptor activity
CLAN_RS08020	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLAN_RS08035	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
CLAN_RS08045	COG0745	RESPONSE REGULATOR receiver
CLAN_RS08050	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CLAN_RS08050	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CLAN_RS08055	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
CLAN_RS08060	COG2855	membrane
CLAN_RS08065	COG0512	Glutamine amidotransferase of anthranilate synthase
CLAN_RS08065	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLAN_RS08075	COG0489	protein tyrosine kinase activity
CLAN_RS08080	COG2346	COG2346, Truncated hemoglobins
CLAN_RS08090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
CLAN_RS08155	COG1187	pseudouridine synthase activity
CLAN_RS08160	COG0517	IMP dehydrogenase activity
CLAN_RS08160	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
CLAN_RS08170	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CLAN_RS08175	COG0107	imidazoleglycerol-phosphate synthase activity
CLAN_RS08185	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CLAN_RS08190	COG0564	pseudouridine synthase activity
CLAN_RS08195	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CLAN_RS08200	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLAN_RS08205	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group